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Aliases for NBPF11 Gene

Aliases for NBPF11 Gene

  • Neuroblastoma Breakpoint Family Member 11 2 3 5
  • Neuroblastoma Breakpoint Family, Member 24 2 3
  • Neuroblastoma Breakpoint Family Member 24 3 4
  • NBPF24 3 4
  • Neuroblastoma Breakpoint Family, Member 11 2

External Ids for NBPF11 Gene

Previous HGNC Symbols for NBPF11 Gene

  • NBPF24

Previous GeneCards Identifiers for NBPF11 Gene

  • GC01M143503
  • GC01M144744
  • GC01M146040
  • GC01M147574

Summaries for NBPF11 Gene

GeneCards Summary for NBPF11 Gene

NBPF11 (Neuroblastoma Breakpoint Family Member 11) is a Protein Coding gene. Diseases associated with NBPF11 include Neuroblastoma. An important paralog of this gene is NBPF12.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBPF11 Gene

Genomics for NBPF11 Gene

Regulatory Elements for NBPF11 Gene


Promoters for NBPF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NBPF11 Gene

Chromosome:
1
Start:
148,102,046 bp from pter
End:
148,152,322 bp from pter
Size:
50,277 bases
Orientation:
Minus strand

Genomic View for NBPF11 Gene

Genes around NBPF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBPF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBPF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBPF11 Gene

Proteins for NBPF11 Gene

  • Protein details for NBPF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T75-NBPFB_HUMAN
    Recommended name:
    Neuroblastoma breakpoint family member 11
    Protein Accession:
    Q86T75
    Secondary Accessions:
    • B1AKG1
    • B7Z7R4
    • Q5RGN0

    Protein attributes for NBPF11 Gene

    Size:
    865 amino acids
    Molecular mass:
    99433 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.
    SequenceCaution:
    • Sequence=CAD89962.1; Type=Frameshift; Positions=498; Evidence={ECO:0000305}; Sequence=CAI17086.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21822.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NBPF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NBPF11 Gene

Post-translational modifications for NBPF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NBPF11 Gene

No data available for DME Specific Peptides for NBPF11 Gene

Domains & Families for NBPF11 Gene

Gene Families for NBPF11 Gene

Protein Domains for NBPF11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBPF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q86T75

UniProtKB/Swiss-Prot:

NBPFB_HUMAN :
  • Contains 6 NBPF domains.
  • Belongs to the NBPF family.
Domain:
  • Contains 6 NBPF domains.
Family:
  • Belongs to the NBPF family.
genes like me logo Genes that share domains with NBPF11: view

Function for NBPF11 Gene

Phenotypes for NBPF11 Gene

GenomeRNAi human phenotypes for NBPF11:
genes like me logo Genes that share phenotypes with NBPF11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NBPF11 Gene

Localization for NBPF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBPF11 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NBPF11 Gene COMPARTMENTS Subcellular localization image for NBPF11 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for NBPF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NBPF11: view

Pathways & Interactions for NBPF11 Gene

SuperPathways for NBPF11 Gene

No Data Available

Interacting Proteins for NBPF11 Gene

Selected Interacting proteins: Q86T75-NBPFB_HUMAN for NBPF11 Gene via IID

Gene Ontology (GO) - Biological Process for NBPF11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NBPF11 Gene

Drugs & Compounds for NBPF11 Gene

No Compound Related Data Available

Transcripts for NBPF11 Gene

mRNA/cDNA for NBPF11 Gene

Unigene Clusters for NBPF11 Gene

Neuroblastoma breakpoint family, member 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBPF11 Gene

No ASD Table

Relevant External Links for NBPF11 Gene

GeneLoc Exon Structure for
NBPF11
ECgene alternative splicing isoforms for
NBPF11

Expression for NBPF11 Gene

mRNA expression in normal human tissues for NBPF11 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBPF11 Gene



Protein tissue co-expression partners for NBPF11 Gene

NURSA nuclear receptor signaling pathways regulating expression of NBPF11 Gene:

NBPF11

SOURCE GeneReport for Unigene cluster for NBPF11 Gene:

Hs.744018

mRNA Expression by UniProt/SwissProt for NBPF11 Gene:

Q86T75-NBPFB_HUMAN
Tissue specificity: Expressed in spinal cord.
genes like me logo Genes that share expression patterns with NBPF11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for NBPF11 Gene

Orthologs for NBPF11 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NBPF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC458021 34
  • 89.72 (n)
  • 83.39 (a)
Species where no ortholog for NBPF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NBPF11 Gene

ENSEMBL:
Gene Tree for NBPF11 (if available)
TreeFam:
Gene Tree for NBPF11 (if available)

Paralogs for NBPF11 Gene

Pseudogenes.org Pseudogenes for NBPF11 Gene

genes like me logo Genes that share paralogs with NBPF11: view

Variants for NBPF11 Gene

Sequence variations from dbSNP and Humsavar for NBPF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs783879 -- 148,153,272(-) GTAGG(A/G)AGGTC upstream-variant-2KB
rs783881 -- 148,153,157(-) ccagg(A/C)agctg upstream-variant-2KB
rs783908 -- 148,139,405(-) GCAGA(C/T)TTCAT intron-variant
rs1058127 -- 148,129,442(-) TGCTG(C/T)TGGGG intron-variant
rs1293691 -- 148,124,919(-) CAGCT(C/G)AAGCA intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NBPF11 Gene

Variant ID Type Subtype PubMed ID
dgv185n106 CNV deletion 24896259
dgv327n100 CNV gain 25217958
dgv46e214 CNV gain 21293372
dgv66e199 CNV deletion 23128226
esv24256 CNV gain 19812545
esv2761299 CNV gain+loss 21179565
nsv1000564 CNV gain 25217958
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1078219 CNV deletion 25765185
nsv1078733 CNV deletion 25765185
nsv1078736 CNV deletion 25765185
nsv1078778 CNV deletion 25765185
nsv1112544 CNV deletion 24896259
nsv1118128 CNV deletion 24896259
nsv1126211 CNV deletion 24896259
nsv1130971 CNV deletion 24896259
nsv1132304 CNV duplication 24896259
nsv482114 CNV gain 20164927
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv511130 CNV loss 21212237
nsv511157 CNV loss 21212237
nsv946319 CNV duplication 23825009
nsv946833 CNV duplication 23825009
nsv946834 CNV duplication 23825009
nsv946835 CNV duplication 23825009
nsv946836 CNV duplication 23825009
nsv946837 CNV duplication 23825009
nsv946838 CNV duplication 23825009
nsv946839 CNV duplication 23825009
nsv946840 CNV duplication 23825009
nsv951823 CNV deletion 24416366
nsv951834 CNV deletion 24416366
nsv951835 CNV deletion 24416366

Variation tolerance for NBPF11 Gene

Gene Damage Index Score: 3.18; 51.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NBPF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NBPF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBPF11 Gene

Disorders for NBPF11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NBPF11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NBPF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NBPF11
genes like me logo Genes that share disorders with NBPF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBPF11 Gene

Publications for NBPF11 Gene

  1. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PMID: 16079250) Vandepoele K. … van Roy F. (Mol. Biol. Evol. 2005) 2 3 4 65
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 65
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3 65

Products for NBPF11 Gene

Sources for NBPF11 Gene

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