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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCALD Gene

protein-coding   GIFtS: 62
GCID: GC08M102767

neurocalcin delta
 Explore 9 diseases affiliated with
NCALD via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NCALD    

Aliases
for NCALD gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neurocalcin Delta1 2
Neurocalcin-Delta1

External Ids:    HGNC: 76551   Entrez Gene: 839882   Ensembl: ENSG000001044907   OMIM: 6067225   UniProtKB: P616013   

Export aliases for NCALD gene to outside databases

Previous GC identifers: GC08M101704 GC08M102766 GC08M102367 GC08M102655 GC08M097897


Summaries
for NCALD gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NCALD:
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein
contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at
resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the
myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear
trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction.
Several alternatively spliced variants of this gene have been determined, all of which encode the same protein;
additional variants may exist but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions




Genomic Views
for NCALD gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCALD gene promoter:
         AML1a   HOXA3   ATF-2   FOXO3   FOXO3a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NCALD promoter sequence
   Search SABiosciences Chromatin IP Primers for NCALD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCALD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22-q23

NCALD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCALD gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M102767:  view genomic region     (about GC identifiers)

Start:
 102,698,770 bp from pter      End:
 103,137,135 bp from pter
Size:
 438,366 bases      Orientation:
 minus strand

Proteins
for NCALD gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601 (See protein sequence)
Recommended Name: Neurocalcin-delta  
Size: 193 amino acids; 22245 Da
Secondary accessions: P29554 Q8IYC3 Q9H0W2

Explore the universe of human proteins at neXtProt for NCALD: NX_P61601

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61601

    • NCALD Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_001035714.1  NP_001035715.1  NP_001035716.1  NP_001035717.1  NP_001035718.1  NP_001035719.1  NP_001035720.1  NP_114430.2  

    ENSEMBL proteins: 
     ENSP00000220931   ENSP00000428105   ENSP00000430476   ENSP00000428781   ENSP00000429466  
     ENSP00000429255   ENSP00000430731   ENSP00000430925   ENSP00000429522   ENSP00000428598  
     ENSP00000428312   ENSP00000429493   ENSP00000429245   ENSP00000430064   ENSP00000430534  
     ENSP00000428193   ENSP00000430365   ENSP00000428093   ENSP00000429296   ENSP00000430578  
     ENSP00000429162   ENSP00000429347   ENSP00000379256   ENSP00000310587  
    Reactome Protein details: P61601
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: NCALD
    OriGene Protein Over-expression Lysate (see all 15): NCALD
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    Novus Biologicals NCALD Proteins
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    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NCALD
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005829cytosol TAS--
    GO:0030130clathrin coat of trans-Golgi network vesicle NAS11964161


    NCALD for ontologies           About GeneDecksing



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    ThermoFisher Antibodies for NCALD

    Assay Products for NCALD: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for NCALD gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NCALD for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR018247 EF_Hand_1_Ca_BS
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018248 EF-hand

    Graphical View of Domain Structure for InterPro Entry P61601

    ProtoNet protein and cluster: P61601

    1 Blocks protein family: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    Function
    for NCALD gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
    Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 8): NCALD
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCALD
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NCALD (see all 49):
    hsa-miR-21* hsa-miR-513a-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-4314 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: NCALD 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCALD (see all 7)
    OriGene shRNA RFP: NCALD
    OriGene siRNA: NCALD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCALD

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NCALD

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCALD (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 8): NCALD (NM_001040628)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCALD 

    Cell Line
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    Search LifeMap BioReagents cell lines for NCALD

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA11964161
    GO:0005509calcium ion binding IEA--
    GO:0015631tubulin binding IDA11964161
    GO:0030276clathrin binding IDA11964161
    GO:0043014alpha-tubulin binding IEA--


    NCALD for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NCALD:
     Increased cell number in S and 


    Pathways & Interactions
    for NCALD gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transmission across Chemical Synapses
    		Transmission across Chemical Synapses1.00
    		Neuronal System0.67
    		Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2G beta:gamma signalling through PLC beta
    		Activation of Kainate Receptors upon glutamate binding0.67
    		Ionotropic activity of Kainate Receptors0.00
    		Activation of Ca-permeable Kainate Receptor0.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for NCALD (see all 6)
        Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses
    Activation of Ca-permeable Kainate Receptor
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell



    NCALD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCALD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/68 Interacting proteins for NCALD (P616012, 3 ENSP000002209314) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202062 I2D: score=1 STRING: ENSP00000250416
    DTX2Q86UW92, 3, ENSP000003228854MINT-67559 I2D: score=5 STRING: ENSP00000322885
    ACTBP607093, ENSP000003499604I2D: score=4 STRING: ENSP00000349960
    CLTCQ006103, ENSP000002691224I2D: score=3 STRING: ENSP00000269122
    PNPP004913, ENSP000003545324I2D: score=2 STRING: ENSP00000354532
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0016192vesicle-mediated transport NAS11964161


    NCALD for ontologies           About GeneDecksing



    Drugs & Compounds
    for NCALD gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NCALD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCALD

    1 HMDB Compound for NCALD    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for NCALD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 5.71 3 11860183 (1), 11836243 (1), 17064702 (1), 18989702 (1)

    Search CenterWatch for drugs/clinical trials and news about NCALD 

    Transcripts
    for NCALD gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NCALD gene (8 alternative transcripts): 
    NM_001040624.1  NM_001040625.1  NM_001040626.1  NM_001040627.1  NM_001040628.1  NM_001040629.1  NM_001040630.1  NM_032041.2  

    Unigene Cluster for NCALD:

    Neurocalcin delta
    Hs.492427  [show with all ESTs]
    Unigene Representative Sequence: NM_001040630
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000220931 ENST00000521599 ENST00000519508 ENST00000522951 ENST00000522754
    ENST00000522448 ENST00000520690 ENST00000518727 ENST00000520425 ENST00000518166
    ENST00000522252 ENST00000517822 ENST00000524209 ENST00000517531 ENST00000521964
    ENST00000519098 ENST00000523923 ENST00000520346

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 8): NCALD
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCALD
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NCALD (see all 49):
    hsa-miR-21* hsa-miR-513a-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-4314 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmid: NCALD 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCALD (see all 7)
    OriGene shRNA RFP: NCALD
    OriGene siRNA: NCALD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCALD
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCALD (see all 13)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCALD (see all 8)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 8): NCALD (NM_001040628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCALD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCALD 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCALD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCALD

    Additional cDNA sequence: 

    AF052142.1 AF251061.1 AK055073.1 AK096515.1 AK314523.1 AL136612.1 BC009949.2 BC033319.1 
    BC036098.1 BC063428.1 

    24/27 DOTS entries (see all 27):

    DT.97776704  DT.95074105  DT.40284869  DT.95152300  DT.100794937  DT.95078929  DT.120647463  DT.95074116 
    DT.95107420  DT.100794935  DT.120647425  DT.120647410  DT.99942060  DT.120647420  DT.120647422  DT.120647449 
    DT.120647456  DT.120647478  DT.120647520  DT.92065407  DT.120647421  DT.120647429  DT.120647440  DT.120647472 

    24/199 AceView cDNA sequences (see all 199):

    BM683082 AA706200 AV708382 BP346768 H18390 AW203994 BM449845 T09286 
    BX460814 BC009949 BX477769 AK096515 AI961653 CD722496 BE858130 CK823095 
    BM719121 T33765 N48605 BX386910 AI017000 AI566944 BC033319 T33307 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for NCALD (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^
    SP1:                                                  -     -     -                                                                                             
    SP2:                                -                 -     -     -     -     -     -     -     -           -     -     -     -     -     -     -     -     -   
    SP3:                                                  -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -     -   
    SP4:                                                  -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -         
    SP5:                                -     -           -     -     -     -     -     -     -     -           -     -     -     -     -     -     -     -     -   

    ExUns: 21a · 21b ^ 22a · 22b · 22c · 22d · 22e · 22f ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26
    SP1:                                                                                    
    SP2:              -                                   -                                 
    SP3:              -                                   -                                 
    SP4:                                                                                    
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for NCALD

    Expression
    for NCALD gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCALD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTCAAGGTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NCALD expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See NCALD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCALD

    SOURCE GeneReport for Unigene cluster: Hs.492427

    UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
    Tissue specificity: Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine

        SABiosciences Custom PCR Arrays for NCALD
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCALD
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD

    Orthologs
    for NCALD gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NCALD gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NCALD1 neurocalcin delta 86.36(n)
    99.48(a)    		   396048  NM_205143.1  NP_990474.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NCALD6
    		 --
    		 100(a)
    		 1 ↔ 1
    		 4(14226135-14235514)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC054982.12   -- 84.26(n)    BC054982.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ncalda1 neurocalcin delta a 81.35(n)
    97.93(a)    		   556178  NM_001114410.1  NP_001107882.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Nca3 negative regulation of phosphorylation
    calcium ion binding less    		 87(a)
    (best of 2)    		   3 76D8   --


    ENSEMBL Gene Tree for NCALD (if available)
    TreeFam Gene Tree for NCALD (if available) 

    Paralogs
    for NCALD gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCALD gene
    HPCA2  KCNIP32  KCNIP42  GUCA1A2  KCNIP12  RCVRN2  HPCAL12  GUCA1B2  
    KCNIP22  HPCAL42  NCS12  VSNL12  GUCA1C2  
    18/23 SIMAP similar genes for NCALD using alignment to 18 protein entries:     NCALD_HUMAN (see all proteins) (see all similar genes):
    DKFZp781K1922    HPCAL1    VSNL1    HPCA    HPCAL4    NCS1
    RCV1    RCVRN    KCNIP4    KCNIP3    GUCA1A    KCNIP2
    GUCA1B    KCNIP1    DKFZp686E1183    CALM3    CALM1    PPP3R2

    NCALD for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NCALD
    PGOHUM00000257195 PGOHUM00000257196


    Genomic Variants
    for NCALD gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7556 NCBI SNPs in NCALD are shown (see all 7556)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs168681981,2
    		C,F,H,--102698284(+) CTACAG/TTAACG 8 -- ds500129Minor allele frequency- T:0.40NA NS EA WA CSA 2918
    rs1129809581,2
    		--102698454(+) TCCCAC/TTGAAG 8 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1179371351,2
    		F,--102698488(+) TTTATT/GGTACC 8 -- ds50011Minor allele frequency- G:0.07EA 120
    rs1420753891,2
    		--102698570(+) AAGGAA/GGCCCA 8 -- ds50010--------
    rs1507402091,2
    		--102698593(+) GGATGA/CCTTTG 8 -- ds50010--------
    rs1894090771,2
    		--102698621(+) AGCAGC/GCTCTC 8 -- ds50010--------
    rs1927696601,2
    		--102698624(+) AGCCTC/TTCTCA 8 -- ds50010--------
    rs1848003741,2
    		--102698657(+) CCTTGG/TGTCAC 8 -- ds50010--------
    rs1894547391,2
    		--102698787(+) AAAAAC/TATGCT 8 -- ut310--------
    rs1816494641,2
    		--102698804(+) CCAGGC/GAAGAG 8 -- ut310--------

    HapMap Linkage Disequilibrium report for NCALD (102698770 - 102948770 bp, first 250kb of NCALD)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for NCALD
         12 CNVs: 52324 10265 95607 52325 95608 65213 95609 95606 33050 1799 82713 100439
         1 Indel: 82714
    Human Gene Mutation Database (HGMD): NCALD

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    Disorders / Diseases
    for NCALD gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NCALD for disorders           About GeneDecksing

    OMIM gene information: 606722    OMIM disorders: --

    9 diseases for NCALD:    About MalaCards
    alcoholic liver cirrhosis    alcohol abuse    liver cirrhosis    pancreatic endocrine tumors
    neuronitis    alcoholism    nephropathy    pancreatitis
    retinitis

    1 disease from the University of Copenhagen DISEASES database for NCALD:
    Alcoholic liver cirrhosis
    Human Genome Epidemiology (HuGE) Navigator: NCALD (2 documents)

    Export disorders for NCALD gene to outside databases

    Publications
    for NCALD gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCALD gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with NCALD)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD). (PubMed id 11267673)1, 2, 3, 9 Wang W.... Mao Y. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    4. Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. (PubMed id 17671797)1, 9 Kamiyama M....Maeda S. (2007)
    5. Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling. (PubMed id 18500817)1, 9 Venkataraman V....Sharma R.K. (2008)
    6. Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. (PubMed id 11836243)1, 9 O'Callaghan D.W....Burgoyne R.D. (2002)
    7. Genome-wide association analysis of coffee drinking su ggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)1 Amin N....van Duijn C.M. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1 Cirulli E.T....Goldstein D.B. (2010)

    External Searches for NCALD gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing NCALD gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83988 HGNC: 7655 AceView: NCALD Ensembl:ENSG00000104490 euGenes: HUgn83988
    ECgene: NCALD H-InvDB: NCALD

    Other Databases showing NCALD gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NCALD gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCALD Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NCALD gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NCALD gene:
    Search GeneIP for patents involving NCALD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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