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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NBPF20 Gene

protein-coding   GIFtS: 29
GCID: GC01M148250          (predicted)

Neuroblastoma Breakpoint Family, Member 20

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neuroblastoma Breakpoint Family, Member 201
LOC1002881422
Neuroblastoma Breakpoint Family Member2

External Ids:    HGNC: 320001   Entrez Gene: 1002881422   Ensembl: ENSG000002038327   OMIM: 6140075   UniProtKB: Q3BBV13   

Export aliases for NBPF20 gene to outside databases

Previous GC identifers: GC01P9K0165 GC01M146616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NBPF20 Gene: 
NBPF20 (neuroblastoma breakpoint family, member 20) is a protein-coding gene. Diseases associated with NBPF20 include neuroblastoma. An important paralog of this gene is NBPF6.

Gene Wiki entry for NBPF20 (NBPF10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NBPF20 gene promoter:
         Max1   AhR   C/EBPbeta   AML1a   GCNF   GATA-1   GCNF-1   c-Myb   GCNF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNBPF20 promoter sequence
   Search SABiosciences Chromatin IP Primers for NBPF20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBPF20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.2   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21.2

NBPF20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBPF20 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M148250:  view genomic region     (about GC identifiers)

Start:
148,250,249 bp from pter      End:
148,347,506 bp from pter
Size:
97,258 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NBPFK_HUMAN, Q3BBV1 (See protein sequence)
Recommended Name: Neuroblastoma breakpoint family member 20  
Size: 942 amino acids; 108576 Da
Subcellular location: Cytoplasm (Probable)
Miscellaneous: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the
chromosome 1

Explore the universe of human proteins at neXtProt for NBPF20: NX_Q3BBV1

Explore proteomics data for NBPF20 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3BBV1

  • NBPF20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NBPF20 Protein Expression
    REFSEQ proteins: NP_001265196.1  
    ENSEMBL proteins: 
     ENSP00000358203   ENSP00000358189   ENSP00000358190   ENSP00000389520  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----

    NBPF20 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NBPF: neuroblastoma breakpoint family

    1 InterPro protein domain:
     IPR010630 NBPF_dom

    Graphical View of Domain Structure for InterPro Entry Q3BBV1

    ProtoNet protein and cluster: Q3BBV1

    UniProtKB/Swiss-Prot: NBPFK_HUMAN, Q3BBV1
    Similarity: Belongs to the NBPF family
    Similarity: Contains 7 NBPF domains


    NBPF20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NBPF20

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NBPF20 (ENSP000003582034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COG8ENSP000003054594STRING: ENSP00000305459
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NBPF20 (NBPFK)

    Search CenterWatch for drugs/clinical trials and news about NBPF20 / NBPFK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for NBPF20 gene: 
    NM_001278267.1  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369202(uc021owf.1 uc001eri.1 uc021owj.1 uc021owp.1 uc021owb.1 uc021owk.1 uc010pan.1 uc021owm.1 uc021owu.1 uc001erg.1 uc001erq.1 uc001eru.1 uc021oww.1 uc021owq.1 uc021owv.1 uc021owg.1 uc021ows.1 uc021owy.1 uc021own.1 uc010paq.2 uc021owz.1 uc001erl.1 uc021owh.1 uc021owl.1 uc021owx.1 uc021oxa.1 uc021owt.1 uc021owr.1 uc001esa.1 uc001erb.3 uc021owo.1 uc001erc.4 uc001erd.4 uc010paj.2)
    ENST00000369188(uc009wkf.1) ENST00000369189(uc010pav.2 uc010paw.2)
    ENST00000414710
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NBPF20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NBPF20 Expression
    About this image


    See NBPF20 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NBPF20
        SABiosciences Custom PCR Arrays for NBPF20
    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for NBPF20 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    37(a)
    possible ortholog
    17(57512543-57515264)


    ENSEMBL Gene Tree for NBPF20 (if available)
    TreeFam Gene Tree for NBPF20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NBPF20 gene
    NBPF62  NBPF32  NBPF82  NBPF162  NBPF92  NBPF42  NBPF112  NBPF242  
    NBPF152  NBPF12  NBPF142  NBPF102  NBPF122  
    18/19 SIMAP similar genes for NBPF20 using alignment to 2 protein entries:     NBPFK_HUMAN (see all proteins) (see all similar genes):
    NBPF21    LOC101059961    NBPF1    NBPF15    NBPF16    NBPF14
    AL592307.2    NBPF8    NBPF24    NBPF9    NBPF10    NBPF8P
    NBPF12    NBPF11    NBPF5P    NBPF7    NBPF3    NBPF6

    NBPF20 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NBPF20
    PGOHUM00000244259 PGOHUM00000244926


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1060 SNPs in NBPF20 are shown (see all 1060)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009574931,2
    F--16974723(+) ATGTTA/CTTCAA 1 -- nc-transcript-variant1Minor allele frequency- C:0.03EU 329
    rs1999776271,2
    F--16974877(+) TTCTGG/TTTAGG 1 -- int11Minor allele frequency- T:0.04EU 167
    rs1995387561,2
    C--16975829(+) ATGGCA/CACTGC 1 -- int10--------
    rs2018802381,2
    C--16976111(+) TTTTTA/CAACAG 1 -- int10--------
    rs2010315951,2
    F--16976321(+) TACAGC/AAGTGC 1 -- nc-transcript-variant1Minor allele frequency- A:0.11EU 131
    rs1899998321,2
    --16976657(+) CAGAAC/GTATGA 1 -- int10--------
    rs2010864891,2
    C--16976671(+) GGACTC/GAAGGG 1 -- int10--------
    rs1997711821,2
    C--16976783(+) CTCCTA/GGAAAT 1 -- int10--------
    rs2016641361,2
    F--16977100(+) AGGACC/GAAGAA 1 -- nc-transcript-variant1Minor allele frequency- G:0.02EU 303
    rs2010992201,2
    F--16979426(+) ATGTTA/CTTCAA 1 -- nc-transcript-variant1Minor allele frequency- C:0.04EU 323

    HapMap Linkage Disequilibrium report for NBPF20 (148250249 - 148347506 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NBPF20: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NBPF20
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614007    OMIM disorders: --

    2 diseases for NBPF20:    About MalaCards
    neuroblastoma    


    NBPF20 for disorders           About GeneDecksing


    Export disorders for NBPF20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed article for NBPF20 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NBPF20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PubMed id 16079250)2, 3 Vandepoele K.... van Roy F. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 100288142 HGNC: 32000 Ensembl:ENSG00000203832 euGenes: HUgn100288142 ECgene: NBPF20
    H-InvDB: NBPF20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NBPF20 gene:
    Search GeneIP for patents involving NBPF20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF20
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NBPF20
     SwitchGear Promoter luciferase reporter plasmids for NBPF20
     Search ThermoFisher Antibodies for NBPF20
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF20
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NBPF20
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NBPF20
    Customized:
     lentivirus for stable overexpression of NBPF20
     lentivirus expression plasmids for stable overexpression of NBPF20
     adenovirus for overexpression of NBPF20
     Search LSBio for Antibodies for NBPF20
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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