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Aliases for NAT16 Gene

Aliases for NAT16 Gene

  • N-Acetyltransferase 16 (Putative) 2 3
  • N-Acetyltransferase 16 (GCN5-Related, Putative) 2 3 5
  • C7orf52 3 4
  • Putative N-Acetyltransferase C7orf52 3
  • Chromosome 7 Open Reading Frame 52 2
  • Putative N-Acetyltransferase 16 3
  • EC 2.3.1.- 4

External Ids for NAT16 Gene

Previous HGNC Symbols for NAT16 Gene

  • C7orf52

Previous GeneCards Identifiers for NAT16 Gene

  • GC07M100814

Summaries for NAT16 Gene

GeneCards Summary for NAT16 Gene

NAT16 (N-Acetyltransferase 16 (Putative)) is a Protein Coding gene. GO annotations related to this gene include N-acetyltransferase activity and peptide alpha-N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT16 Gene

  • Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT16 Gene

Genomics for NAT16 Gene

Regulatory Elements for NAT16 Gene

Enhancers for NAT16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAT16 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAT16 Gene

Chromosome:
7
Start:
101,170,493 bp from pter
End:
101,195,908 bp from pter
Size:
25,416 bases
Orientation:
Minus strand

Genomic View for NAT16 Gene

Genes around NAT16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT16 Gene

Proteins for NAT16 Gene

  • Protein details for NAT16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8M0-NAT16_HUMAN
    Recommended name:
    Probable N-acetyltransferase 16
    Protein Accession:
    Q8N8M0
    Secondary Accessions:
    • B3KRS2
    • Q8NDR1

    Protein attributes for NAT16 Gene

    Size:
    369 amino acids
    Molecular mass:
    40521 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • NAT16 is the ortholog of the ectothermic vertebrates enzyme HISAT (AC I3J7Q8) responsible for the synthesis of N-acetyl-histidine (NAH). NAT16 protein, unlike fish HISAT, has only trace enzyme activity for NAH synthesis.

    Alternative splice isoforms for NAT16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT16 Gene

Proteomics data for NAT16 Gene at MOPED

Post-translational modifications for NAT16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT16 Gene

No data available for DME Specific Peptides for NAT16 Gene

Domains & Families for NAT16 Gene

Gene Families for NAT16 Gene

Protein Domains for NAT16 Gene

Suggested Antigen Peptide Sequences for NAT16 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8M0

UniProtKB/Swiss-Prot:

NAT16_HUMAN :
  • Contains 1 N-acetyltransferase domain.
Domain:
  • Contains 1 N-acetyltransferase domain.
genes like me logo Genes that share domains with NAT16: view

Function for NAT16 Gene

Molecular function for NAT16 Gene

UniProtKB/Swiss-Prot Function:
Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of this enzyme is unknown.

Enzyme Numbers (IUBMB) for NAT16 Gene

Gene Ontology (GO) - Molecular Function for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008080 N-acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with NAT16: view

Phenotypes for NAT16 Gene

genes like me logo Genes that share phenotypes with NAT16: view

Animal Model Products

CRISPR Products

miRNA for NAT16 Gene

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT16 Gene

Localization for NAT16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT16 Gene COMPARTMENTS Subcellular localization image for NAT16 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NAT16 Gene

Pathways & Interactions for NAT16 Gene

SuperPathways for NAT16 Gene

No Data Available

Interacting Proteins for NAT16 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000300303%0d%0a9606.ENSP00000220751%0d%0a9606.ENSP00000300589%0d%0a
Selected Interacting proteins: ENSP00000300303 for NAT16 Gene via STRING

Gene Ontology (GO) - Biological Process for NAT16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAT16: view

No data available for Pathways by source and SIGNOR curated interactions for NAT16 Gene

Drugs & Compounds for NAT16 Gene

No Compound Related Data Available

Transcripts for NAT16 Gene

Unigene Clusters for NAT16 Gene

N-acetyltransferase 16 (GCN5-related, putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAT16 Gene

No ASD Table

Relevant External Links for NAT16 Gene

GeneLoc Exon Structure for
NAT16
ECgene alternative splicing isoforms for
NAT16

Expression for NAT16 Gene

mRNA expression in normal human tissues for NAT16 Gene

mRNA differential expression in normal tissues according to GTEx for NAT16 Gene

This gene is overexpressed in Pituitary (x11.0), Brain - Nucleus accumbens (basal ganglia) (x8.1), and Brain - Hypothalamus (x6.6).

SOURCE GeneReport for Unigene cluster for NAT16 Gene Hs.213044

genes like me logo Genes that share expression patterns with NAT16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NAT16 Gene

Orthologs for NAT16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT16 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NAT16 35
  • 79.78 (n)
  • 72.53 (a)
chimpanzee
(Pan troglodytes)
Mammalia NAT16 35
  • 99.19 (n)
  • 99.46 (a)
NAT16 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nat16 35
  • 59.75 (n)
  • 57.89 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003245 35
  • 59.4 (n)
  • 55.45 (a)
NAT16 36
  • 53 (a)
OneToOne
Species with no ortholog for NAT16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT16 Gene

ENSEMBL:
Gene Tree for NAT16 (if available)
TreeFam:
Gene Tree for NAT16 (if available)

Paralogs for NAT16 Gene

No data available for Paralogs for NAT16 Gene

Variants for NAT16 Gene

Sequence variations from dbSNP and Humsavar for NAT16 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34985488 - 101,174,620(+) CCTCA(A/G)ACTCC reference, missense
rs965634 -- 101,180,494(+) GACTG(A/G)GGATG intron-variant, upstream-variant-2KB
rs1076276 -- 101,179,308(+) GAAGC(C/G)GGAGG intron-variant, upstream-variant-2KB
rs1106628 -- 101,180,110(-) GTGTC(C/T)GCGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs6952520 -- 101,193,617(+) agaga(C/T)ggggt intron-variant

Variation tolerance for NAT16 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.31; 81.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for NAT16 Gene

Disorders for NAT16 Gene

Relevant External Links for NAT16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT16

No disorders were found for NAT16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT16 Gene

Publications for NAT16 Gene

  1. An ectotherm homologue of human predicted gene NAT16 encodes histidine N-acetyltransferase responsible for NI+-acetylhistidine synthesis. (PMID: 24121108) Yamada S. … Arikawa S. (Biochim. Biophys. Acta 2014) 2 3 4 67
  2. The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity. (PMID: 22607974) Damgaard R.B. … Gyrd-Hansen M. (Mol. Cell 2012) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for NAT16 Gene

Sources for NAT16 Gene

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