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NAT16 Gene

protein-coding   GIFtS: 34
GCID: GC07M100814

N-Acetyltransferase 16 (GCN5-Related, Putative)

(Previous name: chromosome 7 open reading frame 52)
(Previous symbol: C7orf52)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetyltransferase 16 (GCN5-Related, Putative)1 2
C7orf521 2 3
Chromosome 7 Open Reading Frame 521
Putative N-Acetyltransferase 162
Putative N-Acetyltransferase C7orf522
EC 2.3.1.-3

External Ids:    HGNC: 220301   Entrez Gene: 3756072   Ensembl: ENSG000001670117   UniProtKB: Q8N8M03   

Export aliases for NAT16 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NAT16 Gene:
NAT16 (N-acetyltransferase 16 (GCN5-related, putative)) is a protein-coding gene. GO annotations related to this gene include N-acetyltransferase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NC_018918.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NAT16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NAT16 promoter sequence
   Search Chromatin IP Primers for NAT16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAT16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

NAT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT16 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100814:  view genomic region     (about GC identifiers)

Start:
100,813,774 bp from pter      End:
100,823,557 bp from pter
Size:
9,784 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,172,161-100,181,944     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NAT16_HUMAN, Q8N8M0 (See protein sequence)
Recommended Name: Putative N-acetyltransferase 16  
Size: 369 amino acids; 40521 Da
Secondary accessions: Q8NDR1

Explore the universe of human proteins at neXtProt for NAT16: NX_Q8N8M0

Explore proteomics data for NAT16 at MOPED


See NAT16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_940973.2  
ENSEMBL proteins: 
 ENSP00000300303   ENSP00000395125   ENSP00000391769   ENSP00000394435  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000182 GNAT_dom
 IPR016181 Acyl_CoA_acyltransferase

Graphical View of Domain Structure for InterPro Entry Q8N8M0

ProtoNet protein and cluster: Q8N8M0

UniProtKB/Swiss-Prot: NAT16_HUMAN, Q8N8M0
Similarity: Contains 1 N-acetyltransferase domain


Find genes that share domains with NAT16           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Enzyme Number (IUBMB): EC 2.3.1.-1

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008080N-acetyltransferase activity IEA--
     
Find genes that share ontologies with NAT16           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NAT16

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAT16
Interactions:

    Search GeneGlobe Interaction Network for NAT16

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for NAT16 (ENSP000003003034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
NOD2ENSP000003005894STRING: ENSP00000300589
RIPK2ENSP000002207514STRING: ENSP00000220751
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for NAT16



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for NAT16 gene: 
NM_198571.2  

Unigene Cluster for NAT16:

N-acetyltransferase 16 (GCN5-related, putative)
Hs.213044  [show with all ESTs]
Unigene Representative Sequence: NM_198571
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000300303(uc003uxy.2 uc003uxz.2) ENST00000455377 ENST00000444446
ENST00000443096(uc003uya.1 uc003uyb.1)
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Additional mRNA sequence: 

AK092119.1 AK096556.1 AL831911.1 BC037583.1 BC104841.1 

5 DOTS entries:

DT.65288621  DT.100018599  DT.97834535  DT.95355329  DT.121126563 

20 AceView cDNA sequences:

BQ640011 AI914085 AK096556 BX119484 BM727073 AL831911 BC037583 BG327091 
AI912271 NM_198571 AX747364 BE218557 AK092119 BV185387 BI916227 BF346450 
H83792 BE549627 BM726057 H83934 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NAT16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGAGACCCCT
NAT16 Expression
About this image

NAT16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NAT16 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.213044
    Custom PCR Arrays for NAT16
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NAT16 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia NAT161 N-acetyltransferase 16 (GCN5-related, putative) 79.78(n)
72.53(a)
  100684972  XM_003434743.2  XP_003434791.1 
African clawed frog
(Xenopus laevis)
Amphibia BQ736518.12   -- 73.45(n)    BQ736518.1 
zebrafish
(Danio rerio)
Actinopterygii LOC1000032451 putative N-acetyltransferase 16-like 59.4(n)
55.45(a)
  100003245  XM_001342820.2  XP_001342856.1 


ENSEMBL Gene Tree for NAT16 (if available)
TreeFam Gene Tree for NAT16 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NAT16 (see all 296)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs737138031,2
C--100813278(+) CCAATC/ACAGAG 1 -- int13Minor allele frequency- A:0.17WA EA 240
rs680442651,2
C,F--100813287(+) AGCAGG/CCTTCG 1 -- int16Minor allele frequency- C:0.09NA WA CSA EA 364
rs1855824531,2
--100813661(+) GGGAAC/GTCATT 1 -- int10--------
rs1906421511,2
--100813722(+) GAAAGA/GGGAAG 1 -- int10--------
rs22861191,2
C,F,H--100813831(+) GGAGGG/ATGGCA 1 -- ut314Minor allele frequency- A:0.01EA NS NA 172
rs1392372191,2
--100813994(+) TCCCAA/GCGAAC 1 -- ut310--------
rs10065071,2
C,F,A,H--100814034(+) ACCTAC/TGCATT 1 -- ut31 ese329Minor allele frequency- T:0.48NA EA MN NS WA 4632
rs18595281,2
C,F,O,A,H--100814078(+) CAGAGT/CGAAGT 1 -- ut31 ese326Minor allele frequency- C:0.44MN NS EA NA WA 2890
rs1166924231,2
C,F--100814389(+) GGAGAC/TAGCCC 1 -- ut311Minor allele frequency- T:0.05WA 118
rs119754901,2
C,H--100814444(+) CAGCTA/GGAACC 1 -- ut31 ese30--------

HapMap Linkage Disequilibrium report for NAT16 (100813774 - 100823557 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NAT16: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NAT16
DNA2.0 Custom Variant and Variant Library Synthesis for NAT16

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NAT16 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NAT16)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for NI+-acetylhistidine synthesis. (PubMed id 24121108)1 Yamada S. and Arikawa S. (Biochim. Biophys. Acta 2014)
  3. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. (PubMed id 22607974)1 Damgaard R.B....Gyrd-Hansen M. (Mol. Cell 2012)
  4. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 375607 HGNC: 22030 AceView: FLJ39237 Ensembl:ENSG00000167011 euGenes: HUgn375607
ECgene: NAT16 H-InvDB: NAT16

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NAT16 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NAT16 gene:
Search GeneIP for patents involving NAT16

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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