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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NCAN Gene

protein-coding GIFtS: 62
GCID: GC19P019322

neurocan

(Previous name: chondroitin sulfate proteoglycan 3 )
(Previous symbol: CSPG3)

Explore 4 diseases affiliated with
NCAN via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neurocan¹		Neurocan Core Protein²
CSPG3¹ ² ³ ⁵		Neurocan Proteoglycan²
Chondroitin Sulfate Proteoglycan 3¹ ³		NEUR³
Chondroitin Sulfate Proteoglycan 3 (Neurocan)²

External Ids:	HGNC: 2465¹	Entrez Gene: 1463²	Ensembl: ENSG00000130287⁷	OMIM: 600826⁵	UniProtKB: O14594³

Export aliases for NCAN gene to outside databases

Previous GC identifers: GC19P019183 GC19P018887

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCAN:

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and

migration.(supplied by OMIM, Jul 2002)

UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594

Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion

molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid

Gene Wiki entry for NCAN (Neurocan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NCAN gene promoter:
Max1 SRF NRSF form 1 POU3F2 NRSF form 2 c-Ets-1 Roaz AREB6 Pax-4a c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NCAN promoter sequence

Search SABiosciences Chromatin IP Primers for NCAN

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCAN

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p12 Ensembl cytogenetic band: 19p13.11 HGNC cytogenetic band: 19p12

NCAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAN gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P019322: view genomic region (about GC identifiers)

Start:	19,322,782 bp from pter	End:	19,363,061 bp from pter
Size:	40,280 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594 (See protein sequence)

Recommended Name: Neurocan core protein precursor

Size: 1321 amino acids; 143093 Da

Subcellular location: Secreted (By similarity)

Secondary accessions: Q9UPK6

Explore the universe of human proteins at neXtProt for NCAN: NX_O14594

Post-translational modifications:

O-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14594

NCAN Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004377.2

ENSEMBL proteins:

ENSP00000252575 ENSP00000465599 ENSP00000468626 ENSP00000442202

Reactome Protein details: O14594
Human Recombinant Protein Products for NCAN:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for NCAN
	Novus Biologicals NCAN Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NCAN

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005796	Golgi lumen	TAS	--
GO:0043202	lysosomal lumen	TAS	--

NCAN for ontologies About GeneDecksing

NCAN Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NCAN
	R&D Systems Antibodies for NCAN (Neurocan)
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	Novus Biologicals NCAN Antibodies
	Abcam antibodies for NCAN
	Uscn Antibodies for NCAN
	Search ThermoFisher Antibodies for NCAN

Assay Products for NCAN:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NCAN
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NCAN

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NCAN for domains About GeneDecksing

5/15 InterPro domains/families (see all 15):

IPR007110 Ig-like_dom

IPR016187 C-type_lectin_fold

IPR001881 EGF-like_Ca-bd

IPR003599 Ig_sub

IPR000742 EG-like_dom

Graphical View of Domain Structure for InterPro Entry O14594

ProtoNet protein and cluster: O14594

5/6 Blocks protein families (see all 6):

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB000436 Sushi domain/SCR domain/CCP module

IPB000538 Link domain

IPB001881 EGF-like calcium-binding

IPB002353 Type II antifreeze protein signature

UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594

Similarity: Belongs to the aggrecan/versican proteoglycan family

Similarity: Contains 1 C-type lectin domain

Similarity: Contains 2 EGF-like domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

Similarity: Contains 2 Link domains

Similarity: Contains 1 Sushi (CCP/SCR) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NCAN_HUMAN, O14594

Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion

molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005540	hyaluronic acid binding	IEA	--
GO:0030246	carbohydrate binding	IEA	--

NCAN for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NCAN:

Increased gamma-H2AX phosphory

1 MGI mutant phenotype (inferred from 3 alleles) (MGI details for Ncan):

nervous system

NCAN for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NCAN: Ncan^tm3Ref Ncan^tm1Ref

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NCAN

miRNA Products:		OriGene 3'-UTR Clone: NCAN Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCAN
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate NCAN (see all 39):
		hsa-miR-323-3p hsa-miR-631 hsa-miR-330-5p hsa-miR-128 hsa-miR-200a hsa-miR-218 hsa-miR-141 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: NCAN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCAN (see all 7) OriGene shRNA RFP: NCAN OriGene siRNA: NCAN
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NCAN

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NCAN
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCAN (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCAN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAN

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

MPS IIIC - Sanfilippo syndrome C

8/15 pathways (see all 15)
MPS IIIC - Sanfilippo syndrome C	1.00	MPS IIID - Sanfilippo syndrome D	1.00
MPS I - Hurler syndrome	1.00	MPS IX - Natowicz syndrome	1.00
Mucopolysaccharidoses	1.00	MPS II - Hunter syndrome	1.00
MPS IV - Morquio syndrome A	1.00	Glycosaminoglycan metabolism	1.00

DSPGs are secreted

DSPG and CSPG translocate to the lysosome for degradation	1.00	CSPG is secreted	1.00
DSPGs are secreted	1.00	Dermatan sulfate biosynthesis	0.70
CS is cleaved from its proteoglycan	1.00	CS/DS degradation	0.54
DS is cleaved from its proteoglycan	1.00

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

Cell adhesion_Cell-matrix glycoconjugates

Cell adhesion_Cell-matrix glycoconjugates

1.00

Cell adhesion Cell-matrix glycoconjugates

0.97

NCAM signaling for neurite out-growth

NCAM signaling for neurite out-growth

1.00

NCAM1 interactions

0.62

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for NCAN

Cell adhesion Cell-matrix glycoconjugates

1 GeneGo (Thomson Reuters) Pathway for NCAN

Cell adhesion Cell-matrix glycoconjugates

1 BioSystems Pathway for NCAN

Syndecan-3-mediated signaling events

5/32 Reactome Pathways for NCAN (see all 32)

	L1CAM interactions
	Chondroitin sulfate/dermatan sulfate metabolism
	MPS VI - Maroteaux-Lamy syndrome
	MPS IIIA - Sanfilippo syndrome A
	DSPGs are secreted

NCAN for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NCAN

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/45 Interacting proteins for NCAN (O14594^{2, 3} ENSP00000252575⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 45)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CNTN2	Q02246³, ENSP00000330633⁴	I2D: score=2 STRING: ENSP00000330633
TNC	P24821³, ENSP00000265131⁴	I2D: score=2 STRING: ENSP00000265131
PTN	P21246³, ENSP00000341170⁴	I2D: score=1 STRING: ENSP00000341170
TNR	Q92752³, ENSP00000263525⁴	I2D: score=1 STRING: ENSP00000263525
L1CAM	P32004³, ENSP00000359074⁴	I2D: score=2 STRING: ENSP00000359074

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0007155	cell adhesion	IEA	--
GO:0007411	axon guidance	TAS	--
GO:0030203	glycosaminoglycan metabolic process	TAS	--
GO:0030204	chondroitin sulfate metabolic process	TAS	--

NCAN for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NCAN

3 HMDB Compounds for NCAN About this table

Compound	Synonyms	CAS #	PubMed Ids
Chondroitin	Chondroitin-D-glucuronate (see all 5)	9007-27-6	--
Chondroitin sulfate	Chondritinsulfate (see all 12)	9007-28-7	--
Hyaluronic acid	hyaluronic acid	9004-61-9	--

2 DrugBank Compounds for NCAN About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Beta-D-Glucose	--	50-99-7	target	--	17139284 17016423 10592235
Thiodigalactoside	--	--	target	--	17139284 17016423 10592235

Search CenterWatch for drugs/clinical trials and news about NCAN

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NCAN gene:

NM_004386.2

Unigene Cluster for NCAN:

Neurocan

Hs.169047 [show with all ESTs]

Unigene Representative Sequence: NM_004386

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000252575(uc002nlz.3 uc010ecc.1 uc002nma.3) ENST00000590187

ENST00000588231 ENST00000585410 ENST00000538881

miRNA Products:		OriGene 3'-UTR Clone: NCAN Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCAN
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate NCAN (see all 39):
		hsa-miR-323-3p hsa-miR-631 hsa-miR-330-5p hsa-miR-128 hsa-miR-200a hsa-miR-218 hsa-miR-141 hsa-miR-1184

		SwitchGear 3'UTR luciferase reporter plasmid: NCAN 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: NCAN (NM_004386)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCAN

Additional cDNA sequence:

AB210004.1 AF026547.1 AK126639.1 AK297395.1 AK309138.1

5 DOTS entries:

DT.413934 DT.87015114 DT.103427 DT.95082024 DT.97825628

24/90 AceView cDNA sequences (see all 90):

CB117942 H13977 AL134752 AA339162 CR620706 BF196727 CR626573 BF527638

AI570668 AK126639 BX107820 AI424163 AW297545 AL134615 CB152010 CR595144

BF527154 BG014077 AW590469 AW025658 BF530998 BG820182 BX478732 BG911478

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NCAN About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14
SP1:																					-
SP2:																									-

ECgene alternative splicing isoforms for NCAN

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NCAN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCGTGGCAC

About this image

NCAN expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Neural Tube

Presumptive Spinal Cord

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NCAN Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCAN

SOURCE GeneReport for Unigene cluster: Hs.169047

UniProtKB/Swiss-Prot: NCAN_HUMAN, O14594

Tissue specificity: Brain

SABiosciences Custom PCR Arrays for NCAN

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCAN
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCAN

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCAN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NCAN gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NCAN¹	neurocan	57.71(n) 52.85(a)		395493 NM_204740.1 NP_990071.1
lizard (Anolis carolinensis)	Reptilia	NCAN⁶	--	44(a)	1 ↔ 1	GL344241.1(17761-44009)
zebrafish (Danio rerio)	Actinopterygii	Dr.20279²	Transcribed sequence with weak similarity to protein more	80.84(n)		57039354

ENSEMBL Gene Tree for NCAN (if available)
TreeFam Gene Tree for NCAN (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NCAN gene

HAPLN1² HAPLN4² HAPLN3² ACAN² BCAN² VCAN² HAPLN2²

18/23 SIMAP similar genes for NCAN using alignment to 4 protein entries: NCAN_HUMAN (see all proteins) (see all similar genes):

CSPG3 variant protein ACAN DKFZp761L191 F9 SNED1 HAPLN2

KLRF1 NOTCH3 ASGR1 CLEC19A CLEC4C REG1A

HAPLN1 KLRG1 HAPLN3 PAP REG3A DKFZp686H17246

NCAN for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs80310067^1,2		--	18914692(+)	`CTCCTC/TCCCCT`	1	--	int¹		1		WA	118
rs150057262^1,2		--	19320825(+)	`AACTCC/GTGACC`	1	--	us2k¹		0	--	--	--	--
rs147752141^1,2		--	19320852(+)	`CTTCAA/GCCTCC`	1	--	us2k¹		0	--	--	--	--
rs142506675^1,2		--	19321051(+)	`CAGGCA/GTCCGC`	1	--	us2k¹		0	--	--	--	--
rs192943661^1,2		--	19321186(+)	`AGCCAC/GGGCAC`	1	--	us2k¹		0	--	--	--	--
rs182850500^1,2		--	19321255(+)	`CTATCC/GTCCTA`	1	--	us2k¹		0	--	--	--	--
rs62135505^1,2	C	--	19321821(+)	`GCTCAC/TGCCTG`	1	--	us2k¹		1		NA	2
rs62135540^1,2	C	--	19321822(+)	`CTCATG/ACCTGT`	1	--	us2k¹		1		NA	2
rs146000915^1,2		--	19322391(+)	`AATTGC/TAGCCA`	1	--	us2k¹		0	--	--	--	--
rs187976205^1,2		--	19322415(+)	`CGTGAA/GTCCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NCAN (19322782 - 19363061 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NCAN: --
Human Gene Mutation Database (HGMD): NCAN

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NCAN

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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NCAN for disorders           About GeneDecksing

OMIM gene information: 600826    OMIM disorders: --

4 diseases for NCAN:    About MalaCards

coronary heart disease bipolar disorder schizophrenia neuronitis

Human Genome Epidemiology (HuGE) Navigator: NCAN (6 documents)

Export disorders for NCAN gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NCAN gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with NCAN)

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Characterization of the human neurocan gene, CSPG3. (PubMed id 9795216)^{1, 2, 9} Prange C.K.... Lennon G.G. (1998)
Genome-wide association study identifies genetic vari ation in neurocan as a susceptibility factor for bipolar disorder. (PubMed id 21353194)^{1, 3} Cichon S....NAPthen M.M. (2011)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. (PubMed id 1326557)^{1, 3} Rauch U....Margolis R.K. (1992)
LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)² Halim A.... Nilsson J. (2013)
Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder. (PubMed id 22497794)¹ Muhleisen T.W....Cichon S. (2012)
Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. (PubMed id 21997179)¹ Varga I....Klekner A. (2012)
Studies in humans and mice implicate neurocan in the e tiology of mania. (PubMed id 22952076)¹ Miro X....Zimmer A. (2012)
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associa ted with disease risk and cortical surface area. (PubMed id 20950796)¹ KAohler A.K....Andreassen O.A. (2011)
Sex-specific association of rs16996148 SNP in the NCAN /CILP2/PBX4 and serum lipid levels in the Mulao and Han populations. (PubMed id 22208664)¹ Yan T.T....Pan S.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1463	HGNC: 2465	AceView: CSPG3	Ensembl:ENSG00000130287	euGenes: HUgn1463
ECgene: NCAN	H-InvDB: NCAN

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NCAN	Pharmacogenomics, SNPs, Pathways
Functional Glycomics Gateway - Glycan Binding	http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_213

Intellectual Property for NCAN gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NCAN gene:
Search GeneIP for patents involving NCAN

GeneCards and IP:
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