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Aliases for NAXD Gene

Aliases for NAXD Gene

  • NAD(P)HX Dehydratase 2 3 4 5
  • Carbohydrate Kinase Domain-Containing Protein 3 4
  • ATP-Dependent NAD(P)H-Hydrate Dehydratase 2 3
  • Carbohydrate Kinase Domain Containing 2 3
  • ATP-Dependent NAD(P)HX Dehydratase 3 4
  • CARKD 3 4
  • ATP-Dependent (S)-NAD(P)H-Hydrate Dehydratase 3
  • EC 4.2.1.93 4
  • LP3298 3

External Ids for NAXD Gene

Previous HGNC Symbols for NAXD Gene

  • CARKD

Summaries for NAXD Gene

GeneCards Summary for NAXD Gene

NAXD (NAD(P)HX Dehydratase) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism.

UniProtKB/Swiss-Prot for NAXD Gene

  • Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Gene Wiki entry for NAXD Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAXD Gene

Genomics for NAXD Gene

Regulatory Elements for NAXD Gene

Enhancers for NAXD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NAXD on UCSC Golden Path with GeneCards custom track

Promoters for NAXD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAXD on UCSC Golden Path with GeneCards custom track

Genomic Location for NAXD Gene

Chromosome:
13
Start:
110,615,460 bp from pter
End:
110,639,996 bp from pter
Size:
24,537 bases
Orientation:
Plus strand

Genomic View for NAXD Gene

Genes around NAXD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAXD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAXD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAXD Gene

Proteins for NAXD Gene

  • Protein details for NAXD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IW45-NNRD_HUMAN
    Recommended name:
    ATP-dependent (S)-NAD(P)H-hydrate dehydratase
    Protein Accession:
    Q8IW45
    Secondary Accessions:
    • B4DXT4
    • Q5T9X3
    • Q9H7W1
    • Q9NVF5

    Protein attributes for NAXD Gene

    Size:
    347 amino acids
    Molecular mass:
    36576 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAXD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAXD Gene

Post-translational modifications for NAXD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAXD Gene

No data available for DME Specific Peptides for NAXD Gene

Domains & Families for NAXD Gene

Protein Domains for NAXD Gene

Suggested Antigen Peptide Sequences for NAXD Gene

Graphical View of Domain Structure for InterPro Entry

Q8IW45

UniProtKB/Swiss-Prot:

NNRD_HUMAN :
  • Contains 1 YjeF C-terminal domain.
  • Belongs to the NnrD/CARKD family.
Domain:
  • Contains 1 YjeF C-terminal domain.
Family:
  • Belongs to the NnrD/CARKD family.
genes like me logo Genes that share domains with NAXD: view

No data available for Gene Families for NAXD Gene

Function for NAXD Gene

Molecular function for NAXD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide = ADP + phosphate + NADH.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate = ADP + phosphate + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Enzyme Numbers (IUBMB) for NAXD Gene

Gene Ontology (GO) - Molecular Function for NAXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21516116
GO:0005524 ATP binding IEA --
GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity TAS --
GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity IEA --
genes like me logo Genes that share ontologies with NAXD: view
genes like me logo Genes that share phenotypes with NAXD: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAXD Gene

Localization for NAXD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAXD Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for NAXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with NAXD: view

No data available for Subcellular locations from COMPARTMENTS for NAXD Gene

Pathways & Interactions for NAXD Gene

genes like me logo Genes that share pathways with NAXD: view

Gene Ontology (GO) - Biological Process for NAXD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006769 nicotinamide metabolic process TAS --
GO:0008150 biological_process ND --
GO:0046496 nicotinamide nucleotide metabolic process IEA --
genes like me logo Genes that share ontologies with NAXD: view

No data available for SIGNOR curated interactions for NAXD Gene

Drugs & Compounds for NAXD Gene

(3) Drugs for NAXD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
NADH Nutra 0

(2) Additional Compounds for NAXD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with NAXD: view

Transcripts for NAXD Gene

Unigene Clusters for NAXD Gene

Carbohydrate kinase domain containing:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAXD Gene

No ASD Table

Relevant External Links for NAXD Gene

GeneLoc Exon Structure for
NAXD
ECgene alternative splicing isoforms for
NAXD

Expression for NAXD Gene

NURSA nuclear receptor signaling pathways regulating expression of NAXD Gene:

NAXD

SOURCE GeneReport for Unigene cluster for NAXD Gene:

Hs.408324
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NAXD Gene

Orthologs for NAXD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAXD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CARKD 34
  • 80.94 (n)
  • 82.11 (a)
CARKD 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naxd 16
Carkd 35
  • 65 (a)
OneToOne
Carkd 34
  • 82.06 (n)
  • 82.48 (a)
dog
(Canis familiaris)
Mammalia CARKD 35
  • 59 (a)
OneToOne
CARKD 34
  • 80.02 (n)
  • 78.48 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 63 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CARKD 35
  • 98 (a)
OneToOne
CARKD 34
  • 98.85 (n)
  • 98.56 (a)
oppossum
(Monodelphis domestica)
Mammalia CARKD 35
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Carkd 34
  • 81.1 (n)
  • 81.85 (a)
chicken
(Gallus gallus)
Aves CARKD 34
  • 73.14 (n)
  • 76.11 (a)
CARKD 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CARKD 35
  • 46 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12305 34
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9801 34
carkd 34
  • 70.85 (n)
  • 73.67 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:171429 34
  • 65.28 (n)
  • 68.05 (a)
CARKD 35
  • 29 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011983 34
  • 54.8 (n)
  • 50.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10424 34
  • 53.93 (n)
  • 48.93 (a)
CG10424 35
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R107.2 35
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR055W 34
  • 52.43 (n)
  • 49.11 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04510g 34
  • 49.65 (n)
  • 44.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YKL151C 34
  • 48.83 (n)
  • 42.61 (a)
-- 37
-- 35
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19150 34
  • 49.23 (n)
  • 47.68 (a)
soybean
(Glycine max)
eudicotyledons Gma.4754 34
rice
(Oryza sativa)
Liliopsida Os.11423 34
Os11g0276300 34
  • 50.4 (n)
  • 48.79 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.13459 34
bread mold
(Neurospora crassa)
Ascomycetes NCU02513 34
  • 49.83 (n)
  • 45.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC61.03 34
  • 50.06 (n)
  • 48.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToOne
Species where no ortholog for NAXD was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NAXD Gene

ENSEMBL:
Gene Tree for NAXD (if available)
TreeFam:
Gene Tree for NAXD (if available)

Paralogs for NAXD Gene

No data available for Paralogs for NAXD Gene

Variants for NAXD Gene

Sequence variations from dbSNP and Humsavar for NAXD Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs3742191 - 110,627,470(+) TGGAG(A/G)AGTGG nc-transcript-variant, reference, missense
rs3742192 - 110,627,497(+) CTCTT(A/G)TCGTA nc-transcript-variant, reference, missense
rs1044112 - 110,627,506(+) TAGGA(A/C)CTGGC nc-transcript-variant, reference, missense
rs7394 -- 110,639,697(-) AAAGA(C/T)GCTAC nc-transcript-variant, utr-variant-3-prime
rs179356 -- 110,634,260(+) ACTGG(A/G)TAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAXD Gene

Variant ID Type Subtype PubMed ID
nsv1038089 CNV loss 25217958
nsv1042232 CNV gain 25217958
nsv1044234 CNV gain 25217958
nsv1044340 CNV gain 25217958
nsv1046423 CNV gain 25217958
nsv1127364 CNV deletion 24896259
nsv456120 CNV loss 19166990
nsv525124 CNV loss 19592680
nsv563123 CNV loss 21841781
nsv563124 CNV loss 21841781
nsv563125 CNV loss 21841781
nsv832720 CNV loss 17160897

Variation tolerance for NAXD Gene

Residual Variation Intolerance Score: 76.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.65; 65.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAXD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAXD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAXD Gene

Disorders for NAXD Gene

Relevant External Links for NAXD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAXD

No disorders were found for NAXD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAXD Gene

Publications for NAXD Gene

  1. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. (PMID: 21994945) Marbaix A.Y. … Linster C.L. (J. Biol. Chem. 2011) 2 3 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for NAXD Gene

Sources for NAXD Gene

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