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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NBR2 Gene

RNA gene GIFtS: 36
GCID: GC17P041277

Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)

(Previous name: neighbor of BRCA1 gene 2)

3 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)¹ ²
Neighbor Of BRCA1 Gene 2¹
Non-Protein Coding RNA 192¹
NCRNA00192²
Neighbor Of BRCA1 Gene 2 Protein³

External Ids:	HGNC: 20691¹	Entrez Gene: 10230²	Ensembl: ENSG00000198496⁷	UniProtKB: O15453³

ORGUL members:
	NONCODE¹⁴:n383179 n383181 n386184 n383180

Export aliases for NBR2 gene to outside databases

Previous GC identifers: GC17P041024 GC17P043442 GC17P041186 GC17P041650 GC17P038531 GC17P037043

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NBR2 Gene:

This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental

evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is

controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading

frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for

the putative ORF and the stop codon is more than 55 bases upstream of the last splice site for the transcript

suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to

encode a protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for NBR2 Gene:

NBR2 (neighbor of BRCA1 gene 2 (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with NBR2 include bilateral breast cancer, and sporadic breast cancer.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.2 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NBR2 gene promoter:
ATF-2 c-Jun
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for NBR2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBR2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21

NBR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBR2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P041277: view genomic region (about GC identifiers)

Start:	41,277,600 bp from pter	End:	41,305,688 bp from pter
Size:	28,089 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NBR2

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NBR2_HUMAN, O15453 (See protein sequence)

Recommended Name: Next to BRCA1 gene 2 protein

Size: 112 amino acids; 12357 Da

Miscellaneous: BRCA1 and NBR2 genes may be coregulated, depending on the relative abundance of specific

transcription factors. When balance between expression of the two genes is disrupted, abnormal cell growth and

differentiation may occur

Secondary accessions: Q3LRJ7

Explore the universe of human proteins at neXtProt for NBR2: NX_O15453

NBR2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : --

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: O15453

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for NBR2:

Synthetic lethal with Ras

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NBR2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NBR2

Search CenterWatch for drugs/clinical trials and news about NBR2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for NBR2 gene:

NM_005821.4

Unigene Clusters for NBR2:

Neighbor of BRCA1 gene 2 (non-protein coding)

Hs.373818 [show with all ESTs], Hs.559259 [show with all ESTs]

Unigene Representative Sequences: BC034248, BQ883641

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000460115(uc002idg.3) ENST00000356906(uc002idf.3 uc010czb.2)

ENST00000467245(uc002idh.3) ENST00000587322

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Additional mRNA sequence:

BC000924.3 BT007332.1

24/37 DOTS entries (see all 37):

DT.100832873 DT.92417048 DT.97858444 DT.120910787 DT.75190497 DT.40108675 DT.100816331 DT.120982774

DT.120983128 DT.87015353 DT.97838754 DT.120982812 DT.95340910 DT.75119216 DT.102839963 DT.87008244

DT.95263448 DT.99928669 DT.120983134 DT.437274 DT.91680369 DT.92464067 DT.95305503 DT.100728131

24/69 AceView cDNA sequences (see all 69):

AY597810 BQ286035 CD358597 NM_005821 BQ269397 BQ019077 BF935789 BC034248

CD103023 BU542220 BV179550 BV196057 AW117709 AI633677 BI259104 BM806681

AV691787 BU552436 U88573 BM046519 BC022065 AU135669 AA551672 AA463326

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for NBR2:none

NBR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TGCCGGGAGG

About this image

Genevestigator expression for NBR2

SOURCE GeneReport for Unigene clusters: Hs.373818 Hs.559259

UniProtKB/Swiss-Prot: NBR2_HUMAN, O15453

Tissue specificity: Ubiquitous

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for NBR2 (if available)
TreeFam Gene Tree for NBR2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NBR2 gene

3 SIMAP similar genes for NBR2 using alignment to 2 protein entries: NBR2_HUMAN (see all proteins):

ARL17A ARL17B ARL17

NBR2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183796323^1,2		--	41279529(+)	`TGTAAA/GCGCAC`	1	--	int¹		0	--	--	--	--
rs8077035^1,2	C,F	--	41279534(+)	`acgcaC/Tcaatc`	1	--	int¹		2		NA	4
rs799910^1,2	C,F,A	--	41279561(+)	`caaatG/Ctagtg`	1	--	int¹		4		MN NA EA	250
rs147872758^1,2		--	41279633(+)	`GTATAG/TCTAGC`	1	--	int¹		0	--	--	--	--
rs141664632^1,2		--	41279762(+)	`CCCGCG/TGGGTG`	1	--	int¹		0	--	--	--	--
rs34410138^1,2	C,F	--	41279770(-)	`GCCACT/CGGCAC`	1	--	int¹		9		MN NA WA CSA EA	373
rs35981166^1,2	C,F	--	41279837(-)	`GTCTCT/GATCTC`	1	--	int¹		5		MN NA WA CSA	9
rs12947782^1,2	C,F,A	--	41279882(+)	`taaaaG/Agacaa`	1	--	int¹		6		MN NA WA CSA	11
rs112881775^1,2	C	--	41279884(+)	`AAAAG-/ACAAAAT`	1	--	int¹		1		CSA	2
rs181420637^1,2		--	41279885(+)	`AAAGAC/GAAAAT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NBR2 (41277600 - 41305688 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for NBR2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2672913	CNV	Deletion	23128226
nsv457743	CNV	Loss	19166990
nsv470587	CNV	Loss	18288195
nsv908259	CNV	Loss	21882294
esv33998	OTHER	Inversion	15654335

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

3 diseases for NBR2: About MalaCards

bilateral breast cancer sporadic breast cancer breast cancer

NBR2 for disorders About GeneDecksing

Export disorders for NBR2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NBR2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with NBR2)

Utopia: connect your pdf to the dynamic
world of online information

Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene. (PubMed id 9215675)^{1, 2, 3} Xu C.-F....Solomon E. (1997)
Model of transcriptional regulation of the BRCA1-NBR2 bi-directional transcriptional unit. (PubMed id 15777733)^{1, 3} Suen T.C....Goss P.E. (2005)
A de novo complete BRCA1 gene deletion identified in a Spanish woman with early bilateral breast cancer. (PubMed id 21989022)¹ Garcia-Casado Z....Lopez-Guerrero J.A. (2011)
Comparative analysis of cancer genes in the human and chimpanzee genomes. (PubMed id 16438707)¹ Puente X.S....Lopez-Otin C. (2006)
Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus. (PubMed id 16052033)¹ Auriol E....Dante R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Structural evolution of the BRCA1 genomic region in primates. (PubMed id 15533724)¹ Jin H....Roberts R.G. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671)¹ Dimitrov S.... Forejt J. (2001)
Expression of BRCA1, NBR1 and NBR2 genes in human breast cancer cells. (PubMed id 11508855)¹ Dimitrov S.D....Forejt J. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10230	HGNC: 20691	AceView: NBR2	Ensembl:ENSG00000198496	euGenes: HUgn10230
ECgene: NBR2	H-InvDB: NBR2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NBR2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NBR2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NBR2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NBR2 gene:
Search GeneIP for patents involving NBR2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NBR2 antibodies
	NBR2 proteins

	Search for Antibodies for NBR2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for NBR2
	Custom Antibody / Protein Production Service
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	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Search LifeMap BioReagents cell lines for NBR2

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for NBR2
	Browse SwitchGear Promoter luciferase reporter plasmids for NBR2

ThermoFisher Antibodies for NBR2

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBR2

	inGenious Targeting Laboratory - Custom generated mouse model solutions for NBR2
	inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NBR2

Customized:

	lentivirus for stable overexpression of NBR2
	lentivirus expression plasmids for stable overexpression of NBR2
	adenovirus for overexpression of NBR2

Search LSBio for Antibodies for NBR2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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Category			TGFB1 (GIFtS: 73) transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NBR2 Gene

Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)

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NBR2 Gene

Neighbor Of BRCA1 Gene 2 (Non-Protein Coding)

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