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Aliases for NCAM1 Gene

Aliases for NCAM1 Gene

  • Neural Cell Adhesion Molecule 1 2 3 5
  • NCAM 3 4
  • Antigen Recognized By Monoclonal Antibody 5.1H11 3
  • Neural Cell Adhesion Molecule, NCAM 3
  • CD56 Antigen 4
  • N-CAM-1 4
  • NCAM-1 4
  • MSK39 3
  • CD56 3

External Ids for NCAM1 Gene

Previous GeneCards Identifiers for NCAM1 Gene

  • GC11P115185
  • GC11P114344
  • GC11P112866
  • GC11P112369
  • GC11P112337
  • GC11P112831
  • GC11P108759

Summaries for NCAM1 Gene

Entrez Gene Summary for NCAM1 Gene

  • This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]

GeneCards Summary for NCAM1 Gene

NCAM1 (Neural Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NCAM1 include Plasma Cell Leukemia and Rabies. Among its related pathways are RET signaling and Interferon gamma signaling. GO annotations related to this gene include identical protein binding. An important paralog of this gene is NCAM2.

UniProtKB/Swiss-Prot for NCAM1 Gene

  • This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.

  • (Microbial infection) Acts as a receptor for rabies virus.

Tocris Summary for NCAM1 Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for NCAM1 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAM1 Gene

Genomics for NCAM1 Gene

Regulatory Elements for NCAM1 Gene

Enhancers for NCAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G112960 1.6 FANTOM5 ENCODE dbSUPER 17.1 +1.4 1428 3.8 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 GLIS2 KLF7 ZNF263 SP3 YY2 NCAM1 LOC105369499 NCAM1-AS1 LOC101928847
GH11G112881 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.8 -78.7 -78725 3.0 MXI1 PKNOX1 ZFHX2 POLR2A NFYB SP2 REST EGR2 NCAM1 LOC101928847 RNU7-187P PIR45615 LOC105369498
GH11G113187 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +229.8 229812 7.1 PKNOX1 ATF1 CREB3L1 ZSCAN4 FEZF1 CREM CEBPB NR2F2 CREB3 SMARCA4 NCAM1-AS1 NCAM1 GC11P112980
GH11G112756 1 ENCODE dbSUPER 17.8 -203.6 -203629 1.3 ARID3A CBX5 POLR2A EED ETV6 RELB IKZF2 CREM MTA2 CBFB NCAM1 LOC105369496 ENSG00000254626
GH11G113183 1.6 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +223.3 223328 1.4 TFAP4 TFE3 JUN MAX USF2 CEBPB CEBPG EP300 RFX5 JUND NCAM1-AS1 NCAM1 GC11P112980
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NCAM1 on UCSC Golden Path with GeneCards custom track

Promoters for NCAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045075 453 1000 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 GLIS2 KLF7 ZNF263 SP3 YY2
ENSR00000045076 1854 1000 ZSCAN4 SIN3A ZNF76 KLF17 FEZF1 GLIS2 EGR2 ZNF263 SP3 OVOL3

Transcription factor binding sites by QIAGEN in the NCAM1 gene promoter:

Genomic Location for NCAM1 Gene

Chromosome:
11
Start:
112,961,247 bp from pter
End:
113,278,436 bp from pter
Size:
317,190 bases
Orientation:
Plus strand

Genomic View for NCAM1 Gene

Genes around NCAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAM1 Gene

Proteins for NCAM1 Gene

  • Protein details for NCAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13591-NCAM1_HUMAN
    Recommended name:
    Neural cell adhesion molecule 1
    Protein Accession:
    P13591
    Secondary Accessions:
    • A8K8T8
    • P13592
    • P13593
    • Q05C58
    • Q15829
    • Q16180
    • Q16209
    • Q59FL7
    • Q86X47
    • Q96CJ3

    Protein attributes for NCAM1 Gene

    Size:
    858 amino acids
    Molecular mass:
    94574 Da
    Quaternary structure:
    • (Microbial infection) Interacts with rabies virus glycoprotein.
    SequenceCaution:
    • Sequence=BAD92680.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NCAM1 Gene

    Alternative splice isoforms for NCAM1 Gene

neXtProt entry for NCAM1 Gene

Post-translational modifications for NCAM1 Gene

  • Glycosylation at posLast=125125, Asn222, posLast=315315, Asn347, posLast=423423, Asn449, and posLast=478478
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NCAM1 Gene

Domains & Families for NCAM1 Gene

Suggested Antigen Peptide Sequences for NCAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NCAM1: view

No data available for UniProtKB/Swiss-Prot for NCAM1 Gene

Function for NCAM1 Gene

Molecular function for NCAM1 Gene

GENATLAS Biochemistry:
cell adhesion molecule,neural,1,immunoglobulin superfamily
UniProtKB/Swiss-Prot Function:
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for rabies virus.

Gene Ontology (GO) - Molecular Function for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with NCAM1: view
genes like me logo Genes that share phenotypes with NCAM1: view

Animal Models for NCAM1 Gene

MGI Knock Outs for NCAM1:

Animal Model Products

CRISPR Products

miRNA for NCAM1 Gene

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCAM1 Gene

Localization for NCAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Cell membrane; Single-pass type I membrane protein.
Isoform 3: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 4: Cell membrane; Lipid-anchor, GPI-anchor.
Isoform 5: Secreted.
Isoform 6: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NCAM1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 5
golgi apparatus 4
cytoskeleton 3
nucleus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,TAS --
GO:0009897 external side of plasma membrane IDA 17213291
genes like me logo Genes that share ontologies with NCAM1: view

Pathways & Interactions for NCAM1 Gene

SuperPathways for NCAM1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Innate Immune System
5 Interferon gamma signaling
genes like me logo Genes that share pathways with NCAM1: view

Gene Ontology (GO) - Biological Process for NCAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance TAS --
GO:0016032 viral process IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with NCAM1: view

No data available for SIGNOR curated interactions for NCAM1 Gene

Drugs & Compounds for NCAM1 Gene

(33) Drugs for NCAM1 Gene - From: ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Thiolutin Pharma RNA polymerase inhibitor,antibiotic 0
LORVOTUZUMAB Pharma 0
BIO 5192 Pharma Integrin α4β1 inhibitor, Highly potent and selective inhibitor of integrin alpha4beta1 0
RGDS peptide Pharma Integrin binding sequence; inhibits integrin receptor function 0

(31) Additional Compounds for NCAM1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-26
151988-33-9
Echistatin, alpha1 isoform
154303-05-6
Heparin sodium salt
9041-08-1

(5) Tocris Compounds for NCAM1 Gene

Compound Action Cas Number
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 327613-57-0
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
Heparin sodium salt Anticoagulant 9041-08-1
RGDS peptide Integrin binding sequence; inhibits integrin receptor function 91037-65-9

(1) ApexBio Compounds for NCAM1 Gene

Compound Action Cas Number
Thiolutin RNA polymerase inhibitor,antibiotic 1987-11-6
genes like me logo Genes that share compounds with NCAM1: view

Transcripts for NCAM1 Gene

Unigene Clusters for NCAM1 Gene

Neural cell adhesion molecule 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCAM1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20
SP1: - - - - -
SP2: - -
SP3:
SP4:
SP5:

Relevant External Links for NCAM1 Gene

GeneLoc Exon Structure for
NCAM1
ECgene alternative splicing isoforms for
NCAM1

Expression for NCAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NCAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NCAM1 Gene

This gene is overexpressed in Fetal Brain (17.6), Frontal cortex (11.4), Retina (11.0), and Brain (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NCAM1 Gene



Protein tissue co-expression partners for NCAM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NCAM1 Gene:

NCAM1

SOURCE GeneReport for Unigene cluster for NCAM1 Gene:

Hs.503878

Evidence on tissue expression from TISSUES for NCAM1 Gene

  • Nervous system(5)
  • Bone marrow(4.6)
  • Muscle(4.6)
  • Liver(4.5)
  • Kidney(4.4)
  • Blood(3.7)
  • Eye(2.8)
  • Heart(2.8)
  • Lung(2.8)
  • Lymph node(2.7)
  • Spleen(2.7)
  • Adrenal gland(2.6)
  • Thyroid gland(2.5)
  • Intestine(2.4)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with NCAM1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NCAM1 Gene

Orthologs for NCAM1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NCAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAM1 35 34
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NCAM1 35 34
  • 92.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NCAM1 35 34
  • 91.72 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ncam1 35 16 34
  • 89.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncam1 34
  • 89.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NCAM1 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAM1 35 34
  • 81.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAM1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncam1 34
  • 70.66 (n)
African clawed frog
(Xenopus laevis)
Amphibia NCAM 34
zebrafish
(Danio rerio)
Actinopterygii ncam1a 35 34
  • 68.35 (n)
OneToMany
ncam1b 35
  • 49 (a)
OneToMany
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002802 34
  • 44.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fas2 36 34 35
  • 43.13 (n)
CG15630 35
  • 21 (a)
ManyToMany
CG33543 35
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ncam-1 35 34
  • 41.33 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
OneToMany
Species where no ortholog for NCAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCAM1 Gene

ENSEMBL:
Gene Tree for NCAM1 (if available)
TreeFam:
Gene Tree for NCAM1 (if available)

Paralogs for NCAM1 Gene

Paralogs for NCAM1 Gene

(5) SIMAP similar genes for NCAM1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NCAM1: view

Variants for NCAM1 Gene

Sequence variations from dbSNP and Humsavar for NCAM1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000001757 -- 113,182,613(+) GGGAG(C/T)AGCTG intron-variant
rs1000017383 -- 113,270,147(+) TCGCA(A/T)CTCAG intron-variant
rs1000063052 -- 113,012,056(+) CTCCG(C/T)CTCCC intron-variant
rs1000087888 -- 113,194,179(+) TAGAG(G/T)TGCGT intron-variant
rs1000090738 -- 113,263,846(+) GAGAA(A/G)GAGAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NCAM1 Gene

Variant ID Type Subtype PubMed ID
dgv1279n100 CNV loss 25217958
esv24924 CNV loss 19812545
esv2664094 CNV deletion 23128226
esv2745085 CNV deletion 23290073
esv3548358 CNV deletion 23714750
esv3627771 CNV loss 21293372
esv3627772 CNV loss 21293372
esv3627773 CNV gain 21293372
esv3627774 CNV loss 21293372
esv3627775 CNV loss 21293372
nsv1038796 CNV gain 25217958
nsv468870 CNV loss 19166990
nsv483080 CNV loss 15286789
nsv515828 CNV loss 19592680
nsv516224 CNV loss 19592680
nsv526604 CNV loss 19592680
nsv556442 CNV loss 21841781
nsv556443 CNV loss 21841781
nsv832271 CNV gain 17160897
nsv832272 CNV gain 17160897
nsv951071 CNV duplication 24416366

Variation tolerance for NCAM1 Gene

Gene Damage Index Score: 7.28; 81.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCAM1 Gene

Human Gene Mutation Database (HGMD)
NCAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NCAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAM1 Gene

Disorders for NCAM1 Gene

MalaCards: The human disease database

(91) MalaCards diseases for NCAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
plasma cell leukemia
  • leukemia, plasma cell
rabies
  • lyssa
hypoganglionosis
  • intestinal hypoganglionosis
orbit lymphoma
  • lymphoma of the orbit
ovarian serous adenofibroma
- elite association - COSMIC cancer census association via MalaCards
Search NCAM1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NCAM1

Genetic Association Database (GAD)
NCAM1
Human Genome Epidemiology (HuGE) Navigator
NCAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAM1
genes like me logo Genes that share disorders with NCAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NCAM1 Gene

Publications for NCAM1 Gene

  1. Molecular and functional analysis of human natural killer cell- associated neural cell adhesion molecule (N-CAM/CD56). (PMID: 1710251) Lanier L.L. … Phillips J.H. (J. Immunol. 1991) 3 4 22 64
  2. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 46 64
  3. Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. (PMID: 21212386) Arnett D.K. … Kardia S.L. (Circ. Res. 2011) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for NCAM1 Gene

Sources for NCAM1 Gene

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