NBR2 Gene

Aliases
for NBR2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC17P041024 GC17P043442 GC17P041186 GC17P041650 GC17P038531 GC17P037043

Summaries
for NBR2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for NBR2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000017.10  NC_018928.2  NT_010783.16  

Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NBR2

NBR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041277:  view genomic region     (about GC identifiers)

Proteins
for NBR2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for NBR2: NX_O15453

Explore proteomics data for NBR2 at MOPED


See NBR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

NBR2 Human Recombinant Protein Products:

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	Novus Biologicals NBR2 Protein
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for NBR2
	Search GeneTex for Proteins for NBR2
	antibodies-online proteins for NBR2 (3 products)
	Search antibodies-online for peptides for NBR2

NBR2 Antibody Products:

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	Novus Biologicals NBR2 Antibody
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	ThermoFisher Antibodies for NBR2
	antibodies-online antibodies for NBR2

NBR2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for NBR2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NBR2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for NBR2
	Search antibodies-online for kits for NBR2

Domains /
Families
for NBR2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: O15453

Function
for NBR2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Localization
for NBR2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for NBR2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for NBR2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for NBR2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for NBR2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for NBR2:none

NBR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGCCGGGAGG

About this image

Primer Products:		Browse OriGene qPCR
		Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NBR2
		QuantiTect SYBR Green Assays in human, mouse, rat NBR2
		QuantiFast Probe-based Assays in human, mouse, rat NBR2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR2

Orthologs
for NBR2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for NBR2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for NBR2 gene

3 SIMAP similar genes for NBR2 using alignment to 2 protein entries:     NBR2_HUMAN (see all proteins):

ARL17A    ARL17B    ARL17

Find genes that share paralogs with NBR2           About GenesLikeMe

Genomic Variants
for NBR2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NBR2 (see all 373)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1837963231,2		--	41279529(+)	TGTAAA/GCGCAC	1	--	int1		0	--	--	--	--
rs80770351,2	C,F	--	41279534(+)	acgcaC/Tcaatc	1	--	int1		2		NA	4
rs7999101,2	C,F,A	--	41279561(+)	caaatG/Ctagtg	1	--	int1		4		MN NA EA	250
rs1478727581,2		--	41279633(+)	GTATAG/TCTAGC	1	--	int1		0	--	--	--	--
rs1416646321,2		--	41279762(+)	CCCGCG/TGGGTG	1	--	int1		0	--	--	--	--
rs344101381,2	C,F	--	41279770(-)	GCCACT/CGGCAC	1	--	int1		9		MN NA WA CSA EA	373
rs359811661,2	C,F	--	41279837(-)	GTCTCT/GATCTC	1	--	int1		5		MN NA WA CSA	9
rs129477821,2	C,F,A	--	41279882(+)	taaaaG/Agacaa	1	--	int1		6		MN NA WA CSA	11
rs1128817751,2	C	--	41279884(+)	AAAAG-/ACAAAAT	1	--	int1		1		CSA	2
rs1814206371,2		--	41279885(+)	AAAGAC/GAAAAT	1	--	int1		0	--	--	--	--

HapMap Linkage Disequilibrium report for NBR2 (41277600 - 41305688 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for NBR2:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2672913	CNV	Deletion	23128226
nsv457743	CNV	Loss	19166990
nsv470587	CNV	Loss	18288195
nsv908259	CNV	Loss	21882294
esv33998	OTHER	Inversion	15654335

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing NBR2

DNA2.0 Custom Variant and Variant Library Synthesis for NBR2

Disorders / Diseases
for NBR2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for NBR2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NBR2 gene, integrated from 10 sources (see all 13): (articles sorted by number of sources associating them with NBR2)

Utopia: connect your pdf to the dynamic world of online information

1. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PubMed id 9215675)^{1, 2, 3} Xu C.-F....Solomon E. (Hum. Mol. Genet. 1997)
2. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PubMed id 15777733)^{1, 3} Suen T.C....Goss P.E. (Biochim. Biophys. Acta 2005)
3. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)¹ Garcia-Casado Z....Lopez-Guerrero J.A. (BMC Med. Genet. 2011)
4. Comparative analysis of cancer genes in the human and chimpanzee genomes. (PubMed id 16438707)¹ Puente X.S....LA^pez-OtA-n C. (BMC Genomics 2006)
5. Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. (PubMed id 16052033)¹ Auriol E....Dante R. (Nucleic Acids Res. 2005)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Structural evolution of the BRCA1 genomic region in primates. (PubMed id 15533724)¹ Jin H....Roberts R.G. (Genomics 2004)
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
9. Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671)¹ Dimitrov S.... Forejt J. (Gene 2001)
10. Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. (PubMed id 11508855)¹ Dimitrov S.D....Forejt J. (Folia Biol. (Praha) 2001)

External Searches for NBR2 gene

Genome Databases showing NBR2 gene

Other Databases showing NBR2 gene

Specialized Databases showing NBR2 gene

Products
for NBR2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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