Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NBR1 Gene

protein-coding   GIFtS: 59
GCID: GC17P041322

Neighbor Of BRCA1 Gene 1

(Previous names: membrane component, chromosome 17, surface marker 2 (ovarian...)
(Previous symbol: M17S2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Neighbor Of BRCA1 Gene 11 2     Protein 1A1-3B2 3
M17S21 2 3 5     1A1-3B2
Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma
Antigen CA125)1 2
     Migration-Inducing Protein 192
Cell Migration-Inducing Gene 19 Protein2 3     Next To BRCA1 Gene 1 Protein2
Membrane Component Chromosome 17 Surface Marker 22 3     1A13B3
Neighbor Of BRCA1 Gene 1 Protein2 3     KIAA00493

External Ids:    HGNC: 67461   Entrez Gene: 40772   Ensembl: ENSG000001885547   OMIM: 1669455   UniProtKB: Q145963   

Export aliases for NBR1 gene to outside databases

Previous GC identifers: GC17P9L0001 GC17P038578 GC17P037088


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NBR1 Gene:
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian
cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with
transformation potential, but the function of this protein is unknown. This gene is located on a region of
chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced
variants encoding the same protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NBR1 Gene:
NBR1 (neighbor of BRCA1 gene 1) is a protein-coding gene. Diseases associated with NBR1 include bilateral breast cancer, and ovarian cancer. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596
Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

Gene Wiki entry for NBR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NBR1 gene promoter:
         SRF   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NBR1 promoter sequence
   Search Chromatin IP Primers for NBR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NBR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

NBR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P041322:  view genomic region     (about GC identifiers)

Start:
41,322,498 bp from pter      End:
41,363,708 bp from pter
Size:
41,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596 (See protein sequence)
Recommended Name: Next to BRCA1 gene 1 protein  
Size: 966 amino acids; 107413 Da
Subunit: Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN,
RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and
ubiquitinated proteins
Caution: Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125
Sequence caution: Sequence=BAA06417.2; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for NBR1:
1WJ6 (3D)        2BKF (3D)        2CP8 (3D)        2G4S (3D)        2L8J (3D)    
Secondary accessions: Q13173 Q15026 Q5J7Q8 Q96GB6 Q9NRF7
Alternative splicing: 2 isoforms:  Q14596-1   Q14596-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NBR1: NX_Q14596

Explore proteomics data for NBR1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys464, Lys499, Lys515, Lys537, Lys627, Lys887
  • Modification sites at PhosphoSitePlus

  • See NBR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_005890.2  NP_114064.1  NP_114068.1  

    ENSEMBL proteins: 
     ENSP00000343479   ENSP00000466071   ENSP00000437545   ENSP00000466667   ENSP00000467816  
     ENSP00000411250   ENSP00000373963  

    NBR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for NBR1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NBR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NBR1
    GenScript Custom Purified and Recombinant Proteins Services for NBR1
    Novus Biologicals NBR1 Proteins
    Novus Biologicals NBR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NBR1

    NBR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NBR1 
    OriGene Antibodies for NBR1
    OriGene Custom Antibody Services for NBR1
    Novus Biologicals NBR1 Antibodies
    Abcam antibodies for NBR1
    Cloud-Clone Corp. Antibodies for NBR1
    ThermoFisher Antibody for NBR1
    LSBio Antibodies in human, mouse, rat for NBR1

    NBR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NBR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NBR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NBR1
    Cloud-Clone Corp. CLIAs for NBR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR009060 UBA-like
     IPR000270 OPR_PB1
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000433 Znf_ZZ

    Graphical View of Domain Structure for InterPro Entry Q14596

    ProtoNet protein and cluster: Q14596

    3 Blocks protein domains:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000433 Zn-finger
    IPB000449 Ubiquitin-associated domain


    UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596
    Domain: The OPR domain mediates interaction with SQSTM1
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 ZZ-type zinc finger


    NBR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NBR1_HUMAN, Q14596
    Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19250911
    GO:0008270zinc ion binding IEA--
    GO:0043130ubiquitin binding IDA19427866
    GO:0051019mitogen-activated protein kinase binding ISS--
         
    NBR1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NBR1:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a  Increased cell size 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nbr1):
     cellular  hematopoietic system  immune system  limbs/digits/tail  skeleton 

    NBR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NBR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NBR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NBR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NBR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NBR1:
    hsa-mir-92a-3p (MIRT049785), hsa-mir-17-5p (MIRT050957), hsa-mir-615-3p (MIRT039971), hsa-mir-18a-3p (MIRT040928)

    Block miRNA regulation of human, mouse, rat NBR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NBR1 (see all 28):
    hsa-miR-148b* hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-15a hsa-miR-624 hsa-miR-3921 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNBR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NBR1
    Predesigned siRNA for gene silencing in human, mouse, rat NBR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NBR1

    Clone
    Products:
         
    OriGene clones in human, mouse for NBR1 (see all 17)
    OriGene ORF clones in mouse, rat for NBR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NBR1 (NM_031862)
    Sino Biological Human cDNA Clone for NBR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NBR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NBR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NBR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NBR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NBR1_HUMAN, Q14596: Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M
    line (By similarity). Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to
    lysosomes for degradation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    lysosome5
    vacuole5
    endosome4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000407pre-autophagosomal structure IEA--
    GO:0005764lysosome IEA--
    GO:0005770late endosome ISS--
    GO:0005776colocalizes with autophagic vacuole ISS--
    GO:0005829cytosol IDA19250911

    NBR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NBR1
    Interactions:

        GeneGlobe Interaction Network for NBR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NBR1 (Q145961, 2, 3 ENSP000003434794) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4921, 2, 3, ENSP000003639704EBI-742698,EBI-720768 MINT-7034375 MINT-7034418 MINT-7034400 I2D: score=3 STRING: ENSP00000363970
    USP8P408181, 2, 3, ENSP000003022394EBI-742698,EBI-1050865 MINT-7034470 MINT-7034233 MINT-7034452 I2D: score=1 STRING: ENSP00000302239
    SQSTM1Q135011, 2, 3, ENSP000003744554EBI-742698,EBI-307104 MINT-8075920 I2D: score=6 STRING: ENSP00000374455
    VTA1Q9NP792, 3, ENSP000003566024MINT-66288 I2D: score=5 STRING: ENSP00000356602
    UBCP0CG482, 3, ENSP000003448184MINT-7034350 MINT-7034309 I2D: score=2 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016236macroautophagy IDA19250911
    GO:0030500regulation of bone mineralization ISS--
    GO:0032872regulation of stress-activated MAPK cascade ISS--
    GO:0045668negative regulation of osteoblast differentiation ISS--
    GO:0051259protein oligomerization IDA19250911

    NBR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NBR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NBR1 gene (3 alternative transcripts): 
    NM_005899.3  NM_031858.2  NM_031862.2  

    Unigene Cluster for NBR1:

    Neighbor of BRCA1 gene 1
    Hs.277721  [show with all ESTs]
    Unigene Representative Sequence: NM_031858
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000341165(uc010whu.2 uc010whv.2 uc010whw.2) ENST00000586650
    ENST00000542611(uc010whx.1) ENST00000590996 ENST00000592304 ENST00000589872
    ENST00000585505 ENST00000422280(uc010czd.3 uc010diz.3) ENST00000389312

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NBR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NBR1 (see all 28):
    hsa-miR-148b* hsa-miR-3607-3p hsa-miR-429 hsa-miR-300 hsa-miR-15a hsa-miR-624 hsa-miR-3921 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidNBR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NBR1
    Predesigned siRNA for gene silencing in human, mouse, rat NBR1
    Clone
    Products:
         
    OriGene clones in human, mouse for NBR1 (see all 17)
    OriGene ORF clones in mouse, rat for NBR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NBR1 (NM_031862)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NBR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NBR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NBR1
    OriGene qSTAR qPCR primer pairs in human, mouse for NBR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NBR1
      QuantiTect SYBR Green Assays in human, mouse, rat NBR1
      QuantiFast Probe-based Assays in human, mouse, rat NBR1

    Additional mRNA sequence: 

    AF227189.1 AK290005.1 AK297425.1 AK299328.1 AK308324.1 AY450308.1 BC009808.2 BC012591.1 
    BC012847.1 D30756.1 X76952.1 

    Selected DOTS entries (see all 29):

    DT.101978440  DT.100822404  DT.102839957  DT.100022668  DT.444984  DT.100822409  DT.101983605  DT.100822401 
    DT.120910716  DT.100822407  DT.70103187  DT.75164881  DT.91855250  DT.91924762  DT.95105936  DT.100822408 
    DT.120910734  DT.120910757  DT.120910787  DT.120910809  DT.40245095  DT.95203506  DT.97764832  DT.99938357 

    Selected AceView cDNA sequences (see all 77):

    CB160484 AL039232 AF227189 BF724610 CF135984 AW025470 BU161042 AU140448 
    AU140463 CB988916 AW236032 CB989852 BQ924406 CF138277 BM459691 AL042510 
    M79023 AL044169 BM827388 AK128512 BX462113 CD655831 AA486002 BC012591 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NBR1 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                                                                                            
    SP2:                    -     -     -                                                                           
    SP3:        -     -                 -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for NBR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NBR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NBR1 Expression
    About this image


    NBR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Liver (Hepatobiliary System)
    NBR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NBR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.277721
        Custom PCR Arrays for NBR1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NBR1
    OriGene qSTAR qPCR primer pairs in human, mouse for NBR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NBR1
    QuantiTect SYBR Green Assays in human, mouse, rat NBR1
    QuantiFast Probe-based Assays in human, mouse, rat NBR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NBR1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nbr11 , 5 neighbor of Brca1 gene 11, 5 86.42(n)1
    85.06(a)1
      11 (65.36 cM)5
    179661  NM_001252220.11  NP_001239149.11 
     1015521495 
    chicken
    (Gallus gallus)
    Aves NBR11 neighbor of BRCA1 gene 1 64.34(n)
    63.47(a)
      420007  XM_418128.4  XP_418128.4 
    lizard
    (Anolis carolinensis)
    Reptilia NBR16
    neighbor of BRCA1 gene 1
    53(a)
    1 ↔ 1
    6(62853766-62874477)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC057740.12   -- 76.26(n)    BC057740.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC057437.12   -- 75.68(n)    BC057437.1 


    ENSEMBL Gene Tree for NBR1 (if available)
    TreeFam Gene Tree for NBR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NBR1 (see all 745)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20113161,2
    H--41320563(-) ttctcC/Atgcct 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1441046131,2
    --41320572(+) AATCGC/TTTGAA 2 -- us2k10--------
    rs1812361281,2
    --41320638(+) GCAACA/CAGAGC 2 -- us2k10--------
    rs1473365991,2
    --41320661(+) CAAAAA/CTAAAT 2 -- us2k10--------
    rs1410182591,2
    --41320729(+) TAAAGA/GTTCTA 2 -- us2k10--------
    rs765840391,2
    C,F--41320851(+) CTGACC/TGGGTA 2 -- us2k11Minor allele frequency- T:0.05EA 120
    rs1862680221,2
    C--41320852(+) TGACCA/GGGTAA 2 -- us2k10--------
    rs1430304851,2
    --41320919(+) ATCAAC/GAACGA 2 -- us2k10--------
    rs1508206841,2
    --41320936(+) CAACAC/GCAATC 2 -- us2k10--------
    rs1393152191,2
    C--41321015(+) CTGCCA/GGCAGC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NBR1 (41322498 - 41363708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NBR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672913CNV Deletion23128226
    esv2672005CNV Deletion23128226
    nsv510712CNV Loss20534489
    nsv908260CNV Gain21882294
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NBR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NBR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 166945    OMIM disorders: --

    8 diseases for NBR1:    
    About MalaCards
    bilateral breast cancer    ovarian cancer    inclusion body myositis    myositis
    ataxia    retinitis    breast cancer    cervicitis


    NBR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NBR1
    Human Genome Epidemiology (HuGE) Navigator: NBR1 (1 document)

    Export disorders for NBR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NBR1 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with NBR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PubMed id 8069304)1, 2, 3 Campbell I.G....Black D.M. (Hum. Mol. Genet. 1994)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. (PubMed id 19250911)1, 2 Kirkin V.... Johansen T. (Mol. Cell 2009)
    4. Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover. (PubMed id 19427866)1, 2 Waters S.... Gautel M. (FEBS Lett. 2009)
    5. The kinase domain of titin controls muscle gene expression and protein turnover. (PubMed id 15802564)1, 2 Lange S.... Gautel M. (Science 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. (PubMed id 12813044)1, 2 Lamark T.... Johansen T. (J. Biol. Chem. 2003)
    8. Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671)1, 2 Dimitrov S.... Forejt J. (Gene 2001)
    9. Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PubMed id 7581362)1, 2 Harshman K.... Kamb A. (Hum. Mol. Genet. 1995)
    10. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4077 HGNC: 6746 AceView: LOC439923 Ensembl:ENSG00000188554 euGenes: HUgn4077
    ECgene: NBR1 H-InvDB: NBR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0049

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NBR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NBR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NBR1 gene:
    Search GeneIP for patents involving NBR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NBR1   OriGene RNAi products in human, mouse, rat for NBR1  
     OriGene qPCR primer pairs and template standards for NBR1   OriGene Protein Over-expression Lysate for NBR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NBR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NBR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NBR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NBR1   OriGene Custom Protein Services for NBR1  

     
     
     Block miRNA regulation of human, mouse, rat NBR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NBR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NBR1 Predesigned siRNA for gene silencing in human, mouse, rat NBR1
     QuantiFast Probe-based Assays in human, mouse, rat NBR1 QuantiTect SYBR Green Assays in human, mouse, rat NBR1
     Custom PCR Arrays for NBR1 Search Chromatin IP Primers for NBR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NBR1  GeneGlobe Interaction Network for NBR1
     Regulatory tfbs in NBR1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NBR1 GenScript cDNA clones with any tag delivered in your preferred vector for NBR1
     GenScript Custom Assay Services for NBR1 GenScript Custom overexpressing Cell Line Services for NBR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for NBR1 

     Search Tocris compounds for NBR1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NBR1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for NBR1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NBR1 antibodies
     NBR1 proteins
     NBR1 lysates
     Antibodies for NBR1
     See all of Abcam's Antibodies, Kits and Proteins for NBR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NBR1
     Antibodies for NBR1
     ELISAs for NBR1
     CLIAs for NBR1



     Browse ESI BIO Cell Lines and PureStem Progenitors for NBR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBR1
     SwitchGear 3'UTR luciferase reporter plasmids for NBR1
     SwitchGear Promoter luciferase reporter plasmids for NBR1
     ThermoFisher Antibody for NBR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NBR1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NBR1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NBR1
     LSBio Antibodies in human, mouse, rat for NBR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NBR1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4