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Aliases for NAT14 Gene

Aliases for NAT14 Gene

  • N-Acetyltransferase 14 (Putative) 2 3
  • N-Acetyltransferase 14 (GCN5-Related, Putative) 2 3 5
  • K562 Cells-Derived Leucine Zipper-Like Protein 1 2 3
  • K562 Cell-Derived Leucine-Zipper-Like Protein 1 3 4
  • KLP1 3 4
  • K562 Cells-Derived Leucine-Zipper-Like Protein 1 3
  • N-Acetyltransferase 14 2
  • EC 2.3.1.- 4
  • EC 2.3.1 63

External Ids for NAT14 Gene

Previous GeneCards Identifiers for NAT14 Gene

  • GC19P060689
  • GC19P055996
  • GC19P052309

Summaries for NAT14 Gene

GeneCards Summary for NAT14 Gene

NAT14 (N-Acetyltransferase 14 (Putative)) is a Protein Coding gene. Among its related pathways are Phase II conjugation. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT14 Gene

  • Probable acetyltransferase that binds the 5-GGACTACAG-3 sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT14 Gene

Genomics for NAT14 Gene

Regulatory Elements for NAT14 Gene

Promoters for NAT14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAT14 on UCSC Golden Path with GeneCards custom track

Genomic Location for NAT14 Gene

Chromosome:
19
Start:
55,485,004 bp from pter
End:
55,487,568 bp from pter
Size:
2,565 bases
Orientation:
Plus strand

Genomic View for NAT14 Gene

Genes around NAT14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT14 Gene

Proteins for NAT14 Gene

  • Protein details for NAT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY8-NAT14_HUMAN
    Recommended name:
    N-acetyltransferase 14
    Protein Accession:
    Q8WUY8
    Secondary Accessions:
    • Q8TDY7
    • Q9NS72

    Protein attributes for NAT14 Gene

    Size:
    206 amino acids
    Molecular mass:
    21650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAT14 Gene

Proteomics data for NAT14 Gene at MOPED

Selected DME Specific Peptides for NAT14 Gene

Post-translational modifications for NAT14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT14 Gene

Domains & Families for NAT14 Gene

Gene Families for NAT14 Gene

Protein Domains for NAT14 Gene

Suggested Antigen Peptide Sequences for NAT14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUY8

UniProtKB/Swiss-Prot:

NAT14_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the camello family.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the camello family.
genes like me logo Genes that share domains with NAT14: view

Function for NAT14 Gene

Molecular function for NAT14 Gene

UniProtKB/Swiss-Prot Function:
Probable acetyltransferase that binds the 5-GGACTACAG-3 sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

Enzyme Numbers (IUBMB) for NAT14 Gene

genes like me logo Genes that share phenotypes with NAT14: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT14 Gene

Localization for NAT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT14 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT14 Gene COMPARTMENTS Subcellular localization image for NAT14 gene
Compartment Confidence
nucleus 5
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NAT14 Gene

Pathways & Interactions for NAT14 Gene

SuperPathways for NAT14 Gene

Superpath Contained pathways
1 Phase II conjugation
genes like me logo Genes that share pathways with NAT14: view

Pathways by source for NAT14 Gene

1 BioSystems pathway for NAT14 Gene

Gene Ontology (GO) - Biological Process for NAT14 Gene

None

No data available for SIGNOR curated interactions for NAT14 Gene

Drugs & Compounds for NAT14 Gene

(1) Additional Compounds for NAT14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Coproporphyrinogen III
  • 3,8,13,17-Tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,18-tetrapropanoate
  • 3,8,13,17-Tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,18-tetrapropanoic acid
  • 5,10,15,20,22,24-Hexahydro-3,8,13,17-tetramethyl-2,7,12,18-Porphinetetrapropionate
  • 5,10,15,20,22,24-Hexahydro-3,8,13,17-tetramethyl-2,7,12,18-Porphinetetrapropionic acid
  • 5,10,15,20,22,24-Hexahydro-3,8,13,17-tetramethyl-21H,23H-Porphine-2,7,12,18-tetrapropanoate
2624-63-7
genes like me logo Genes that share compounds with NAT14: view

Transcripts for NAT14 Gene

Unigene Clusters for NAT14 Gene

N-acetyltransferase 14 (GCN5-related, putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAT14 Gene

No ASD Table

Relevant External Links for NAT14 Gene

GeneLoc Exon Structure for
NAT14
ECgene alternative splicing isoforms for
NAT14

Expression for NAT14 Gene

mRNA expression in normal human tissues for NAT14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAT14 Gene

This gene is overexpressed in Bone (34.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAT14 Gene



SOURCE GeneReport for Unigene cluster for NAT14 Gene Hs.31854

mRNA Expression by UniProt/SwissProt for NAT14 Gene

Q8WUY8-NAT14_HUMAN
Tissue specificity: Expressed in K-562 and HeLa cell lines and in brain.
genes like me logo Genes that share expression patterns with NAT14: view

Protein tissue co-expression partners for NAT14 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NAT14 Gene

Orthologs for NAT14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAT14 35
  • 88.83 (n)
  • 96.12 (a)
NAT14 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAT14 35
  • 88.51 (n)
  • 95.63 (a)
NAT14 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nat14 35
  • 87.06 (n)
  • 95.15 (a)
Nat14 16
Nat14 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAT14 35
  • 99.84 (n)
  • 99.51 (a)
NAT14 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nat14 35
  • 86.41 (n)
  • 93.69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nat14 35
  • 58.03 (n)
  • 51.81 (a)
zebrafish
(Danio rerio)
Actinopterygii NAT14 36
  • 28 (a)
OneToOne
Species with no ortholog for NAT14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT14 Gene

ENSEMBL:
Gene Tree for NAT14 (if available)
TreeFam:
Gene Tree for NAT14 (if available)

Paralogs for NAT14 Gene

No data available for Paralogs for NAT14 Gene

Variants for NAT14 Gene

Sequence variations from dbSNP and Humsavar for NAT14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745450 -- 55,485,572(-) CTTCC(C/T)AGATC intron-variant
rs3745451 -- 55,485,536(-) CCAAG(A/C)GAGGA intron-variant
rs75176024 -- 55,485,317(+) GGGGC(A/G)CTGGG intron-variant
rs73608725 -- 55,485,092(+) CACAG(C/T)TCGGT upstream-variant-2KB
rs78400453 -- 55,486,475(+) GCTCC(A/C/G/T)CCTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NAT14 Gene

Variant ID Type Subtype PubMed ID
nsv912457 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv912473 CNV Loss 21882294
nsv912478 CNV Loss 21882294
dgv4022n71 CNV Loss 21882294
dgv4023n71 CNV Loss 21882294
dgv4024n71 CNV Loss 21882294
nsv458833 CNV Loss 19166990
nsv912486 CNV Loss 21882294
dgv4025n71 CNV Loss 21882294
nsv2552 CNV Insertion 18451855
nsv912489 CNV Loss 21882294

Variation tolerance for NAT14 Gene

Gene Damage Index Score: 6.19; 75.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT14 Gene

HapMap Linkage Disequilibrium report
NAT14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT14 Gene

Disorders for NAT14 Gene

Relevant External Links for NAT14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT14

No disorders were found for NAT14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT14 Gene

Publications for NAT14 Gene

  1. Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein. (PMID: 10873651) Takahashi S. … Hayashi N. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
  2. Genomic structure and regulation of a novel human gene, Klp1. (PMID: 11779635) Takahashi S. … Sasaki T. (Biochim. Biophys. Acta 2001) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for NAT14 Gene

Sources for NAT14 Gene

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