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Aliases for NAT6 Gene

Aliases for NAT6 Gene

  • N-Acetyltransferase 6 (GCN5-Related) 2 3
  • FUS2 3 4 6
  • N-Acetyltransferase 6 2 3
  • Protein Fusion-2 3 4
  • Protein Fus-2 4
  • EC 2.3.1.- 4
  • FUS-2 3

External Ids for NAT6 Gene

Summaries for NAT6 Gene

Entrez Gene Summary for NAT6 Gene

  • This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

GeneCards Summary for NAT6 Gene

NAT6 (N-Acetyltransferase 6 (GCN5-Related)) is a Protein Coding gene. Diseases associated with NAT6 include lung cancer. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT6 Gene

  • Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT6 Gene

Genomics for NAT6 Gene

Genomic Location for NAT6 Gene

Start:
50,296,402 bp from pter
End:
50,299,421 bp from pter
Size:
3,020 bases
Orientation:
Minus strand

Genomic View for NAT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT6 Gene

Regulatory Elements for NAT6 Gene

Transcription factor binding sites by QIAGEN in the NAT6 gene promoter:

Proteins for NAT6 Gene

  • Protein details for NAT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q93015-NAT6_HUMAN
    Recommended name:
    N-acetyltransferase 6
    Protein Accession:
    Q93015
    Secondary Accessions:
    • Q93014

    Protein attributes for NAT6 Gene

    Size:
    286 amino acids
    Molecular mass:
    31445 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NAT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT6 Gene

Proteomics data for NAT6 Gene at MOPED

Post-translational modifications for NAT6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NAT6 Gene

Domains for NAT6 Gene

Protein Domains for NAT6 Gene

Suggested Antigen Peptide Sequences for NAT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q93015

UniProtKB/Swiss-Prot:

NAT6_HUMAN
Domain:
  • Contains 1 N-acetyltransferase domain.:
    • Q93015
Family:
  • Belongs to the acetyltransferase family.:
    • Q93015
genes like me logo Genes that share domains with NAT6: view

No data available for Gene Families for NAT6 Gene

Function for NAT6 Gene

Molecular function for NAT6 Gene

UniProtKB/Swiss-Prot Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor.

Enzyme Numbers (IUBMB) for NAT6 Gene

Gene Ontology (GO) - Molecular Function for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with NAT6: view

miRNA for NAT6 Gene

miRTarBase miRNAs that target NAT6

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAT6 Gene

Localization for NAT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT6 Gene COMPARTMENTS Subcellular localization image for NAT6 gene
Compartment Confidence
mitochondrion 4
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NAT6: view

Pathways for NAT6 Gene

SuperPathways for NAT6 Gene

No Data Available

Interacting Proteins for NAT6 Gene

Selected Interacting proteins: Q93015-NAT6_HUMAN for NAT6 Gene via I2D

Symbol External ID(s) Details
EMG1
SUSD4

Gene Ontology (GO) - Biological Process for NAT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAT6: view

No data available for Pathways by source for NAT6 Gene

Compounds for NAT6 Gene

(1) HMDB Compounds for NAT6 Gene

Compound Synonyms Cas Number PubMed IDs
4-Hydroxyphenylacetyl-CoA
  • [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
117411-05-9
genes like me logo Genes that share compounds with NAT6: view

Transcripts for NAT6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NAT6 Gene

No ASD Table

Relevant External Links for NAT6 Gene

GeneLoc Exon Structure for
NAT6
ECgene alternative splicing isoforms for
NAT6

Expression for NAT6 Gene

mRNA expression in normal human tissues for NAT6 Gene

mRNA differential expression in normal tissues according to GTEx for NAT6 Gene

This gene is overexpressed in Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NAT6 Gene

mRNA Expression by UniProt/SwissProt for NAT6 Gene

Q93015-NAT6_HUMAN
Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weak expression in kidney, liver, and lung and no expression in placenta
genes like me logo Genes that share expressions with NAT6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NAT6 Gene

Orthologs for NAT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NAT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT6 35
  • 99.03 (n)
  • 97.08 (a)
NAT6 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAT6 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAT6 35
  • 86.27 (n)
  • 83.53 (a)
mouse
(Mus musculus)
Mammalia Nat6 35
  • 81.14 (n)
  • 73.36 (a)
Nat6 16
Nat6 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAT6 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAT6 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100910872 35
  • 83.22 (n)
  • 77.11 (a)
lizard
(Anolis carolinensis)
Reptilia NAT6 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886319 35
  • 52.69 (n)
  • 50.97 (a)
NAT6 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8481 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C56G2.15 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for NAT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAT6 Gene

ENSEMBL:
Gene Tree for NAT6 (if available)
TreeFam:
Gene Tree for NAT6 (if available)

Paralogs for NAT6 Gene

Selected SIMAP similar genes for NAT6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NAT6: view

No data available for Paralogs for NAT6 Gene

Variants for NAT6 Gene

Sequence variations from dbSNP and Humsavar for NAT6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_014224 Non-small cell lung cancer cell lines
VAR_014225 Non-small cell lung cancer cell lines

Structural Variations from Database of Genomic Variants (DGV) for NAT6 Gene

Variant ID Type Subtype PubMed ID
nsv523662 CNV Loss 19592680
nsv876769 CNV Loss 21882294
nsv470561 CNV Loss 18288195
nsv876770 CNV Loss 21882294
nsv523560 CNV Loss 19592680
dgv1456e1 CNV Complex 17122850
nsv834692 CNV Loss 17160897
nsv460531 CNV Loss 19166990
dgv5131n71 CNV Loss 21882294
dgv5132n71 CNV Loss 21882294
nsv834693 CNV Loss 17160897
nsv3813 CNV Loss 18451855

Relevant External Links for NAT6 Gene

HapMap Linkage Disequilibrium report
NAT6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT6 Gene

Disorders for NAT6 Gene

(1) MalaCards Diseases for NAT6 Gene

Search for NAT6 Gene in MalaCards »

(2) Novoseek inferred disease relationships for NAT6 Gene

Disease -log(P) Hits PubMed IDs
cancer 0.79 1
tumors 0 2

Relevant External Links for NAT6

Genetic Association Database (GAD)
NAT6
Human Genome Epidemiology (HuGE) Navigator
NAT6
genes like me logo Genes that share disorders with NAT6: view

No data available for UniProtKB/Swiss-Prot for NAT6 Gene

Publications for NAT6 Gene

  1. The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PMID: 10644992) Zegerman P. … Kouzarides T. (Oncogene 2000) 3 4 23
  2. Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. (PMID: 15036368) Duh F.M. … Lerman M.I. (Mol. Cell. Probes 2004) 3 23 48
  3. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PMID: 11085536) Lerman M.I. … Minna J.D. (Cancer Res. 2000) 2 3 4
  4. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. (PMID: 11929860) Shuttleworth T.L. … Triggs-Raine B.L. (J. Biol. Chem. 2002) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NAT6 Gene

Sources for NAT6 Gene

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