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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NAV1 Gene

protein-coding GIFtS: 50
GCID: GC01P201595

neuron navigator 1

Explore 3 diseases affiliated with
NAV1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neuron Navigator 1¹ ²		MGC14961¹
POMFIL3¹ ² ³ ⁵		Steerin-1³
KIAA1151¹ ³ ⁵		UNC53H1²
Pore Membrane And/Or Filament-Interacting-Like Protein 3² ³		Neuron Navigator-1²
Unc-53 Homolog 1² ³		Pore Membrane And/Or Filament Interacting Like Protein 3²
STEERIN1² ³		KIAA1213³
DKFZp781D0314¹		Steerin-1³
FLJ12560¹		Unc53H1¹
FLJ14203¹

External Ids:	HGNC: 15989¹	Entrez Gene: 89796²	Ensembl: ENSG00000134369⁷	OMIM: 611628⁵	UniProtKB: Q8NEY1³

Export aliases for NAV1 gene to outside databases

Previous GC identifers: GC01P199392 GC01P197115 GC01P198083 GC01P198905 GC01P198349 GC01P199859 GC01P199884 GC01P172783

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAV1:

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded

protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety

of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The

exact function of this gene is not known, but it is thought to play a role in in neuronal development and

regeneration. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov 2009)

UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1

Function: May be involved in neuronal migration (By similarity)

Gene Wiki entry for NAV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NAV1 gene promoter:
Egr-3 GR NF-1 Egr-1 GR-beta AP-4 HNF-4alpha1 MZF-1 AREB6 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAV1 promoter sequence

Search SABiosciences Chromatin IP Primers for NAV1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAV1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.3

NAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAV1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P201595: view genomic region (about GC identifiers)

Start:	201,592,411 bp from pter	End:	201,796,102 bp from pter
Size:	203,692 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1 (See protein sequence)

Recommended Name: Neuron navigator 1

Size: 1877 amino acids; 202472 Da

Subunit: Interacts with tubulin (By similarity)

Subcellular location: Cytoplasm, cytoskeleton (By similarity). Note=Associates with a subset of microtubule plus ends.

Enriched in neuronal growth cones (By similarity)

Developmental stage: Expressed in fetal brain and heart

Sequence caution: Sequence=AAH07523.1; Type=Erroneous initiation; Sequence=BAB14136.1; Type=Erroneous initiation;

Sequence=BAB14142.1; Type=Erroneous initiation; Sequence=BAB14865.1; Type=Erroneous initiation; Sequence=CAH71925.1;

Type=Erroneous gene model prediction; Sequence=CAI17010.1; Type=Erroneous gene model prediction;

Secondary accessions: A8MS88 Q5SVH1 Q5SVH2 Q5SVH3 Q5SVH7 Q5VUY9 Q8IVL2 Q96II1 Q9H7V9 Q9H9S9 Q9H9T5

Q9UGI1 Q9ULK7 Q9ULR9

Alternative splicing: 7 isoforms: Q8NEY1-1 Q8NEY1-2 Q8NEY1-3 Q8NEY1-4 Q8NEY1-5 Q8NEY1-6 Q8NEY1-7

Explore the universe of human proteins at neXtProt for NAV1: NX_Q8NEY1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NEY1

NAV1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161210.1 NP_065176.3

ENSEMBL proteins:

ENSP00000356271 ENSP00000356265 ENSP00000356264 ENSP00000405437 ENSP00000389123

ENSP00000426436 ENSP00000295624 ENSP00000356266 ENSP00000356269

Human Recombinant Protein Products for NAV1:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	GenScript Custom Purified and Recombinant Proteins Services for NAV1
	Novus Biologicals NAV1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NAV1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005874	microtubule	IEA	--
GO:0015630	microtubule cytoskeleton	--	--

NAV1 for ontologies About GeneDecksing

NAV1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NAV1
	Browse R&D Systems for Antibodies
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	GenScript Custom Superior Antibodies Services for NAV1
	Novus Biologicals NAV1 Antibodies
	Abcam antibodies for NAV1
	Uscn Antibodies for NAV1
	Search ThermoFisher Antibodies for NAV1

Assay Products for NAV1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NAV1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NAV1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NAV1 for domains About GeneDecksing

1 InterPro domain/family:

IPR003593 AAA+_ATPase

Graphical View of Domain Structure for InterPro Entry Q8NEY1

ProtoNet protein and cluster: Q8NEY1

1 Blocks protein family: IPB008162 Inorganic pyrophosphatase

UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1

Similarity: Belongs to the Nav/unc-53 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NAV1_HUMAN, Q8NEY1

Function: May be involved in neuronal migration (By similarity)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0017111	nucleoside-triphosphatase activity	IEA	--

NAV1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NAV1:

Decreased viability with pacli

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NAV1

miRNA Products:		OriGene 3'-UTR Clone: NAV1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAV1
		8/151 QIAGEN miScript miRNA Assays for microRNAs that regulate NAV1 (see all 151):
		hsa-miR-576-3p hsa-miR-631 hsa-miR-1914* hsa-miR-1260b hsa-miR-877* hsa-miR-409-5p hsa-miR-3622b-3p hsa-miR-298

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAV1 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAV1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NAV1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NAV1
			Sirion Biotech Customized adenovirus for overexpression of NAV1 Sirion Biotech Customized adenovirus for potent knockdown of NAV1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAV1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAV1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for NAV1
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAV1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NAV1
		Search LifeMap BioReagents cell lines for NAV1
		Sirion Biotech Customized stable knockdown cell line services for NAV1 Sirion Biotech Customized inducible knockdown cell line services for NAV1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NAV1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for NAV1 (Q8NEY1³ ENSP00000295624⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APC	P25054³, ENSP00000257430⁴	I2D: score=3 STRING: ENSP00000257430
TBC1D4	O60343³, ENSP00000366863⁴	I2D: score=2 STRING: ENSP00000366863
YWHAE	P62258³	I2D: score=1
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001578	microtubule bundle formation	IEA	--
GO:0001764	neuron migration	IEA	--

NAV1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NAV1
Search CenterWatch for drugs/clinical trials and news about NAV1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NAV1 gene (2 alternative transcripts):

NM_001167738.1 NM_020443.4

Unigene Cluster for NAV1:

Neuron navigator 1

Hs.585374 [show with all ESTs]

Unigene Representative Sequence: NM_020443

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000491403 ENST00000367302 ENST00000367296(uc021phi.1) ENST00000490213(uc001gwv.1)

ENST00000367295(uc001gww.2 uc001gwx.3) ENST00000430015 ENST00000469130(uc001gwy.1)

ENST00000438083 ENST00000477118 ENST00000295624(uc001gwu.3) ENST00000367297

ENST00000367300

miRNA Products:		OriGene 3'-UTR Clone: NAV1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAV1
		8/151 QIAGEN miScript miRNA Assays for microRNAs that regulate NAV1 (see all 151):
		hsa-miR-576-3p hsa-miR-631 hsa-miR-1914* hsa-miR-1260b hsa-miR-877* hsa-miR-409-5p hsa-miR-3622b-3p hsa-miR-298

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAV1 (see all 3) Browse OriGene siRNA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAV1
		Sirion Biotech Custom design and validation of potent shRNA sequences against NAV1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAV1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAV1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for NAV1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAV1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAV1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAV1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NAV1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAV1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAV1

Additional cDNA sequence:

AB032977.3 AB033039.1 AF086348.1 AJ488101.1 AK022622.1 AK022631.1 AK024265.1 AK056158.1

AK091567.1 AL133664.1 AY043013.1 BC007523.1 BC069250.1 BC117683.1 BX648460.1 CR936811.1

22 DOTS entries:

DT.95311045 DT.95143036 DT.100017088 DT.205340 DT.101983412 DT.121338801 DT.95343066 DT.95131868

DT.100794609 DT.40299118 DT.91826624 DT.95086544 DT.87046235 DT.91710046 DT.121338860 DT.91954325

DT.75169939 DT.86841911 DT.95311047 DT.40112361 DT.75110211 DT.97824207

24/293 AceView cDNA sequences (see all 293):

AI199773 BU742921 Z41591 BE219474 AI870494 AI272296 AA233277 BE326555

CB159133 AK022622 AL571395 AA043878 AL133664 Z45977 AI379115 BU731888

CA437100 BU179305 BM052858 BX478788 BQ213563 AI754668 AA486151 AI014889

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NAV1 (see all 7) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^	19	^	20a	·	20b	^	21	^
SP1:																																																	-
SP2:
SP3:									-
SP4:
SP5:							-		-

ExUns:	22	^	23
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NAV1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NAV1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCCTCCCA

About this image

NAV1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

N2/LSB induced-cells (Generation of midbra...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NAV1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAV1

SOURCE GeneReport for Unigene cluster: Hs.585374

UniProtKB/Swiss-Prot: NAV1_HUMAN, Q8NEY1

Tissue specificity: Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta

SABiosciences Custom PCR Arrays for NAV1

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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NAV1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAV1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAV1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAV1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NAV1 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NAV1¹	neuron navigator 1	79.94(n) 87.63(a)		430162 XM_427719.3 XP_427719.3
lizard (Anolis carolinensis)	Reptilia	NAV1⁶	--	85(a)	1 ↔ 1	4(132003597-132043808)
zebrafish (Danio rerio)	Actinopterygii	nav1¹	neuron navigator 1	64.49(n) 64.32(a)		100536287 XM_003201170.1 XP_003201218.1
fruit fly (Drosophila melanogaster)	Insecta	sick⁶	sickie	14(a)	1 → many	2L(19796365-19958424)
worm (Caenorhabditis elegans)	Secernentea	unc-53⁶	Adapter protein unc-53	17(a)	1 → many	II(11058043-11089398)

ENSEMBL Gene Tree for NAV1 (if available)
TreeFam Gene Tree for NAV1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NAV1 gene

NAV3² NAV2²

3 SIMAP similar genes for NAV1 using alignment to 5 protein entries: NAV1_HUMAN (see all proteins):

DKFZp434O2321 NAV2 NAV3

NAV1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs659470^1,2	C,F,A,H	--	201615519(+)	`ATGTCT/CGTCTA`	1	--	us2k¹		25		MN NS EA NA WA CSA	2539
rs190137938^1,2		--	201615615(+)	`TTGTAC/TTCCCT`	1	--	us2k¹		0	--	--	--	--
rs141847966^1,2		--	201615666(+)	`AGAATC/TGCCAC`	1	--	us2k¹		0	--	--	--	--
rs116571481^1,2		--	201615744(+)	`ACTCTA/GTATTC`	1	--	us2k¹		1		NA	120
rs150785589^1,2		--	201615923(+)	`AACACC/TTGCTC`	1	--	us2k¹		0	--	--	--	--
rs75199993^1,2	C,F	--	201615982(+)	`CTGGCG/AGGGGA`	1	--	us2k¹		1		WA	118
rs115981915^1,2		--	201616132(+)	`GTTGGG/ATTTGG`	1	--	us2k¹		1		NA	120
rs182193258^1,2		--	201616157(+)	`CTGATA/GGTTAG`	1	--	us2k¹		0	--	--	--	--
rs79384786^1,2		--	201616188(+)	`TAGGGC/GTTTAT`	1	--	us2k¹		1		NA	120
rs139697256^1,2		--	201616329(+)	`AGGATA/GGGCAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NAV1 (201592411 - 201796102 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NAV1
1 CNV: 9912

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAV1

DNA2.0 Custom Variant and Variant Library Synthesis for NAV1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NAV1 for disorders           About GeneDecksing

OMIM gene information: 611628    OMIM disorders: --

3 diseases for NAV1:    About MalaCards

neuronitis erythromelalgia influenza

1 disease from the University of Copenhagen DISEASES database for NAV1:

Brugada syndrome

Export disorders for NAV1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NAV1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with NAV1)

Utopia: connect your pdf to the dynamic
world of online information

Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PubMed id 12079279)^{1, 2, 3} Maes T.... Buesa C. (2002)
Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PubMed id 12062803)^{1, 2, 3} Coy J.F....Poustka A. (2002)
Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PubMed id 15158073)^{1, 2} Peeters P.J.... Moechars D.W.E. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{1, 2} Hirosawa M.... Ohara O. (1999)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89796	HGNC: 15989	AceView: NAV1	Ensembl:ENSG00000134369	euGenes: HUgn89796
ECgene: NAV1	H-InvDB: NAV1

(According to HUGE)
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HUGE: KIAA1151 KIAA1213

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NAV1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NAV1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NAV1 gene:
Search GeneIP for patents involving NAV1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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NAV1 Gene

neuron navigator 1

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NAV1 Gene

neuron navigator 1

Aliasesfor NAV1 gene

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Functionfor NAV1 gene

Pathways & Interactionsfor NAV1 gene

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for NAV1 gene

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for NAV1 gene

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for NAV1 gene

Pathways & Interactions
for NAV1 gene

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for NAV1 gene

Transcripts
for NAV1 gene

Expression
for NAV1 gene

Orthologs
for NAV1 gene

Paralogs
for NAV1 gene

Genomic Variants
for NAV1 gene

Disorders / Diseases
for NAV1 gene

Publications
for NAV1 gene

Intellectual Property
for NAV1 gene

Products
for NAV1 gene