V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

NAT8L Gene

protein-coding GIFtS: 41

GC04P002031

N-acetyltransferase 8-like (GCN5-related, putative)
(Previous name: N-acetyltransferase 8-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CML3 ^², ³
EC 2.3.1.- ^³
FLJ37478 ^¹, ²
Hcml3 ^¹, ²
MGC117272 ^²
NAT8-LIKE ^²

Descriptions
Camello-like protein 3 ^³
N-acetyltransferase 8-like ^¹
N-acetyltransferase 8-like (GCN5-related, putative) ^²

External Ids
HGNC: 26742¹
Entrez Gene: 339983²
UniProtKB: Q8N9F0³
Ensembl: ENSG00000185818⁷

Search outside databases for aliases for NAT8L gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3

NAT8L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P002031: (about GC identifiers)

Start:	2,031,385 bp from pter
End:	2,037,433 bp from pter
Size:	6,049 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_006081.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NAT8L_HUMAN, Q8N9F0 (See protein sequence)

Recommended Name: N-acetyltransferase 8-like protein

Size: 321 amino acids; 35821 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Sequence caution: Sequence=CAM15218.1; Type=Erroneous gene model prediction;

REFSEQ proteins: NP_848652.1

ENSEMBL proteins:

ENSP00000328464

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FLJ37478)
	Human Recombinant Proteins from Abnova (FLJ37478)

OriGene Purified Recombinant Human Protein: NAT8L

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for NAT8L:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FLJ37478), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FLJ37478)
	Novus Biologicals Antibodies for NAT8L

Assays for NAT8L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8N9F0

ProtoNet protein and cluster: Q8N9F0

UniProtKB/Swiss-Prot: NAT8L_HUMAN, Q8N9F0

Similarity: Belongs to the camello family

Similarity: Contains 1 N-acetyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT8L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178557

Applied Biosystems Silencer® siRNAs for NAT8L

Sigma-Aldrich siRNA for NAT8L

Sigma-Aldrich shRNA for NAT8L

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAT8L
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_178557
Myc/DDK tagged cDNA clone in CMV expression vector: NM_178557
untagged cDNA clone in CMV expression vector: NM_178557

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_178557

1 MGI phenotypic allele

for Nat8l (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008080	N-acetyltransferase activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT8L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT8L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178557

Sigma-Aldrich siRNA for NAT8L

Sigma-Aldrich shRNA for NAT8L

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_178557

REFSEQ mRNAs for NAT8L gene:

NM_178557.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_178557

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_178557
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_178557
                                 untagged cDNA clone in CMV expression vector: NM_178557

Additional cDNA sequence:

AK094797.1 BC093906.1 BC093908.1 BC103748.1

3 DOTS entries:

DT.425156 DT.92037245 DT.100657725

24/90 AceView cDNA sequences (see all 90 ):

BE222771 AI871391 BQ926344 AI565540 BM692785 BF363480 BG222544 BQ950958

AL137326 AK094797 BI252293 BG760474 BQ934976 BE739858 BE261975 BQ423995

CD513265 BE781941 BV179538 BM799472 CD106734 BQ882031 AA527169 AI890566

highest scoring ESTs for NAT8L:

AA527169 AA984774 AI758794 AK094797 AW614326 BF125364 BF312393 BF356337 BF684989 BG282376

Unigene Cluster for NAT8L:

N-acetyltransferase 8-like (GCN5-related, putative)

Hs.318529 [show with all ESTs]

Unigene Representative Sequence: NM_178557

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000331662

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT8L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAT8L

¹ / ² / ³

2 probe-sets matching NAT8L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
235316_at²^{, 3}	U133-B	1	0.82	1.00	--	--	BG258131	0.40	1.00	0.76	1
235316_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAGGGATGCT

SOURCE GeneReport for Unigene cluster: Hs.318529

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAT8L gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAT8L¹	--	N-acetyltransferase 8-like (GCN5-related, putative)	94.03(n) 97.76(a)	612955 XM_848174.1 XP_853267.1
rat (Rattus norvegicus)	Nat8l¹	--	N-acetyltransferase 8-like	89.3(n) 97.76(a)	289727 XM_223538.4 XP_223538.3
mouse (Mus musculus)	Nat8l^{1, 5}	5⁵	N-acetyltransferase 8-like^{1, 5}	90.3(n)¹ 97.76(a)¹	269642¹ NM_001001985.3¹ NP_001001985.3¹ AI644670⁵ AI849874⁵ (see all 12)
chicken (Gallus gallus)	NAT8L¹	--	N-acetyltransferase 8-like	80.1(n) 84.33(a)	422893 XM_420835.2 XP_420835.2
zebrafish (Danio rerio)	sbcb562²	--	sbcb562	78.21(n)	368296 BI428117.1

About this table Species with no ortholog for NAT8L

ENSEMBL Gene Tree for NAT8L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NAT8L gene

ENSG00000204872² NAT8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in NAT8L are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 46)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11248082^1,2	A,C	2035744(+)	`GCTCAA/CTTGGC`	1	--	ut3¹		0	--	--	--	--
--	rs3135158^1,2	C	2036070(-)	`CAGCTC/GGGGCC`	1	--	ut3¹ ese³		0	--	--	--	--
	rs382701^1,2	A,C,F,H	2035054(-)	`GAGCTG/CCTTAA`	1	--	int¹		7		MN EU EA WA NA	762
	rs454226^1,2	A,C,F	2035171(-)	`AAGCCC/AGGGCA`	1	--	int¹		1		MN	184
--	rs3135160^1,2	C	2032021(-)	`CACACC/TGCTTC`	1	--	int¹		0	--	--	--	--
	rs558749^1,2	--	2037321(+)	`CCCCGC/TTGGGG`	1	--	ut3¹		0	--	--	--	--
	rs460589^1,2	--	2035471(-)	`CCACCG/CCGGAG`	1	G/A	mis¹ ese³		1		MN	184
	rs420351^1,2	--	2036631(-)	`CCCAAA/GAATAA`	1	--	ut3¹		0	--	--	--	--
	rs450274^1,2	--	2036797(-)	`CCCACA/CCTGCA`	1	--	ut3¹		0	--	--	--	--
--	rs61504086^1,2	--	2036742(+)	`GAAACC/GCTGAT`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NAT8L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 610647

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for NAT8L gene:

Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. (PubMed id 11397015)^{2, 3, 4} Popsueva A.E....Belyavsky A.V. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)⁴ Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 339983	HGNC: 26742	AceView: FLJ37478	Ensembl:ENSG00000185818	euGenes: HUgn339983
ECgene: NAT8L	H-InvDB: NAT8L

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NAT8L
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAT8L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAT8L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAT8L		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAT8L		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FLJ37478)
	Antibodies (FLJ37478)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FLJ37478)
	Antibodies (FLJ37478)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NAT8L

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NAT8L

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NAT8L Gene at Home site.
Version 2.41.1
server5.xennexinc.com

NAT8L Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for NAT8L

Summaries
for NAT8L

Genomic Location
for NAT8L

Proteins
for NAT8L

Protein Domains/
Families
for NAT8L

Gene Function
for NAT8L

Pathways & Interactions
for NAT8L

Drugs & Compounds
for NAT8L

Transcripts
for NAT8L

Expression
for NAT8L

Orthologs
for NAT8L

Paralogs
for NAT8L

SNPs/Variants
for NAT8L

Disorders & Mutations
for NAT8L

Medical News
for NAT8L

Publications
for NAT8L

Search for NAT8L

Genome Databases showing NAT8L

Other Databases showing NAT8L

Specialized Databases showing NAT8L

Licensable Technologies
for NAT8L

Services
for NAT8L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAT8L Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor NAT8L

Summariesfor NAT8L

Genomic Locationfor NAT8L

Proteinsfor NAT8L

Protein Domains/Familiesfor NAT8L

Gene Functionfor NAT8L

Pathways & Interactionsfor NAT8L

Drugs & Compoundsfor NAT8L

Transcriptsfor NAT8L

Expression for NAT8L

Orthologsfor NAT8L

Paralogsfor NAT8L

SNPs/Variantsfor NAT8L

Disorders & Mutationsfor NAT8L

Medical Newsfor NAT8L

Publicationsfor NAT8L

Search for NAT8L

Genome Databases showing NAT8L

Other Databases showing NAT8L

Specialized Databases showing NAT8L

Licensable Technologiesfor NAT8L

Servicesfor NAT8L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAT8L

Summaries
for NAT8L

Genomic Location
for NAT8L

Proteins
for NAT8L

Protein Domains/
Families
for NAT8L

Gene Function
for NAT8L

Pathways & Interactions
for NAT8L

Drugs & Compounds
for NAT8L

Transcripts
for NAT8L

Expression
for NAT8L

Orthologs
for NAT8L

Paralogs
for NAT8L

SNPs/Variants
for NAT8L

Disorders & Mutations
for NAT8L

Medical News
for NAT8L

Publications
for NAT8L

Licensable Technologies
for NAT8L

Services
for NAT8L