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Aliases for NAT2 Gene

Aliases for NAT2 Gene

  • N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) 2 3 5
  • N-Acetyltransferase Type 2 3 4
  • Arylamide Acetylase 2 3 4
  • EC 2.3.1.5 4 63
  • NAT-2 3 4
  • AAC2 3 4
  • PNAT 3 4
  • Polymorphic Arylamine N-Acetyltransferase 4

External Ids for NAT2 Gene

Previous HGNC Symbols for NAT2 Gene

  • AAC2

Previous GeneCards Identifiers for NAT2 Gene

  • GC08P018125
  • GC08P018311
  • GC08P018259
  • GC08P018293
  • GC08P016793
  • GC08P018250

Summaries for NAT2 Gene

Entrez Gene Summary for NAT2 Gene

  • This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]

GeneCards Summary for NAT2 Gene

NAT2 (N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)) is a Protein Coding gene. Diseases associated with NAT2 include nat2-related altered drug metabolism and drug-induced hepatitis. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include acetyltransferase activity and arylamine N-acetyltransferase activity. An important paralog of this gene is NAT1.

UniProtKB/Swiss-Prot for NAT2 Gene

  • Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Gene Wiki entry for NAT2 Gene

PharmGKB "VIP" Summary for NAT2 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for NAT2 Gene

Genomics for NAT2 Gene

Regulatory Elements for NAT2 Gene

Genomic Location for NAT2 Gene

Chromosome:
8
Start:
18,391,245 bp from pter
End:
18,401,219 bp from pter
Size:
9,975 bases
Orientation:
Plus strand

Genomic View for NAT2 Gene

Genes around NAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT2 Gene

Proteins for NAT2 Gene

  • Protein details for NAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11245-ARY2_HUMAN
    Recommended name:
    Arylamine N-acetyltransferase 2
    Protein Accession:
    P11245
    Secondary Accessions:
    • O43637
    • O60654
    • O60655
    • Q13146
    • Q16697
    • Q2MLE4
    • Q2MLF5
    • Q2MLG8
    • Q2MLJ6
    • Q2MLK4
    • Q2MLK6
    • Q2MLN7
    • Q6LET4
    • Q86XS0
    • Q86XS1
    • Q96KY8
    • Q96T64
    • Q96T65
    • Q9H220

    Protein attributes for NAT2 Gene

    Size:
    290 amino acids
    Molecular mass:
    33542 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK51711.1; Type=Frameshift; Positions=287; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAT2 Gene

neXtProt entry for NAT2 Gene

Proteomics data for NAT2 Gene at MOPED

Selected DME Specific Peptides for NAT2 Gene

Post-translational modifications for NAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NAT2 Gene

Gene Families for NAT2 Gene

Protein Domains for NAT2 Gene

Graphical View of Domain Structure for InterPro Entry

P11245

UniProtKB/Swiss-Prot:

ARY2_HUMAN :
  • Belongs to the arylamine N-acetyltransferase family.
Family:
  • Belongs to the arylamine N-acetyltransferase family.
genes like me logo Genes that share domains with NAT2: view

Function for NAT2 Gene

Molecular function for NAT2 Gene

GENATLAS Biochemistry:
arylamine N-acetyltransferase 2,polymorphic,responsible for slow or rapid acetylation of arylamine and hydrazine drugs,putative susceptibility factor in squamous-cell carcinoma of the esophagus,also involved in bladder carcinogenesis and breast cancer
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
UniProtKB/Swiss-Prot Function:
Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens.

Enzyme Numbers (IUBMB) for NAT2 Gene

Gene Ontology (GO) - Molecular Function for NAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016407 acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with NAT2: view
genes like me logo Genes that share phenotypes with NAT2: view

Animal Models for NAT2 Gene

MGI Knock Outs for NAT2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NAT2 Gene

Localization for NAT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT2 Gene COMPARTMENTS Subcellular localization image for NAT2 gene
Compartment Confidence
cytosol 5
nucleus 2
plasma membrane 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NAT2 Gene

Pathways & Interactions for NAT2 Gene

genes like me logo Genes that share pathways with NAT2: view

Interacting Proteins for NAT2 Gene

Gene Ontology (GO) - Biological Process for NAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAT2: view

No data available for SIGNOR curated interactions for NAT2 Gene

Drugs & Compounds for NAT2 Gene

(50) Drugs for NAT2 Gene - From: Novoseek, HMDB, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isoniazid Approved Pharma Enzyme, substrate 142
Acetaminophen Approved Pharma Enzyme, inhibitor 864
Dapsone Approved, Investigational Pharma Enzyme, substrate 62
Hydralazine Approved Pharma 42
Rifampicin Approved Pharma Agonist Pregnane X receptor agonist; antibiotic 303

(66) Additional Compounds for NAT2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
Acetylisoniazid
  • (N)1-Acetylisoniazid
  • 1-Acetyl-2-isonicotinoylhydrazine
  • Acetyl isoniazid
  • Acetylisoniazid
  • N'-Acetylpyridine-4-carbohydrazide
1078-38-2
Paraxanthine
  • 1,7-Dimethyl-Xanthine
  • 1,7-Dimethylxanthine
611-59-6
2,4-Diamino-6-nitrotoluene
3-Aminosalicylic acid
  • 3-Amino Salicylate
  • 3-Amino Salicylic acid
  • 3-Amino-(8CI)salicylate
  • 3-Amino-(8CI)salicylic acid
  • 3-Amino-2-hydroxy-(9CI)benzoate
570-23-0
genes like me logo Genes that share compounds with NAT2: view

Transcripts for NAT2 Gene

mRNA/cDNA for NAT2 Gene

Unigene Clusters for NAT2 Gene

N-acetyltransferase 2 (arylamine N-acetyltransferase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT2 Gene

No ASD Table

Relevant External Links for NAT2 Gene

GeneLoc Exon Structure for
NAT2
ECgene alternative splicing isoforms for
NAT2

Expression for NAT2 Gene

mRNA expression in normal human tissues for NAT2 Gene

mRNA differential expression in normal tissues according to GTEx for NAT2 Gene

This gene is overexpressed in Liver (x38.0) and Colon - Transverse (x6.1).

Protein differential expression in normal tissues from HIPED for NAT2 Gene

This gene is overexpressed in Gallbladder (42.7), Breast (11.3), and Liver (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAT2 Gene



SOURCE GeneReport for Unigene cluster for NAT2 Gene Hs.2

genes like me logo Genes that share expression patterns with NAT2: view

Protein tissue co-expression partners for NAT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NAT2 Gene

Orthologs for NAT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT2 36
  • 97 (a)
OneToOne
NAT2 35
  • 98.51 (n)
  • 96.55 (a)
cow
(Bos Taurus)
Mammalia NAT1 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nat1 16
Nat1 36
  • 72 (a)
ManyToMany
Nat2 36
  • 75 (a)
ManyToMany
Nat3 36
  • 66 (a)
ManyToMany
Nat1 35
  • 78.51 (n)
  • 71.72 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nat1 35
  • 79.08 (n)
  • 74.14 (a)
chicken
(Gallus gallus)
Aves NAT 36
  • 44 (a)
ManyToMany
PNAT10 36
  • 56 (a)
ManyToMany
PNAT3 36
  • 51 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-78a14.4 36
  • 40 (a)
ManyToMany
si:dkey-78a14.5 36
  • 39 (a)
ManyToMany
zgc:101040 36
  • 39 (a)
ManyToMany
zgc:103601 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
CSA.3273 36
  • 22 (a)
ManyToMany
Species with no ortholog for NAT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT2 Gene

ENSEMBL:
Gene Tree for NAT2 (if available)
TreeFam:
Gene Tree for NAT2 (if available)

Paralogs for NAT2 Gene

Paralogs for NAT2 Gene

Pseudogenes.org Pseudogenes for NAT2 Gene

genes like me logo Genes that share paralogs with NAT2: view

Variants for NAT2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NAT2 Gene

P11245-ARY2_HUMAN
Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity.

Sequence variations from dbSNP and Humsavar for NAT2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1801279 - 18,400,194(+) AAACY(A/G)GGGTG reference, missense
rs1801280 - 18,400,344(+) GACCA(C/T)TGACG reference, missense
rs1799930 - 18,400,593(+) ACCTC(A/G)AACAA reference, missense
rs1208 - 18,400,806(+) GCTGA(A/G)AAATA reference, missense
rs1799931 - 18,400,860(+) TGATG(A/G)ATCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NAT2 Gene

Variant ID Type Subtype PubMed ID
nsv428196 CNV Gain 18775914
dgv7747n71 CNV Loss 21882294
nsv831252 CNV Gain 17160897
nsv890605 CNV Loss 21882294

Variation tolerance for NAT2 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.88; 97.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT2 Gene

HapMap Linkage Disequilibrium report
NAT2
Human Gene Mutation Database (HGMD)
NAT2

Disorders for NAT2 Gene

MalaCards: The human disease database

(17) MalaCards diseases for NAT2 Gene - From: GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nat2-related altered drug metabolism
  • acetylation, slow
drug-induced hepatitis
  • drug-induced chronic hepatitis
isoniazid toxicity
urinary bladder cancer
  • bladder cancer
multiple chemical sensitivity
  • 20th century disease
- elite association - COSMIC cancer census association via MalaCards
Search NAT2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for NAT2 Gene

isoniazid inactivation

Relevant External Links for NAT2

Genetic Association Database (GAD)
NAT2
Human Genome Epidemiology (HuGE) Navigator
NAT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT2
genes like me logo Genes that share disorders with NAT2: view

No data available for UniProtKB/Swiss-Prot for NAT2 Gene

Publications for NAT2 Gene

  1. Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. (PMID: 18159984) Yoshida K. … Takahashi J. (Asian Pac. J. Cancer Prev. 2007) 3 23 48 67
  2. Phenotyping with sulfasalazine - time dependence and relation to NAT2 pharmacogenetics. (PMID: 20040334) Kuhn U.D. … Blume H.H. (Int J Clin Pharmacol Ther 2010) 3 23
  3. Genetic susceptibility factors for multiple chemical sensitivity revisited. (PMID: 20185366) Berg N.D. … Elberling J. (Int J Hyg Environ Health 2010) 3 23
  4. Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx). (PMID: 20004212) Metry K.J. … Hein D.W. (Mutat. Res. 2010) 3 23
  5. Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure. (PMID: 19909761) Teixeira R.L. … Santos A.R. (Mutat. Res. 2010) 3 23

Products for NAT2 Gene

Sources for NAT2 Gene

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