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NBR2 Gene(RNA Gene)

Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)

GCID:
GC17P043125
GIFtS:
25
Genes Participants
UDN Logo

Aliases for NBR2 Gene

Subcategory (RNA class) for NBR2 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for NBR2 Gene

  • Neighbor Of BRCA1 Gene 2 (Non-Protein Coding) 2 3 5
  • Neighbor Of BRCA1 Gene 2 Protein 4
  • Non-Protein Coding RNA 192 2
  • Neighbor Of BRCA1 Gene 2 2
  • NCRNA00192 3

External Ids for NBR2 Gene

Previous GeneCards Identifiers for NBR2 Gene

  • GC17P041024
  • GC17P043442
  • GC17P041186
  • GC17P041650
  • GC17P038531
  • GC17P041277
  • GC17P037043

Summaries for NBR2 Gene

Entrez Gene Summary for NBR2 Gene

  • This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 bases upstream of the last splice site for the transcript suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for NBR2 Gene

NBR2 (Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR2 Gene

Genomics for NBR2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for NBR2 Gene

Enhancers for NBR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NBR2 on UCSC Golden Path with GeneCards custom track

Promoters for NBR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NBR2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NBR2 gene promoter:

Genomic Location for NBR2 Gene

Chromosome:
17
Start:
43,125,583 bp from pter
End:
43,153,671 bp from pter
Size:
28,089 bases
Orientation:
Plus strand

Genomic View for NBR2 Gene

Genes around NBR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBR2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NBR2 Gene

Proteins for NBR2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NBR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15453-NBR2_HUMAN
    Recommended name:
    Next to BRCA1 gene 2 protein
    Protein Accession:
    O15453
    Secondary Accessions:
    • Q3LRJ7

    Protein attributes for NBR2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12357 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and differentiation may occur.

neXtProt entry for NBR2 Gene

Proteomics data for NBR2 Gene at MOPED

Post-translational modifications for NBR2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NBR2 Gene

Domains & Families for NBR2 Gene

Protein Domains for NBR2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NBR2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NBR2 Gene

Function for NBR2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Phenotypes for NBR2 Gene

GenomeRNAi human phenotypes for NBR2:
genes like me logo Genes that share phenotypes with NBR2: view

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NBR2 Gene

Localization for NBR2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NBR2 Gene

Pathways & Interactions for NBR2 Gene

SuperPathways for NBR2 Gene

PathCards logoMore details on SuperPathways for NBR2
No Data Available

Interacting Proteins for NBR2 Gene

Gene Ontology (GO) - Biological Process for NBR2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NBR2 Gene

Drugs & Compounds for NBR2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NBR2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for NBR2 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(69) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NBR2 Gene

Neighbor of BRCA1 gene 2 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBR2 Gene

No ASD Table

Relevant External Links for NBR2 Gene

GeneLoc Exon Structure for
NBR2
ECgene alternative splicing isoforms for
NBR2

Expression for NBR2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for NBR2 Gene

mRNA expression in normal human tissues for NBR2 Gene
mRNA expression by BioGPS for NBR2 GenemRNA expression by GTEx for NBR2 Gene

SOURCE GeneReport for Unigene cluster for NBR2 Gene Hs.373818

mRNA Expression by UniProt/SwissProt for NBR2 Gene

O15453-NBR2_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with NBR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NBR2 Gene

Orthologs for NBR2 Gene

Evolution for NBR2 Gene

ENSEMBL:
Gene Tree for NBR2 (if available)
TreeFam:
Gene Tree for NBR2 (if available)

No data available for Orthologs for NBR2 Gene

Paralogs for NBR2 Gene

(3) SIMAP similar genes for NBR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NBR2: view

No data available for Paralogs for NBR2 Gene

Variants for NBR2 Gene

Sequence variations from dbSNP and Humsavar for NBR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11657835 - 43,139,936(+) tgaca(C/G)aagga nc-transcript-variant
rs1709430 -- 43,128,405(+) catca(A/G)aagga intron-variant
rs1709431 -- 43,128,437(+) tttaa(A/G)aactg intron-variant
rs799910 -- 43,127,544(+) caaat(C/G)tagtg intron-variant
rs1814833 -- 43,129,584(+) ttctc(C/T)tgcct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NBR2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
esv2672913 CNV Deletion 23128226
nsv457743 CNV Loss 19166990
nsv908259 CNV Loss 21882294
nsv470587 CNV Loss 18288195

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for NBR2 Gene

Disorders for NBR2 Gene

Relevant External Links for NBR2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NBR2

No disorders were found for NBR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NBR2 Gene

Publications for NBR2 Gene

  1. Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PMID: 9215675) Xu C.-F. … Solomon E. (Hum. Mol. Genet. 1997) 2 3 4 67
  2. Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PMID: 15777733) Suen T.C. … Goss P.E. (Biochim. Biophys. Acta 2005) 2 3
  3. Functional characterization of BRCA1 gene variants by mini-gene splicing assay. (PMID: 24667779) Steffensen A.Y. … Hansen T.v. (Eur. J. Hum. Genet. 2014) 3
  4. A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PMID: 21989022) Garcia-Casado Z. … Lopez-Guerrero J.A. (BMC Med. Genet. 2011) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for NBR2 Gene

Sources for NBR2 Gene

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