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Aliases for NBPF10 Gene

Aliases for NBPF10 Gene

  • Neuroblastoma Breakpoint Family Member 10 2 3 5
  • Neuroblastoma Breakpoint Family, Member 10 2
  • NBPF9 3
  • AB6 3
  • AG1 3

External Ids for NBPF10 Gene

Previous GeneCards Identifiers for NBPF10 Gene

  • GC01P142784
  • GC01M016761
  • GC01P144001
  • GC01P145293
  • GC01M120910
  • GC01P145294
  • GC01P145297

Summaries for NBPF10 Gene

Entrez Gene Summary for NBPF10 Gene

  • This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for NBPF10 Gene

NBPF10 (Neuroblastoma Breakpoint Family Member 10) is a Protein Coding gene. Diseases associated with NBPF10 include Neuroblastoma. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is NBPF19.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBPF10 Gene

Genomics for NBPF10 Gene

Regulatory Elements for NBPF10 Gene

Enhancers for NBPF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F146209 1.5 FANTOM5 Ensembl ENCODE 6.3 -67.3 -67259 5.2 ZNF146 RNF2 JUN ZNF318 ZNF316 SMARCA4 PRDM10 EMSY MAFK NOTCH2NL NBPF10 PIR33330 PIR39582
GH01F146241 1.6 FANTOM5 Ensembl ENCODE 4.6 -97.1 -97059 1.2 ZNF316 PKNOX1 ZNF585B PBX2 ZNF143 NFE2 EMSY NOTCH2NL NBPF10 LOC105371254 LOC105371249
GH01F146248 1.5 FANTOM5 Ensembl 4.1 -103.2 -103160 1.8 KLF1 TAL1 CEBPB DPF2 ARID1B ZBTB48 NBN FOS ZNF600 PRDM1 NOTCH2NL NBPF10 LOC105371254 LOC105371249
GH01F145976 1 FANTOM5 ENCODE 2.8 +163.0 162957 10.0 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 YY1 POLR3C ANKRD35 NOTCH2NL HFE2 RBM8A LIX1L-AS1 PEX11B GNRHR2 LIX1L TXNIP
GH01F145793 0.5 FANTOM5 2 +351.0 350972 0.4 PDZK1 NBPF10 PIR40983 PIR35710
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NBPF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for NBPF10 Gene

Chromosome:
1
Start:
146,064,699 bp from pter
End:
146,144,942 bp from pter
Size:
80,244 bases
Orientation:
Minus strand

Genomic View for NBPF10 Gene

Genes around NBPF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBPF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBPF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBPF10 Gene

Proteins for NBPF10 Gene

  • Protein details for NBPF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3W6-NBPFA_HUMAN
    Recommended name:
    Neuroblastoma breakpoint family member 10
    Protein Accession:
    Q6P3W6
    Secondary Accessions:
    • Q5RHC0
    • Q9NWN6

    Protein attributes for NBPF10 Gene

    Size:
    841 amino acids
    Molecular mass:
    96426 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Alternative splice isoforms for NBPF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NBPF10 Gene

Post-translational modifications for NBPF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NBPF10 Gene

Domains & Families for NBPF10 Gene

Gene Families for NBPF10 Gene

Protein Domains for NBPF10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBPF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3W6

UniProtKB/Swiss-Prot:

NBPFA_HUMAN :
  • Contains 6 NBPF domains.
  • Belongs to the NBPF family.
Domain:
  • Contains 6 NBPF domains.
Family:
  • Belongs to the NBPF family.
genes like me logo Genes that share domains with NBPF10: view

Function for NBPF10 Gene

Gene Ontology (GO) - Molecular Function for NBPF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with NBPF10: view

Phenotypes for NBPF10 Gene

GenomeRNAi human phenotypes for NBPF10:
genes like me logo Genes that share phenotypes with NBPF10: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NBPF10 Gene

Localization for NBPF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBPF10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NBPF10 Gene COMPARTMENTS Subcellular localization image for NBPF10 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NBPF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NBPF10: view

Pathways & Interactions for NBPF10 Gene

SuperPathways for NBPF10 Gene

No Data Available

Interacting Proteins for NBPF10 Gene

Gene Ontology (GO) - Biological Process for NBPF10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NBPF10 Gene

Transcripts for NBPF10 Gene

mRNA/cDNA for NBPF10 Gene

(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NBPF10 Gene

No ASD Table

Relevant External Links for NBPF10 Gene

GeneLoc Exon Structure for
NBPF10
ECgene alternative splicing isoforms for
NBPF10

Expression for NBPF10 Gene

mRNA expression in normal human tissues for NBPF10 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBPF10 Gene



Protein tissue co-expression partners for NBPF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NBPF10 Gene:

NBPF10
genes like me logo Genes that share expression patterns with NBPF10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NBPF10 Gene

Orthologs for NBPF10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NBPF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC458021 34
  • 85.69 (n)
Species where no ortholog for NBPF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NBPF10 Gene

ENSEMBL:
Gene Tree for NBPF10 (if available)
TreeFam:
Gene Tree for NBPF10 (if available)

Paralogs for NBPF10 Gene

Variants for NBPF10 Gene

Sequence variations from dbSNP and Humsavar for NBPF10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10158162 -- 146,139,022(-) tggaa(C/T)acctg intron-variant
rs1043495 -- 146,066,155(+) TGTGC(A/G)CAGTC downstream-variant-500B
rs1043765 -- 146,066,307(+) CCTTA(A/C/G/T)TAATC downstream-variant-500B
rs10533520 -- 146,139,281(-) AATAC(-/AA)AAAAA intron-variant
rs10752816 -- 146,144,187(-) CCCAA(C/G)AGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NBPF10 Gene

Variant ID Type Subtype PubMed ID
dgv18n82 CNV duplication 23825009
dgv327n100 CNV gain 25217958
dgv3n6 CNV deletion 16902084
dgv66e199 CNV deletion 23128226
esv2248028 CNV deletion 18987734
esv2667344 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv3540411 CNV deletion 23714750
esv3571119 CNV gain 25503493
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1075385 CNV duplication 25765185
nsv1075794 CNV duplication 25765185
nsv1076340 CNV duplication 25765185
nsv1076341 CNV duplication 25765185
nsv1076778 CNV deletion 25765185
nsv1077298 CNV duplication 25765185
nsv1077299 CNV duplication 25765185
nsv1110138 CNV duplication 24896259
nsv1118449 CNV duplication 24896259
nsv1118450 CNV duplication 24896259
nsv1124582 CNV duplication 24896259
nsv1128614 CNV duplication 24896259
nsv1132306 CNV duplication 24896259
nsv1132307 CNV duplication 24896259
nsv1132308 CNV duplication 24896259
nsv1132309 CNV duplication 24896259
nsv1146139 CNV duplication 26484159
nsv1148915 CNV duplication 26484159
nsv1151944 CNV duplication 26484159
nsv13 CNV deletion 15895083
nsv160210 CNV deletion 16902084
nsv160417 CNV deletion 16902084
nsv24 CNV insertion 15895083
nsv2677 CNV deletion 18451855
nsv2688 CNV insertion 18451855
nsv433348 CNV gain 18776910
nsv508582 CNV deletion 20534489
nsv509457 CNV insertion 20534489
nsv8091 CNV gain 18304495
nsv831337 CNV loss 17160897
nsv831348 CNV loss 17160897
nsv831359 CNV loss 17160897
nsv946760 CNV duplication 23825009
nsv946761 CNV duplication 23825009
nsv946762 CNV duplication 23825009
nsv946763 CNV duplication 23825009
nsv946764 CNV duplication 23825009
nsv946765 CNV duplication 23825009
nsv946766 CNV duplication 23825009
nsv946767 CNV duplication 23825009
nsv946768 CNV duplication 23825009
nsv946769 CNV duplication 23825009
nsv946770 CNV duplication 23825009
nsv946771 CNV duplication 23825009
nsv946772 CNV duplication 23825009
nsv946774 CNV duplication 23825009
nsv946775 CNV duplication 23825009
nsv946777 CNV duplication 23825009
nsv946778 CNV duplication 23825009
nsv946779 CNV duplication 23825009
nsv946780 CNV duplication 23825009
nsv946781 CNV duplication 23825009
nsv946782 CNV duplication 23825009
nsv946783 CNV duplication 23825009
nsv946785 CNV duplication 23825009
nsv946786 CNV duplication 23825009
nsv946787 CNV duplication 23825009
nsv946788 CNV duplication 23825009
nsv946789 CNV duplication 23825009
nsv946790 CNV duplication 23825009
nsv946791 CNV duplication 23825009
nsv946792 CNV duplication 23825009
nsv946793 CNV duplication 23825009
nsv946794 CNV duplication 23825009
nsv946795 CNV duplication 23825009
nsv946796 CNV duplication 23825009
nsv946797 CNV duplication 23825009
nsv946798 CNV duplication 23825009
nsv946799 CNV duplication 23825009
nsv946800 CNV duplication 23825009
nsv946801 CNV duplication 23825009
nsv946802 CNV duplication 23825009
nsv946803 CNV duplication 23825009
nsv946804 CNV duplication 23825009
nsv946807 CNV duplication 23825009
nsv946808 CNV duplication 23825009
nsv946813 CNV duplication 23825009
nsv946814 CNV duplication 23825009
nsv946815 CNV duplication 23825009
nsv946817 CNV duplication 23825009
nsv946818 CNV duplication 23825009
nsv946819 CNV duplication 23825009
nsv946846 CNV duplication 23825009
nsv946993 CNV duplication 23825009
nsv950946 CNV duplication 24416366
nsv952720 CNV deletion 24416366
nsv957530 CNV deletion 24416366

Variation tolerance for NBPF10 Gene

Gene Damage Index Score: 7.82; 83.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NBPF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NBPF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBPF10 Gene

Disorders for NBPF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NBPF10 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NBPF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NBPF10
genes like me logo Genes that share disorders with NBPF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBPF10 Gene

Publications for NBPF10 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PMID: 16079250) Vandepoele K. … van Roy F. (Mol. Biol. Evol. 2005) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. (PMID: 24395524) Natrajan R. … Reis-Filho J.S. (J. Pathol. 2014) 3 64

Products for NBPF10 Gene

Sources for NBPF10 Gene

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