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NCAM2 Gene

protein-coding   GIFtS: 61
GCID: GC21P022370

Neural Cell Adhesion Molecule 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Neural Cell Adhesion Molecule 21 2
N-CAM-22 3
NCAM-22 3
NCAM212 3
Neural Cell Adhesion Molecule 2 Precursor11

External Ids:    HGNC: 76571   Entrez Gene: 46852   Ensembl: ENSG000001546547   OMIM: 6020405   UniProtKB: O153943   

Export aliases for NCAM2 gene to outside databases

Previous GC identifers: GC21P019231 GC21P019032 GC21P021292 GC21P007759


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NCAM2 Gene:
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and
may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NCAM2 Gene:
NCAM2 (neural cell adhesion molecule 2) is a protein-coding gene. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
Function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory
axons




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NCAM2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCAM2 promoter sequence

   Search Chromatin IP Primers for NCAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NCAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21
Nature(405: 311-319) cytogenetic band:   21q21.1
NCAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAM2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P022370:   GeneLoc Nature:405,311-319
Start:
22,370,633 bp from pter       8,232,569 bp from centromere
End:
22,915,650 bp from pter 8,490,122 bp from centromere
Size:
545,018 bases 257,554 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: U75330
genomic clones: R636L7 to 21B42C4


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394 (See protein sequence)
Recommended Name: Neural cell adhesion molecule 2 precursor  
Size: 837 amino acids; 93046 Da
Selected PDB 3D structures from and Proteopedia for NCAM2 (see all 9):
2DOC (3D)        2JLL (3D)        2KBG (3D)        2V5T (3D)        2VAJ (3D)        2WIM (3D)    
Secondary accessions: A8MQ06 Q7Z7F2

Explore the universe of human proteins at neXtProt for NCAM2: NX_O15394

Explore proteomics data for NCAM2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn177, Asn219, Asn309, Asn406, Asn419, Asn445, Asn474, Asn562
  • Modification sites at PhosphoSitePlus

  • See NCAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004531.2  
    ENSEMBL proteins: 
     ENSP00000383392   ENSP00000284894   ENSP00000441887  

    NCAM2 Human Recombinant Protein Products:

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    antibodies-online proteins for NCAM2 (4 products) 

     
    antibodies-online peptides for NCAM2

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    antibodies-online antibodies for NCAM2 (54 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR009138 Neural_cell_adh
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry O15394

    ProtoNet protein and cluster: O15394

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB009138 Neural cell adhesion molecule signature


    UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    Find genes that share domains with NCAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCAM2_HUMAN, O15394
    Function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory
    axons

         Genatlas biochemistry entry for NCAM2:
    cell adhesion molecule,neural,2,immunoglobulin superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NCAM2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NCAM2:
     Increased homologous recombina 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ncam2):
     nervous system  normal  taste/olfaction 

    Find genes that share phenotypes with NCAM2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ncam2tm1Mom for NCAM2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NCAM2
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    miRNA
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    miRTarBase miRNAs that target NCAM2:
    hsa-mir-335-5p (MIRT018062), hsa-mir-26b-5p (MIRT029650)

    Block miRNA regulation of human, mouse, rat NCAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAM2 (see all 28):
    hsa-miR-448 hsa-miR-4311 hsa-miR-495 hsa-miR-16-2* hsa-miR-340 hsa-miR-1297 hsa-miR-133a hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNCAM2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NCAM2

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    GenScript: all cDNA clones in your preferred vector: NCAM2 (NM_004540)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCAM2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NCAM2_HUMAN, O15394: Cell membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030424axon IEA--

    Find genes that share ontologies with NCAM2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NCAM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Prion diseases
    Prion diseases
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with NCAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for NCAM2):
        Cell adhesion molecules (CAMs)
    Prion diseases

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NCAM2
    Interactions:

        Search GeneGlobe Interaction Network for NCAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NCAM2 (O153943 ENSP000003833924) via UniProtKB, MINT, STRING, and/or I2D (see all 164)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC1Q9H1A43, ENSP000003391094I2D: score=1 STRING: ENSP00000339109
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    BCAP31P515723, ENSP000003923304I2D: score=1 STRING: ENSP00000392330
    CLASRPQ8N2M83, ENSP000002214554I2D: score=1 STRING: ENSP00000221455
    FLIIQ130453, ENSP000003245734I2D: score=1 STRING: ENSP00000324573
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007158neuron cell-cell adhesion TAS9226371
    GO:0007413axonal fasciculation IEA--
    GO:0007608sensory perception of smell IEA--

    Find genes that share ontologies with NCAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NCAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NCAM2 gene: 
    NM_004540.3  

    Unigene Cluster for NCAM2:

    Neural cell adhesion molecule 2
    Hs.473450  [show with all ESTs]
    Unigene Representative Sequence: NM_004540
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400546(uc002yld.2 uc011acb.2) ENST00000486367 ENST00000461281
    ENST00000484983 ENST00000284894 ENST00000535285(uc011acc.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat NCAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NCAM2 (see all 28):
    hsa-miR-448 hsa-miR-4311 hsa-miR-495 hsa-miR-16-2* hsa-miR-340 hsa-miR-1297 hsa-miR-133a hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNCAM2 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK299054.1 AK302870.1 AL137344.1 BC036088.1 BC052946.1 

    4 DOTS entries:

    DT.310937  DT.121136095  DT.40119178  DT.95357462 

    Selected AceView cDNA sequences (see all 85):

    BU580655 BP371109 AL120407 Z39816 BP357558 F06760 AL138049 BM729225 
    F03927 AA709271 BM666325 AA382726 AL120485 NM_004540 BM682143 AA234378 
    BM835913 BQ717550 BC052946 Z38354 BI850232 AI306467 CF122435 BC036088 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NCAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTATGAGTC
    NCAM2 Expression
    About this image


    NCAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             PureStem 7SMOO32, NCr-fac & Meso Progenitor
     
     Oligodendrocytes (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Oligodendrocyte-like cells
    NCAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NCAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473450

    UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
    Tissue specificity: Expressed most strongly in adult and fetal brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NCAM2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncam21 , 5 neural cell adhesion molecule 21, 5 86.85(n)1
    93.57(a)1
      16 (45.89 cM)5
    179681  NM_001113208.11  NP_001106679.11 
     812006975 
    chicken
    (Gallus gallus)
    Aves NCAM21 neural cell adhesion molecule 2 81.72(n)
    87.26(a)
      427968  XM_425540.4  XP_425540.4 
    lizard
    (Anolis carolinensis)
    Reptilia NCAM26
    neural cell adhesion molecule 2
    77(a)
    1 ↔ 1
    3(150962412-151137572)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.118522 Transcribed sequence with moderate similarity to protein more 77.47(n)    BX725298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncam22 neural cell adhesion molecule 2 72.44(n)   114441  AY029403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fas23 homophilic cell adhesion 29(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea ncam-16
    Protein NCAM-1, isoform a (ncam-1) mRNA, complete ...
    20(a)
    1 → many
    X(692978-703036) WBGene00017184


    ENSEMBL Gene Tree for NCAM2 (if available)
    TreeFam Gene Tree for NCAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NCAM2 gene
    IGSF102  PTK72  ENSG000002154282  MXRA52  NCAM12  
    4 SIMAP similar genes for NCAM2 using alignment to 5 protein entries:     NCAM2_HUMAN (see all proteins):
    NCAM1    K-SAM    CNTN4    HMCN2

    Find genes that share paralogs with NCAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NCAM2 (see all 12412)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668434061,2
    C--12979360(+) GGCCA-/TT    
       
    /TTTT
    TTTTT
    1 -- int11NA 2
    rs732281291,2
    C--22368642(+) AGTCAC/TTTTGC 1 -- us2k10--------
    rs770305851,2
    C,F--22368664(+) ATTTAC/TGTTAT 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs788990131,2
    C--22368682(+) GTATC-/TTTGTTT 1 -- us2k10--------
    rs792244341,2
    C--22368683(+) TATCA-/TTGTTTC 1 -- us2k10--------
    rs1117171281,2
    C,F--22368719(+) CCATGG/ATTGGT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1396400841,2
    C--22368748(+) ACTGT-/GGA   
       CGCAG
    AAGGC
    1 -- us2k10--------
    rs1856926911,2
    --22368755(+) ACGCAA/GAAGGC 1 -- us2k10--------
    rs1137039851,2
    C,F--22368767(+) TACTGT/AGTAGC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1901511081,2
    --22368798(+) AATGAA/GGAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCAM2 (22370633 - 22620633 bp, first 250kb of NCAM2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NCAM2 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657272CNV Deletion23128226
    esv2723244CNV Deletion23290073
    esv2723243CNV Deletion23290073
    esv2662138CNV Deletion23128226
    esv2462157CNV Deletion19546169
    esv1433890CNV Insertion17803354
    nsv507916CNV Insertion20534489
    esv991118CNV Insertion20482838
    esv1743038CNV Insertion17803354
    esv1111053CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NCAM2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602040    OMIM disorders: --


    Find genes that share disorders with NCAM2           About GenesLikeMe

    Genetic Association Database (GAD): NCAM2
    Human Genome Epidemiology (HuGE) Navigator: NCAM2 (5 documents)

    Export disorders for NCAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NCAM2 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NCAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. (PubMed id 9226371)1, 2, 3 Paoloni-Giacobino A.... Antonarakis S.E. (Genomics 1997)
    2. A genome-wide association study on obesity and obesity-related traits. (PubMed id 21552555)1, 4 Wang K....Price R.A. (PLoS ONE 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association reveals genetic effects on human AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1, 4 Han M.R....Wang L.S. (BMC Neurol 2010)
    5. Joint influence of small-effect genetic variants on human longevity. (PubMed id 20834067)1, 4 Yashin A.I....Ukraintseva S.V. (Aging (Albany NY) 2010)
    6. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)
    8. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    9. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    10. Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy. (PubMed id 21214674)1 Takahashi S....Hamada H. (Cancer Sci. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4685 HGNC: 7657 AceView: NCAM2 Ensembl:ENSG00000154654 euGenes: HUgn4685
    ECgene: NCAM2 Kegg: 4685 H-InvDB: NCAM2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NCAM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCAM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NCAM2 gene:
    Search GeneIP for patents involving NCAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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