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Aliases for NAXE Gene

Aliases for NAXE Gene

  • NAD(P)HX Epimerase 2 3 4
  • Apolipoprotein A-I Binding Protein 2 3 5
  • APOA1BP 3 4 5
  • YjeF N-Terminal Domain-Containing Protein 1 3 4
  • Apolipoprotein A-I-Binding Protein 3 4
  • ApoA-I Binding Protein 2 3
  • YjeF_N1 3 4
  • YJEFN1 3 4
  • AI-BP 3 4
  • AIBP 3 4
  • NAD(P)H-Hydrate Epimerase 2
  • EC 5.1.99.6 4

External Ids for NAXE Gene

Previous HGNC Symbols for NAXE Gene

  • APOA1BP

Summaries for NAXE Gene

Entrez Gene Summary for NAXE Gene

  • The product of this gene interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAXE Gene

NAXE (NAD(P)HX Epimerase) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism. An important paralog of this gene is YJEFN3.

UniProtKB/Swiss-Prot for NAXE Gene

  • Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAXE Gene

Genomics for NAXE Gene

Regulatory Elements for NAXE Gene

Enhancers for NAXE Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAXE on UCSC Golden Path with GeneCards custom track

Promoters for NAXE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAXE on UCSC Golden Path with GeneCards custom track

Genomic Location for NAXE Gene

Chromosome:
1
Start:
156,591,762 bp from pter
End:
156,594,299 bp from pter
Size:
2,538 bases
Orientation:
Plus strand

Genomic View for NAXE Gene

Genes around NAXE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAXE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAXE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAXE Gene

Proteins for NAXE Gene

  • Protein details for NAXE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCW5-NNRE_HUMAN
    Recommended name:
    NAD(P)H-hydrate epimerase
    Protein Accession:
    Q8NCW5
    Secondary Accessions:
    • B4DGY3
    • Q496C6
    • Q5T3I2

    Protein attributes for NAXE Gene

    Size:
    288 amino acids
    Molecular mass:
    31675 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Quaternary structure:
    • Homodimer (By similarity). Interacts with APOA1 and APOA2.

    Alternative splice isoforms for NAXE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAXE Gene

Proteomics data for NAXE Gene at MOPED

Post-translational modifications for NAXE Gene

  • Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAXE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NAXE Gene

Domains & Families for NAXE Gene

Protein Domains for NAXE Gene

Suggested Antigen Peptide Sequences for NAXE Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCW5

UniProtKB/Swiss-Prot:

NNRE_HUMAN :
  • Contains 1 YjeF N-terminal domain.
  • Belongs to the NnrE/AIBP family.
Domain:
  • Contains 1 YjeF N-terminal domain.
Family:
  • Belongs to the NnrE/AIBP family.
genes like me logo Genes that share domains with NAXE: view

No data available for Gene Families for NAXE Gene

Function for NAXE Gene

Molecular function for NAXE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide.
UniProtKB/Swiss-Prot CatalyticActivity:
(6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.

Enzyme Numbers (IUBMB) for NAXE Gene

Gene Ontology (GO) - Molecular Function for NAXE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0052856 NADHX epimerase activity IEA,IBA --
genes like me logo Genes that share ontologies with NAXE: view
genes like me logo Genes that share phenotypes with NAXE: view

Animal Model Products

miRNA for NAXE Gene

miRTarBase miRNAs that target NAXE

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAXE Gene

Localization for NAXE Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAXE Gene

Mitochondrion. Secreted. Note=In sperm, secretion gradually increases during capacitation. {ECO:0000255 HAMAP-Rule:MF_03159}.

Gene Ontology (GO) - Cellular Components for NAXE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 11991719
GO:0005737 cytoplasm IDA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NAXE: view

No data available for Subcellular locations from COMPARTMENTS for NAXE Gene

Pathways & Interactions for NAXE Gene

genes like me logo Genes that share pathways with NAXE: view

Pathways by source for NAXE Gene

Gene Ontology (GO) - Biological Process for NAXE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAXE: view

No data available for SIGNOR curated interactions for NAXE Gene

Drugs & Compounds for NAXE Gene

No Compound Related Data Available

Transcripts for NAXE Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NAXE Gene

No ASD Table

Relevant External Links for NAXE Gene

GeneLoc Exon Structure for
NAXE
ECgene alternative splicing isoforms for
NAXE

Expression for NAXE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for NAXE Gene

Q8NCW5-NNRE_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in kidney, heart and liver. Present in cerebrospinal fluid and urine but not in serum from healthy patients. Present in serum of sepsis patients (at protein level).
genes like me logo Genes that share expression patterns with NAXE: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NAXE Gene

Orthologs for NAXE Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAXE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia APOA1BP 35
  • 90.56 (n)
  • 90.81 (a)
APOA1BP 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOA1BP 35
  • 85.91 (n)
  • 87.5 (a)
APOA1BP 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apoa1bp 35
  • 85.21 (n)
  • 89.85 (a)
Apoa1bp 16
Apoa1bp 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia APOA1BP 35
  • 99.54 (n)
  • 99.31 (a)
APOA1BP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Apoa1bp 35
  • 87.15 (n)
  • 95.12 (a)
oppossum
(Monodelphis domestica)
Mammalia APOA1BP 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia APOA1BP 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia APOA1BP 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apoa1bp 35
  • 70.27 (n)
  • 78.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16801 35
zebrafish
(Danio rerio)
Actinopterygii apoa1bp 35
  • 65.8 (n)
  • 69.78 (a)
apoa1bp 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003324 35
  • 56.64 (n)
  • 57.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2974 35
  • 61.65 (n)
  • 61.95 (a)
CG2974 36
  • 60 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y18D10A.3 35
  • 51.69 (n)
  • 47.58 (a)
Y18D10A.3 36
  • 32 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL161C 35
  • 51.17 (n)
  • 45.61 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F20768g 35
  • 49.85 (n)
  • 52.23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNL200C 35
  • 46.92 (n)
  • 42.49 (a)
-- 36
  • 40 (a)
OneToMany
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PPOX 35
  • 52.21 (n)
  • 54.42 (a)
rice
(Oryza sativa)
Liliopsida Os.16785 35
Os10g0377800 35
  • 57.14 (n)
  • 55.8 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2106 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08070 35
  • 52.85 (n)
  • 49.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mug182 35
  • 50.37 (n)
  • 49.33 (a)
Species with no ortholog for NAXE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAXE Gene

ENSEMBL:
Gene Tree for NAXE (if available)
TreeFam:
Gene Tree for NAXE (if available)

Paralogs for NAXE Gene

Paralogs for NAXE Gene

Pseudogenes.org Pseudogenes for NAXE Gene

genes like me logo Genes that share paralogs with NAXE: view

Variants for NAXE Gene

Sequence variations from dbSNP and Humsavar for NAXE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs942959 -- 156,592,351(+) CCCTT(A/G/T)ACTCT intron-variant
rs942960 -- 156,593,138(+) GAATC(C/T)GGCTC intron-variant
rs942961 -- 156,593,189(+) AGTGG(C/T)GGGCA intron-variant
rs942962 -- 156,593,233(+) TCTCA(A/G)TTTGG intron-variant
rs1925949 -- 156,592,216(+) TCAGT(A/G)GCACA intron-variant

Variation tolerance for NAXE Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NAXE Gene

Disorders for NAXE Gene

Relevant External Links for NAXE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAXE

No disorders were found for NAXE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAXE Gene

Publications for NAXE Gene

  1. Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I. (PMID: 11991719) Ritter M. … Schmitz G. (Genomics 2002) 2 3 4 23 67
  2. ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis. (PMID: 17533573) Rudolph C. … Schmitz G. (Horm. Metab. Res. 2007) 2 3 23
  3. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. (PMID: 21994945) Marbaix A.Y. … Linster C.L. (J. Biol. Chem. 2011) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for NAXE Gene

Sources for NAXE Gene

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