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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NBR1 Gene

protein-coding GIFtS: 54
GCID: GC17P041322

neighbor of BRCA1 gene 1

(Previous names: membrane component, chromosome 17, surface marker 2 (ovarian...)
(Previous symbol: M17S2)

Explore 7 diseases affiliated with
NBR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neighbor Of BRCA1 Gene 1¹ ²		Neighbor Of BRCA1 Gene 1 Protein² ³
M17S2¹ ² ³ ⁵		Protein 1A1-3B² ³
1A1-3B¹ ²		CA125¹
Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125)¹ ²		Migration-Inducing Protein 19²
KIAA0049¹ ³		Next To BRCA1 Gene 1 Protein²
Cell Migration-Inducing Gene 19 Protein² ³		1A13B³
Membrane Component Chromosome 17 Surface Marker 2² ³

External Ids:	HGNC: 6746¹	Entrez Gene: 4077²	Ensembl: ENSG00000188554⁷	OMIM: 166945⁵	UniProtKB: Q14596³

Export aliases for NBR1 gene to outside databases

Previous GC identifers: GC17P9L0001 GC17P038578 GC17P037088

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NBR1:

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The

encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but

the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close

proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been

identified for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596

Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

Gene Wiki entry for NBR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NBR1 gene promoter:
SRF p53
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NBR1 promoter sequence

Search SABiosciences Chromatin IP Primers for NBR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31

NBR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBR1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P041322: view genomic region (about GC identifiers)

Start:	41,322,498 bp from pter	End:	41,363,708 bp from pter
Size:	41,211 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596 (See protein sequence)

Recommended Name: Next to BRCA1 gene 1 protein

Size: 966 amino acids; 107413 Da

Subunit: Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN,

RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and

ubiquitinated proteins

Subcellular location: Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line

(By similarity). Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes

for degradation

Caution: Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125

Sequence caution: Sequence=BAA06417.2; Type=Erroneous initiation;

5 PDB 3D structures from and Proteopedia for NBR1:

1WJ6 (3D)

2BKF (3D)

2CP8 (3D)

2G4S (3D)

2L8J (3D)

Secondary accessions: Q13173 Q15026 Q5J7Q8 Q96GB6 Q9NRF7

Alternative splicing: 2 isoforms: Q14596-1 Q14596-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NBR1: NX_Q14596

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q14596

NBR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_005890.2 NP_114064.1 NP_114068.1

ENSEMBL proteins:

ENSP00000343479 ENSP00000466071 ENSP00000437545 ENSP00000466667 ENSP00000467816

ENSP00000411250 ENSP00000373963

Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for NBR1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000407	pre-autophagosomal structure	IEA	--
GO:0005764	lysosome	IEA	--
GO:0005770	late endosome	ISS	--
GO:0005776	colocalizes with autophagic vacuole	ISS	--
GO:0005829	cytosol	IDA	19250911

NBR1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NBR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NBR1 for domains About GeneDecksing

4 InterPro domains/families:

IPR000270 OPR_PB1

IPR015940 UBA/transl_elong_EF1B_N_euk

IPR000433 Znf_ZZ

IPR009060 UBA-like

Graphical View of Domain Structure for InterPro Entry Q14596

ProtoNet protein and cluster: Q14596

3 Blocks protein families:

IPB000270 Octicosapeptide/Phox/Bem1p

IPB000433 Zn-finger

IPB000449 Ubiquitin-associated domain

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596

Domain: The OPR domain mediates interaction with SQSTM1

Similarity: Contains 1 OPR domain

Similarity: Contains 1 UBA domain

Similarity: Contains 1 ZZ-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596

Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

miRNA Products:		OriGene 3'-UTR Clone (see all 3): NBR1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NBR1
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate NBR1 (see all 28):
		hsa-miR-148b* hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-15a hsa-miR-624 hsa-miR-3921 hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: NBR1 3' UTR sequence

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Gene Editing
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NBR1
		Search LifeMap BioReagents cell lines for NBR1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--
GO:0043130	ubiquitin binding	IDA	19427866
GO:0051019	mitogen-activated protein kinase binding	ISS	--

NBR1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for NBR1:

G0/1 arrest

Increased G1 DNA content

Increased HPV18 LCR reporter a

Increased cell size

Animal Models:
5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nbr1):

cellular

hematopoietic system

immune system

limbs/digits/tail

skeleton

NBR1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Cell Signaling Technology (CST) Pathway for NBR1

Apoptosis and Autophagy

NBR1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NBR1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for NBR1 (Q14596^{1, 2, 3} ENSP00000343479⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP1LC3A	Q9H492¹^,²^,³, ENSP00000363970⁴	EBI-2859623,EBI-720768 MINT-7034375 MINT-7034418 MINT-7034400 I2D: score=3 STRING: ENSP00000363970
SQSTM1	Q13501¹^,²^,³, ENSP00000374455⁴	EBI-2859623,EBI-307104 MINT-8075920 I2D: score=6 STRING: ENSP00000374455
USP8	P40818²^,³, ENSP00000302239⁴	MINT-7034470 MINT-7034233 MINT-7034452 I2D: score=1 STRING: ENSP00000302239
VTA1	Q9NP79²^,³, ENSP00000356602⁴	MINT-66288 I2D: score=5 STRING: ENSP00000356602
UBC	P0CG48²^,³, ENSP00000344818⁴	MINT-7034350 MINT-7034309 I2D: score=2 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016236	macroautophagy	IDA	19250911
GO:0030500	regulation of bone mineralization	ISS	--
GO:0032872	regulation of stress-activated MAPK cascade	ISS	--
GO:0045668	negative regulation of osteoblast differentiation	ISS	--
GO:0051259	protein oligomerization	IDA	19250911

NBR1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NBR1
Search CenterWatch for drugs/clinical trials and news about NBR1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NBR1 gene (3 alternative transcripts):

NM_005899.3 NM_031858.2 NM_031862.2

Unigene Cluster for NBR1:

Neighbor of BRCA1 gene 1

Hs.277721 [show with all ESTs]

Unigene Representative Sequence: NM_031858

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341165(uc010whu.2 uc010whv.2 uc010whw.2) ENST00000586650

ENST00000542611(uc010whx.1) ENST00000590996 ENST00000592304 ENST00000589872

ENST00000585505 ENST00000422280(uc010czd.3 uc010diz.3) ENST00000389312

miRNA Products:		OriGene 3'-UTR Clone (see all 3): NBR1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NBR1
		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate NBR1 (see all 28):
		hsa-miR-148b* hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-15a hsa-miR-624 hsa-miR-3921 hsa-miR-374c

		SwitchGear 3'UTR luciferase reporter plasmid: NBR1 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBR1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBR1 (see all 4) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBR1

Additional cDNA sequence:

AF227189.1 AK290005.1 AK297425.1 AK299328.1 AK308324.1 AY450308.1 BC009808.2 BC012591.1

BC012847.1 D30756.1 X76952.1

24/29 DOTS entries (see all 29):

DT.101978440 DT.100822404 DT.102839957 DT.100022668 DT.444984 DT.100822409 DT.101983605 DT.100822401

DT.120910716 DT.100822407 DT.70103187 DT.75164881 DT.91855250 DT.91924762 DT.95105936 DT.100822408

DT.120910734 DT.120910757 DT.120910787 DT.120910809 DT.40245095 DT.95203506 DT.97764832 DT.99938357

24/77 AceView cDNA sequences (see all 77):

BM827388 AL044169 CB160484 AL039232 AW025470 AU140448 AL042510 CF138277

BQ924406 AW236032 BM459691 BF724610 BU161042 CF135984 AF227189 CB988916

AU140463 CB989852 M79023 BM925429 CF138712 AL043920 BU156293 AI091469

GeneLoc Exon Structure

5/17 Alternative Splicing Database (ASD) splice patterns (SP) for NBR1 (see all 17) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13a	·	13b	·	13c	^	14a	·	14b	^	15	^	16a	·	16b	·	16c	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	17	^	18	^	19	^	20	^	21a	·	21b	^	22a	·	22b	^	23a	·	23b	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29a	·	29b
SP1:
SP2:							-		-		-
SP3:			-		-						-
SP4:
SP5:

ECgene alternative splicing isoforms for NBR1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NBR1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

NBR1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/14 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 14)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Dorsal Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Forelimb Ventral Muscles

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Dorsal Muscle

Multinuclear Myocytes

Skeletal Muscle

Limb

Hindlimb Ventral Muscle

Multinuclear Myocytes

Skeletal Muscle

Anterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Cervical Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Back Muscles

Multinuclear Myocytes

Skeletal Muscle

Lumbar Vertebrae Column Muscles

Multinuclear Myocytes

Skeletal Muscle

Pelvic Muscles

Multinuclear Myocytes

Skeletal Muscle

Posterior Neck Muscles

Multinuclear Myocytes

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NBR1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NBR1

SOURCE GeneReport for Unigene cluster: Hs.277721

SABiosciences Custom PCR Arrays for NBR1

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBR1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBR1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NBR1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nbr1^{1 , 5}	neighbor of Brca1 gene 1^{1, 5}	87.01(n)¹ 85.89(a)¹		11 (65.36 cM)⁵ 17966¹ NM_001252220.1¹ NP_001239149.1¹ 101552149⁵
chicken (Gallus gallus)	Aves	NBR1¹	neighbor of BRCA1 gene 1	64.55(n) 64.26(a)		420007 XM_418128.3 XP_418128.3
lizard (Anolis carolinensis)	Reptilia	NBR1⁶	--	54(a)	1 ↔ 1	6(62853766-62874477)
African clawed frog (Xenopus laevis)	Amphibia	BC057740.1²	--	76.26(n)		BC057740.1
zebrafish (Danio rerio)	Actinopterygii	BC057437.1²	--	75.68(n)		BC057437.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G24690⁶	ubiquitin-associated (UBA) zinc-finger and PB1 dom...	15(a)	1 ↔ 1	4(12741033-12744533)
rice (Oryza sativa)	Liliopsida	-- --	joka2, putative, expressed	13(a) 13(a)	many → 1 many → 1	4(23682315-23687167) 2(22975964-22981727)

ENSEMBL Gene Tree for NBR1 (if available)
TreeFam Gene Tree for NBR1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35971878^1,2	C	--	37096814(+)	`GAACC-/TTTTTT`	1	--	int¹		1		NA	2
rs2011316^1,2	H	--	41320563(-)	`ttctcC/Atgcct`	2	--	us2k¹		4		NS EA	418
rs144104613^1,2		--	41320572(+)	`AATCGC/TTTGAA`	2	--	us2k¹		0	--	--	--	--
rs181236128^1,2		--	41320638(+)	`GCAACA/CAGAGC`	2	--	us2k¹		0	--	--	--	--
rs147336599^1,2		--	41320661(+)	`CAAAAA/CTAAAT`	2	--	us2k¹		0	--	--	--	--
rs141018259^1,2		--	41320729(+)	`TAAAGA/GTTCTA`	2	--	us2k¹		0	--	--	--	--
rs76584039^1,2	C,F,	--	41320851(+)	`CTGACC/TGGGTA`	2	--	us2k¹		1		EA	120
rs186268022^1,2		--	41320852(+)	`TGACCA/GGGTAA`	2	--	us2k¹		0	--	--	--	--
rs143030485^1,2		--	41320919(+)	`ATCAAC/GAACGA`	2	--	us2k¹		0	--	--	--	--
rs150820684^1,2		--	41320936(+)	`CAACAC/GCAATC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NBR1 (41322498 - 41363708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NBR1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NBR1 for disorders           About GeneDecksing

OMIM gene information: 166945    OMIM disorders: --

7 diseases for NBR1:    About MalaCards

ovarian cancer ovarian carcinoma carcinoma bilateral breast cancer

breast-ovarian cancer breast cancer retinitis

Human Genome Epidemiology (HuGE) Navigator: NBR1 (1 document)

Export disorders for NBR1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NBR1 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with NBR1)

Utopia: connect your pdf to the dynamic
world of online information

A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PubMed id 8069304)^{1, 2, 3} Campbell I.G....Black D.M. (1994)
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. (PubMed id 19250911)^{1, 2} Kirkin V.... Johansen T. (2009)
Interactions with LC3 and polyubiquitin chains link n br1 to autophagic protein turnover. (PubMed id 19427866)^{1, 2} Waters S....Gautel M. (2009)
The kinase domain of titin controls muscle gene expression and protein turnover. (PubMed id 15802564)^{1, 2} Lange S.... Gautel M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. (PubMed id 12813044)^{1, 2} Lamark T.... Johansen T. (2003)
Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671)^{1, 2} Dimitrov S.... Forejt J. (2001)
Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PubMed id 7581362)^{1, 2} Harshman K.... Kamb A. (1995)
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)^{1, 2} Nomura N....Tabata S. (1994)
Autophagic adapter protein NBR1 is localized in Lewy b odies and glial cytoplasmic inclusions and is involved in aggregate formation in a-synucleinopathy. (PubMed id 22484440)¹ Odagiri S....Wakabayashi K. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4077	HGNC: 6746	AceView: LOC439923	Ensembl:ENSG00000188554	euGenes: HUgn4077
ECgene: NBR1	H-InvDB: NBR1

(According to HUGE)
About This Section

HUGE: KIAA0049

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NBR1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NBR1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NBR1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NBR1 gene:
Search GeneIP for patents involving NBR1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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