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NAV3 Gene

protein-coding   GIFtS: 51
GCID: GC12P078250

Neuron Navigator 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuron Navigator 31 2     KIAA09383 5
Pore Membrane And/Or Filament Interacting Like Protein 11 2     Steerin 31
Unc-53 Homolog 32 3     Steerin-33
POMFIL12 3     Pore Membrane And/Or Filament-Interacting-Like Protein 13
STEERIN32 3     POMFIl15
unc53H32 3     

External Ids:    HGNC: 159981   Entrez Gene: 897952   Ensembl: ENSG000000677987   OMIM: 6116295   UniProtKB: Q8IVL03   

Export aliases for NAV3 gene to outside databases

Previous GC identifers: GC12P078567 GC12P076727 GC12P075278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAV3 Gene:
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded
protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a
variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon
guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has
had its full-length nature determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAV3 Gene:
NAV3 (neuron navigator 3) is a protein-coding gene. Diseases associated with NAV3 include subcutaneous panniculitis-like t-cell lymphoma, and panniculitis. GO annotations related to this gene include nucleoside-triphosphatase activity and nucleotide binding. An important paralog of this gene is NAV1.

UniProtKB/Swiss-Prot: NAV3_HUMAN, Q8IVL0
Function: May regulate IL2 production by T-cells. May be involved in neuron regeneration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAV3 gene promoter:
         STAT1   Elk-1   STAT1alpha   C/EBPalpha   NF-AT   NF-AT4   NF-AT2   NF-AT3   NF-AT1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAV3 promoter sequence
   Search Chromatin IP Primers for NAV3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAV3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q14.3   Ensembl cytogenetic band:  12q21.2   HGNC cytogenetic band: 12q14.3

NAV3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAV3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P078250:  view genomic region     (about GC identifiers)

Start:
78,224,685 bp from pter      End:
78,606,790 bp from pter
Size:
382,106 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAV3_HUMAN, Q8IVL0 (See protein sequence)
Recommended Name: Neuron navigator 3  
Size: 2385 amino acids; 255648 Da
Developmental stage: Expressed in fetal brain
Secondary accessions: Q8NFW7 Q9Y2E7
Alternative splicing: 3 isoforms:  Q8IVL0-1   Q8IVL0-2   Q8IVL0-3   

Explore the universe of human proteins at neXtProt for NAV3: NX_Q8IVL0

Explore proteomics data for NAV3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NAV3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001019554.1  NP_055718.4  

    ENSEMBL proteins: 
     ENSP00000446628   ENSP00000446132   ENSP00000381007   ENSP00000448037   ENSP00000446644  
     ENSP00000448303   ENSP00000448243   ENSP00000228327   ENSP00000266692   ENSP00000444918  

    NAV3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NAV3

    NAV3 Antibody Products:

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    Novus Biologicals NAV3 Antibodies
    Abcam antibodies for NAV3
    Cloud-Clone Corp. Antibodies for NAV3
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    NAV3 Assay Products:

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    GenScript Custom Assay Services for NAV3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAV3
    Cloud-Clone Corp. CLIAs for NAV3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q8IVL0

    ProtoNet protein and cluster: Q8IVL0

    1 Blocks protein domain: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: NAV3_HUMAN, Q8IVL0
    Similarity: Belongs to the Nav/unc-53 family
    Similarity: Contains 1 CH (calponin-homology) domain


    NAV3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAV3_HUMAN, Q8IVL0
    Function: May regulate IL2 production by T-cells. May be involved in neuron regeneration

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding ----
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    NAV3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NAV3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAV3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAV3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAV3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAV3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAV3:
    hsa-mir-29a-3p (MIRT006549)

    Block miRNA regulation of human, mouse, rat NAV3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAV3 (see all 98):
    hsa-miR-548j hsa-miR-411 hsa-miR-128 hsa-miR-30d hsa-miR-3916 hsa-miR-877* hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAV3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAV3
    Predesigned siRNA for gene silencing in human, mouse, rat NAV3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NAV3

    Clone
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    OriGene clones in human, mouse for NAV3 (see all 5)
    OriGene ORF clones in mouse, rat for NAV3
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    GenScript Custom all cDNA clones Services for NAV3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAV3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NAV3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAV3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAV3_HUMAN, Q8IVL0: Nucleus outer membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005635nuclear envelope ----
    GO:0005640nuclear outer membrane IEA--

    NAV3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAV3
    Interactions:

        Search GeneGlobe Interaction Network for NAV3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAV3 (Q8IVL03 ENSP000003810074) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    MDM2Q009873, ENSP000004172814I2D: score=1 STRING: ENSP00000417281
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    UFL1ENSP000003582834STRING: ENSP00000358283
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAV3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAV3 gene (2 alternative transcripts): 
    NM_001024383.1  NM_014903.5  

    Unigene Cluster for NAV3:

    Neuron navigator 3
    Hs.655301  [show with all ESTs]
    Unigene Representative Sequence: NM_014903
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549464 ENST00000536525 ENST00000397909(uc001syo.3 uc001syp.3 uc010sub.2 uc009zsf.3)
    ENST00000549369 ENST00000551277 ENST00000547725 ENST00000550503 ENST00000550673
    ENST00000552895 ENST00000550788 ENST00000548948 ENST00000552300 ENST00000551162
    ENST00000547884 ENST00000228327 ENST00000266692 ENST00000541270
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAV3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAV3 (see all 98):
    hsa-miR-548j hsa-miR-411 hsa-miR-128 hsa-miR-30d hsa-miR-3916 hsa-miR-877* hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAV3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAV3
    Predesigned siRNA for gene silencing in human, mouse, rat NAV3
    Clone
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    OriGene clones in human, mouse for NAV3 (see all 5)
    OriGene ORF clones in mouse, rat for NAV3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NAV3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAV3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NAV3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAV3
      QuantiTect SYBR Green Assays in human, mouse, rat NAV3
      QuantiFast Probe-based Assays in human, mouse, rat NAV3

    Additional mRNA sequence: 

    AB023155.2 AF397731.1 AJ488201.1 AK022070.1 AK294988.1 AK298525.1 AL080104.1 BC017667.2 

    8 DOTS entries:

    DT.91854748  DT.113105  DT.100644871  DT.121121108  DT.121121103  DT.121121105  DT.121121129  DT.427570 

    Selected AceView cDNA sequences (see all 93):

    AI929520 BM713910 AA910041 AF397731 BM714931 AI814858 AJ488201 AB023155 
    AI539348 F10608 AA082052 AU120878 BM684673 Z44883 Z38462 NM_014903 
    AA374301 F13011 BU735926 Z42103 AI929563 AA716602 AI090184 AA081703 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAV3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NAV3 Expression
    About this image


    NAV3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (Naive)
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Human umbilical vein endothelial cells (HUVEC)
     
     Brain (Nervous System)
             Endothelial Cells Blood Brain Barrier
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
    NAV3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAV3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655301

    UniProtKB/Swiss-Prot: NAV3_HUMAN, Q8IVL0
    Tissue specificity: Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated
    T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NAV3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nav31 , 5 neuron navigator 31, 5 87.67(n)1
    94.03(a)1
      10 (57.18 cM)5
    2603151  NM_001081035.11  NP_001074504.11 
     1096826605 
    chicken
    (Gallus gallus)
    Aves NAV31 neuron navigator 3 81.35(n)
    88.21(a)
      417869  NM_001159347.2  NP_001152819.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAV36
    neuron navigator 3
    85(a)
    1 ↔ 1
    5(41520449-41742651)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nav31 neuron navigator 3 75.63(n)
    80.76(a)
      100486471  XM_002935642.2  XP_002935688.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nav31 neuron navigator 3 66.23(n)
    67.8(a)
      567779  NM_001045143.2  NP_001038608.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sick6
    sickie
    25(a)
    1 → many
    2L(19796365-19958424)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-536
    Protein UNC-53, isoform d (unc-53) mRNA, complete ...
    24(a)
    1 → many
    II(11058101-11089456) WBGene00006788


    ENSEMBL Gene Tree for NAV3 (if available)
    TreeFam Gene Tree for NAV3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAV3 gene
    NAV12  NAV22  
    4 SIMAP similar genes for NAV3 using alignment to 11 protein entries:     NAV3_HUMAN (see all proteins):
    NAV2    ACTN1    NAV1    DKFZp434O2321

    NAV3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAV3 (see all 8030)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105400711,2
    C--78137431(+) CCAGT-/AAA   
       
    /AAAA
    aaaaa
    2 -- int1 cds11NA 2
    rs1438390531,2
    --78223104(+) TTCCTG/TGAGTG 1 -- us2k10--------
    rs1875538761,2
    --78223149(+) TTGCTA/GGCAAT 1 -- us2k10--------
    rs1384134521,2
    --78223176(+) ATATGC/TTTTGA 1 -- us2k10--------
    rs1932835381,2
    --78223200(+) AATCAA/GTTTTT 1 -- us2k10--------
    rs15690281,2
    C,F,O,A--78223287(+) CTAAAC/ACTCAT 1 -- us2k110Minor allele frequency- A:0.26EA NA WA 580
    rs122312961,2
    C,F,H--78223346(+) AAGTTA/GTAATG 1 -- us2k111Minor allele frequency- N:0.01NS EA NA CSA 760
    rs1429889891,2
    C--78223422(+) ACCACC/TAGTGT 1 -- us2k10--------
    rs1176968321,2
    F--78223452(+) CCCGCT/GGTGTA 1 -- us2k11Minor allele frequency- G:0.02EA 120
    rs1855097171,2
    --78223465(+) GCCCAC/TTTGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAV3 (78224685 - 78474685 bp, first 250kb of NAV3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NAV3 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746096CNV Deletion23290073
    esv2746098CNV Deletion23290073
    esv2199986CNV Deletion18987734
    esv2931CNV Deletion18987735
    esv2746095CNV Deletion23290073
    esv2669115CNV Deletion23128226
    esv2611482CNV Insertion19546169
    esv272884CNV Insertion20981092
    nsv781CNV Insertion18451855
    nsv507656CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAV3
    DNA2.0 Custom Variant and Variant Library Synthesis for NAV3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611629    OMIM disorders: --

    UniProtKB/Swiss-Prot: NAV3_HUMAN, Q8IVL0
  • Note=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome.
    Translocation t(12;18)(q21;q21.2)

  • 15 diseases for NAV3:    
    About MalaCards
    subcutaneous panniculitis-like t-cell lymphoma    panniculitis    familial colorectal cancer    neuronitis
    cutaneous t cell lymphoma    adult t-cell leukemia    fanconi's anemia    t-cell leukemia
    colorectal cancer    influenza    neuroblastoma    leukemia
    multiple myeloma    myeloma    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for NAV3:
    Cutaneous T cell lymphoma     Influenza

    NAV3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NAV3
    Human Genome Epidemiology (HuGE) Navigator: NAV3 (6 documents)

    Export disorders for NAV3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAV3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NAV3)
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    1. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PubMed id 12079279)1, 2, 3 Maes T.... Buesa C. (Genomics 2002)
    2. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PubMed id 12062803)1, 2, 3 Coy J.F.... Poustka A. (Gene 2002)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PubMed id 15158073)1, 2 Peeters P.J.... Moechars D.W.E. (Brain Res. Dev. Brain Res. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    7. Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. (PubMed id 16166283)2, 9 Karenko L.... Ranki A. (Cancer Res. 2005)
    8. Neuron navigator 3 alterations in nervous system tumors associate with tumor malignancy grade and prognosis. (PubMed id 23097141)1 Carlsson E....Ranki A. (amp 2013)
    9. Potential role of a navigator gene NAV3 in colorectal cancer. (PubMed id 22173670)1 Carlsson E....Krohn K. (Br. J. Cancer 2012)
    10. NAV3 copy number changes and target genes in basal and squamous cell cancers. (PubMed id 21995814)1 Maliniemi P....Ranki A. (Exp. Dermatol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 89795 HGNC: 15998 AceView: NAV3 Ensembl:ENSG00000067798 euGenes: HUgn89795
    ECgene: NAV3 H-InvDB: NAV3

    (According to HUGE)
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    HUGE: KIAA0938

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAV3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAV3 gene:
    Search GeneIP for patents involving NAV3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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