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NAT6 Gene

protein-coding GIFtS: 49

GC03M050308

N-acetyltransferase 6 (GCN5-related)
(Previous name: N-acetyltransferase 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.3.1.- ^³
FUS-2 ^²
FUS2 ^¹, ², ³

Descriptions
N-acetyltransferase 6 ^¹, ²
N-acetyltransferase 6 (GCN5-related) ^²
Protein fus-2 ^³
Protein fusion-2 ^³
putative tumor suppressor ^²

External Ids
HGNC: 30252¹
Entrez Gene: 24142²
UniProtKB: Q93015³
Ensembl: ENSG00000214699⁷

Search outside databases for aliases for NAT6 gene

Previous GC identifers: GC03M050293 GC03M050300

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015

Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by

Asp/Glu/Asn. May act as a tumor suppressor

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAT6 gene

Entrez Gene cytogenetic band: 3p21.3 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21.3

NAT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M050308: (about GC identifiers)

Start:	50,308,837 bp from pter
End:	50,311,716 bp from pter
Size:	2,880 bases
Orientation:	minus strand

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015 (See protein sequence)

Recommended Name: N-acetyltransferase 6

Size: 286 amino acids; 31445 Da

Subcellular location: Cytoplasm

Secondary accessions: Q93014

Alternative splicing: 2 isoforms: Q93015-1 Q93015-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_036323.2

ENSEMBL proteins:

ENSP00000346927

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FUS2)
	Human Recombinant Proteins from Abnova (NAT6)

OriGene Purified Recombinant Human Protein: NAT6

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for NAT6:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NAT6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (FUS2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NAT6)
	Novus Biologicals Antibody for HYAL3

Assays for NAT6:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q93015

ProtoNet protein and cluster: Q93015

1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase

UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015

Similarity: Belongs to the acetyltransferase family

Similarity: Contains 1 N-acetyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAT6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012191

Applied Biosystems Silencer® siRNAs for NAT6

Sigma-Aldrich siRNA for NAT6

Sigma-Aldrich shRNA for NAT6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAT6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_012191
Myc/DDK tagged cDNA clone in CMV expression vector: NM_012191
untagged cDNA clones in CMV expression vector (see all 2): NM_012191

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_012191

UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015

Function: Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by

Asp/Glu/Asn. May act as a tumor suppressor

Enzyme Number (IUBMB): EC 2.3.1.-

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008080	N-acetyltransferase activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--
GO:0045786	negative regulation of cell cycle	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT6

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAT6)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_012191

Sigma-Aldrich siRNA for NAT6

Sigma-Aldrich shRNA for NAT6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012191

REFSEQ mRNAs for NAT6 gene:

NM_012191.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012191

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_012191
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_012191
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_012191

24/510 AceView cDNA sequences (see all 510 ):

BC035689 AA948544 BG575729 BG828990 BG574877 AA991634 CB305671 BX952620

NM_006764 BE264254 BP364738 BU191968 AF502910 AI268721 BM806185 BM793195

AA594445 BE904712 BM796989 AA857646 BG760348 BF346307 BG057830 AI583621

highest scoring ESTs for NAT6:

AF040705 AL525916 BC004483 BE563312 BG761394 BX419839 AA833631 AA913362 AA937194 AF040706

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000354862

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAT6

¹ / ² / ³

3 probe-sets matching NAT6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39238_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF040705	0.60	0.58	0.59	1
210874_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC004483	0.60	0.46	0.53	1
210874_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAT6 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTCCTGGGT
Expression variation in blood from EXPOLDB for NAT6
UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015
Tissue specificity: Strongly expressed in heart and skeletal muscle, followed by brain and
pancreas, with weak expression in kidney, liver, and lung and no expression in placenta

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAT6 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAT6¹	--	N-acetyltransferase 6 (GCN5-related)	85.73(n) 82.03(a)	608612 XM_845689.1 XP_850782.1
mouse (Mus musculus)	Nat6^{1, 5}	9 (60.15 cM)⁵	N-acetyltransferase 6^{1, 5}	81.14(n)¹ 73.36(a)¹	56441¹ NM_019750.3¹ NP_062724.1¹ AF172275⁵ AF296733⁵ (see all 18)
zebrafish (Danio rerio)	LOC100004600¹	--	similar to N-acetyltransferase 6 (Fus-2 protein) (Fusion more	51.42(n) 49.78(a)	100004600 XM_001343824.2 XP_001343860.2

About this table Species with no ortholog for NAT6

ENSEMBL Gene Tree for NAT6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 607073

UniProtKB/Swiss-Prot: NAT6_HUMAN, Q93015

Defects in NAT6 are found in non-small cell lung cancer (NSCLC) cell lines

2 Novoseek disease relationships for NAT6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	2.34	2	10644992 (1)
tumors	0.00	3	15276206 (1), 15036368 (1)

About this table

Genetic Association Database: NAT6
Human Genome Epidemiology Navigator: NAT6 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/15 PubMed articles for NAT6 gene (see all 15 ):

The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. (PubMed id 11085536)^{2, 3, 4} Lerman M.I. and Minna J.D. (2000)
The putative tumour suppressor Fus-2 is an N-acetyltransferase. (PubMed id 10644992)^{1, 3, 4} Zegerman P.... Kouzarides T. (2000)
Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer. (PubMed id 15036368)^{1, 3, 6} Duh F.M....Lerman M.I. (2004)
The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)^{3, 4} Muzny D.M....Gibbs R.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. (PubMed id 11929860)^{2, 3} Shuttleworth T.L....Triggs-Raine B.L. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Structural and expression analysis of the porcine FUS2 gene. (PubMed id 15276206)¹ Gatphayak K....Brenig B. (2004)
Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma. (PubMed id 18176180)¹ Vistica D.T....Shoemaker R.H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 24142	HGNC: 30252	AceView: HYAL3	Ensembl:ENSG00000214699	euGenes: HUgn24142
ECgene: NAT6	H-InvDB: NAT6

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NAT6	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NAT6
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAT6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAT6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAT6		Antibodies for NAT6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAT6		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAT6)
	Antibodies (NAT6)
	Chimera RNAi (NAT6)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (FUS2)
	Antibodies (FUS2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NAT6

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for HYAL3

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NAT6 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for NAT6

Summaries
for NAT6

Genomic Location
for NAT6

Proteins
for NAT6

Protein Domains/
Families
for NAT6

Gene Function
for NAT6

Pathways & Interactions
for NAT6

Drugs & Compounds
for NAT6

Transcripts
for NAT6

Expression
for NAT6

Orthologs
for NAT6

Paralogs
for NAT6

SNPs/Variants
for NAT6

Disorders & Mutations
for NAT6

Medical News
for NAT6

Publications
for NAT6

Search for NAT6

Genome Databases showing NAT6

Other Databases showing NAT6

Specialized Databases showing NAT6

Licensable Technologies
for NAT6

Services
for NAT6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAT6 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor NAT6

Summariesfor NAT6

Genomic Locationfor NAT6

Proteinsfor NAT6

Protein Domains/Familiesfor NAT6

Gene Functionfor NAT6

Pathways & Interactionsfor NAT6

Drugs & Compoundsfor NAT6

Transcriptsfor NAT6

Expression for NAT6

Orthologsfor NAT6

Paralogsfor NAT6

SNPs/Variantsfor NAT6

Disorders & Mutationsfor NAT6

Medical Newsfor NAT6

Publicationsfor NAT6

Search for NAT6

Genome Databases showing NAT6

Other Databases showing NAT6

Specialized Databases showing NAT6

Licensable Technologiesfor NAT6

Servicesfor NAT6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAT6

Summaries
for NAT6

Genomic Location
for NAT6

Proteins
for NAT6

Protein Domains/
Families
for NAT6

Gene Function
for NAT6

Pathways & Interactions
for NAT6

Drugs & Compounds
for NAT6

Transcripts
for NAT6

Expression
for NAT6

Orthologs
for NAT6

Paralogs
for NAT6

SNPs/Variants
for NAT6

Disorders & Mutations
for NAT6

Medical News
for NAT6

Publications
for NAT6

Licensable Technologies
for NAT6

Services
for NAT6