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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NAT2 Gene

protein-coding GIFtS: 65
GCID: GC08P018250

N-acetyltransferase 2 (arylamine N-acetyltransferase)

(Previous symbol: AAC2)

Explore 135 diseases affiliated with
NAT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
N-Acetyltransferase 2 (Arylamine N-Acetyltransferase)¹ ²		N-Acetyltransferase Type 2² ³
AAC2¹ ² ³ ⁵		EC 2.3.1.5³ ⁸
Arylamide Acetylase 2² ³		Arylamine N-Acetyltransferase 2²
NAT-2² ³		Polymorphic Arylamine N-Acetyltransferase³
PNAT² ³

External Ids:	HGNC: 7646¹	Entrez Gene: 10²	Ensembl: ENSG00000156006⁷	OMIM: 612182⁵	UniProtKB: P11245³

Export aliases for NAT2 gene to outside databases

Previous GC identifers: GC08P018125 GC08P018311 GC08P018259 GC08P018293 GC08P016793

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAT2:

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and

carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations

segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated

with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near

this gene (NAT2). (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245

Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or

O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known

carcinogens

Gene Wiki entry for NAT2 (N-acetyltransferase 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NAT2 gene promoter:
PPAR-gamma1 p53 GR-alpha PPAR-gamma2 Zic3 GATA-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAT2 promoter sequence

Search SABiosciences Chromatin IP Primers for NAT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22

NAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P018250: view genomic region (about GC identifiers)

Start:	18,248,755 bp from pter	End:	18,258,728 bp from pter
Size:	9,974 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245 (See protein sequence)

Recommended Name: Arylamine N-acetyltransferase 2

Size: 290 amino acids; 33542 Da

Subcellular location: Cytoplasm

Sequence caution: Sequence=AAK51711.1; Type=Frameshift; Positions=287;

1 PDB 3D structure from and Proteopedia for NAT2:

2PFR (3D)

Secondary accessions: O43637 O60654 O60655 Q13146 Q16697 Q2MLE4 Q2MLF5 Q2MLG8 Q2MLJ6 Q2MLK4 Q2MLK6

Q2MLN7 Q6LET4 Q86XS0 Q86XS1 Q96KY8 Q96T64 Q96T65 Q9H220

Explore the universe of human proteins at neXtProt for NAT2: NX_P11245

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P11245

4/5 DME Specific Peptides for NAT2 (P11245) (see all 5)

SFCSLQT

AYFERIGY

WYLDQIRR

RGGWCLQVN

NAT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000006.2

ENSEMBL proteins:

ENSP00000286479 ENSP00000428416

Reactome Protein details: P11245
Human Recombinant Protein Products:

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	GenScript Custom Purified and Recombinant Proteins Services for NAT2
	Novus Biologicals NAT2 Proteins Novus Biologicals NAT2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NAT2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	--	--

NAT2 for ontologies About GeneDecksing

NAT2 Antibody Products:

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	Novus Biologicals NAT2 Antibodies
	Abcam antibodies for NAT2
	Uscn Antibodies for NAT2
	ThermoFisher Antibodies for NAT2

Assay Products for NAT2:

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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NAT2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NAT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NAT2 for domains About GeneDecksing

1 InterPro domain/family:

IPR001447 Arylamine_N-AcTrfase

Graphical View of Domain Structure for InterPro Entry P11245

ProtoNet protein and cluster: P11245

1 Blocks protein family: IPB004081 Arylamine N-acetyltransferase signature

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245

Similarity: Belongs to the arylamine N-acetyltransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245

Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or

O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known

carcinogens

Catalytic activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

Genatlas biochemistry entry for NAT2:

arylamine N-acetyltransferase 2,polymorphic,responsible for slow or rapid acetylation of arylamine and hydrazine

drugs,putative susceptibility factor in squamous-cell carcinoma of the esophagus,also involved in bladder

carcinogenesis and breast cancer

Enzyme Number (IUBMB): EC 2.3.1.5¹ ²

miRNA Products:		OriGene 3'-UTR Clone: NAT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NAT2
		SwitchGear 3'UTR luciferase reporter plasmid: NAT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT2 (see all 7) OriGene shRNA RFP: NAT2 OriGene siRNA: NAT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NAT2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NAT2 (NM_000015)
		Sino Biological Human cDNA Clone for NAT2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NAT2
		Search LifeMap BioReagents cell lines for NAT2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004060	arylamine N-acetyltransferase activity	IEA	--
GO:0015179	L-amino acid transmembrane transporter activity	--	--
GO:0016407	acetyltransferase activity	--	--

NAT2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NAT2:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Nat1/Nat2^Nat1/tm1Kss for NAT2
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nat1):

homeostasis/metabolism

reproductive system

NAT2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Acetaminophen Pathway, Pharmacokinetics

Pathway_PA165986194 -need delete

1.00

Acetaminophen Pathway, Pharmacokinetics

1.00

Caffeine Pathway, Pharmacokinetics

Caffeine Pathway, Pharmacokinetics

1.00

Caffeine metabolism

0.36

Acetylation

Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for NAT2

	Arylamine metabolism
	metapathway biotransformation

4 Reactome Pathways for NAT2

	Metabolism
	Biological oxidations
	Acetylation
	Phase II conjugation

5 PharmGKB Pathways for NAT2

	Acetaminophen Pathway, Pharmacokinetics
	Benzodiazepine Pathway, Pharmacokinetics
	Busulfan Pathway, Pharmacodynamics
	Caffeine Pathway, Pharmacokinetics
	Pathway_PA165986194 -need delete

3 Kegg Pathways (Kegg details for NAT2):

	Caffeine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways

NAT2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NAT2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for NAT2 (P11245³ ENSP00000286479⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NAA10	P41227³, ENSP00000417763⁴	I2D: score=1 STRING: ENSP00000417763
CYP1A2	ENSP00000342007⁴	STRING: ENSP00000342007
CYP2A13	ENSP00000332679⁴	STRING: ENSP00000332679
CYP2A6	ENSP00000301141⁴	STRING: ENSP00000301141
XDH	ENSP00000368727⁴	STRING: ENSP00000368727

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

NAT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NAT2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NAT2

7 HMDB Compounds for NAT2 About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Aminosalicylic acid	3-Amino Salicylate (see all 16)	570-23-0	--
5-Acetylamino-6-formylamino-3-methyluracil		--	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Aniline	Aminobenzene (see all 16)	62-53-3	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--
N-Acetylarylamine	N-Acetylarylamine	55576-55-1	--
Paraxanthine	1,7-Dimethylxanthine (see all 2)	611-59-6	--

3 DrugBank Compounds for NAT2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Dapsone	Acedapsone (see all 29)	80-08-0	enzyme	substrate	19515014
Isoniazid	HIA (see all 13)	54-85-3	enzyme	substrate	11703656
Sulfamethoxazole	--	723-46-6	enzyme	substrate	19515014

10/96 Novoseek chemical compound relationships for NAT2 gene (see all 96) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arylamine	96.8	249	1996083 (3), 8081359 (3), 2376572 (2), 7995004 (2) (see all 99)
afmu	93.2	39	10027663 (3), 11393735 (2), 12580991 (2), 1306111 (2) (see all 15)
1-methylxanthine	89.6	33	10027663 (3), 12580991 (2), 14747882 (1), 8573631 (1) (see all 14)
n-acetylsulfapyridine	86.8	6	12186410 (2), 15032315 (2)
1,7-dimethyluric acid	85.4	6	10027663 (1), 11393735 (1), 12580991 (1), 17221922 (1)
5-acetylamino-6-amino-3-methyluracil	85.3	11	14747882 (1), 8573631 (1), 11393735 (1), 11503005 (1) (see all 5)
2-aminofluorene	81.5	12	11337936 (1), 16829624 (1), 8179482 (1), 9571233 (1) (see all 8)
phip	81.1	46	19666988 (3), 15110095 (3), 19301197 (2), 11158715 (2) (see all 18)
n-hydroxy phip	80.7	5	12773763 (2), 12016157 (1)
n-hydroxy-2-aminofluorene	79.4	4	8425184 (2), 8353847 (1)

7 PharmGKB related drug/compound annotations for NAT2 gene

Drug/compound	PharmGKB Annotation
docetaxel	CA
hydralazine	DL
isoniazid	DL
isosorbide dinitrate	DL
pyrazinamide	DL
rifampin	DL
thalidomide	CA

About this table

Search CenterWatch for drugs/clinical trials and news about NAT2 / ARY2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NAT2 gene:

NM_000015.2

Unigene Cluster for NAT2:

N-acetyltransferase 2 (arylamine N-acetyltransferase)

Hs.2 [show with all ESTs]

Unigene Representative Sequence: BC067218

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000286479(uc003wyw.1) ENST00000520116

miRNA Products:		OriGene 3'-UTR Clone: NAT2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT2 (see all 7) OriGene shRNA RFP: NAT2 OriGene siRNA: NAT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NAT2 (NM_000015)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT2

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT2

Additional cDNA sequence:

AJ581144.1 AJ581145.1 AJ581146.1 AJ581147.1 BC015878.1 BC067218.1 CR407631.1 D90040.1

D90042.1

2 DOTS entries:

DT.312018 DT.121480210

24/27 AceView cDNA sequences (see all 27):

CB161982 AU099534 BC067218 BG618195 AI792606 D90040 BG617259 AI733799

BG563731 BC015878 BU624903 NM_000015 CB161860 BG569293 BV183942 D90042

AI460128 BV183943 CR407631 BG533459 BG566307 BG568400 BV183945 AI262683

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NAT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAGAAAACA

About this image
See NAT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAT2

SOURCE GeneReport for Unigene cluster: Hs.2

SABiosciences Expression via Pathway-Focused PCR Arrays including NAT2:

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NAT2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NAT2 gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nat1^{1 , 5}	N-acetyl transferase 1^{1, 5}	78.51(n)¹ 71.72(a)¹		8 (33.38 cM)⁵ 17960¹ NM_008673.1¹ NP_032699.1¹ 67490758⁵
chicken (Gallus gallus)	Aves	F1P5U3_CHICK⁶ E1C5Y2_CHICK⁶ (see all 4)	Uncharacterized protein (see all 4)	56(a) 51(a) (see all 4)	many ↔ many many ↔ many (see all 4)	11(17503003-17507517) 11(17483758-17484630)
lizard (Anolis carolinensis)	Reptilia	--	--	53(a)	1 → many	GL343663.1(8584-9450)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-78a14.4⁶ zgc:101040⁶ (see all 7)	zgc:101040 (see all 7)	40(a) 39(a) (see all 7)	many ↔ many many ↔ many (see all 7)	7(39641960-39649371) 18(38776775-38781242)
E. coli (Escherichia coli)	Gamma proteobacteria	nhoA⁶	N-hydroxyarylamine O-acetyltransferase	21(a)	1 → many	Chromosome(1532048-1532893)

ENSEMBL Gene Tree for NAT2 (if available)
TreeFam Gene Tree for NAT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NAT2 gene

NAT1²

1 SIMAP similar gene for NAT2 using alignment to 31 protein entries: ARY2_HUMAN (see all proteins):

NAT1

NAT2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NAT2
PGOHUM00000256796

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245

Polymorphism: Polymorphisms in NAT2 are the cause of slow and fast acetylation phenotypes [MIM:243400] and influence

drug therapy response and susceptibility to chemical toxicity or carcinogenicity

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1208^1,2	C,F,A,H,	drug-response	18258316(+)	`GCTGAA/GAAATA`	2	K R	mis¹ ese³		51		EA MN NA CSAM NS WA EU	10981
rs1799931^1,2	C,F,H,	drug-response	23530955(+)	`TGATGG/AATCCC`	2	/E /G	mis¹ ese³		41		MN NA NS EA CSAM WA EU	10279
rs1799930^1,2	C,F,O,H,	drug-response	23531222(+)	`ACCTCA/GAACAA`	2	Q R	mis¹ ese³		51		MN EA NA CSAM NS WA PA EU	11501
rs1801280^1,2	C,F,H,	drug-response	23531471(+)	`GACCAT/CTGACG`	2	/T /I	mis¹ ese³		39		MN NA CSAM NS EA WA EU	9744
rs56308158^1,2	C,	--	16791155(+)	`CTCTTC/TGCCTG`	1	--	us2k¹		0	--	--	--	--
rs56107563^1,2	C,	--	16791158(+)	`TTCGCC/TTGTGT`	1	--	us2k¹		0	--	--	--	--
rs72500136^1,2	C,	--	16791976(+)	`TCCCAC/GAGAGT`	1	--	us2k¹		0	--	--	--	--
rs56293428^1,2	C,	--	16792703(+)	`TGACTA/GAAACC`	1	--	us2k¹		0	--	--	--	--
rs45625631^1,2	C,F,	--	16792864(+)	`TAGCCT/CGTGGC`	1	--	us2k¹		1		NS	178
rs55927170^1,2	C,	--	16792924(+)	`ATTTGC/TGTAAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NAT2 (18248755 - 18258728 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAT2: --
Human Gene Mutation Database (HGMD): NAT2

Locus Specific Mutation Databases (LSDB): NAT2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT2

DNA2.0 Custom Variant and Variant Library Synthesis for NAT2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NAT2 for disorders           About GeneDecksing

OMIM gene information: 612182
OMIM disorders: 243400
20/135 diseases for NAT2 (see all 135):    About MalaCards

acetylation, slow drug-induced hepatitis familial adenomatous polyposis neural tube defect

laryngeal squamous cell carcinoma multiple chemical sensitivity allergic contact dermatitis contact dermatitis

growth hormone deficiency mutagen sensitivity malignant pleural mesothelioma non-hodgkin lymphoma

food allergy lupus erythematosus gilbert syndrome inflammatory bowel disease

2 diseases from the University of Copenhagen DISEASES database for NAT2:

Urinary bladder cancer Tuberculosis

10/93 Novoseek disease relationships for NAT2 gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bladder cancer	74.9	184	10510890 (8), 15312364 (6), 10917561 (5), 9107426 (5) (see all 65)
genetic susceptibility	63.5	19	12015038 (2), 12474054 (2), 10698723 (1), 11751440 (1) (see all 12)
colorectal cancer	58.6	104	17525862 (7), 16434594 (6), 18159984 (6), 9301503 (4) (see all 41)
cancer	56.6	157	15548945 (5), 10667461 (5), 12351146 (4), 9301503 (4) (see all 86)
hepatitis toxic	55	3	20392357 (1), 19891553 (1)
cancer lung	42.6	85	11815396 (5), 17477782 (5), 18706736 (5), 9731715 (4) (see all 27)
colon cancer	41	27	9301503 (3), 9865425 (3), 16827944 (3), 11099063 (2) (see all 12)
breast cancer	39.1	148	17535831 (6), 11008907 (6), 12708724 (5), 15609332 (5) (see all 41)
chromosomal aberrations	35.3	15	10207633 (5), 10333536 (1), 10517994 (1), 15055296 (1) (see all 8)
lupus erythematosus	32.9	4	12611196 (1), 10599336 (1), 9321764 (1)

Genatlas disease: NAT2

isoniazid inactivation

Genetic Association Database (GAD): NAT2
Human Genome Epidemiology (HuGE) Navigator: NAT2 (470 documents)

Export disorders for NAT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NAT2 gene, integrated from 9 sources (see all 1008):
(articles sorted by number of sources associating them with NAT2)

Utopia: connect your pdf to the dynamic
world of online information

[Relationship between genetic polymorphism of NAT2 and susceptibility to urinary bladder cancer] (PubMed id 15312364)^{1, 4, 9} Hao G.Y....Zhang Y.H. (2004)
Differential interactions between GSTM1 and NAT2 genotypes on aromatic DNA adduct level and HPRT mutant frequency in lung cancer patients and population controls. (PubMed id 11219770)^{1, 4, 9} Hou S.M....Lambert B. (2001)
'Comparison of extremes' approach provides evidence against the modifying role of NAT2 polymorphism in lung cancer susceptibility. (PubMed id 15808403)^{1, 4, 9} Belogubova E.V....Imyanitov E.N. (2005)
Cytochrome P450 (CYP) 1A2, sulfotransferase (SULT) 1A1, and N-acetyltransferase (NAT) 2 polymorphisms and susceptibility to urothelial cancer. (PubMed id 14648207)^{1, 4, 9} Tsukino H....Katoh T. (2004)
Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China? (PubMed id 15770721)^{1, 4, 9} Zhang X.F....Tang B.M. (2005)
NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. (PubMed id 16112301)^{1, 4, 9} Garcia-Closas M....Rothman N. (2005)
Combined effects of well-done red meat, smoking, and rapid N-acetyltransferase 2 and CYP1A2 phenotypes in increasing colorectal cancer risk. (PubMed id 11751443)^{1, 4, 9} Le Marchand L....Donlon T. (2001)
Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. (PubMed id 11245417)^{1, 4, 9} Frazier M.L....Amos C.I. (2001)
Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in Caucasians. (PubMed id 15725609)^{1, 4, 9} Gu J....Wu X. (2005)
[Relationship between polymorphism of N-acetyltransferase 2 and genetic susceptibility to laryngeal carcinoma] (PubMed id 12015038)^{1, 4, 9} Lei D....Luan X. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10	HGNC: 7646	AceView: NAT2	Ensembl:ENSG00000156006	euGenes: HUgn10
ECgene: NAT2	Kegg: 10	H-InvDB: NAT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NAT2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NAT2	Genetics and Cytogenetics in Oncology and Haematology
NAT	http://www.louisville.edu/medschool/pharmacology/NAT.html
NIEHS-SNPs	http://egp.gs.washington.edu/data/nat2/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT2

Intellectual Property for NAT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NAT2 gene:
Search GeneIP for patents involving NAT2

GeneCards and IP:
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N-acetyltransferase 2 (arylamine N-acetyltransferase)

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NAT2 Gene

N-acetyltransferase 2 (arylamine N-acetyltransferase)

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