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Aliases & Descriptions for NAT8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CML1 2, 3 | | EC 2.3.1.- 3 | | GLA 1, 2, 3 | | Hcml1 1, 2 | | TSC501 1, 2, 3 | | TSC510 2, 5 |
| | | Descriptions |
|---|
| Camello-like protein 1 2, 3 | | N-acetyltransferase 8 1, 2 | | N-acetyltransferase 8 (GCN5-related, putative) 2 | | N-acetyltransferase 8 (camello like) 2 | | kidney- and liver-specific gene product 2 |
|
| | Search outside databases for aliases for NAT8 genePrevious GC identifers: GC02M073877 GC02M074078 GC02M073842 |
Summaries for NAT8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAT8: This gene, isolated using the differential display method to detect tissue-specific genes, is specifically expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases. A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the secretory pathway. A highly similar paralog is found in a cluster with this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Function: Plays a role in regulation of gastrulation |
Genomic Location for NAT8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAT8 gene 
Entrez Gene cytogenetic band: 2p13.1-p12 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p13.2NAT8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M073779:
(about GC identifiers)
Start:
|
73,721,358 bp from pter |
End:
|
73,723,045 bp from pter |
Size:
|
1,688 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022184.14
| Proteins for NAT8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5 (See
protein sequence)Recommended Name: Probable N-acetyltransferase 8 Size: 227 amino acids; 25619 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: O75839 Q6LEU4 Q96QI8 Q9UQ17REFSEQ proteins: NP_003951.3
ENSEMBL proteins: ENSP00000272425
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NAT8 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NAT8: Assays for NAT8: | Protein
Domains/ Families for NAT8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UHE5
ProtoNet protein and cluster: Q9UHE5 1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Similarity: Belongs to the camello familySimilarity: Contains 1 N-acetyltransferase domain | Gene Function for NAT8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003960
Applied Biosystems Silencer® siRNAs for NAT8
Sigma-Aldrich siRNA and siRNA Panels for NAT8  Sigma-Aldrich shRNA for NAT8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003960                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003960                                  untagged cDNA clone in CMV expression vector: NM_003960 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003960
UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Function: Plays a role in regulation of gastrulationEnzyme Number (IUBMB): EC 2.3.1.- 3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for NAT8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for NAT8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAT8
|
Transcripts for NAT8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003960
Sigma-Aldrich siRNA and siRNA Panels for NAT8  Sigma-Aldrich shRNA for NAT8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003960 REFSEQ mRNAs for NAT8 gene: NM_003960.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003960               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003960                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003960                                  untagged cDNA clone in CMV expression vector: NM_003960  Additional cDNA sequence: AB013094.1 AB019551.1 AF187813.1 BC012626.1 CR407610.1 4 DOTS entries: DT.100812576 DT.100812571 DT.95372741 DT.75163459 24/65 AceView cDNA sequences (see all 65
):AA985528 CB161536 BI761242 AI431825 BM924554 AA581767 AI283636 N71377 AI174771 N71326 BG401637 BI759077 BI763593 BV199736 BG426653 BG563833 AL698327 BG427673 AB019551 N75734 NM_003960 N58170 BI762640 BI759313
highest scoring ESTs for NAT8:AB013094 AB019551 AF187813 AI174771 AV650091 BC012626 BF104866 BF104869 BG400118 BG400318 Unigene Cluster for NAT8: N-acetyltransferase 8 (GCN5-related, putative) Hs.14637 [show with all ESTs]Unigene Representative Sequence: BQ644205
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000272425
|
Expression for NAT8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAT8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAT8
1 / 2 / 3 5 probe-sets matching NAT8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGCTTCAAGA
SOURCE GeneReport for Unigene cluster: Hs.14637
Expression variation in blood from EXPOLDB for NAT8 UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5Tissue specificity: Expression is restricted to liver and kidney |
Orthologs for NAT8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAT8 gene from 3 species
About this table Species with no ortholog for NAT8
ENSEMBL Gene Tree for NAT8 | Paralogs for NAT8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAT8 gene
- ENSG000002048722 NAT8L2
|
SNPs/Variants for NAT8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAT8 (up to first 250kb)
|
Disorders & Mutations for NAT8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 606716
1 PharmGKB disease relationship for NAT8 geneAbout this table
Human Genome Epidemiology Navigator: NAT8 (1 document)
|
Medical News for NAT8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAT8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for NAT8 gene (see all 14
):- Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. (PubMed id 11397015)2, 3, 4 Popsueva A.E....Belyavsky A.V. (2001)
- Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases. (PubMed id 9852678)2, 3, 4 Ozaki K....Takahashi E. (1998)
- N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study. (PubMed id 18402670)1, 3 Juhanson P....Laan M. (2008)
- Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. (PubMed id 19011241)3 Ko M.H. and Puglielli L. (2009)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)3 Barrios-Rodiles M....Wrana J.L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12086872)7 Yeoh E.J....Downing J.R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- [Agenesis and aplasia of the kidney in children in the x-ray diagnostic picture] (PubMed id 1139715)3 Vereb J....Tischler V. (1975)
- Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. (PubMed id 18450759)1 Coutu D.L....Galipeau J. (2008)
|
Search for NAT8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAT8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAT8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAT8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAT8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAT8:

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GeneCards Homepage - Last full update: 1 Jul 2009
Incremental update: 13 Oct 2009
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