|
|
neighbor of BRCA1 gene 2 (non-protein coding)(Previous name: neighbor of BRCA1 gene 2 )
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Aliases
for NBR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): lncRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)1 2 | | NCRNA001921 2 | | Neighbor Of BRCA1 Gene 21 | | Neighbor Of BRCA1 Gene 2 Protein3 |
| External Ids: | HGNC: 206911 | Entrez Gene: 102302 | Ensembl: ENSG000001984967 | UniProtKB: O154533 | | ORGUL members: | |
|---|
| NONCODE:n383181 n386184 n383180 n383179 | |
Export aliases for NBR2 gene to outside databasesPrevious GC identifers: GC17P041024 GC17P043442 GC17P041186 GC17P041650 GC17P038531 GC17P037043
|---|
Summaries
for NBR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NBR2:
This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidenceindicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individuallyby distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includesa region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codonis more than 55 bases upstream of the last splice site for the transcript suggesting that the transcript is subject tononsense-mediated decay. Therefore, this gene does not appear to encode a protein. (provided by RefSeq, Jul 2008)
|
Genomic Views
for NBR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NBR2 gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for NBR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21NBR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P041277: view genomic region
(about GC identifiers)
Start:
|
41,277,600 bp from pter |
End:
|
41,305,688 bp from pter |
Size:
|
28,089 bases |
Orientation:
|
plus strand |
ORGUL member locations:
Legend (see complete legend)
 |
Proteins
for NBR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NBR2_HUMAN, O15453 (See
protein sequence)Recommended Name: Next to BRCA1 gene 2 protein Size: 112 amino acids; 12357 Da
Miscellaneous: BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcriptionfactors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation mayoccur
Secondary accessions: Q3LRJ7Explore the universe of human proteins at neXtProt for NBR2: NX_O15453
NBR2 Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products for NBR2:
NBR2 Antibody Products:
Assay Products for NBR2: |
Protein
Domains /
Families
for NBR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O15453 |
Function
for NBR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for NBR2:
Animal Models:
|
Pathways & Interactions
for NBR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NBR2
|
Drugs & Compounds
for NBR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NBR2
Search CenterWatch for drugs/clinical trials and news about NBR2 
|
Transcripts
for NBR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NBR2 gene: NM_005821.4 Unigene Clusters for NBR2: Neighbor of BRCA1 gene 2 (non-protein coding) Hs.373818 [show with all ESTs], Hs.559259 [show with all ESTs]Unigene Representative Sequences: BC034248, BQ8836414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000460115(uc002idg.3) ENST00000356906(uc002idf.3 uc010czb.2)
ENST00000467245(uc002idh.3) ENST00000587322
Additional cDNA sequence: BC000924.3 BT007332.1 24/37 DOTS entries (see all 37): DT.100832873 DT.92417048 DT.97858444 DT.120910787 DT.75190497 DT.40108675 DT.100816331 DT.120982774 DT.120983128 DT.87015353 DT.97838754 DT.120982812 DT.95340910 DT.75119216 DT.102839963 DT.87008244 DT.95263448 DT.99928669 DT.120983134 DT.437274 DT.91680369 DT.92464067 DT.95305503 DT.100728131 24/69 AceView cDNA sequences (see all 69): BQ286035 AY597810 BC034248 BQ019077 NM_005821 CD358597 BQ269397 BF935789 AW117709 BU552436 BM046519 AI633677 AL598622 BM806681 AU135669 AI613324 AV691787 BU542220 BF795183 CD103023 BC022065 AI561159 BX281508 AU156212
GeneLoc Exon Structure
|
Expression
for NBR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for NBR2:none
NBR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCGGGAGG
About this image
Genevestigator expression for NBR2
SOURCE GeneReport for Unigene clusters: Hs.373818 Hs.559259
UniProtKB/Swiss-Prot: NBR2_HUMAN, O15453Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for NBR2
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NBR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBR2 |
Orthologs
for NBR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NBR2 (if available)
TreeFam Gene Tree for NBR2 (if available) |
Paralogs
for NBR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NBR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NBR2 (41277600 - 41305688 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NBR2: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NBR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NBR2 for disorders About GeneDecksing
3  diseases for NBR2: About MalaCardsbilateral breast cancer sporadic breast cancer breast cancer
Export disorders for NBR2 gene to outside databases
|
Publications
for NBR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NBR2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with NBR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PubMed id 9215675)1, 2, 3 Xu C.-F....Solomon E. (1997)
- Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PubMed id 15777733)1, 3 Suen T.C....Goss P.E. (2005)
- A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)1 Garcia-Casado Z....Lopez-Guerrero J.A. (2011)
- Comparative analysis of cancer genes in the human and chimpanzee genomes. (PubMed id 16438707)1 Puente X.S....Lopez-Otin C. (2006)
- Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. (PubMed id 16052033)1 Auriol E....Dante R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Structural evolution of the BRCA1 genomic region in primates. (PubMed id 15533724)1 Jin H....Roberts R.G. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671)1 Dimitrov S.... Forejt J. (2001)
- Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. (PubMed id 11508855)1 Dimitrov S.D....Forejt J. (2001)
|
External Searches for NBR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NBR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NBR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NBR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NBR2 gene:
Search GeneIP for patents involving NBR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NBR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NBR2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NBR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NBR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBR2 |
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 |  |  |  | |
| | | | Search Tocris compounds for NBR2 |
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 | | | | |  |  |  |  | | | | Search ThermoFisher Antibodies for NBR2 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBR2 |
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