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NAT13 Gene

protein-coding   GIFtS: 50

GC03M114921
N-acetyltransferase 13 (GCN5-related)
(Previous names: Mak3 homolog (S. cerevisiae), N-acetyltransferase 13 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MAK3)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 2.3.1.- 3
FLJ13194 1, 2
MAK3 2, 3
NAT5 1, 2, 3, 5
SAN 2, 5
San 1
hNAT5 2, 3
hSAN 2, 3
Descriptions
Mak3 homolog 2
Mak3 homolog (S. cerevisiae) 1
N-acetyltransferase 13 1, 2
N-acetyltransferase 13 (GCN5-related) 2
N-acetyltransferase 5 2, 3
N-acetyltransferase san homolog 3
separation anxiety 2
External Ids
HGNC: 295331
Entrez Gene: 802182
UniProtKB: Q9GZZ13
Ensembl: ENSG000001215797
Search outside databases for aliases for NAT13 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: NAT13_HUMAN, Q9GZZ1
Function: Probable catalytic component of the ARD1A-NARG1 complex which displays alpha (N-terminal)
acetyltransferase activity

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NAT13 gene  

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.31

NAT13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M114921:     (about GC identifiers)

Start:
114,920,531 bp from pter
End:
114,947,786 bp from pter
Size:
27,256 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAT13_HUMAN, Q9GZZ1 (See protein sequence)
Recommended Name: N-acetyltransferase 13  
Size: 169 amino acids; 19398 Da
Subunit: Interacts with MAK10 (By similarity). Interacts with NARG1 and ARD1A
Subcellular location: Cytoplasm
PDB structure from and Proteopedia :
2OB0 (3D)    2PSW (3D)    
Secondary accessions: Q68DQ1
Alternative splicing: 2 isoforms:  Q9GZZ1-1   Q9GZZ1-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_079422.1  

    ENSEMBL proteins: 
    ENSP00000240922 ENSP00000373172 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (MAK3)
                  OriGene Purified Recombinant Human Protein: NAT13 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IDA16507339
    About this table

    Antibodies for NAT13: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NAT13
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for NAT13

    Assays for NAT13: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000182 GCN5-rel_AcTrfase
     IPR016181 Acyl_CoA_acyltransferase


       GeneDecks  NAT13 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9GZZ1

    ProtoNet protein and cluster: Q9GZZ1

    UniProtKB/Swiss-Prot: NAT13_HUMAN, Q9GZZ1
    Similarity: Belongs to the acetyltransferase family. GNAT subfamily
    Similarity: Contains 1 N-acetyltransferase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NAT13)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025146

                  Applied Biosystems Silencer® siRNAs for NAT13

                  Sigma-Aldrich siRNA for NAT13  
                         Sigma-Aldrich shRNA for NAT13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for NAT13
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_025146
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_025146
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_025146 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_025146

    UniProtKB/Swiss-Prot: NAT13_HUMAN, Q9GZZ1
    Function: Probable catalytic component of the ARD1A-NARG1 complex which displays alpha (N-terminal)
    acetyltransferase activity
    Enzyme Number (IUBMB): EC 2.3.1.- 

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI16507339
    GO:0008080 N-acetyltransferase activity IEA--
    GO:0008415 acyltransferase activity IEA--
    GO:0016740 transferase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5 Interacting proteins for NAT13 (ENSP000002409223) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HCN4ENSP000002619173STRING (score=.744)
    GJA5ENSP000003582403STRING (score=.72)
    GJA1ENSP000002825613STRING (score=.706)
    USH1GENSP000003200763STRING (score=.706)
    --ENSP000003566683STRING (score=.834)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006474 N-terminal protein amino acid acetylation TAS16507339
    GO:0008152 metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NAT13

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NAT13)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_025146

                  Sigma-Aldrich siRNA for NAT13  
                         Sigma-Aldrich shRNA for NAT13  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_025146  

    REFSEQ mRNAs for NAT13 gene: 

    NM_025146.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_025146  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_025146
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_025146
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_025146 

    Additional cDNA sequence: 

    AK022540.1 AK023090.1 AK023256.1 AK296456.1 AK307184.1 AK311403.1 AK315876.1 BC012731.2 
    CR603927.1 CR749314.1 

    24 DOTS entries:

    DT.80100959  DT.120919577  DT.101983516  DT.100663051  DT.120919499  DT.104062  DT.100829009  DT.91935021 
    DT.120919388  DT.120919412  DT.120919362  DT.120919454  DT.87011728  DT.100641093  DT.120919378  DT.121312617 
    DT.99991222  DT.120919450  DT.120919486  DT.92394648  DT.92449061  DT.95329606  DT.95329607  DT.120919439 

    24/521 AceView cDNA sequences (see all 521 ):

    R68785 BU631770 CD370557 BG257648 BF038207 BQ001439 BQ060807 AW303898 
    BQ001802 BQ220889 AI262664 AI937352 AW118297 AW572694 BQ921324 AW770843 
    AW503374 BM829036 BU730451 N44858 AW167801 BG530304 BU522108 BE501022 

    highest scoring ESTs for NAT13:

    AA160707 AK023090 AK023256 AL550661 AL598465 AL601126 AL705356 AU127197 AU130562 AU131589 

    Unigene Cluster for NAT13:

    N-acetyltransferase 13 (GCN5-related)
    Hs.596074  [show with all ESTs]
    Unigene Representative Sequence: BC012731


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NAT13

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
    SP1:                          -                                       
    SP2:                          -                                       
    SP3:                    -     -                                       
    SP4:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for NAT13

    2 Ensembl transcripts including schematic representations:
    ENST00000240922  ENST00000313396  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NAT13 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NAT13

    1 / 2 / 3

    5 probe-sets matching NAT13 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    49027_at2, 3 U95-C 1 1.00 1.00 1.00 1.00 N63013 0.80 1.00 0.91 1

    222393_s_at2, 3 U133-B 1 1.00 1.00 -- -- AU149868 0.40 1.00 0.76 1

    217745_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_025146 0.60 1.00 0.82 1

    222393_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    217745_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTGTGGTGGT

    SOURCE GeneReport for Unigene cluster: Hs.596074
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for NAT13 gene from 5/20 species (see all 20 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NAT131   -- N-acetyltransferase 13 (GCN5-related) 97.99(n)
    100(a)
    478569  XM_535745.2  XP_535745.2 
    chimpanzee
    (Pan troglodytes)
    NAT131   -- N-acetyltransferase 13 (GCN5-related) 99.4(n)
    98.81(a)
    470884  XM_526267.2  XP_526267.2 
    cow
    (Bos taurus)
    NAT131   -- N-acetyltransferase 13 (GCN5-related) 95.07(n)
    100(a)
    517211  NM_001075750.1  NP_001069218.1 
    rat
    (Rattus norvegicus)
    Nat131   -- N-acetyltransferase 13 92.31(n)
    97.04(a)
    288108  XM_213624.4  XP_213624.2 
    mouse
    (Mus musculus)
    Nat131, 5 165
    N-acetyltransferase 131, 5 92.26(n)1
    98.81(a)1
    721171  NM_028108.31  NP_082384.11 
     AI1198545  AI3907125  (see all 33)
    About this table        Species with no ortholog for NAT13

    ENSEMBL Gene Tree for NAT13
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/89 NCBI SNPs in NAT13 are shown (see all 89 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs76480211,2
    C,F,H114920726(+) TTTCAA/GTTGAT 1 -- ut317Minor allele frequency- G:0.02EU EA WA NA 560
    --
    rs64381661,2
    A,C,H114922609(+) GAAAAA/CCAAAC 1 -- ut314Minor allele frequency- C:0.00EU EA WA 412
    --
    rs13499421,2
    H114920300(+) TTTCCC/TTCTCA 1 -- ng514Minor allele frequency- T:0.00EU EA WA 420
    --
    rs13781801,2
    H114920302(+) TCCCTC/TTCATT 1 -- ng519Minor allele frequency- T:0.00EA NA MN EU WA 760
    rs345886341,2
    C,F114924508(-) ACAGGA/GACTAA 1 G/G syn11Minor allele frequency- G:0.04NA 74
    rs25669701,2
    A,C,F,H,O114944813(-) ACGAAG/ACCAGT 1 -- int113Minor allele frequency- A:0.35NA EU EA WA 1156
    rs37327931,2
    A,C,F,H114924888(-) ACCTAG/TTAAGT 1 -- int17Minor allele frequency- T:0.31NA EU EA WA 562
    rs27123481,2
    A,C,F,H114943304(+) GCTTTC/ACTAAG 1 -- int14Minor allele frequency- A:0.36EU EA WA 420
    rs9217411,2
    A,C,F,H114926741(+) CTTCAA/CTACTG 1 -- int19Minor allele frequency- C:0.36MN EU EA WA NA 958
    rs76495901,2
    A,C,F,H114929957(+) GTGTAT/CGTACA 1 -- int16Minor allele frequency- C:0.33NA EU EA 410
    About this table

    HapMap Linkage Disequilibrium images for NAT13 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610834

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    8 PubMed articles for NAT13 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 80218 HGNC: 29533 AceView: MAK3 Ensembl:ENSG00000121579 euGenes: HUgn80218
    ECgene: NAT13 H-InvDB: NAT13
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NAT13:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NAT13-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NAT13 Antibodies for NAT13
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NAT13 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for NAT13




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for NAT13

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