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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAT2 Gene

protein-coding   GIFtS: 66
GCID: GC08P018250

N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)


(Previous symbol: AAC2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)1 2     N-Acetyltransferase Type 22 3
AAC21 2 3 5     EC 2.3.1.53 8
Arylamide Acetylase 22 3     Arylamine N-Acetyltransferase 22
NAT-22 3     Polymorphic Arylamine N-Acetyltransferase3
PNAT2 3     

External Ids:    HGNC: 76461   Entrez Gene: 102   Ensembl: ENSG000001560067   OMIM: 6121825   UniProtKB: P112453   

Export aliases for NAT2 gene to outside databases

Previous GC identifers: GC08P018125 GC08P018311 GC08P018259 GC08P018293 GC08P016793


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAT2 Gene:
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and
carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human
populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are
also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene
(NAT1) is located near this gene (NAT2). (provided by RefSeq, Jul 2008)

GeneCards Summary for NAT2 Gene: 
NAT2 (N-acetyltransferase 2 (arylamine N-acetyltransferase)) is a protein-coding gene. Diseases associated with NAT2 include drug-induced hepatitis, and acetylation, slow, and among its related super-pathways are Phase II conjugation and Metabolic pathways. GO annotations related to this gene include arylamine N-acetyltransferase activity. An important paralog of this gene is NAT1.

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245
Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or
O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known
carcinogens

Gene Wiki entry for NAT2 (N-acetyltransferase 2) Gene

PharmGKB "VIP" summary for NAT2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAT2 gene promoter:
         PPAR-gamma1   p53   GR-alpha   PPAR-gamma2   Zic3   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

NAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P018250:  view genomic region     (about GC identifiers)

Start:
18,248,755 bp from pter      End:
18,258,728 bp from pter
Size:
9,974 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245 (See protein sequence)
Recommended Name: Arylamine N-acetyltransferase 2  
Size: 290 amino acids; 33542 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAK51711.1; Type=Frameshift; Positions=287;
1 PDB 3D structure from and Proteopedia for NAT2:
2PFR (3D)    
Secondary accessions: O43637 O60654 O60655 Q13146 Q16697 Q2MLE4 Q2MLF5 Q2MLG8 Q2MLJ6 Q2MLK4
Q2MLK6 Q2MLN7 Q6LET4 Q86XS0 Q86XS1 Q96KY8 Q96T64 Q96T65 Q9H220

Explore the universe of human proteins at neXtProt for NAT2: NX_P11245

Explore proteomics data for NAT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11245

  • 4/5 DME Specific Peptides for NAT2 (P11245) (see all 5)
     SFCSLQT  AYFERIGY  WYLDQIRR  RGGWCLQVN 

    NAT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAT2 Protein Expression
    REFSEQ proteins: NP_000006.2  
    ENSEMBL proteins: 
     ENSP00000286479   ENSP00000428416  
    Reactome Protein details: P11245
    Human Recombinant Protein Products for NAT2: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NAT2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NAT2
    GenScript Custom Purified and Recombinant Proteins Services for NAT2
    Novus Biologicals NAT2 Proteins
    Novus Biologicals NAT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NAT2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    NAT2 for ontologies           About GeneDecksing



    NAT2 Antibody Products: 
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    ThermoFisher Antibodies for NAT2
    LSBio Antibodies in human, mouse, rat for NAT2 

    Assay Products for NAT2: 
    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAT2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAT2 
    Cloud-Clone Corp. CLIAs for NAT2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001447 Arylamine_N-AcTrfase

    Graphical View of Domain Structure for InterPro Entry P11245

    ProtoNet protein and cluster: P11245

    1 Blocks protein domain: IPB004081 Arylamine N-acetyltransferase signature

    UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245
    Similarity: Belongs to the arylamine N-acetyltransferase family


    NAT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARY2_HUMAN, P11245
    Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or
    O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known
    carcinogens
    Catalytic activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

         Genatlas biochemistry entry for NAT2:
    arylamine N-acetyltransferase 2,polymorphic,responsible for slow or rapid acetylation of arylamine and hydrazine
    drugs,putative susceptibility factor in squamous-cell carcinoma of the esophagus,also involved in bladder
    carcinogenesis and breast cancer

         Enzyme Number (IUBMB): EC 2.3.1.51 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004060arylamine N-acetyltransferase activity IEA--
    GO:0016407acetyltransferase activity ----
         
    NAT2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NAT2:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nat1):
     homeostasis/metabolism  reproductive system 

    NAT2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nat1/Nat2Nat1/tm1Kss for NAT2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAT2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAT2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAT2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAT2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NAT2
    SwitchGear 3'UTR luciferase reporter plasmidNAT2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAT2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT2

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of NAT2

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for NAT2
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    GenScript: all cDNA clones in your preferred vector: NAT2 (NM_000015)
    Sino Biological Human cDNA Clone for NAT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT2
    Sirion Biotech Customized lentivirus for stable overexpression of NAT2 
                         Customized lentivirus expression plasmids for stable overexpression of NAT2 

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    Search LifeMap BioReagents cell lines for NAT2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NAT2 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.55
    metapathway biotransformation0.41
    Phase II conjugation0.55
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Caffeine Pathway, Pharmacokinetics
    Caffeine Pathway, Pharmacokinetics0.50
    Caffeine metabolism0.36
    4Drug metabolism - cytochrome P450
    Chemical carcinogenesis0.77
    5Acetaminophen metabolism
    Acetaminophen Pathway, Pharmacokinetics0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NAT2
        Arylamine metabolism
    metapathway biotransformation


    4        Reactome Pathways for NAT2
        Metabolism
    Biological oxidations
    Acetylation
    Phase II conjugation

    4 PharmGKB Pathways for NAT2
        Acetaminophen Pathway, Pharmacokinetics
    Benzodiazepine Pathway, Pharmacokinetics
    Busulfan Pathway, Pharmacodynamics
    Caffeine Pathway, Pharmacokinetics

    4         Kegg Pathways  (Kegg details for NAT2):
        Caffeine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways
    Chemical carcinogenesis


    NAT2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NAT2 (P112453 ENSP000002864794) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAA10P412273, ENSP000004177634I2D: score=1 STRING: ENSP00000417763
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    CYP2A13ENSP000003326794STRING: ENSP00000332679
    CYP2A6ENSP000003011414STRING: ENSP00000301141
    XDHENSP000003687274STRING: ENSP00000368727
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0044281small molecule metabolic process TAS--

    NAT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAT2 (ARY2)

    7 HMDB Compounds for NAT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Aminosalicylic acid3-Amino Salicylate (see all 16)570-23-0--
    5-Acetylamino-6-formylamino-3-methyluracil ----
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    AnilineAminobenzene (see all 16)62-53-3--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    N-AcetylarylamineN-Acetylarylamine 55576-55-1--
    Paraxanthine1,7-Dimethylxanthine (see all 2)611-59-6--

    6 DrugBank Compounds for NAT2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ClonazepamChlonazepam (see all 2)1622-61-3enzymesubstrate7273597 19356010
    AcetaminophenAcetaminofen (see all 5)103-90-2enzymeinhibitor9918139
    Dapsone1,1'-Sulfonylbis[4-aminobenzene] (see all 8)80-08-0enzymesubstrate19515014
    Ezogabine D-23129 (see all 5)150812-12-7enzymesubstrate23386597
    IsoniazidHIA (see all 13)54-85-3enzymesubstrate11703656
    Sulfamethoxazole-- 723-46-6enzymesubstrate19515014

    10/96 Novoseek inferred chemical compound relationships for NAT2 gene (see all 96)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arylamine 96.8 249 1996083 (3), 8081359 (3), 2376572 (2), 7995004 (2) (see all 99)
    afmu 93.2 39 10027663 (3), 11393735 (2), 12580991 (2), 1306111 (2) (see all 15)
    1-methylxanthine 89.6 33 10027663 (3), 12580991 (2), 14747882 (1), 8573631 (1) (see all 14)
    n-acetylsulfapyridine 86.8 6 12186410 (2), 15032315 (2)
    1,7-dimethyluric acid 85.4 6 10027663 (1), 11393735 (1), 12580991 (1), 17221922 (1)
    5-acetylamino-6-amino-3-methyluracil 85.3 11 14747882 (1), 8573631 (1), 11393735 (1), 11503005 (1) (see all 5)
    2-aminofluorene 81.5 12 11337936 (1), 16829624 (1), 8179482 (1), 9571233 (1) (see all 8)
    phip 81.1 46 19666988 (3), 15110095 (3), 19301197 (2), 11158715 (2) (see all 18)
    n-hydroxy phip 80.7 5 12773763 (2), 12016157 (1)
    n-hydroxy-2-aminofluorene 79.4 4 8425184 (2), 8353847 (1)

    8 PharmGKB related drug/compound annotations for NAT2 gene    About this table
    Drug/compound PharmGKB Annotation
    Drugs For Treatment Of TuberculosisCA  
    docetaxelCA  
    hydralazine
    isoniazid  CA  
    isosorbide dinitrate
    pyrazinamide
    rifampin
    thalidomideCA  

    Search CenterWatch for drugs/clinical trials and news about NAT2 / ARY2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAT2 gene: 
    NM_000015.2  

    Unigene Cluster for NAT2:

    N-acetyltransferase 2 (arylamine N-acetyltransferase)
    Hs.2  [show with all ESTs]
    Unigene Representative Sequence: BC067218
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286479(uc003wyw.1) ENST00000520116

    miRNA
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    GenScript: all cDNA clones in your preferred vector: NAT2 (NM_000015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT2

    Additional mRNA sequence: 

    AJ581144.1 AJ581145.1 AJ581146.1 AJ581147.1 BC015878.1 BC067218.1 CR407631.1 D90040.1 
    D90042.1 

    2 DOTS entries:

    DT.312018  DT.121480210 

    24/27 AceView cDNA sequences (see all 27):

    AU099534 CB161982 BV183942 AI792606 D90042 AI460128 D90040 BG563731 
    BC067218 NM_000015 BG617259 BU624903 BG618195 BV183943 BG569293 BC015878 
    AI733799 CR407631 CB161860 BG566307 BG533459 BG568400 BV183945 AI262683 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAT2 expression in normal human tissues (normalized intensities)      NAT2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGAAAACA
    NAT2 Expression
    About this image


    NAT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
             small intestine   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             testis ; cells in seminiferus ducts   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             bronchus ; respiratory epithelial cells   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; myoepithelial cells   
     
     Epithelium
             nasopharynx ; respiratory epithelial cells   

    See NAT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAT2

    SOURCE GeneReport for Unigene cluster: Hs.2
        SABiosciences Expression via Pathway-Focused PCR Arrays including NAT2: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NAT2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nat11 , 5 N-acetyl transferase 11, 5 78.51(n)1
    71.72(a)1
      8 (33.38 cM)5
    179601  NM_008673.11  NP_032699.11 
     674907585 
    chicken
    (Gallus gallus)
    Aves PNAT106
    PNAT36
    (see all 3)
    arylamine N-acetyltransferase, pineal gland isozym...
    Arylamine N-acetyltransferase, pineal gland isozym...
    (see all 3)
    56(a)
    51(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    11(15257513-15262027)
    11(15249011-15250817)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    53(a)
    1 → many
    GL343663.1(8584-9450)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-78a14.46
    zgc:1010406
    (see all 7)
    zgc:101040
    (see all 7)
    40(a)
    39(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    7(39641960-39649371)
    18(38776775-38781242)


    ENSEMBL Gene Tree for NAT2 (if available)
    TreeFam Gene Tree for NAT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAT2 gene
    NAT12  
    1 SIMAP similar gene for NAT2 using alignment to 31 protein entries:     ARY2_HUMAN (see all proteins):
    NAT1

    NAT2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAT2
    PGOHUM00000256796


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245
    Polymorphism: Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and
    influence drug therapy response and susceptibility to chemical toxicity or carcinogenicity


    10/369 SNPs in NAT2 are shown (see all 369)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18012801,2,4
    C,F,Hdrug-response118512735(+) GACCAT/CTGACG 2 /T /I mis1 ese339Minor allele frequency- C:0.35MN NA CSAM NS EA WA EU 9744
    rs17999301,2,4
    C,F,O,Hdrug-response118512984(+) ACCTCA/GAACAA 2 Q R mis1 ese351Minor allele frequency- N:0.00MN EA NA CSAM NS WA PA EU 11501
    rs12081,2,4
    C,F,A,Hdrug-response118513197(+) GCTGAA/GAAATA 2 K R mis1 ese351Minor allele frequency- G:0.36EA MN NA CSAM NS WA EU 10981
    rs17999311,2,4
    C,F,Hdrug-response118513251(+) TGATGG/AATCCC 2 /E /G mis1 ese341Minor allele frequency- A:0.05MN NA NS EA CSAM WA EU 10279
    VAR_0090764
    ----see VAR_0090762 Q P mis40--------
    VAR_0287814
    ----see VAR_0287812 T M mis40--------
    rs3750924521,2
    C--18247707(+) CCACA-/AGGAGTC 1 -- us2k10--------
    rs1427800391,2
    C--18252147(+) GTGAC-/CTTCTTTT 1 -- int10--------
    rs454718931,2
    C--18252150(+) ACCTTCTT/-TTACC 2 -- int1 cds12Minor allele frequency- -:0.27NS NA 180
    rs339921511,2
    C--18253461(+) TTTTTT/-GCAGT 1 -- int12Minor allele frequency- -:0.25NA 4

    HapMap Linkage Disequilibrium report for NAT2 (18248755 - 18258728 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NAT2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv890605CNV Loss21882294
    dgv7747n71CNV Loss21882294
    nsv831252CNV Gain17160897
    nsv428196CNV Gain18775914


    Human Gene Mutation Database (HGMD): NAT2

    Locus Specific Mutation Databases (LSDB): NAT2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NAT2
    DNA2.0 Custom Variant and Variant Library Synthesis for NAT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612182   
    OMIM disorders: 243400  
    20/124 diseases for NAT2 (see all 124):    About MalaCards
    drug-induced hepatitis    acetylation, slow    multiple chemical sensitivity    chromosome 8p deletion
    discoid lupus erythematosus    laryngitis    bladder cancer susceptibility    gilbert syndrome
    alcoholic liver cirrhosis    oral cavity cancer    laryngeal squamous cell carcinoma    breast disease
    liver cirrhosis    talipes equinovarus    alcoholic pancreatitis    behcet's disease
    mutagen sensitivity    spina bifida    laryngeal carcinoma    oral leukoplakia

    2 diseases from the University of Copenhagen DISEASES database for NAT2:
    Urinary bladder cancer     Tuberculosis

    NAT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/93 Novoseek inferred disease relationships for NAT2 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 74.9 184 10510890 (8), 15312364 (6), 10917561 (5), 9107426 (5) (see all 65)
    genetic susceptibility 63.5 19 12015038 (2), 12474054 (2), 10698723 (1), 11751440 (1) (see all 12)
    colorectal cancer 58.6 104 17525862 (7), 16434594 (6), 18159984 (6), 9301503 (4) (see all 41)
    cancer 56.6 157 15548945 (5), 10667461 (5), 12351146 (4), 9301503 (4) (see all 86)
    hepatitis toxic 55 3 20392357 (1), 19891553 (1)
    cancer lung 42.6 85 11815396 (5), 17477782 (5), 18706736 (5), 9731715 (4) (see all 27)
    colon cancer 41 27 9301503 (3), 9865425 (3), 16827944 (3), 11099063 (2) (see all 12)
    breast cancer 39.1 148 17535831 (6), 11008907 (6), 12708724 (5), 15609332 (5) (see all 41)
    chromosomal aberrations 35.3 15 10207633 (5), 10333536 (1), 10517994 (1), 15055296 (1) (see all 8)
    lupus erythematosus 32.9 4 12611196 (1), 10599336 (1), 9321764 (1)

    Genatlas disease: NAT2
    isoniazid inactivation

    Genetic Association Database (GAD): NAT2
    Human Genome Epidemiology (HuGE) Navigator: NAT2 (470 documents)

    Export disorders for NAT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAT2 gene, integrated from 9 sources (see all 1032):
    (articles sorted by number of sources associating them with NAT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of CYP1A1, CYP1A2, GSTM1 and NAT2 gene polymorphisms with colorectal cancer and smoking. (PubMed id 18159984)1, 4, 9 Yoshida K....Takahashi J. (2007)
    2. Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma. (PubMed id 17537267)1, 4, 9 Mahid S.S....Galandiuk S. (2007)
    3. N-acetyltransferase 2 (NAT2) gene polymorphisms in colon and lung cancer patients. (PubMed id 16827944)1, 4, 9 Borlak J. and Reamon-Buettner S.M. (2006)
    4. NAT2 polymorphism in Omani gastric cancer patients-risk predisposition and clinicopathological associations. (PubMed id 17569138)1, 4, 9 Al-Moundhri M.S....Tanira M. (2007)
    5. Glutathione S-transferase (GST) M1, T1 and N-acetyltransferase 2 (NAT2) polymorphisms and urothelial cancer risk with tobacco smoking. (PubMed id 15548945)1, 4, 9 Tsukino H....Katoh T. (2004)
    6. [Relationship between genetic polymorphism of NAT2 and susceptibility to urinary bladder cancer] (PubMed id 15312364)1, 4, 9 Hao G.Y....Zhang Y.H. (2004)
    7. Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequency in lung cancer patients and population controls. (PubMed id 11219770)1, 4, 9 Hou S.M....Lambert B. (2001)
    8. Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population. (PubMed id 15784508)1, 4, 9 Deguchi M....Maruo T. (2005)
    9. 'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. (PubMed id 15808403)1, 4, 9 Belogubova E.V....Imyanitov E.N. (2005)
    10. Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer. (PubMed id 14648207)1, 4, 9 Tsukino H....Katoh T. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10 HGNC: 7646 AceView: NAT2 Ensembl:ENSG00000156006 euGenes: HUgn10
    ECgene: NAT2 Kegg: 10 H-InvDB: NAT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAT2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAT2 Genetics and Cytogenetics in Oncology and Haematology
    NAThttp://www.louisville.edu/medschool/pharmacology/NAT.html
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nat2/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAT2 gene:
    Search GeneIP for patents involving NAT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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