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Aliases for NBR2 Gene

Subcategory (RNA class) for NBR2 Gene

lncRNA

Quality Score for this RNA gene is

3

Aliases for NBR2 Gene

  • Neighbor Of BRCA1 Gene 2 (Non-Protein Coding) 2 3
  • Neighbor Of BRCA1 Gene 2 Protein 4
  • Non-Protein Coding RNA 192 2
  • Neighbor Of BRCA1 Gene 2 2
  • NCRNA00192 3

External Ids for NBR2 Gene

ORGUL Members for NBR2 Gene

Previous GeneCards Identifiers for NBR2 Gene

  • GC17P041024
  • GC17P043442
  • GC17P041186
  • GC17P041650
  • GC17P038531
  • GC17P041277
  • GC17P037043

Summaries for NBR2 Gene

Entrez Gene Summary for NBR2 Gene

  • This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 bases upstream of the last splice site for the transcript suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for NBR2 Gene

NBR2 (Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with NBR2 include breast cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR2 Gene

Genomics for NBR2 Gene

Regulatory Elements for NBR2 Gene

Transcription factor binding sites by QIAGEN in the NBR2 gene promoter:

Genomic Location for NBR2 Gene

Start:
43,125,583 bp from pter
End:
43,153,671 bp from pter
Size:
28,089 bases
Orientation:
Plus strand

Genomic View for NBR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NBR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBR2 Gene

Proteins for NBR2 Gene

  • Protein details for NBR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15453-NBR2_HUMAN
    Recommended name:
    Next to BRCA1 gene 2 protein
    Protein Accession:
    O15453
    Secondary Accessions:
    • Q3LRJ7

    Protein attributes for NBR2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12357 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation may occur

neXtProt entry for NBR2 Gene

Proteomics data for NBR2 Gene at MOPED

Post-translational modifications for NBR2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NBR2 Gene

Domains for NBR2 Gene

Gene Families for NBR2 Gene

HGNC:
  • LNCRNA :Long non-coding RNAs

Protein Domains for NBR2 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for NBR2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NBR2: view

No data available for UniProtKB/Swiss-Prot for NBR2 Gene

Function for NBR2 Gene

Phenotypes for NBR2 Gene

GenomeRNAi human phenotypes for NBR2:
genes like me logo Genes that share phenotypes with NBR2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NBR2 Gene

Localization for NBR2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NBR2 Gene COMPARTMENTS Subcellular localization image for NBR2 gene
Compartment Confidence
extracellular 2
mitochondrion 2
cytosol 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NBR2 Gene

Pathways for NBR2 Gene

SuperPathways for NBR2 Gene

No Data Available

Interacting Proteins for NBR2 Gene

Gene Ontology (GO) - Biological Process for NBR2 Gene

None

No data available for Pathways by source for NBR2 Gene

Transcripts for NBR2 Gene

Unigene Clusters for NBR2 Gene

Neighbor of BRCA1 gene 2 (non-protein coding):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NBR2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBR2 Gene

No ASD Table

Relevant External Links for NBR2 Gene

GeneLoc Exon Structure for
NBR2
ECgene alternative splicing isoforms for
NBR2

Expression for NBR2 Gene

mRNA expression in normal human tissues for NBR2 Gene

SOURCE GeneReport for Unigene cluster for NBR2 Gene Hs.373818

mRNA Expression by UniProt/SwissProt for NBR2 Gene

O15453-NBR2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NBR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for NBR2 Gene

Orthologs for NBR2 Gene

Evolution for NBR2 Gene

ENSEMBL:
Gene Tree for NBR2 (if available)
TreeFam:
Gene Tree for NBR2 (if available)

No data available for Orthologs for NBR2 Gene

Paralogs for NBR2 Gene

Selected SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NBR2: view

No data available for Paralogs for NBR2 Gene

Variants for NBR2 Gene

Sequence variations from dbSNP and Humsavar for NBR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs799910 -- 43,127,544(+) caaat(C/G)tagtg intron-variant
rs1135214 -- 43,140,306(+) ctttg(C/T)aataa intron-variant
rs1554062 -- 43,135,049(+) GGAGG(G/T)TACTT intron-variant
rs1554063 -- 43,135,128(+) CCTGC(C/T)AGTTC intron-variant
rs1554064 -- 43,135,134(+) AGTTC(C/G)TAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NBR2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
esv2672913 CNV Deletion 23128226
nsv457743 CNV Loss 19166990
nsv908259 CNV Loss 21882294
nsv470587 CNV Loss 18288195

Relevant External Links for NBR2 Gene

HapMap Linkage Disequilibrium report
NBR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBR2 Gene

Disorders for NBR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NBR2 Gene including...

Search for NBR2 Gene in MalaCards »
genes like me logo Genes that share disorders with NBR2: view

No data available for UniProtKB/Swiss-Prot for NBR2 Gene

Publications for NBR2 Gene

  1. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu C.-F. … Solomon E. (Hum. Mol. Genet. 1997) 2 3 4
  2. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen T.C. … Goss P.E. (Biochim. Biophys. Acta 2005) 2 3
  3. Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. (PMID: 16052033) Auriol E. … Dante R. (Nucleic Acids Res. 2005) 3
  4. Comparative analysis of cancer genes in the human and chimpanzee genomes. (PMID: 16438707) Puente X.S. … LA^pez-OtA-n C. (BMC Genomics 2006) 3
  5. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PMID: 21989022) Garcia-Casado Z. … Lopez-Guerrero J.A. (BMC Med. Genet. 2011) 3

Products for NBR2 Gene

Sources for NBR2 Gene

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