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NBPF3 Gene

protein-coding   GIFtS: 48
GCID: GC01P021766

Neuroblastoma Breakpoint Family, Member 3

  See NBPF3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neuroblastoma Breakpoint Family, Member 31 2
Protein SHIIIa42 3
AE22
Neuroblastoma Breakpoint Family Member 32
Protein AE23

External Ids:    HGNC: 250761   Entrez Gene: 842242   Ensembl: ENSG000001427947   OMIM: 6129925   UniProtKB: Q9H0943   
ORGUL members:         

Export aliases for NBPF3 gene to outside databases

Previous GC identifers: GC01P021512 GC01P021639 GC01P020010


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NBPF3 Gene:
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently
duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has
experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates
in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains.
DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have
been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly,
autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and
urinary tract anomalies. Altered expression of some gene family members is associated with several types of
cancer. This gene family contains numerous pseudogenes. (provided by RefSeq, Feb 2013)

GeneCards Summary for NBPF3 Gene:
NBPF3 (neuroblastoma breakpoint family, member 3) is a protein-coding gene. Diseases associated with NBPF3 include neuroblastoma, and schizophrenia. An important paralog of this gene is NBPF6.

Gene Wiki entry for NBPF3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NBPF3 gene promoter:
         Max1   p53   AP-4   AREB6   CREB   HEN1   deltaCREB   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNBPF3 promoter sequence
   Search Chromatin IP Primers for NBPF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NBPF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

NBPF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBPF3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P021766:  view genomic region     (about GC identifiers)

Start:
21,766,621 bp from pter      End:
21,811,498 bp from pter
Size:
44,878 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NBPF3_HUMAN, Q9H094 (See protein sequence)
Recommended Name: Neuroblastoma breakpoint family member 3  
Size: 633 amino acids; 72951 Da
Miscellaneous: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the
chromosome 1
Sequence caution: Sequence=AAH24011.1; Type=Frameshift; Positions=252; Sequence=CAH72077.1; Type=Erroneous gene
model prediction; Sequence=CAH72078.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K965 B4DSP2 I3L0I8 Q3BBW1 Q5VTG2 Q5VTG3 Q5VTG4 Q8IX78 Q8ND86 Q8TC96
Alternative splicing: 5 isoforms:  Q9H094-1   Q9H094-2   Q9H094-3   Q9H094-4   Q9H094-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NBPF3: NX_Q9H094

Explore proteomics data for NBPF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NBPF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243345.1  NP_001243346.1  NP_115640.1  

    ENSEMBL proteins: 
     ENSP00000316739   ENSP00000340336   ENSP00000391865   ENSP00000415711   ENSP00000316782  

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    antibodies-online proteins for NBPF3 (2 products) 

     
    antibodies-online peptides for NBPF3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NBPF: neuroblastoma breakpoint family

    1 InterPro protein domain:
     IPR010630 NBPF_dom

    Graphical View of Domain Structure for InterPro Entry Q9H094

    ProtoNet protein and cluster: Q9H094

    UniProtKB/Swiss-Prot: NBPF3_HUMAN, Q9H094
    Similarity: Belongs to the NBPF family
    Similarity: Contains 5 NBPF domains


    Find genes that share domains with NBPF3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for NBPF3:
     Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NBPF3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NBPF3_HUMAN, Q9H094: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with NBPF3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NBPF3
    Interactions:

        GeneGlobe Interaction Network for NBPF3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for NBPF3 (Q9H0942, 3 ENSP000003167824) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TSEN15Q8WW013, ENSP000003552994I2D: score=3 STRING: ENSP00000355299
    ANK1P161573, ENSP000002657094I2D: score=1 STRING: ENSP00000265709
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    UBCENSP000003448184STRING: ENSP00000344818
    --Q9BWA23, 2MINT-67372 I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NBPF3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NBPF3 gene (3 alternative transcripts): 
    NM_001256416.2  NM_001256417.2  NM_032264.4  

    Unigene Cluster for NBPF3:

    Neuroblastoma breakpoint family, member 3
    Hs.325422  [show with all ESTs]
    Unigene Representative Sequence: NR_046176
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475869 ENST00000318220(uc001ber.3 uc001bes.3 uc010odm.2)
    ENST00000478653 ENST00000485941 ENST00000342104(uc009vqb.3) ENST00000486229
    ENST00000434838 ENST00000467103 ENST00000469876 ENST00000477050 ENST00000454000
    ENST00000318249
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    Additional mRNA sequence: 

    AF379629.1 AK095602.1 AK098438.1 AK292580.1 AK299840.1 AK314597.1 AL136890.1 AL834330.1 
    AY598326.1 BC024011.2 NR_046176.2 

    17 DOTS entries:

    DT.102844330  DT.100642381  DT.121451686  DT.121451697  DT.121451700  DT.121451706  DT.91661120  DT.95071746 
    DT.121451666  DT.121451691  DT.121451711  DT.121346666  DT.121451670  DT.121451675  DT.121451677  DT.121451710 
    DT.449222 

    Selected AceView cDNA sequences (see all 59):

    BF431439 AI273699 AA768120 AI378933 AY598326 BX339658 AA256559 BG028790 
    NM_032264 AL136890 CB148704 AW401596 BV173019 AV661527 AK095602 BC024011 
    BG028439 CB118666 AI678218 BX418943 AA372620 BE615260 W58508 BI909818 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NBPF3 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^
    SP1:                                                  -     -     -                       -     -                                                               
    SP2:                                                        -     -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                        -     -                                                                                             
    SP5:                                                  -     -                                                                                                   

    ExUns: 12 ^ 13a · 13b · 13c ^ 14 ^ 15
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for NBPF3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NBPF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NBPF3 Expression
    About this image

    NBPF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NBPF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.325422

    UniProtKB/Swiss-Prot: NBPF3_HUMAN, Q9H094
    Tissue specificity: Expressed in testis and fetal heart, as well as in non small cell lung carcinoma and
    neuroblastoma cell line

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of mammals.

    Orthologs for NBPF3 gene from Selected species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    33(a)
    1 → many
    17(57512543-57515264)


    ENSEMBL Gene Tree for NBPF3 (if available)
    TreeFam Gene Tree for NBPF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NBPF3 gene
    NBPF62  NBPF202  NBPF82  ENSG000002038362  NBPF92  NBPF42  NBPF112  NBPF152  
    NBPF12  NBPF142  NBPF102  NBPF122  ENSG000002038272  
    17 SIMAP similar genes for NBPF3 using alignment to 1 protein entry:     NBPF3_HUMAN:
    NBPF21    NBPF14    NBPF24    NBPF1    NBPF10    NBPF11
    NBPF20    NBPF8    NBPF12    NBPF9    AL592307.2    NBPF7
    NBPF15    NBPF16    NBPF5P    NBPF4    NBPF6

    Find genes that share paralogs with NBPF3           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NBPF3
    PGOHUM00000243928


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NBPF3 (see all 1296)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1469448171,2
    --21764708(+) TCAAGC/GAATTC 4 -- us2k10--------
    rs1913614301,2
    --21764942(+) CATGCC/TTCATT 4 -- us2k10--------
    rs752411821,2
    F--21765069(+) AAGTGC/TTCACT 4 -- us2k12Minor allele frequency- T:0.04CSA NA 121
    rs764833321,2
    F--21765147(+) TATTTA/CATCCT 4 -- us2k11Minor allele frequency- C:0.03NA 120
    rs66806281,2
    C,F--21765211(+) gaatgG/Aaaact 4 -- us2k111Minor allele frequency- A:0.32NA WA CSA EA 372
    rs66681411,2
    C,F--21765268(+) TAGGGG/CCTGGG 4 -- us2k111Minor allele frequency- C:0.23NA WA CSA EA 373
    rs66808421,2
    C,F--21765428(+) CCTTCG/AGAAGG 4 -- us2k1 tfbs31Minor allele frequency- A:0.50WA 2
    rs1830641541,2
    --21765500(+) GTGTCA/GCCCAC 4 -- us2k10--------
    rs1149278991,2
    --21765531(+) GAACTA/TCTGTG 4 -- us2k10--------
    rs1142034361,2
    --21765532(+) AACTTA/CTGTGT 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for NBPF3 (21766621 - 21811498 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NBPF3 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661318CNV Deletion23128226
    esv2745042CNV Deletion23290073
    esv2745053CNV Deletion23290073
    esv2456631CNV Deletion19546169
    esv2745064CNV Deletion23290073
    esv1213372CNV Deletion17803354
    esv989724CNV Deletion20482838
    esv2195718CNV Deletion18987734
    esv1311289CNV Deletion17803354
    nsv820559CNV Duplication20802225

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612992    OMIM disorders: --

    2 diseases for NBPF3:    
    About MalaCards
    neuroblastoma    schizophrenia


    Find genes that share disorders with NBPF3           About GenesLikeMe

    Genetic Association Database (GAD): NBPF3

    Export disorders for NBPF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NBPF3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NBPF3)
        Utopia: connect your pdf to the dynamic
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    1. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PubMed id 16079250)1, 2, 3 Vandepoele K.... van Roy F. (Mol. Biol. Evol. 2005)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. (PubMed id 22001757)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2011)
    4. Common genetic variants associate with serum phosphorus concentration. (PubMed id 20558539)1, 4 Kestenbaum B....Fox C.S. (J. Am. Soc. Nephrol. 2010)
    5. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. (PubMed id 19303062)1, 4 Tanaka T....Ferrucci L. (Am. J. Hum. Genet. 2009)
    6. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PubMed id 18940312)1, 4 Yuan X....Mooser V. (Am. J. Hum. Genet. 2008)
    7. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. (PubMed id 15334068)1, 2 Petroziello J.... Carter P. (Oncogene 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84224 HGNC: 25076 AceView: AE2 Ensembl:ENSG00000142794 euGenes: HUgn84224
    ECgene: NBPF3 H-InvDB: NBPF3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NBPF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NBPF3 gene:
    Search GeneIP for patents involving NBPF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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