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Aliases for NAV3 Gene

Aliases for NAV3 Gene

  • Neuron Navigator 3 2 3 5
  • Pore Membrane And/Or Filament Interacting Like Protein 1 2 3
  • Unc-53 Homolog 3 3 4
  • STEERIN3 3 4
  • POMFIL1 3 4
  • Unc53H3 3 4
  • Pore Membrane And/Or Filament-Interacting-Like Protein 1 4
  • Steerin 3 2
  • Steerin-3 4
  • KIAA0938 4

External Ids for NAV3 Gene

Previous GeneCards Identifiers for NAV3 Gene

  • GC12P078250
  • GC12P078567
  • GC12P076727
  • GC12P075278
  • GC12P077326

Summaries for NAV3 Gene

Entrez Gene Summary for NAV3 Gene

  • This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAV3 Gene

NAV3 (Neuron Navigator 3) is a Protein Coding gene. Diseases associated with NAV3 include subcutaneous panniculitis-like t-cell lymphoma. An important paralog of this gene is NAV2.

UniProtKB/Swiss-Prot for NAV3 Gene

  • May regulate IL2 production by T-cells. May be involved in neuron regeneration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAV3 Gene

Genomics for NAV3 Gene

Regulatory Elements for NAV3 Gene

Enhancers for NAV3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAV3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAV3 Gene

Chromosome:
12
Start:
77,571,862 bp from pter
End:
78,213,012 bp from pter
Size:
641,151 bases
Orientation:
Plus strand

Genomic View for NAV3 Gene

Genes around NAV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAV3 Gene

Proteins for NAV3 Gene

  • Protein details for NAV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVL0-NAV3_HUMAN
    Recommended name:
    Neuron navigator 3
    Protein Accession:
    Q8IVL0
    Secondary Accessions:
    • Q8NFW7
    • Q9Y2E7

    Protein attributes for NAV3 Gene

    Size:
    2385 amino acids
    Molecular mass:
    255648 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAV3 Gene

Proteomics data for NAV3 Gene at MOPED

Post-translational modifications for NAV3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAV3 Gene

Domains & Families for NAV3 Gene

Protein Domains for NAV3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVL0

UniProtKB/Swiss-Prot:

NAV3_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the Nav/unc-53 family.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the Nav/unc-53 family.
genes like me logo Genes that share domains with NAV3: view

No data available for Gene Families for NAV3 Gene

Function for NAV3 Gene

Molecular function for NAV3 Gene

UniProtKB/Swiss-Prot Function:
May regulate IL2 production by T-cells. May be involved in neuron regeneration.
genes like me logo Genes that share phenotypes with NAV3: view

Animal Model Products

miRNA for NAV3 Gene

miRTarBase miRNAs that target NAV3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAV3 Gene

Localization for NAV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAV3 Gene

Nucleus outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAV3 Gene COMPARTMENTS Subcellular localization image for NAV3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NAV3 Gene

Pathways & Interactions for NAV3 Gene

SuperPathways for NAV3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAV3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAV3 Gene

Drugs & Compounds for NAV3 Gene

No Compound Related Data Available

Transcripts for NAV3 Gene

Unigene Clusters for NAV3 Gene

Neuron navigator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAV3 Gene

No ASD Table

Relevant External Links for NAV3 Gene

GeneLoc Exon Structure for
NAV3
ECgene alternative splicing isoforms for
NAV3

Expression for NAV3 Gene

mRNA expression in normal human tissues for NAV3 Gene

Protein differential expression in normal tissues from HIPED for NAV3 Gene

This gene is overexpressed in Breast (30.3), Cervix (20.3), and Brain (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAV3 Gene



SOURCE GeneReport for Unigene cluster for NAV3 Gene Hs.655301

mRNA Expression by UniProt/SwissProt for NAV3 Gene

Q8IVL0-NAV3_HUMAN
Tissue specificity: Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
genes like me logo Genes that share expression patterns with NAV3: view

Protein tissue co-expression partners for NAV3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NAV3 Gene

Orthologs for NAV3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAV3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAV3 35
  • 90.96 (n)
  • 95.05 (a)
NAV3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAV3 35
  • 91.35 (n)
  • 95.32 (a)
NAV3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nav3 35
  • 87.67 (n)
  • 94.03 (a)
Nav3 16
Nav3 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAV3 35
  • 99.61 (n)
  • 99.7 (a)
NAV3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nav3 35
  • 87.38 (n)
  • 93.27 (a)
oppossum
(Monodelphis domestica)
Mammalia NAV3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
chicken
(Gallus gallus)
Aves NAV3 35
  • 81.35 (n)
  • 88.21 (a)
NAV3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAV3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nav3 35
  • 75.63 (n)
  • 80.76 (a)
zebrafish
(Danio rerio)
Actinopterygii nav3 35
  • 66.23 (n)
  • 67.8 (a)
nav3 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sick 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-53 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for NAV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAV3 Gene

ENSEMBL:
Gene Tree for NAV3 (if available)
TreeFam:
Gene Tree for NAV3 (if available)

Paralogs for NAV3 Gene

Paralogs for NAV3 Gene

genes like me logo Genes that share paralogs with NAV3: view

Variants for NAV3 Gene

Sequence variations from dbSNP and Humsavar for NAV3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10735309 - 77,831,594(+) AACTT(A/G/T)CTGAA intron-variant, reference, missense
rs34195711 - 77,968,660(+) TCCAT(C/G/T)GGAAG reference, missense, utr-variant-5-prime
VAR_032251 -
rs1920425 -- 77,913,036(-) AACTG(C/T)GTCTC intron-variant
rs1920426 -- 77,912,723(-) AACCC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAV3 Gene

Variant ID Type Subtype PubMed ID
nsv518576 CNV Loss 19592680
nsv899320 CNV Loss 21882294
esv2746095 CNV Deletion 23290073
nsv469481 CNV Loss 19166990
esv2607464 CNV Loss 19546169
esv2746096 CNV Deletion 23290073
esv2199986 CNV Deletion 18987734
esv2931 CNV Deletion 18987735
esv2746098 CNV Deletion 23290073
esv2669115 CNV Deletion 23128226
esv2611482 CNV Insertion 19546169
esv272884 CNV Insertion 20981092
esv269582 CNV Insertion 20981092
esv6891 CNV Gain 19470904
nsv781 CNV Insertion 18451855
nsv826443 CNV Gain 20364138
dgv206n27 CNV Loss 19166990
nsv469485 CNV Loss 19166990
dgv297n67 CNV Loss 20364138
nsv507656 CNV Insertion 20534489

Variation tolerance for NAV3 Gene

Residual Variation Intolerance Score: 0.307% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAV3 Gene

HapMap Linkage Disequilibrium report
NAV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAV3 Gene

Disorders for NAV3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAV3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
subcutaneous panniculitis-like t-cell lymphoma
  • sptcl
- elite association - COSMIC cancer census association via MalaCards
Search NAV3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NAV3_HUMAN
  • Note=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome (PubMed:16166283). Translocation t(12;18)(q21;q21.2) (PubMed:16166283). {ECO:0000269 PubMed:16166283}.

Relevant External Links for NAV3

Genetic Association Database (GAD)
NAV3
Human Genome Epidemiology (HuGE) Navigator
NAV3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAV3
genes like me logo Genes that share disorders with NAV3: view

No data available for Genatlas for NAV3 Gene

Publications for NAV3 Gene

  1. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PMID: 12079279) Maes T. … Buesa C. (Genomics 2002) 2 3 4 67
  2. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PMID: 12062803) Coy J.F. … Poustka A. (Gene 2002) 2 3
  3. Navigator-3, a modulator of cell migration, may act as a suppressor of breast cancer progression. (PMID: 25678558) Cohen-Dvashi H. … Yarden Y. (EMBO Mol Med 2015) 3
  4. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. (PMID: 24057671) Chimusa E.R. … Hoal E.G. (Hum. Mol. Genet. 2014) 3
  5. Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension. (PMID: 25065758) van Haren J. … Galjart N. (Curr. Biol. 2014) 3

Products for NAV3 Gene

Sources for NAV3 Gene

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