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Aliases for NBR1 Gene

Aliases for NBR1 Gene

  • Neighbor Of BRCA1 Gene 1 2 3 5
  • Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125) 2 3
  • Cell Migration-Inducing Gene 19 Protein 3 4
  • M17S2 3 4
  • Membrane Component Chromosome 17 Surface Marker 2 4
  • Neighbor Of BRCA1 Gene 1 Protein 4
  • Migration-Inducing Protein 19 3
  • Protein 1A1-3B 4
  • B-Box Protein 3
  • KIAA0049 4
  • 1A1-3B 3
  • IAI3B 3
  • MIG19 3
  • 1A13B 4

External Ids for NBR1 Gene

Previous HGNC Symbols for NBR1 Gene

  • M17S2

Previous GeneCards Identifiers for NBR1 Gene

  • GC17P9L0001
  • GC17P038578
  • GC17P041322
  • GC17P037088

Summaries for NBR1 Gene

Entrez Gene Summary for NBR1 Gene

  • The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for NBR1 Gene

NBR1 (Neighbor Of BRCA1 Gene 1) is a Protein Coding gene. Diseases associated with NBR1 include inclusion body myositis and synucleinopathy. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

UniProtKB/Swiss-Prot for NBR1 Gene

  • Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Gene Wiki entry for NBR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR1 Gene

Genomics for NBR1 Gene

Regulatory Elements for NBR1 Gene

Promoters for NBR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NBR1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NBR1 gene promoter:

Genomic Location for NBR1 Gene

Chromosome:
17
Start:
43,170,471 bp from pter
End:
43,211,689 bp from pter
Size:
41,219 bases
Orientation:
Plus strand

Genomic View for NBR1 Gene

Genes around NBR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBR1 Gene

Proteins for NBR1 Gene

  • Protein details for NBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14596-NBR1_HUMAN
    Recommended name:
    Next to BRCA1 gene 1 protein
    Protein Accession:
    Q14596
    Secondary Accessions:
    • Q13173
    • Q15026
    • Q5J7Q8
    • Q96GB6
    • Q9NRF7

    Protein attributes for NBR1 Gene

    Size:
    966 amino acids
    Molecular mass:
    107413 Da
    Quaternary structure:
    • Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.
    SequenceCaution:
    • Sequence=BAA06417.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NBR1 Gene

    Alternative splice isoforms for NBR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NBR1 Gene

Proteomics data for NBR1 Gene at MOPED

Post-translational modifications for NBR1 Gene

  • Ubiquitination at Lys 464, Lys 499, Lys 515, Lys 537, Lys 627, and Lys 887
  • Modification sites at PhosphoSitePlus

Other Protein References for NBR1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NBR1 (NBR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NBR1

No data available for DME Specific Peptides for NBR1 Gene

Domains & Families for NBR1 Gene

Gene Families for NBR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14596

UniProtKB/Swiss-Prot:

NBR1_HUMAN :
  • The PB1 domain mediates interaction with SQSTM1.
  • Contains 1 ZZ-type zinc finger.
Domain:
  • The PB1 domain mediates interaction with SQSTM1.
  • Contains 1 PB1 domain.
  • Contains 1 UBA domain.
Similarity:
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with NBR1: view

Function for NBR1 Gene

Molecular function for NBR1 Gene

UniProtKB/Swiss-Prot Function:
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
genes like me logo Genes that share phenotypes with NBR1: view

Animal Models for NBR1 Gene

MGI Knock Outs for NBR1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NBR1

miRNA for NBR1 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NBR1 Gene

Localization for NBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBR1 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911). {ECO:0000250 UniProtKB:Q501R9, ECO:0000269 PubMed:19250911}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NBR1 Gene COMPARTMENTS Subcellular localization image for NBR1 gene
Compartment Confidence
cytosol 5
extracellular 5
endosome 4
lysosome 4
vacuole 4
nucleus 3
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IEA --
GO:0005770 late endosome ISS --
GO:0005829 cytosol IDA 19250911
GO:0031430 M band IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NBR1: view

Pathways & Interactions for NBR1 Gene

SuperPathways for NBR1 Gene

No Data Available

SIGNOR curated interactions for NBR1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032872 regulation of stress-activated MAPK cascade ISS --
genes like me logo Genes that share ontologies with NBR1: view

No data available for Pathways by source for NBR1 Gene

Drugs & Compounds for NBR1 Gene

No Compound Related Data Available

Transcripts for NBR1 Gene

Unigene Clusters for NBR1 Gene

Neighbor of BRCA1 gene 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: - -
SP12:
SP13: - - - -
SP14: - - - - - - -
SP15: - - -
SP16:
SP17:

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP1:
SP2: - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7:
SP8: - -
SP9: - -
SP10: - - -
SP11:
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for NBR1 Gene

GeneLoc Exon Structure for
NBR1
ECgene alternative splicing isoforms for
NBR1

Expression for NBR1 Gene

mRNA expression in normal human tissues for NBR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NBR1 Gene

This gene is overexpressed in Testis (37.1) and Tlymphocyte (28.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NBR1 Gene



SOURCE GeneReport for Unigene cluster for NBR1 Gene Hs.277721

genes like me logo Genes that share expression patterns with NBR1: view

Protein tissue co-expression partners for NBR1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NBR1 Gene

Orthologs for NBR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NBR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NBR1 35
  • 90.03 (n)
  • 87.97 (a)
NBR1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NBR1 35
  • 88.87 (n)
  • 87.61 (a)
NBR1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nbr1 35
  • 86.42 (n)
  • 85.06 (a)
Nbr1 16
Nbr1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NBR1 35
  • 98.62 (n)
  • 97.93 (a)
NBR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nbr1 35
  • 86.63 (n)
  • 84.61 (a)
oppossum
(Monodelphis domestica)
Mammalia NBR1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NBR1 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NBR1 35
  • 64.34 (n)
  • 63.47 (a)
NBR1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NBR1 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nbr1 35
  • 61.48 (n)
  • 53.99 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC555713 35
  • 56.22 (n)
  • 49.47 (a)
nbr1 36
  • 39 (a)
OneToMany
NBR1 (2 of 2) 36
  • 39 (a)
OneToMany
Species with no ortholog for NBR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NBR1 Gene

ENSEMBL:
Gene Tree for NBR1 (if available)
TreeFam:
Gene Tree for NBR1 (if available)

Paralogs for NBR1 Gene

No data available for Paralogs for NBR1 Gene

Variants for NBR1 Gene

Sequence variations from dbSNP and Humsavar for NBR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_016106 -
rs1565163 -- 43,209,323(-) TGAGG(C/T)GGGCG intron-variant
rs2306829 -- 43,201,789(-) AGGCT(A/G)ATCAT intron-variant
rs2356310 -- 43,207,570(+) TTGCC(C/T)AGGGC intron-variant
rs1399323 -- 43,180,313(-) CCTAT(A/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NBR1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
esv2672913 CNV Deletion 23128226
esv2672005 CNV Deletion 23128226
nsv908260 CNV Gain 21882294
nsv510712 CNV Loss 20534489

Variation tolerance for NBR1 Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.10; 93.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NBR1 Gene

HapMap Linkage Disequilibrium report
NBR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBR1 Gene

Disorders for NBR1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NBR1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inclusion body myositis
  • nonaka myopathy
synucleinopathy
  • alpha synucleinopathies
- elite association - COSMIC cancer census association via MalaCards
Search NBR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NBR1

Genetic Association Database (GAD)
NBR1
Human Genome Epidemiology (HuGE) Navigator
NBR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NBR1
genes like me logo Genes that share disorders with NBR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBR1 Gene

Publications for NBR1 Gene

  1. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PMID: 8069304) Campbell I.G. … Black D.M. (Hum. Mol. Genet. 1994) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. p38(MAPK)-regulated induction of p62 and NBR1 after photodynamic therapy promotes autophagic clearance of ubiquitin aggregates and reduces reactive oxygen species levels by supporting Nrf2-antioxidant signaling. (PMID: 24269898) Rubio N. … Agostinis P. (Free Radic. Biol. Med. 2014) 3
  4. The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome. (PMID: 24413169) Jones S. … Heath J.K. (J. Cell. Sci. 2014) 3
  5. Functional characterization of BRCA1 gene variants by mini-gene splicing assay. (PMID: 24667779) Steffensen A.Y. … Hansen T.v. (Eur. J. Hum. Genet. 2014) 3

Products for NBR1 Gene

Sources for NBR1 Gene

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