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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NBL1 Gene

protein-coding   GIFtS: 55
GCID: GC01P019968

neuroblastoma 1, DAN family BMP antagonist

(Previous names: neuroblastoma, suppression of tumorigenicity 1 )
 Explore 14 diseases affiliated with
NBL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NBL1    

Aliases
for NBL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neuroblastoma 1, DAN Family BMP Antagonist1 2     DAN Domain Family Member 12 3
DAN1 2 3 5     Differential Screening-Selected Gene Aberrant In Neuroblastoma2
DAND11 2 3     Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 12
D1S1733E1 2 5     Neuroblastoma Suppressor Of Tumorigenicity 12
NB1 2     Protein N033
NO31 2     Zinc Finger Protein DAN3
Neuroblastoma, Suppression Of Tumorigenicity 11 2     

External Ids:    HGNC: 76501   Entrez Gene: 46812   Ensembl: ENSG000001587477   OMIM: 6006135   UniProtKB: P412713   

Export aliases for NBL1 gene to outside databases

Previous GC identifers: GC01P019530 GC01P018995 GC01P019115 GC01P019439 GC01P019715 GC01P019842 GC01P018215


Summaries
for NBL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NBL1:
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins,
which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling
molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and
preventing them from interacting with their receptors. They may thus play an important role during growth and
development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts
between this locus and the upstream chromosome 1 open reading frame 151 locus (GeneID 440574) have been
observed.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
Function: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing
cells from entering the final stage (G1/S) of the transformation process




Genomic Views
for NBL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NBL1 gene promoter:
         p53   NF-kappaB1   NF-kappaB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NBL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NBL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NBL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.3-p36.2

NBL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P019968:  view genomic region     (about GC identifiers)

Start:
 19,967,048 bp from pter      End:
 19,984,945 bp from pter
Size:
 17,898 bases      Orientation:
 plus strand

Proteins
for NBL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271 (See protein sequence)
Recommended Name: Neuroblastoma suppressor of tumorigenicity 1 precursor  
Size: 180 amino acids; 19277 Da
Subcellular location: Secreted
Sequence caution: Sequence=AAL15440.1; Type=Erroneous initiation; Sequence=BAF82145.1; Type=Erroneous initiation;
Sequence=BAF84790.1; Type=Erroneous initiation; Sequence=CAI19019.1; Type=Erroneous initiation; Sequence=EAW94894.1;
Type=Erroneous initiation;
Secondary accessions: A3KFI7 Q5TGZ2 Q5U0N4 Q96L68
Alternative splicing: 2 isoforms:  P41271-1   P41271-2   

Explore the universe of human proteins at neXtProt for NBL1: NX_P41271

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41271

    • NBL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001191013.1  NP_001191014.1  NP_001191015.1  NP_005371.2  NP_877421.2  

    ENSEMBL proteins: 
     ENSP00000412419   ENSP00000289749   ENSP00000390607   ENSP00000399333   ENSP00000364278  
     ENSP00000400250   ENSP00000391858   ENSP00000394079   ENSP00000449007  

    Human Recombinant Protein Products: 
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    Novus Biologicals NBL1 Proteins
    Novus Biologicals NBL1 Lysates
    Sino Biological Recombinant Protein for NBL1
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NBL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--


    NBL1 for ontologies           About GeneDecksing



    NBL1 Antibody Products: 
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    ThermoFisher Antibodies for NBL1

    Assay Products for NBL1: 
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    Uscn ELISAs and CLIAs for NBL1

    Protein Domains /
    Families
    for NBL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NBL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016728 Neuroblast_suppress_tumour_1
     IPR006207 Cys_knot_C
     IPR004133 DAN

    Graphical View of Domain Structure for InterPro Entry P41271

    ProtoNet protein and cluster: P41271

    1 Blocks protein family: IPB004133 DAN domain

    UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
    Similarity: Belongs to the DAN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


    Function
    for NBL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
    Function: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing
    cells from entering the final stage (G1/S) of the transformation process

         Genatlas biochemistry entry for NBL1:
    neuroblastoma,suppression of tumorigenicity 1 (see TSG1A,CDC2L1,CDC2L2,CDC2L3)

    miRNA
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    hsa-miR-4291 hsa-miR-345 hsa-miR-136 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: NBL1 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: NBL1
    OriGene siRNA: NBL1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NBL1

    Clone
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    Sino Biological Human cDNA Clone for NBL1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NBL1 

    Cell Line
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    Search LifeMap BioReagents cell lines for NBL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBL1

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016015morphogen activity ISS--
    GO:0036122BMP binding ISS--


    NBL1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NBL1:
     Decreased viability with carbo 

    Animal Models:
         Mouse knock-outs for NBL1: Nbl1tm1Saki Nbl1tm1Rmh
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nbl1):
     behavior/neurological  integument  normal  skeleton 

    NBL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NBL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NBL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/26 Interacting proteins for NBL1 (P412713 ENSP000002897494) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463793, ENSP000003651314I2D: score=2 STRING: ENSP00000365131
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    UBQLN1Q9UMX03, ENSP000003655764I2D: score=2 STRING: ENSP00000365576
    C1orf194ENSP000003589654STRING: ENSP00000358965
    ESPNENSP000003670594STRING: ENSP00000367059
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007399nervous system development ISS--
    GO:0035582sequestering of BMP in extracellular matrix ISS--
    GO:0045666positive regulation of neuron differentiation ISS--
    GO:0048263determination of dorsal identity ISS--
    GO:0048812neuron projection morphogenesis ISS--


    NBL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NBL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NBL1
    Search CenterWatch for drugs/clinical trials and news about NBL1 

    Transcripts
    for NBL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NBL1 gene (5 alternative transcripts): 
    NM_001204084.2  NM_001204085.1  NM_001204086.2  NM_005380.6  NM_182744.3  

    Unigene Cluster for NBL1:

    Neuroblastoma, suppression of tumorigenicity 1
    Hs.654502  [show with all ESTs]
    Unigene Representative Sequence: NM_001204088
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000428975 ENST00000289749 ENST00000451758 ENST00000439664 ENST00000375136(uc001bck.2)
    ENST00000425400 ENST00000439278 ENST00000427894 ENST00000548815(uc021ohw.1 uc009vpl.2 uc001bcj.2 uc009vpm.2 uc021ohy.1 uc021ohz.1)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NBL1
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate NBL1 (see all 32):
    hsa-miR-4291 hsa-miR-345 hsa-miR-136 hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-526b* hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmid: NBL1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NBL1 (see all 7)
    OriGene shRNA RFP: NBL1
    OriGene siRNA: NBL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NBL1
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 5): NBL1 (NM_182744)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NBL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NBL1

    Additional cDNA sequence: 

    AK292101.1 AK300872.1 AK309257.1 AK313265.1 AY049783.1 BC012037.1 BT019423.1 D28124.1 

    15 DOTS entries:

    DT.448044  DT.99973574  DT.100000996  DT.121421071  DT.100789144  DT.121421098  DT.121421160  DT.91757247 
    DT.121421005  DT.121421189  DT.91757246  DT.95366333  DT.95366334  DT.95366340  DT.121420911 

    24/683 AceView cDNA sequences (see all 683):

    BM504598 BM923803 BU624114 BX473700 BG057665 AA962155 AI927268 AI291388 
    AI160894 BQ224585 BP343642 AW085641 BM737839 CB162365 BQ723152 BF724246 
    BM793234 AI005016 BQ948819 AA314855 CB157536 BC009927 AI475505 AI268816 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NBL1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:                    -     -     -     -     -     -                                             
    SP2:              -     -     -     -     -     -     -                                             
    SP3:                          -     -     -     -     -                                             
    SP4:        -     -     -     -     -     -     -     -                                             
    SP5:                                -     -     -     -                                             


    ECgene alternative splicing isoforms for NBL1

    Expression
    for NBL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NBL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAATTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NBL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainAnterior Pia MaterMeningeal FibroblastsMeninges
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    LimbAutopodLimb
    LimbStylopodLimb
    LimbZeugopodLimb
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NBL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NBL1

    SOURCE GeneReport for Unigene cluster: Hs.654502

    UniProtKB/Swiss-Prot: NBL1_HUMAN, P41271
    Tissue specificity: Most abundant in normal lung and meningioma

        SABiosciences Custom PCR Arrays for NBL1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NBL1

    Orthologs
    for NBL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NBL1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NBL11 neuroblastoma, suppression of tumorigenicity 1 79.5(n)
    79.77(a)    		   373952  NM_204149.1  NP_989480.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NBL16
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL344078.1(41893-46457)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nbl1-A-prov2 neuroblastoma, suppression of tumorigenicity 1 83.14(n)    AF045797.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nbl11 neuroblastoma, suppression of tumorigenicity 1 70.97(n)
    70.32(a)    		   404629  NM_207097.1  NP_996980.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 15(a)
    		 1 ↔ 1
    		 Group14.3(813012-814283)


    ENSEMBL Gene Tree for NBL1 (if available)
    TreeFam Gene Tree for NBL1 (if available) 

    Paralogs
    for NBL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NBL1 gene
    C1orf151-NBL1  GREM12  GREM22  
    2 SIMAP similar genes for NBL1 using alignment to 7 protein entries:     NBL1_HUMAN (see all proteins):
    GREM2    GREM1

    NBL1 for paralogs           About GeneDecksing



    Genomic Variants
    for NBL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/323 NCBI SNPs in NBL1 are shown (see all 323)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120864181,2
    		--19967780(+) TAGATA/GTTACT 3 -- us2k1 int12Minor allele frequency- G:0.11CSA WA 120
    rs1451738521,2
    		--19967781(+) AGATAC/TTACTA 3 -- int1 us2k10--------
    rs1149539741,2
    		F,--19967830(+) TTCCCG/ATCACC 3 -- us2k1 int11Minor allele frequency- A:0.09WA 118
    rs1158491911,2
    		F,--19967878(+) GATTAG/TGGGGT 3 -- int1 us2k11Minor allele frequency- T:0.09WA 118
    rs1835987461,2
    		--19967881(+) TAGGGG/TGTTGG 3 -- int1 us2k10--------
    rs1491475721,2
    		--19967886(+) GGTTGG/TTGTTG 3 -- us2k1 int10--------
    rs726560781,2
    		C,--19967905(+) CCTCCC/TGGTGT 3 -- int1 us2k11Minor allele frequency- T:0.01NA 120
    rs1145373581,2
    		--19967906(+) CTCCCG/AGTGTT 3 -- us2k1 int11Minor allele frequency- A:0.01WA 118
    rs2007003121,2
    		C--19967963(-) GAGTAA/GAAGCC 3 -- us2k1 int10--------
    rs124086631,2
    		C,F,H,--19968058(+) AACTCT/CACTTT 3 -- us2k1 int116Minor allele frequency- C:0.32NS EA NA 2104

    HapMap Linkage Disequilibrium report for NBL1 (19967048 - 19984945 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NBL1: --

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    Disorders / Diseases
    for NBL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NBL1 for disorders           About GeneDecksing

    OMIM gene information: 600613    OMIM disorders: --

    14 diseases for NBL1:    About MalaCards
    neuroblastoma    anal canal carcinoma    pancoast tumor    bladder carcinoma in situ
    osteomalacia    hypercalcemia    lung meningioma    bladder carcinoma
    meningioma    osteoporosis    prostate cancer    carcinoma
    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NBL1:
    Bladder carcinoma in situ

    Export disorders for NBL1 gene to outside databases

    Publications
    for NBL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NBL1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with NBL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus. (PubMed id 8084583)1, 2, 9 Enomoto H....Sakiyama S. (1994)
    2. Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium. (PubMed id 11594460)1, 2, 9 Ahmed A.... Parenteau N. (2001)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. (PubMed id 7633401)1, 3 Caron H....Westerveld A. (1995)
    5. Analysis of laser-microdissected prostate cancer tiss ues reveals potential tumor markers. (PubMed id 21743959)1 Shaikhibrahim Z....Wernert N. (2011)
    6. NBL1 and anillin (ANLN) genes over-expression in panc reatic carcinoma. (PubMed id 19995712)1 Olakowski M....Jarzab B. (2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    9. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. (PubMed id 15528323)1 Chen B....Yang D. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    External Searches for NBL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NBL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4681 HGNC: 7650 AceView: NBL1 Ensembl:ENSG00000158747 euGenes: HUgn4681
    ECgene: NBL1 H-InvDB: NBL1

    Other Databases showing NBL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NBL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NBL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NBL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NBL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NBL1 gene:
    Search GeneIP for patents involving NBL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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