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Aliases for NBR1 Gene

Aliases for NBR1 Gene

  • Neighbor Of BRCA1 Gene 1 2 3
  • M17S2 3 4 6
  • Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125) 2 3
  • Cell Migration-Inducing Gene 19 Protein 3 4
  • Membrane Component Chromosome 17 Surface Marker 2 4
  • Neighbor Of BRCA1 Gene 1 Protein 4
  • Migration-Inducing Protein 19 3
  • Next To BRCA1 Gene 1 Protein 3
  • Protein 1A1-3B 4
  • B-Box Protein 3
  • KIAA0049 4
  • 1A1-3B 3
  • IAI3B 3
  • MIG19 3
  • 1A13B 4

External Ids for NBR1 Gene

Previous HGNC Symbols for NBR1 Gene

  • M17S2

Previous GeneCards Identifiers for NBR1 Gene

  • GC17P9L0001
  • GC17P038578
  • GC17P041322
  • GC17P037088

Summaries for NBR1 Gene

Entrez Gene Summary for NBR1 Gene

  • The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

GeneCards Summary for NBR1 Gene

NBR1 (Neighbor Of BRCA1 Gene 1) is a Protein Coding gene. Diseases associated with NBR1 include synucleinopathy. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

UniProtKB/Swiss-Prot for NBR1 Gene

  • Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Gene Wiki entry for NBR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBR1 Gene

Genomics for NBR1 Gene

Regulatory Elements for NBR1 Gene

Transcription factor binding sites by QIAGEN in the NBR1 gene promoter:

Genomic Location for NBR1 Gene

43,170,481 bp from pter
43,211,689 bp from pter
41,209 bases
Plus strand

Genomic View for NBR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBR1 Gene

Proteins for NBR1 Gene

  • Protein details for NBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Next to BRCA1 gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • Q13173
    • Q15026
    • Q5J7Q8
    • Q96GB6
    • Q9NRF7

    Protein attributes for NBR1 Gene

    966 amino acids
    Molecular mass:
    107413 Da
    Quaternary structure:
    • Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN, RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and ubiquitinated proteins.
    • Sequence=BAA06417.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NBR1 Gene

    Alternative splice isoforms for NBR1 Gene


neXtProt entry for NBR1 Gene

Proteomics data for NBR1 Gene at MOPED

Post-translational modifications for NBR1 Gene

  • Ubiquitination at Lys464, Lys499, Lys515, Lys537, Lys627, and Lys887
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NBR1 (NBR1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for NBR1

No data available for DME Specific Peptides for NBR1 Gene

Domains for NBR1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q14596
  • The PB1 domain mediates interaction with SQSTM1.
  • Contains 1 PB1 domain.
  • Contains 1 UBA domain.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with NBR1: view

No data available for Gene Families for NBR1 Gene

Function for NBR1 Gene

Molecular function for NBR1 Gene

UniProtKB/Swiss-Prot Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Gene Ontology (GO) - Molecular Function for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250911
GO:0008270 zinc ion binding IEA --
GO:0043130 ubiquitin binding IDA 19427866
GO:0051019 mitogen-activated protein kinase binding ISS --
genes like me logo Genes that share ontologies with NBR1: view
genes like me logo Genes that share phenotypes with NBR1: view

Animal Model Products

CRISPR Products

miRNA for NBR1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NBR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NBR1 Gene

Localization for NBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBR1 Gene

Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M line. Note=In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for NBR1 Gene COMPARTMENTS Subcellular localization image for NBR1 gene
Compartment Confidence
cytosol 5
lysosome 5
vacuole 5
endosome 4
nucleus 3

Gene Ontology (GO) - Cellular Components for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000407 pre-autophagosomal structure IBA --
GO:0005739 colocalizes_with mitochondrion IDA 21296869
GO:0005764 lysosome IEA --
GO:0005770 late endosome ISS --
GO:0005776 colocalizes_with autophagic vacuole ISS --
genes like me logo Genes that share ontologies with NBR1: view

Pathways for NBR1 Gene

SuperPathways for NBR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016236 macroautophagy IDA 19250911
GO:0030500 regulation of bone mineralization ISS --
GO:0032872 regulation of stress-activated MAPK cascade ISS --
GO:0045668 negative regulation of osteoblast differentiation ISS --
GO:0051259 protein oligomerization IDA 19250911
genes like me logo Genes that share ontologies with NBR1: view

No data available for Pathways by source for NBR1 Gene

Transcripts for NBR1 Gene

Unigene Clusters for NBR1 Gene

Neighbor of BRCA1 gene 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NBR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBR1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^
SP11: - -
SP13: - - - -
SP14: - - - - - - -
SP15: - - -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
SP2: - - -
SP3: - - -
SP6: -
SP8: - -
SP9: - -
SP10: - - -
SP12: - -

Relevant External Links for NBR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NBR1 Gene

mRNA expression in normal human tissues for NBR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NBR1 Gene

SOURCE GeneReport for Unigene cluster for NBR1 Gene Hs.277721

genes like me logo Genes that share expressions with NBR1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NBR1 Gene

Orthologs for NBR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NBR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NBR1 35
  • 98.62 (n)
  • 97.93 (a)
NBR1 36
  • 99 (a)
(Bos Taurus)
Mammalia NBR1 35
  • 90.03 (n)
  • 87.97 (a)
NBR1 36
  • 85 (a)
(Canis familiaris)
Mammalia NBR1 35
  • 88.87 (n)
  • 87.61 (a)
NBR1 36
  • 88 (a)
(Mus musculus)
Mammalia Nbr1 35
  • 86.42 (n)
  • 85.06 (a)
Nbr1 16
Nbr1 36
  • 83 (a)
(Monodelphis domestica)
Mammalia NBR1 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NBR1 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Nbr1 35
  • 86.63 (n)
  • 84.61 (a)
(Gallus gallus)
Aves NBR1 35
  • 64.34 (n)
  • 63.47 (a)
NBR1 36
  • 61 (a)
(Anolis carolinensis)
Reptilia NBR1 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nbr1 35
  • 61.48 (n)
  • 53.99 (a)
(Danio rerio)
Actinopterygii LOC555713 35
  • 56.22 (n)
  • 49.47 (a)
nbr1 36
  • 39 (a)
NBR1 (2 of 2) 36
  • 39 (a)
Species with no ortholog for NBR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NBR1 Gene

Gene Tree for NBR1 (if available)
Gene Tree for NBR1 (if available)

Paralogs for NBR1 Gene

No data available for Paralogs for NBR1 Gene

Variants for NBR1 Gene

Sequence variations from dbSNP and Humsavar for NBR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1399323 -- 43,180,313(-) CCTAT(A/G)AGCAA intron-variant
rs1565163 -- 43,209,323(-) TGAGG(C/T)GGGCG intron-variant
rs2271572 -- 43,189,136(-) CCAAG(C/T)GAGAC intron-variant
rs2271573 -- 43,175,604(+) AAACA(A/G)TTCCT intron-variant
rs2271574 -- 43,175,631(+) AAGTT(C/T)CGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NBR1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
esv2672913 CNV Deletion 23128226
esv2672005 CNV Deletion 23128226
nsv908260 CNV Gain 21882294
nsv510712 CNV Loss 20534489

Relevant External Links for NBR1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBR1 Gene

Disorders for NBR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NBR1 Gene including...

Search for NBR1 Gene in MalaCards »

Relevant External Links for NBR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NBR1: view

No data available for UniProtKB/Swiss-Prot for NBR1 Gene

Publications for NBR1 Gene

  1. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PMID: 8069304) Campbell I.G. … Black D.M. (Hum. Mol. Genet. 1994) 2 3 4
  2. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. (PMID: 12813044) Lamark T. … Johansen T. (J. Biol. Chem. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The kinase domain of titin controls muscle gene expression and protein turnover. (PMID: 15802564) Lange S. … Gautel M. (Science 2005) 3 4
  5. Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PMID: 7581362) Harshman K. … Kamb A. (Hum. Mol. Genet. 1995) 3 4

Products for NBR1 Gene

  • Addgene plasmids for NBR1

Sources for NBR1 Gene

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