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Aliases for NAXE Gene

Aliases for NAXE Gene

  • NAD(P)HX Epimerase 2 3 4 5
  • YjeF N-Terminal Domain-Containing Protein 1 3 4
  • Apolipoprotein A-I-Binding Protein 3 4
  • NAD(P)H-Hydrate Epimerase 2 3
  • ApoA-I Binding Protein 2 3
  • YjeF_N1 3 4
  • APOA1BP 3 4
  • YJEFN1 3 4
  • AI-BP 3 4
  • AIBP 3 4
  • Apolipoprotein A-I Binding Protein 2
  • EC 5.1.99.6 4
  • PEBEL 3

External Ids for NAXE Gene

Previous HGNC Symbols for NAXE Gene

  • APOA1BP

Summaries for NAXE Gene

Entrez Gene Summary for NAXE Gene

  • The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAXE Gene

NAXE (NAD(P)HX Epimerase) is a Protein Coding gene. Among its related pathways are Nicotinate and nicotinamide metabolism and Metabolism. An important paralog of this gene is YJEFN3.

UniProtKB/Swiss-Prot for NAXE Gene

  • Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAXE Gene

Genomics for NAXE Gene

Regulatory Elements for NAXE Gene

Enhancers for NAXE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156623 0.8 Ensembl ENCODE 23.4 +33.3 33334 2.3 ATF1 GLIS2 ZNF143 ZNF263 SP3 REST MBD2 ZNF610 SMARCA4 GLIS1 NAXE RRNAD1 LOC105371454 C1orf61 MIR9-1 ISG20L2 GPATCH4 LOC101928177 ENSG00000272068
GH01F156569 0.9 FANTOM5 ENCODE 19.5 -20.2 -20219 3.3 ATF1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 GLI4 ZNF2 ETS1 ZNF143 NAXE PEAR1 MEF2D MSTO2P BCAN CCT3 TSACC GPATCH4 TTC24 IQGAP3
GH01F156551 0.7 Ensembl ENCODE 19 -39.0 -39010 3.3 TBP HDAC1 CBX3 RAD21 RFX5 RCOR1 FOS SMARCC1 ZBTB11 CEBPB NAXE MEF2D HAPLN2 BCAN CCT3 C1orf61 MIR9-1 TSACC SMG5 IQGAP3
GH01F156559 0.5 ENCODE 17.7 -31.8 -31849 0.3 ARID1B GATA3 SCRT2 IKZF1 NAXE HAPLN2 C1orf61 MIR9-1 ISG20L2 RRNAD1 IQGAP3 GC01P156524
GH01F156523 1.3 FANTOM5 Ensembl ENCODE 16.9 -66.8 -66762 2.8 HDAC1 PKNOX1 CBX3 RAD21 YY1 ZNF121 EGR2 USF2 CEBPB NR2F2 NAXE IQGAP3 C1orf61 MIR9-1 GPATCH4 ENSG00000260460 MEF2D RRNAD1 GC01P156524
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAXE on UCSC Golden Path with GeneCards custom track

Promoters for NAXE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001040150 138 1401 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF121 ZNF548 PAF1 ZNF263 SP3

Genomic Location for NAXE Gene

Chromosome:
1
Start:
156,591,762 bp from pter
End:
156,594,299 bp from pter
Size:
2,538 bases
Orientation:
Plus strand

Genomic View for NAXE Gene

Genes around NAXE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAXE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAXE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAXE Gene

Proteins for NAXE Gene

  • Protein details for NAXE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCW5-NNRE_HUMAN
    Recommended name:
    NAD(P)H-hydrate epimerase
    Protein Accession:
    Q8NCW5
    Secondary Accessions:
    • B4DGY3
    • Q496C6
    • Q5T3I2

    Protein attributes for NAXE Gene

    Size:
    288 amino acids
    Molecular mass:
    31675 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with APOA1 and APOA2.

    Alternative splice isoforms for NAXE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAXE Gene

Post-translational modifications for NAXE Gene

  • Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAXE Gene

No data available for DME Specific Peptides for NAXE Gene

Domains & Families for NAXE Gene

Protein Domains for NAXE Gene

Suggested Antigen Peptide Sequences for NAXE Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCW5

UniProtKB/Swiss-Prot:

NNRE_HUMAN :
  • Contains 1 YjeF N-terminal domain.
  • Belongs to the NnrE/AIBP family.
Domain:
  • Contains 1 YjeF N-terminal domain.
Family:
  • Belongs to the NnrE/AIBP family.
genes like me logo Genes that share domains with NAXE: view

No data available for Gene Families for NAXE Gene

Function for NAXE Gene

Molecular function for NAXE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide.
UniProtKB/Swiss-Prot CatalyticActivity:
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Enzyme Numbers (IUBMB) for NAXE Gene

Gene Ontology (GO) - Molecular Function for NAXE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 11991719
GO:0016853 isomerase activity IEA --
GO:0042803 protein homodimerization activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NAXE: view
genes like me logo Genes that share phenotypes with NAXE: view

Animal Model Products

miRNA for NAXE Gene

miRTarBase miRNAs that target NAXE

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAXE Gene

Localization for NAXE Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAXE Gene

Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255 HAMAP-Rule:MF_03159}.

Gene Ontology (GO) - Cellular Components for NAXE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 11991719
GO:0005615 extracellular space ISS 22261194
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NAXE: view

No data available for Subcellular locations from COMPARTMENTS for NAXE Gene

Pathways & Interactions for NAXE Gene

genes like me logo Genes that share pathways with NAXE: view

Pathways by source for NAXE Gene

Gene Ontology (GO) - Biological Process for NAXE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006769 nicotinamide metabolic process TAS --
GO:0008150 biological_process ND --
GO:0051289 protein homotetramerization IEA --
genes like me logo Genes that share ontologies with NAXE: view

No data available for SIGNOR curated interactions for NAXE Gene

Transcripts for NAXE Gene

Unigene Clusters for NAXE Gene

Apolipoprotein A-I binding protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAXE Gene

No ASD Table

Relevant External Links for NAXE Gene

GeneLoc Exon Structure for
NAXE
ECgene alternative splicing isoforms for
NAXE

Expression for NAXE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NAXE Gene:

NAXE

SOURCE GeneReport for Unigene cluster for NAXE Gene:

Hs.528320

mRNA Expression by UniProt/SwissProt for NAXE Gene:

Q8NCW5-NNRE_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).
genes like me logo Genes that share expression patterns with NAXE: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NAXE Gene

Orthologs for NAXE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAXE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOA1BP 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia APOA1BP 34 35
  • 90.56 (n)
rat
(Rattus norvegicus)
Mammalia Apoa1bp 34
  • 87.15 (n)
dog
(Canis familiaris)
Mammalia APOA1BP 34 35
  • 85.91 (n)
mouse
(Mus musculus)
Mammalia Apoa1bp 34 16 35
  • 85.21 (n)
oppossum
(Monodelphis domestica)
Mammalia APOA1BP 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOA1BP 35
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOA1BP 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apoa1bp 34
  • 70.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16801 34
zebrafish
(Danio rerio)
Actinopterygii apoa1bp 34 35
  • 65.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2974 34 35
  • 61.65 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003324 34
  • 56.64 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y18D10A.3 34
  • 51.69 (n)
Y18D10A.3 35
  • 32 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL161C 34
  • 51.17 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20768g 34
  • 49.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL200C 34
  • 46.92 (n)
-- 35
  • 40 (a)
OneToMany
NNR1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons PPOX 34
  • 52.21 (n)
rice
(Oryza sativa)
Liliopsida Os10g0377800 34
  • 57.14 (n)
Os.16785 34
bread mold
(Neurospora crassa)
Ascomycetes NCU08070 34
  • 52.85 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug182 34
  • 50.37 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2106 34
Species where no ortholog for NAXE was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAXE Gene

ENSEMBL:
Gene Tree for NAXE (if available)
TreeFam:
Gene Tree for NAXE (if available)

Paralogs for NAXE Gene

Paralogs for NAXE Gene

Pseudogenes.org Pseudogenes for NAXE Gene

genes like me logo Genes that share paralogs with NAXE: view

Variants for NAXE Gene

Sequence variations from dbSNP and Humsavar for NAXE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs879255647 Uncertain significance 156,592,199(+) TACAG(A/C)CATCG reference, missense
rs10127551 -- 156,589,867(+) ttggg(A/G)ggggg upstream-variant-2KB
rs1045786 -- 156,594,009(+) GTGCC(A/C)CCTGC intron-variant, downstream-variant-500B, reference, synonymous-codon
rs10598938 -- 156,594,991(+) TTTAG(-/TC)TCTCT intron-variant, utr-variant-3-prime
rs1063287 -- 156,596,422(-) TGCAG(A/T)GATGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NAXE Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV loss 19592680

Variation tolerance for NAXE Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAXE Gene

Human Gene Mutation Database (HGMD)
NAXE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAXE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAXE Gene

Disorders for NAXE Gene

Relevant External Links for NAXE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAXE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAXE

No disorders were found for NAXE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAXE Gene

Publications for NAXE Gene

  1. Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. (PMID: 11991719) Ritter M. … Schmitz G. (Genomics 2002) 2 3 4 22 64
  2. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PMID: 17533573) Rudolph C. … Schmitz G. (Horm. Metab. Res. 2007) 2 3 22 64
  3. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. (PMID: 21994945) Marbaix A.Y. … Linster C.L. (J. Biol. Chem. 2011) 2 3 64
  4. AIBp regulates mitotic entry and mitotic spindle assembly by controlling activation of both Aurora-A and Plk1. (PMID: 26114227) Chou C.H. … Hong Y.R. (Cell Cycle 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for NAXE Gene

Sources for NAXE Gene

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