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Aliases & Descriptions for NAT10
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ALP 2 , 3 DKFZp434C116 2 EC 2.3.1.- 3 FLJ10774 1 , 2 FLJ12179 1 , 2 FLJ23850 2 KIAA1709 2 , 3 hALP 1
Descriptions N-acetyltransferase 10 1 , 2 N-acetyltransferase 10 (GCN5-related) 2 N-acetyltransferase-like protein 2
Search outside databases for aliases for NAT10 gene
Summaries for NAT10 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 Function : Has a histone acetyltransferase in vitro. Involved in TERT transactivation
Gene Wiki entry for NAT10
Genomic Location for NAT10
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the NAT10 gene Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p13 NAT10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P034084:
(about GC identifiers )
Start:
34,083,725 bp from pter
End:
34,125,033 bp from pter
Size:
41,309 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000011.8 NT_009237.17 Proteins for NAT10
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 (See
protein sequence )Recommended Name: N-acetyltransferase 10 Size : 1025 amino acids; 115704 Da
Subcellular location : Nucleus, nucleolus
Sequence caution : Sequence=AAO49126.1; Type=Frameshift; Positions=981;
Secondary accessions : Q86WK5 Q9C0F4 Q9HA61 Q9NVF2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001137502.1 NP_078938.2 ENSEMBL proteins: ENSP00000257829 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for NAT10: Assays for NAT10:
Protein
Domains/ Families for NAT10(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9H0A0 ProtoNet protein and cluster: Q9H0A0
2 Blocks protein families : IPB007807 Putative ATPase DUF699 IPB013562 Domain of unknown function DUF1726 UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 Similarity : Belongs to the UPF0202 familySimilarity : Contains 1 N-acetyltransferase domain
Gene Function for NAT10
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_024662 Applied Biosystems Silencer ® siRNAs for NAT10 Sigma-Aldrich siRNA and siRNA Panels for NAT10 Sigma-Aldrich shRNA for NAT10 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144030                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144030                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001144030  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024662 UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 Function : Has a histone acetyltransferase in vitro. Involved in TERT transactivationEnzyme Number (IUBMB): EC 2.3.1.-
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
):
About this table
Pathways & Interactions for NAT10
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/239 Interacting proteins for NAT10 (ENSP00000257829 3 Q9H0A0 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 239
)About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008152 metabolic process
IEA --
About this table
Drugs & Compounds for NAT10 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for NAT10
Transcripts for NAT10(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_024662 Sigma-Aldrich siRNA and siRNA Panels for NAT10 Sigma-Aldrich shRNA for NAT10 Explore Sigma-Aldrich super-pooled esiRNAs
REFSEQ mRNAs for NAT10 gene (2 alternative transcripts): NM_001144030.1 NM_024662.2
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144030                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001144030                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001144030  
Additional cDNA sequence: AB051496.1 AF489535.1 AK001636.1 AK022241.1 AK225341.1 AK294044.1 AL136882.1 BC014440.1 BC020205.1 BC035558.1
11 DOTS entries : DT.101959418 DT.92445129 DT.115289 DT.97847252 DT.120736894 DT.120737032 DT.95323720 DT.92445113 DT.100777737 DT.97809768 DT.120737005
24/305 AceView cDNA sequences (see all 305
):CD673258 BU189699 AW135110 AL136882 AW664542 CA426736 BC020205 BQ672982 BC035558 BM796420 AW069029 AK022241 BQ014272 BM707981 CF127889 BQ439907 BM747541 BQ672179 CB120897 AW008059 AW023035 NM_024662 BQ649958 AI653416
highest scoring ESTs for NAT10 :AI982834 AA092428 AA132416 AA134161 AA513453 AA548972 AA565825 AA605269 AA617935 AA622401
Unigene Cluster for NAT10: N-acetyltransferase 10 (GCN5-related) Hs.577281 [show with all ESTs ] Unigene Representative Sequence: NM_024662 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 (see all 6
) ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ SP1 :       -   -   -                                           SP2 :       -   -   -   -                                         SP3 :       -   -                                             SP4 :         -                                             SP5 :           -                                          
ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b SP1 :                     -           SP2 :                               SP3 :                               SP4 :                               SP5 :                              
About this scheme ECgene alternative splicing isoforms for NAT10 1 Ensembl transcript including schematic representation : ENST00000257829
Expression for NAT10
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NAT10 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NAT10 1 / 2 / 3
4 probe-sets matching NAT10 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCAGCCCGCGSOURCE GeneReport for Unigene cluster: Hs.577281
Orthologs for NAT10
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NAT10 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for NAT10 ENSEMBL Gene Tree for NAT10 Paralogs for NAT10 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for NAT10 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NAT10 (up to first 250kb)
Disorders & Mutations for NAT10
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 609221
Medical News for NAT10 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for NAT10 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/24 PubMed articles for NAT10 gene (see all 24
): Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. (PubMed id 14592445) 1, 2, 3, 4 Lv J.... Zhang B. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Functional proteomic analysis of human nucleolus. (PubMed id 12429849) 3, 4 Scherl A.... Diaz J.-J. (2002) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970) 3, 4 Nagase T....Ohara O. (2000) DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. (PubMed id 17180247) 1, 3 Liu H....Zhang B. (2007) Structural basis and specificity of human otubain 1-mediated deubiquitination. (PubMed id 18954305) 3 Edelmann M.J....Kessler B.M. (2009) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PubMed id 17631499) 3 Chi Y.H....Jeang K.T. (2007)
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Genome Databases showing NAT10
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing NAT10
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Specialized Databases showing NAT10 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for NAT10 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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