External Ids for NCALD Gene
Previous GeneCards Identifiers for NCALD Gene
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for NCALD Gene
NCALD (Neurocalcin Delta) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Transmission across Chemical Synapses. GO annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is HPCAL1.
UniProtKB/Swiss-Prot for NCALD Gene
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.