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NBR2 Gene(RNA Gene)

Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)

GCID:
GC17P043125
GIFtS:
29
Genes Participants
UDN Logo

Aliases for NBR2 Gene

Subcategory (RNA class) for NBR2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for NBR2 Gene

  • Neighbor Of BRCA1 Gene 2 (Non-Protein Coding) 2 3 5
  • Neighbor Of BRCA1 Gene 2 Protein 4
  • Non-Protein Coding RNA 192 2
  • Neighbor Of BRCA1 Gene 2 2
  • NCRNA00192 3

External Ids for NBR2 Gene

Previous GeneCards Identifiers for NBR2 Gene

  • GC17P041024
  • GC17P043442
  • GC17P041186
  • GC17P041650
  • GC17P038531
  • GC17P041277
  • GC17P037043

Summaries for NBR2 Gene

Entrez Gene Summary for NBR2 Gene

  • This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]

GeneCards Summary for NBR2 Gene

NBR2 (Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR2 Gene

Genomics for NBR2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NBR2 Gene

Enhancers for NBR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G043168 1.7 FANTOM5 ENCODE dbSUPER 82.7 +45.5 45484 5.0 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SSRP1 GLIS1 NBR2 TMEM106A NBR1 ENSG00000267002
GH17G043366 1.7 Ensembl ENCODE dbSUPER 77.7 +243.1 243132 4.0 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 NBR2 DHX8 HMGN1P29 LINC00910 ASB16-AS1 ENSG00000267340 ENSG00000267002 PSME3 NBR1 MEOX1
GH17G043018 1.7 FANTOM5 ENCODE dbSUPER 76.3 -105.1 -105051 5.0 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF766 FOS KLF13 NBR2 HMGN2P15 VAT1 NAGLU IFI35
GH17G043314 1.6 Ensembl ENCODE dbSUPER 75.7 +190.3 190330 2.6 HNRNPUL1 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF143 NBR2 AOC3 NBR1 RND2 VAT1 AOC4P PTGES3L PSMC3IP LINC00854 GC17P043358
GH17G043174 1.4 Ensembl ENCODE dbSUPER 80.2 +51.0 50968 3.5 FOXA2 ATF1 ARID4B ZNF48 YY1 REST PPARG KAT8 SSRP1 MIER3 NBR2 RND2 VAT1 PTGES3L ENSG00000267002 TMEM106A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NBR2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NBR2 gene promoter:

Genomic Location for NBR2 Gene

Chromosome:
17
Start:
43,125,583 bp from pter
End:
43,153,671 bp from pter
Size:
28,089 bases
Orientation:
Plus strand

Genomic View for NBR2 Gene

Genes around NBR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NBR2 Gene

Proteins for NBR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NBR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15453-NBR2_HUMAN
    Recommended name:
    Next to BRCA1 gene 2 protein
    Protein Accession:
    O15453
    Secondary Accessions:
    • Q3LRJ7

    Protein attributes for NBR2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12357 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation may occur.

neXtProt entry for NBR2 Gene

Post-translational modifications for NBR2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NBR2 Gene

Domains & Families for NBR2 Gene

Gene Families for NBR2 Gene

HGNC:

Protein Domains for NBR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NBR2: view

No data available for UniProtKB/Swiss-Prot for NBR2 Gene

Function for NBR2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
genes like me logo Genes that share phenotypes with NBR2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NBR2 Gene

Localization for NBR2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NBR2 Gene

Pathways & Interactions for NBR2 Gene

SuperPathways for NBR2 Gene

PathCards logo More details on SuperPathways for NBR2
No Data Available

Interacting Proteins for NBR2 Gene

Gene Ontology (GO) - Biological Process for NBR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NBR2 Gene

Drugs & Compounds for NBR2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NBR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NBR2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(175) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NBR2 Gene

Neighbor of BRCA1 gene 2 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBR2 Gene

No ASD Table

Relevant External Links for NBR2 Gene

GeneLoc Exon Structure for
NBR2
ECgene alternative splicing isoforms for
NBR2

Expression for NBR2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NBR2 Gene

mRNA expression in normal human tissues for NBR2 Gene
mRNA expression by BioGPS for NBR2 GenemRNA expression by GTEx for NBR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NBR2 Gene:

NBR2

SOURCE GeneReport for Unigene cluster for NBR2 Gene:

Hs.373818

mRNA Expression by UniProt/SwissProt for NBR2 Gene:

O15453-NBR2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NBR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBR2 Gene

Orthologs for NBR2 Gene

Evolution for NBR2 Gene

ENSEMBL:
Gene Tree for NBR2 (if available)
TreeFam:
Gene Tree for NBR2 (if available)

No data available for Orthologs for NBR2 Gene

Paralogs for NBR2 Gene

(3) SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NBR2: view

No data available for Paralogs for NBR2 Gene

Variants for NBR2 Gene

Sequence variations from dbSNP and Humsavar for NBR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs273902778 Pathogenic 43,124,036(-) AGAAA(-/A)TCTTA nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs386833395 Pathogenic 43,124,028(-) CTTAG(-/AG)TGTCC nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs397509299 Pathogenic 43,124,042(-) CTATG(C/T)AGAAA nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs397509309 Pathogenic 43,124,028(-) TTAGA(-/A)GTGTC nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs397509310 Pathogenic 43,124,023(-) GTGTC(-/TGTC)CCATC nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NBR2 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv457743 CNV loss 19166990
nsv470587 CNV loss 18288195
nsv575053 CNV loss 21841781
nsv978428 CNV duplication 23825009

Relevant External Links for NBR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NBR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NBR2 Gene

Disorders for NBR2 Gene

Relevant External Links for NBR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NBR2

No disorders were found for NBR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NBR2 Gene

Publications for NBR2 Gene

  1. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu C.-F. … Solomon E. (Hum. Mol. Genet. 1997) 2 3 4 64
  2. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. (PMID: 26999735) Liu X. … Gan B. (Nat. Cell Biol. 2016) 2 3 64
  3. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen T.C. … Goss P.E. (Biochim. Biophys. Acta 2005) 2 3 64
  4. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. (PMID: 27792451) Liu X. … Gan B. (Cell Cycle 2016) 3 64
  5. An lncRNA switch for AMPK activation. (PMID: 27152502) Liu X. … Gan B. (Cell Cycle 2016) 3 64

Products for NBR2 Gene

Sources for NBR2 Gene

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