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NAT14 Gene

protein-coding GIFtS: 44

GC19P060689

N-acetyltransferase 14 (GCN5-related, putative)
(Previous name: N-acetyltransferase 14 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.3.1.- ^³
KLP1 ^¹, ², ³

Descriptions
K562 cell-derived leucine-zipper-like protein 1 ^², ³
K562 cells-derived leucine zipper-like protein 1 ^²
K562 cells-derived leucine-zipper-like protein 1 ^²
N-acetyltransferase 14 ^¹, ²
N-acetyltransferase 14 (GCN5-related, putative) ^²

External Ids
HGNC: 28918¹
Entrez Gene: 57106²
UniProtKB: Q8WUY8³
Ensembl: ENSG00000090971⁷

Search outside databases for aliases for NAT14 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NAT14_HUMAN, Q8WUY8

Function: Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen

oxidase promoter. Able to activate transcription of a reporter construct in vitro

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42

NAT14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P060689: (about GC identifiers)

Start:	60,688,406 bp from pter
End:	60,690,747 bp from pter
Size:	2,342 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NAT14_HUMAN, Q8WUY8 (See protein sequence)

Recommended Name: N-acetyltransferase 14

Size: 206 amino acids; 21650 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Secondary accessions: Q8TDY7 Q9NS72

REFSEQ proteins: NP_065111.1

ENSEMBL proteins:

ENSP00000205194

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NAT14)
	Human Recombinant Proteins from Abnova (KLP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	10873651
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for NAT14:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NAT14), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (KLP1)
	Novus Biologicals Antibody for NAT14

Assays for NAT14:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WUY8

ProtoNet protein and cluster: Q8WUY8

1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase

UniProtKB/Swiss-Prot: NAT14_HUMAN, Q8WUY8

Similarity: Belongs to the camello family

Similarity: Contains 1 N-acetyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT14)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KLP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020378

Applied Biosystems Silencer® siRNAs for NAT14

Sigma-Aldrich siRNA for NAT14

Sigma-Aldrich shRNA for NAT14

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAT14
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_020378
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020378
untagged cDNA clone in CMV expression vector: NM_020378

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020378

UniProtKB/Swiss-Prot: NAT14_HUMAN, Q8WUY8

Function: Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen

oxidase promoter. Able to activate transcription of a reporter construct in vitro

Enzyme Number (IUBMB): EC 2.3.1.-

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008080	N-acetyltransferase activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016563	transcription activator activity	NAS	10873651
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006352	transcription initiation	NAS	10873651
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT14

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT14)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (KLP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020378

Sigma-Aldrich siRNA for NAT14

Sigma-Aldrich shRNA for NAT14

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_020378

REFSEQ mRNAs for NAT14 gene:

NM_020378.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_020378

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020378
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_020378
                                 untagged cDNA clone in CMV expression vector: NM_020378

Additional cDNA sequence:

AB038651.1 BC019079.2 CR590931.1 CR592269.1 CR611579.1 CR619062.1

4 DOTS entries:

DT.415001 DT.91726103 DT.95169434 DT.95169436

24/166 AceView cDNA sequences (see all 166 ):

AI271993 BC019079 AW304702 CR592269 BM841144 BX406228 BM662627 AI356621

BI917018 CA311022 BU947894 BQ787460 BQ581444 BF197187 AA340619 NM_020378

AI937377 CR611579 CA848290 BM695014 BQ574711 AW167906 AA025296 AI097152

highest scoring ESTs for NAT14:

AA041307 AA758007 AA024535 AA025296 AA041331 AA317613 AA322561 AA340619 AA430115 AA504715

Unigene Clusters for NAT14:

N-acetyltransferase 14 (GCN5-related, putative)

Hs.31854 [show with all ESTs], Hs.719312 [show with all ESTs]

Unigene Representative Sequences: BX406227, BM805249

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000205194

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT14 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAT14

¹ / ² / ³

4 probe-sets matching NAT14 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
65658_at²^{, 3}	U95-C	1	1.00	1.00	0.97	1.15	AA758007	1.00	1.00	1.00	1
49239_s_at²^{, 3}	U95-B	1	1.00	1.00	0.98	0.85	AA041307	1.00	1.00	1.00	1
223284_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AB038651	0.80	1.00	0.91	1
223284_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAT14 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.31854 Hs.719312
UniProtKB/Swiss-Prot: NAT14_HUMAN, Q8WUY8
Tissue specificity: Expressed in K562 cells, HeLa cells and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAT14 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAT14¹	--	N-acetyltransferase 14 (GCN5-related, putative)	88.51(n) 95.63(a)	611287 XM_848932.1 XP_854025.1
chimpanzee (Pan troglodytes)	NAT14¹	--	N-acetyltransferase 14 (GCN5-related, putative)	99.84(n) 99.51(a)	736425 XM_001135806.1 XP_001135806.1
cow (Bos taurus)	NAT14¹	--	N-acetyltransferase 14 (GCN5-related, putative)	88.83(n) 96.12(a)	532809 NM_001037245.1 NP_001032322.1
rat (Rattus norvegicus)	Nat14¹	--	N-acetyltransferase 14	86.41(n) 93.69(a)	361500 XM_341779.3 XP_341780.3
mouse (Mus musculus)	Nat14^{1, 5}	7⁵	N-acetyltransferase 14^{1, 5}	87.06(n)¹ 95.15(a)¹	269854¹ NM_201355.2¹ NP_958743.1¹ AK078272⁵ AK158627⁵ (see all 7)

About this table Species with no ortholog for NAT14

ENSEMBL Gene Tree for NAT14

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

3 NCBI SNPs in NAT14 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3745450^1,2	C,F,H	60688751(-)	`CTTCCC/TAGATC`	1	--	int¹		9		EA EU WA	2324
	rs3745451^1,2	F,H	60688715(-)	`CCAAGC/AGAGGA`	1	--	int¹		5		EA EU WA	1886
--	rs73608725^1,2	--	60688271(+)	`CACAGC/TTCGGT`	1	--	ng5¹		0	--	--	--	--

About this table
The following additional 28 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs2059138	rs7478	rs7479	rs12984637	rs10423962	rs11084399	rs2902752
rs11550705	rs2864437	rs11667987	rs2399	rs1559173	rs12463160	rs4274529
rs4405662	rs12981134	rs12984395	rs1477334	rs721781	rs929794	rs12057
rs34980175	rs4801305	rs2287793	rs2864436	rs889090	rs2059137	rs4801677

HapMap Linkage Disequilibrium images for NAT14 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for NAT14 gene:

Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein. (PubMed id 10873651)^{1, 2, 3, 4} Takahashi S.... Hayashi N. (2000)
Genomic structure and regulation of a novel human gene, Klp1. (PubMed id 11779635)^{1, 3, 4} Takahashi S.... Sasaki T. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 57106	HGNC: 28918	AceView: KLP1	Ensembl:ENSG00000090971	euGenes: HUgn57106
ECgene: NAT14	H-InvDB: NAT14

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NAT14
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAT14:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAT14-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAT14		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAT14		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (KLP1)
	Antibodies (KLP1)
	Chimera RNAi (KLP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (NAT14)
	Antibodies (NAT14)

Search OriGene for NAT14

Search Tocris compounds for NAT14

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NAT14

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NAT14 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for NAT14

Summaries
for NAT14

Genomic Location
for NAT14

Proteins
for NAT14

Protein Domains/
Families
for NAT14

Gene Function
for NAT14

Pathways & Interactions
for NAT14

Drugs & Compounds
for NAT14

Transcripts
for NAT14

Expression
for NAT14

Orthologs
for NAT14

Paralogs
for NAT14

SNPs/Variants
for NAT14

Disorders & Mutations
for NAT14

Medical News
for NAT14

Publications
for NAT14

Search for NAT14

Genome Databases showing NAT14

Other Databases showing NAT14

Specialized Databases showing NAT14

Licensable Technologies
for NAT14

Services
for NAT14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAT14 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor NAT14

Summariesfor NAT14

Genomic Locationfor NAT14

Proteinsfor NAT14

Protein Domains/Familiesfor NAT14

Gene Functionfor NAT14

Pathways & Interactionsfor NAT14

Drugs & Compoundsfor NAT14

Transcriptsfor NAT14

Expression for NAT14

Orthologsfor NAT14

Paralogsfor NAT14

SNPs/Variantsfor NAT14

Disorders & Mutationsfor NAT14

Medical Newsfor NAT14

Publicationsfor NAT14

Search for NAT14

Genome Databases showing NAT14

Other Databases showing NAT14

Specialized Databases showing NAT14

Licensable Technologiesfor NAT14

Servicesfor NAT14

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAT14

Summaries
for NAT14

Genomic Location
for NAT14

Proteins
for NAT14

Protein Domains/
Families
for NAT14

Gene Function
for NAT14

Pathways & Interactions
for NAT14

Drugs & Compounds
for NAT14

Transcripts
for NAT14

Expression
for NAT14

Orthologs
for NAT14

Paralogs
for NAT14

SNPs/Variants
for NAT14

Disorders & Mutations
for NAT14

Medical News
for NAT14

Publications
for NAT14

Licensable Technologies
for NAT14

Services
for NAT14