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Aliases for NCAM2 Gene

Aliases for NCAM2 Gene

  • Neural Cell Adhesion Molecule 2 2 3 5
  • N-CAM-2 3 4
  • NCAM-2 3 4
  • NCAM21 3 4

External Ids for NCAM2 Gene

Previous GeneCards Identifiers for NCAM2 Gene

  • GC21P019231
  • GC21P019032
  • GC21P021292
  • GC21P022370
  • GC21P007759

Summaries for NCAM2 Gene

Entrez Gene Summary for NCAM2 Gene

  • The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCAM2 Gene

NCAM2 (Neural Cell Adhesion Molecule 2) is a Protein Coding gene. Among its related pathways are Prion diseases and Cell adhesion molecules (CAMs). An important paralog of this gene is NCAM1.

UniProtKB/Swiss-Prot for NCAM2 Gene

  • May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM2 Gene

Genomics for NCAM2 Gene

Regulatory Elements for NCAM2 Gene

Enhancers for NCAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NCAM2 on UCSC Golden Path with GeneCards custom track

Promoters for NCAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the NCAM2 gene promoter:

Genomic Location for NCAM2 Gene

Chromosome:
21
Start:
20,998,315 bp from pter
End:
21,543,329 bp from pter
Size:
545,015 bases
Orientation:
Plus strand

Genomic View for NCAM2 Gene

Genes around NCAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM2 Gene

Proteins for NCAM2 Gene

  • Protein details for NCAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15394-NCAM2_HUMAN
    Recommended name:
    Neural cell adhesion molecule 2
    Protein Accession:
    O15394
    Secondary Accessions:
    • A8MQ06
    • B7Z841
    • Q7Z7F2

    Protein attributes for NCAM2 Gene

    Size:
    837 amino acids
    Molecular mass:
    93046 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NCAM2 Gene

    Alternative splice isoforms for NCAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NCAM2 Gene

Post-translational modifications for NCAM2 Gene

  • Glycosylation at Asn 177, Asn 219, Asn 309, Asn 406, Asn 419, Asn 445, Asn 474, and Asn 562
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for NCAM2

No data available for DME Specific Peptides for NCAM2 Gene

Domains & Families for NCAM2 Gene

Graphical View of Domain Structure for InterPro Entry

O15394

UniProtKB/Swiss-Prot:

NCAM2_HUMAN :
  • Contains 2 fibronectin type-III domains.
Domain:
  • Contains 2 fibronectin type-III domains.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with NCAM2: view

Function for NCAM2 Gene

Molecular function for NCAM2 Gene

GENATLAS Biochemistry:
cell adhesion molecule,neural,2,immunoglobulin superfamily
UniProtKB/Swiss-Prot Function:
May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons.
genes like me logo Genes that share phenotypes with NCAM2: view

Animal Models for NCAM2 Gene

MGI Knock Outs for NCAM2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NCAM2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM2 Gene

Localization for NCAM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM2 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAM2 Gene COMPARTMENTS Subcellular localization image for NCAM2 gene
Compartment Confidence
plasma membrane 5
peroxisome 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with NCAM2: view

Pathways & Interactions for NCAM2 Gene

genes like me logo Genes that share pathways with NCAM2: view

Pathways by source for NCAM2 Gene

2 KEGG pathways for NCAM2 Gene

Interacting Proteins for NCAM2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000383392%0d%0a9606.ENSP00000298231%0d%0a9606.ENSP00000368752%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000404860%0d%0a
Selected Interacting proteins: ENSP00000383392 O15394-NCAM2_HUMAN for NCAM2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NCAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007158 neuron cell-cell adhesion TAS 9226371
GO:0007413 axonal fasciculation IEA --
GO:0007608 sensory perception of smell IEA --
genes like me logo Genes that share ontologies with NCAM2: view

No data available for SIGNOR curated interactions for NCAM2 Gene

Drugs & Compounds for NCAM2 Gene

No Compound Related Data Available

Transcripts for NCAM2 Gene

Unigene Clusters for NCAM2 Gene

Neural cell adhesion molecule 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM2 Gene

No ASD Table

Relevant External Links for NCAM2 Gene

GeneLoc Exon Structure for
NCAM2
ECgene alternative splicing isoforms for
NCAM2

Expression for NCAM2 Gene

mRNA expression in normal human tissues for NCAM2 Gene

mRNA differential expression in normal tissues according to GTEx for NCAM2 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x6.0), Brain - Frontal Cortex (BA9) (x5.0), Brain - Amygdala (x5.0), Brain - Hippocampus (x4.7), Brain - Hypothalamus (x4.2), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for NCAM2 Gene

This gene is overexpressed in Serum (20.2), Brain (17.7), and Frontal cortex (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NCAM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NCAM2 Gene:

NCAM2

SOURCE GeneReport for Unigene cluster for NCAM2 Gene:

Hs.473450

mRNA Expression by UniProt/SwissProt for NCAM2 Gene:

O15394-NCAM2_HUMAN
Tissue specificity: Expressed most strongly in adult and fetal brain.
genes like me logo Genes that share expression patterns with NCAM2: view

Primer Products

No data available for Protein tissue co-expression partners for NCAM2 Gene

Orthologs for NCAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCAM2 34
  • 92.56 (n)
  • 95.87 (a)
NCAM2 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAM2 34
  • 93 (n)
  • 96.48 (a)
NCAM2 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncam2 34
  • 86.85 (n)
  • 93.57 (a)
Ncam2 16
Ncam2 35
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCAM2 34
  • 99.36 (n)
  • 99.28 (a)
NCAM2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncam2 34
  • 86.08 (n)
  • 92.96 (a)
oppossum
(Monodelphis domestica)
Mammalia NCAM2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAM2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAM2 34
  • 81.72 (n)
  • 87.26 (a)
NCAM2 35
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAM2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam2 34
  • 74.62 (n)
  • 76.36 (a)
Str.11852 34
zebrafish
(Danio rerio)
Actinopterygii ncam2 34
zgc:152904 34
  • 63.14 (n)
  • 66.17 (a)
ncam2 35
  • 61 (a)
OneToMany
NCAM2 (2 of 2) 35
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Fas2 36
  • 29 (a)
CG15630 35
  • 22 (a)
ManyToMany
CG33543 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ncam-1 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for NCAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM2 Gene

ENSEMBL:
Gene Tree for NCAM2 (if available)
TreeFam:
Gene Tree for NCAM2 (if available)

Paralogs for NCAM2 Gene

Paralogs for NCAM2 Gene

(4) SIMAP similar genes for NCAM2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NCAM2: view

Variants for NCAM2 Gene

Sequence variations from dbSNP and Humsavar for NCAM2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs35654962 - 21,338,529(-) CTTAT(C/T)GCCTT nc-transcript-variant, reference, missense
rs232518 - 21,373,867(+) GAGCC(C/T)GGACG nc-transcript-variant, reference, missense
rs232372 -- 21,331,568(+) atata(C/T)atata intron-variant
rs232373 -- 21,331,619(+) atctc(A/C)ctccg intron-variant
rs232374 -- 21,341,010(+) TTACT(G/T)TTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAM2 Gene

Variant ID Type Subtype PubMed ID
dgv2366n106 CNV tandem duplication 24896259
dgv4402n100 CNV gain 25217958
dgv4403n100 CNV loss 25217958
dgv7788n54 CNV loss 21841781
dgv803e214 CNV loss 21293372
esv1111053 CNV insertion 17803354
esv1433890 CNV insertion 17803354
esv1743038 CNV insertion 17803354
esv2462157 CNV deletion 19546169
esv2657272 CNV deletion 23128226
esv2662138 CNV deletion 23128226
esv2723243 CNV deletion 23290073
esv2723244 CNV deletion 23290073
esv2751925 CNV loss 17911159
esv3302770 CNV tandem duplication 20981092
esv3344210 CNV duplication 20981092
esv3568127 CNV loss 25503493
esv3646564 CNV gain 21293372
esv3646569 CNV loss 21293372
esv3646571 CNV loss 21293372
esv3646572 CNV loss 21293372
esv3646574 CNV loss 21293372
esv3646575 CNV loss 21293372
esv991118 CNV insertion 20482838
nsv1057445 CNV loss 25217958
nsv1057774 CNV gain 25217958
nsv1060947 CNV loss 25217958
nsv1062692 CNV loss 25217958
nsv1072594 CNV deletion 25765185
nsv1114270 CNV deletion 24896259
nsv1123541 CNV deletion 24896259
nsv1125742 CNV tandem duplication 24896259
nsv1127882 CNV deletion 24896259
nsv1127883 CNV deletion 24896259
nsv1136609 CNV deletion 24896259
nsv1136610 CNV deletion 24896259
nsv1143015 CNV tandem duplication 24896259
nsv459135 CNV loss 19166990
nsv470889 CNV gain 18288195
nsv474227 CNV novel sequence insertion 20440878
nsv478325 CNV novel sequence insertion 20440878
nsv479480 CNV novel sequence insertion 20440878
nsv507916 OTHER sequence alteration 20534489
nsv510497 OTHER sequence alteration 20534489
nsv521484 CNV loss 19592680
nsv587210 CNV loss 21841781
nsv587211 CNV loss 21841781
nsv587212 CNV loss 21841781
nsv587213 CNV loss 21841781
nsv587214 CNV loss 21841781
nsv587217 CNV loss 21841781
nsv817920 CNV gain 17921354
nsv820109 CNV gain 19587683
nsv821690 CNV loss 15273396
nsv828838 CNV gain 20364138
nsv956772 CNV insertion 24416366
nsv9859 CNV loss 18304495

Variation tolerance for NCAM2 Gene

Residual Variation Intolerance Score: 20% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.53; 94.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM2 Gene

Disorders for NCAM2 Gene

Relevant External Links for NCAM2

Genetic Association Database (GAD)
NCAM2
Human Genome Epidemiology (HuGE) Navigator
NCAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAM2

No disorders were found for NCAM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAM2 Gene

Publications for NCAM2 Gene

  1. Cloning of a novel human neural cell adhesion molecule gene (NCAM2) that maps to chromosome region 21q21 and is potentially involved in Down syndrome. (PMID: 9226371) Paoloni-Giacobino A. … Antonarakis S.E. (Genomics 1997) 2 3 4 65
  2. A genome-wide association study on obesity and obesity-related traits. (PMID: 21552555) Wang K. … Price R.A. (PLoS ONE 2011) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. Joint influence of small-effect genetic variants on human longevity. (PMID: 20834067) Yashin A.I. … Ukraintseva S.V. (Aging (Albany NY) 2010) 3 46 65
  5. Genome-wide association reveals genetic effects on human AI^42 and I8 protein levels in cerebrospinal fluids: a case control study. (PMID: 20932310) Han M.R. … Wang L.S. (BMC Neurol 2010) 3 46 65

Products for NCAM2 Gene

Sources for NCAM2 Gene

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