Aliases for NAT8B Gene
External Ids for NAT8B Gene
Previous GeneCards Identifiers for NAT8B Gene
The protein encoded by this gene is highly similar to the N-acetyltransferase 8 (NAT8) gene product, which is a kidney and liver protein with homology to bacterial acetyltransferases involved in drug resistance. This gene is localized on chromosome 2 in the vicinity of the NAT8 gene and may represent a pseudogene of NAT8. This gene contains two polymorphic nonsense mutations that disrupt the active site of the protein. The full-length product of this gene contains a complete acetyltransferase domain and is identical in length to NAT8. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAT8B Gene
NAT8B (N-Acetyltransferase 8B (Putative, Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Metabolism of proteins. GO annotations related to this gene include N-acetyltransferase activity and lysine N-acetyltransferase activity, acting on acetyl phosphate as donor. An important paralog of this gene is NAT8.
UniProtKB/Swiss-Prot for NAT8B Gene
May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241).