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Aliases for NCAM1 Gene

Aliases for NCAM1 Gene

  • Neural Cell Adhesion Molecule 1 2 3
  • MSK39 3 6
  • NCAM 3 4
  • Antigen Recognized By Monoclonal Antibody 5.1H11 3
  • Neural Cell Adhesion Molecule, NCAM 3
  • CD56 Antigen 4
  • N-CAM-1 4
  • NCAM-1 4
  • CD56 3

External Ids for NCAM1 Gene

Previous GeneCards Identifiers for NCAM1 Gene

  • GC11P115185
  • GC11P114344
  • GC11P112866
  • GC11P112369
  • GC11P112337
  • GC11P112831
  • GC11P108759

Summaries for NCAM1 Gene

Entrez Gene Summary for NCAM1 Gene

  • This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

GeneCards Summary for NCAM1 Gene

NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include transitional meningioma and gastric small cell carcinoma. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include identical protein binding. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot for NCAM1 Gene

  • This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc

Tocris Summary for NCAM1 Gene

Gene Wiki entry for NCAM1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM1 Gene

Genomics for NCAM1 Gene

Regulatory Elements for NCAM1 Gene

Transcription factor binding sites by QIAGEN in the NCAM1 gene promoter:

Genomic Location for NCAM1 Gene

112,961,247 bp from pter
113,278,436 bp from pter
317,190 bases
Plus strand

Genomic View for NCAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM1 Gene

Proteins for NCAM1 Gene

  • Protein details for NCAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neural cell adhesion molecule 1
    Protein Accession:
    Secondary Accessions:
    • A8K8T8
    • P13592
    • P13593
    • Q05C58
    • Q15829
    • Q16180
    • Q16209
    • Q59FL7
    • Q86X47
    • Q96CJ3

    Protein attributes for NCAM1 Gene

    858 amino acids
    Molecular mass:
    94574 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92680.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCAM1 Gene

    Alternative splice isoforms for NCAM1 Gene

neXtProt entry for NCAM1 Gene

Proteomics data for NCAM1 Gene at MOPED

Post-translational modifications for NCAM1 Gene

  • Glycosylation at Thr125, Asn222, Asn315, Asn347, Asn423, Asn449, and Asn478
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NCAM1 Gene

Domains for NCAM1 Gene

Suggested Antigen Peptide Sequences for NCAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 fibronectin type-III domains.
  • Contains 2 fibronectin type-III domains.
  • Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with NCAM1: view

Function for NCAM1 Gene

Molecular function for NCAM1 Gene

GENATLAS Biochemistry:
cell adhesion molecule,neural,1,immunoglobulin superfamily
UniProtKB/Swiss-Prot Function:
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc

Gene Ontology (GO) - Molecular Function for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IPI 21115007
genes like me logo Genes that share ontologies with NCAM1: view
genes like me logo Genes that share phenotypes with NCAM1: view

Animal Models for NCAM1 Gene

MGI Knock Outs for NCAM1:

Animal Model Products

CRISPR Products

miRNA for NCAM1 Gene

miRTarBase miRNAs that target NCAM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NCAM1 Gene

Localization for NCAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 4: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 5: Secreted.
Isoform 6: Secreted.

Subcellular locations from

Jensen Localization Image for NCAM1 Gene COMPARTMENTS Subcellular localization image for NCAM1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
golgi apparatus 4
cytoskeleton 3
nucleus 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction --
GO:0009897 external side of plasma membrane IDA 17213291
genes like me logo Genes that share ontologies with NCAM1: view

Pathways for NCAM1 Gene

genes like me logo Genes that share pathways with NCAM1: view

Pathways by source for NCAM1 Gene

1 Sino Biological pathway for NCAM1 Gene
3 Cell Signaling Technology pathways for NCAM1 Gene
2 KEGG pathways for NCAM1 Gene
1 GeneGo (Thomson Reuters) pathway for NCAM1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001928 regulation of exocyst assembly --
GO:0007155 cell adhesion IEA --
GO:0007166 cell surface receptor signaling pathway --
GO:0007411 axon guidance TAS --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with NCAM1: view

Drugs for NCAM1 Gene

(5) Tocris Compounds for NCAM1 Gene

Compound Action Cas Number
A 286982 Potent inhibitor of the LFA-1/ICAM-1 interaction [280749-17-9]
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation [151988-33-9]
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor [154303-05-6]
Heparin sodium salt Anticoagulant [9041-08-1]
RGDS peptide Integrin binding sequence; inhibits integrin receptor function [91037-65-9]

(57) Novoseek inferred chemical compound relationships for NCAM1 Gene

Compound -log(P) Hits PubMed IDs
nkh 1 75.8 1
fuc-gm1 64.6 1
sialic acid 53.4 25
neurocan 49.9 12
smcc 38.1 2
genes like me logo Genes that share compounds with NCAM1: view

Transcripts for NCAM1 Gene

Unigene Clusters for NCAM1 Gene

Neural cell adhesion molecule 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAM1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: - - - - -
SP2: - -

Relevant External Links for NCAM1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NCAM1 Gene

mRNA expression in normal human tissues for NCAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NCAM1 Gene

This gene is overexpressed in Fetal Brain (17.6), Frontal cortex (11.4), Retina (11.0), and Brain (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAM1 Gene

SOURCE GeneReport for Unigene cluster for NCAM1 Gene Hs.503878

genes like me logo Genes that share expressions with NCAM1: view

Expression partners for NCAM1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NCAM1 Gene

Orthologs for NCAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NCAM1 35
  • 91.72 (n)
  • 96.71 (a)
NCAM1 36
  • 94 (a)
(Canis familiaris)
Mammalia NCAM1 35
  • 92.42 (n)
  • 97 (a)
NCAM1 36
  • 73 (a)
(Mus musculus)
Mammalia Ncam1 35
  • 89.27 (n)
  • 94.81 (a)
Ncam1 16
Ncam1 36
  • 95 (a)
(Pan troglodytes)
Mammalia NCAM1 35
  • 99.51 (n)
  • 99.55 (a)
NCAM1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ncam1 35
  • 89.19 (n)
  • 95.1 (a)
(Monodelphis domestica)
Mammalia NCAM1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
-- 36
  • 80 (a)
(Gallus gallus)
Aves NCAM1 35
  • 81.84 (n)
  • 88.09 (a)
NCAM1 36
  • 66 (a)
(Anolis carolinensis)
Reptilia NCAM1 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam1 35
  • 70.66 (n)
  • 74.49 (a)
African clawed frog
(Xenopus laevis)
Amphibia NCAM 35
(Danio rerio)
Actinopterygii -- 35
ncam1a 35
  • 68.35 (n)
  • 65.59 (a)
ncam1a 36
  • 65 (a)
ncam1b 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fas2 37
  • 26 (a)
Fas2 35
  • 43.13 (n)
  • 28.19 (a)
CG15630 36
  • 21 (a)
CG33543 36
  • 21 (a)
Fas2 36
  • 24 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002802 35
  • 44.49 (n)
  • 30.81 (a)
(Caenorhabditis elegans)
Secernentea ncam-1 35
  • 41.33 (n)
  • 28.19 (a)
ncam-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for NCAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM1 Gene

Gene Tree for NCAM1 (if available)
Gene Tree for NCAM1 (if available)

Paralogs for NCAM1 Gene

Paralogs for NCAM1 Gene

(5) SIMAP similar genes for NCAM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NCAM1: view

Variants for NCAM1 Gene

Sequence variations from dbSNP and Humsavar for NCAM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1061 -- 113,118,576(+) TTTAT(C/T)GTCTG intron-variant
rs1884 -- 113,009,875(-) TTATT(C/G)CCTTC intron-variant
rs9289 -- 113,278,379(+) GAATT(A/T)TGACT utr-variant-3-prime
rs582463 -- 113,248,055(+) TTCGG(A/G)ACGAA intron-variant
rs584427 -- 113,233,274(-) TCACC(A/C)ACTGC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for NCAM1 Gene

Variant ID Type Subtype PubMed ID
nsv832271 CNV Gain 17160897
nsv526604 CNV Loss 19592680
nsv468870 CNV Loss 19166990
nsv832272 CNV Gain 17160897
esv2745085 CNV Deletion 23290073
esv2664094 CNV Deletion 23128226
esv24924 CNV Loss 19812545
nsv516224 CNV Loss 19592680
nsv515828 CNV Loss 19592680

Relevant External Links for NCAM1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM1 Gene

Disorders for NCAM1 Gene

(92) Novoseek inferred disease relationships for NCAM1 Gene

Disease -log(P) Hits PubMed IDs
small cell lung cancer 65.1 27
carcinoma neuroendocrine 58.5 3
peripheral neuroepithelioma 49.6 1
neuroendocrine tumors 49.2 8
carcinoma merkel cell 49.1 5

Relevant External Links for NCAM1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NCAM1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for NCAM1 Gene

Publications for NCAM1 Gene

  1. Splicing of the VASE exon of neural cell adhesion molecule (NCAM) in human small-cell lung carcinoma (SCLC). (PMID: 1339414) van Duijnhoven H.L. … Patel K. (Int. J. Cancer 1992) 3 4 23
  2. Molecular and functional analysis of human natural killer cell- associated neural cell adhesion molecule (N-CAM/CD56). (PMID: 1710251) Lanier L.L. … Phillips J.H. (J. Immunol. 1991) 3 4 23
  3. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  4. Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. (PMID: 21212386) Arnett D.K. … Kardia S.L. (Circ. Res. 2011) 3 48
  5. The expression pattern of CD56 (N-CAM) in human bone marrow biopsies infiltrated by acute leukemia. (PMID: 14959847) Khanlari B. … Dirnhofer S. (Leuk. Lymphoma 2003) 3 23

Products for NCAM1 Gene

Sources for NCAM1 Gene

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