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NCAN Gene

protein-coding   GIFtS: 63
GCID: GC19P019322

Neurocan

(Previous name: chondroitin sulfate proteoglycan 3)
(Previous symbol: CSPG3)
  Search for NCAN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
neurocan1 2     Chondroitin Sulfate Proteoglycan 3 (Neurocan)2
CSPG31 2 3 5     Neurocan Core Protein2
Chondroitin Sulfate Proteoglycan 31 3     NEUR3
Neurocan Proteoglycan1 2     

External Ids:    HGNC: 24651   Entrez Gene: 14632   Ensembl: ENSG000001302877   OMIM: 6008265   UniProtKB: O145943   

Export aliases for NCAN gene to outside databases

Previous GC identifers: GC19P019183 GC19P018887


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCAN Gene:
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and
migration.(supplied by OMIM, Jul 2002)

GeneCards Summary for NCAN Gene:
NCAN (neurocan) is a protein-coding gene. GO annotations related to this gene include hyaluronic acid binding and calcium ion binding. An important paralog of this gene is HAPLN3.

UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594
Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion
molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid

Gene Wiki entry for NCAN (Neurocan) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCAN gene promoter:
         Max1   SRF   NRSF form 1   POU3F2   NRSF form 2   c-Ets-1   Roaz   AREB6   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCAN promoter sequence
   Search Chromatin IP Primers for NCAN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCAN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p12

NCAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAN gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P019322:  view genomic region     (about GC identifiers)

Start:
19,322,782 bp from pter      End:
19,363,061 bp from pter
Size:
40,280 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594 (See protein sequence)
Recommended Name: Neurocan core protein precursor  
Size: 1321 amino acids; 143093 Da
Secondary accessions: Q9UPK6

Explore the universe of human proteins at neXtProt for NCAN: NX_O14594

Explore proteomics data for NCAN at MOPED

Post-translational modifications: 

  • O-glycosylated1
  • Glycosylation2 at Asn122, Asn340, Asn1026, Asn1223
  • Modification sites at PhosphoSitePlus

  • See NCAN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004377.2  
    ENSEMBL proteins: 
     ENSP00000252575   ENSP00000465599   ENSP00000442202  
    Reactome Protein details: O14594

    NCAN Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant NCAN Protein
    R&D Systems Recombinant & Natural Proteins for NCAN (Neurocan)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NCAN
    GenScript Custom Purified and Recombinant Proteins Services for NCAN
    Novus Biologicals NCAN Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NCAN

     
    Search eBioscience for Proteins for NCAN 

    NCAN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NCAN
    R&D Systems Antibodies for NCAN (Neurocan)
    OriGene Antibodies for NCAN
    OriGene Custom Antibody Services for NCAN
    Novus Biologicals NCAN Antibodies
    Search for Antibodies for NCAN at Abcam
    Cloud-Clone Corp. Antibodies for NCAN
    Search ThermoFisher Antibodies for NCAN
    LSBio Antibodies in human, mouse, rat for NCAN

    NCAN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NCAN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCAN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NCAN
    Cloud-Clone Corp. CLIAs for NCAN
    Search eBioscience for ELISAs for NCAN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands
    VSET: Immunoglobulin superfamily / V-set domain containing
    HYALECTAN: Proteoglycans / Extracellular Matrix : Hyalectans

    Selected InterPro protein domains (see all 15):
     IPR000742 EG-like_dom
     IPR000436 Sushi_SCR_CCP
     IPR000152 EGF-type_Asp/Asn_hydroxyl_site
     IPR018097 EGF_Ca-bd_CS
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O14594

    ProtoNet protein and cluster: O14594

    Selected Blocks protein domains (see all 6):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000436 Sushi domain/SCR domain/CCP module
    IPB000538 Link domain
    IPB001881 EGF-like calcium-binding
    IPB002353 Type II antifreeze protein signature


    UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594
    Similarity: Belongs to the aggrecan/versican proteoglycan family
    Similarity: Contains 1 C-type lectin domain
    Similarity: Contains 2 EGF-like domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain
    Similarity: Contains 2 Link domains
    Similarity: Contains 1 Sushi (CCP/SCR) domain


    Find genes that share domains with NCAN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCAN_HUMAN, O14594
    Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion
    molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005540hyaluronic acid binding IEA--
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with NCAN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCAN:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 3 alleles(MGI details for Ncan):
     nervous system 

    Find genes that share phenotypes with NCAN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NCAN: Ncantm3Ref Ncantm1Ref

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCAN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NCAN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCAN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCAN

    miRNA
    Products:
        
    miRTarBase miRNAs that target NCAN:
    hsa-mir-342-3p (MIRT043672)

    Block miRNA regulation of human, mouse, rat NCAN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAN (see all 39):
    hsa-miR-323-3p hsa-miR-631 hsa-miR-330-5p hsa-miR-128 hsa-miR-200a hsa-miR-218 hsa-miR-141 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidNCAN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NCAN
    Predesigned siRNA for gene silencing in human, mouse, rat NCAN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCAN

    Clone
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    OriGene clones in human, mouse for NCAN (see all 6)
    OriGene ORF clones in mouse, rat for NCAN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NCAN (NM_004386)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAN

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NCAN
    Browse ESI BIO Cell Lines and PureStem Progenitors for NCAN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCAN_HUMAN, O14594: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    golgi apparatus4
    lysosome4
    vacuole4
    plasma membrane3
    cytoskeleton2
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005796Golgi lumen TAS--
    GO:0043202lysosomal lumen TAS--

    Find genes that share ontologies with NCAN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCAN About   (see all 12)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    CS/DS degradation0.00
    A tetrasaccharide linker sequence is required for GAG synthesis0.51
    Dermatan sulfate biosynthesis0.00
    Chondroitin sulfate biosynthesis0.41
    3L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    4NCAM signaling for neurite out-growth
    NCAM1 interactions0.59
    NCAM signaling for neurite out-growth0.59
    5Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57


    Find genes that share SuperPaths with NCAN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NCAN (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    1 GeneGo (Thomson Reuters) Pathway for NCAN
        Cell adhesion Cell-matrix glycoconjugates

    2 BioSystems Pathways for NCAN
        Spinal Cord Injury
    Syndecan-3-mediated signaling events

    Selected Reactome Pathways for NCAN (see all 7)
        L1CAM interactions
    Dermatan sulfate biosynthesis
    ECM proteoglycans
    NCAM1 interactions
    CS/DS degradation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCAN
    Interactions:

        Search GeneGlobe Interaction Network for NCAN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCAN (O145942, 3 ENSP000002525754) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNTN2Q022463, ENSP000003306334I2D: score=2 STRING: ENSP00000330633
    TNCP248213, ENSP000002651314I2D: score=2 STRING: ENSP00000265131
    PTNP212463, ENSP000003411704I2D: score=1 STRING: ENSP00000341170
    TNRQ927523, ENSP000002635254I2D: score=1 STRING: ENSP00000263525
    L1CAMP320043, ENSP000003590744I2D: score=2 STRING: ENSP00000359074
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007155cell adhesion IEA--
    GO:0007411axon guidance TAS--
    GO:0030198extracellular matrix organization TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--

    Find genes that share ontologies with NCAN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCAN

    3 HMDB Compounds for NCAN    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChondroitinChondroitin-D-glucuronate (see all 5)9007-27-6--
    Chondroitin sulfateChondritinsulfate (see all 12)9007-28-7--
    Hyaluronic acidhyaluronic acid 9004-61-9--

    2 DrugBank Compounds for NCAN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Beta-D-Glucose-- 50-99-7target--17139284 17016423 10592235
    Thiodigalactoside-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCAN gene: 
    NM_004386.2  

    Unigene Cluster for NCAN:

    Neurocan
    Hs.169047  [show with all ESTs]
    Unigene Representative Sequence: NM_004386
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252575(uc002nlz.3 uc010ecc.1 uc002nma.3) ENST00000590187
    ENST00000588231 ENST00000585410 ENST00000538881
    miRNA
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    Block miRNA regulation of human, mouse, rat NCAN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAN (see all 39):
    hsa-miR-323-3p hsa-miR-631 hsa-miR-330-5p hsa-miR-128 hsa-miR-200a hsa-miR-218 hsa-miR-141 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidNCAN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NCAN
    Predesigned siRNA for gene silencing in human, mouse, rat NCAN
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NCAN (NM_004386)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NCAN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCAN
      QuantiTect SYBR Green Assays in human, mouse, rat NCAN
      QuantiFast Probe-based Assays in human, mouse, rat NCAN

    Additional mRNA sequence: 

    AB210004.1 AF026547.1 AK126639.1 AK297395.1 AK309138.1 

    5 DOTS entries:

    DT.413934  DT.87015114  DT.103427  DT.95082024  DT.97825628 

    Selected AceView cDNA sequences (see all 90):

    H13977 CR595144 CB152010 AL134615 AW297545 AA339162 AI424163 BX107820 
    AK126639 BF527638 AI570668 BF196727 CR626573 CR620706 AL134752 CB117942 
    BF527154 BF530998 AW025658 BG820182 BX493537 AI961112 AI421890 M78848 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NCAN    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                                              -                           
    SP2:                                                                          -               


    ECgene alternative splicing isoforms for NCAN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCAN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCGTGGCAC
    NCAN Expression
    About this image


    NCAN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Spinal Cord (Nervous System)
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Oligodendrocytes (Nervous System)
             Oligodendrocyte progenitor cells
    NCAN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCAN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169047

    UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594
    Tissue specificity: Brain

        Custom PCR Arrays for NCAN
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NCAN
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    QuantiFast Probe-based Assays in human, mouse, rat NCAN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NCAN gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncan1 , 5 neurocan1, 5 73.91(n)1
    70.8(a)1
      8 (34.15 cM)5
    130041  NM_007789.31  NP_031815.21 
     700930855 
    lizard
    (Anolis carolinensis)
    Reptilia NCAN6
    neurocan
    43(a)
    1 ↔ 1
    GL344241.1(17761-49226)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.202792 Transcribed sequence with weak similarity to protein more 80.84(n)    57039354 


    ENSEMBL Gene Tree for NCAN (if available)
    TreeFam Gene Tree for NCAN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCAN gene
    HAPLN32  BCAN2  CLEC19A2  HAPLN12  HAPLN42  ACAN2  VCAN2  HAPLN22  
    Selected SIMAP similar genes for NCAN using alignment to 3 protein entries:     NCAN_HUMAN (see all proteins) (see all similar genes):
    CSPG3 variant protein    DKFZp761L191    F9    ACAN    SNED1    HAPLN2
    KLRF1    NOTCH3    ASGR1    CLEC19A    CLEC4C    REG1A
    HAPLN1    KLRG1    HAPLN3    PAP    REG3A    DKFZp686H17246

    Find genes that share paralogs with NCAN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCAN (see all 986)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500572621,2
    --19320825(+) AACTCC/GTGACC 1 -- us2k10--------
    rs1477521411,2
    --19320852(+) CTTCAA/GCCTCC 1 -- us2k10--------
    rs1425066751,2
    --19321051(+) CAGGCA/GTCCGC 1 -- us2k10--------
    rs1929436611,2
    --19321186(+) AGCCAC/GGGCAC 1 -- us2k10--------
    rs1828505001,2
    --19321255(+) CTATCC/GTCCTA 1 -- us2k10--------
    rs621355051,2
    C--19321821(+) GCTCAC/TGCCTG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs621355401,2
    C--19321822(+) CTCATG/ACCTGT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs3762691121,2
    C--19321974(+) AGCTAC/TTCAGG 1 -- us2k10--------
    rs3691632991,2
    C--19321977(+) TATTCA/GGGAGG 1 -- us2k10--------
    rs3729402271,2
    C--19321988(+) CTGAGA/GCAGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCAN (19322782 - 19363061 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NCAN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911304CNV Loss21882294
    nsv911305CNV Loss21882294
    nsv911303CNV Loss21882294

    Human Gene Mutation Database (HGMD): NCAN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCAN
    DNA2.0 Custom Variant and Variant Library Synthesis for NCAN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600826    OMIM disorders: --


    Find genes that share disorders with NCAN           About GenesLikeMe

    Genetic Association Database (GAD): NCAN
    Human Genome Epidemiology (HuGE) Navigator: NCAN (6 documents)

    Export disorders for NCAN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCAN gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with NCAN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. (PubMed id 21353194)1, 3, 4 Cichon S....NAPthen M.M. (Am. J. Hum. Genet. 2011)
    2. Characterization of the human neurocan gene, CSPG3. (PubMed id 9795216)1, 2, 9 Prange C.K.... Lennon G.G. (Gene 1998)
    3. Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)1, 4 Kathiresan S....Cupples L.A. (Nat. Genet. 2009)
    4. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. (PubMed id 19148283)1, 4 Deo R.C....Wilson J.G. (PLoS Genet. 2009)
    5. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (PubMed id 19060911)1, 4 Aulchenko Y.S....Peltonen L. (Nat. Genet. 2009)
    6. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. (PubMed id 18193043)1, 4 Willer C.J....Abecasis G.R. (Nat. Genet. 2008)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. (PubMed id 1326557)1, 3 Rauch U....Margolis R.K. (J. Biol. Chem. 1992)
    9. Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity. (PubMed id 23594525)1 Gorden A....Gerhard G.S. (Hum. Hered. 2013)
    10. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (J. Proteome Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1463 HGNC: 2465 AceView: CSPG3 Ensembl:ENSG00000130287 euGenes: HUgn1463
    ECgene: NCAN H-InvDB: NCAN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NCAN Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_213

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NCAN gene:
    Search GeneIP for patents involving NCAN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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