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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAT16 Gene

protein-coding   GIFtS: 36
GCID: GC07M100814

N-Acetyltransferase 16 (GCN5-Related, Putative)

(Previous name: chromosome 7 open reading frame 52)
(Previous symbol: C7orf52)
  Search for NAT16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Acetyltransferase 16 (GCN5-Related, Putative)1 2
C7orf521 2 3
Chromosome 7 Open Reading Frame 521
Putative N-Acetyltransferase 162
Putative N-Acetyltransferase C7orf522
EC 2.3.1.-3

External Ids:    HGNC: 220301   Entrez Gene: 3756072   Ensembl: ENSG000001670117   UniProtKB: Q8N8M03   

Export aliases for NAT16 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NAT16 Gene: 
NAT16 (N-acetyltransferase 16 (GCN5-related, putative)) is a protein-coding gene. GO annotations related to this gene include N-acetyltransferase activity.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007933.15  NC_018918.2  NT_079596.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NAT16
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NAT16 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAT16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

NAT16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT16 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M100814:  view genomic region     (about GC identifiers)

Start:
100,813,774 bp from pter      End:
100,823,557 bp from pter
Size:
9,784 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 100,172,161-100,181,944     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NAT16_HUMAN, Q8N8M0 (See protein sequence)
Recommended Name: Putative N-acetyltransferase 16  
Size: 369 amino acids; 40521 Da
Secondary accessions: Q8NDR1

Explore the universe of human proteins at neXtProt for NAT16: NX_Q8N8M0

Explore proteomics data for NAT16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N8M0

  • NAT16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAT16 Protein Expression
    REFSEQ proteins: NP_940973.2  
    ENSEMBL proteins: 
     ENSP00000300303   ENSP00000395125   ENSP00000391769   ENSP00000394435  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000182 GNAT_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q8N8M0

    ProtoNet protein and cluster: Q8N8M0

    UniProtKB/Swiss-Prot: NAT16_HUMAN, Q8N8M0
    Similarity: Contains 1 N-acetyltransferase domain


    NAT16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008080N-acetyltransferase activity IEA--
         
    NAT16 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAT16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NAT16 (ENSP000003003034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NOD2ENSP000003005894STRING: ENSP00000300589
    RIPK2ENSP000002207514STRING: ENSP00000220751
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAT16

    Search CenterWatch for drugs/clinical trials and news about NAT16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAT16 gene: 
    NM_198571.2  

    Unigene Cluster for NAT16:

    N-acetyltransferase 16 (GCN5-related, putative)
    Hs.213044  [show with all ESTs]
    Unigene Representative Sequence: NM_198571
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300303(uc003uxy.2 uc003uxz.2) ENST00000455377 ENST00000444446
    ENST00000443096(uc003uya.1 uc003uyb.1)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK092119.1 AK096556.1 AL831911.1 BC037583.1 BC104841.1 

    5 DOTS entries:

    DT.65288621  DT.100018599  DT.97834535  DT.95355329  DT.121126563 

    20 AceView cDNA sequences:

    AL831911 AK096556 BI916227 AI914085 BM727073 AX747364 BE218557 AK092119 
    BQ640011 BV185387 AI912271 NM_198571 BC037583 BX119484 BG327091 BF346450 
    BM726057 H83792 BE549627 H83934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAT16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGAGACCCCT
    NAT16 Expression
    About this image


    See NAT16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAT16

    SOURCE GeneReport for Unigene cluster: Hs.213044
        SABiosciences Custom PCR Arrays for NAT16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NAT16 gene from 3/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia NAT161 N-acetyltransferase 16 (GCN5-related, putative) 79.98(n)
    72.53(a)
      100684972  XM_003434743.1  XP_003434791.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ736518.12   -- 73.45(n)    BQ736518.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000032451 putative N-acetyltransferase C7orf52-like 59.4(n)
    55.45(a)
      100003245  XM_001342820.1  XP_001342856.1 


    ENSEMBL Gene Tree for NAT16 (if available)
    TreeFam Gene Tree for NAT16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/296 SNPs in NAT16 are shown (see all 296)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737138031,2
    C--100813278(+) CCAATC/ACAGAG 1 -- int13Minor allele frequency- A:0.17WA EA 240
    rs680442651,2
    C,F--100813287(+) AGCAGG/CCTTCG 1 -- int16Minor allele frequency- C:0.09NA WA CSA EA 364
    rs1855824531,2
    --100813661(+) GGGAAC/GTCATT 1 -- int10--------
    rs1906421511,2
    --100813722(+) GAAAGA/GGGAAG 1 -- int10--------
    rs22861191,2
    C,F,H--100813831(+) GGAGGG/ATGGCA 1 -- ut314Minor allele frequency- A:0.01EA NS NA 172
    rs1392372191,2
    --100813994(+) TCCCAA/GCGAAC 1 -- ut310--------
    rs10065071,2
    C,F,A,H--100814034(+) ACCTAC/TGCATT 1 -- ut31 ese329Minor allele frequency- T:0.48NA EA MN NS WA 4632
    rs18595281,2
    C,F,O,A,H--100814078(+) CAGAGT/CGAAGT 1 -- ut31 ese326Minor allele frequency- C:0.44MN NS EA NA WA 2890
    rs1166924231,2
    C,F--100814389(+) GGAGAC/TAGCCC 1 -- ut311Minor allele frequency- T:0.05WA 118
    rs119754901,2
    C,H--100814444(+) CAGCTA/GGAACC 1 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for NAT16 (100813774 - 100823557 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NAT16: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAT16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NAT16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The ubiquitin ligase XIAP recruits LUBAC for NOD2 sign aling in inflammation and innate immunity. (PubMed id 22607974)1 Damgaard R.B....Gyrd-Hansen M. (2012)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (2003)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 375607 HGNC: 22030 AceView: FLJ39237 Ensembl:ENSG00000167011 euGenes: HUgn375607
    ECgene: NAT16 H-InvDB: NAT16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAT16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAT16 gene:
    Search GeneIP for patents involving NAT16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for NAT16
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     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for NAT16
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT16
     SwitchGear 3'UTR luciferase reporter plasmids for NAT16
     SwitchGear Promoter luciferase reporter plasmids for NAT16
     Search ThermoFisher Antibodies for NAT16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT16
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NAT16
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAT16
    Customized:
     lentivirus for stable overexpression of NAT16
     lentivirus expression plasmids for stable overexpression of NAT16
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     Search LSBio for Antibodies for NAT16
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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