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NBL1 Gene

protein-coding   GIFtS: 54
GCID: GC01P019968

Neuroblastoma 1, DAN Family BMP Antagonist

(Previous names: neuroblastoma, suppression of tumorigenicity 1)
  See NBL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuroblastoma 1, DAN Family BMP Antagonist1 2     Neuroblastoma, Suppression Of Tumorigenicity 11
DAN2 3 5     Suppression Of Tumorigenicity 11
Differential Screening-Selected Gene Aberrant In Neuroblastoma1 2     NB2
Neuroblastoma Suppressor Of Tumorigenicity 11 2     NO32
DAND12 3     Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 12
DAN Domain Family Member 12 3     Protein N033
D1S1733E2 5     Zinc Finger Protein DAN3
Neuroblastoma Candidate Region1     

External Ids:    HGNC: 76501   Entrez Gene: 46812   Ensembl: ENSG000001587477   OMIM: 6006135   UniProtKB: P412713   

Export aliases for NBL1 gene to outside databases

Previous GC identifers: GC01P019530 GC01P018995 GC01P019115 GC01P019439 GC01P019715 GC01P019842 GC01P018215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NBL1 Gene:
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of
proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of
signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by
binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role
during growth and development. Alternatively spliced transcript variants have been identified for this gene.
Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1
gene (GeneID 440574) have been observed. (provided by RefSeq, May 2013)

GeneCards Summary for NBL1 Gene:
NBL1 (neuroblastoma 1, DAN family BMP antagonist) is a protein-coding gene. Diseases associated with NBL1 include neuroblastoma 1, and neuroblastoma. GO annotations related to this gene include morphogen activity and BMP binding. An important paralog of this gene is MINOS1-NBL1.

UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
Function: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing
cells from entering the final stage (G1/S) of the transformation process




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NBL1 gene promoter:
         p53   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNBL1 promoter sequence
   Search Chromatin IP Primers for NBL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.3-p36.2

NBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P019968:  view genomic region     (about GC identifiers)

Start:
19,967,048 bp from pter      End:
19,984,949 bp from pter
Size:
17,902 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271 (See protein sequence)
Recommended Name: Neuroblastoma suppressor of tumorigenicity 1 precursor  
Size: 180 amino acids; 19277 Da
Subunit: Homodimer (By similarity)
Sequence caution: Sequence=AAL15440.1; Type=Erroneous initiation; Sequence=BAF82145.1; Type=Erroneous initiation;
Sequence=BAF84790.1; Type=Erroneous initiation; Sequence=CAI19019.1; Type=Erroneous initiation;
Sequence=EAW94894.1; Type=Erroneous initiation;
Secondary accessions: A3KFI7 Q5TGZ2 Q5U0N4 Q96L68
Alternative splicing: 2 isoforms:  P41271-1   P41271-2   

Explore the universe of human proteins at neXtProt for NBL1: NX_P41271

Explore proteomics data for NBL1 at MOPED


See NBL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (8 alternative transcripts): 
NP_001191013.1  NP_001191014.1  NP_001191015.1  NP_001265093.1  NP_001265094.1  NP_001265095.1  NP_005371.2  NP_877421.2  

ENSEMBL proteins: 
 ENSP00000412419   ENSP00000289749   ENSP00000390607   ENSP00000399333   ENSP00000364278  
 ENSP00000400250   ENSP00000391858   ENSP00000394079   ENSP00000449007  

NBL1 Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for NBL1
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Novus Biologicals NBL1 Proteins
Novus Biologicals NBL1 Lysates
Sino Biological Recombinant Protein for NBL1
Sino Biological Cell Lysate for NBL1
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Cloud-Clone Corp. Proteins for NBL1

 
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antibodies-online proteins for NBL1 (9 products) 

 
antibodies-online peptides for NBL1

NBL1 Antibody Products:

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Abcam antibodies for NBL1
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ThermoFisher Antibodies for NBL1
antibodies-online antibodies for NBL1 (39 products) 

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antibodies-online kits for NBL1 (18 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR016728 Neuroblast_suppress_tumour_1
 IPR006207 Cys_knot_C
 IPR004133 DAN

Graphical View of Domain Structure for InterPro Entry P41271

ProtoNet protein and cluster: P41271

1 Blocks protein domain: IPB004133 DAN domain

UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
Similarity: Belongs to the DAN family
Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


Find genes that share domains with NBL1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NBL1_HUMAN, P41271
Function: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing
cells from entering the final stage (G1/S) of the transformation process

     Genatlas biochemistry entry for NBL1:
neuroblastoma,suppression of tumorigenicity 1 (see TSG1A,CDC2L1,CDC2L2,CDC2L3)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016015morphogen activity ISS--
GO:0036122BMP binding ISS--
GO:0042803protein homodimerization activity IMP--
     
Find genes that share ontologies with NBL1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for NBL1:
 Decreased viability with carbo 

     4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nbl1):
 behavior/neurological  integument  normal  skeleton 

Find genes that share phenotypes with NBL1           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for NBL1: Nbl1tm1Saki Nbl1tm1Rmh

   genOway: Develop your customized and physiologically relevant rodent model for NBL1

miRNA
Products:
    
miRTarBase miRNAs that target NBL1:
hsa-mir-1 (MIRT024064), hsa-mir-7-5p (MIRT025945), hsa-mir-124-3p (MIRT023164)

Block miRNA regulation of human, mouse, rat NBL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NBL1 (see all 32):
hsa-miR-4291 hsa-miR-345 hsa-miR-136 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidNBL1 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for NBL1
Predesigned siRNA for gene silencing in human, mouse, rat NBL1

Gene Editing
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DNA2.0 Custom Protein Engineering Service for NBL1

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OriGene clones in human, mouse for NBL1 (see all 13)
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GenScript: all cDNA clones in your preferred vector (see all 5): NBL1 (NM_182744)
Sino Biological Human cDNA Clone for NBL1
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NBL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NBL1

Cell Line
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GenScript Custom overexpressing Cell Line Services for NBL1
Browse ESI BIO Cell Lines and PureStem Progenitors for NBL1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBL1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NBL1_HUMAN, P41271: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
mitochondrion2
nucleus1
plasma membrane1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005615extracellular space IC--

Find genes that share ontologies with NBL1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NBL1 About    
See pathways by source

SuperPathContained pathways About
1TGF-beta Signaling Pathway (sino)
TGF-beta Signaling Pathway


1 Sino Biological Pathway for NBL1
    TGF-beta Signaling Pathway


    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NBL1
Interactions:

    GeneGlobe Interaction Network for NBL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NBL1 (P412713 ENSP000002897494) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
InteractantInteraction Details
GeneCardExternal ID(s)
BAG6P463793, ENSP000003651314I2D: score=2 STRING: ENSP00000365131
ENSG00000096155P463793I2D: score=2 
ENSG00000227761P463793I2D: score=2 
ENSG00000228760P463793I2D: score=2 
ENSG00000229524P463793I2D: score=2 
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Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007399nervous system development ISS--
GO:0030514negative regulation of BMP signaling pathway IDA--
GO:0035582sequestering of BMP in extracellular matrix ISS--
GO:0038098sequestering of BMP from receptor via BMP binding IDA--
GO:0045666positive regulation of neuron differentiation ISS--

Find genes that share ontologies with NBL1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NBL1



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NBL1 gene (8 alternative transcripts): 
NM_001204084.2  NM_001204085.1  NM_001204086.2  NM_001278164.1  NM_001278165.1  NM_001278166.1  NM_005380.7  NM_182744.3  

Unigene Cluster for NBL1:

Neuroblastoma 1, DAN family BMP antagonist
Hs.654502  [show with all ESTs]
Unigene Representative Sequence: NM_001204088
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000428975 ENST00000289749 ENST00000451758 ENST00000439664 ENST00000375136(uc001bck.2)
ENST00000425400 ENST00000439278 ENST00000427894 ENST00000548815(uc021ohw.1 uc009vpl.2 uc001bcj.2 uc009vpm.2 uc021ohy.1 uc021ohz.1)

miRNA
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Block miRNA regulation of human, mouse, rat NBL1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate NBL1 (see all 32):
hsa-miR-4291 hsa-miR-345 hsa-miR-136 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-761
SwitchGear 3'UTR luciferase reporter plasmidNBL1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NBL1
Predesigned siRNA for gene silencing in human, mouse, rat NBL1
Clone
Products:
     
OriGene clones in human, mouse for NBL1 (see all 13)
OriGene ORF clones in mouse, rat for NBL1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): NBL1 (NM_182744)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NBL1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NBL1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NBL1
OriGene qSTAR qPCR primer pairs in human, mouse for NBL1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NBL1
  QuantiTect SYBR Green Assays in human, mouse, rat NBL1
  QuantiFast Probe-based Assays in human, mouse, rat NBL1

Additional mRNA sequence: 

AK292101.1 AK300872.1 AK309257.1 AK313265.1 AY049783.1 BC012037.1 BT019423.1 D28124.1 

15 DOTS entries:

DT.448044  DT.99973574  DT.100000996  DT.121421071  DT.100789144  DT.121421098  DT.121421160  DT.91757247 
DT.121421005  DT.121421189  DT.91757246  DT.95366333  DT.95366334  DT.95366340  DT.121420911 

Selected AceView cDNA sequences (see all 683):

AA653270 BM664212 T31861 BQ446175 CK822440 NM_005380 AI198180 BQ948819 
BQ723152 CB162365 BM737839 AA843137 AI459426 BF725493 CA436821 AI087950 
BM974841 BM829746 CR598310 BM474063 AW270725 AA598830 BM504924 CA435607 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for NBL1 (see all 9)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1:                    -     -     -     -     -     -                                             
SP2:              -     -     -     -     -     -     -                                             
SP3:                          -     -     -     -     -                                             
SP4:        -     -     -     -     -     -     -     -                                             
SP5:                                -     -     -     -                                             


ECgene alternative splicing isoforms for NBL1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NBL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AATAAATTCC
NBL1 Expression
About this image


NBL1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 16) fully expand
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Meningeal Fibroblasts Anterior Pia Mater
         Medulla Oblongata
 
 Limb (Muscoskeletal System)    fully expand to see all 3 entries
         Zeugopod
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
         Muscle Progenitor Cells Mandibular Arch Muscles
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Head Mesenchyme (Muscoskeletal System)
         Dental Mesenchymal Cells Branchial Arch 1
NBL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NBL1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654502

UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
Tissue specificity: Most abundant in normal lung and meningioma

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QuantiFast Probe-based Assays in human, mouse, rat NBL1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBL1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NBL1 gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Nbl11 , 5 neuroblastoma, suppression of tumorigenicity 11, 5 89.51(n)1
93.82(a)1
  4 (70.57 cM)5
179651  NM_008675.21  NP_032701.21 
 1390822845 
chicken
(Gallus gallus)
Aves NBL11 neuroblastoma, suppression of tumorigenicity 1 79.31(n)
79.19(a)
  373952  NM_204149.1  NP_989480.1 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
63(a)
1 → many
GL344078.1(38851-58076)
African clawed frog
(Xenopus laevis)
Amphibia nbl1-A-prov2 neuroblastoma, suppression of tumorigenicity 1 83.14(n)    AF045797.1 
zebrafish
(Danio rerio)
Actinopterygii nbl11 neuroblastoma, suppression of tumorigenicity 1 69.39(n)
68.71(a)
  404629  NM_207097.1  NP_996980.1 


ENSEMBL Gene Tree for NBL1 (if available)
TreeFam Gene Tree for NBL1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NBL1 gene
MINOS1-NBL11 2  
2 SIMAP similar genes for NBL1 using alignment to 7 protein entries:     NBL1_HUMAN (see all proteins):
MINOS1-NBL1    GREM2

Find genes that share paralogs with NBL1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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10 SNPs for NBL1    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs360303801,2
C--19975841(+) TTATTATT/-TTGAG 1 -- cds11Minor allele frequency- -:0.00NA 2
rs357303411,2
C--19977784(+) CAGCGC/-CCTGC 1 -- int12Minor allele frequency- -:0.00NA CSA 4
rs38384301,2
C--19978954(+) GGGGG-/GCAGCC 1 -- int10--------
rs106315311,2
C--19979778(+) gtctcAA/-aaaaa 1 -- int1 trp31Minor allele frequency- -:0.50NA 2
rs609481011,2
C--19979799(+) AAAAA-/A/AAA 
        
GTACC
2 -- int1 cds11NA 2
rs359890271,2
C--19983863(+) TTTTT-/GGGGGGG 1 -- ut310--------
rs38335421,2
C--19983871(+) GGGGG-/G/G   
   G
/GGG
TGGTC
3 -- ut31 cds11NA 2
rs114305841,2
C--19984100(+) TCCGGC/-CCCAC 1 -- ut311Minor allele frequency- -:0.00NA 2
rs668456201,2
----19979800(+) AAAAG-/A/AAA 
        
TACCT
2 -- int1 cds10--------
rs3731111471,2
----18215941(+) GGCTGA/TGTCTA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for NBL1 (19967048 - 19984949 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for NBL1:    About this table    
Variant IDTypeSubtypePubMed ID
esv2395760CNV Deletion18987734
nsv508991CNV Insertion20534489
dgv187n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600613    OMIM disorders: --

3 diseases for NBL1:    
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neuroblastoma 1    neuroblastoma    meningioma


Find genes that share disorders with NBL1           About GenesLikeMe


Export disorders for NBL1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NBL1 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with NBL1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus. (PubMed id 8084583)1, 2, 9 Enomoto H....Sakiyama S. (Oncogene 1994)
  2. Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium. (PubMed id 11594460)1, 2, 9 Ahmed A.... Parenteau N. (J. Protein Chem. 2001)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. (PubMed id 7633401)1, 3 Caron H....Westerveld A. (Hum. Mol. Genet. 1995)
  5. Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. (PubMed id 21743959)1 Shaikhibrahim Z....Wernert N. (Int. J. Mol. Med. 2011)
  6. NBL1 and anillin (ANLN) genes over-expression in pancreatic carcinoma. (PubMed id 19995712)1 Olakowski M....Jarzab B. (Folia Histochem. Cytobiol. 2009)
  7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  9. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. (PubMed id 15528323)1 Chen B....Yang D. (J. Immunol. 2004)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4681 HGNC: 7650 AceView: NBL1 Ensembl:ENSG00000158747 euGenes: HUgn4681
ECgene: NBL1 H-InvDB: NBL1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NBL1 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NBL1 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NBL1 gene:
Search GeneIP for patents involving NBL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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