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NAT8 Gene

protein-coding   GIFtS: 57
GCID: GC02M073779

N-Acetyltransferase 8 (GCN5-Related, Putative)

(Previous name: N-acetyltransferase 8)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetyltransferase 8 (GCN5-Related, Putative)1 2     ATase22
Camello-Like Protein 12 3     Hcml12
CML12 3     Kidney- And Liver-Specific Gene Product2
GLA2 3     N-Acetyltransferase 8 (Camello Like)2
TSC5012 3     Probable N-Acetyltransferase 82
TSC5102 5     EC 2.3.1.-3
N-Acetyltransferase 81     EC 2.3.18

External Ids:    HGNC: 180691   Entrez Gene: 90272   Ensembl: ENSG000001440357   OMIM: 6067165   UniProtKB: Q9UHE53   

Export aliases for NAT8 gene to outside databases

Previous GC identifers: GC02M073877 GC02M074078 GC02M073842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAT8 Gene:
This gene, isolated using the differential display method to detect tissue-specific genes, is specifically
expressed in kidney and liver. The encoded protein shows amino acid sequence similarity to N-acetyltransferases.
A similar protein in Xenopus affects cell adhesion and gastrulation movements, and may be localized in the
secretory pathway. A highly similar paralog is found in a cluster with this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for NAT8 Gene:
NAT8 (N-acetyltransferase 8 (GCN5-related, putative)) is a protein-coding gene. Diseases associated with NAT8 include liver cirrhosis, and kidney disease. GO annotations related to this gene include N-acetyltransferase activity. An important paralog of this gene is NAT8L.

UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5
Function: Plays a role in regulation of gastrulation

Gene Wiki entry for NAT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAT8 gene promoter:
         p53   NRSF form 1   Cart-1   Nkx2-5   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAT8 promoter sequence
   Search Chromatin IP Primers for NAT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p13.2   Ensembl cytogenetic band:  2p13.1   HGNC cytogenetic band: 2p13.2

NAT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT8 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M073779:  view genomic region     (about GC identifiers)

Start:
73,867,850 bp from pter      End:
73,869,537 bp from pter
Size:
1,688 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5 (See protein sequence)
Recommended Name: Probable N-acetyltransferase 8  
Size: 227 amino acids; 25619 Da
Secondary accessions: O75839 Q6LEU4 Q96QI8 Q9UQ17

Explore the universe of human proteins at neXtProt for NAT8: NX_Q9UHE5

Explore proteomics data for NAT8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for NAT8 (Q9UHE5)
     DITKSYL  VLQFARDQGY 


    See NAT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003951.3  
    ENSEMBL proteins: 
     ENSP00000272425  

    NAT8 Human Recombinant Protein Products:

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    Novus Biologicals NAT8 Protein
    Novus Biologicals NAT8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NAT8

    NAT8 Antibody Products:

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    Novus Biologicals NAT8 Antibodies
    Abcam antibodies for NAT8
    Cloud-Clone Corp. Antibodies for NAT8
    ThermoFisher Antibodies for NAT8
    LSBio Antibodies in human, mouse, rat for NAT8

    NAT8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAT8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAT8
    Cloud-Clone Corp. CLIAs for NAT8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q9UHE5

    ProtoNet protein and cluster: Q9UHE5

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5
    Similarity: Belongs to the camello family
    Similarity: Contains 1 N-acetyltransferase domain


    NAT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAT8_HUMAN, Q9UHE5
    Function: Plays a role in regulation of gastrulation

         Enzyme Numbers (IUBMB): EC 2.3.12 EC 2.3.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008080N-acetyltransferase activity NAS11397015
    GO:0016747transferase activity, transferring acyl groups other than amino-acyl groups ----
         
    NAT8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAT8:
     Decreased cilium length after   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAT8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAT8

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAT8:
    hsa-mir-769-5p (MIRT039206), hsa-mir-615-3p (MIRT039851)

    Block miRNA regulation of human, mouse, rat NAT8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NAT8:
    hsa-miR-1257
    SwitchGear 3'UTR luciferase reporter plasmidNAT8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAT8
    Predesigned siRNA for gene silencing in human, mouse, rat NAT8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAT8

    Clone
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    OriGene clones in human, mouse for NAT8 (see all 5)
    OriGene ORF clones in mouse, rat for NAT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAT8 (NM_003960)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT8

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NAT8
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAT8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAT8_HUMAN, Q9UHE5: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane NAS11397015

    NAT8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAT8 About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.42


    1 BioSystems Pathway for NAT8
        metapathway biotransformation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAT8
    Interactions:

        Search GeneGlobe Interaction Network for NAT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for NAT8 (Q9UHE53 ENSP000002724254) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFBR1P368973, ENSP000003641334I2D: score=2 STRING: ENSP00000364133
    SMAD4Q134853, ENSP000003415514I2D: score=2 STRING: ENSP00000341551
    NAA35ENSP000003549724STRING: ENSP00000354972
    TOP1ENSP000003545224STRING: ENSP00000354522
    HDAC1ENSP000003626494STRING: ENSP00000362649
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001702gastrulation with mouth forming second IMP11397015
    GO:0008152metabolic process TAS9852678
    GO:0042493response to drug TAS9852678

    NAT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAT8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAT8 gene: 
    NM_003960.3  

    Unigene Cluster for NAT8:

    N-acetyltransferase 8 (GCN5-related, putative)
    Hs.14637  [show with all ESTs]
    Unigene Representative Sequence: BQ644205
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000272425(uc002sji.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat NAT8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NAT8:
    hsa-miR-1257
    SwitchGear 3'UTR luciferase reporter plasmidNAT8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAT8
    Predesigned siRNA for gene silencing in human, mouse, rat NAT8
    Clone
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    OriGene clones in human, mouse for NAT8 (see all 5)
    OriGene ORF clones in mouse, rat for NAT8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAT8 (NM_003960)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAT8
    OriGene qSTAR qPCR primer pairs in human, mouse for NAT8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT8
      QuantiTect SYBR Green Assays in human, mouse, rat NAT8
      QuantiFast Probe-based Assays in human, mouse, rat NAT8

    Additional mRNA sequence: 

    AB013094.1 AB019551.1 AF187813.1 BC012626.1 CR407610.1 

    4 DOTS entries:

    DT.100812576  DT.100812571  DT.95372741  DT.75163459 

    Selected AceView cDNA sequences (see all 65):

    AI174771 AI283636 AA581767 BI761242 AI431825 N71377 AA985528 BM924554 
    CB161536 N71326 BI762640 BG401637 BV183414 BF104869 BI761696 BG400118 
    BG400318 BI759077 BG427673 BI759313 N58170 AL698327 BG427792 AI311736 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTCAAGA
    NAT8 Expression
    About this image

    NAT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14637

    UniProtKB/Swiss-Prot: NAT8_HUMAN, Q9UHE5
    Tissue specificity: Expression is restricted to liver and kidney

        Custom PCR Arrays for NAT8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NAT8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nat81 , 5 N-acetyltransferase 8 (GCN5-related, putative)1, 5 71.6(n)1
    61.88(a)1
      6 (37.49 cM)5
    683961  NM_023455.31  NP_075944.11 
     858303885 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    35(a)
    33(a)
    1 ↔ many
    1 ↔ many
    GL343698.1(47647-48306)
    GL343698.1(24670-37281)
    zebrafish
    (Danio rerio)
    Actinopterygii CR559945.36
    Uncharacterized protein
    34(a)
    1 ↔ 1
    13(11393399-11394064) ENSDARG00000078991


    ENSEMBL Gene Tree for NAT8 (if available)
    TreeFam Gene Tree for NAT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAT8 gene
    NAT8L2  
    2 SIMAP similar genes for NAT8 using alignment to 1 protein entry:     NAT8_HUMAN:
    NAT8B    NAT8L

    NAT8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAT8
    PGOHUM00000240094


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAT8 (see all 141)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs45382321,2
    C,A--73867354(+) tcaggG/Tattct 1 -- ds50014Minor allele frequency- T:0.00NA WA CSA 6
    rs1471773361,2
    C--73867358(+) GTATTC/TTGTTA 1 -- ds50010--------
    rs1122031381,2
    F--73867421(+) ACACTC/TCCCTC 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs43286561,2
    C,F,A,H--73867460(+) CCCTGT/GAGTTA 1 -- ds50016Minor allele frequency- G:0.23NS EA NA 282
    rs44147031,2
    C,A--73867461(+) CCTGGG/AGTTAG 1 -- ds50013Minor allele frequency- A:0.17NA 6
    rs18796651,2
    C,F,A--73867469(-) AATCCA/CCTCTA 1 -- ds50017Minor allele frequency- C:0.07MN NA CSA 195
    rs18796641,2
    C,F,A--73867476(-) cacaaC/Tcaatc 1 -- ds50018Minor allele frequency- T:0.05MN NA CSA 196
    rs18796631,2
    C,F,A--73867494(-) AAGAAT/CTGGGG 1 -- ds50018Minor allele frequency- C:0.05MN NA WA CSA 197
    rs1855154991,2
    --73867596(+) GCAACA/GCATGC 1 -- ds50010--------
    rs1892771291,2
    --73867667(+) TGAAAC/TCATGC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NAT8 (73867850 - 73869537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NAT8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720207CNV Deletion23290073
    dgv707e199CNV Deletion23128226
    esv2497164CNV Deletion19546169
    nsv874276CNV Loss21882294
    dgv4163n71CNV Loss21882294
    nsv515605CNV Loss19592680
    nsv829460CNV Gain20364138
    nsv818044CNV Gain17921354
    essv105CNV CNV17122850
    dgv1197e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NAT8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAT8
    DNA2.0 Custom Variant and Variant Library Synthesis for NAT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606716    OMIM disorders: --

    3 diseases for NAT8:    
    About MalaCards
    liver cirrhosis    kidney disease    neuronitis


    NAT8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NAT8
    Human Genome Epidemiology (HuGE) Navigator: NAT8 (2 documents)

    Export disorders for NAT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAT8 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NAT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpression of camello, a member of a novel protein family, reduces blastomere adhesion and inhibits gastrulation in Xenopus laevis. (PubMed id 11397015)1, 2, 3 Popsueva A.E....Belyavsky A.V. (Dev. Biol. 2001)
    2. Isolation and mapping of a novel human kidney- and liver-specific gene homologous to the bacterial acetyltransferases. (PubMed id 9852678)1, 2, 3 Ozaki K.... Takahashi E. (J. Hum. Genet. 1998)
    3. N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study. (PubMed id 18402670)1, 4, 9 Juhanson P....Laan M. (BMC Med. Genet. 2008)
    4. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    5. Genetic loci influencing kidney function and chronic kidney disease. (PubMed id 20383145)1, 4 Chambers J.C....Kooner J.S. (Nat. Genet. 2010)
    6. Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels. (PubMed id 19011241)1, 3 Ko M.H. and Puglielli L. (J. Biol. Chem. 2009)
    7. Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids. (PubMed id 20392701)1, 9 Veiga-da-Cunha M....Van Schaftingen E. (J. Biol. Chem. 2010)
    8. Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate. (PubMed id 23535967)1 Tin A....Kao W.H. (J. Hum. Genet. 2013)
    9. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 23934736)1 Yu B....Boerwinkle E. (Genet. Epidemiol. 2013)
    10. Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces I^-secretase (BACE1) levels and AI^ generation. (PubMed id 22267734)1 Ding Y....Puglielli L. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9027 HGNC: 18069 AceView: NAT8 Ensembl:ENSG00000144035 euGenes: HUgn9027
    ECgene: NAT8 H-InvDB: NAT8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAT8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAT8 gene:
    Search GeneIP for patents involving NAT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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