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NAV1 Gene

protein-coding   GIFtS: 52
GCID: GC01P201595

Neuron Navigator 1

  Search for NAV1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neuron Navigator 11 2     STEERIN12 3
POMFIL32 3 5     KIAA11513 5
Neuron Navigator-11 2     UNC53H12
Pore Membrane And/Or Filament Interacting Like Protein 31 2     KIAA12133
Pore Membrane And/Or Filament-Interacting-Like Protein 32 3     Steerin-13
Unc-53 Homolog 12 3     unc53H13

External Ids:    HGNC: 159891   Entrez Gene: 897962   Ensembl: ENSG000001343697   OMIM: 6116285   UniProtKB: Q8NEY13   

Export aliases for NAV1 gene to outside databases

Previous GC identifers: GC01P199392 GC01P197115 GC01P198083 GC01P198905 GC01P198349 GC01P199859 GC01P199884 GC01P172783


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAV1 Gene:
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded
protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a
variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon
guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal
development and regeneration. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Nov 2009)

GeneCards Summary for NAV1 Gene:
NAV1 (neuron navigator 1) is a protein-coding gene. GO annotations related to this gene include nucleoside-triphosphatase activity and nucleotide binding. An important paralog of this gene is NAV3.

UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1
Function: May be involved in neuronal migration (By similarity)

Gene Wiki entry for NAV1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAV1 gene promoter:
         Egr-3   GR   NF-1   Egr-1   GR-beta   AP-4   HNF-4alpha1   MZF-1   AREB6   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAV1 promoter sequence
   Search Chromatin IP Primers for NAV1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAV1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.3

NAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAV1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P201595:  view genomic region     (about GC identifiers)

Start:
201,592,411 bp from pter      End:
201,796,102 bp from pter
Size:
203,692 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1 (See protein sequence)
Recommended Name: Neuron navigator 1  
Size: 1877 amino acids; 202472 Da
Subunit: Interacts with tubulin (By similarity)
Developmental stage: Expressed in fetal brain and heart
Sequence caution: Sequence=AAH07523.1; Type=Erroneous initiation; Sequence=BAB14136.1; Type=Erroneous initiation;
Sequence=BAB14142.1; Type=Erroneous initiation; Sequence=BAB14865.1; Type=Erroneous initiation;
Sequence=CAH71925.1; Type=Erroneous gene model prediction; Sequence=CAI17010.1; Type=Erroneous gene model
prediction;
Secondary accessions: A8MS88 Q5SVH1 Q5SVH2 Q5SVH3 Q5SVH7 Q5VUY9 Q8IVL2 Q96II1 Q9H7V9 Q9H9S9
Q9H9T5 Q9UGI1 Q9ULK7 Q9ULR9
Alternative splicing: 7 isoforms:  Q8NEY1-1   Q8NEY1-2   Q8NEY1-3   Q8NEY1-4   Q8NEY1-5   Q8NEY1-6   Q8NEY1-7   

Explore the universe of human proteins at neXtProt for NAV1: NX_Q8NEY1

Explore proteomics data for NAV1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NAV1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161210.1  NP_065176.3  

    ENSEMBL proteins: 
     ENSP00000356271   ENSP00000356265   ENSP00000356264   ENSP00000405437   ENSP00000389123  
     ENSP00000426436   ENSP00000295624   ENSP00000356266   ENSP00000356269  

    NAV1 Human Recombinant Protein Products:

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    Novus Biologicals NAV1 Protein
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    Cloud-Clone Corp. Proteins for NAV1

     
    Search eBioscience for Proteins for NAV1 

    NAV1 Antibody Products:

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    Novus Biologicals NAV1 Antibodies
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    NAV1 Assay Products:

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    Cloud-Clone Corp. ELISAs for NAV1
    Cloud-Clone Corp. CLIAs for NAV1
    Search eBioscience for ELISAs for NAV1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q8NEY1

    ProtoNet protein and cluster: Q8NEY1

    1 Blocks protein domain: IPB008162 Inorganic pyrophosphatase

    UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1
    Similarity: Belongs to the Nav/unc-53 family


    Find genes that share domains with NAV1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAV1_HUMAN, Q8NEY1
    Function: May be involved in neuronal migration (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    Find genes that share ontologies with NAV1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NAV1:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAV1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAV1
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    miRNA
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    miRTarBase miRNAs that target NAV1:
    hsa-mir-9-5p (MIRT021353), hsa-mir-7-5p (MIRT047773)

    Block miRNA regulation of human, mouse, rat NAV1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAV1 (see all 151):
    hsa-miR-576-3p hsa-miR-631 hsa-miR-1914* hsa-miR-1260b hsa-miR-877* hsa-miR-409-5p hsa-miR-3622b-3p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NAV1
    Predesigned siRNA for gene silencing in human, mouse, rat NAV1

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAV1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NAV1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAV1_HUMAN, Q8NEY1: Cytoplasm, cytoskeleton (By similarity). Note=Associates with a subset of microtubule plus
    ends. Enriched in neuronal growth cones (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    nucleus3
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0015630microtubule cytoskeleton ----

    Find genes that share ontologies with NAV1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAV1
    Interactions:

        Search GeneGlobe Interaction Network for NAV1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for NAV1 (Q8NEY13 ENSP000002956244) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    TBC1D4O603433, ENSP000003668634I2D: score=2 STRING: ENSP00000366863
    YWHAEP622583I2D: score=1 
    UFL1ENSP000003582834STRING: ENSP00000358283
    CLUHENSP000003888724STRING: ENSP00000388872
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001578microtubule bundle formation IEA--
    GO:0001764neuron migration IEA--

    Find genes that share ontologies with NAV1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAV1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAV1 gene (2 alternative transcripts): 
    NM_001167738.1  NM_020443.4  

    Unigene Cluster for NAV1:

    Neuron navigator 1
    Hs.585374  [show with all ESTs]
    Unigene Representative Sequence: NM_020443
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000491403 ENST00000367302 ENST00000367296(uc021phi.1) ENST00000490213(uc001gwv.1)
    ENST00000367295(uc001gww.2 uc001gwx.3) ENST00000430015 ENST00000469130(uc001gwy.1)
    ENST00000438083 ENST00000477118 ENST00000295624(uc001gwu.3) ENST00000367297
    ENST00000367300
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAV1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAV1 (see all 151):
    hsa-miR-576-3p hsa-miR-631 hsa-miR-1914* hsa-miR-1260b hsa-miR-877* hsa-miR-409-5p hsa-miR-3622b-3p hsa-miR-298
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NAV1
    Predesigned siRNA for gene silencing in human, mouse, rat NAV1
    Clone
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    OriGene clones in human, mouse for NAV1 (see all 10)
    OriGene ORF clones in mouse, rat for NAV1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for NAV1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAV1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NAV1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAV1
      QuantiTect SYBR Green Assays in human, mouse, rat NAV1
      QuantiFast Probe-based Assays in human, mouse, rat NAV1

    Additional mRNA sequence: 

    AB032977.3 AB033039.1 AF086348.1 AJ488101.1 AK022622.1 AK022631.1 AK024265.1 AK056158.1 
    AK091567.1 AL133664.1 AY043013.1 BC007523.1 BC069250.1 BC117683.1 BX648460.1 CR936811.1 

    22 DOTS entries:

    DT.95311045  DT.95143036  DT.100017088  DT.205340  DT.101983412  DT.121338801  DT.95343066  DT.95131868 
    DT.100794609  DT.40299118  DT.91826624  DT.95086544  DT.87046235  DT.91710046  DT.121338860  DT.91954325 
    DT.75169939  DT.86841911  DT.95311047  DT.40112361  DT.75110211  DT.97824207 

    Selected AceView cDNA sequences (see all 293):

    BQ447636 AF086348 T33464 AI375880 AU131723 AW291468 AW051342 BF726624 
    BU742933 BM681112 AA411669 BM549511 AA128315 BQ185652 Z44991 AL571395 
    AL133664 AI272296 AI379115 Z45977 AK022622 CA437100 BX478788 BU179305 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAV1 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
    SP1:                                                                                                                                                  -         
    SP2:                                                                                                                                                            
    SP3:                          -                                                                                                                                 
    SP4:                                                                                                                                                            
    SP5:                    -     -                                                                                                                                 

    ExUns: 22 ^ 23
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for NAV1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAV1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCCTCCCA
    NAV1 Expression
    About this image


    NAV1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             N2/LSB induced-cells
     
     Neural Tube (Nervous System)
             Metencephalon
    NAV1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAV1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585374

    UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1
    Tissue specificity: Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and
    placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NAV1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nav11 , 5 neuron navigator 11, 5 90.05(n)1
    96.37(a)1
      1 (58.79 cM)5
    2156901  NM_173437.21  NP_775613.21 
     1354345805 
    chicken
    (Gallus gallus)
    Aves NAV11 neuron navigator 1 79.61(n)
    87.18(a)
      430162  XM_004934835.1  XP_004934892.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAV16
    neuron navigator 1
    85(a)
    1 ↔ 1
    4(132003597-132043808)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nav11 neuron navigator 1 65.64(n)
    70.57(a)
      100495951  XM_002932137.2  XP_002932183.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000050001 neuron navigator 1-like 65.46(n)
    64.75(a)
      100005000  XM_005166158.1  XP_005166215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sick6
    sickie
    19(a)
    1 → many
    2L(19796365-19958424)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-536
    Protein UNC-53, isoform d (unc-53) mRNA, complete ...
    21(a)
    1 → many
    II(11058101-11089456) WBGene00006788


    ENSEMBL Gene Tree for NAV1 (if available)
    TreeFam Gene Tree for NAV1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAV1 gene
    NAV32  NAV22  
    3 SIMAP similar genes for NAV1 using alignment to 5 protein entries:     NAV1_HUMAN (see all proteins):
    DKFZp434O2321    NAV2    NAV3

    Find genes that share paralogs with NAV1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAV1 (see all 3490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6594701,2
    C,F,A,H--201615519(+) ATGTCT/CGTCTA 1 -- us2k125Minor allele frequency- C:0.28MN NS EA NA WA CSA 2539
    rs1901379381,2
    --201615615(+) TTGTAC/TTCCCT 1 -- us2k10--------
    rs1418479661,2
    --201615666(+) AGAATC/TGCCAC 1 -- us2k10--------
    rs1165714811,2
    C,F--201615744(+) ACTCTA/GTATTC 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1507855891,2
    --201615923(+) AACACC/TTGCTC 1 -- us2k10--------
    rs751999931,2
    C,F--201615982(+) CTGGCG/AGGGGA 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1159819151,2
    C,F--201616132(+) GTTGGG/ATTTGG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1821932581,2
    --201616157(+) CTGATA/GGTTAG 1 -- us2k10--------
    rs793847861,2
    C,F--201616188(+) TAGGGC/GTTTAT 1 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1396972561,2
    C--201616329(+) AGGATA/GGGCAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAV1 (201592411 - 201796102 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NAV1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721495CNV Deletion23290073
    esv2666987CNV Deletion23128226
    esv2721506CNV Deletion23290073
    esv2676669CNV Deletion23128226
    nsv826187CNV Loss20364138
    nsv818766CNV Loss17921354
    esv1632559OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): NAV1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAV1
    DNA2.0 Custom Variant and Variant Library Synthesis for NAV1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 611628    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NAV1:
    Brugada syndrome

    Find genes that share disorders with NAV1           About GenesLikeMe

    Genetic Association Database (GAD): NAV1

    Export disorders for NAV1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NAV1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with NAV1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PubMed id 12079279)1, 2, 3 Maes T.... Buesa C. (Genomics 2002)
    2. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PubMed id 12062803)1, 2, 3 Coy J.F.... Poustka A. (Gene 2002)
    3. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PubMed id 15158073)1, 2 Peeters P.J.... Moechars D.W.E. (Brain Res. Dev. Brain Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (DNA Res. 1999)
    6. A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease. (PubMed id 23936387)1 A9stensson M....Torinsson-Naluai A.8. (PLoS ONE 2013)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 89796 HGNC: 15989 AceView: NAV1 Ensembl:ENSG00000134369 euGenes: HUgn89796
    ECgene: NAV1 H-InvDB: NAV1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1151 KIAA1213

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAV1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NAV1 gene:
    Search GeneIP for patents involving NAV1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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