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Aliases for NCALD Gene

Aliases for NCALD Gene

  • Neurocalcin Delta 2 3 5

External Ids for NCALD Gene

Previous GeneCards Identifiers for NCALD Gene

  • GC08M102766
  • GC08M102367
  • GC08M102655
  • GC08M102767
  • GC08M097897
  • GC08M102698

Summaries for NCALD Gene

Entrez Gene Summary for NCALD Gene

  • This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NCALD Gene

NCALD (Neurocalcin Delta) is a Protein Coding gene. Among its related pathways are Transmission across Chemical Synapses and Olfactory Signaling Pathway. GO annotations related to this gene include calcium ion binding and clathrin binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for NCALD Gene

  • May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCALD Gene

Genomics for NCALD Gene

Regulatory Elements for NCALD Gene

Promoters for NCALD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCALD on UCSC Golden Path with GeneCards custom track

Genomic Location for NCALD Gene

Chromosome:
8
Start:
101,686,542 bp from pter
End:
102,124,907 bp from pter
Size:
438,366 bases
Orientation:
Minus strand

Genomic View for NCALD Gene

Genes around NCALD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCALD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCALD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCALD Gene

Proteins for NCALD Gene

  • Protein details for NCALD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61601-NCALD_HUMAN
    Recommended name:
    Neurocalcin-delta
    Protein Accession:
    P61601
    Secondary Accessions:
    • P29554
    • Q8IYC3
    • Q9H0W2

    Protein attributes for NCALD Gene

    Size:
    193 amino acids
    Molecular mass:
    22245 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NCALD Gene

Proteomics data for NCALD Gene at MOPED

Post-translational modifications for NCALD Gene

  • Ubiquitination at Lys 50
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NCALD Gene

Domains & Families for NCALD Gene

Gene Families for NCALD Gene

Protein Domains for NCALD Gene

Suggested Antigen Peptide Sequences for NCALD Gene

Graphical View of Domain Structure for InterPro Entry

P61601

UniProtKB/Swiss-Prot:

NCALD_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with NCALD: view

Function for NCALD Gene

Molecular function for NCALD Gene

UniProtKB/Swiss-Prot Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions.

Gene Ontology (GO) - Molecular Function for NCALD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 11964161
GO:0015276 ligand-gated ion channel activity TAS --
GO:0015631 tubulin binding IDA 11964161
genes like me logo Genes that share ontologies with NCALD: view
genes like me logo Genes that share phenotypes with NCALD: view

Animal Models for NCALD Gene

MGI Knock Outs for NCALD:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NCALD Gene

Localization for NCALD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCALD Gene COMPARTMENTS Subcellular localization image for NCALD gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NCALD Gene

Pathways & Interactions for NCALD Gene

genes like me logo Genes that share pathways with NCALD: view

Gene Ontology (GO) - Biological Process for NCALD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007268 synaptic transmission TAS --
GO:0019722 calcium-mediated signaling IEA --
genes like me logo Genes that share ontologies with NCALD: view

No data available for SIGNOR curated interactions for NCALD Gene

Drugs & Compounds for NCALD Gene

(1) Drugs for NCALD Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with NCALD: view

Transcripts for NCALD Gene

Unigene Clusters for NCALD Gene

Neurocalcin delta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCALD Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^
SP1: - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - -
SP9: - - - - - - -
SP10: - - -
SP11: - - -
SP12: - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - - - - -
SP17: - -
SP18: -
SP19: - -
SP20:
SP21:

ExUns: 21a · 21b ^ 22a · 22b · 22c · 22d · 22e · 22f ^ 23 ^ 24a · 24b · 24c ^ 25 ^ 26
SP1:
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:
SP7:
SP8: -
SP9: - -
SP10: - -
SP11: -
SP12: -
SP13:
SP14:
SP15:
SP16: -
SP17:
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for NCALD Gene

GeneLoc Exon Structure for
NCALD
ECgene alternative splicing isoforms for
NCALD

Expression for NCALD Gene

mRNA expression in normal human tissues for NCALD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCALD Gene

This gene is overexpressed in Brain - Cortex (x7.8), Brain - Frontal Cortex (BA9) (x7.3), and Brain - Anterior cingulate cortex (BA24) (x4.5).

Protein differential expression in normal tissues from HIPED for NCALD Gene

This gene is overexpressed in Frontal cortex (26.4), Salivary gland (11.7), and Brain (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCALD Gene



SOURCE GeneReport for Unigene cluster for NCALD Gene Hs.492427

mRNA Expression by UniProt/SwissProt for NCALD Gene

P61601-NCALD_HUMAN
Tissue specificity: Retina, cerebrum, cerebellum, brain stem, spinal cord, testis, ovary and small intestine.
genes like me logo Genes that share expression patterns with NCALD: view

Protein tissue co-expression partners for NCALD Gene

Primer Products

In Situ Assay Products

Orthologs for NCALD Gene

This gene was present in the common ancestor of animals.

Orthologs for NCALD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCALD 35
  • 93.09 (n)
  • 100 (a)
NCALD 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCALD 35
  • 95.34 (n)
  • 100 (a)
NCALD 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncald 35
  • 92.57 (n)
  • 100 (a)
Ncald 16
Ncald 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCALD 35
  • 99.48 (n)
  • 100 (a)
NCALD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncald 35
  • 93.09 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia NCALD 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCALD 35
  • 86.36 (n)
  • 99.48 (a)
NCALD 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCALD 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ncald 35
  • 84.11 (n)
  • 99.48 (a)
Str.14728 35
zebrafish
(Danio rerio)
Actinopterygii ncalda 35
  • 81.35 (n)
  • 97.93 (a)
ncalda 36
  • 98 (a)
OneToMany
ncaldb 36
  • 94 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7646 37
  • 47 (a)
Nca 37
  • 87 (a)
worm
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 50 (a)
ncs-3 37
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 77 (a)
OneToMany
Species with no ortholog for NCALD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NCALD Gene

ENSEMBL:
Gene Tree for NCALD (if available)
TreeFam:
Gene Tree for NCALD (if available)

Paralogs for NCALD Gene

Pseudogenes.org Pseudogenes for NCALD Gene

genes like me logo Genes that share paralogs with NCALD: view

Variants for NCALD Gene

Sequence variations from dbSNP and Humsavar for NCALD Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs727753 -- 101,883,518(-) CTGAG(A/T)CAATA intron-variant
rs604234 -- 102,093,523(-) ACCTA(A/C)CTTCT intron-variant
rs611528 -- 102,106,466(-) TGTGT(A/G)TATAT intron-variant
rs472471 -- 101,849,426(+) TACCT(A/T)GGTTA intron-variant
rs472638 -- 101,866,801(+) cctaa(C/T)tggtg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NCALD Gene

Variant ID Type Subtype PubMed ID
esv2605083 CNV Insertion 19546169
esv269392 CNV Insertion 20981092
esv274627 CNV Insertion 20981092
dgv466n21 CNV Loss 19592680
nsv465749 CNV Loss 19166990
nsv507478 CNV Insertion 20534489
nsv831411 CNV Gain 17160897
nsv891231 CNV Gain 21882294
dgv7837n71 CNV Gain 21882294
dgv7838n71 CNV Gain 21882294
nsv891236 CNV Gain 21882294
nsv8371 CNV Loss 18304495
esv21888 CNV Loss 19812545
esv2664408 CNV Deletion 23128226
esv2737371 CNV Deletion 23290073
nsv438074 CNV Loss 16468122
nsv517149 CNV Loss 19592680
nsv818646 CNV Loss 17921354
esv2421949 CNV Deletion 20811451
nsv891238 CNV Gain 21882294
dgv7839n71 CNV Gain 21882294
esv2662515 CNV Deletion 23128226
nsv517893 CNV Loss 19592680
nsv523654 CNV Gain 19592680

Variation tolerance for NCALD Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NCALD Gene

HapMap Linkage Disequilibrium report
NCALD
Human Gene Mutation Database (HGMD)
NCALD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCALD Gene

Disorders for NCALD Gene

Relevant External Links for NCALD

Genetic Association Database (GAD)
NCALD
Human Genome Epidemiology (HuGE) Navigator
NCALD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCALD

No disorders were found for NCALD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCALD Gene

Publications for NCALD Gene

  1. Molecular cloning, mapping and characterization of the human neurocalcin delta gene (NCALD). (PMID: 11267673) Wang W. … Mao Y. (Biochim. Biophys. Acta 2001) 2 3 4 23 67
  2. Neurocalcin delta modulation of ROS-GC1, a new model of Ca(2+) signaling. (PMID: 18500817) Venkataraman V. … Sharma R.K. (Biochemistry 2008) 3 23
  3. Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy. (PMID: 17671797) Kamiyama M. … Maeda S. (Hum. Genet. 2007) 3 23
  4. Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction. (PMID: 11836243) O'Callaghan D.W. … Burgoyne R.D. (J. Biol. Chem. 2002) 3 23
  5. Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment. (PMID: 24939585) Fransen E. … Friedman R.A. (Eur. J. Hum. Genet. 2015) 3

Products for NCALD Gene

Sources for NCALD Gene

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