Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NCALD Gene

protein-coding   GIFtS: 64
GCID: GC08M102767

Neurocalcin Delta

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurocalcin Delta1 2
neurocalcin-delta2

External Ids:    HGNC: 76551   Entrez Gene: 839882   Ensembl: ENSG000001044907   OMIM: 6067225   UniProtKB: P616013   

Export aliases for NCALD gene to outside databases

Previous GC identifers: GC08M101704 GC08M102766 GC08M102367 GC08M102655 GC08M097897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCALD Gene:
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein
contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at
resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that
exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the
perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal
transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the
same protein; additional variants may exist but their biological validity has not been determined. (provided by
RefSeq, Jul 2008)

GeneCards Summary for NCALD Gene: 
NCALD (neurocalcin delta) is a protein-coding gene. Diseases associated with NCALD include alcoholic liver cirrhosis, and alcohol abuse, and among its related super-pathways are Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell and Activation of Kainate Receptors upon glutamate binding. GO annotations related to this gene include tubulin binding and calcium ion binding. An important paralog of this gene is HPCA.

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium
ions




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NCALD gene promoter:
         AML1a   HOXA3   ATF-2   FOXO3   FOXO3a   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNCALD promoter sequence
   Search SABiosciences Chromatin IP Primers for NCALD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCALD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22-q23

NCALD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCALD gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M102767:  view genomic region     (about GC identifiers)

Start:
102,698,770 bp from pter      End:
103,137,135 bp from pter
Size:
438,366 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601 (See protein sequence)
Recommended Name: Neurocalcin-delta  
Size: 193 amino acids; 22245 Da
Secondary accessions: P29554 Q8IYC3 Q9H0W2

Explore the universe of human proteins at neXtProt for NCALD: NX_P61601

Explore proteomics data for NCALD at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61601

  • NCALD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NCALD Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001035714.1  NP_001035715.1  NP_001035716.1  NP_001035717.1  NP_001035718.1  NP_001035719.1  NP_001035720.1  NP_114430.2  

    ENSEMBL proteins: 
     ENSP00000220931   ENSP00000428105   ENSP00000430476   ENSP00000428781   ENSP00000429466  
     ENSP00000429255   ENSP00000430731   ENSP00000430925   ENSP00000429522   ENSP00000428598  
     ENSP00000428312   ENSP00000429493   ENSP00000429245   ENSP00000430064   ENSP00000430534  
     ENSP00000428193   ENSP00000430365   ENSP00000428093   ENSP00000429296   ENSP00000430578  
     ENSP00000429162   ENSP00000429347   ENSP00000379256   ENSP00000310587  
    Reactome Protein details: P61601
    Human Recombinant Protein Products for NCALD: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NCALD
    OriGene Protein Over-expression Lysate for NCALD
    OriGene MassSpec for NCALD 
    OriGene Custom Protein Services for NCALD
    GenScript Custom Purified and Recombinant Proteins Services for NCALD
    Novus Biologicals NCALD Proteins
    Novus Biologicals NCALD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NCALD
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005829cytosol TAS--
    GO:0030130clathrin coat of trans-Golgi network vesicle NAS11964161

    NCALD for ontologies           About GeneDecksing



    NCALD Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NCALD
    GenScript Custom Superior Antibodies Services for NCALD
    Novus Biologicals NCALD Antibody
    Abcam antibodies for NCALD
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for NCALD
    LSBio Antibodies in human, mouse, rat for NCALD 

    Assay Products for NCALD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NCALD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NCALD
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR001125 Recoverin
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P61601

    ProtoNet protein and cluster: P61601

    1 Blocks protein domain: IPB001125 Recoverin family signature

    UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
    Similarity: Belongs to the recoverin family
    Similarity: Contains 4 EF-hand domains


    NCALD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NCALD_HUMAN, P61601
    Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium
    ions

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA11964161
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0015631tubulin binding IDA11964161
    GO:0030276clathrin binding IDA11964161
         
    NCALD for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NCALD:
     Increased cell number in S and 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ncald):
     cardiovascular system  mortality/aging 

    NCALD for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NCALD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NCALD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NCALD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NCALD 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCALD
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NCALD (see all 49):
    hsa-miR-21* hsa-miR-513a-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-4314 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNCALD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NCALD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCALD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NCALD
    Sirion Biotech Customized adenovirus for overexpression of NCALD

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NCALD (see all 35)
    OriGene ORF clones in mouse, rat for NCALD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): NCALD (NM_001040628)
    Sino Biological Human cDNA Clone for NCALD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCALD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCALD
    Sirion Biotech Customized lentivirus for stable overexpression of NCALD 
                         Customized lentivirus expression plasmids for stable overexpression of NCALD 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NCALD
    Search LifeMap BioReagents cell lines for NCALD
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NCALD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.67
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
    2Prostacyclin signalling through prostacyclin receptor
    Activation of Kainate Receptors upon glutamate binding0.70
    Activation of Ca-permeable Kainate Receptor0.33
    Ionotropic activity of Kainate Receptors0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for NCALD (see all 6)
        Activation of Kainate Receptors upon glutamate binding
    Transmission across Chemical Synapses
    Activation of Ca-permeable Kainate Receptor
    Neuronal System
    Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell



    NCALD for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NCALD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/75 Interacting proteins for NCALD (P616012, 3 ENSP000002209314) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202062 I2D: score=1 STRING: ENSP00000250416
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007268synaptic transmission TAS--
    GO:0016192vesicle-mediated transport NAS11964161

    NCALD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NCALD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NCALD

    1 HMDB Compound for NCALD    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for NCALD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 5.71 3 11860183 (1), 11836243 (1), 17064702 (1), 18989702 (1)

    Search CenterWatch for drugs/clinical trials and news about NCALD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NCALD gene (8 alternative transcripts): 
    NM_001040624.1  NM_001040625.1  NM_001040626.1  NM_001040627.1  NM_001040628.1  NM_001040629.1  NM_001040630.1  NM_032041.2  

    Unigene Cluster for NCALD:

    Neurocalcin delta
    Hs.492427  [show with all ESTs]
    Unigene Representative Sequence: NM_001040630
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000220931 ENST00000521599 ENST00000519508 ENST00000522951 ENST00000522754
    ENST00000522448 ENST00000520690 ENST00000518727 ENST00000520425 ENST00000518166
    ENST00000522252 ENST00000517822 ENST00000524209 ENST00000517531 ENST00000521964
    ENST00000519098 ENST00000523923 ENST00000520346
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCALD
    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NCALD (see all 49):
    hsa-miR-21* hsa-miR-513a-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-4314 hsa-miR-30a hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNCALD 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NCALD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCALD
    Clone
    Products:
         
    OriGene clones in human, mouse for NCALD (see all 35)
    OriGene ORF clones in mouse, rat for NCALD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): NCALD (NM_001040628)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NCALD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCALD
    Sirion Biotech Customized lentivirus for stable overexpression of NCALD 
                         Customized lentivirus expression plasmids for stable overexpression of NCALD 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NCALD
    OriGene qSTAR qPCR primer pairs in human, mouse for NCALD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCALD
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCALD
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCALD

    Additional mRNA sequence: 

    AF052142.1 AF251061.1 AK055073.1 AK096515.1 AK314523.1 AL136612.1 BC009949.2 BC033319.1 
    BC036098.1 BC063428.1 

    24/27 DOTS entries (see all 27):

    DT.97776704  DT.95074105  DT.40284869  DT.95152300  DT.100794937  DT.95078929  DT.120647463  DT.95074116 
    DT.95107420  DT.100794935  DT.120647425  DT.120647410  DT.99942060  DT.120647420  DT.120647422  DT.120647449 
    DT.120647456  DT.120647478  DT.120647520  DT.92065407  DT.120647421  DT.120647429  DT.120647440  DT.120647472 

    24/199 AceView cDNA sequences (see all 199):

    AV728578 AI679992 BM719121 BX477769 BX460814 BI768254 BF115903 BQ101177 
    CD722496 AA457517 BX386910 BE858130 AI961653 BM449845 AA706200 BQ286771 
    BC009949 BP346768 H18390 AK096515 T34809 AA553580 AI457647 BP340623 

    GeneLoc Exon Structure

    5/21 Alternative Splicing Database (ASD) splice patterns (SP) for NCALD (see all 21)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^
    SP1:                                                  -     -     -                                                                                             
    SP2:                                -                 -     -     -     -     -     -     -     -           -     -     -     -     -     -     -     -     -   
    SP3:                                                  -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -     -   
    SP4:                                                  -     -     -     -     -     -     -     -                 -     -     -     -     -     -     -         
    SP5:                                -     -           -     -     -     -     -     -     -     -           -     -     -     -     -     -     -     -     -   

    ExUns: 21a · 21b ^ 22a · 22b · 22c · 22d · 22e · 22f ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26
    SP1:                                                                                    
    SP2:              -                                   -                                 
    SP3:              -                                   -                                 
    SP4:                                                                                    
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for NCALD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NCALD expression in normal human tissues (normalized intensities)      NCALD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCAAGGTT
    NCALD Expression
    About this image


    NCALD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             Subthalamic Nucleus   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Fibroblast
             Human Villous Mesenchymal Fibroblasts (HVMF)   
     
     Dermis (Uncategorized)    fully expand to see all 2 entries
             BH2 Dermal Fibroblasts   
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor

    See NCALD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NCALD

    SOURCE GeneReport for Unigene cluster: Hs.492427

    UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601
    Tissue specificity: Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine

        SABiosciences Custom PCR Arrays for NCALD
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NCALD
    OriGene qSTAR qPCR primer pairs in human, mouse for NCALD
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NCALD
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCALD
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCALD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NCALD gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ncald1 , 5 neurocalcin delta1, 5 92.57(n)1
    100(a)1
      15 (14.94 cM)5
    525891  NM_134094.41  NP_598855.21 
     373661755 
    chicken
    (Gallus gallus)
    Aves NCALD1 neurocalcin delta 86.36(n)
    99.48(a)
      396048  NM_205143.1  NP_990474.1 
    lizard
    (Anolis carolinensis)
    Reptilia HPCA6
    NCALD6
    Uncharacterized protein
    91(a)
    100(a)
    possible ortholog
    1 ↔ 1
    1(147593421-147706274)
    4(14161827-14238527)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054982.12   -- 84.26(n)    BC054982.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ncalda1 neurocalcin delta a 81.35(n)
    97.93(a)
      556178  NM_001114410.1  NP_001107882.1 


    ENSEMBL Gene Tree for NCALD (if available)
    TreeFam Gene Tree for NCALD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NCALD gene
    HPCA2  KCNIP32  KCNIP42  KCNIP12  GUCA1A2  RCVRN2  HPCAL12  GUCA1B2  
    KCNIP22  HPCAL42  NCS12  GUCA1C2  VSNL12  
    18/22 SIMAP similar genes for NCALD using alignment to 18 protein entries:     NCALD_HUMAN (see all proteins) (see all similar genes):
    DKFZp781K1922    HPCAL1    VSNL1    HPCA    HPCAL4    NCS1
    RCVRN    KCNIP4    KCNIP3    GUCA1A    KCNIP2    GUCA1B
    KCNIP1    DKFZp686E1183    CALM2    CALM1    PPP3R2    GUCA1C

    NCALD for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NCALD
    PGOHUM00000257195 PGOHUM00000257196


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8516 SNPs in NCALD are shown (see all 8516)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs342054531,2
    C,F--97949517(+) AAAAA-/A/AA/A
    AAA
    /AAAAA
    GAAGA
    8 -- int12NA CSA 4
    rs342274111,2
    C--98209810(+) AAAAA-/A/AA  
            
    GCCCA
    7 -- int11NA 2
    rs168681981,2
    C,F,H--102698284(+) CTACAG/TTAACG 8 -- ds500129Minor allele frequency- T:0.40NA NS EA WA CSA 2918
    rs1129809581,2
    C,F--102698454(+) TCCCAC/TTGAAG 8 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1179371351,2
    C,F--102698488(+) TTTATT/GGTACC 8 -- ds50011Minor allele frequency- G:0.07EA 120
    rs1420753891,2
    --102698570(+) AAGGAA/GGCCCA 8 -- ds50010--------
    rs1507402091,2
    --102698593(+) GGATGA/CCTTTG 8 -- ds50010--------
    rs1894090771,2
    --102698621(+) AGCAGC/GCTCTC 8 -- ds50010--------
    rs1927696601,2
    --102698624(+) AGCCTC/TTCTCA 8 -- ds50010--------
    rs1848003741,2
    --102698657(+) CCTTGG/TGTCAC 8 -- ds50010--------

    HapMap Linkage Disequilibrium report for NCALD (102698770 - 102948770 bp, first 250kb of NCALD)

    Structural Variations
         Database of Genomic Variants (DGV) 10/24 variations for NCALD (see all 24):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662515CNV Deletion23128226
    esv2421949CNV Deletion20811451
    esv2664408CNV Deletion23128226
    esv2737371CNV Deletion23290073
    esv2605083CNV Insertion19546169
    esv274627CNV Insertion20981092
    esv269392CNV Insertion20981092
    nsv507478CNV Insertion20534489
    nsv8371CNV Loss18304495
    nsv465749CNV Loss19166990


    Human Gene Mutation Database (HGMD): NCALD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NCALD
    DNA2.0 Custom Variant and Variant Library Synthesis for NCALD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606722    OMIM disorders: --

    8 diseases for NCALD:    About MalaCards
    alcoholic liver cirrhosis    alcohol abuse    pancreatic endocrine tumor    liver cirrhosis
    alcoholism    neuronitis    retinitis    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for NCALD:
    Alcoholic liver cirrhosis

    NCALD for disorders           About GeneDecksing

    Genetic Association Database (GAD): NCALD
    Human Genome Epidemiology (HuGE) Navigator: NCALD (2 documents)

    Export disorders for NCALD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NCALD gene, integrated from 9 sources (see all 39):
    (articles sorted by number of sources associating them with NCALD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD). (PubMed id 11267673)1, 2, 3, 9 Wang W.... Mao Y. (2001)
    2. Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. (PubMed id 17671797)1, 4, 9 Kamiyama M....Maeda S. (2007)
    3. Genome-wide association analysis of coffee drinking su ggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)1, 4 Amin N....van Duijn C.M. (2012)
    4. Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling. (PubMed id 18500817)1, 9 Venkataraman V....Sharma R.K. (2008)
    9. Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. (PubMed id 11836243)1, 9 O'Callaghan D.W....Burgoyne R.D. (2002)
    10. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83988 HGNC: 7655 AceView: NCALD Ensembl:ENSG00000104490 euGenes: HUgn83988
    ECgene: NCALD H-InvDB: NCALD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NCALD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NCALD gene:
    Search GeneIP for patents involving NCALD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NCALD  
     OriGene qPCR primer pairs and template standards for NCALD   OriGene Protein Over-expression Lysate for NCALD  
     OriGene MassSpec something-or-other for NCALD   OriGene clones in human, mouse for NCALD  
     OriGene qSTAR qPCR primer pairs in human, mouse for NCALD   OriGene Purified Protein for NCALD  
     OriGene ORF clones in mouse, rat for NCALD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NCALD   OriGene Custom Protein Services for NCALD  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NCALD
     QIAGEN SeqTarget long-range PCR primers for resequencing NCALD
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCALD
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NCALD
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCALD
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NCALD
     GenScript Custom Purified and Recombinant Proteins Services for NCALD GenScript cDNA clones with any tag delivered in your preferred vector for NCALD
     GenScript Custom Assay Services for NCALD GenScript Custom Superior Antibodies Services for NCALD
     GenScript Custom overexpressing Cell Line Services for NCALD CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NCALD promoter
     Search Chromatin IP Primers for NCALD
     RT2 qPCR Primer Assay in human, mouse, rat NCALD
     Search GNC Networks for NCALD
     SABiosciences Custom PCR Arrays for NCALD
     Search Tocris compounds for NCALD
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NCALD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NCALD antibodies
     NCALD proteins
     NCALD lysates
     Antibodies for NCALD
     See all of Abcam's Antibodies, Kits and Proteins for NCALD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NCALD




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NCALD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD
     SwitchGear 3'UTR luciferase reporter plasmids for NCALD
     SwitchGear Promoter luciferase reporter plasmids for NCALD
     ThermoFisher Antibodies for NCALD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NCALD
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NCALD
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NCALD
    Customized:
     lentivirus for stable overexpression of NCALD
     lentivirus expression plasmids for stable overexpression of NCALD
     adenovirus for overexpression of NCALD
     LSBio Antibodies in human, mouse, rat for NCALD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NCALD gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4