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Aliases for NAT16 Gene

Aliases for NAT16 Gene

  • N-Acetyltransferase 16 (GCN5-Related, Putative) 2 3
  • C7orf52 3 4
  • Putative N-Acetyltransferase C7orf52 3
  • Chromosome 7 Open Reading Frame 52 2
  • Probable N-Acetyltransferase 16 3
  • Putative N-Acetyltransferase 16 3
  • EC 2.3.1.- 4

External Ids for NAT16 Gene

Previous HGNC Symbols for NAT16 Gene

  • C7orf52

Previous GeneCards Identifiers for NAT16 Gene

  • GC07M100814

Summaries for NAT16 Gene

GeneCards Summary for NAT16 Gene

NAT16 (N-Acetyltransferase 16 (GCN5-Related, Putative)) is a Protein Coding gene. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT16 Gene

  • Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT16 Gene

Genomics for NAT16 Gene

Genomic Location for NAT16 Gene

Start:
101,170,493 bp from pter
End:
101,180,276 bp from pter
Size:
9,784 bases
Orientation:
Minus strand

Genomic View for NAT16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT16 Gene

No data available for Regulatory Elements for NAT16 Gene

Proteins for NAT16 Gene

  • Protein details for NAT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8M0-NAT16_HUMAN
    Recommended name:
    Probable N-acetyltransferase 16
    Protein Accession:
    Q8N8M0
    Secondary Accessions:
    • B3KRS2
    • Q8NDR1

    Protein attributes for NAT16 Gene

    Size:
    369 amino acids
    Molecular mass:
    40521 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • NAT16 is the ortholog of the ectothermic vertebrates enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl-histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace enzyme activity for NAH synthesis.

    Alternative splice isoforms for NAT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT16 Gene

Proteomics data for NAT16 Gene at MOPED

Post-translational modifications for NAT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT16 Gene

No data available for DME Specific Peptides for NAT16 Gene

Domains for NAT16 Gene

Protein Domains for NAT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8M0

UniProtKB/Swiss-Prot:

NAT16_HUMAN :
  • Q8N8M0
Domain:
  • Contains 1 N-acetyltransferase domain.
genes like me logo Genes that share domains with NAT16: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NAT16 Gene

Function for NAT16 Gene

Molecular function for NAT16 Gene

UniProtKB/Swiss-Prot Function: Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

Enzyme Numbers (IUBMB) for NAT16 Gene

Gene Ontology (GO) - Molecular Function for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004596 peptide alpha-N-acetyltransferase activity IBA --
GO:0008080 N-acetyltransferase activity --
genes like me logo Genes that share ontologies with NAT16: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAT16 Gene

Localization for NAT16 Gene

Gene Ontology (GO) - Cellular Components for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031416 NatB complex IBA --
genes like me logo Genes that share ontologies with NAT16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for NAT16 Gene

Pathways for NAT16 Gene

SuperPathways for NAT16 Gene

No Data Available

Interacting Proteins for NAT16 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300303%0d%0a9606.ENSP00000220751%0d%0a9606.ENSP00000300589%0d%0a
Selected Interacting proteins: ENSP00000300303 for NAT16 Gene via STRING

Gene Ontology (GO) - Biological Process for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0017196 N-terminal peptidyl-methionine acetylation IBA --
genes like me logo Genes that share ontologies with NAT16: view

No data available for Pathways by source for NAT16 Gene

Transcripts for NAT16 Gene

Unigene Clusters for NAT16 Gene

N-acetyltransferase 16 (GCN5-related, putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAT16 Gene

No ASD Table

Relevant External Links for NAT16 Gene

GeneLoc Exon Structure for
NAT16
ECgene alternative splicing isoforms for
NAT16

Expression for NAT16 Gene

mRNA expression in normal human tissues for NAT16 Gene

mRNA differential expression in normal tissues according to GTEx for NAT16 Gene

This gene is overexpressed in Pituitary (11.0), Brain - Nucleus accumbens (basal ganglia) (8.1), and Brain - Hypothalamus (6.6).

SOURCE GeneReport for Unigene cluster for NAT16 Gene Hs.213044

genes like me logo Genes that share expressions with NAT16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for NAT16 Gene

Orthologs for NAT16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT16 35
  • 99.19 (n)
  • 99.46 (a)
NAT16 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAT16 35
  • 79.78 (n)
  • 72.53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nat16 35
  • 59.75 (n)
  • 57.89 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003245 35
  • 59.4 (n)
  • 55.45 (a)
NAT16 36
  • 53 (a)
OneToOne
Species with no ortholog for NAT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT16 Gene

ENSEMBL:
Gene Tree for NAT16 (if available)
TreeFam:
Gene Tree for NAT16 (if available)

Paralogs for NAT16 Gene

No data available for Paralogs for NAT16 Gene

Variants for NAT16 Gene

Sequence variations from dbSNP and Humsavar for NAT16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs733965 -- 101,174,820(+) CAGAA(A/G)AAAAG intron-variant
rs734688 -- 101,175,565(+) CCCCA(C/T)AGACC intron-variant
rs740103 -- 101,171,998(-) ATTTC(C/T)GACGC utr-variant-3-prime
rs740104 -- 101,173,066(-) TTCGG(C/G)GACCC intron-variant
rs740105 -- 101,173,830(+) gcgat(C/T)cccta intron-variant

Relevant External Links for NAT16 Gene

HapMap Linkage Disequilibrium report
NAT16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAT16 Gene

Disorders for NAT16 Gene

No disorders were found for NAT16 Gene.

No data available for UniProtKB/Swiss-Prot for NAT16 Gene

Publications for NAT16 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for NI+-acetylhistidine synthesis. (PMID: 24121108) Yamada S. … Arikawa S. (Biochim. Biophys. Acta 2014) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for NAT16 Gene

Sources for NAT16 Gene

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