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NAV2 Gene

protein-coding GIFtS: 56

GC11P019691

neuron navigator 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 3.6.1.- ^³
FLJ10633 ^¹, ²
FLJ11030 ^¹, ²
FLJ23707 ^¹, ²
FLJ77876 ^²
HELAD1 ^¹, ², ³
KIAA1419 ^¹, ², ³, ⁵
POMFIL2 ^¹, ², ³
RAINB1 ^¹, ², ³, ⁵
STEERIN2 ^², ³
Steerin-2 ^³
UNC53H2 ^²
unc53H2 ^³

Descriptions
Helicase APC down-regulated 1 ^³
Pore membrane and/or filament-interacting-like protein 2 ^³
Retinoic acid inducible in neuroblastoma 1 ^³
Unc-53 homolog 2 ^³
helicase, APC down-regulated 1 ^²
neuron navigator 2 ^²
pore membrane and/or filament interacting like protein 2 ^²
retinoic acid inducible gene in neuroblastoma 1 ^²

External Ids
HGNC: 15997¹
Entrez Gene: 89797²
UniProtKB: Q8IVL1³
Ensembl: ENSG00000166833⁷

Search outside databases for aliases for NAV2 gene

Previous GC identifers: GC11P020896 GC11P020678 GC11P019411 GC11P019699

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAV2:

The vitamin A metabolite, all-trans retinoic acid (atRA), plays an important role in neuronal

development, including neurite outgrowth. RAINB1 is an atRA-responsive gene.[supplied by OMIM]

UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1

Function: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal

development, specifically in the development of different sensory organs

Gene Wiki entry for NAV2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAV2 gene

Entrez Gene cytogenetic band: 11p15.1 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.1

NAV2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P019691: (about GC identifiers)

Start:	19,691,457 bp from pter
End:	20,099,723 bp from pter
Size:	408,267 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_009237.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1 (See protein sequence)

Recommended Name: Neuron navigator 2

Size: 2488 amino acids; 268133 Da

Subcellular location: Nucleus

Developmental stage: Highly expressed in the nervous system of developing embryos. Also expressed

in fetal heart, liver and kidney

Caution: PubMed:15158073 experiments have been carried out in mouse

Sequence caution: Sequence=BAB85038.1; Type=Frameshift; Positions=2074;

PDB structures from and Proteopedia :

2YRN (3D)

Secondary accessions: Q8IVK3 Q8IVK4 Q8IVK5 Q8IVK6 Q8IVK7 Q8IVK8 Q8NHC9 Q8NHD0 Q8TDE9 Q8TDF0 Q8TEB3

Q96B30 Q9NUZ6 Q9NVM7 Q9P2C8

Alternative splicing: 13 isoforms: Q8IVL1-1 Q8IVL1-2 Q8IVL1-3 Q8IVL1-4 Q8IVL1-5 Q8IVL1-6 Q8IVL1-7 Q8IVL1-8

Q8IVL1-9 Q8IVL1-10 Q8IVL1-11 Q8IVL1-12 Q8IVL1-13 (Additional isoforms may exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001104488.1 NP_001104489.1 NP_660093.2 NP_892009.3

ENSEMBL proteins:

ENSP00000312169 ENSP00000379394 ENSP00000379396 ENSP00000353871 ENSP00000309577

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NAV2 / NAV3, NAV2)
	Human Recombinant Proteins from Abnova (NAV2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

Antibodies for NAV2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NAV2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NAV2 / NAV3, NAV2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NAV2)
	Novus Biologicals Antibodies for NAV2

Assays for NAV2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IVL1

ProtoNet protein and cluster: Q8IVL1

1 Blocks protein family: IPB001715 Calponin-like actin-binding

UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1

Similarity: Belongs to the Nav/unc-53 family

Similarity: Contains 1 CH (calponin-homology) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAV2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAV2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_145117

Applied Biosystems Silencer® siRNAs for NAV2

Sigma-Aldrich siRNA for NAV2

Sigma-Aldrich shRNA Panels and shRNA for NAV2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAV2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111018
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111018
untagged cDNA clones in CMV expression vector (see all 5): NM_001111018

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_182964

UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1

Function: Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal

development, specifically in the development of different sensory organs

Induction: By all-trans retinoic acid (atRA). Up-regulated in colorectal carcinomas

Enzyme Number (IUBMB): EC 3.6.1.-

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nav2):

behavior/neurological	growth/size	hearing/vestibular/ear	nervous system	taste/olfaction
touch/vibrissae	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004386	helicase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016787	hydrolase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAV2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAV2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAV2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_145117

Sigma-Aldrich siRNA for NAV2

Sigma-Aldrich shRNA Panels and shRNA for NAV2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001111018 NM_001111019 NM_145117 NM_182964

REFSEQ mRNAs for NAV2 gene (4 alternative transcripts):

NM_001111018.1 NM_001111019.1 NM_145117.4 NM_182964.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001111018 NM_001111019 NM_145117 NM_182964

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001111018
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001111018
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001111018

Additional cDNA sequence: AJ488202.1

21 DOTS entries:

DT.100785395 DT.406815 DT.445168 DT.100699961 DT.100693170 DT.100785398 DT.100023051 DT.100640016

DT.92058282 DT.100721645 DT.421264 DT.100693167 DT.117695 DT.120702225 DT.95273461 DT.120702063

DT.120702137 DT.40239601 DT.91711310 DT.91894626 DT.97823709

24/47 AceView cDNA sequences (see all 47 ):

AI739417 AJ488205 AJ488208 M79074 AA984260 BM800972 BX485661 BM714992

AA150056 BX502578 BQ431205 AA152178 AL699569 BG763937 BX502564 AA037745

BM676695 CD654605 BU739339 BG924941 BF511334 CD691701 BF511191 T24445

highest scoring ESTs for NAV2:

AA708740 AI971541 AA011020 AA042824 AA042992 AA115015 AA150056 AA256661 AA451836 AA493555

Unigene Clusters for NAV2:

Neuron navigator 2

Hs.502116 [show with all ESTs], Hs.551898 [show with all ESTs], Hs.639427 , Hs.639428

Unigene Representative Sequences: NM_182964, BG924941, AJ488204, AJ488202

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NAV2 (see all 8 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24	^	25a	·
SP1:																																																			-
SP2:			-		-
SP3:
SP4:
SP5:					-

ExUns:	25b	^	26	^	27a	·	27b	^	28a	·	28b
SP1:					-
SP2:
SP3:
SP4:					-
SP5:

About this scheme

ECgene alternative splicing isoforms for NAV2

5 Ensembl transcripts including schematic representations:

ENST00000311043 ENST00000396085 ENST00000396087 ENST00000360655 ENST00000349880

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAV2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAV2

¹ / ² / ³

11 probe-sets matching NAV2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44057_at²^{, 3}	U95-B	1	1.00	1.00	0.83	1.53	AA708740	1.00	1.00	1.00	1
58506_at²^{, 3}	U95-B	1	1.00	1.00	0.85	0.91	R52158	0.80	1.00	0.91	1
51398_at²^{, 3}	U95-B	1	1.00	1.00	0.73	0.49	AA150056	0.80	1.00	0.91	1
90308_at²^{, 3}	U95-E	2	1.00	0.72	0.48	1.09	AI971541	1.00	1.00	1.00	1
218330_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018162	0.20	1.00	0.72	1
222599_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AU137607	0.80	1.00	0.91	1
222598_s_at²^{, 3}	U133-B	2	1.00	0.50	--	--	AK001892	0.80	1.00	0.91	1
1567358_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218330_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222599_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222598_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

GeneDecks NAV2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.502116 Hs.551898 Hs.639427 Hs.639428
UniProtKB/Swiss-Prot: NAV2_HUMAN, Q8IVL1
Tissue specificity: Highly expressed in the brain, kidney and liver. Also expressed in the thyroid,
mammary gland, spinal cord, heart, placenta and lung. Abundantly expressed in colon cancers

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAV2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAV2¹	--	neuron navigator 2	90.82(n) 95.92(a)	485411 XM_542530.2 XP_542530.2
chimpanzee (Pan troglodytes)	NAV2¹	--	neuron navigator 2	99.51(n) 99.75(a)	451076 XM_001173746.1 XP_001173746.1
rat (Rattus norvegicus)	Nav2¹	--	neuron navigator 2	87.77(n) 93.88(a)	171563 XM_341864.3 XP_341865.3
mouse (Mus musculus)	Nav2⁵	7	neuron navigator 2	--	DV652788
chicken (Gallus gallus)	NAV2¹	--	neuron navigator 2	78.96(n) 86.89(a)	422977 XM_420909.2 XP_420909.2

About this table Species with no ortholog for NAV2

ENSEMBL Gene Tree for NAV2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NAV2 gene

NAV1² NAV3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/2554 NCBI SNPs in NAV2 are shown (see all 2554 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 1097)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2246192^1,2	A,C,F,H,O	20098415(-)	`TGAGAC/TTAAAG`	4	--	ut3¹		13	EA NA EU WA	2528
	rs894445^1,2	A,C,F,H,O	20097047(-)	`TGGTTC/TGATTG`	4	--	ut3¹ ese³		9	MN EA NA EU WA	812
	rs3802803^1,2	A,C,F,H	20096513(+)	`ACCCCC/TCGTCC`	4	--	ut3¹ ese³		4	EU EA WA	412
	rs6483617^1,2	A,C,F,H	19810664(+)	`CATCAG/AGGATC`	3	K/R	mis¹		12	EU EA WA	1252
	rs10833249^1,2	A,C,F,H	20097990(+)	`AGCTGA/GCAACC`	4	--	ut3¹ ese³		4	EU EA WA	412
--	rs10833248^1,2	A,C,F,H	20096963(+)	`CAGGGG/AAACCT`	4	--	ut3¹		7	NA MN EA WA	586
	rs3802800^1,2	A,C,F,H	20022355(+)	`CGAAGG/CCTTCA`	4	A/P	mis¹ ese³		13	EA NA EU WA	2516
	rs3802799^1,2	A,C,F,H	20022249(+)	`GACGAG/TTCCGA`	4	E/D	mis¹ ese³		14	EA NA EU WA	2610
	rs16937251^1,2	C,F,H	19911770(+)	`GCCCAG/CAGGAC`	3	H/Q	mis¹ ese³		11	NA EU EA WA	936
	rs11025395^1,2	C,F,H	20096931(+)	`GGTCAC/TGTTCA`	4	--	ut3¹ ese³		8	EU EA WA	838

About this table

HapMap Linkage Disequilibrium images for NAV2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607026

Human Gene Mutation Database: NAV2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/20 PubMed articles for NAV2 gene (see all 20 ):

Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PubMed id 12079279)^{2, 3, 4} Maes T.... Buesa C. (2002)
Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PubMed id 12062803)^{2, 3, 4} Coy J.F....Poustka A. (2002)
A mammalian homolog of unc-53 is regulated by all-trans retinoic acid in neuroblastoma cells and embryos. (PubMed id 11904404)^{1, 3, 4} Merrill R.A.... Clagett-Dame M. (2002)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PubMed id 15158073)^{3, 4} Peeters P.J.... Moechars D.W.E. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas. (PubMed id 12214280)^{3, 4} Ishiguro H.... Furukawa Y. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 89797	HGNC: 15997	AceView: NAV2	Ensembl:ENSG00000166833	euGenes: HUgn89797
ECgene: NAV2	H-InvDB: NAV2

(According to HUGE)
About This Section

HUGE: KIAA1419

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NAV2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NAV2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NAV2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAV2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAV2		Antibodies for NAV2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAV2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAV2)
	Antibodies (NAV2)
	Chimera RNAi (NAV2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (NAV2 / NAV3, NAV2)
	Antibodies (NAV2 / NAV3, NAV2)

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Search Tocris compounds for NAV2

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Antibodies for NAV2

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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NAV2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for NAV2

Summaries
for NAV2

Genomic Location
for NAV2

Proteins
for NAV2

Protein Domains/
Families
for NAV2

Gene Function
for NAV2

Pathways & Interactions
for NAV2

Drugs & Compounds
for NAV2

Transcripts
for NAV2

Expression
for NAV2

Orthologs
for NAV2

Paralogs
for NAV2

SNPs/Variants
for NAV2

Disorders & Mutations
for NAV2

Medical News
for NAV2

Publications
for NAV2

Search for NAV2

Genome Databases showing NAV2

Other Databases showing NAV2

Specialized Databases showing NAV2

Licensable Technologies
for NAV2

Services
for NAV2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAV2 (Gene Symbol)
EC 3.6.1.-
FLJ10633
FLJ11030
FLJ23707
FLJ77876
HELAD1
KIAA1419
POMFIL2
RAINB1
STEERIN2
Steerin-2
UNC53H2
unc53H2
Helicase APC down-regulated 1
Pore membrane and/or filament-interacting-like protein 2
Retinoic acid inducible in neuroblastoma 1
Unc-53 homolog 2
helicase, APC down-regulated 1
neuron navigator 2
pore membrane and/or filament interacting like protein 2
retinoic acid inducible gene in neuroblastoma 1

NAV2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor NAV2

Summariesfor NAV2

Genomic Locationfor NAV2

Proteinsfor NAV2

Protein Domains/Familiesfor NAV2

Gene Functionfor NAV2

Pathways & Interactionsfor NAV2

Drugs & Compoundsfor NAV2

Transcriptsfor NAV2

Expression for NAV2

Orthologsfor NAV2

Paralogsfor NAV2

SNPs/Variantsfor NAV2

Disorders & Mutationsfor NAV2

Medical Newsfor NAV2

Publicationsfor NAV2

Search for NAV2

Genome Databases showing NAV2

Other Databases showing NAV2

Specialized Databases showing NAV2

Licensable Technologiesfor NAV2

Servicesfor NAV2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAV2

Summaries
for NAV2

Genomic Location
for NAV2

Proteins
for NAV2

Protein Domains/
Families
for NAV2

Gene Function
for NAV2

Pathways & Interactions
for NAV2

Drugs & Compounds
for NAV2

Transcripts
for NAV2

Expression
for NAV2

Orthologs
for NAV2

Paralogs
for NAV2

SNPs/Variants
for NAV2

Disorders & Mutations
for NAV2

Medical News
for NAV2

Publications
for NAV2

Licensable Technologies
for NAV2

Services
for NAV2