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Aliases for NAT16 Gene

Aliases for NAT16 Gene

  • N-Acetyltransferase 16 (Putative) 2 3 5
  • N-Acetyltransferase 16 (GCN5-Related, Putative) 2 3
  • C7orf52 3 4
  • Putative N-Acetyltransferase C7orf52 3
  • Chromosome 7 Open Reading Frame 52 2
  • Probable N-Acetyltransferase 16 3
  • Putative N-Acetyltransferase 16 3
  • EC 2.3.1.- 4

External Ids for NAT16 Gene

Previous HGNC Symbols for NAT16 Gene

  • C7orf52

Previous GeneCards Identifiers for NAT16 Gene

  • GC07M100814

Summaries for NAT16 Gene

GeneCards Summary for NAT16 Gene

NAT16 (N-Acetyltransferase 16 (Putative)) is a Protein Coding gene. GO annotations related to this gene include N-acetyltransferase activity and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT16 Gene

  • Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT16 Gene

Genomics for NAT16 Gene

Regulatory Elements for NAT16 Gene

Enhancers for NAT16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G101165 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.7 +29.4 29382 2.7 PKNOX1 MLX AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF766 AP1S1 NAT16 MOSPD3 TSC22D4 VGF MIR4653
GH07G101159 1.6 Ensembl ENCODE dbSUPER 21.8 +33.8 33815 5.5 HDGF PKNOX1 ARNT AGO1 SIN3A ARID4B YBX1 ZNF766 ZNF143 FOS AP1S1 NYAP1 NAT16 GIGYF1 PPP1R35 FIS1 STAG3L5P AZGP1P2 LNCPRESS1 EPHB4
GH07G101153 1.3 ENCODE dbSUPER 21.9 +40.1 40134 3.9 HDGF PKNOX1 AGO1 SIN3A ARID4B DMAP1 ZNF2 YY1 ZNF143 ZNF207 AP1S1 NAT16 GIGYF1 STAG3L5P SERPINE1 FIS1 AZGP1P2 LNCPRESS1 PPP1R35 MIR4653
GH07G101173 1.3 ENCODE dbSUPER 20.9 +22.1 22144 1.8 HDGF ATF1 AGO1 ARID4B ZNF121 GLIS2 ZNF416 KLF7 SP3 SMARCB1 NAT16 AP1S1 PILRB VGF
GH07G101098 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +93.9 93887 6.4 MLX CREB3L1 DMAP1 YY1 SLC30A9 MEF2D SSRP1 GLIS1 RCOR2 NBN SERPINE1 VGF NAT16 MUC12 MBLAC1 MUC3A MUC17 TRIM56 PCOLCE-AS1 LOC102724094
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAT16 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAT16 Gene

Chromosome:
7
Start:
101,170,493 bp from pter
End:
101,195,908 bp from pter
Size:
25,416 bases
Orientation:
Minus strand

Genomic View for NAT16 Gene

Genes around NAT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT16 Gene

Proteins for NAT16 Gene

  • Protein details for NAT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8M0-NAT16_HUMAN
    Recommended name:
    Probable N-acetyltransferase 16
    Protein Accession:
    Q8N8M0
    Secondary Accessions:
    • B3KRS2
    • Q8NDR1

    Protein attributes for NAT16 Gene

    Size:
    369 amino acids
    Molecular mass:
    40521 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • NAT16 is the ortholog of the ectothermic vertebrates enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl-histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace enzyme activity for NAH synthesis.

    Alternative splice isoforms for NAT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT16 Gene

Post-translational modifications for NAT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT16 Gene

No data available for DME Specific Peptides for NAT16 Gene

Domains & Families for NAT16 Gene

Gene Families for NAT16 Gene

Protein Domains for NAT16 Gene

Suggested Antigen Peptide Sequences for NAT16 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NAT16: view

No data available for UniProtKB/Swiss-Prot for NAT16 Gene

Function for NAT16 Gene

Molecular function for NAT16 Gene

UniProtKB/Swiss-Prot Function:
Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

Enzyme Numbers (IUBMB) for NAT16 Gene

Gene Ontology (GO) - Molecular Function for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IBA --
genes like me logo Genes that share ontologies with NAT16: view

Phenotypes for NAT16 Gene

genes like me logo Genes that share phenotypes with NAT16: view

Animal Model Products

CRISPR Products

miRNA for NAT16 Gene

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT16 Gene

Localization for NAT16 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT16 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NAT16 Gene

Pathways & Interactions for NAT16 Gene

SuperPathways for NAT16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006473 protein acetylation IBA --
genes like me logo Genes that share ontologies with NAT16: view

No data available for Pathways by source and SIGNOR curated interactions for NAT16 Gene

Drugs & Compounds for NAT16 Gene

No Compound Related Data Available

Transcripts for NAT16 Gene

Unigene Clusters for NAT16 Gene

N-acetyltransferase 16 (GCN5-related, putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT16 Gene

No ASD Table

Relevant External Links for NAT16 Gene

GeneLoc Exon Structure for
NAT16
ECgene alternative splicing isoforms for
NAT16

Expression for NAT16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT16 Gene

mRNA differential expression in normal tissues according to GTEx for NAT16 Gene

This gene is overexpressed in Pituitary (x11.0), Brain - Nucleus accumbens (basal ganglia) (x8.1), and Brain - Hypothalamus (x6.6).

NURSA nuclear receptor signaling pathways regulating expression of NAT16 Gene:

NAT16

SOURCE GeneReport for Unigene cluster for NAT16 Gene:

Hs.213044

Evidence on tissue expression from TISSUES for NAT16 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NAT16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT16 Gene

Orthologs for NAT16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT16 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia NAT16 34
  • 79.78 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nat16 34
  • 59.75 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100003245 34
  • 59.4 (n)
NAT16 35
  • 53 (a)
OneToOne
Species where no ortholog for NAT16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT16 Gene

ENSEMBL:
Gene Tree for NAT16 (if available)
TreeFam:
Gene Tree for NAT16 (if available)

Paralogs for NAT16 Gene

No data available for Paralogs for NAT16 Gene

Variants for NAT16 Gene

Sequence variations from dbSNP and Humsavar for NAT16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000275390 -- 101,174,055(+) TCCAG(C/T)TCCGA intron-variant
rs1000853888 -- 101,173,895(+) CTTTT(C/T)ATTTA intron-variant
rs1000978974 -- 101,179,537(+) TTGGA(A/G)ACAGA intron-variant, upstream-variant-2KB
rs1001031284 -- 101,179,845(+) GAGGG(A/G)GGCGG intron-variant, upstream-variant-2KB
rs1001162583 -- 101,177,969(+) TGTTC(A/G/T)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAT16 Gene

Variant ID Type Subtype PubMed ID
dgv11534n54 CNV loss 21841781
esv2422376 CNV duplication 17116639
esv2734888 CNV deletion 23290073
esv2752134 CNV gain 17911159
nsv1018841 CNV gain 25217958
nsv1030604 CNV gain 25217958
nsv607973 CNV loss 21841781
nsv607974 CNV loss 21841781
nsv831075 CNV loss 17160897

Variation tolerance for NAT16 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT16 Gene

Disorders for NAT16 Gene

Relevant External Links for NAT16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT16

No disorders were found for NAT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT16 Gene

Publications for NAT16 Gene

  1. An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for NI+-acetylhistidine synthesis. (PMID: 24121108) Yamada S. … Arikawa S. (Biochim. Biophys. Acta 2014) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. (PMID: 22607974) Damgaard R.B. … Gyrd-Hansen M. (Mol. Cell 2012) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for NAT16 Gene

Sources for NAT16 Gene

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