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Aliases for NAV3 Gene

Aliases for NAV3 Gene

  • Neuron Navigator 3 2 3
  • POMFIL1 3 4 6
  • Pore Membrane And/Or Filament Interacting Like Protein 1 2 3
  • Unc-53 Homolog 3 3 4
  • STEERIN3 3 4
  • KIAA0938 4 6
  • Unc53H3 3 4
  • Pore Membrane And/Or Filament-Interacting-Like Protein 1 4
  • Steerin 3 2
  • Steerin-3 4

External Ids for NAV3 Gene

Previous GeneCards Identifiers for NAV3 Gene

  • GC12P078250
  • GC12P078567
  • GC12P076727
  • GC12P075278

Summaries for NAV3 Gene

Entrez Gene Summary for NAV3 Gene

  • This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAV3 Gene

NAV3 (Neuron Navigator 3) is a Protein Coding gene. Diseases associated with NAV3 include subcutaneous panniculitis-like t-cell lymphoma. GO annotations related to this gene include nucleotide binding and nucleoside-triphosphatase activity. An important paralog of this gene is NAV2.

UniProtKB/Swiss-Prot for NAV3 Gene

  • May regulate IL2 production by T-cells. May be involved in neuron regeneration.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAV3 Gene

Genomics for NAV3 Gene

Regulatory Elements for NAV3 Gene

Genomic Location for NAV3 Gene

Start:
77,325,000 bp from pter
End:
78,213,012 bp from pter
Size:
888,013 bases
Orientation:
Plus strand

Genomic View for NAV3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAV3 Gene

Proteins for NAV3 Gene

  • Protein details for NAV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVL0-NAV3_HUMAN
    Recommended name:
    Neuron navigator 3
    Protein Accession:
    Q8IVL0
    Secondary Accessions:
    • Q8NFW7
    • Q9Y2E7

    Protein attributes for NAV3 Gene

    Size:
    2385 amino acids
    Molecular mass:
    255648 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAV3 Gene

Proteomics data for NAV3 Gene at MOPED

Post-translational modifications for NAV3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAV3 Gene

Domains for NAV3 Gene

Protein Domains for NAV3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVL0

UniProtKB/Swiss-Prot:

NAV3_HUMAN :
  • Q8IVL0
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the Nav/unc-53 family.
genes like me logo Genes that share domains with NAV3: view

No data available for Gene Families for NAV3 Gene

Function for NAV3 Gene

Molecular function for NAV3 Gene

UniProtKB/Swiss-Prot Function: May regulate IL2 production by T-cells. May be involved in neuron regeneration.

Gene Ontology (GO) - Molecular Function for NAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with NAV3: view

Phenotypes for NAV3 Gene

GenomeRNAi human phenotypes for NAV3:
genes like me logo Genes that share phenotypes with NAV3: view

miRNA for NAV3 Gene

miRTarBase miRNAs that target NAV3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAV3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAV3 Gene

Localization for NAV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAV3 Gene

Nucleus outer membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAV3 Gene COMPARTMENTS Subcellular localization image for NAV3 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005635 nuclear envelope --
GO:0005640 nuclear outer membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with NAV3: view

Pathways for NAV3 Gene

SuperPathways for NAV3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAV3 Gene

None

No data available for Pathways by source for NAV3 Gene

Transcripts for NAV3 Gene

Unigene Clusters for NAV3 Gene

Neuron navigator 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAV3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NAV3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAV3 Gene

No ASD Table

Relevant External Links for NAV3 Gene

GeneLoc Exon Structure for
NAV3
ECgene alternative splicing isoforms for
NAV3

Expression for NAV3 Gene

mRNA expression in normal human tissues for NAV3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAV3 Gene

SOURCE GeneReport for Unigene cluster for NAV3 Gene Hs.655301

mRNA Expression by UniProt/SwissProt for NAV3 Gene

Q8IVL0-NAV3_HUMAN
Tissue specificity: Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.
genes like me logo Genes that share expressions with NAV3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NAV3 Gene

Orthologs for NAV3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAV3 35
  • 99.61 (n)
  • 99.7 (a)
NAV3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAV3 35
  • 90.96 (n)
  • 95.05 (a)
NAV3 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAV3 35
  • 91.35 (n)
  • 95.32 (a)
NAV3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nav3 35
  • 87.67 (n)
  • 94.03 (a)
Nav3 16
Nav3 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAV3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nav3 35
  • 87.38 (n)
  • 93.27 (a)
chicken
(Gallus gallus)
Aves NAV3 35
  • 81.35 (n)
  • 88.21 (a)
NAV3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAV3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nav3 35
  • 75.63 (n)
  • 80.76 (a)
zebrafish
(Danio rerio)
Actinopterygii nav3 35
  • 66.23 (n)
  • 67.8 (a)
nav3 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sick 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-53 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for NAV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAV3 Gene

ENSEMBL:
Gene Tree for NAV3 (if available)
TreeFam:
Gene Tree for NAV3 (if available)

Paralogs for NAV3 Gene

Paralogs for NAV3 Gene

genes like me logo Genes that share paralogs with NAV3: view

Variants for NAV3 Gene

Sequence variations from dbSNP and Humsavar for NAV3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs167274 -- 78,138,532(+) CCACT(A/C)AGTTC intron-variant
rs167275 -- 78,138,912(+) ACTAG(A/G)TTGAA intron-variant
rs167276 -- 78,077,969(+) gtctc(A/T)ccctt intron-variant
rs167277 -- 78,089,299(+) ACATG(A/C)TAAAC intron-variant
rs169947 -- 78,078,453(+) tgcag(G/T)ggcgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAV3 Gene

Variant ID Type Subtype PubMed ID
nsv518576 CNV Loss 19592680
nsv899320 CNV Loss 21882294
esv2746095 CNV Deletion 23290073
nsv469481 CNV Loss 19166990
esv2607464 CNV Loss 19546169
esv2746096 CNV Deletion 23290073
esv2199986 CNV Deletion 18987734
esv2931 CNV Deletion 18987735
esv2746098 CNV Deletion 23290073
esv2669115 CNV Deletion 23128226
esv2611482 CNV Insertion 19546169
esv272884 CNV Insertion 20981092
esv269582 CNV Insertion 20981092
esv6891 CNV Gain 19470904
nsv781 CNV Insertion 18451855
nsv826443 CNV Gain 20364138
dgv206n27 CNV Loss 19166990
nsv469485 CNV Loss 19166990
dgv297n67 CNV Loss 20364138
nsv507656 CNV Insertion 20534489

Relevant External Links for NAV3 Gene

HapMap Linkage Disequilibrium report
NAV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAV3 Gene

Disorders for NAV3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NAV3 Gene including...

Search for NAV3 Gene in MalaCards »

UniProtKB/Swiss-Prot

NAV3_HUMAN
  • Note=A chromosomal aberration disrupting NAV3 has been found in patients with Sezary syndrome. Translocation t(12;18)(q21;q21.2).

(2) University of Copenhagen DISEASES for NAV3 Gene

Relevant External Links for NAV3

Genetic Association Database (GAD)
NAV3
Human Genome Epidemiology (HuGE) Navigator
NAV3
genes like me logo Genes that share disorders with NAV3: view

Publications for NAV3 Gene

  1. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PMID: 12062803) Coy J.F. … Poustka A. (Gene 2002) 2 3 4
  2. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PMID: 12079279) Maes T. … Buesa C. (Genomics 2002) 2 3 4
  3. Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. (PMID: 16166283) Karenko L. … Ranki A. (Cancer Res. 2005) 4 23
  4. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10231032) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  5. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PMID: 15158073) Peeters P.J. … Moechars D.W.E. (Brain Res. Dev. Brain Res. 2004) 3 4

Products for NAV3 Gene

Sources for NAV3 Gene

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