Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NBPF10 Gene

Aliases for NBPF10 Gene

  • Neuroblastoma Breakpoint Family Member 10 2 3 5
  • Neuroblastoma Breakpoint Family, Member 10 2 3
  • NBPF9 3
  • AB6 3
  • AG1 3

External Ids for NBPF10 Gene

Previous GeneCards Identifiers for NBPF10 Gene

  • GC01P142784
  • GC01M016761
  • GC01P144001
  • GC01P145293
  • GC01M120910
  • GC01P145294
  • GC01P145297

Summaries for NBPF10 Gene

Entrez Gene Summary for NBPF10 Gene

  • This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

GeneCards Summary for NBPF10 Gene

NBPF10 (Neuroblastoma Breakpoint Family Member 10) is a Protein Coding gene. Diseases associated with NBPF10 include neuroblastoma and separation anxiety disorder. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is NBPF14.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBPF10 Gene

Genomics for NBPF10 Gene

Regulatory Elements for NBPF10 Gene

Genomic Location for NBPF10 Gene

Chromosome:
1
Start:
146,064,699 bp from pter
End:
146,144,942 bp from pter
Size:
80,244 bases
Orientation:
Minus strand

Genomic View for NBPF10 Gene

Genes around NBPF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NBPF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NBPF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBPF10 Gene

Proteins for NBPF10 Gene

  • Protein details for NBPF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P3W6-NBPFA_HUMAN
    Recommended name:
    Neuroblastoma breakpoint family member 10
    Protein Accession:
    Q6P3W6
    Secondary Accessions:
    • Q5RHC0
    • Q9NWN6

    Protein attributes for NBPF10 Gene

    Size:
    841 amino acids
    Molecular mass:
    96426 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Encoded by one of the numerous copies of NBPF genes clustered in the p36, p12 and q21 region of the chromosome 1.

    Alternative splice isoforms for NBPF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NBPF10 Gene

Proteomics data for NBPF10 Gene at MOPED

Post-translational modifications for NBPF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NBPF10 Gene

Domains & Families for NBPF10 Gene

Gene Families for NBPF10 Gene

Protein Domains for NBPF10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NBPF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P3W6

UniProtKB/Swiss-Prot:

NBPFA_HUMAN :
  • Contains 6 NBPF domains.
  • Belongs to the NBPF family.
Domain:
  • Contains 6 NBPF domains.
Family:
  • Belongs to the NBPF family.
genes like me logo Genes that share domains with NBPF10: view

Function for NBPF10 Gene

Phenotypes for NBPF10 Gene

GenomeRNAi human phenotypes for NBPF10:
genes like me logo Genes that share phenotypes with NBPF10: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NBPF10 Gene

Localization for NBPF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBPF10 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NBPF10 Gene COMPARTMENTS Subcellular localization image for NBPF10 gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NBPF10 Gene

Pathways & Interactions for NBPF10 Gene

SuperPathways for NBPF10 Gene

No Data Available

Interacting Proteins for NBPF10 Gene

Gene Ontology (GO) - Biological Process for NBPF10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NBPF10 Gene

Drugs & Compounds for NBPF10 Gene

No Compound Related Data Available

Transcripts for NBPF10 Gene

mRNA/cDNA for NBPF10 Gene

(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NBPF10 Gene

No ASD Table

Relevant External Links for NBPF10 Gene

GeneLoc Exon Structure for
NBPF10
ECgene alternative splicing isoforms for
NBPF10

Expression for NBPF10 Gene

mRNA expression in normal human tissues for NBPF10 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NBPF10 Gene



genes like me logo Genes that share expression patterns with NBPF10: view

Protein tissue co-expression partners for NBPF10 Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NBPF10 Gene

Orthologs for NBPF10 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for NBPF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC458021 35
  • 85.69 (n)
  • 76.8 (a)
Species with no ortholog for NBPF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NBPF10 Gene

ENSEMBL:
Gene Tree for NBPF10 (if available)
TreeFam:
Gene Tree for NBPF10 (if available)

Paralogs for NBPF10 Gene

genes like me logo Genes that share paralogs with NBPF10: view

Variants for NBPF10 Gene

Sequence variations from dbSNP and Humsavar for NBPF10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs389679 -- 146,128,531(+) CCCAG(A/C)CTCTC intron-variant
rs320828 -- 146,131,059(-) gcaac(A/C)cctgc intron-variant
rs557407 -- 146,131,591(+) aaact(A/C/G)aacaa intron-variant
rs561293 -- 146,139,604(-) agcct(A/G)cacaa intron-variant
rs561294 -- 146,139,603(-) gccta(C/G)acaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NBPF10 Gene

Variant ID Type Subtype PubMed ID
nsv428212 CNV Gain 18775914
nsv872203 CNV Gain 21882294
dgv104e1 CNV Complex 17122850
nsv7181 OTHER Inversion 18451855
esv2717206 CNV Deletion 23290073
dgv66e199 CNV Deletion 23128226
dgv15n16 CNV Deletion 17901297
dgv46e201 CNV Deletion 23290073
nsv509457 CNV Insertion 20534489
dgv105e1 CNV Complex 17122850
dgv108e1 CNV Complex 17122850
dgv111e1 CNV Complex 17122850
esv27127 CNV Gain 19812545
nsv824442 CNV Gain 20364138
nsv8091 CNV Gain 18304495
nsv831337 CNV Loss 17160897
nsv831348 CNV Loss 17160897
esv2422428 CNV Duplication 17116639
nsv2677 CNV Loss 18451855
nsv508582 CNV Loss 20534489
nsv831359 CNV Loss 17160897
nsv435814 CNV Deletion 17901297
nsv433348 CNV Gain 18776910
nsv872223 CNV Gain 21882294
esv2717407 CNV Deletion 23290073
esv2667344 CNV Deletion 23128226
nsv498688 CNV Loss 21111241
nsv511125 CNV Loss 21212237
nsv13 CNV Loss 15895083
essv16633 CNV CNV 17122850
dgv112e1 CNV Complex 17122850
nsv24 CNV Insertion 15895083
nsv2688 CNV Insertion 18451855
esv2248028 CNV Deletion 18987734
dgv3n6 CNV Loss 16902084
nsv160210 CNV Loss 16902084
nsv160417 CNV Loss 16902084

Variation tolerance for NBPF10 Gene

Gene Damage Index Score: 7.82; 83.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NBPF10 Gene

HapMap Linkage Disequilibrium report
NBPF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NBPF10 Gene

Disorders for NBPF10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NBPF10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
separation anxiety disorder
  • separation anxiety disorder of childhood
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NBPF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NBPF10
genes like me logo Genes that share disorders with NBPF10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NBPF10 Gene

Publications for NBPF10 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. (PMID: 16079250) Vandepoele K. … van Roy F. (Mol. Biol. Evol. 2005) 2 3
  3. Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast. (PMID: 24395524) Natrajan R. … Reis-Filho J.S. (J. Pathol. 2014) 3
  4. Bioinformatics analysis reveals disturbance mechanism of MAPK signaling pathway and cell cycle in Glioblastoma multiforme. (PMID: 24967941) Li W. … Zou H. (Gene 2014) 3
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3

Products for NBPF10 Gene

Sources for NBPF10 Gene

Back to Top

Content