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Aliases for NAT6 Gene

Aliases for NAT6 Gene

  • N-Acetyltransferase 6 2 3 5
  • N-Acetyltransferase 6 (GCN5-Related) 2 3
  • Protein Fusion-2 3 4
  • FUS2 3 4
  • Protein Fus-2 4
  • EC 2.3.1.- 4
  • FUS-2 3

External Ids for NAT6 Gene

Previous GeneCards Identifiers for NAT6 Gene

  • GC03M050293
  • GC03M050300
  • GC03M050308
  • GC03M050333

Summaries for NAT6 Gene

Entrez Gene Summary for NAT6 Gene

  • This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAT6 Gene

NAT6 (N-Acetyltransferase 6) is a Protein Coding gene. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT6 Gene

  • Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT6 Gene

Genomics for NAT6 Gene

Regulatory Elements for NAT6 Gene

Enhancers for NAT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G050234 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13 +54.2 54166 21.3 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D HYAL3 GNAI2 HYAL1 CYB561D2 SEMA3B SEMA3B-AS1 LSMEM2 NAT6 IFRD2 SEMA3F-AS1
GH03G050598 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 10.2 -307.1 -307066 15.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 TMEM115 HEMK1 RAD54L2 C3orf18 SEMA3F-AS1 DOCK3 MANF GMPPB NAT6 TRAIP
GH03G050566 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -272.5 -272483 10.0 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 CISH RAD54L2 SEMA3F-AS1 MAPKAPK3 TMEM115 HEMK1 DOCK3 NAT6 TRAIP RASSF1
GH03G049338 1.9 FANTOM5 ENCODE dbSUPER 11 +953.4 953372 14.7 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC AMT QRICH1 IMPDH2 DALRD3 RHOA WDR6 NICN1 USP4 ENSG00000230454 RHOA-IT1
GH03G050327 1.3 ENCODE dbSUPER 13.4 -28.6 -28616 2.0 HDGF PKNOX1 MLX AGO1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS HYAL3 NAT6 HYAL1 MST1 TUSC2 HYAL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAT6 on UCSC Golden Path with GeneCards custom track

Promoters for NAT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152338 21 1201 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1

Transcription factor binding sites by QIAGEN in the NAT6 gene promoter:

Genomic Location for NAT6 Gene

Chromosome:
3
Start:
50,296,402 bp from pter
End:
50,299,421 bp from pter
Size:
3,020 bases
Orientation:
Minus strand

Genomic View for NAT6 Gene

Genes around NAT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT6 Gene

Proteins for NAT6 Gene

  • Protein details for NAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93015-NAT6_HUMAN
    Recommended name:
    N-acetyltransferase 6
    Protein Accession:
    Q93015
    Secondary Accessions:
    • Q93014

    Protein attributes for NAT6 Gene

    Size:
    286 amino acids
    Molecular mass:
    31445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT6 Gene

Post-translational modifications for NAT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAT6 Gene

Domains & Families for NAT6 Gene

Gene Families for NAT6 Gene

Protein Domains for NAT6 Gene

Suggested Antigen Peptide Sequences for NAT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93015

UniProtKB/Swiss-Prot:

NAT6_HUMAN :
  • Belongs to the acetyltransferase family.
Family:
  • Belongs to the acetyltransferase family.
genes like me logo Genes that share domains with NAT6: view

Function for NAT6 Gene

Molecular function for NAT6 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

Enzyme Numbers (IUBMB) for NAT6 Gene

Gene Ontology (GO) - Molecular Function for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAT6: view
genes like me logo Genes that share phenotypes with NAT6: view

Animal Model Products

miRNA for NAT6 Gene

miRTarBase miRNAs that target NAT6

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT6 Gene

Localization for NAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT6 Gene

Cytoplasm.

Gene Ontology (GO) - Cellular Components for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NAT6: view

No data available for Subcellular locations from COMPARTMENTS for NAT6 Gene

Pathways & Interactions for NAT6 Gene

No Data Available

Interacting Proteins for NAT6 Gene

Selected Interacting proteins: Q93015-NAT6_HUMAN for NAT6 Gene via IID

Gene Ontology (GO) - Biological Process for NAT6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAT6 Gene

Drugs & Compounds for NAT6 Gene

(1) Additional Compounds for NAT6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Hydroxyphenylacetyl-CoA
  • [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
117411-05-9
genes like me logo Genes that share compounds with NAT6: view

Transcripts for NAT6 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT6 Gene

No ASD Table

Relevant External Links for NAT6 Gene

GeneLoc Exon Structure for
NAT6
ECgene alternative splicing isoforms for
NAT6

Expression for NAT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT6 Gene

mRNA differential expression in normal tissues according to GTEx for NAT6 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for NAT6 Gene

This gene is overexpressed in Ovary (37.8), Blymphocyte (13.6), and Frontal cortex (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NAT6 Gene



Protein tissue co-expression partners for NAT6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAT6 Gene:

NAT6

mRNA Expression by UniProt/SwissProt for NAT6 Gene:

Q93015-NAT6_HUMAN
Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta.

Evidence on tissue expression from TISSUES for NAT6 Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with NAT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT6 Gene

Orthologs for NAT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT6 34 35
  • 99.03 (n)
dog
(Canis familiaris)
Mammalia NAT6 34
  • 86.27 (n)
rat
(Rattus norvegicus)
Mammalia LOC100910872 34
  • 83.22 (n)
mouse
(Mus musculus)
Mammalia Nat6 34 16 35
  • 81.14 (n)
cow
(Bos Taurus)
Mammalia NAT6 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAT6 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAT6 35
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAT6 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886319 34
  • 52.69 (n)
NAT6 35
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8481 35
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C56G2.15 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToOne
Species where no ortholog for NAT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAT6 Gene

ENSEMBL:
Gene Tree for NAT6 (if available)
TreeFam:
Gene Tree for NAT6 (if available)

Paralogs for NAT6 Gene

(1) SIMAP similar genes for NAT6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NAT6: view

No data available for Paralogs for NAT6 Gene

Variants for NAT6 Gene

Sequence variations from dbSNP and Humsavar for NAT6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs200439690 Non-small cell lung cancer cell lines 50,296,844(+) GCAGG(A/C/G)TGGCA intron-variant, reference, missense
VAR_014224 Non-small cell lung cancer cell lines
rs117179004 Likely benign 50,300,616(+) CAGGC(A/G)TGAGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs1283 Likely benign 50,299,991(-) GGGTA(C/T)AGCCC nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs142342237 Uncertain significance 50,300,514(+) ACGGT(C/G)CCTGC nc-transcript-variant, upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NAT6 Gene

Variant ID Type Subtype PubMed ID
dgv8316n54 CNV loss 21841781
dgv8317n54 CNV loss 21841781
esv2759148 CNV loss 17122850
nsv3813 CNV deletion 18451855
nsv460531 CNV loss 19166990
nsv470561 CNV loss 18288195
nsv523560 CNV loss 19592680
nsv523662 CNV loss 19592680
nsv590255 CNV loss 21841781
nsv834692 CNV loss 17160897
nsv834693 CNV loss 17160897
nsv954855 CNV deletion 24416366

Variation tolerance for NAT6 Gene

Residual Variation Intolerance Score: 76.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.20; 69.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT6 Gene

Disorders for NAT6 Gene

Relevant External Links for NAT6

Genetic Association Database (GAD)
NAT6
Human Genome Epidemiology (HuGE) Navigator
NAT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT6

No disorders were found for NAT6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT6 Gene

Publications for NAT6 Gene

  1. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. (PMID: 15036368) Duh F.M. … Lerman M.I. (Mol. Cell. Probes 2004) 3 22 46 64
  2. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PMID: 11085536) Lerman M.I. … Minna J.D. (Cancer Res. 2000) 2 3 4 64
  3. The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PMID: 10644992) Zegerman P. … Kouzarides T. (Oncogene 2000) 3 4 22 64
  4. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PMID: 19789190) Young R.P. … Gamble G.D. (Postgrad Med J 2009) 3 46 64
  5. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 3 4 64

Products for NAT6 Gene

Sources for NAT6 Gene

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