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NBR2 Gene(RNA Gene)

Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)

GCID:
GC17P043125
GIFtS:
25
Genes Participants
UDN Logo

Aliases for NBR2 Gene

Subcategory (RNA class) for NBR2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for NBR2 Gene

  • Neighbor Of BRCA1 Gene 2 (Non-Protein Coding) 2 3 5
  • Neighbor Of BRCA1 Gene 2 Protein 4
  • Non-Protein Coding RNA 192 2
  • Neighbor Of BRCA1 Gene 2 2
  • NCRNA00192 3

External Ids for NBR2 Gene

Previous GeneCards Identifiers for NBR2 Gene

  • GC17P041024
  • GC17P043442
  • GC17P041186
  • GC17P041650
  • GC17P038531
  • GC17P041277
  • GC17P037043

Summaries for NBR2 Gene

Entrez Gene Summary for NBR2 Gene

  • This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]

GeneCards Summary for NBR2 Gene

NBR2 (Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for NBR2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR2 Gene

Genomics for NBR2 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NBR2 Gene

Promoters and enhancers for NBR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I043124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 642.1 0.0 -2 2.8 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 NBR2 PIR48082 PIR61659 BRCA1 DHX8 HMGN1P29 ENSG00000267758 LINC00910 PSME3 RND2
GH17I043168 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 82.8 +45.5 45483 5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 NBR1 BRCA1 BRCA1P1 ENSG00000267002 ENSG00000267340 LOC101929767 PIR60622 NBR2 TMEM106A C17orf53
GH17I043018 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 76.3 -105.1 -105051 5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ZNF766 VAT1 NBR2 HMGN2P15 NAGLU IFI35
GH17I043024 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 88.7 -100.5 -100544 2 HDGF CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF766 RND2 VAT1 NBR2 HMGN1P29 CCR10 ENSG00000267758 ENSG00000267002 LINC00910 DHX8 HSD17B1P1
GH17I043322 Enhancer 1.5 Ensembl ENCODE dbSUPER 107.3 +197.6 197580 1.6 CLOCK MLX ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 ZNF416 ZNF143 ENSG00000267340 UBTF ASB16-AS1 ENSG00000267002 DHX8 HMGN1P29 TMUB2 NBR2 LINC00910 PLEKHH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NBR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NBR2 gene promoter:

Genomic Locations for NBR2 Gene

Genomic Locations for NBR2 Gene
chr17:43,125,583-43,153,671
(GRCh38/hg38)
Size:
28,089 bases
Orientation:
Plus strand
chr17:41,277,600-41,305,688
(GRCh37/hg19)

Genomic View for NBR2 Gene

Genes around NBR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NBR2 Gene

Proteins for NBR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NBR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15453-NBR2_HUMAN
    Recommended name:
    Next to BRCA1 gene 2 protein
    Protein Accession:
    O15453
    Secondary Accessions:
    • Q3LRJ7

    Protein attributes for NBR2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12357 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation may occur.

neXtProt entry for NBR2 Gene

Post-translational modifications for NBR2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NBR2 Gene

Domains & Families for NBR2 Gene

Gene Families for NBR2 Gene

HGNC:

Protein Domains for NBR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NBR2: view

No data available for UniProtKB/Swiss-Prot for NBR2 Gene

Function for NBR2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for NBR2 Gene

genes like me logo Genes that share phenotypes with NBR2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NBR2 Gene

Localization for NBR2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NBR2 Gene

Pathways & Interactions for NBR2 Gene

SuperPathways for NBR2 Gene

PathCards logo More details on SuperPathways for NBR2
No Data Available

Interacting Proteins for NBR2 Gene

Gene Ontology (GO) - Biological Process for NBR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NBR2 Gene

Drugs & Compounds for NBR2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NBR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NBR2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(69) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NBR2 Gene

Neighbor of BRCA1 gene 2 (non-protein coding):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBR2 Gene

No ASD Table

Relevant External Links for NBR2 Gene

GeneLoc Exon Structure for
NBR2
ECgene alternative splicing isoforms for
NBR2

Expression for NBR2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NBR2 Gene

mRNA expression in normal human tissues for NBR2 Gene
mRNA expression by BioGPS for NBR2 GenemRNA expression by GTEx for NBR2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NBR2 Gene:

NBR2

SOURCE GeneReport for Unigene cluster for NBR2 Gene:

Hs.373818

mRNA Expression by UniProt/SwissProt for NBR2 Gene:

O15453-NBR2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NBR2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBR2 Gene

Orthologs for NBR2 Gene

Evolution for NBR2 Gene

ENSEMBL:
Gene Tree for NBR2 (if available)
TreeFam:
Gene Tree for NBR2 (if available)

No data available for Orthologs for NBR2 Gene

Paralogs for NBR2 Gene

(3) SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NBR2: view

No data available for Paralogs for NBR2 Gene

Variants for NBR2 Gene

Sequence variations from dbSNP and Humsavar for NBR2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1057517546 uncertain-significance, Breast-ovarian cancer, familial 1 43,125,168(+) C/A/G/T upstream_transcript_variant
rs1057517547 uncertain-significance, Breast-ovarian cancer, familial 1 43,125,212(+) C/A upstream_transcript_variant
rs1057517555 uncertain-significance, Breast-ovarian cancer, familial 1 43,125,169(+) CG/GC upstream_transcript_variant
rs1064793052 uncertain-significance, Hereditary cancer-predisposing syndrome, not specified 43,124,017(+) C/A/G upstream_transcript_variant
rs111462026 benign, Breast-ovarian cancer, familial 1 43,124,741(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NBR2 Gene

Variant ID Type Subtype PubMed ID
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv457743 CNV loss 19166990
nsv470587 CNV loss 18288195
nsv575053 CNV loss 21841781
nsv978428 CNV duplication 23825009

Additional Variant Information for NBR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NBR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NBR2 Gene

Disorders for NBR2 Gene

Additional Disease Information for NBR2

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NBR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NBR2 Gene

Publications for NBR2 Gene

  1. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu CF … Solomon E (Human molecular genetics 1997) 2 3 4 58
  2. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. (PMID: 26999735) Liu X … Gan B (Nature cell biology 2016) 2 3 58
  3. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen TC … Goss PE (Biochimica et biophysica acta 2005) 2 3 58
  4. Induction of the long noncoding RNA NBR2 from the bidirectional BRCA1 promoter under hypoxic conditions. (PMID: 28249151) Wiedmeier JE … Turker MS (Mutation research 2017) 3 58
  5. lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. (PMID: 27792451) Liu X … Gan B (Cell cycle (Georgetown, Tex.) 2016) 3 58

Products for NBR2 Gene

Sources for NBR2 Gene

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