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NAT10 Gene

protein-coding   GIFtS: 57

GC11P034084
N-acetyltransferase 10 (GCN5-related)
(Previous name: N-acetyltransferase 10 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
ALP 2, 3
DKFZp434C116 2
EC 2.3.1.- 3
FLJ10774 1, 2
FLJ12179 1, 2
FLJ23850 2
KIAA1709 2, 3
hALP 1
Descriptions
N-acetyltransferase 10 1, 2
N-acetyltransferase 10 (GCN5-related) 2
N-acetyltransferase-like protein 2
External Ids
HGNC: 298301
Entrez Gene: 552262
UniProtKB: Q9H0A03
Ensembl: ENSG000001353727
Search outside databases for aliases for NAT10 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
Function: Has a histone acetyltransferase in vitro. Involved in TERT transactivation

Gene Wiki entry for NAT10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NAT10 gene  

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

NAT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034084:     (about GC identifiers)

Start:
34,083,725 bp from pter
End:
34,125,033 bp from pter
Size:
41,309 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 (See protein sequence)
Recommended Name: N-acetyltransferase 10  
Size: 1025 amino acids; 115704 Da
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAO49126.1; Type=Frameshift; Positions=981;
Secondary accessions: Q86WK5 Q9C0F4 Q9HA61 Q9NVF2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001137502.1  NP_078938.2  


    ENSEMBL proteins: 
    ENSP00000257829 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (NAT10)
    Human Recombinant Proteins from Abnova (NAT10)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus NAS11214970
    About this table

    Antibodies for NAT10: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (NAT10), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NAT10)
    Novus Biologicals Antibody for NAT10

    Assays for NAT10: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR000182 GCN5-rel_AcTrfase
     IPR007807 DUF699_ATPase
     IPR013562 DUF1726


       GeneDecks  NAT10 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9H0A0

    ProtoNet protein and cluster: Q9H0A0

    2 Blocks protein families:
    IPB007807 Putative ATPase DUF699
    IPB013562 Domain of unknown function DUF1726


    UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
    Similarity: Belongs to the UPF0202 family
    Similarity: Contains 1 N-acetyltransferase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NAT10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NAT10)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024662

                  Applied Biosystems Silencer® siRNAs for NAT10

                  Sigma-Aldrich siRNA and siRNA Panels for NAT10  
                         Sigma-Aldrich shRNA for NAT10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144030
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144030
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001144030 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024662

    UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
    Function: Has a histone acetyltransferase in vitro. Involved in TERT transactivation
    Enzyme Number (IUBMB): EC 2.3.1.- 

    5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003674 molecular_function ND--
    GO:0005515 protein binding IPI17353931
    GO:0005524 ATP binding IEA--
    GO:0008080 N-acetyltransferase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/239 Interacting proteins for NAT10 (ENSP000002578293 Q9H0A01, 2) via UniProtKB, MINT, and/or STRING (see all 239 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LYARQ9NX581EBI-876527, EBI-713507
    ATAD3BQ5T9A42MINT-6488791
    COPAP536212MINT-6488791
    DDX18Q9NVP12MINT-6488791
    DDX39O001482MINT-6488791
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152 metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NAT10

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NAT10)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (NAT10)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024662

                  Sigma-Aldrich siRNA and siRNA Panels for NAT10  
                         Sigma-Aldrich shRNA for NAT10  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    REFSEQ mRNAs for NAT10 gene (2 alternative transcripts): 

    NM_001144030.1   NM_024662.2   


                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001144030
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001144030
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001144030 

    Additional cDNA sequence: 

    AB051496.1 AF489535.1 AK001636.1 AK022241.1 AK225341.1 AK294044.1 AL136882.1 BC014440.1 
    BC020205.1 BC035558.1 

    11 DOTS entries:

    DT.101959418  DT.92445129  DT.115289  DT.97847252  DT.120736894  DT.120737032  DT.95323720  DT.92445113 
    DT.100777737  DT.97809768  DT.120737005 

    24/305 AceView cDNA sequences (see all 305 ):

    CD673258 BU189699 AW135110 AL136882 AW664542 CA426736 BC020205 BQ672982 
    BC035558 BM796420 AW069029 AK022241 BQ014272 BM707981 CF127889 BQ439907 
    BM747541 BQ672179 CB120897 AW008059 AW023035 NM_024662 BQ649958 AI653416 

    highest scoring ESTs for NAT10:

    AI982834 AA092428 AA132416 AA134161 AA513453 AA548972 AA565825 AA605269 AA617935 AA622401 

    Unigene Cluster for NAT10:

    N-acetyltransferase 10 (GCN5-related)
    Hs.577281  [show with all ESTs]
    Unigene Representative Sequence: NM_024662


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 (see all 6 )

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -     -                                                                                                                           
    SP2:                    -     -     -     -                                                                                                                     
    SP3:                    -     -                                                                                                                                 
    SP4:                          -                                                                                                                                 
    SP5:                                -                                                                                                                           

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
    SP1:                                                              -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for NAT10

    1 Ensembl transcript including schematic representation:
    ENST00000257829  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NAT10 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NAT10

    1 / 2 / 3

    4 probe-sets matching NAT10 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    43161_at2, 3 U95-B 1 1.00 1.00 0.86 0.83 AI982834 1.00 1.00 1.00 1

    46251_at2, 3 U95-B 1 1.00 1.00 0.66 1.17 AA632288 0.80 1.00 0.91 1

    217884_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024662 0.60 1.00 0.82 1

    217884_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCAGCCCGCG

    SOURCE GeneReport for Unigene cluster: Hs.577281
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for NAT10 gene from 5/19 species (see all 19 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NAT101   -- N-acetyltransferase 10 (GCN5-related) 90.2(n)
    95.21(a)
    483431  XM_852932.1  XP_858025.1 
    chimpanzee
    (Pan troglodytes)
    NAT101   -- N-acetyltransferase 10 (GCN5-related) 96.74(n)
    96.58(a)
    466485  XM_001146522.1  XP_001146522.1 
    cow
    (Bos taurus)
    NAT101   -- N-acetyltransferase 10 (GCN5-related) 91.02(n)
    96.39(a)
    515001  XM_865490.2  XP_870583.1 
    mouse
    (Mus musculus)
    Nat101, 5 25
    N-acetyltransferase 101, 5 88.83(n)1
    95.41(a)1
    989561  NM_153126.21  NP_694766.11 
     AA7949015  AI4291525  (see all 23)
    chicken
    (Gallus gallus)
    NAT101   -- N-acetyltransferase 10 77.79(n)
    87.63(a)
    426609  NM_001012940.1  NP_001012958.1 
    About this table        Species with no ortholog for NAT10

    ENSEMBL Gene Tree for NAT10
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/202 NCBI SNPs in NAT10 are shown (see all 202 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 107)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs81871,2
    A,C,F,H,O34124729(-) AGACCC/TAGCGG 1 -- ut31 ese318Minor allele frequency- T:0.22NS MN EU EA WA NA 1338
    rs18839581,2
    C,F,H,O34083698(-) GAGAAG/CGGACC 1 -- ng517Minor allele frequency- C:0.03EU EA WA NA 558
    rs29574861,2
    C,F,H34082887(-) AAGCAA/GAAGTA 1 -- ng514Minor allele frequency- G:0.01EU EA WA 420
    rs29575161,2
    C,H34109515(+) CACTGC/TATGAG 1 H/Y mis14Minor allele frequency- T:0.00EU EA WA 418
    rs169251701,2
    F,H34082746(+) TGGCAC/TGGGGA 1 -- ng517Minor allele frequency- T:0.09NA EU EA WA 560
    rs19836421,2
    F,H34124401(-) CTCTCG/CTTGCT 1 -- ut31 ese34Minor allele frequency- C:0.01EU EA WA 418
    rs169251731,2
    F,H34083109(+) TCCAGG/CAGGAA 1 -- ng517Minor allele frequency- C:0.09NA EU EA WA 562
    rs128033031,2
    H34083323(+) TTCCCA/GTCTGT 1 -- ng514Minor allele frequency- G:0.00EU EA WA 412
    rs122258061,2
    H34124975(+) TGCTCG/ACAGGG 1 -- ut31 ese34Minor allele frequency- A:0.00EU EA WA 418
    rs110325141,2
    H34082916(+) ACCTAG/AAATTA 1 -- ng51 tfbs34Minor allele frequency- A:0.00EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for NAT10 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609221

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/24 PubMed articles for NAT10 gene (see all 24 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55226 HGNC: 29830 AceView: FLJ10774 Ensembl:ENSG00000135372 euGenes: HUgn55226
    ECgene: NAT10 H-InvDB: NAT10
    (According to HUGE)
    About This Section

    HUGE: KIAA1709
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NAT10:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for NAT10-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for NAT10 Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NAT10 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Search OriGene for NAT10
     Search Tocris compounds for NAT10




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for NAT10

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