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NAT2 Gene

protein-coding   GIFtS: 63

GC08P018293
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AAC2)
Services    

Aliases &
Descriptions
for NAT2

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
AAC2 2, 3, 5
EC 2.3.1.5 3
NAT-2 3
PNAT 2, 3
Descriptions
Arylamide acetylase 2 2, 3
N-acetyltransferase 2 2
N-acetyltransferase 2 (arylamine N-acetyltransferase) 2
N-acetyltransferase type 2 3
Polymorphic arylamine N-acetyltransferase 3
External Ids
HGNC: 76461
Entrez Gene: 102
UniProtKB: P112453
Ensembl: ENSG000001560067
Search outside databases for aliases for NAT2 gene

Previous GC identifers: GC08P018125 GC08P018311 GC08P018259

Summaries
for NAT2

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for NAT2:
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine
drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation
polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator
phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and
drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene
(NAT2). [provided by RefSeq]

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245
Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is
able to bioactivate several known carcinogens

Gene Wiki entry for NAT2 (N-acetyltransferase_2)

Genomic Location
for NAT2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NAT2 gene  

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

NAT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P018293:     (about GC identifiers)

Start:
 18,293,035 bp from pter
End:
 18,303,003 bp from pter
Size:
 9,969 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000008.9  NT_030737.9  

Proteins
for NAT2

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245 (See protein sequence)
Recommended Name: Arylamine N-acetyltransferase 2  
Size: 290 amino acids; 33542 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
2PFR (3D)    
Secondary accessions: O43637 O60654 O60655 Q13146 Q16697 Q2MLE4 Q2MLF5 Q2MLG8 Q2MLJ6 Q2MLK4 Q2MLK6
Q2MLN7 Q6LET4 Q86XS0 Q86XS1 Q96KY8 Q96T64 Q96T65 Q9H220

REFSEQ proteins: NP_000006.2  

ENSEMBL proteins: 
ENSP00000286479 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Sigma-Aldrich Proteins for NAT2  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (NAT2)
Human Recombinant Proteins from Abnova (NAT2)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
GO:0005829 cytosol EXP1559981
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Antibodies for NAT2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for NAT2
Browse R&D Systems for Antibodies
Antibodies from Abcam (NAT2), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (NAT2)
Novus Biologicals Antibodies for NAT2

Assays for NAT2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for NAT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR001447 N-AcTrfase


   GeneDecks  NAT2 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P11245

ProtoNet protein and cluster: P11245

1 Blocks protein family: IPB004081 Arylamine N-acetyltransferase signature

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245
Similarity: Belongs to the arylamine N-acetyltransferase family

Gene Function
for NAT2

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (NAT2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NAT2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000015

              Applied Biosystems Silencer® siRNAs for NAT2

              Sigma-Aldrich siRNA for NAT2  
                     Sigma-Aldrich shRNA for NAT2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for NAT2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000015
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000015
                                 untagged cDNA clone in CMV expression vector: NM_000015 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000015

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245
Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs.
Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is
able to bioactivate several known carcinogens
Catalytic activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
Enzyme Number (IUBMB): EC 2.3.1.5 

Genatlas biochemistry entry for NAT2:
arylamine N-acetyltransferase 2,polymorphic,responsible for slow or rapid acetylation of arylamine
and hydrazine drugs,putative susceptibility factor in squamous-cell carcinoma of the
esophagus,also involved in bladder carcinogenesis and breast cancer

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nat1):

homeostasis/metabolismreproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004060 arylamine N-acetyltransferase activity TAS2340091
GO:0016407 acetyltransferase activity IEA--
GO:0016740 transferase activity IEA--
About this table

Pathways & Interactions
for NAT2

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


2 Kegg Pathways  (Kegg details for NAT2):
 hsa00232 Caffeine metabolism
 hsa00983 Drug metabolism - other enzymes

   GeneDecks  NAT2 for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  NAT2 


5/9 Interacting proteins for NAT2 (ENSP000002864793) via UniProtKB, MINT, and/or STRING (see all 9 )
InteractantInteraction Details
GeneCardExternal ID(s)
CYP1A2ENSP000003420073STRING (score=.947)
CYP2A6ENSP000003011413STRING (score=.925)
CYP2A13ENSP000003326793STRING (score=.899)
XRCC3ENSP000003433923STRING (score=.885)
GSTM1ENSP000003588383STRING (score=.726)
About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0008152 metabolic process IEA--
About this table

Drugs & Compounds
for NAT2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT2
10/56 Novoseek chemical compound relationships for NAT2 gene (see all 56 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
arylamine 96.79 233 1996083 (3), 8081359 (3), 2376572 (2), 7995004 (2) (see all 99)
afmu 92.41 39 10027663 (3), 11393735 (2), 12580991 (2), 1306111 (2) (see all 15)
1-methylxanthine 88.43 33 10027663 (3), 12580991 (2), 14747882 (1), 8573631 (1) (see all 14)
1,7-dimethyluric acid 85.80 6 10027663 (1), 11393735 (1), 12580991 (1), 17221922 (1)
5-acetylamino-6-amino-3-methyluracil 85.26 11 14747882 (1), 8573631 (1), 11393735 (1), 11503005 (1) (see all 5)
n-acetylsulfapyridine 82.53 6 12186410 (2), 15032315 (2)
2-aminofluorene 81.40 12 11337936 (1), 16829624 (1), 8179482 (1), 9571233 (1) (see all 8)
n-hydroxy-2-aminofluorene 79.90 4 8425184 (2), 8353847 (1)
n-hydroxy phip 79.89 5 12773763 (2), 12016157 (1)
phip 79.54 41 15110095 (3), 11158715 (2), 10381774 (2), 7697826 (2) (see all 16)
About this table

10/10 PharmGKB drug compound relationships for NAT2 gene (see all 10 )
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
caffeinePK  GN  11773863 8888070
dextromethorphanPK  8888070
hydralazinePD  PK  6519160
interferon alphaPK  12087352
isoniazidPK  9202739
procainamidePK  GN  9164413
ribavirinPK  12087352
sulfamethazineFA  GN  15564878
sulfamethoxazolePK  9131488
xenobioticsCO  FA  GN  1675794 11773864 12235453
About this table


Transcripts
for NAT2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (NAT2)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (NAT2)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000015

              Sigma-Aldrich siRNA for NAT2  
                     Sigma-Aldrich shRNA for NAT2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000015  

REFSEQ mRNAs for NAT2 gene: 

NM_000015.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000015  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000015
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000015
                                 untagged cDNA clone in CMV expression vector: NM_000015 

Additional cDNA sequence: 

AJ581144.1 AJ581145.1 AJ581146.1 AJ581147.1 BC015878.1 BC067218.1 CR407631.1 D90040.1 
D90042.1 

2 DOTS entries:

DT.312018  DT.121480210 

24/27 AceView cDNA sequences (see all 27 ):

CB161982 AU099534 BC067218 CR407631 AI792606 AI733799 D90042 BG618195 
CB161860 NM_000015 BV183942 BG617259 D90040 BC015878 BU624903 AI460128 
BV183943 BG563731 BG569293 BV183945 BG568400 BG566307 BG533459 AI262683 

highest scoring ESTs for NAT2:

AI262683 AI460128 AI733799 AI792606 AU099534 AV658623 AV658656 AV684197 BC015878 BC067218 

Unigene Cluster for NAT2:

N-acetyltransferase 2 (arylamine N-acetyltransferase)
Hs.2  [show with all ESTs]
Unigene Representative Sequence: BC067218


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000286479  

Expression
for NAT2

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for NAT2

1 / 2 / 3

3 probe-sets matching NAT2 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
38912_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 U53473 0.20 1.00 0.72 1

206797_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000015 0.60 1.00 0.82 1

206797_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  NAT2 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTAGAAAACA

SOURCE GeneReport for Unigene cluster: Hs.2

Orthologs
for NAT2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for NAT2 gene from 3 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 NAT21   -- N-acetyltransferase 2 (arylamine N-acetyltransferase) 98.51(n)
96.55(a)		 464024  XM_001146758.1  XP_001146758.1 
rat
(Rattus norvegicus)		 Nat11   -- N-acetyltransferase 1 (arylamine N-acetyltransferase) 79.08(n)
74.14(a)		 116631  NM_001037315.1  NP_001032392.1 
mouse
(Mus musculus)		 Nat11, 5 8 (31.00 cM)5
 N-acetyltransferase 1 (arylamine N-acetyltransferase)1, 5 78.51(n)1
71.72(a)1		 179601  NM_008673.11  NP_032699.11 
 AJ2501235  AJ3146505  (see all 14)
About this table        Species with no ortholog for NAT2

ENSEMBL Gene Tree for NAT2

Paralogs
for NAT2

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for NAT2 gene
NAT12  

SNPs/Variants
for NAT2

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/144 NCBI SNPs in NAT2 are shown (see all 144 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 122)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 8 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs42710021,2
A,C,F,H18292548(+) CATGTG/CACACT 1 -- ng518Minor allele frequency- C:0.14EU EA WA NA NS 726
--
rs46462421,2
A,C,F,H18291729(+) ggagtA/GTAACA 1 -- ng518Minor allele frequency- G:0.24EU EA WA 838
rs43456001,2
A,C,F,H18292488(+) GAGAAA/GTAAAA 1 -- ng51 tfbs35Minor allele frequency- G:0.04EU EA WA NS 564
rs17999301,2
C,F,H,O18302383(+) ACCTCA/GAACAA 1 R/Q mis1 ese328Minor allele frequency- N:0.00MN CSAM EA NA EU WA NS 2778
rs12081,2
A,C,F,H18302596(+) GCTGAA/GAAATA 1 R/K mis1 ese328Minor allele frequency- G:0.30EA MN CSAM EU WA NA NS 2728
rs127200651,2
C,F,H18302196(+) AGCCTC/GTAGAA 1 L/V mis1 ese38Minor allele frequency- G:0.00EU EA WA 804
rs43456011,2
A,C,F18292493(+) ATAAAA/TATTTA 1 -- ng51 tfbs31Minor allele frequency- T:0.11NS 168
rs46462471,2
C,F,H18303188(+) CACAAG/AAGAAG 1 -- ng3118Minor allele frequency- A:0.24NA EU EA WA NS 1606
rs46462431,2
C,F,H18291889(+) ATATTT/CAGTCT 1 -- ng519Minor allele frequency- C:0.31EA NS 826
rs18012801,2
C,F,H18302134(+) GACCAT/CTGACG 1 T/I mis1 ese326Minor allele frequency- C:0.28MN CSAM EA NA EU WA NS 2574
About this table

HapMap Linkage Disequilibrium images for NAT2 (up to first 250kb)

Disorders & Mutations
for NAT2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 612182   disorders: 243400  

UniProtKB/Swiss-Prot: ARY2_HUMAN, P11245

  • Genetic variations in NAT2 determine N-acetylation polymorphism by a low or high NAT
    activity in the liver [MIM:243400]. It has been implicated in the action and toxicity of
    amine-containing drugs, and in the susceptibility to bladder cancer and systemic lupus
    erythematosus. This isozyme is responsible for this polymorphism

    • 10/93 Novoseek disease relationships for NAT2 gene (see all 93 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 75.13 173 10510890 (8), 15312364 (6), 10917561 (5), 9107426 (5) (see all 61)
    genetic susceptibility 61.05 19 12015038 (2), 12474054 (2), 10698723 (1), 11751440 (1) (see all 12)
    colorectal cancer 60.28 98 17525862 (7), 16434594 (6), 18159984 (6), 9301503 (4) (see all 40)
    cancer 57.14 150 15548945 (5), 10667461 (5), 12351146 (4), 9301503 (4) (see all 82)
    cancer lung 43.39 80 11815396 (5), 17477782 (5), 18706736 (5), 9731715 (4) (see all 25)
    colon cancer 42.19 27 9301503 (3), 9865425 (3), 16827944 (3), 11099063 (2) (see all 12)
    breast cancer 39.35 135 17535831 (6), 11008907 (6), 12708724 (5), 15609332 (5) (see all 38)
    chromosomal aberrations 35.58 14 10207633 (5), 10333536 (1), 10517994 (1), 11535252 (1) (see all 7)
    lupus erythematosus 34.77 4 12611196 (1), 10599336 (1), 9321764 (1)
    smoking habit 32.00 1 15609332 (1)
    About this table

    6 PharmGKB disease relationships for NAT2 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Arthritis, RheumatoidGN  12235453
    CataractCO  GN  12724621
    Colorectal NeoplasmsCO  11773864
    Cystic FibrosisPK  8888070
    Hepatitis C, ChronicPK  12087352
    TuberculosisPK  9202739
    About this table

    Genatlas disease: NAT2
    isoniazid inactivation

    Human Gene Mutation Database: NAT2
    Genetic Association Database: NAT2
    Human Genome Epidemiology Navigator: NAT2 (359 documents)

    Medical News
    for NAT2

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for NAT2

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/822 PubMed articles for NAT2 gene (see all 822 ):

    Search for NAT2

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NAT2

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 10 HGNC: 7646 AceView: NAT2 Ensembl:ENSG00000156006 euGenes: HUgn10
    ECgene: NAT2 H-InvDB: NAT2

    Other Databases showing NAT2

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing NAT2

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for NAT2 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nat2/

    Licensable Technologies
    for NAT2

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for NAT2

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NAT2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NAT2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NAT2 Antibodies for NAT2
     Explore super-pooled esiRNAs Proteins for NAT2
     Lentivirus-delivered shRNAs for NAT2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search OriGene for NAT2
     Search Tocris compounds for NAT2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NAT2

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