NBPF11 Gene
protein-coding GIFtS: 39
GCID: GC01M146040
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|
neuroblastoma breakpoint family, member 11
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Aliases
for NBPF11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Neuroblastoma Breakpoint Family, Member 111 2 | | Neuroblastoma Breakpoint Family Member 112 |
Export aliases for NBPF11 gene to outside databasesPrevious GC identifers: GC01M143503 GC01M144744 GC01M147574 |
Summaries
for NBPF11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NBPF11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167185.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NBPF11 gene promoter:
AhR p53 AML1a HTF RelA NF-kappaB C/EBPalpha AREB6 CHOP-10 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NBPF11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBPF11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.1 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1NBPF11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M146040: view genomic region
(about GC identifiers)
Start:
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146,032,542 bp from pter |
End:
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146,082,765 bp from pter |
Size:
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50,224 bases |
Orientation:
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minus strand |
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Proteins
for NBPF11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NBPFB_HUMAN, Q86T75 (See
protein sequence)Recommended Name: Neuroblastoma breakpoint family member 11 Size: 865 amino acids; 99433 Da
Subcellular location: Cytoplasm (Probable)
Miscellaneous: Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of thechromosome 1
Sequence caution: Sequence=CAD89962.1; Type=Frameshift; Positions=498; Sequence=CAI17086.2; Type=Erroneous gene modelprediction; Sequence=CAI21822.2; Type=Erroneous gene model prediction;
Secondary accessions: B1AKG1 B7Z7R4Alternative splicing: 2 isoforms: Q86T75-1 Q86T75-2 Explore the universe of human proteins at neXtProt for NBPF11: NX_Q86T75
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86T75
NBPF11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_899228.4
ENSEMBL proteins: ENSP00000418802 ENSP00000383795 ENSP00000345181 ENSP00000358329 ENSP00000383794
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
-- | -- |
NBPF11 for ontologies About GeneDecksing
NBPF11 Antibody Products:
Assay Products for NBPF11: |
Protein
Domains /
Families
for NBPF11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NBPF11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86T75ProtoNet protein and cluster: Q86T75 UniProtKB/Swiss-Prot: NBPFB_HUMAN, Q86T75Similarity: Belongs to the NBPF familySimilarity: Contains 6 NBPF domains |
Function
for NBPF11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF11
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NBPF11 (NM_183372) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NBPF11 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF11 |
|
Pathways & Interactions
for NBPF11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NBPF11
|
Drugs & Compounds
for NBPF11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NBPF11
Search CenterWatch for drugs/clinical trials and news about NBPF11 / NBPFB
|
Transcripts
for NBPF11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NBPF11 gene: NM_183372.4 Unigene Cluster for NBPF11: Neuroblastoma breakpoint family, member 11 Hs.744018 [show with all ESTs]Unigene Representative Sequence: NM_1833725 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479926 ENST00000401010 ENST00000339388(uc001eox.3 uc010ozg.2 uc009wjc.3 uc001eoy.3 uc001eoz.3 uc010ozh.2 uc001epa.3)
ENST00000369323 ENST00000401009
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF11
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NBPF11 (NM_183372) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NBPF11 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF11 |
Additional cDNA sequence: BX648497.1 24/42 DOTS entries (see all 42): DT.95301339 DT.100058829 DT.97861525 DT.91787194 DT.91983631 DT.92411509 DT.95239666 DT.121460365 DT.121460586 DT.87078282 DT.95247186 DT.100646648 DT.100650944 DT.121406339 DT.99963054 DT.87017630 DT.121406403 DT.433627 DT.100713385 DT.121406382 DT.100826929 DT.121406315 DT.121406317 DT.121406326 24/36 AceView cDNA sequences (see all 36): BX955185 BX280681 BG391131 BF897012 AW749186 AW160820 BM835771 BX496243 AY032616 BG480547 BX456385 AL041003 BE818276 BG059741 BE731777 BG990103 AW903264 BI039676 CK001817 BU658923 BU521010 AW934860 BI192970 CB143514
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NBPF11 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for NBPF11
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Expression
for NBPF11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NBPF11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NBPF11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NBPF11
SOURCE GeneReport for Unigene cluster: Hs.744018
UniProtKB/Swiss-Prot: NBPFB_HUMAN, Q86T75Tissue specificity: Expressed in spinal cord
SABiosciences Custom PCR Arrays for NBPF11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NBPF11
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NBPF11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBPF11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBPF11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF11 |
Orthologs
for NBPF11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NBPF11 (if available)
TreeFam Gene Tree for NBPF11 (if available) |
Paralogs
for NBPF11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NBPF11 gene
- NBPF241 2 NBPF1 NBPF91 2 NBPF121 2 NBPF141 2 NBPF161 2 NBPF151 2 NBPF101 2
- NBPF32 NBPF62 NBPF202 NBPF82 ENSG000002326372 NBPF42
18 SIMAP similar genes for NBPF11 using alignment to 5 protein entries: NBPFB_HUMAN (see all proteins):NBPF21 NBPF24 NBPF12 NBPF20 LOC101059961 NBPF1
NBPF15 NBPF16 NBPF8 NBPF14 NBPF10 AL592307.2
NBPF9 NBPF7 NBPF5 NBPF3 NBPF6 NBPF4
NBPF11 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for NBPF11
PGOHUM00000259453 PGOHUM00000259822 PGOHUM00000263266
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Genomic Variants
for NBPF11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NBPF11 (146032542 - 146082765 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for NBPF11
15/17 CNVs (see all 17): 31655 84533 74687 69953 74686 84534 69925 30421 3312 5520 84535 84524 74688 69924 69952
1 Inversion: 29494 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NBPF11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NBPF11 for disorders About GeneDecksing
OMIM gene information: 614001
OMIM disorders: --
1  disease for NBPF11: About MalaCardsneuroblastoma
Export disorders for NBPF11 gene to outside databases
|
Publications
for NBPF11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NBPF11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NBPF11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PubMed id 16079250)1, 2, 3 Vandepoele K.... van Roy F. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Chibby interacts with NBPF1 and clusterin, two candid ate tumor suppressors linked to neuroblastoma. (PubMed id 20096688)1 Vandepoele K....van Roy F. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Constitutional translocation t(1;17)(p36.31-p36.13;q11.2-q12.1) in a neuroblastoma patient. Establishment of somatic cell hybrids and identification of PND/A12M2 on chromosome 1 and NF1/SCYA7 on chromosome 17 as breakpoint flanking single copy markers. (PubMed id 7700633)1 Laureys G.... Van Roy N. (1995)
|
External Searches for NBPF11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NBPF11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NBPF11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NBPF11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NBPF11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NBPF11 gene:
Search GeneIP for patents involving NBPF11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NBPF11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NBPF11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NBPF11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NBPF11 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for NBPF11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NBPF11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NBPF11 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NBPF11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBPF11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NBPF11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBPF11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBPF11 |
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| | | | Search Tocris compounds for NBPF11 |
| |  |  |  |  | | | | |
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 | | | NBPF11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBPF11 |
|  |  |  | | | | Search ThermoFisher Antibodies for NBPF11 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NBPF11 |
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