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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NCALD Gene

protein-coding GIFtS: 62
GCID: GC08M102767

neurocalcin delta

Explore 9 diseases affiliated with
NCALD via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neurocalcin Delta¹ ²
Neurocalcin-Delta¹

External Ids:	HGNC: 7655¹	Entrez Gene: 83988²	Ensembl: ENSG00000104490⁷	OMIM: 606722⁵	UniProtKB: P61601³

Export aliases for NCALD gene to outside databases

Previous GC identifers: GC08M101704 GC08M102766 GC08M102367 GC08M102655 GC08M097897

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NCALD:

This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein

contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at

resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the

myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear

trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction.

Several alternatively spliced variants of this gene have been determined, all of which encode the same protein;

additional variants may exist but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601

Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NCALD gene promoter:
AML1a HOXA3 ATF-2 FOXO3 FOXO3a FOXO3b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NCALD promoter sequence

Search SABiosciences Chromatin IP Primers for NCALD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NCALD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22-q23

NCALD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NCALD gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M102767: view genomic region (about GC identifiers)

Start:	102,698,770 bp from pter	End:	103,137,135 bp from pter
Size:	438,366 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601 (See protein sequence)

Recommended Name: Neurocalcin-delta

Size: 193 amino acids; 22245 Da

Secondary accessions: P29554 Q8IYC3 Q9H0W2

Explore the universe of human proteins at neXtProt for NCALD: NX_P61601

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P61601

NCALD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_001035714.1 NP_001035715.1 NP_001035716.1 NP_001035717.1 NP_001035718.1 NP_001035719.1 NP_001035720.1 NP_114430.2

ENSEMBL proteins:

ENSP00000220931 ENSP00000428105 ENSP00000430476 ENSP00000428781 ENSP00000429466

ENSP00000429255 ENSP00000430731 ENSP00000430925 ENSP00000429522 ENSP00000428598

ENSP00000428312 ENSP00000429493 ENSP00000429245 ENSP00000430064 ENSP00000430534

ENSP00000428193 ENSP00000430365 ENSP00000428093 ENSP00000429296 ENSP00000430578

ENSP00000429162 ENSP00000429347 ENSP00000379256 ENSP00000310587

Reactome Protein details: P61601
Human Recombinant Protein Products for NCALD:

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	Novus Biologicals NCALD Proteins Novus Biologicals NCALD Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NCALD
	Browse Proteins at Uscn

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005829	cytosol	TAS	--
GO:0030130	clathrin coat of trans-Golgi network vesicle	NAS	11964161

NCALD for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NCALD for domains About GeneDecksing

5 InterPro domains/families:

IPR018247 EF_Hand_1_Ca_BS

IPR001125 Recoverin

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR018248 EF-hand

Graphical View of Domain Structure for InterPro Entry P61601

ProtoNet protein and cluster: P61601

1 Blocks protein family: IPB001125 Recoverin family signature

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601

Similarity: Belongs to the recoverin family

Similarity: Contains 4 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NCALD_HUMAN, P61601

Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IDA	11964161
GO:0005509	calcium ion binding	IEA	--
GO:0015631	tubulin binding	IDA	11964161
GO:0030276	clathrin binding	IDA	11964161
GO:0043014	alpha-tubulin binding	IEA	--

NCALD for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NCALD:

Increased cell number in S and

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NCALD

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		hsa-miR-21* hsa-miR-513a-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-4314 hsa-miR-30a hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: NCALD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NCALD (see all 13) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NCALD (see all 8) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	1.00			Neuronal System	0.67
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	0.72

G beta:gamma signalling through PLC beta

	Activation of Kainate Receptors upon glutamate binding	0.67			Ionotropic activity of Kainate Receptors	0.00
	Activation of Ca-permeable Kainate Receptor	0.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for NCALD (see all 6)

	Activation of Kainate Receptors upon glutamate binding
	Transmission across Chemical Synapses
	Activation of Ca-permeable Kainate Receptor
	Neuronal System
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell

NCALD for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NCALD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/68 Interacting proteins for NCALD (P61601^{2, 3} ENSP00000220931⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PARP2	Q9UGN5²^,³, ENSP00000250416⁴	MINT-8202062 I2D: score=1 STRING: ENSP00000250416
DTX2	Q86UW9²^,³, ENSP00000322885⁴	MINT-67559 I2D: score=5 STRING: ENSP00000322885
ACTB	P60709³, ENSP00000349960⁴	I2D: score=4 STRING: ENSP00000349960
CLTC	Q00610³, ENSP00000269122⁴	I2D: score=3 STRING: ENSP00000269122
PNP	P00491³, ENSP00000354532⁴	I2D: score=2 STRING: ENSP00000354532

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007268	synaptic transmission	TAS	--
GO:0016192	vesicle-mediated transport	NAS	11964161

NCALD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NCALD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NCALD

1 HMDB Compound for NCALD About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

1 Novoseek chemical compound relationship for NCALD gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	5.71	3	11860183 (1), 11836243 (1), 17064702 (1), 18989702 (1)

Search CenterWatch for drugs/clinical trials and news about NCALD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NCALD gene (8 alternative transcripts):

NM_001040624.1 NM_001040625.1 NM_001040626.1 NM_001040627.1 NM_001040628.1 NM_001040629.1 NM_001040630.1 NM_032041.2

Unigene Cluster for NCALD:

Neurocalcin delta

Hs.492427 [show with all ESTs]

Unigene Representative Sequence: NM_001040630

18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):

ENST00000220931 ENST00000521599 ENST00000519508 ENST00000522951 ENST00000522754

ENST00000522448 ENST00000520690 ENST00000518727 ENST00000520425 ENST00000518166

ENST00000522252 ENST00000517822 ENST00000524209 ENST00000517531 ENST00000521964

ENST00000519098 ENST00000523923 ENST00000520346

miRNA Products:		OriGene 3'-UTR Clone (see all 8): NCALD Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NCALD
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NCALD (see all 49):
		hsa-miR-21* hsa-miR-513a-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-508-3p hsa-miR-4314 hsa-miR-30a hsa-miR-149

		SwitchGear 3'UTR luciferase reporter plasmid: NCALD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NCALD (see all 7) OriGene shRNA RFP: NCALD OriGene siRNA: NCALD
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NCALD

Additional cDNA sequence:

AF052142.1 AF251061.1 AK055073.1 AK096515.1 AK314523.1 AL136612.1 BC009949.2 BC033319.1

BC036098.1 BC063428.1

24/27 DOTS entries (see all 27):

DT.97776704 DT.95074105 DT.40284869 DT.95152300 DT.100794937 DT.95078929 DT.120647463 DT.95074116

DT.95107420 DT.100794935 DT.120647425 DT.120647410 DT.99942060 DT.120647420 DT.120647422 DT.120647449

DT.120647456 DT.120647478 DT.120647520 DT.92065407 DT.120647421 DT.120647429 DT.120647440 DT.120647472

24/199 AceView cDNA sequences (see all 199):

BM683082 AA706200 AV708382 BP346768 H18390 AW203994 BM449845 T09286

BX460814 BC009949 BX477769 AK096515 AI961653 CD722496 BE858130 CK823095

BM719121 T33765 N48605 BX386910 AI017000 AI566944 BC033319 T33307

GeneLoc Exon Structure

5/21 Alternative Splicing Database (ASD) splice patterns (SP) for NCALD (see all 21) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	·	17c	^	18	^	19	^	20	^
SP1:																	-		-		-
SP2:											-						-		-		-		-		-		-		-		-				-		-		-		-		-		-		-		-		-
SP3:																	-		-		-		-		-		-		-		-						-		-		-		-		-		-		-		-
SP4:																	-		-		-		-		-		-		-		-						-		-		-		-		-		-		-
SP5:											-		-				-		-		-		-		-		-		-		-				-		-		-		-		-		-		-		-		-

ExUns:	21a	·	21b	^	22a	·	22b	·	22c	·	22d	·	22e	·	22f	^	23	^	24a	·	24b	·	24c	^	25	^	26
SP1:
SP2:					-												-
SP3:					-												-
SP4:
SP5:					-

ECgene alternative splicing isoforms for NCALD

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NCALD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCAAGGTT

About this image

NCALD expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Pancreas

Islets of Langerhans

Mature Beta Cells

Pancreas

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

See NCALD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NCALD

SOURCE GeneReport for Unigene cluster: Hs.492427

UniProtKB/Swiss-Prot: NCALD_HUMAN, P61601

Tissue specificity: Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine

SABiosciences Custom PCR Arrays for NCALD

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NCALD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NCALD gene from 5/21 species (see all 21) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NCALD¹	neurocalcin delta	86.36(n) 99.48(a)		396048 NM_205143.1 NP_990474.1
lizard (Anolis carolinensis)	Reptilia	NCALD⁶	--	100(a)	1 ↔ 1	4(14226135-14235514)
African clawed frog (Xenopus laevis)	Amphibia	BC054982.1²	--	84.26(n)		BC054982.1
zebrafish (Danio rerio)	Actinopterygii	ncalda¹	neurocalcin delta a	81.35(n) 97.93(a)		556178 NM_001114410.1 NP_001107882.1
fruit fly (Drosophila melanogaster)	Insecta	Nca³	negative regulation of phosphorylation calcium more	87(a) (best of 2)		3 76D8 --

ENSEMBL Gene Tree for NCALD (if available)
TreeFam Gene Tree for NCALD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NCALD gene

HPCA² KCNIP3² KCNIP4² GUCA1A² KCNIP1² RCVRN² HPCAL1² GUCA1B²

KCNIP2² HPCAL4² NCS1² VSNL1² GUCA1C²

18/23 SIMAP similar genes for NCALD using alignment to 18 protein entries: NCALD_HUMAN (see all proteins) (see all similar genes):

DKFZp781K1922 HPCAL1 VSNL1 HPCA HPCAL4 NCS1

RCV1 RCVRN KCNIP4 KCNIP3 GUCA1A KCNIP2

GUCA1B KCNIP1 DKFZp686E1183 CALM3 CALM1 PPP3R2

NCALD for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NCALD
PGOHUM00000257195 PGOHUM00000257196

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs16868198^1,2	C,F,H	--	102698284(+)	`CTACAG/TTAACG`	8	--	ds500¹		29		NA NS EA WA CSA	2918
rs112980958^1,2		--	102698454(+)	`TCCCAC/TTGAAG`	8	--	ds500¹		1		CSA	2
rs117937135^1,2	F	--	102698488(+)	`TTTATT/GGTACC`	8	--	ds500¹		1		EA	120
rs142075389^1,2		--	102698570(+)	`AAGGAA/GGCCCA`	8	--	ds500¹		0	--	--	--	--
rs150740209^1,2		--	102698593(+)	`GGATGA/CCTTTG`	8	--	ds500¹		0	--	--	--	--
rs189409077^1,2		--	102698621(+)	`AGCAGC/GCTCTC`	8	--	ds500¹		0	--	--	--	--
rs192769660^1,2		--	102698624(+)	`AGCCTC/TTCTCA`	8	--	ds500¹		0	--	--	--	--
rs184800374^1,2		--	102698657(+)	`CCTTGG/TGTCAC`	8	--	ds500¹		0	--	--	--	--
rs189454739^1,2		--	102698787(+)	`AAAAAC/TATGCT`	8	--	ut3¹		0	--	--	--	--
rs181649464^1,2		--	102698804(+)	`CCAGGC/GAAGAG`	8	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NCALD (102698770 - 102948770 bp, first 250kb of NCALD)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 13 variations for NCALD
12 CNVs: 52324 10265 95607 52325 95608 65213 95609 95606 33050 1799 82713 100439
1 Indel: 82714
Human Gene Mutation Database (HGMD): NCALD

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NCALD for disorders           About GeneDecksing

OMIM gene information: 606722    OMIM disorders: --

9 diseases for NCALD:    About MalaCards

alcoholic liver cirrhosis alcohol abuse liver cirrhosis pancreatic endocrine tumors

neuronitis alcoholism nephropathy pancreatitis

retinitis

1 disease from the University of Copenhagen DISEASES database for NCALD:

Alcoholic liver cirrhosis

Human Genome Epidemiology (HuGE) Navigator: NCALD (2 documents)

Export disorders for NCALD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NCALD gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with NCALD)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD). (PubMed id 11267673)^{1, 2, 3, 9} Wang W.... Mao Y. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. (PubMed id 17671797)^{1, 9} Kamiyama M....Maeda S. (2007)
Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling. (PubMed id 18500817)^{1, 9} Venkataraman V....Sharma R.K. (2008)
Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. (PubMed id 11836243)^{1, 9} O'Callaghan D.W....Burgoyne R.D. (2002)
Genome-wide association analysis of coffee drinking su ggests association with CYP1A1/CYP1A2 and NRCAM. (PubMed id 21876539)¹ Amin N....van Duijn C.M. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)¹ Cirulli E.T....Goldstein D.B. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83988	HGNC: 7655	AceView: NCALD	Ensembl:ENSG00000104490	euGenes: HUgn83988
ECgene: NCALD	H-InvDB: NCALD

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NCALD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NCALD gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NCALD gene:
Search GeneIP for patents involving NCALD

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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