NAT8 Gene
protein-coding GIFtS: 54
GCID: GC02M073779
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N-acetyltransferase 8 (GCN5-related, putative)(Previous name: N-acetyltransferase 8 )
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Aliases
for NAT8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Acetyltransferase 8 (GCN5-Related, Putative)1 2 | | TSC5102 5 | | GLA1 2 3 | | N-Acetyltransferase 81 | | TSC5011 2 3 | | Kidney- And Liver-Specific Gene Product2 | | ATase21 2 | | N-Acetyltransferase 8 (Camello Like)2 | | Hcml11 2 | | Probable N-Acetyltransferase 82 | | Camello-Like Protein 12 3 | | EC 2.3.1.-3 | | CML12 3 | | EC 2.3.18 |
Export aliases for NAT8 gene to outside databasesPrevious GC identifers: GC02M073877 GC02M074078 GC02M073842 |
Summaries
for NAT8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAT8:
This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed inkidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar proteinin Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highlysimilar paralog is found in a cluster with this gene. (provided by RefSeq, Sep 2008)
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Function: Plays a role in regulation of gastrulation
Gene Wiki entry for NAT8
|
Genomic Views
for NAT8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAT8 gene promoter:
p53 NRSF form 1 Cart-1 Nkx2-5 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAT8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.2 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.2NAT8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M073779: view genomic region
(about GC identifiers)
Start:
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73,867,850 bp from pter |
End:
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73,869,537 bp from pter |
Size:
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1,688 bases |
Orientation:
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minus strand |
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Proteins
for NAT8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5 (See
protein sequence)Recommended Name: Probable N-acetyltransferase 8 Size: 227 amino acids; 25619 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O75839 Q6LEU4 Q96QI8 Q9UQ17Explore the universe of human proteins at neXtProt for NAT8: NX_Q9UHE5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UHE5
2 DME Specific Peptides for NAT8 (Q9UHE5)
NAT8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003951.3
ENSEMBL proteins: ENSP00000272425
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
NAT8 for ontologies About GeneDecksing
NAT8 Antibody Products:
Assay Products for NAT8: |
Protein
Domains /
Families
for NAT8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAT8 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UHE5ProtoNet protein and cluster: Q9UHE5 1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Similarity: Belongs to the camello familySimilarity: Contains 1 N-acetyltransferase domain |
Function
for NAT8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Function: Plays a role in regulation of gastrulationEnzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NAT8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008080 | N-acetyltransferase activity |
NAS | 11397015 |
NAT8 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NAT8:
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Pathways & Interactions
for NAT8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Biological oxidations | |
1  BioSystems Pathway for NAT8
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAT8
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for NAT8 (Q9UHE53 ENSP000002724254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
NAT8 for ontologies About GeneDecksing
|
Drugs & Compounds
for NAT8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAT8
Search CenterWatch for drugs/clinical trials and news about NAT8
|
Transcripts
for NAT8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAT8 gene: NM_003960.3 Unigene Cluster for NAT8: N-acetyltransferase 8 (GCN5-related, putative) Hs.14637 [show with all ESTs]Unigene Representative Sequence: BQ6442051 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000272425(uc002sji.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAT8 (NM_003960) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAT8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT8 |
Additional cDNA sequence: AB013094.1 AB019551.1 AF187813.1 BC012626.1 CR407610.1 4 DOTS entries: DT.100812576 DT.100812571 DT.95372741 DT.75163459 24/65 AceView cDNA sequences (see all 65): AA581767 BI761242 AI283636 AA985528 AI431825 N71326 N71377 AI174771 CB161536 BM924554 AA866208 AA746068 CR407610 BV183414 BG400318 N58170 BI759763 AL698327 AL698313 BF104869 NM_003960 BG427792 BI762640 BI761696
GeneLoc Exon Structure
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Expression
for NAT8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAT8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTTCAAGA
About this image
See NAT8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAT8
SOURCE GeneReport for Unigene cluster: Hs.14637
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Tissue specificity: Expression is restricted to liver and kidney
SABiosciences Custom PCR Arrays for NAT8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAT8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT8 |
Orthologs
for NAT8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NAT8 gene from 3/9 species (see all 9) About this table
ENSEMBL Gene Tree for NAT8 (if available)
TreeFam Gene Tree for NAT8 (if available) |
Paralogs
for NAT8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAT8 gene
- NAT8L2
2 SIMAP similar genes for NAT8 using alignment to 1 protein entry: NAT8_HUMAN:NAT8B NAT8L
NAT8 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NAT8
PGOHUM00000240094
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Genomic Variants
for NAT8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAT8 (73867850 - 73869537 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NAT8
4 CNVs: 9415 3365 50553 97885 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT8 |
|
Disorders
/ Diseases
for NAT8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAT8 for disorders About GeneDecksing
OMIM gene information: 606716
OMIM disorders: --
3  diseases for NAT8: About MalaCardsliver cirrhosis kidney disease neuronitis
Human Genome Epidemiology (HuGE) Navigator: NAT8 (2 documents)
Export disorders for NAT8 gene to outside databases
|
Publications
for NAT8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAT8 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NAT8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. (PubMed id 11397015)1, 2, 3 Popsueva A.E....Belyavsky A.V. (2001)
- Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases. (PubMed id 9852678)1, 2, 3 Ozaki K.... Takahashi E. (1998)
- Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. (PubMed id 19011241)1, 3 Ko M.H. and Puglielli L. (2009)
- N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study. (PubMed id 18402670)1, 9 Juhanson P....Laan M. (2008)
- Molecular identification of NAT8 as the enzyme that a cetylates cysteine S-conjugates to mercapturic acids. (PubMed id 20392701)1, 9 Veiga-da-Cunha M....Van Schaftingen E. (2010)
- Biochemical inhibition of the acetyltransferases ATase 1 and ATase2 reduces b-secretase (BACE1) levels and Ab generation. (PubMed id 22267734)1 Ding Y....Puglielli L. (2012)
- A genome-wide metabolic QTL analysis in Europeans impl icates two loci shaped by recent positive selection. (PubMed id 21931564)1 Nicholson G....Holmes C.C. (2011)
- Human metabolic individuality in biomedical and pharma ceutical research. (PubMed id 21886157)1 Suhre K....Gieger C. (2011)
- Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabo lism in the CNS. (PubMed id 20385109)1 Ariyannur P.S....Namboodiri A.M. (2010)
- Genetic loci influencing kidney function and chronic kidney disease. (PubMed id 20383145)1 Chambers J.C....Kooner J.S. (2010)
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External Searches for NAT8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NAT8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAT8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAT8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAT8 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAT8 gene:
Search GeneIP for patents involving NAT8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAT8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NAT8 | | OriGene shRNA RFP for NAT8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT8 | | | OriGene Protein Over-expression Lysate for NAT8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAT8 | | OriGene 3'-UTR Clone for NAT8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NAT8 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAT8 | | OriGene Custom Protein Services for NAT8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAT8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT8 |
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 | | | NAT8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT8 |
|  |  |  | | | | ThermoFisher Antibodies for NAT8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT8 |
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