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Aliases for NCAM2 Gene

Aliases for NCAM2 Gene

  • Neural Cell Adhesion Molecule 2 2 3 5
  • N-CAM-2 3 4
  • NCAM-2 3 4
  • NCAM21 3 4

External Ids for NCAM2 Gene

Previous GeneCards Identifiers for NCAM2 Gene

  • GC21P019231
  • GC21P019032
  • GC21P021292
  • GC21P022370
  • GC21P007759

Summaries for NCAM2 Gene

Entrez Gene Summary for NCAM2 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCAM2 Gene

NCAM2 (Neural Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs) and Prion diseases. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot for NCAM2 Gene

  • May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM2 Gene

Genomics for NCAM2 Gene

Regulatory Elements for NCAM2 Gene

Enhancers for NCAM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCAM2 on UCSC Golden Path with GeneCards custom track

Promoters for NCAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCAM2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NCAM2 gene promoter:

Genomic Location for NCAM2 Gene

20,998,315 bp from pter
21,543,329 bp from pter
545,015 bases
Plus strand

Genomic View for NCAM2 Gene

Genes around NCAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM2 Gene

Proteins for NCAM2 Gene

  • Protein details for NCAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neural cell adhesion molecule 2
    Protein Accession:
    Secondary Accessions:
    • A8MQ06
    • B7Z841
    • Q7Z7F2

    Protein attributes for NCAM2 Gene

    837 amino acids
    Molecular mass:
    93046 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NCAM2 Gene

    Alternative splice isoforms for NCAM2 Gene


neXtProt entry for NCAM2 Gene

Proteomics data for NCAM2 Gene at MOPED

Post-translational modifications for NCAM2 Gene

  • Glycosylation at Asn 177, Asn 219, Asn 309, Asn 406, Asn 419, Asn 445, Asn 474, and Asn 562
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NCAM2 Gene

Domains & Families for NCAM2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 fibronectin type-III domains.
  • Contains 2 fibronectin type-III domains.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with NCAM2: view

Function for NCAM2 Gene

Molecular function for NCAM2 Gene

GENATLAS Biochemistry:
cell adhesion molecule,neural,2,immunoglobulin superfamily
UniProtKB/Swiss-Prot Function:
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
genes like me logo Genes that share phenotypes with NCAM2: view

Animal Models for NCAM2 Gene

MGI Knock Outs for NCAM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCAM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM2 Gene

Localization for NCAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NCAM2 Gene COMPARTMENTS Subcellular localization image for NCAM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NCAM2: view

Pathways & Interactions for NCAM2 Gene

genes like me logo Genes that share pathways with NCAM2: view

Pathways by source for NCAM2 Gene

2 KEGG pathways for NCAM2 Gene

Interacting Proteins for NCAM2 Gene

Gene Ontology (GO) - Biological Process for NCAM2 Gene


No data available for SIGNOR curated interactions for NCAM2 Gene

Drugs & Compounds for NCAM2 Gene

No Compound Related Data Available

Transcripts for NCAM2 Gene

Unigene Clusters for NCAM2 Gene

Neural cell adhesion molecule 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM2 Gene

No ASD Table

Relevant External Links for NCAM2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCAM2 Gene

mRNA expression in normal human tissues for NCAM2 Gene

mRNA differential expression in normal tissues according to GTEx for NCAM2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.0), Brain - Amygdala (x5.0), Brain - Hippocampus (x4.7), Brain - Hypothalamus (x4.2), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for NCAM2 Gene

This gene is overexpressed in Serum (20.2), Brain (17.7), and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NCAM2 Gene

SOURCE GeneReport for Unigene cluster for NCAM2 Gene Hs.473450

mRNA Expression by UniProt/SwissProt for NCAM2 Gene

Tissue specificity: Expressed most strongly in adult and fetal brain.
genes like me logo Genes that share expression patterns with NCAM2: view

Primer Products

No data available for Protein tissue co-expression partners for NCAM2 Gene

Orthologs for NCAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NCAM2 35
  • 92.56 (n)
  • 95.87 (a)
NCAM2 36
  • 95 (a)
(Canis familiaris)
Mammalia NCAM2 35
  • 93 (n)
  • 96.48 (a)
NCAM2 36
  • 95 (a)
(Mus musculus)
Mammalia Ncam2 35
  • 86.85 (n)
  • 93.57 (a)
Ncam2 16
Ncam2 36
  • 94 (a)
(Pan troglodytes)
Mammalia NCAM2 35
  • 99.36 (n)
  • 99.28 (a)
NCAM2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ncam2 35
  • 86.08 (n)
  • 92.96 (a)
(Monodelphis domestica)
Mammalia NCAM2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia NCAM2 36
  • 86 (a)
(Gallus gallus)
Aves NCAM2 35
  • 81.72 (n)
  • 87.26 (a)
NCAM2 36
  • 86 (a)
(Anolis carolinensis)
Reptilia NCAM2 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam2 35
  • 74.62 (n)
  • 76.36 (a)
Str.11852 35
(Danio rerio)
Actinopterygii ncam2 35
zgc:152904 35
  • 63.14 (n)
  • 66.17 (a)
ncam2 36
  • 61 (a)
NCAM2 (2 of 2) 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fas2 37
  • 29 (a)
CG15630 36
  • 22 (a)
CG33543 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea ncam-1 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for NCAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM2 Gene

Gene Tree for NCAM2 (if available)
Gene Tree for NCAM2 (if available)

Paralogs for NCAM2 Gene

Paralogs for NCAM2 Gene

(4) SIMAP similar genes for NCAM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NCAM2: view

Variants for NCAM2 Gene

Sequence variations from dbSNP and Humsavar for NCAM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs35654962 - 21,338,529(-) CTTAT(C/T)GCCTT nc-transcript-variant, reference, missense
rs232518 - 21,373,867(+) GAGCC(C/T)GGACG nc-transcript-variant, reference, missense
rs232372 -- 21,331,568(+) atata(C/T)atata intron-variant
rs232373 -- 21,331,619(+) atctc(A/C)ctccg intron-variant
rs232374 -- 21,341,010(+) TTACT(G/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAM2 Gene

Variant ID Type Subtype PubMed ID
esv2751925 CNV Loss 17911159
nsv821690 CNV Loss 15273396
dgv4696n71 CNV Loss 21882294
esv2723243 CNV Deletion 23290073
nsv9859 CNV Loss 18304495
nsv913500 CNV Loss 21882294
nsv913501 CNV Loss 21882294
nsv507916 CNV Insertion 20534489
esv991118 CNV Insertion 20482838
esv1743038 CNV Insertion 17803354
esv2723244 CNV Deletion 23290073
nsv913502 CNV Loss 21882294
nsv913503 CNV Loss 21882294
nsv828838 CNV Gain 20364138
nsv913504 CNV Loss 21882294
esv1111053 CNV Insertion 17803354
esv2662138 CNV Deletion 23128226
esv2657272 CNV Deletion 23128226
esv1433890 CNV Insertion 17803354
esv259744 OTHER Complex 20981092
nsv913505 CNV Loss 21882294
nsv913506 CNV Loss 21882294
nsv521484 CNV Loss 19592680
nsv913507 CNV Loss 21882294
nsv820109 CNV Gain 19587683
nsv913508 CNV Loss 21882294
dgv4697n71 CNV Loss 21882294
dgv4698n71 CNV Loss 21882294
nsv470889 CNV Gain 18288195
dgv4699n71 CNV Loss 21882294
dgv4700n71 CNV Loss 21882294
nsv817920 CNV Gain 17921354
nsv913517 CNV Gain 21882294
nsv459135 CNV Loss 19166990
nsv510497 CNV Loss 20534489
esv2462157 CNV Deletion 19546169

Variation tolerance for NCAM2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.53; 94.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NCAM2 Gene

Disorders for NCAM2 Gene

Relevant External Links for NCAM2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NCAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAM2 Gene

Publications for NCAM2 Gene

  1. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. (PMID: 9226371) Paoloni-Giacobino A. … Antonarakis S.E. (Genomics 1997) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. (PMID: 24962325) Kapoor M. … Goate A. (Drug Alcohol Depend 2014) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. Neural cell adhesion molecule 2 as a target molecule for prostate and breast cancer gene therapy. (PMID: 21214674) Takahashi S. … Hamada H. (Cancer Sci. 2011) 3

Products for NCAM2 Gene

Sources for NCAM2 Gene