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NAT9 Gene

protein-coding   GIFtS: 54

GC17M070279
N-acetyltransferase 9 (GCN5-related, putative)
(Previous name: N-acetyltransferase 9 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZP564C103 1
DKFZp564C103 2
EBS 3
EBSP 2
EC 2.3.1.- 3
Descriptions
Embryo brain-specific protein 3
N-acetyltransferase 9 1, 2
N-acetyltransferase 9 (GCN5-related, putative) 2
embryo brain specific protein 2
External Ids
HGNC: 231331
Entrez Gene: 261512
UniProtKB: Q9BTE03
Ensembl: ENSG000001090657
Search outside databases for aliases for NAT9 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for NAT9
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NAT9 gene  

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.2

NAT9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M070279:     (about GC identifiers)

Start:
70,278,281 bp from pter
End:
70,284,065 bp from pter
Size:
5,785 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000017.9  NT_010641.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAT9_HUMAN, Q9BTE0 (See protein sequence)
Recommended Name: N-acetyltransferase 9  
Size: 207 amino acids; 23361 Da
Secondary accessions: Q9BTD0 Q9Y3T3
Alternative splicing: 2 isoforms:  Q9BTE0-1   Q9BTE0-2   

REFSEQ proteins: NP_056469.2  

ENSEMBL proteins: 
ENSP00000350467 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (NAT9)
Human Recombinant Proteins from Abnova (NAT9)
              OriGene Purified Recombinant Human Protein: NAT9 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0043234 protein complex IDA11256614
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Antibodies for NAT9: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for NAT9
Browse R&D Systems for Antibodies
Antibodies from Abcam (NAT9), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (NAT9)
Novus Biologicals Antibodies for NAT9

Assays for NAT9: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR000182 GCN5-rel_AcTrfase
 IPR016181 Acyl_CoA_acyltransferase


   GeneDecks  NAT9 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BTE0

ProtoNet protein and cluster: Q9BTE0

1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase

UniProtKB/Swiss-Prot: NAT9_HUMAN, Q9BTE0
Similarity: Belongs to the acetyltransferase family. GNAT subfamily
Similarity: Contains 1 N-acetyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NAT9)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015654

              Applied Biosystems Silencer® siRNAs for NAT9

              Sigma-Aldrich siRNA for NAT9  
                     Sigma-Aldrich shRNA for NAT9  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for NAT9
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015654
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015654
                                 untagged cDNA clone in CMV expression vector: NM_015654 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_015654

1 MGI phenotypic allele for Nat9 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008080 N-acetyltransferase activity IEA--
GO:0008415 acyltransferase activity IEA--
GO:0016740 transferase activity IEA--
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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/11 Interacting proteins for NAT9 (ENSP000003504673 Q9BTE02) via UniProtKB, MINT, and/or STRING (see all 11 )
InteractantInteraction Details
GeneCardExternal ID(s)
C14orf1Q9UKR52MINT-65331
CRMP1Q141942MINT-65329
ENO2P091042MINT-63442
KIAA1377Q9P2H02MINT-65330
LUC7L2Q9Y3832MINT-65332
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008152 metabolic process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT9

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (NAT9)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015654

              Sigma-Aldrich siRNA for NAT9  
                     Sigma-Aldrich shRNA for NAT9  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_015654  

REFSEQ mRNAs for NAT9 gene: 

NM_015654.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_015654  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015654
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015654
                                 untagged cDNA clone in CMV expression vector: NM_015654 

Additional cDNA sequence: 

AK123115.1 AK225602.1 AK308569.1 AK312958.1 AL050269.1 AY632082.1 BC004195.2 BC004225.2 
CR590647.1 CR598253.1 CR606498.1 CR614580.1 CR617253.1 CR619487.1 CR622351.1 

20 DOTS entries:

DT.431235  DT.95268536  DT.101984087  DT.97845483  DT.100877625  DT.100877627  DT.92431441  DT.120974535 
DT.100877620  DT.100877613  DT.95204300  DT.100877626  DT.92431440  DT.92431442  DT.100728971  DT.120974543 
DT.120974557  DT.120974560  DT.40130119  DT.95173975 

24/187 AceView cDNA sequences (see all 187 ):

AW268152 BG116888 BQ058149 BQ011880 CR617253 BM972823 BQ057846 AU105749 
BI907688 BE871454 BC004195 BX379416 AL524302 CR619487 CB997391 CB123550 
BM825457 NM_015654 AW008425 CR590647 BM974361 CB123661 BI821280 BE207983 

highest scoring ESTs for NAT9:

AL050269 AK123115 AL534273 AU099475 BC004195 BC004225 BE294493 BF309125 BG761603 BG769633 

Unigene Cluster for NAT9:

N-acetyltransferase 9 (GCN5-related, putative)
Hs.144058  [show with all ESTs]
Unigene Representative Sequence: AK123115


GeneLoc Exon Structure

5/38 Alternative Splicing Database (ASD) splice patterns (SP) for NAT9 (see all 38 )

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9 ^ 10a · 10b · 10c ^
SP1:                          -     -           -     -     -     -     -           -     -     -                 -     -     -     -     -     -     -     -   
SP2:                          -     -           -     -     -     -     -           -     -     -                 -     -     -     -     -     -     -     -   
SP3:                          -     -           -     -     -     -     -           -     -     -                 -     -     -     -     -     -     -     -   
SP4:                          -     -           -     -     -     -     -           -     -     -                 -     -     -     -     -     -     -     -   
SP5:                          -     -           -     -     -     -     -           -     -     -                 -     -     -     -     -     -     -     -   

ExUns: 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h · 13i · 13j · 13k · 13l
SP1:                    -     -     -                                   -                                                                           
SP2:                    -     -     -                                   -                                                                           
SP3:                    -     -     -     -                             -                                                                           
SP4:                    -     -     -                                   -                                                                           
SP5:                    -     -     -     -     -     -     -     -     -     -                                                                     

About this scheme

ECgene alternative splicing isoforms for NAT9

1 Ensembl transcript including schematic representation:
ENST00000357814  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT9 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NAT9

1 / 2 / 3

3 probe-sets matching NAT9 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37877_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AL050269 1.00 1.00 1.00 1

204382_at2, 3 U133-A 1 1.00 1.00 -- -- NM_015654 0.60 1.00 0.82 1

204382_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  NAT9 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCTCAGTATA

SOURCE GeneReport for Unigene cluster: Hs.144058

Expression variation in blood from EXPOLDB for NAT9

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for NAT9 gene from 5/12 species (see all 12 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
NAT91   -- N-acetyltransferase 9 (GCN5-related, putative) 88.04(n)
89.13(a)
483300  XM_540419.2  XP_540419.2 
chimpanzee
(Pan troglodytes)
NAT91   -- N-acetyltransferase 9 (GCN5-related, putative) 99.68(n)
99.03(a)
454866  XM_511664.2  XP_511664.2 
cow
(Bos taurus)
NAT91   -- N-acetyltransferase 9 (GCN5-related, putative) 89.97(n)
88.35(a)
514377  XM_592220.3  XP_592220.2 
rat
(Rattus norvegicus)
Nat91   -- N-acetyltransferase 9 (GCN5-related, putative) 86.34(n)
83.9(a)
303669  XM_221103.4  XP_221103.4 
mouse
(Mus musculus)
Nat91, 5 115
N-acetyltransferase 9 (GCN5-related, putative)5
NAT91
85.2(n)1
82.44(a)1
661761  NM_025400.31  NP_079676.11 
 AI8542915  AK0039485  (see all 13)
About this table        Species with no ortholog for NAT9

ENSEMBL Gene Tree for NAT9
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/33 NCBI SNPs in NAT9 are shown (see all 33 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs8956911,2
A,C,F,H,O70277895(-) TCTGAG/TAGGTG 1 -- ng5112Minor allele frequency- N:0.00EA NA EU WA 1050
rs8808271,2
A,C,F,H,O70279030(+) TCACAT/CGGACC 1 -- ut31 ese318Minor allele frequency- C:0.40EA NA MN EU WA 4218
rs23052131,2
A,C,F,H70281334(-) TGCAGT/CGCAGC 1 R/C mis1 ese312Minor allele frequency- C:0.09EA EU WA NA 1828
rs8956921,2
A,C,F,H70277847(-) TTCCTC/TCTGAG 1 -- ng517Minor allele frequency- T:0.41NA EA EU WA 606
rs127971,2
A,C,F,H70278588(-) GCACCC/TTATGG 1 -- ut31 ese313Minor allele frequency- T:0.36MN NA EU EA WA 1292
rs37442081,2
A,C,F,H70279160(-) GGAGCT/CGGAGG 1 -- ut31 ese35Minor allele frequency- C:0.34EA EU WA 1144
--
rs30880291,2
F,H70278386(+) CTTAGG/ACAAGT 1 -- ut31 ese35Minor allele frequency- A:0.09MN EU EA WA 594
rs129372681,2
F,H70279013(+) GGGCTC/TGTGGT 1 -- ut31 ese33Minor allele frequency- T:0.01EU EA 268
rs8789061,2
A,C,F,O70280929(-) TTGGAA/GTTTTG 1 -- int111Minor allele frequency- G:0.44NA EA 610
rs98928021,2
A,C,F,H70281892(+) CCTTTT/CGAATG 1 -- int116Minor allele frequency- C:0.15NA EU EA WA 2800
About this table

HapMap Linkage Disequilibrium images for NAT9 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

  --

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/16 PubMed articles for NAT9 gene (see all 16 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26151 HGNC: 23133 AceView: EBSP Ensembl:ENSG00000109065 euGenes: HUgn26151
ECgene: NAT9 H-InvDB: NAT9
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for NAT9:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NAT9-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for NAT9 Antibodies for NAT9
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for NAT9 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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(NAT9)
 Antibodies (NAT9)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for NAT9




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for NAT9

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