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NAV2 Gene

protein-coding   GIFtS: 57
GCID: GC11P019372

Neuron Navigator 2

  See NAV2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section


Aliases
Neuron Navigator 21 2     helicase1
RAINB12 3 5     Pore Membrane And/Or Filament Interacting Like Protein 21
Retinoic Acid Inducible Gene In Neuroblastoma 11 2     UNC53H22
Pore Membrane And/Or Filament-Interacting-Like Protein 22 3     Helicase, APC Down-Regulated 12
Unc-53 Homolog 22 3     steerin-22
HELAD12 3     EC 3.6.4.123
POMFIL22 3     Steerin-23
STEERIN22 3     Helicase APC Down-Regulated 13
KIAA14193 5     Retinoic Acid Inducible In Neuroblastoma 13
APC Down-Regulated 11     unc53H23

External Ids:    HGNC: 159971   Entrez Gene: 897972   Ensembl: ENSG000001668337   OMIM: 6070265   UniProtKB: Q8IVL13   

Export aliases for NAV2 gene to outside databases

Previous GC identifiers: GC11P020896 GC11P020678 GC11P019411 GC11P019699 GC11P019691 GC11P019056


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section


Entrez Gene summary for NAV2 Gene:
This gene encodes a member of the neuron navigator gene family, which may play a role in cellular growth and
migration. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Oct 2011)

GeneCards Summary for NAV2 Gene:
NAV2 (neuron navigator 2) is a protein-coding gene. Diseases associated with NAV2 include neuroblastoma 1, and neuroblastoma. GO annotations related to this gene include heparin binding and helicase activity. An important paralog of this gene is NAV1.

UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1
Function: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development,
specifically in the development of different sensory organs

Gene Wiki entry for NAV2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAV2 gene promoter:
         Egr-3   STAT1   Pbx1a   STAT1beta   Nkx2-5   STAT1alpha   Pax-3   POU2F1   E2F   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NAV2 promoter sequence
   Search Chromatin IP Primers for NAV2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAV2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

NAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAV2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P019372:  view genomic region     (about GC identifiers)

Start:
19,372,271 bp from pter      End:
20,143,147 bp from pter
Size:
770,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or GeneTex.)
About This Section


UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1 (See protein sequence)
Recommended Name: Neuron navigator 2  
Size: 2488 amino acids; 268167 Da
Developmental stage: Highly expressed in the nervous system of developing embryos. Also expressed in fetal heart,
liver and kidney
Caution: PubMed:15158073 experiments have been carried out in mouse
Sequence caution: Sequence=BAA92657.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB85038.1; Type=Frameshift; Positions=2074;
1 PDB 3D structure from and Proteopedia for NAV2:
2YRN (3D)    
Secondary accessions: A6NEC1 Q8IVK3 Q8IVK4 Q8IVK5 Q8IVK6 Q8IVK7 Q8IVK8 Q8NHC9 Q8NHD0 Q8TDE9
Q8TDF0 Q8TEB3 Q96B30 Q9NUZ6 Q9NVM7 Q9P2C8
Alternative splicing: 13 isoforms:  Q8IVL1-1   Q8IVL1-2   Q8IVL1-3   Q8IVL1-4   Q8IVL1-5   Q8IVL1-6   Q8IVL1-7   Q8IVL1-8   
Q8IVL1-9   Q8IVL1-10   Q8IVL1-11   Q8IVL1-12   Q8IVL1-13   

Explore the universe of human proteins at neXtProt for NAV2: NX_Q8IVL1

Explore proteomics data for NAV2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NAV2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001104488.1  NP_001104489.1  NP_001231892.1  NP_660093.2  NP_892009.3  

    ENSEMBL proteins: 
     ENSP00000353871   ENSP00000379394   ENSP00000309577   ENSP00000379396   ENSP00000437316  
     ENSP00000437136   ENSP00000431276   ENSP00000435395   ENSP00000443489   ENSP00000312169  

    NAV2 Human Recombinant Protein Products:

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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NAV2
    GenScript Custom Purified and Recombinant Proteins Services for NAV2
    Novus Biologicals NAV2 Proteins
    Novus Biologicals NAV2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NAV2

     
    Search eBioscience for Proteins for NAV2 

     
    Search GeneTex for Proteins for NAV2 

     
    antibodies-online proteins for NAV2 (4 products) 

     
    Search antibodies-online for peptides for NAV2

    NAV2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NAV2 Antibodies
    Abcam antibodies for NAV2
    Cloud-Clone Corp. Antibodies for NAV2
    Search ThermoFisher Antibodies for NAV2

     
    GeneTex Antibodies for NAV2:  
                        NAV2 Antibodies
    antibodies-online antibodies for NAV2 (19 products) 

    NAV2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAV2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAV2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAV2
    Cloud-Clone Corp. CLIAs for NAV2
    Search eBioscience for ELISAs for NAV2 
    antibodies-online kits for NAV2 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
    About This Section

    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q8IVL1

    ProtoNet protein and cluster: Q8IVL1

    1 Blocks protein domain: IPB001715 Calponin-like actin-binding

    UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1
    Similarity: Belongs to the Nav/unc-53 family
    Similarity: Contains 1 CH (calponin-homology) domain


    Find genes that share domains with NAV2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway, and/or Taconic Biosciences, CRISPR knockouts from OriGene, transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Clones from OriGene, GenScript, Sino Biological, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAV2_HUMAN, Q8IVL1
    Function: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development,
    specifically in the development of different sensory organs
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Induction: By all-trans retinoic acid (ATRA). Up-regulated in colorectal carcinomas

         Enzyme Number (IUBMB): EC 3.6.4.121

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004386helicase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008201heparin binding IEA--
         
    Find genes that share ontologies with NAV2           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nav2):
     behavior/neurological  growth/size/body  integument  nervous system  taste/olfaction 
     vision/eye 

    Find genes that share phenotypes with NAV2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NAV2

        Search Taconic Biosciences for animal models for NAV2 

    CRISPR Knockouts: 
       OriGene CRISPR knockouts for NAV2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAV2:
    hsa-mir-16-5p (MIRT051065), hsa-mir-98-5p (MIRT027632)

    Block miRNA regulation of human, mouse, rat NAV2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAV2 (see all 84):
    hsa-miR-1321 hsa-miR-106a hsa-miR-3678-5p hsa-miR-128 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNAV2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAV2
    Predesigned siRNA for gene silencing in human, mouse, rat NAV2

    Clone
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    OriGene clones in human, mouse for NAV2 (see all 20)
    OriGene ORF clones in mouse, rat for NAV2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NAV2
    Browse Sino Biological Human cDNA Clones
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAV2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAV2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section


    Subcellular locations from UniProtKB/Swiss-Prot
    NAV2_HUMAN, Q8IVL1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular2
    cytoskeleton1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005614interstitial matrix IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with NAV2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
    About This Section






        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAV2
    Interactions:

        Search GeneGlobe Interaction Network for NAV2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAV2 (Q8IVL12, 3 ENSP000003793944) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIAS2O759282, 3, ENSP000003816484MINT-66145 I2D: score=5 STRING: ENSP00000381648
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    RRASP103013, ENSP000002467924I2D: score=1 STRING: ENSP00000246792
    ING5Q8WYH83, ENSP000003221424I2D: score=4 STRING: ENSP00000322142
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003025regulation of systemic arterial blood pressure by baroreceptor feedback IEA--
    GO:0007399nervous system development ----
    GO:0007605sensory perception of sound IEA--
    GO:0007608sensory perception of smell IEA--
    GO:0007626locomotory behavior IEA--

    Find genes that share ontologies with NAV2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
    About This Section

    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAV2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section


    REFSEQ mRNAs for NAV2 gene (12 alternative transcripts): 
    NM_001111018.1  NM_001111019.2  NM_001244963.1  NM_145117.4  NM_182964.5  XM_005253214.2  XM_006718364.1  XM_006718365.1  
    XM_006718366.1  XM_006718367.1  XM_006718368.1  XM_006718369.1  

    Unigene Clusters for NAV2:

    Neuron navigator 2
    Hs.502116  [show with all ESTs], Hs.639427 , Hs.639428
    Unigene Representative Sequences: NM_001244963, AJ488204, AJ488202
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360655(uc001mpp.3) ENST00000396085(uc010rdm.2 uc001mpr.4 uc021qew.1)
    ENST00000349880 ENST00000396087 ENST00000534229 ENST00000528008 ENST00000533917(uc009yhy.1)
    ENST00000525322(uc001mpt.2) ENST00000530408 ENST00000534299 ENST00000526675
    ENST00000533746 ENST00000525025 ENST00000528923 ENST00000527559 ENST00000540292
    ENST00000311043(uc009yhx.3 uc009yhz.3 uc001mpu.3 uc001mpv.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAV2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAV2 (see all 84):
    hsa-miR-1321 hsa-miR-106a hsa-miR-3678-5p hsa-miR-128 hsa-miR-519a hsa-miR-208b hsa-miR-93 hsa-miR-149
    SwitchGear 3'UTR luciferase reporter plasmidNAV2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAV2
    Predesigned siRNA for gene silencing in human, mouse, rat NAV2
    Clone
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    OriGene clones in human, mouse for NAV2 (see all 20)
    OriGene ORF clones in mouse, rat for NAV2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NAV2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NAV2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NAV2
      QuantiTect SYBR Green Assays in human, mouse, rat NAV2
      QuantiFast Probe-based Assays in human, mouse, rat NAV2

    Additional mRNA sequence: AJ488202.1 

    20 DOTS entries:

    DT.406815  DT.100785395  DT.445168  DT.100699961  DT.100785398  DT.100023051  DT.100640016  DT.100721645 
    DT.100693167  DT.95273461  DT.97823709  DT.120702063  DT.120702137  DT.40239601  DT.421264  DT.117695 
    DT.120702225  DT.408040  DT.91711310  DT.91894626 

    Selected AceView cDNA sequences (see all 47):

    AI739417 AA984260 M79074 AJ488208 AJ488205 BX502578 BX502564 BM714992 
    AA150056 BM800972 BG763937 BX485661 AA152178 AL699569 BQ431205 BG924941 
    BU739339 CD654605 BM676695 AA037745 R97894 T24445 CD691701 BF511334 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAV2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a ·
    SP1:                                                                                                                                                        -   
    SP2:        -     -                                                                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:              -                                                                                                                                             

    ExUns: 25b ^ 26 ^ 27a · 27b ^ 28a · 28b
    SP1:              -                     
    SP2:                                    
    SP3:                                    
    SP4:              -                     
    SP5:                                    


    ECgene alternative splicing isoforms for NAV2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAV2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCAATAAA
    NAV2 Expression
    About this image


    NAV2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Ectoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Intraembryonic Ectoderm Cells Ectoderm
             Ectoderm
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Peripheral Nervous System (Nervous System)
             Immature Schwann Cells Peripheral Nerve Domain
     
     Bone (Muscoskeletal System)
             Bone Marrow
    NAV2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAV2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.502116 Hs.639427 Hs.639428

    UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1
    Tissue specificity: Highly expressed in the brain, kidney and liver. Also expressed in the thyroid, mammary gland,
    spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers

        Custom PCR Arrays for NAV2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NAV2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NAV2
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    QuantiFast Probe-based Assays in human, mouse, rat NAV2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section


    This gene was present in the common ancestor of animals.

    Orthologs for NAV2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nav21 , 5 neuron navigator 21, 5 87.95(n)1
    93.31(a)1
      7 (31.23 cM)5
    782861  NM_175272.31  NP_780481.21 
     489087165 
    chicken
    (Gallus gallus)
    Aves NAV21 neuron navigator 2 79.49(n)
    87.31(a)
      422977  XM_004941317.1  XP_004941374.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAV26
    neuron navigator 2
    84(a)
    1 ↔ 1
    1(56593869-56885594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.341292 Xenopus laevis transcribed sequence with weak similarity more 77.38(n)    BJ030905.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM958074.12   -- 76.93(n)    BM958074.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sick6
    sickie
    25(a)
    1 → many
    2L(19796365-19958424)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-536
    Protein UNC-53, isoform d (unc-53) mRNA, complete ...
    25(a)
    1 → many
    II(11058101-11089456) WBGene00006788


    ENSEMBL Gene Tree for NAV2 (if available)
    TreeFam Gene Tree for NAV2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
    About This Section

    Paralogs for NAV2 gene
    NAV12  NAV32  
    3 SIMAP similar genes for NAV2 using alignment to 5 protein entries:     NAV2_HUMAN (see all proteins):
    NAV3    NAV1    DKFZp434O2321

    Find genes that share paralogs with NAV2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and 4UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section


    Selected SNPs for NAV2 (see all 16887)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419842541,2
    Cuntested119995522(+) CATCTC/G/TCCTCA 10 S F mis11NA 4552
    rs595443071,2
    C--19057366(+) TGTGT-/GT    
       
    /GTGT
    ATGAA
    1 -- int10--------
    rs1424522391,2
    C--19092022(+) TTGGT-/AGA   
      GAGAAA
    ATGTG
    1 -- int10--------
    rs57900711,2
    C--19097719(+) TTTTT-/T/TT  
            
    CTGCT
    1 -- int10--------
    rs1998465171,2
    C--19097728(-) AAGCAA/GAAAAA 1 -- int10--------
    rs73954261,2
    C,F,A--19119290(+) accagT/Cccctg 1 -- int11Minor allele frequency- C:0.29EA 120
    rs73966461,2
    C,A--19119292(+) cagtcA/Cctgca 1 -- int10--------
    rs113019971,2
    C--19132035(+) ATCAAT/-TTTTT 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs632744621,2
    --19132035(+) ATCAAT/ATTTTT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs113999131,2
    C--19143044(+) CTCAG-/AAAAAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NAV2 (19372271 - 19622271 bp, first 250kb of NAV2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NAV2 (see all 41):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676711CNV Deletion23128226
    esv2667194CNV Deletion23128226
    esv1611893CNV Deletion17803354
    esv2744179CNV Deletion23290073
    esv2666507CNV Deletion23128226
    esv2289070CNV Deletion18987734
    esv2673508CNV Deletion23128226
    esv2397419CNV Deletion18987734
    esv2744180CNV Deletion23290073
    esv2664376CNV Deletion23128226

    Human Gene Mutation Database (HGMD): NAV2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAV2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
    About This Section

    OMIM gene information: 607026    OMIM disorders: --

    2 diseases for NAV2:    
    About MalaCards
    neuroblastoma 1    neuroblastoma

    1 inferred disease relationship from the University of Copenhagen DISEASES database for NAV2:
    Influenza

    Find genes that share disorders with NAV2           About GenesLikeMe

    Genetic Association Database (GAD): NAV2
    Human Genome Epidemiology (HuGE) Navigator: NAV2 (2 documents)

    Export disorders for NAV2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section


    PubMed articles for NAV2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with NAV2)

    1. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PubMed id 12079279)1, 2, 3 Maes T.... Buesa C. (Genomics 2002)
    2. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PubMed id 12062803)1, 2, 3 Coy J.F.... Poustka A. (Gene 2002)
    3. A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. (PubMed id 11904404)1, 2, 9 Merrill R.A.... Clagett-Dame M. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1, 4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (PubMed id 18937294)1, 4 Lasky-Su J....Faraone S.V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PubMed id 15158073)1, 2 Peeters P.J.... Moechars D.W.E. (Brain Res. Dev. Brain Res. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 89797 HGNC: 15997 AceView: NAV2 Ensembl:ENSG00000166833 euGenes: HUgn89797
    ECgene: NAV2 H-InvDB: NAV2

    (According to HUGE)
    About This Section
    HUGE: KIAA1419

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAV2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAV2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAV2 gene:
    Search GeneIP for patents involving NAV2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Clones from OriGene, GenScript, Sino Biological, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    About This Section


     
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