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Aliases for NAT14 Gene

Aliases for NAT14 Gene

  • N-Acetyltransferase 14 (Putative) 2 3 5
  • N-Acetyltransferase 14 (GCN5-Related, Putative) 2 3
  • K562 Cell-Derived Leucine-Zipper-Like Protein 1 3 4
  • N-Acetyltransferase 14 2 3
  • KLP1 3 4
  • K562 Cells-Derived Leucine Zipper-Like Protein 1 2
  • K562 Cells-Derived Leucine-Zipper-Like Protein 1 3
  • EC 2.3.1.- 4
  • EC 2.3.1 61

External Ids for NAT14 Gene

Previous GeneCards Identifiers for NAT14 Gene

  • GC19P060689
  • GC19P055996
  • GC19P052309

Summaries for NAT14 Gene

GeneCards Summary for NAT14 Gene

NAT14 (N-Acetyltransferase 14 (Putative)) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT14 Gene

  • Probable acetyltransferase that binds the 5-GGACTACAG-3 sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT14 Gene

Genomics for NAT14 Gene

Regulatory Elements for NAT14 Gene

Enhancers for NAT14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055519 1.6 FANTOM5 Ensembl ENCODE 25.9 +35.2 35206 1.0 HDGF ATF1 ZNF493 ZNF133 GLI4 YBX1 ZNF416 ZNF548 FOS MCM3 FIZ1 ZNF580 NAT14 U2AF2 SHISA7 ZNF667 ZNF667-AS1 SSC5D SBK3 LOC100506374
GH19F055503 1.3 Ensembl ENCODE 18.1 +19.0 18965 1.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF416 ZNF143 ZNF548 U2AF2 ZNF667 FIZ1 ZNF667-AS1 NAT14 LOC100506374 ZNF580 ZNF582-AS1 ENSG00000267523 KMT5C
GH19F055405 1.4 FANTOM5 ENCODE 13.8 -77.6 -77579 3.7 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF416 ZNF207 ENSG00000269873 NAT14 MIR6805 LOC100506374 ZNF581 U2AF2 ZNF582-AS1 ZNF580 FIZ1 RPL28
GH19F055215 1.2 ENCODE 13.7 -268.3 -268300 2.9 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 U2AF2 LENG8-AS1 ENSG00000235681 ENSG00000267523 ZNF581 ZNF628 ZNF580 ENSG00000267096 KMT5C RFPL4AP1
GH19F055652 1.2 ENCODE 13.7 +172.0 172002 8.0 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF580 RFPL4AP1 RPL13P13 NAT14 ENSG00000269696 ZNF582-AS1 FIZ1 ZNF667 ENSG00000269275 ZNF470
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAT14 on UCSC Golden Path with GeneCards custom track

Promoters for NAT14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000349015 196 1201 HDAC1 ATF1 ZNF76 ARID4B SIN3A BMI1 ZBTB40 ETS1 GLIS2 ELK1

Genomic Location for NAT14 Gene

Chromosome:
19
Start:
55,485,004 bp from pter
End:
55,487,568 bp from pter
Size:
2,565 bases
Orientation:
Plus strand

Genomic View for NAT14 Gene

Genes around NAT14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT14 Gene

Proteins for NAT14 Gene

  • Protein details for NAT14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUY8-NAT14_HUMAN
    Recommended name:
    N-acetyltransferase 14
    Protein Accession:
    Q8WUY8
    Secondary Accessions:
    • Q8TDY7
    • Q9NS72

    Protein attributes for NAT14 Gene

    Size:
    206 amino acids
    Molecular mass:
    21650 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAT14 Gene

Selected DME Specific Peptides for NAT14 Gene

Q8WUY8:
  • LSVREMRE
  • KLGLRARWGSLPPPGGLGGPWVAVRGSGDVCGVLALAPG

Post-translational modifications for NAT14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAT14 Gene

Domains & Families for NAT14 Gene

Gene Families for NAT14 Gene

Protein Domains for NAT14 Gene

Suggested Antigen Peptide Sequences for NAT14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUY8

UniProtKB/Swiss-Prot:

NAT14_HUMAN :
  • Contains 1 N-acetyltransferase domain.
  • Belongs to the camello family.
Domain:
  • Contains 1 N-acetyltransferase domain.
Family:
  • Belongs to the camello family.
genes like me logo Genes that share domains with NAT14: view

Function for NAT14 Gene

Molecular function for NAT14 Gene

UniProtKB/Swiss-Prot Function:
Probable acetyltransferase that binds the 5-GGACTACAG-3 sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro.

Enzyme Numbers (IUBMB) for NAT14 Gene

Gene Ontology (GO) - Molecular Function for NAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0008080 N-acetyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with NAT14: view
genes like me logo Genes that share phenotypes with NAT14: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAT14 Gene

Localization for NAT14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT14 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT14 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10873651
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NAT14: view

Pathways & Interactions for NAT14 Gene

genes like me logo Genes that share pathways with NAT14: view

Pathways by source for NAT14 Gene

1 BioSystems pathway for NAT14 Gene

Gene Ontology (GO) - Biological Process for NAT14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation NAS 10873651
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045893 positive regulation of transcription, DNA-templated NAS 10873651
genes like me logo Genes that share ontologies with NAT14: view

No data available for SIGNOR curated interactions for NAT14 Gene

Drugs & Compounds for NAT14 Gene

(1) Additional Compounds for NAT14 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Coproporphyrinogen III
  • 3,8,13,17-Tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,18-tetrapropanoate
  • 3,8,13,17-Tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,18-tetrapropanoic acid
  • 5,10,15,20,22,24-Hexahydro-3,8,13,17-tetramethyl-2,7,12,18-Porphinetetrapropionate
  • 5,10,15,20,22,24-Hexahydro-3,8,13,17-tetramethyl-2,7,12,18-Porphinetetrapropionic acid
  • 5,10,15,20,22,24-Hexahydro-3,8,13,17-tetramethyl-21H,23H-Porphine-2,7,12,18-tetrapropanoate
2624-63-7
genes like me logo Genes that share compounds with NAT14: view

Transcripts for NAT14 Gene

Unigene Clusters for NAT14 Gene

N-acetyltransferase 14 (GCN5-related, putative):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT14 Gene

No ASD Table

Relevant External Links for NAT14 Gene

GeneLoc Exon Structure for
NAT14
ECgene alternative splicing isoforms for
NAT14

Expression for NAT14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAT14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAT14 Gene

This gene is overexpressed in Bone (34.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAT14 Gene



Protein tissue co-expression partners for NAT14 Gene

NURSA nuclear receptor signaling pathways regulating expression of NAT14 Gene:

NAT14

SOURCE GeneReport for Unigene cluster for NAT14 Gene:

Hs.31854

mRNA Expression by UniProt/SwissProt for NAT14 Gene:

Q8WUY8-NAT14_HUMAN
Tissue specificity: Expressed in K-562 and HeLa cell lines and in brain.
genes like me logo Genes that share expression patterns with NAT14: view

Primer Products

No data available for mRNA differential expression in normal tissues for NAT14 Gene

Orthologs for NAT14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NAT14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT14 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia NAT14 34 35
  • 88.83 (n)
dog
(Canis familiaris)
Mammalia NAT14 34 35
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia Nat14 34 16 35
  • 87.06 (n)
rat
(Rattus norvegicus)
Mammalia Nat14 34
  • 86.41 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nat14 34
  • 58.03 (n)
zebrafish
(Danio rerio)
Actinopterygii NAT14 35
  • 28 (a)
OneToOne
Species where no ortholog for NAT14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NAT14 Gene

ENSEMBL:
Gene Tree for NAT14 (if available)
TreeFam:
Gene Tree for NAT14 (if available)

Paralogs for NAT14 Gene

No data available for Paralogs for NAT14 Gene

Variants for NAT14 Gene

Sequence variations from dbSNP and Humsavar for NAT14 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111286193 -- 55,484,474(+) AGACC(C/G)GAGTC upstream-variant-2KB, utr-variant-3-prime
rs111718040 -- 55,483,824(+) AATTC(C/T)AGTGG upstream-variant-2KB, reference, synonymous-codon
rs112407198 -- 55,484,034(+) CAGAC(C/T)CGACT upstream-variant-2KB, reference, synonymous-codon
rs112775775 -- 55,483,781(+) GGTGA(C/G)CACGG upstream-variant-2KB, reference, missense
rs112828267 -- 55,484,861(+) GGCCG(A/G)CTCCT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAT14 Gene

Variant ID Type Subtype PubMed ID
nsv2552 CNV insertion 18451855
nsv458833 CNV loss 19166990
nsv580343 CNV loss 21841781
nsv953624 CNV deletion 24416366

Variation tolerance for NAT14 Gene

Gene Damage Index Score: 6.19; 75.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT14 Gene

Disorders for NAT14 Gene

Relevant External Links for NAT14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT14

No disorders were found for NAT14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT14 Gene

Publications for NAT14 Gene

  1. Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein. (PMID: 10873651) Takahashi S. … Hayashi N. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. Genomic structure and regulation of a novel human gene, Klp1. (PMID: 11779635) Takahashi S. … Sasaki T. (Biochim. Biophys. Acta 2001) 3 4 22 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3 64

Products for NAT14 Gene

Sources for NAT14 Gene

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