Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NBPF15 Gene

Aliases for NBPF15 Gene

  • Neuroblastoma Breakpoint Family Member 15 2 3 5
  • Neuroblastoma Breakpoint Family, Member 16 2 3
  • Neuroblastoma Breakpoint Family, Member 15 2 3
  • Neuroblastoma Breakpoint Family Member 16 3 4
  • NBPF16 3 4
  • AB14 3
  • AG3 3

External Ids for NBPF15 Gene

Previous HGNC Symbols for NBPF15 Gene

  • NBPF16

Previous GeneCards Identifiers for NBPF15 Gene

  • GC01P145341
  • GC01P146827
  • GC01P148555
  • GC01P119791

Summaries for NBPF15 Gene

Entrez Gene Summary for NBPF15 Gene

  • This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, May 2013]

GeneCards Summary for NBPF15 Gene

NBPF15 (Neuroblastoma Breakpoint Family Member 15) is a Protein Coding gene. Diseases associated with NBPF15 include Neuroblastoma. An important paralog of this gene is NBPF14.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBPF15 Gene

Genomics for NBPF15 Gene

Regulatory Elements for NBPF15 Gene

Enhancers for NBPF15 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NBPF15 on UCSC Golden Path with GeneCards custom track

Promoters for NBPF15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NBPF15 on UCSC Golden Path with GeneCards custom track

Genomic Location for NBPF15 Gene

144,421,386 bp from pter
144,461,674 bp from pter
40,289 bases
Minus strand

Genomic View for NBPF15 Gene

Genes around NBPF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBPF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBPF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBPF15 Gene

Proteins for NBPF15 Gene

  • Protein details for NBPF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuroblastoma breakpoint family member 15
    Protein Accession:
    Secondary Accessions:
    • A8MPT6
    • Q3BBV9
    • Q5SXJ2
    • Q8IX77

    Protein attributes for NBPF15 Gene

    670 amino acids
    Molecular mass:
    77563 Da
    Quaternary structure:
    No Data Available
    • Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

neXtProt entry for NBPF15 Gene

Proteomics data for NBPF15 Gene at MOPED

Post-translational modifications for NBPF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NBPF15 Gene

No data available for DME Specific Peptides for NBPF15 Gene

Domains & Families for NBPF15 Gene

Gene Families for NBPF15 Gene

Protein Domains for NBPF15 Gene


Suggested Antigen Peptide Sequences for NBPF15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 NBPF domains.
  • Belongs to the NBPF family.
  • Contains 6 NBPF domains.
  • Belongs to the NBPF family.
genes like me logo Genes that share domains with NBPF15: view

Function for NBPF15 Gene

genes like me logo Genes that share phenotypes with NBPF15: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NBPF15 Gene

Localization for NBPF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBPF15 Gene


No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NBPF15 Gene

Pathways & Interactions for NBPF15 Gene

SuperPathways for NBPF15 Gene

No Data Available

Interacting Proteins for NBPF15 Gene

Gene Ontology (GO) - Biological Process for NBPF15 Gene


No data available for Pathways by source and SIGNOR curated interactions for NBPF15 Gene

Drugs & Compounds for NBPF15 Gene

No Compound Related Data Available

Transcripts for NBPF15 Gene

Unigene Clusters for NBPF15 Gene

Neuroblastoma breakpoint family, member 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NBPF15 Gene

No ASD Table

Relevant External Links for NBPF15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NBPF15 Gene

mRNA expression in normal human tissues for NBPF15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBPF15 Gene

SOURCE GeneReport for Unigene cluster for NBPF15 Gene Hs.656782

mRNA Expression by UniProt/SwissProt for NBPF15 Gene

Tissue specificity: Ubiquitously expressed with a higher expression observed in breast and liver. Also expressed in neuroblastoma cell line.
genes like me logo Genes that share expression patterns with NBPF15: view

Protein tissue co-expression partners for NBPF15 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for NBPF15 Gene

Orthologs for NBPF15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NBPF15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC458021 35
  • 90.69 (n)
  • 83.79 (a)
Species with no ortholog for NBPF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NBPF15 Gene

Gene Tree for NBPF15 (if available)
Gene Tree for NBPF15 (if available)

Paralogs for NBPF15 Gene

(17) SIMAP similar genes for NBPF15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NBPF15: view

Variants for NBPF15 Gene

Sequence variations from dbSNP and Humsavar for NBPF15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6695216 - 144,423,182(-) GACTC(A/C/G/T)GTCAA reference, missense
rs322087 -- 144,460,598(-) CTTTC(A/G)GCAAA intron-variant, upstream-variant-2KB
rs322090 -- 144,461,869(+) TGAAC(A/C/G/T)GCCCC upstream-variant-2KB
rs530834 -- 144,448,626(-) TTGTT(C/G)AACAA intron-variant
rs532582 -- 144,458,693(+) AAAAG(A/G)ATAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NBPF15 Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
dgv117e1 CNV Complex 17122850
esv2750803 CNV Gain 17911159
nsv428235 CNV Gain 18775914
dgv118e1 CNV Complex 17122850
dgv120e1 CNV Complex 17122850
dgv7e55 CNV Loss 17911159
esv2750807 CNV Gain 17911159
esv2717607 CNV Deletion 23290073
dgv122e1 CNV Complex 17122850
nsv872291 CNV Gain 21882294
nsv441713 CNV CNV 18776908
nsv508604 CNV Loss 20534489
esv33539 CNV Gain+Loss 17666407
nsv469683 CNV Loss 16826518
esv27789 CNV Gain 19812545
nsv872292 CNV Gain 21882294
nsv8236 CNV Gain+Loss 18304495
nsv8247 CNV Gain 18304495

Variation tolerance for NBPF15 Gene

Gene Damage Index Score: 0.40; 8.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NBPF15 Gene

Disorders for NBPF15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NBPF15 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NBPF15

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NBPF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBPF15 Gene

Publications for NBPF15 Gene

  1. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PMID: 16079250) Vandepoele K. … van Roy F. (Mol. Biol. Evol. 2005) 2 3 4 67
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  3. Evolutionary history and genome organization of DUF1220 protein domains. (PMID: 22973535) O'Bleness M.S. … Sikela J.M. (G3 (Bethesda) 2012) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for NBPF15 Gene

Sources for NBPF15 Gene