Aliases for NBR2 Gene
Subcategory (RNA class) for NBR2 Gene
Quality Score for this RNA gene is
Aliases for NBR2 Gene
External Ids for NBR2 Gene
- HGNC: 20691
- Entrez Gene: 10230
- Ensembl: ENSG00000198496
- UniProtKB: O15453
Previous GeneCards Identifiers for NBR2 Gene
- GC17P041024
- GC17P043442
- GC17P041186
- GC17P041650
- GC17P038531
- GC17P041277
- GC17P037043
Summaries for NBR2 Gene
-
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016]
GeneCards Summary for NBR2 Gene
NBR2 (Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR2 Gene
Genomics for NBR2 Gene
GeneHancer (GH) Regulatory Elements for NBR2 Gene
Regulatory Element Products
Genomic Locations for NBR2 Gene
- chr17:43,125,583-43,153,671
- (GRCh38/hg38)
- Size:
- 28,089 bases
- Orientation:
- Plus strand
- chr17:41,277,600-41,305,688
- (GRCh37/hg19)
Genomic View for NBR2 Gene
- Cytogenetic band:
-
- 17q21.31 by Ensembl
- 17q21.31 by Entrez Gene
- 17q21.31 by HGNC


RefSeq DNA sequence for NBR2 Gene
Proteins for NBR2 Gene
-
Protein details for NBR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O15453-NBR2_HUMAN
- Recommended name:
- Next to BRCA1 gene 2 protein
- Protein Accession:
- O15453
- Q3LRJ7
Protein attributes for NBR2 Gene
- Size:
- 112 amino acids
- Molecular mass:
- 12357 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation may occur.
Post-translational modifications for NBR2 Gene
Antibody Products
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-
Abcam proteins for NBR2
Assay Products
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No data available for DME Specific Peptides for NBR2 Gene
Domains & Families for NBR2 Gene
Gene Families for NBR2 Gene
Suggested Antigen Peptide Sequences for NBR2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for NBR2 Gene
Function for NBR2 Gene
Phenotypes From GWAS Catalog for NBR2 Gene
Phenotypes for NBR2 Gene
- GenomeRNAi human phenotypes for NBR2:
Animal Model Products
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-
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CRISPR Products
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- Overview of 34 available NBR2 gene related products
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-
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miRNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NBR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NBR2 Gene
Localization for NBR2 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NBR2 Gene
Transcripts for NBR2 Gene
mRNA/cDNA for NBR2 Gene
- (1) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NBR2 Gene
CRISPR Products
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- genomics-online: gRNA clones - Search results for 34 available NBR2 gene related products
- Overview of 34 available NBR2 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
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Inhibitory RNA Products
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- Overview of 34 available NBR2 gene related products
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Clone Products
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- VectorBuilder custom plasmid, inducible vectors for NBR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NBR2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NBR2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NBR2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NBR2 Gene:
NBR2SOURCE GeneReport for Unigene cluster for NBR2 Gene:
Hs.373818mRNA Expression by UniProt/SwissProt for NBR2 Gene:
O15453-NBR2_HUMANPrimer Products
- genomics-online: primer clones - Search results for 34 available NBR2 gene related products
- Overview of 34 available NBR2 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NBR2 Gene
Orthologs for NBR2 Gene
No data available for Orthologs for NBR2 Gene
Paralogs for NBR2 Gene
(3) SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:
No data available for Paralogs for NBR2 Gene
Variants for NBR2 Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1057517546 | uncertain-significance, Breast-ovarian cancer, familial 1 | 43,125,168(+) | C/A/G/T | upstream_transcript_variant | |
rs1057517547 | uncertain-significance, Breast-ovarian cancer, familial 1 | 43,125,212(+) | C/A | upstream_transcript_variant | |
rs1057517555 | uncertain-significance, Breast-ovarian cancer, familial 1 | 43,125,169(+) | CG/GC | upstream_transcript_variant | |
rs1064793052 | uncertain-significance, Hereditary cancer-predisposing syndrome, not specified | 43,124,017(+) | C/A/G | upstream_transcript_variant | |
rs111462026 | benign, Breast-ovarian cancer, familial 1 | 43,124,741(+) | C/T | upstream_transcript_variant |
Additional Variant Information for NBR2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NBR2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NBR2 Gene
Disorders for NBR2 Gene
Additional Disease Information for NBR2
No disorders were found for NBR2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NBR2 Gene
Publications for NBR2 Gene
- Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu CF … Solomon E (Human molecular genetics 1997) 2 3 4 58
- LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. (PMID: 26999735) Liu X … Gan B (Nature cell biology 2016) 2 3 58
- Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen TC … Goss PE (Biochimica et biophysica acta 2005) 2 3 58
- Induction of the long noncoding RNA NBR2 from the bidirectional BRCA1 promoter under hypoxic conditions. (PMID: 28249151) Wiedmeier JE … Turker MS (Mutation research 2017) 3 58
- lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. (PMID: 27792451) Liu X … Gan B (Cell cycle (Georgetown, Tex.) 2016) 3 58
Products for NBR2 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for NBR2
- VectorBuilder custom plasmid, inducible vectors for NBR2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NBR2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available NBR2 related products ranked by validation data
- antibodies-online: Search results for available NBR2 related products ranked by validation data
- antibodies-online: Search results for available NBR2 related products ranked by validation data
- Search GeneTex for Antibodies for NBR2
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- genomics-online: cdna clones - Search results for 34 available NBR2 gene related products
- Overview of 34 available NBR2 gene related products
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- Overview of 34 available NBR2 gene related products
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- Overview of 34 available NBR2 gene related products
Sources for NBR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
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- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
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- (135) Horizon
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- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew