NAT6 Gene
protein-coding GIFtS: 46
GCID: GC03M050333
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N-acetyltransferase 6 (GCN5-related)(Previous name: N-acetyltransferase 6 )
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Aliases
for NAT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Acetyltransferase 6 (GCN5-Related)1 2 | | FUS-22 | | FUS21 2 3 5 | | EC 2.3.1.-3 | | N-Acetyltransferase 61 2 | | Protein Fus-23 | | Protein Fusion-22 3 | | |
Export aliases for NAT6 gene to outside databasesPrevious GC identifers: GC03M050293 GC03M050300 GC03M050308 |
Summaries
for NAT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAT6:
This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferringacetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmicN-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located inthe tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternativelyspliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the samestrand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. (providedby RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. Mayact as a tumor suppressor
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Genomic Views
for NAT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAT6 gene promoter:
ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAT6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3NAT6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M050333: view genomic region
(about GC identifiers)
Start:
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50,333,833 bp from pter |
End:
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50,336,852 bp from pter |
Size:
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3,020 bases |
Orientation:
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minus strand |
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Proteins
for NAT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015 (See
protein sequence)Recommended Name: N-acetyltransferase 6 Size: 286 amino acids; 31445 Da
Subcellular location: Cytoplasm
Secondary accessions: Q93014Alternative splicing: 2 isoforms: Q93015-1 Q93015-2 Explore the universe of human proteins at neXtProt for NAT6: NX_Q93015
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q93015
NAT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186945.1 NP_001186947.1 NP_036323.2
ENSEMBL proteins: ENSP00000346927 ENSP00000391893 ENSP00000410610 ENSP00000400559 ENSP00000388316 ENSP00000391158 ENSP00000413623
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
NAT6 for ontologies About GeneDecksing
NAT6 Antibody Products:
Assay Products for NAT6: |
Protein
Domains /
Families
for NAT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAT6 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q93015ProtoNet protein and cluster: Q93015 1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase
UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015Similarity: Belongs to the acetyltransferase familySimilarity: Contains 1 N-acetyltransferase domain |
Function
for NAT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. Mayact as a tumor suppressorEnzyme Number (IUBMB): EC 2.3.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): NAT6 (NM_001200018) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008080 | N-acetyltransferase activity |
IEA | -- |
NAT6 for ontologies About GeneDecksing
|
Pathways & Interactions
for NAT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAT6
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
4 Interacting proteins for NAT6 (Q930153 ENSP000003469274) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for NAT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAT6
1 HMDB Compound for NAT6 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| 4-Hydroxyphenylacetyl-CoA | [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid | 117411-05-9 | -- |
Search CenterWatch for drugs/clinical trials and news about NAT6
|
Transcripts
for NAT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAT6 gene (3 alternative transcripts): NM_001200016.1 NM_001200018.1 NM_012191.3 7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000354862(uc003czj.3) ENST00000417393(uc003czi.3) ENST00000443094(uc003czk.4)
ENST00000443842 ENST00000450489 ENST00000442620 ENST00000452674
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NAT6 (NM_001200018) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAT6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT6 |
24/510 AceView cDNA sequences (see all 510): AA579404 AW960774 BE904712 BM918332 AI290004 BC007437 CR604048 AF036035 U09585 BU621396 BQ015396 BM673924 CR599544 CR595994 AW328741 BU509296 CB528453 BE272783 BC004483 AF502911 BX391065 NM_003549 CD367355 CF146834
GeneLoc Exon Structure
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Expression
for NAT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NAT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAT6
UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and pancreas, with weakexpression in kidney, liver, and lung and no expression in placenta
SABiosciences Custom PCR Arrays for NAT6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT6 |
Orthologs
for NAT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for NAT6 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for NAT6 (if available)
TreeFam Gene Tree for NAT6 (if available) |
Paralogs
for NAT6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NAT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NAT6
4 CNVs: 30176 4335 3429 4336 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT6 |
|
Disorders
/ Diseases
for NAT6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAT6 for disorders About GeneDecksing
OMIM gene information: 607073
OMIM disorders: --
6  diseases for NAT6: About MalaCardsalveolar soft part sarcoma sarcoma nasopharyngitis lung cancer
esophagitis arthritis
2 Novoseek disease relationships for NAT6 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0.79 |
2 |
10644992 (1) |
| tumors |
0 |
3 |
15276206 (1), 15036368 (1) |
Genetic Association Database (GAD): NAT6
Human Genome Epidemiology (HuGE) Navigator: NAT6 (4 documents)
Export disorders for NAT6 gene to outside databases
|
Publications
for NAT6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAT6 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with NAT6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)1, 2, 3 Lerman M.I. and Minna J.D. (2000)
- The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PubMed id 10644992)1, 2, 9 Zegerman P.... Kouzarides T. (2000)
- Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. (PubMed id 15036368)1, 4, 9 Duh F.M....Lerman M.I. (2004)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. (PubMed id 11929860)1, 3 Shuttleworth T.L....Triggs-Raine B.L. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- A gene-based risk score for lung cancer susceptibilit y in smokers and ex-smokers. (PubMed id 19789190)1 Young R.P....Gamble G.D. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcino mas. (PubMed id 15885884)1 Yi Lo P.H....Lung M.L. (2006)
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External Searches for NAT6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NAT6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAT6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAT6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NAT6 gene:
Search GeneIP for patents involving NAT6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAT6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for NAT6 | | OriGene shRNA RFP for NAT6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT6 | | | OriGene Protein Over-expression Lysate for NAT6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAT6 | | OriGene 3'-UTR Clone for NAT6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NAT6 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAT6 | | OriGene Custom Protein Services for NAT6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAT6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT6 |
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 |  |  |  | |
| | | | Search Tocris compounds for NAT6 |
| |  |  |  |  | | | | | | Recombinant Protein for NAT6 |
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 | | | NAT6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT6 |
|  |  |  | | | | ThermoFisher Antibodies for NAT6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT6 |
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