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NAT11 Gene

protein-coding GIFtS: 46

GC11P063464

N-acetyltransferase 11 (GCN5-related, putative)
(Previous name: N-acetyltransferase 11 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.3.1.- ^³
FLJ13848 ^¹, ²

Descriptions
N-acetyltransferase 11 ^¹, ²
N-acetyltransferase 11 (GCN5-related, putative) ^²

External Ids
HGNC: 25845¹
Entrez Gene: 79829²
UniProtKB: Q86UY6³
Ensembl: ENSG00000110583⁷

Search outside databases for aliases for NAT11 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAT11 gene

Entrez Gene cytogenetic band: 11q13.1 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

NAT11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P063464: (about GC identifiers)

Start:	63,463,039 bp from pter
End:	63,481,020 bp from pter
Size:	17,982 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033903.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAT11_HUMAN, Q86UY6 (See protein sequence)

Recommended Name: N-acetyltransferase 11

Size: 237 amino acids; 27194 Da

Secondary accessions: Q5HYL5 Q9H897

Alternative splicing: 2 isoforms: Q86UY6-1 Q86UY6-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079047.2

ENSEMBL proteins:

ENSP00000339193 ENSP00000367024

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (NAT11)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for NAT11:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for NAT11

Assays for NAT11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q86UY6

ProtoNet protein and cluster: Q86UY6

1 Blocks protein family: IPB000182 GCN5-related N-acetyltransferase

UniProtKB/Swiss-Prot: NAT11_HUMAN, Q86UY6

Similarity: Belongs to the acetyltransferase family. GNAT subfamily

Similarity: Contains 1 N-acetyltransferase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT11)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024771

Applied Biosystems Silencer® siRNAs for NAT11

Sigma-Aldrich siRNA for NAT11

Sigma-Aldrich shRNA for NAT11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAT11
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_024771
Myc/DDK tagged cDNA clone in CMV expression vector: NM_024771
untagged cDNA clone in CMV expression vector: NM_024771

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024771

1 MGI phenotypic allele

for Nat11 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008080	N-acetyltransferase activity	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT11

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT11)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024771

Sigma-Aldrich siRNA for NAT11

Sigma-Aldrich shRNA for NAT11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_024771

REFSEQ mRNAs for NAT11 gene:

NM_024771.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_024771

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024771
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_024771
                                 untagged cDNA clone in CMV expression vector: NM_024771

Additional cDNA sequence:

AK023910.1 AK299041.1 AK300451.1 AK303557.1 BC024160.2 BC041617.1 BC052298.1 BX647309.1

7 DOTS entries:

DT.425052 DT.434455 DT.100784383 DT.100784384 DT.120727791 DT.430191 DT.95123746

24/134 AceView cDNA sequences (see all 134 ):

BM020459 AA308371 BQ061970 BQ642457 BC052298 BM836913 BG687609 AI365998

BM823419 AU130059 BF184781 AU124159 BM827572 BQ057333 BQ643116 BC041617

BE206497 BQ672790 BV188178 AW130035 AI689228 BM467370 AW978473 BX485764

highest scoring ESTs for NAT11:

AI703239 R72690 AA206783 AA206952 AA308371 AA356451 AA367350 AA652872 AA679971 AA830551

Unigene Cluster for NAT11:

N-acetyltransferase 11 (GCN5-related, putative)

Hs.523753 [show with all ESTs]

Unigene Representative Sequence: BX647309

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NAT11 (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:											-		-		-				-						-
SP2:																			-						-
SP3:											-		-		-				-
SP4:											-								-		-		-		-		-
SP5:											-		-		-				-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for NAT11

2 Ensembl transcripts including schematic representations:

ENST00000338447 ENST00000377793

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAT11

¹ / ² / ³

4 probe-sets matching NAT11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
90329_at²^{, 3}	U95-E	1	1.00	1.00	0.88	1.31	R72690	1.00	1.00	1.00	1
75147_at²^{, 3}	U95-E	1	1.00	1.00	0.88	0.70	AI703239	1.00	1.00	1.00	1
218734_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024771	0.60	1.00	0.82	1
218734_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAT11 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAAAAGCCC

SOURCE GeneReport for Unigene cluster: Hs.523753

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAT11 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	NAT11¹	--	N-acetyltransferase 11 (GCN5-related, putative)	99.58(n) 99.58(a)	466645 XM_522044.2 XP_522044.2
cow (Bos taurus)	NAT11¹	--	N-acetyltransferase 11 (GCN5-related, putative)	91.84(n) 97.89(a)	517933 XM_596114.3 XP_596114.3
rat (Rattus norvegicus)	Nat11¹	--	N-acetyltransferase 11	91.56(n) 97.47(a)	361718 XM_342008.3 XP_342009.3
mouse (Mus musculus)	Nat11^{1, 5}	19⁵	N-acetyltransferase 11^{1, 5}	91.28(n)¹ 98.31(a)¹	70999¹ XM_001473047.1¹ XP_001473097.1¹ AA474384⁵ AK016504⁵ (see all 35)
zebrafish (Danio rerio)	nat11¹	--	N-acetyltransferase 11	74.86(n) 84.32(a)	550325 NM_001017632.1 NP_001017632.1

About this table Species with no ortholog for NAT11

ENSEMBL Gene Tree for NAT11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/150 NCBI SNPs in NAT11 are shown (see all 150 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1386346^1,2	A,C,F,H,O	63479857(-)	`CTTTTT/CTTCCC`	1	--	ut3¹ trp³		8	EU EA WA NA	726
--	rs10897466^1,2	A,C,F,H	63479814(+)	`GAACTA/GATGCT`	1	--	ut3¹ ese³		7	NA EU EA WA	554
	rs10897465^1,2	A,C,F,H	63479024(+)	`GCTTGC/TGCAGT`	1	--	ut3¹ ese³		8	EU EA WA	838
	rs320127^1,2	C,F,H	63480521(-)	`CCACGC/TATCCA`	1	--	ut3¹ ese³		15	EA NA MN EU WA	1226
--	rs1055933^1,2	A,C,F	63480751(+)	`agtgcG/Agtggc`	1	--	ut3¹ ese³		1	MN	184
	rs12284291^1,2	C,F,H	63479240(+)	`TGATTG/TCTTCT`	1	--	ut3¹ ese³		4	EU EA WA	404
	rs7111805^1,2	C,H	63476881(+)	`CATGGC/TCAACA`	1	A/V	mis¹ ese³		5	EU EA WA	588
--	rs7111130^1,2	A,C	63461393(+)	`acaggC/Tgcccg`	1	--	ng5¹		1	EA	172
	rs873928^1,2	F	63463050(+)	`GGGCCG/CTCCGC`	1	--	ut5¹ ese³		1	MN	184
--	rs1059205^1,2	F	63481245(+)	`TGataT/Catata`	1	--	ng3¹		1	MN	184

About this table

HapMap Linkage Disequilibrium images for NAT11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

6 PubMed articles for NAT11 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)³ Fu G.K....Stuve L.L. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79829	HGNC: 25845	AceView: FLJ13848	Ensembl:ENSG00000110583	euGenes: HUgn79829
ECgene: NAT11	H-InvDB: NAT11

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NAT11
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAT11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAT11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAT11		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAT11		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAT11)
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for NAT11

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for NAT11

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NAT11 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for NAT11

Summaries
for NAT11

Genomic Location
for NAT11

Proteins
for NAT11

Protein Domains/
Families
for NAT11

Gene Function
for NAT11

Pathways & Interactions
for NAT11

Drugs & Compounds
for NAT11

Transcripts
for NAT11

Expression
for NAT11

Orthologs
for NAT11

Paralogs
for NAT11

SNPs/Variants
for NAT11

Disorders & Mutations
for NAT11

Medical News
for NAT11

Publications
for NAT11

Search for NAT11

Genome Databases showing NAT11

Other Databases showing NAT11

Specialized Databases showing NAT11

Licensable Technologies
for NAT11

Services
for NAT11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAT11 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor NAT11

Summariesfor NAT11

Genomic Locationfor NAT11

Proteinsfor NAT11

Protein Domains/Familiesfor NAT11

Gene Functionfor NAT11

Pathways & Interactionsfor NAT11

Drugs & Compoundsfor NAT11

Transcriptsfor NAT11

Expression for NAT11

Orthologsfor NAT11

Paralogsfor NAT11

SNPs/Variantsfor NAT11

Disorders & Mutationsfor NAT11

Medical Newsfor NAT11

Publicationsfor NAT11

Search for NAT11

Genome Databases showing NAT11

Other Databases showing NAT11

Specialized Databases showing NAT11

Licensable Technologiesfor NAT11

Servicesfor NAT11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAT11

Summaries
for NAT11

Genomic Location
for NAT11

Proteins
for NAT11

Protein Domains/
Families
for NAT11

Gene Function
for NAT11

Pathways & Interactions
for NAT11

Drugs & Compounds
for NAT11

Transcripts
for NAT11

Expression
for NAT11

Orthologs
for NAT11

Paralogs
for NAT11

SNPs/Variants
for NAT11

Disorders & Mutations
for NAT11

Medical News
for NAT11

Publications
for NAT11

Licensable Technologies
for NAT11

Services
for NAT11