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NAT6 Gene

protein-coding   GIFtS: 48
GCID: GC03M050333

N-Acetyltransferase 6 (GCN5-Related)

(Previous name: N-acetyltransferase 6)
  See NAT6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetyltransferase 6 (GCN5-Related)1 2     FUS-22
FUS22 3 5     EC 2.3.1.-3
N-Acetyltransferase 61 2     Protein Fus-23
Protein Fusion-22 3     

External Ids:    HGNC: 302521   Entrez Gene: 241422   Ensembl: ENSG000002434777   OMIM: 6070735   UniProtKB: Q930153   

Export aliases for NAT6 gene to outside databases

Previous GC identifers: GC03M050293 GC03M050300 GC03M050308


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAT6 Gene:
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring
acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic
N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located
in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer.
Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and
is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the
first exon. (provided by RefSeq, Jan 2011)

GeneCards Summary for NAT6 Gene:
NAT6 (N-acetyltransferase 6 (GCN5-related)) is a protein-coding gene. Diseases associated with NAT6 include lung cancer susceptibility, and lung cancer. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015
Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn.
May act as a tumor suppressor




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NAT6 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NAT6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

NAT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT6 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050333:  view genomic region     (about GC identifiers)

Start:
50,333,833 bp from pter      End:
50,336,852 bp from pter
Size:
3,020 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015 (See protein sequence)
Recommended Name: N-acetyltransferase 6  
Size: 286 amino acids; 31445 Da
Secondary accessions: Q93014
Alternative splicing: 2 isoforms:  Q93015-1   Q93015-2   

Explore the universe of human proteins at neXtProt for NAT6: NX_Q93015

Explore proteomics data for NAT6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NAT6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186945.1  NP_001186947.1  NP_036323.2  

    ENSEMBL proteins: 
     ENSP00000346927   ENSP00000391893   ENSP00000410610   ENSP00000400559   ENSP00000388316  
     ENSP00000391158   ENSP00000413623  

    NAT6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NAT6
    OriGene Protein Over-expression Lysate for NAT6
    OriGene MassSpec for NAT6
    OriGene Custom Protein Services for NAT6
    GenScript Custom Purified and Recombinant Proteins Services for NAT6
    Novus Biologicals NAT6 Proteins
    Novus Biologicals NAT6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NAT6
    Cloud-Clone Corp. Proteins for NAT6

     
    Search eBioscience for Proteins for NAT6 

    NAT6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NAT6 Antibodies
    Abcam antibodies for NAT6
    Cloud-Clone Corp. Antibodies for NAT6
    ThermoFisher Antibodies for NAT6
    LSBio Antibodies in human, mouse, rat for NAT6

    NAT6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAT6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAT6
    Cloud-Clone Corp. CLIAs for NAT6
    Search eBioscience for ELISAs for NAT6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q93015

    ProtoNet protein and cluster: Q93015

    1 Blocks protein domain: IPB000182 GCN5-related N-acetyltransferase

    UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015
    Similarity: Belongs to the acetyltransferase family
    Similarity: Contains 1 N-acetyltransferase domain


    Find genes that share domains with NAT6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAT6_HUMAN, Q93015
    Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn.
    May act as a tumor suppressor

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008080N-acetyltransferase activity IEA--
         
    Find genes that share ontologies with NAT6           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAT6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAT6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAT6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAT6

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAT6:
    hsa-mir-124-3p (MIRT022873)

    Block miRNA regulation of human, mouse, rat NAT6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NAT6:
    hsa-miR-4303 hsa-miR-3157-5p hsa-miR-3921 hsa-miR-874
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAT6
    Predesigned siRNA for gene silencing in human, mouse, rat NAT6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAT6

    Clone
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    OriGene clones in human, mouse for NAT6 (see all 8)
    OriGene ORF clones in mouse, rat for NAT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NAT6 (NM_001200018)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT6

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NAT6
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAT6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAT6_HUMAN, Q93015: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol3
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----

    Find genes that share ontologies with NAT6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAT6
    Interactions:

        Search GeneGlobe Interaction Network for NAT6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for NAT6 (Q930153 ENSP000003469274) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EMG1Q929793I2D: score=3 
    SUSD4Q5VX713I2D: score=1 
    FAM107BENSP000001817964STRING: ENSP00000181796
    --ENSP000002614064STRING: ENSP00000261406
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAT6

    1 HMDB Compound for NAT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    4-Hydroxyphenylacetyl-CoA[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid 117411-05-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAT6 gene (3 alternative transcripts): 
    NM_001200016.1  NM_001200018.1  NM_012191.3  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354862(uc003czj.3) ENST00000417393(uc003czi.3) ENST00000443094(uc003czk.4)
    ENST00000443842 ENST00000450489 ENST00000442620 ENST00000452674
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAT6 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NAT6:
    hsa-miR-4303 hsa-miR-3157-5p hsa-miR-3921 hsa-miR-874
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAT6
    Predesigned siRNA for gene silencing in human, mouse, rat NAT6
    Clone
    Products:
         
    OriGene clones in human, mouse for NAT6 (see all 8)
    OriGene ORF clones in mouse, rat for NAT6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NAT6 (NM_001200018)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAT6
    OriGene qSTAR qPCR primer pairs in human, mouse for NAT6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT6
      QuantiTect SYBR Green Assays in human, mouse, rat NAT6
      QuantiFast Probe-based Assays in human, mouse, rat NAT6

    Selected AceView cDNA sequences (see all 510):

    BM874367 AW167702 BQ015396 BU621065 CR608020 BU741074 BM918332 AW409968 
    BE904712 BM791438 CB305671 CR621832 AF502911 BC007265 AI584127 BU952179 
    AI268721 AA513313 AF040706 AA594570 BM976273 AF040710 AA370735 AI583049 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NAT6 Expression
    About this image

    NAT6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAT6 Protein Expression

    UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015
    Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak
    expression in kidney, liver, and lung and no expression in placenta

        Custom PCR Arrays for NAT6
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    OriGene qPCR primer pairs and template standards for NAT6
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    QuantiFast Probe-based Assays in human, mouse, rat NAT6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NAT6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nat61 , 5 N-acetyltransferase 61, 5 81.14(n)1
    73.36(a)1
      9 (58.18 cM)5
    564411  NM_019750.31  NP_062724.11 
     1075788875 
    lizard
    (Anolis carolinensis)
    Reptilia NAT66
    N-acetyltransferase 6 (GCN5-related)
    47(a)
    1 ↔ 1
    2(149872157-149873095)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018863191 N-acetyltransferase 6-like 52.69(n)
    50.97(a)
      101886319  XM_005167127.1  XP_005167184.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84816
    --
    32(a)
    1 ↔ 1
    3R(5593573-5595749)
    worm
    (Caenorhabditis elegans)
    Secernentea C56G2.156
    Protein C56G2.15 (C56G2.15) mRNA, complete cds
    27(a)
    1 ↔ 1
    III(6366581-6367822) WBGene00016983


    ENSEMBL Gene Tree for NAT6 (if available)
    TreeFam Gene Tree for NAT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAT6 gene
    1 SIMAP similar gene for NAT6 using alignment to 3 protein entries:     NAT6_HUMAN (see all proteins):
    HYAL3

    Find genes that share paralogs with NAT6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    2 SNPs for NAT6    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0142254
    Non-small cell lung cancer cell lines4--see VAR_0142252 T S mis40--------
    VAR_0142244
    Non-small cell lung cancer cell lines4--see VAR_0142242 R S mis40--------

    HapMap Linkage Disequilibrium report for NAT6 (50333833 - 50336852 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NAT6 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5132n71CNV Loss21882294
    nsv523662CNV Loss19592680
    nsv876770CNV Loss21882294
    nsv3813CNV Loss18451855
    dgv5131n71CNV Loss21882294
    nsv876769CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv470561CNV Loss18288195
    nsv834693CNV Loss17160897
    nsv523560CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAT6
    DNA2.0 Custom Variant and Variant Library Synthesis for NAT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607073    OMIM disorders: --

    2 diseases for NAT6:    
    About MalaCards
    lung cancer susceptibility    lung cancer


    Find genes that share disorders with NAT6           About GenesLikeMe

    2 Novoseek inferred disease relationships for NAT6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0.79 2 10644992 (1)
    tumors 0 3 15276206 (1), 15036368 (1)

    Genetic Association Database (GAD): NAT6
    Human Genome Epidemiology (HuGE) Navigator: NAT6 (4 documents)

    Export disorders for NAT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAT6 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with NAT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2, 3 Lerman M.I. and Minna J.D. (Cancer Res. 2000)
    2. The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PubMed id 10644992)1, 2, 9 Zegerman P.... Kouzarides T. (Oncogene 2000)
    3. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. (PubMed id 15036368)1, 4, 9 Duh F.M....Lerman M.I. (Mol. Cell. Probes 2004)
    4. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PubMed id 19789190)1, 4 Young R.P....Gamble G.D. (Postgrad Med J 2009)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. (PubMed id 11929860)1, 3 Shuttleworth T.L....Triggs-Raine B.L. (J. Biol. Chem. 2002)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas. (PubMed id 15885884)1 Yi Lo P.H....Lung M.L. (Cancer Lett. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24142 HGNC: 30252 AceView: HYAL3 Ensembl:ENSG00000243477 euGenes: HUgn24142
    ECgene: NAT6 H-InvDB: NAT6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAT6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAT6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAT6 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Search Addgene for plasmids for NAT6
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