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Aliases for NAT9 Gene

Aliases for NAT9 Gene

  • N-Acetyltransferase 9 (Putative) 2 3 5
  • N-Acetyltransferase 9 (GCN5-Related, Putative) 2
  • Embryo Brain-Specific Protein 4
  • N-Acetyltransferase 9 2
  • EC 2.3.1.- 4
  • EBS 4

External Ids for NAT9 Gene

Previous GeneCards Identifiers for NAT9 Gene

  • GC17M070279
  • GC17M072766
  • GC17M068177

Summaries for NAT9 Gene

GeneCards Summary for NAT9 Gene

NAT9 (N-Acetyltransferase 9 (Putative)) is a Protein Coding gene. Diseases associated with NAT9 include Conjunctival Folliculosis and Epidermolysis Bullosa Simplex, Dowling-Meara Type. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include transferase activity, transferring acyl groups other than amino-acyl groups and N-acetyltransferase activity.

Gene Wiki entry for NAT9 Gene

Additional gene information for NAT9 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT9 Gene

Genomics for NAT9 Gene

Regulatory Elements for NAT9 Gene

Enhancers for NAT9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H074511 2.1 FANTOM5 Ensembl ENCODE dbSUPER 147.4 +262.8 262792 3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 ZNF416 ZNF207 NUP85 NAT9 NT5C GGA3 RN7SL573P HID1-AS1 CD300E CDR2L CD300A ENSG00000266765
GH17H074461 1.9 FANTOM5 Ensembl ENCODE dbSUPER 65.2 +310.6 310626 9 HDGF PKNOX1 FOXA2 ZFP64 SIN3A YBX1 ZNF766 ZNF143 ZNF207 SP5 NAT9 NUP85 NT5C GGA3 CD300A MGC16275 GPR142 CD300LB ARMC7 BTBD17
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 52.3 -315.1 -315101 11 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
GH17H074568 1.8 FANTOM5 Ensembl ENCODE dbSUPER 47.9 +206.8 206839 1 TBP ZNF473 ZSCAN4 SIN3A ZNF195 YBX1 GLI4 EGR1 FOS EGR2 NAT9 NUP85 CD300E NT5C CD300C CD300LB GGA3 ENSG00000266765 LINC02092 ENSG00000265935
GH17H074203 1.4 ENCODE dbSUPER 31.4 +571.2 571245 4 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 RCOR2 NAT9 RN7SL573P NT5C ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935 KCTD2 SUMO2 GC17P074206
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAT9 on UCSC Golden Path with GeneCards custom track

Promoters for NAT9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098261 -5 1201 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Genomic Location for NAT9 Gene

Chromosome:
17
Start:
74,770,547 bp from pter
End:
74,776,395 bp from pter
Size:
5,849 bases
Orientation:
Minus strand

Genomic View for NAT9 Gene

Genes around NAT9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT9 Gene

Proteins for NAT9 Gene

  • Protein details for NAT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE0-NAT9_HUMAN
    Recommended name:
    N-acetyltransferase 9
    Protein Accession:
    Q9BTE0
    Secondary Accessions:
    • B2R7F0
    • Q9BTD0
    • Q9Y3T3

    Protein attributes for NAT9 Gene

    Size:
    207 amino acids
    Molecular mass:
    23361 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAT9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT9 Gene

Post-translational modifications for NAT9 Gene

  • Ubiquitination at Lys118
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NAT9 Gene

Domains & Families for NAT9 Gene

Gene Families for NAT9 Gene

Protein Domains for NAT9 Gene

Suggested Antigen Peptide Sequences for NAT9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTE0

UniProtKB/Swiss-Prot:

NAT9_HUMAN :
  • Belongs to the acetyltransferase family. GNAT subfamily.
Family:
  • Belongs to the acetyltransferase family. GNAT subfamily.
genes like me logo Genes that share domains with NAT9: view

Function for NAT9 Gene

Enzyme Numbers (IUBMB) for NAT9 Gene

Phenotypes From GWAS Catalog for NAT9 Gene

Gene Ontology (GO) - Molecular Function for NAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAT9: view
genes like me logo Genes that share phenotypes with NAT9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAT9

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAT9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT9 Gene

Localization for NAT9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT9 gene
Compartment Confidence
mitochondrion 3
nucleus 3
plasma membrane 2
extracellular 2
cytoskeleton 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NAT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA --
genes like me logo Genes that share ontologies with NAT9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NAT9 Gene

Pathways & Interactions for NAT9 Gene

genes like me logo Genes that share pathways with NAT9: view

Pathways by source for NAT9 Gene

1 BioSystems pathway for NAT9 Gene

Gene Ontology (GO) - Biological Process for NAT9 Gene

None

No data available for SIGNOR curated interactions for NAT9 Gene

Drugs & Compounds for NAT9 Gene

No Compound Related Data Available

Transcripts for NAT9 Gene

Unigene Clusters for NAT9 Gene

N-acetyltransferase 9 (GCN5-related, putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NAT9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NAT9 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b · 10c ^
SP1: - - - - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - - - - - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - - - - - -
SP18: - - - - - - - - - - - - - - - - - -
SP19: - - - - - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - - - -
SP21: - - - - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - - -
SP23: - - - - - - - - -
SP24: - - - - - - - -
SP25: - - - - - - - - - - - - - - - -
SP26: - - - - - - - - - -
SP27: - - - - - - - - - -
SP28: - - - - - -
SP29: - - - - - - - - - - - - - - - -
SP30: - - - - - - - - - - - - - - - -
SP31: - - - - - - - - -
SP32: - - - - - - - - - - - - - - - - - - -
SP33: - - - - - - - - -
SP34: - - - - - - -
SP35: - - - - - - -
SP36: - - -
SP37: - -
SP38:

ExUns: 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h · 13i · 13j · 13k · 13l
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - - -
SP6:
SP7: -
SP8: - - -
SP9: - - - - - - - - - -
SP10: -
SP11:
SP12: - - -
SP13: - - - - - - - - - -
SP14: - - -
SP15: -
SP16: - - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: - - - - - -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:
SP34:
SP35:
SP36:
SP37:
SP38: -

Relevant External Links for NAT9 Gene

GeneLoc Exon Structure for
NAT9
ECgene alternative splicing isoforms for
NAT9

Expression for NAT9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT9 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAT9 Gene



NURSA nuclear receptor signaling pathways regulating expression of NAT9 Gene:

NAT9

SOURCE GeneReport for Unigene cluster for NAT9 Gene:

Hs.144058

Evidence on tissue expression from TISSUES for NAT9 Gene

  • Nervous system(4.9)
  • Muscle(4.5)
  • Lung(4.4)
  • Adrenal gland(4.3)
  • Heart(2.8)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with NAT9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT9 Gene

Orthologs for NAT9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAT9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT9 33 34
  • 99.68 (n)
cow
(Bos Taurus)
Mammalia NAT9 33 34
  • 92.49 (n)
dog
(Canis familiaris)
Mammalia NAT9 33 34
  • 87.42 (n)
rat
(Rattus norvegicus)
Mammalia Nat9 33
  • 86.34 (n)
mouse
(Mus musculus)
Mammalia Nat9 33 16 34
  • 85.2 (n)
oppossum
(Monodelphis domestica)
Mammalia NAT9 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAT9 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAT9 33 34
  • 73.77 (n)
lizard
(Anolis carolinensis)
Reptilia NAT9 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nat9 33
  • 67.91 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100004826 33
  • 63.28 (n)
nat9 34
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11539 33 34
  • 54.32 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007378 33
  • 49.49 (n)
worm
(Caenorhabditis elegans)
Secernentea Y67D2.5 33 34
  • 52.11 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04845 33
  • 55.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC577.03c 33
  • 52.19 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03760 33
  • 47.92 (n)
Species where no ortholog for NAT9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAT9 Gene

ENSEMBL:
Gene Tree for NAT9 (if available)
TreeFam:
Gene Tree for NAT9 (if available)

Paralogs for NAT9 Gene

No data available for Paralogs for NAT9 Gene

Variants for NAT9 Gene

Sequence variations from dbSNP and Humsavar for NAT9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000175461 -- 74,775,486(+) ACCCA(A/G)CCTTT intron-variant, upstream-variant-2KB
rs1000883352 -- 74,777,604(+) CCAAA(C/T)AAAAT intron-variant, upstream-variant-2KB
rs1001063711 -- 74,770,852(+) AGCCA(C/T)AGGGT nc-transcript-variant, utr-variant-3-prime
rs1001480797 -- 74,773,345(+) AATGC(A/T)CTACT intron-variant
rs1001636969 -- 74,775,010(+) GGCAA(A/C)AAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAT9 Gene

Variant ID Type Subtype PubMed ID
nsv952367 CNV deletion 24416366

Variation tolerance for NAT9 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.13; 75.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT9 Gene

Disorders for NAT9 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NAT9 Gene - From: DISEASES

Disorder Aliases PubMed IDs
conjunctival folliculosis
  • acute follicular conjunctivitis
epidermolysis bullosa simplex, dowling-meara type
  • epidermolysis bullosa simplex dowling-meara type
ophthalmia neonatorum
  • gonococcal conjunctivitis
epidermolysis bullosa simplex with muscular dystrophy
  • epidermolysis bullosa simplex and limb-girdle muscular dystrophy
germ cell and embryonal cancer
  • germ cell and embryonal neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search NAT9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAT9

Genetic Association Database (GAD)
NAT9
Human Genome Epidemiology (HuGE) Navigator
NAT9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT9
genes like me logo Genes that share disorders with NAT9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAT9 Gene

Publications for NAT9 Gene

  1. Characterization, expression profile, polymorphism and association of porcine NAT9 gene. (PMID: 21688147) Jiugang Z … Yonggang L (Molecular biology reports 2012) 2 3 60
  2. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik JS … Ridker PM (Circulation. Cardiovascular genetics 2009) 3 45 60
  3. A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. (PMID: 14608357) Helms C … Bowcock AM (Nature genetics 2003) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for NAT9 Gene

Sources for NAT9 Gene

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