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Aliases for NBL1 Gene

Aliases for NBL1 Gene

  • Neuroblastoma 1, DAN Family BMP Antagonist 2 3
  • DAN 3 4 6
  • Differential Screening-Selected Gene Aberrant In Neuroblastoma 2 3
  • Neuroblastoma Suppressor Of Tumorigenicity 1 2 3
  • DAN Domain Family Member 1 3 4
  • D1S1733E 3 6
  • DAND1 3 4
  • Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 1 3
  • Neuroblastoma, Suppression Of Tumorigenicity 1 2
  • Suppression Of Tumorigenicity 1 2
  • Neuroblastoma Candidate Region 2
  • Zinc Finger Protein DAN 4
  • Protein N03 4
  • NO3 3
  • NB 3

External Ids for NBL1 Gene

Previous GeneCards Identifiers for NBL1 Gene

  • GC01P019530
  • GC01P018995
  • GC01P019115
  • GC01P019439
  • GC01P019715
  • GC01P019842
  • GC01P019968
  • GC01P018215

Summaries for NBL1 Gene

Entrez Gene Summary for NBL1 Gene

  • This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

GeneCards Summary for NBL1 Gene

NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist) is a Protein Coding gene. Diseases associated with NBL1 include neuroblastoma. Among its related pathways are TGF-beta Signaling Pathway (sino). GO annotations related to this gene include morphogen activity and BMP binding. An important paralog of this gene is MINOS1-NBL1.

UniProtKB/Swiss-Prot for NBL1 Gene

  • Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NBL1 Gene

Genomics for NBL1 Gene

Regulatory Elements for NBL1 Gene

Genomic Location for NBL1 Gene

Start:
19,640,554 bp from pter
End:
19,658,456 bp from pter
Size:
17,903 bases
Orientation:
Plus strand

Genomic View for NBL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NBL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NBL1 Gene

Proteins for NBL1 Gene

  • Protein details for NBL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41271-NBL1_HUMAN
    Recommended name:
    Neuroblastoma suppressor of tumorigenicity 1
    Protein Accession:
    P41271
    Secondary Accessions:
    • A3KFI7
    • Q5TGZ2
    • Q5U0N4
    • Q96L68

    Protein attributes for NBL1 Gene

    Size:
    181 amino acids
    Molecular mass:
    19408 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAH12037.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA05671.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92265.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36074.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NBL1 Gene

    Alternative splice isoforms for NBL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NBL1 Gene

Proteomics data for NBL1 Gene at MOPED

Post-translational modifications for NBL1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NBL1 Gene

Domains for NBL1 Gene

Protein Domains for NBL1 Gene

Suggested Antigen Peptide Sequences for NBL1 Gene

Graphical View of Domain Structure for InterPro Entry

P41271

UniProtKB/Swiss-Prot:

NBL1_HUMAN :
  • P41271
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
Family:
  • Belongs to the DAN family.
genes like me logo Genes that share domains with NBL1: view

No data available for Gene Families for NBL1 Gene

Function for NBL1 Gene

Molecular function for NBL1 Gene

GENATLAS Biochemistry: neuroblastoma,suppression of tumorigenicity 1 (see TSG1A,CDC2L1,CDC2L2,CDC2L3)
UniProtKB/Swiss-Prot Function: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process

Gene Ontology (GO) - Molecular Function for NBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0016015 morphogen activity ISS --
GO:0036122 BMP binding ISS --
GO:0042803 protein homodimerization activity IMP 23063586
genes like me logo Genes that share ontologies with NBL1: view

Phenotypes for NBL1 Gene

genes like me logo Genes that share phenotypes with NBL1: view

Animal Models for NBL1 Gene

MGI Knock Outs for NBL1:

miRNA for NBL1 Gene

miRTarBase miRNAs that target NBL1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NBL1 Gene

Localization for NBL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NBL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NBL1 Gene COMPARTMENTS Subcellular localization image for NBL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IC 23063586
genes like me logo Genes that share ontologies with NBL1: view

Pathways for NBL1 Gene

SuperPathways for NBL1 Gene

genes like me logo Genes that share pathways with NBL1: view

Pathways by source for NBL1 Gene

1 Sino Biological pathway for NBL1 Gene

Gene Ontology (GO) - Biological Process for NBL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development ISS --
GO:0030514 negative regulation of BMP signaling pathway IDA 23063586
GO:0035582 sequestering of BMP in extracellular matrix ISS --
GO:0038098 sequestering of BMP from receptor via BMP binding IDA 23063586
GO:0045666 positive regulation of neuron differentiation ISS --
genes like me logo Genes that share ontologies with NBL1: view

Transcripts for NBL1 Gene

Unigene Clusters for NBL1 Gene

Neuroblastoma 1, DAN family BMP antagonist:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NBL1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9: -

Relevant External Links for NBL1 Gene

GeneLoc Exon Structure for
NBL1
ECgene alternative splicing isoforms for
NBL1

Expression for NBL1 Gene

mRNA expression in normal human tissues for NBL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NBL1 Gene

This gene is overexpressed in Ovary (4.9) and Cervix - Ectocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NBL1 Gene

SOURCE GeneReport for Unigene cluster for NBL1 Gene Hs.654502

mRNA Expression by UniProt/SwissProt for NBL1 Gene

P41271-NBL1_HUMAN
Tissue specificity: Most abundant in normal lung and meningioma
genes like me logo Genes that share expressions with NBL1: view

Orthologs for NBL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NBL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 36
  • 95 (a)
OneToMany
NBL1 35
  • 90.32 (n)
  • 91.9 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
OneToMany
NBL1 35
  • 90.63 (n)
  • 92.38 (a)
mouse
(Mus musculus)
Mammalia Nbl1 35
  • 89.51 (n)
  • 93.82 (a)
Nbl1 16
Nbl1 36
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nbl1 35
  • 88.39 (n)
  • 92.7 (a)
chicken
(Gallus gallus)
Aves NBL1 35
  • 79.31 (n)
  • 79.19 (a)
NBL1 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 63 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia nbl1-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nbl1 35
  • 80.15 (n)
  • 80.15 (a)
zebrafish
(Danio rerio)
Actinopterygii nbl1 35
  • 69.39 (n)
  • 68.71 (a)
NBL1 36
  • 52 (a)
OneToMany
Species with no ortholog for NBL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NBL1 Gene

ENSEMBL:
Gene Tree for NBL1 (if available)
TreeFam:
Gene Tree for NBL1 (if available)

Paralogs for NBL1 Gene

Paralogs for NBL1 Gene

Selected SIMAP similar genes for NBL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NBL1: view

Variants for NBL1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NBL1 Gene

Variant ID Type Subtype PubMed ID
nsv508991 CNV Insertion 20534489
esv2395760 CNV Deletion 18987734
dgv187n71 CNV Loss 21882294

Relevant External Links for NBL1 Gene

HapMap Linkage Disequilibrium report
NBL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NBL1 Gene

Disorders for NBL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NBL1 Gene including...

Search for NBL1 Gene in MalaCards »
genes like me logo Genes that share disorders with NBL1: view

No data available for UniProtKB/Swiss-Prot for NBL1 Gene

Publications for NBL1 Gene

  1. Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus. (PMID: 8084583) Enomoto H. … Sakiyama S. (Oncogene 1994) 3 4 23
  2. Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium. (PMID: 11594460) Ahmed A. … Parenteau N. (J. Protein Chem. 2001) 3 4 23
  3. Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. (PMID: 7633401) Caron H. … Westerveld A. (Hum. Mol. Genet. 1995) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. (PMID: 15528323) Chen B. … Yang D. (J. Immunol. 2004) 3

Products for NBL1 Gene

Sources for NBL1 Gene

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