NBPF12 Gene
protein-coding GIFtS: 30
GCID: GC01P146376 (predicted)
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neuroblastoma breakpoint family, member 12(Previous name: KIAA1245 )
(Previous symbol: KIAA1245)
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Aliases
for NBPF12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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| Aliases |
|---|
| Neuroblastoma Breakpoint Family, Member 121 2 | | COAS11 2 3 | | KIAA12451 2 3 | | Chromosome 1 Amplified Sequence 12 3 | | Chomosome One Amplified Sequence 1 Cyclophilin2 | | Neuroblastoma Breakpoint Family Member 122 |
Export aliases for NBPF12 gene to outside databasesPrevious GC identifers: GC01P143685 GC01U901244 GC01M144746 GC01P144927 GC01M146617 |
Summaries
for NBPF12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NBPF12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NBPF12
Other transcription factors
Search SABiosciences Chromatin IP Primers for NBPF12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBPF12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1NBPF12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P146376: view genomic region
(about GC identifiers)
Start:
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146,373,546 bp from pter |
End:
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146,467,744 bp from pter |
Size:
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94,199 bases |
Orientation:
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plus strand |
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Proteins
for NBPF12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: NBPFC_HUMAN, Q5TAG4 (See
protein sequence)Recommended Name: Neuroblastoma breakpoint family member 12 Size: 269 amino acids; 31307 Da
Subcellular location: Cytoplasm (Probable)
Miscellaneous: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of thechromosome 1
Sequence caution: Sequence=CAI22485.1; Type=Erroneous initiation;
Secondary accessions: O95877Explore the universe of human proteins at neXtProt for NBPF12: NX_Q5TAG4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TAG4
NBPF12 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000391116 ENSP00000396525 ENSP00000311131 ENSP00000391949 ENSP00000407570 ENSP00000403340 ENSP00000414845 ENSP00000408372 ENSP00000407863 ENSP00000440069
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005737 | cytoplasm |
IEA | -- |
NBPF12 for ontologies About GeneDecksing
NBPF12 Antibody Products:
Assay Products for NBPF12: |
Protein
Domains /
Families
for NBPF12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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NBPF12 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5TAG4ProtoNet protein and cluster: Q5TAG4 UniProtKB/Swiss-Prot: NBPFC_HUMAN, Q5TAG4Similarity: Belongs to the NBPF familySimilarity: Contains 3 NBPF domains |
Function
for NBPF12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for NBPF12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NBPF12
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Drugs & Compounds
for NBPF12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for NBPF12
Search CenterWatch for drugs/clinical trials and news about NBPF12 / NBPFC 
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Transcripts
for NBPF12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000442909(uc021ovf.1 uc021ovg.1 uc010ozk.1 uc010ozl.2)
ENST00000446760 ENST00000309471 ENST00000439206 ENST00000446080 ENST00000447862
ENST00000438910 ENST00000414957 ENST00000438411 ENST00000537773
GeneLoc Exon Structure
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Expression
for NBPF12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NBPF12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NBPF12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NBPF12
UniProtKB/Swiss-Prot: NBPFC_HUMAN, Q5TAG4Tissue specificity: Widely expressed with highest levels in brain, ovary, mammary gland, skin and adipose tissue. Alsoexpressed in testis. Detected in a number of tumors including osteosarcoma, mammary carcinoma and hepatocellularcarcinoma
SABiosciences Custom PCR Arrays for NBPF12
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NBPF12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBPF12 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBPF12 |
Orthologs
for NBPF12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for NBPF12 (if available)
TreeFam Gene Tree for NBPF12 (if available) |
Paralogs
for NBPF12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NBPF12 gene
- NBPF161 2 NBPF151 2 NBPF91 2 NBPF1 NBPF141 2 NBPF241 2 NBPF111 2 NBPF101 2
- NBPF32 NBPF62 NBPF202 NBPF82 ENSG000002326372 NBPF42
18 SIMAP similar genes for NBPF12 using alignment to 7 protein entries: NBPFC_HUMAN (see all proteins):NBPF21 NBPF11 NBPF8 NBPF20 NBPF1 NBPF14
NBPF15 NBPF16 LOC101059961 NBPF24 AL592307.2 NBPF10
NBPF9 NBPF7 NBPF5 NBPF3 NBPF6 NBPF4
NBPF12 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NBPF12
PGOHUM00000259454
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Genomic Variants
for NBPF12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for NBPF12 (146373546 - 146467744 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NBPF12: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NBPF12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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NBPF12 for disorders About GeneDecksing
OMIM gene information: 608607
OMIM disorders: --
4  diseases for NBPF12: About MalaCardsneuroblastoma hepatocellular carcinoma osteosarcoma carcinoma
Export disorders for NBPF12 gene to outside databases
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Publications
for NBPF12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for NBPF12 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NBPF12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Positional cloning identifies a novel cyclophilin as a candidate amplified oncogene in 1q21. (PubMed id 11948409)1, 2, 3 Meza-Zepeda L.A.... Myklebost O. (2002)
- A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PubMed id 16079250)1, 2 Vandepoele K.... van Roy F. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1 Nagase T.... Ohara O. (1999)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)
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External Searches for NBPF12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NBPF12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing NBPF12 gene
(According to HUGE)
About This Section
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Specialized Databases showing NBPF12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for NBPF12 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for NBPF12 gene:
Search GeneIP for patents involving NBPF12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NBPF12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NBPF12 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NBPF12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBPF12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NBPF12 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBPF12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBPF12 |
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| | | | Search Tocris compounds for NBPF12 |
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 | | | NBPF12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for NBPF12 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF12 |
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