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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCAM2 Gene

protein-coding   GIFtS: 57
GCID: GC21P022370

neural cell adhesion molecule 2

 Explore 7 diseases affiliated with
NCAM2 via our new
 Human Malady Compendium 
Biological research products
for NCAM2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Neural Cell Adhesion Molecule 21 2
NCAM211 2 3
N-CAM-22 3
NCAM-22 3
MGC510081
Neural Cell Adhesion Molecule 2 Precursor11

External Ids:    HGNC: 76571   Entrez Gene: 46852   Ensembl: ENSG000001546547   OMIM: 6020405   UniProtKB: O153943   

Export aliases for NCAM2 gene to outside databases

Previous GC identifers: GC21P019231 GC21P019032 GC21P021292 GC21P007759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCAM2:
The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may
function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
Function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory
axons




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011512.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCAM2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCAM2 promoter sequence

   Search SABiosciences Chromatin IP Primers for NCAM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q21.1   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q21
Nature(405: 311-319) cytogenetic band:   21q21.1
NCAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCAM2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P022370:   GeneLoc Nature:405,311-319
Start:
22,370,633 bp from pter       8,232,569 bp from centromere
End:
22,915,650 bp from pter 8,490,122 bp from centromere
Size:
545,018 bases 257,554 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: U75330
genomic clones: R636L7 to 21B42C4


(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394 (See protein sequence)
Recommended Name: Neural cell adhesion molecule 2 precursor  
Size: 837 amino acids; 93046 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein
6/9 PDB 3D structures from and Proteopedia for NCAM2 (see all 9):
2DOC (3D)        2JLL (3D)        2KBG (3D)        2V5T (3D)        2VAJ (3D)        2WIM (3D)    
Secondary accessions: A8MQ06 Q7Z7F2

Explore the universe of human proteins at neXtProt for NCAM2: NX_O15394

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15394

  • NCAM2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004531.2  
    ENSEMBL proteins: 
     ENSP00000383392   ENSP00000284894   ENSP00000441887  

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    Uscn Proteins for NCAM2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030424axon IEA--


    NCAM2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NCAM2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR009138 Neural_cell_adh

    Graphical View of Domain Structure for InterPro Entry O15394

    ProtoNet protein and cluster: O15394

    2 Blocks protein families:
    IPB003598 Immunoglobulin C-2 type
    IPB009138 Neural cell adhesion molecule signature


    UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
    Similarity: Contains 2 fibronectin type-III domains
    Similarity: Contains 5 Ig-like C2-type (immunoglobulin-like) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
    Function: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory
    axons

         Genatlas biochemistry entry for NCAM2:
    cell adhesion molecule,neural,2,immunoglobulin superfamily

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate NCAM2 (see all 28):
    hsa-miR-448 hsa-miR-4311 hsa-miR-495 hsa-miR-16-2* hsa-miR-340 hsa-miR-1297 hsa-miR-133a hsa-miR-7-1*
    SwitchGear 3'UTR luciferase reporter plasmidNCAM2 3' UTR sequence
    Inhib. RNA
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    1 GenomeRNAi human phenotype for NCAM2:
     Increased homologous recombina 

    Animal Models:
         Mouse knock-out Ncam2tm1Mom for NCAM2
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ncam2):
     nervous system  normal  taste/olfaction 

    NCAM2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Prion diseases
    Prion diseases1.00
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for NCAM2):
        Cell adhesion molecules (CAMs)
    Prion diseases


    NCAM2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/98 Interacting proteins for NCAM2 (O153943 ENSP000003833924) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL17P186213I2D: score=1 
    RPL17-C18orf32P186213I2D: score=1 
    PRNPP041563I2D: score=2 
    ABT1Q9ULW33I2D: score=1 
    ACO1P213993I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007158neuron cell-cell adhesion TAS9226371


    NCAM2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCAM2
    Search CenterWatch for drugs/clinical trials and news about NCAM2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCAM2 gene: 
    NM_004540.3  

    Unigene Cluster for NCAM2:

    Neural cell adhesion molecule 2
    Hs.473450  [show with all ESTs]
    Unigene Representative Sequence: NM_004540
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400546(uc002yld.2 uc011acb.2) ENST00000508782 ENST00000486367
    ENST00000461281 ENST00000484983 ENST00000284894 ENST00000535285(uc011acc.2)


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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate NCAM2 (see all 28):
    hsa-miR-448 hsa-miR-4311 hsa-miR-495 hsa-miR-16-2* hsa-miR-340 hsa-miR-1297 hsa-miR-133a hsa-miR-7-1*
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    Additional cDNA sequence: 

    AK299054.1 AK302870.1 AL137344.1 BC036088.1 BC052946.1 

    4 DOTS entries:

    DT.310937  DT.121136095  DT.40119178  DT.95357462 

    24/85 AceView cDNA sequences (see all 85):

    BM835913 AA234378 AA382726 BM729225 BM666325 AL120485 AL138049 BU580655 
    BM682143 F06760 BC052946 BQ717550 AL120407 NM_004540 Z38354 AA709271 
    F03927 Z39816 BP357558 BP371109 AI207079 Z42071 AL137344 BM711312 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTATGAGTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    NCAM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NCAM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCAM2

    SOURCE GeneReport for Unigene cluster: Hs.473450

    UniProtKB/Swiss-Prot: NCAM2_HUMAN, O15394
    Tissue specificity: Expressed most strongly in adult and fetal brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NCAM2 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NCAM21 neural cell adhesion molecule 2 81.66(n)
    87.29(a)
      427968  XM_425540.3  XP_425540.3 
    lizard
    (Anolis carolinensis)
    Reptilia NCAM26
    --
    78(a)
    1 ↔ 1
    3(150962412-151137572)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.118522 Transcribed sequence with moderate similarity to protein more 77.47(n)    BX725298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncam22 neural cell adhesion molecule 2 72.44(n)   114441  AY029403.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fas21 , 3 homophilic cell adhesion3
    Fasciclin 21
    29(a)3
    41.17(n)1
    30.2(a)1
      313641  NM_080327.21  NP_525066.11 


    ENSEMBL Gene Tree for NCAM2 (if available)
    TreeFam Gene Tree for NCAM2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCAM2 gene
    NTM2  NEGR12  IGLON52  LSAMP2  NCAM12  OPCML2  
    4 SIMAP similar genes for NCAM2 using alignment to 5 protein entries:     NCAM2_HUMAN (see all proteins):
    NCAM1    K-SAM    CNTN4    HMCN2

    NCAM2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/10723 NCBI SNPs in NCAM2 are shown (see all 10723    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351307941,2
    C--8126204(+) TCTAC-/TTTTTT 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs732281291,2
    C,--22368642(+) AGTCAC/TTTTGC 1 -- us2k10--------
    rs770305851,2
    F,--22368664(+) ATTTAC/TGTTAT 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs788990131,2
    C,--22368682(+) GTATC-/TTTGTTT 1 -- us2k10--------
    rs792244341,2
    C,--22368683(+) TATCA-/TTGTTTC 1 -- us2k10--------
    rs1117171281,2
    --22368719(+) CCATGG/ATTGGT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1396400841,2
    C,--22368748(+) ACTGT-/GGA   
       CGCAG
    AAGGC
    1 -- us2k10--------
    rs1856926911,2
    --22368755(+) ACGCAA/GAAGGC 1 -- us2k10--------
    rs1137039851,2
    --22368767(+) TACTGT/AGTAGC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1901511081,2
    --22368798(+) AATGAA/GGAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NCAM2 (22370633 - 22620633 bp, first 250kb of NCAM2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for NCAM2
         6 CNVs: 9831 59040 0330 23637 9325 103050
         1 Indel: 33721

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NCAM2 for disorders           About GeneDecksing

    OMIM gene information: 602040    OMIM disorders: --

    7 diseases for NCAM2:    About MalaCards
    chronic interstitial cystitis    prion disease    down syndrome    breast cancer
    obesity    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NCAM2 (5 documents)

    Export disorders for NCAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCAM2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with NCAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. (PubMed id 9226371)1, 2, 3 Paoloni-Giacobino A.... Antonarakis S.E. (1997)
    2. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    3. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    5. Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy. (PubMed id 21214674)1 Takahashi S....Hamada H. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule. (PubMed id 21300289)1 Kulahin N....Gajhede M. (2011)
    8. A genome-wide association study on obesity and obesit y-related traits. (PubMed id 21552555)1 Wang K....Price R.A. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Genome-wide association reveals genetic effects on hu man AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PubMed id 20932310)1 Han M.R....Wang L.S. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4685 HGNC: 7657 AceView: NCAM2 Ensembl:ENSG00000154654 euGenes: HUgn4685
    ECgene: NCAM2 Kegg: 4685 H-InvDB: NCAM2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCAM2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NCAM2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCAM2 gene:
    Search GeneIP for patents involving NCAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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