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Aliases for NCAM2 Gene

Aliases for NCAM2 Gene

  • Neural Cell Adhesion Molecule 2 2 3
  • N-CAM-2 3 4
  • NCAM-2 3 4
  • NCAM21 3 4

External Ids for NCAM2 Gene

Previous GeneCards Identifiers for NCAM2 Gene

  • GC21P019231
  • GC21P019032
  • GC21P021292
  • GC21P022370
  • GC21P007759

Summaries for NCAM2 Gene

Entrez Gene Summary for NCAM2 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCAM2 Gene

NCAM2 (Neural Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs) and Prion diseases. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot for NCAM2 Gene

  • May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM2 Gene

Genomics for NCAM2 Gene

Regulatory Elements for NCAM2 Gene

Transcription factor binding sites by QIAGEN in the NCAM2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCAM2 Gene

20,998,315 bp from pter
21,543,329 bp from pter
545,015 bases
Plus strand

Genomic View for NCAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM2 Gene

Proteins for NCAM2 Gene

  • Protein details for NCAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neural cell adhesion molecule 2
    Protein Accession:
    Secondary Accessions:
    • A8MQ06
    • B7Z841
    • Q7Z7F2

    Protein attributes for NCAM2 Gene

    837 amino acids
    Molecular mass:
    93046 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NCAM2 Gene

    Alternative splice isoforms for NCAM2 Gene


neXtProt entry for NCAM2 Gene

Proteomics data for NCAM2 Gene at MOPED

Post-translational modifications for NCAM2 Gene

  • Glycosylation at Asn177, Asn219, Asn309, Asn406, Asn419, Asn445, Asn474, and Asn562
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NCAM2 Gene

Domains for NCAM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 fibronectin type-III domains.
  • Contains 2 fibronectin type-III domains.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with NCAM2: view

Function for NCAM2 Gene

Molecular function for NCAM2 Gene

GENATLAS Biochemistry:
cell adhesion molecule,neural,2,immunoglobulin superfamily
UniProtKB/Swiss-Prot Function:
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons

Gene Ontology (GO) - Molecular Function for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with NCAM2: view

Phenotypes for NCAM2 Gene

genes like me logo Genes that share phenotypes with NCAM2: view

Animal Models for NCAM2 Gene

MGI Knock Outs for NCAM2:

Animal Model Products

miRNA for NCAM2 Gene

miRTarBase miRNAs that target NCAM2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAM2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NCAM2 Gene

Localization for NCAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NCAM2 Gene COMPARTMENTS Subcellular localization image for NCAM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NCAM2: view

Pathways for NCAM2 Gene

genes like me logo Genes that share pathways with NCAM2: view

Pathways by source for NCAM2 Gene

2 KEGG pathways for NCAM2 Gene

Interacting Proteins for NCAM2 Gene

Gene Ontology (GO) - Biological Process for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007158 neuron cell-cell adhesion TAS 9226371
GO:0007413 axonal fasciculation IEA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with NCAM2: view

Transcripts for NCAM2 Gene

Unigene Clusters for NCAM2 Gene

Neural cell adhesion molecule 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAM2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM2 Gene

No ASD Table

Relevant External Links for NCAM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCAM2 Gene

mRNA expression in normal human tissues for NCAM2 Gene

mRNA differential expression in normal tissues according to GTEx for NCAM2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.0), Brain - Frontal Cortex (BA9) (5.0), Brain - Amygdala (5.0), Brain - Hippocampus (4.7), Brain - Hypothalamus (4.2), and Brain - Cortex (4.1).

Protein differential expression in normal tissues for NCAM2 Gene

This gene is overexpressed in Serum (20.2), Brain (17.7), and Frontal cortex (15.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAM2 Gene

SOURCE GeneReport for Unigene cluster for NCAM2 Gene Hs.473450

mRNA Expression by UniProt/SwissProt for NCAM2 Gene

Tissue specificity: Expressed most strongly in adult and fetal brain
genes like me logo Genes that share expressions with NCAM2: view

Primer Products

In Situ Assay Products

No data available for Expression partners for NCAM2 Gene

Orthologs for NCAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NCAM2 35
  • 92.56 (n)
  • 95.87 (a)
NCAM2 36
  • 95 (a)
(Canis familiaris)
Mammalia NCAM2 35
  • 93 (n)
  • 96.48 (a)
NCAM2 36
  • 95 (a)
(Mus musculus)
Mammalia Ncam2 35
  • 86.85 (n)
  • 93.57 (a)
Ncam2 16
Ncam2 36
  • 94 (a)
(Pan troglodytes)
Mammalia NCAM2 35
  • 99.36 (n)
  • 99.28 (a)
NCAM2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ncam2 35
  • 86.08 (n)
  • 92.96 (a)
(Monodelphis domestica)
Mammalia NCAM2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia NCAM2 36
  • 86 (a)
(Gallus gallus)
Aves NCAM2 35
  • 81.72 (n)
  • 87.26 (a)
NCAM2 36
  • 86 (a)
(Anolis carolinensis)
Reptilia NCAM2 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam2 35
  • 74.62 (n)
  • 76.36 (a)
Str.11852 35
(Danio rerio)
Actinopterygii ncam2 35
zgc:152904 35
  • 63.14 (n)
  • 66.17 (a)
ncam2 36
  • 61 (a)
NCAM2 (2 of 2) 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fas2 37
  • 29 (a)
CG15630 36
  • 22 (a)
CG33543 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea ncam-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for NCAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM2 Gene

Gene Tree for NCAM2 (if available)
Gene Tree for NCAM2 (if available)

Paralogs for NCAM2 Gene

Paralogs for NCAM2 Gene

(4) SIMAP similar genes for NCAM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NCAM2: view

Variants for NCAM2 Gene

Sequence variations from dbSNP and Humsavar for NCAM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1598 -- 21,183,766(-) TACTA(C/T)ACAGT intron-variant
rs114308 -- 21,484,961(+) ACTTT(G/T)TAAAA intron-variant, utr-variant-3-prime
rs114309 -- 21,485,404(+) AGAAT(C/T)CTTGC intron-variant, utr-variant-3-prime
rs128594 -- 21,457,849(+) caaaa(A/G)ggatg intron-variant
rs128595 -- 21,458,073(+) GTTCA(A/G)GTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAM2 Gene

Variant ID Type Subtype PubMed ID
esv2751925 CNV Loss 17911159
nsv821690 CNV Loss 15273396
dgv4696n71 CNV Loss 21882294
esv2723243 CNV Deletion 23290073
nsv9859 CNV Loss 18304495
nsv913500 CNV Loss 21882294
nsv913501 CNV Loss 21882294
nsv507916 CNV Insertion 20534489
esv991118 CNV Insertion 20482838
esv1743038 CNV Insertion 17803354
esv2723244 CNV Deletion 23290073
nsv913502 CNV Loss 21882294
nsv913503 CNV Loss 21882294
nsv828838 CNV Gain 20364138
nsv913504 CNV Loss 21882294
esv1111053 CNV Insertion 17803354
esv2662138 CNV Deletion 23128226
esv2657272 CNV Deletion 23128226
esv1433890 CNV Insertion 17803354
esv259744 OTHER Complex 20981092
nsv913505 CNV Loss 21882294
nsv913506 CNV Loss 21882294
nsv521484 CNV Loss 19592680
nsv913507 CNV Loss 21882294
nsv820109 CNV Gain 19587683
nsv913508 CNV Loss 21882294
dgv4697n71 CNV Loss 21882294
dgv4698n71 CNV Loss 21882294
nsv470889 CNV Gain 18288195
dgv4699n71 CNV Loss 21882294
dgv4700n71 CNV Loss 21882294
nsv817920 CNV Gain 17921354
nsv913517 CNV Gain 21882294
nsv459135 CNV Loss 19166990
nsv510497 CNV Loss 20534489
esv2462157 CNV Deletion 19546169

Relevant External Links for NCAM2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM2 Gene

Disorders for NCAM2 Gene

Relevant External Links for NCAM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for NCAM2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NCAM2 Gene

Publications for NCAM2 Gene

  1. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. (PMID: 9226371) Paoloni-Giacobino A. … Antonarakis S.E. (Genomics 1997) 2 3 4
  2. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H. … Aebersold R. (Nat. Biotechnol. 2003) 3 4
  3. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 48
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for NCAM2 Gene

Sources for NCAM2 Gene

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