NBPF4 Gene
protein-coding GIFtS: 37
GCID: GC01M108765
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neuroblastoma breakpoint family, member 4
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Aliases
for NBPF4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuroblastoma Breakpoint Family, Member 41 2 | | FLJ328331 | | Neuroblastoma Breakpoint Family Member 42 |
Export aliases for NBPF4 gene to outside databasesPrevious GC identifers: GC01M108478 GC01M106711 |
Summaries
for NBPF4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NBPF4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NBPF4 gene promoter:
AP-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for NBPF4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBPF4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3NBPF4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M108765: view genomic region
(about GC identifiers)
Start:
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108,765,087 bp from pter |
End:
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108,786,703 bp from pter |
Size:
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21,617 bases |
Orientation:
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minus strand |
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Proteins
for NBPF4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NBPF4_HUMAN, Q96M43 (See
protein sequence)Recommended Name: Neuroblastoma breakpoint family member 4 Size: 638 amino acids; 72053 Da
Subcellular location: Cytoplasm (Probable)
Miscellaneous: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of thechromosome 1
Sequence caution: Sequence=BAB71469.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q5T483Explore the universe of human proteins at neXtProt for NBPF4: NX_Q96M43
NBPF4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001137461.1
ENSEMBL proteins: ENSP00000359055 ENSP00000389237
Human Recombinant Protein Products for NBPF4:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
NBPF4 for ontologies About GeneDecksing
NBPF4 Antibody Products:
Assay Products for NBPF4: |
Protein
Domains /
Families
for NBPF4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NBPF4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96M43ProtoNet protein and cluster: Q96M43 UniProtKB/Swiss-Prot: NBPF4_HUMAN, Q96M43Similarity: Belongs to the NBPF familySimilarity: Contains 3 NBPF domains |
Function
for NBPF4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 GenomeRNAi human phenotype for NBPF4:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NBPF4 (NM_001143989) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NBPF4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF4 |
|
Pathways & Interactions
for NBPF4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NBPF4
|
Drugs & Compounds
for NBPF4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NBPF4
Search CenterWatch for drugs/clinical trials and news about NBPF4
|
Transcripts
for NBPF4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NBPF4 gene (2 alternative transcripts): NM_152488.1 NM_001143989.2 Unigene Cluster for NBPF4: Neuroblastoma breakpoint family, member 4 Hs.511849 [show with all ESTs]Unigene Representative Sequence: NM_0011439893 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487594 ENST00000370038 ENST00000415641(uc009weo.2 uc001dvo.2 uc009wen.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NBPF4 (NM_001143989) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NBPF4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF4 |
Additional cDNA sequence: AK302318.1 AK316438.1 BC125162.1 4 DOTS entries: DT.121451377 DT.121352631 DT.95148305 DT.75150941 2 AceView cDNA sequences: AK057395 NM_152488
GeneLoc Exon Structure
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Expression
for NBPF4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NBPF4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NBPF4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NBPF4
SOURCE GeneReport for Unigene cluster: Hs.511849
UniProtKB/Swiss-Prot: NBPF4_HUMAN, Q96M43Tissue specificity: Expressed in testis
SABiosciences Custom PCR Arrays for NBPF4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NBPF4
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NBPF4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBPF4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBPF4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF4 |
Orthologs
for NBPF4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NBPF4 (if available)
TreeFam Gene Tree for NBPF4 (if available) |
Paralogs
for NBPF4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NBPF4 gene
- NBPF61 2 NBPF32 NBPF202 NBPF82 ENSG000002326372 NBPF162 NBPF92 NBPF112
- NBPF242 NBPF152 NBPF122 NBPF142 NBPF102
18 SIMAP similar genes for NBPF4 using alignment to 2 protein entries: NBPF4_HUMAN (see all proteins):NBPF5 NBPF6 NBPF21 LOC101059961 NBPF20 NBPF3
NBPF7 NBPF12 NBPF24 NBPF10 NBPF9 NBPF15
NBPF16 NBPF8 AL592307.2 NBPF11 NBPF14 NBPF1
NBPF4 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for NBPF4
PGOHUM00000251082 PGOHUM00000251126 PGOHUM00000244972 PGOHUM00000251129 PGOHUM00000250233
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Genomic Variants
for NBPF4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NBPF4 (108765087 - 108786703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NBPF4
3 CNVs: 3305 64539 64536 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NBPF4 |
|
Disorders
/ Diseases
for NBPF4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NBPF4 for disorders About GeneDecksing
OMIM gene information: 613994
OMIM disorders: --
1  disease for NBPF4: About MalaCardsneuroblastoma
Export disorders for NBPF4 gene to outside databases
|
Publications
for NBPF4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NBPF4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NBPF4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PubMed id 16079250)1, 2, 3 Vandepoele K.... van Roy F. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NBPF4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NBPF4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NBPF4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NBPF4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NBPF4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NBPF4 gene:
Search GeneIP for patents involving NBPF4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NBPF4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NBPF4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NBPF4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NBPF4 | | | OriGene Protein Over-expression Lysate for NBPF4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NBPF4 | | OriGene 3'-UTR Clone for NBPF4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NBPF4 | | OriGene Custom Protein Services for NBPF4 | | | OriGene Custom Immunoassay Development | | |
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 | | | NBPF4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NBPF4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF4 |
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