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Aliases for NAV1 Gene

Aliases for NAV1 Gene

  • Neuron Navigator 1 2 3
  • POMFIL3 3 4 6
  • Pore Membrane And/Or Filament Interacting Like Protein 3 2 3
  • Pore Membrane And/Or Filament-Interacting-Like Protein 3 3 4
  • Neuron Navigator-1 2 3
  • Unc-53 Homolog 1 3 4
  • STEERIN1 3 4
  • KIAA1151 4 6
  • UNC53H1 3 4
  • Steerin-1 4
  • KIAA1213 4

External Ids for NAV1 Gene

Summaries for NAV1 Gene

Entrez Gene Summary for NAV1 Gene

  • This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

GeneCards Summary for NAV1 Gene

NAV1 (Neuron Navigator 1) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and nucleoside-triphosphatase activity. An important paralog of this gene is NAV3.

UniProtKB/Swiss-Prot for NAV1 Gene

  • May be involved in neuronal migration.

Gene Wiki entry for NAV1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAV1 Gene

Genomics for NAV1 Gene

Genomic Location for NAV1 Gene

Start:
201,539,336 bp from pter
End:
201,826,974 bp from pter
Size:
287,639 bases
Orientation:
Plus strand

Genomic View for NAV1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAV1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAV1 Gene

Regulatory Elements for NAV1 Gene

Proteins for NAV1 Gene

  • Protein details for NAV1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEY1-NAV1_HUMAN
    Recommended name:
    Neuron navigator 1
    Protein Accession:
    Q8NEY1
    Secondary Accessions:
    • A8MS88
    • Q5SVH1
    • Q5SVH2
    • Q5SVH3
    • Q5SVH7
    • Q5VUY9
    • Q8IVL2
    • Q96II1
    • Q9H7V9
    • Q9H9S9
    • Q9H9T5
    • Q9UGI1
    • Q9ULK7
    • Q9ULR9

    Protein attributes for NAV1 Gene

    Size:
    1877 amino acids
    Molecular mass:
    202472 Da
    Quaternary structure:
    • Interacts with tubulin.
    SequenceCaution:
    • Sequence=AAH07523.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14136.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14142.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14865.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH71925.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI17010.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NAV1 Gene

neXtProt entry for NAV1 Gene

Proteomics data for NAV1 Gene at MOPED

Post-translational modifications for NAV1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAV1 Gene

Domains for NAV1 Gene

Protein Domains for NAV1 Gene

UniProtKB/Swiss-Prot:

NAV1_HUMAN
Family:
  • Belongs to the Nav/unc-53 family.:
    • Q8NEY1
genes like me logo Genes that share domains with NAV1: view

No data available for Gene Families for NAV1 Gene

Function for NAV1 Gene

Molecular function for NAV1 Gene

UniProtKB/Swiss-Prot Function: May be involved in neuronal migration.

Gene Ontology (GO) - Molecular Function for NAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NAV1: view

Phenotypes for NAV1 Gene

GenomeRNAi human phenotypes for NAV1:
genes like me logo Genes that share phenotypes with NAV1: view

miRNA for NAV1 Gene

miRTarBase miRNAs that target NAV1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAV1 Gene

Localization for NAV1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAV1 Gene

Cytoplasm, cytoskeleton. Note=Associates with a subset of microtubule plus ends. Enriched in neuronal growth cones (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAV1 Gene COMPARTMENTS Subcellular localization image for NAV1 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for NAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton --
genes like me logo Genes that share ontologies with NAV1: view

Pathways for NAV1 Gene

SuperPathways for NAV1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAV1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0001764 neuron migration IEA --
genes like me logo Genes that share ontologies with NAV1: view

No data available for Pathways by source for NAV1 Gene

Transcripts for NAV1 Gene

Unigene Clusters for NAV1 Gene

Neuron navigator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAV1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^
SP1: -
SP2:
SP3: -
SP4:
SP5: - -
SP6: - -
SP7:

ExUns: 22 ^ 23
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for NAV1 Gene

GeneLoc Exon Structure for
NAV1
ECgene alternative splicing isoforms for
NAV1

Expression for NAV1 Gene

mRNA expression in normal human tissues for NAV1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAV1 Gene

This gene is overexpressed in Artery - Aorta (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAV1 Gene

SOURCE GeneReport for Unigene cluster for NAV1 Gene Hs.585374

mRNA Expression by UniProt/SwissProt for NAV1 Gene

Q8NEY1-NAV1_HUMAN
Tissue specificity: Broadly expressed at low levels. Expressed at high levels in heart, skeletal muscle and placenta.
genes like me logo Genes that share expressions with NAV1: view

Orthologs for NAV1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAV1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAV1 36
  • 99.64 (n)
  • 100 (a)
NAV1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAV1 36
  • 86.28 (n)
  • 92.41 (a)
NAV1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAV1 36
  • 90.62 (n)
  • 96.1 (a)
NAV1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nav1 36
  • 90.05 (n)
  • 96.37 (a)
Nav1 16
Nav1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAV1 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 97 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC685707 36
  • 90.33 (n)
  • 96.69 (a)
chicken
(Gallus gallus)
Aves NAV1 36
  • 79.61 (n)
  • 87.18 (a)
NAV1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAV1 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nav1 36
  • 65.64 (n)
  • 70.57 (a)
zebrafish
(Danio rerio)
Actinopterygii FP236162.1 37
  • 61 (a)
OneToMany
LOC100005000 36
  • 65.46 (n)
  • 64.75 (a)
NAV1 (1 of 3) 37
  • 67 (a)
OneToMany
NAV1 (2 of 3) 37
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sick 37
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-53 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 32 (a)
OneToMany
Species with no ortholog for NAV1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAV1 Gene

ENSEMBL:
Gene Tree for NAV1 (if available)
TreeFam:
Gene Tree for NAV1 (if available)

Paralogs for NAV1 Gene

Paralogs for NAV1 Gene

Selected SIMAP similar genes for NAV1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NAV1: view

Variants for NAV1 Gene

Sequence variations from dbSNP and Humsavar for NAV1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs125872 -- 201,666,670(+) ATGTT(A/G)CCTAC intron-variant
rs476424 -- 201,606,535(+) TTGCG(C/T)CTCCA intron-variant
rs478472 -- 201,656,695(+) TGCAT(A/G)TAAAC intron-variant
rs481966 -- 201,686,618(+) TCAAG(A/G)TTGCA intron-variant
rs483489 -- 201,602,943(+) AAGTC(A/G)GCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAV1 Gene

Variant ID Type Subtype PubMed ID
nsv818766 CNV Loss 17921354
esv2721495 CNV Deletion 23290073
esv2676669 CNV Deletion 23128226
esv2666987 CNV Deletion 23128226
esv2721506 CNV Deletion 23290073
nsv826187 CNV Loss 20364138
esv1632559 OTHER Inversion 17803354

Relevant External Links for NAV1 Gene

HapMap Linkage Disequilibrium report
NAV1
Human Gene Mutation Database (HGMD)
NAV1

Disorders for NAV1 Gene

(1) University of Copenhagen DISEASES for NAV1 Gene

Relevant External Links for NAV1

Genetic Association Database (GAD)
NAV1
genes like me logo Genes that share disorders with NAV1: view

No data available for UniProtKB/Swiss-Prot for NAV1 Gene

Publications for NAV1 Gene

  1. Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms. (PMID: 12062803) Coy J.F. … Poustka A. (Gene 2002) 2 3 4
  2. Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans. (PMID: 12079279) Maes T. … Buesa C. (Genomics 2002) 2 3 4
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53. (PMID: 15158073) Peeters P.J. … Moechars D.W.E. (Brain Res. Dev. Brain Res. 2004) 3 4

Products for NAV1 Gene

Sources for NAV1 Gene

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