Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NAT10 Gene

protein-coding   GIFtS: 59
GCID: GC11P034084

N-Acetyltransferase 10 (GCN5-Related)

(Previous name: N-acetyltransferase 10)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
N-Acetyltransferase 10 (GCN5-Related)1 2     N-Acetyltransferase-Like Protein2
N-Acetyltransferase 101 2     EC 2.3.1.-3
ALP2 3     KIAA17093
NET432     

External Ids:    HGNC: 298301   Entrez Gene: 552262   Ensembl: ENSG000001353727   OMIM: 6092215   UniProtKB: Q9H0A03   

Export aliases for NAT10 gene to outside databases

Previous GC identifer: GC11P033823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NAT10 Gene:
NAT10 (N-acetyltransferase 10 (GCN5-related)) is a protein-coding gene. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
Function: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone
acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by
stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of
telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect
microtubule stability and cell division

Gene Wiki entry for NAT10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAT10 gene promoter:
         Max1   USF1   AML1a   Nkx2-5   LCR-F1   C/EBPalpha   AREB6   CHOP-10   S8   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NAT10 promoter sequence
   Search Chromatin IP Primers for NAT10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

NAT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034084:  view genomic region     (about GC identifiers)

Start:
34,127,111 bp from pter      End:
34,169,217 bp from pter
Size:
42,107 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 (See protein sequence)
Recommended Name: N-acetyltransferase 10  
Size: 1025 amino acids; 115730 Da
Subunit: Interacts with SUN1 (via N-terminus). Also interacts with TERT
Sequence caution: Sequence=AAO49126.1; Type=Frameshift; Positions=981; Sequence=BAB21800.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q86WK5 Q9C0F4 Q9HA61 Q9NVF2

Explore the universe of human proteins at neXtProt for NAT10: NX_Q9H0A0

Explore proteomics data for NAT10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys904, Lys956
  • Modification sites at PhosphoSitePlus

  • See NAT10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137502.1  NP_078938.2  

    ENSEMBL proteins: 
     ENSP00000257829   ENSP00000433011   ENSP00000435569   ENSP00000437324  

    NAT10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NAT10
    OriGene Protein Over-expression Lysate for NAT10
    OriGene MassSpec for NAT10
    OriGene Custom Protein Services for NAT10
    GenScript Custom Purified and Recombinant Proteins Services for NAT10
    Novus Biologicals NAT10 Proteins
    Novus Biologicals NAT10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NAT10

     
    Search eBioscience for Proteins for NAT10 

     
    antibodies-online proteins for NAT10 (3 products) 

     
    Search antibodies-online for peptides for NAT10

    NAT10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NAT10
    OriGene Custom Antibody Services for NAT10
    Novus Biologicals NAT10 Antibodies
    Abcam antibodies for NAT10
    Cloud-Clone Corp. Antibodies for NAT10
    ThermoFisher Antibody for NAT10
    antibodies-online antibodies for NAT10 (25 products) 

    NAT10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAT10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAT10
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAT10
    Cloud-Clone Corp. CLIAs for NAT10
    Search eBioscience for ELISAs for NAT10 
    antibodies-online kits for NAT10 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR027992 tRNA_bind_dom
     IPR013562 DUF1726
     IPR000182 GNAT_dom
     IPR007807 Helicase_dom
     IPR016181 Acyl_CoA_acyltransferase

    Graphical View of Domain Structure for InterPro Entry Q9H0A0

    ProtoNet protein and cluster: Q9H0A0

    2 Blocks protein domains:
    IPB007807 Putative ATPase DUF699
    IPB013562 Domain of unknown function DUF1726


    UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
    Similarity: Belongs to the UPF0202 family
    Similarity: Contains 1 N-acetyltransferase domain


    Find genes that share domains with NAT10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAT10_HUMAN, Q9H0A0
    Function: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone
    acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by
    stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of
    telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect
    microtubule stability and cell division
    Induction: Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular
    resistance to genotoxic agents

         Enzyme Number (IUBMB): EC 2.3.1.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005524ATP binding IEA--
    GO:0008080N-acetyltransferase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with NAT10           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Nat10):
     mortality/aging 

    Find genes that share phenotypes with NAT10           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NAT10

    miRNA
    Products:
        
    miRTarBase miRNAs that target NAT10:
    hsa-mir-375 (MIRT019738), hsa-mir-149-5p (MIRT045635)

    Block miRNA regulation of human, mouse, rat NAT10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NAT10:
    hsa-miR-4314 hsa-miR-376a* hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAT10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAT10
    Predesigned siRNA for gene silencing in human, mouse, rat NAT10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAT10

    Clone
    Products:
         
    OriGene clones in human, mouse for NAT10 (see all 13)
    OriGene ORF clones in mouse, rat for NAT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NAT10 (NM_024662)
    Sino Biological Human cDNA Clone for NAT10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NAT10
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAT10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NAT10_HUMAN, Q9H0A0: Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal
    layer and to the midbody during telophase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11214970
    GO:0005730nucleolus IEA--

    Find genes that share ontologies with NAT10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NAT10 About    
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    metapathway biotransformation0.42
    2Ribosome biogenesis in eukaryotes
    Ribosome biogenesis in eukaryotes


    Find genes that share SuperPaths with NAT10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NAT10
        metapathway biotransformation



    1 Kegg Pathway  (Kegg details for NAT10):
        Ribosome biogenesis in eukaryotes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAT10
    Interactions:

        Search GeneGlobe Interaction Network for NAT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAT10 (Q9H0A01, 2, 3 ENSP000002578294) via UniProtKB, MINT, STRING, and/or I2D (see all 1039)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4FP628053, ENSP000003669744I2D: score=5 STRING: ENSP00000366974
    HIST1H4HP628053, ENSP000002893524I2D: score=5 STRING: ENSP00000289352
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with NAT10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAT10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NAT10 gene (2 alternative transcripts): 
    NM_001144030.1  NM_024662.2  

    Unigene Cluster for NAT10:

    N-acetyltransferase 10 (GCN5-related)
    Hs.577281  [show with all ESTs]
    Unigene Representative Sequence: NM_024662
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257829(uc001mvk.3 uc010ren.2) ENST00000532503 ENST00000531159
    ENST00000531723 ENST00000529523 ENST00000527971 ENST00000530017 ENST00000532555
    ENST00000534509
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAT10 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NAT10:
    hsa-miR-4314 hsa-miR-376a* hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAT10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAT10
    Predesigned siRNA for gene silencing in human, mouse, rat NAT10
    Clone
    Products:
         
    OriGene clones in human, mouse for NAT10 (see all 13)
    OriGene ORF clones in mouse, rat for NAT10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NAT10 (NM_024662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAT10
    OriGene qSTAR qPCR primer pairs in human, mouse for NAT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT10
      QuantiTect SYBR Green Assays in human, mouse, rat NAT10
      QuantiFast Probe-based Assays in human, mouse, rat NAT10

    Additional mRNA sequence: 

    AB051496.1 AF489535.1 AK001636.1 AK022241.1 AK225341.1 AK294044.1 AL136882.1 BC014440.1 
    BC020205.1 BC035558.1 

    14 DOTS entries:

    DT.101959418  DT.92445129  DT.115289  DT.97847252  DT.120736894  DT.120737032  DT.95323720  DT.100877964 
    DT.92445113  DT.100777737  DT.97809768  DT.120737005  DT.95157379  DT.87017561 

    Selected AceView cDNA sequences (see all 305):

    AI366661 AI265783 BX386648 BI090035 AA227336 AW135110 CD673258 AI348128 
    BX106679 BQ892694 NM_024662 AK001636 CA312348 AI861869 BQ439907 AI081970 
    AW294433 AI337342 CB120897 AI275563 AL136882 BI222602 BQ672982 BU162185 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -     -                                                                                                                           
    SP2:                    -     -     -     -                                                                                                                     
    SP3:                    -     -                                                                                                                                 
    SP4:                          -                                                                                                                                 
    SP5:                                -                                                                                                                           

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
    SP1:                                                              -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NAT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NAT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCCCGCG
    NAT10 Expression
    About this image


    NAT10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Rostral Skull Membranous Bones
     
     Limb (Muscoskeletal System)
             Pelvic Girdle
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    NAT10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAT10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.577281
        Custom PCR Arrays for NAT10
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NAT10
    OriGene qSTAR qPCR primer pairs in human, mouse for NAT10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT10
    QuantiTect SYBR Green Assays in human, mouse, rat NAT10
    QuantiFast Probe-based Assays in human, mouse, rat NAT10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAT10 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nat101 , 5 N-acetyltransferase 101, 5 88.88(n)1
    95.66(a)1
      2 (54.43 cM)5
    989561  NM_153126.21  NP_694766.11 
     1037212565 
    chicken
    (Gallus gallus)
    Aves NAT101 N-acetyltransferase 10 (GCN5-related) 77.84(n)
    88.1(a)
      426609  NM_001012940.1  NP_001012958.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAT106
    N-acetyltransferase 10 (GCN5-related)
    86(a)
    1 ↔ 1
    GL343283.1(1167396-1198491)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137352 Xenopus laevis transcribed sequence with moderate similarity more 77.55(n)    CF285263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc661192 hypothetical protein MGC66119 76.78(n)   393617  BC057462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)G00201 lethal (1) G0020 57.28(n)
    54.8(a)
      31811  NM_132275.1  NP_572503.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nath-101 nath-10 55.92(n)
    56.99(a)
      172182  NM_059173.4  NP_491574.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes KRE33(YNL132W)4
    KRE331
    Essential protein, required for biogenesis of the small more4
    KRE331
    55.61(n)1
    58.27(a)1
      14(375321-378491)4
    8555911, 4  NP_014267.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G104901 AT1G10490 54.95(n)
    53.79(a)
      837589  NM_100923.3  NP_172519.1 
    rice
    (Oryza sativa)
    Liliopsida Os.102952 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.26(n)    AK058272.1 


    ENSEMBL Gene Tree for NAT10 (if available)
    TreeFam Gene Tree for NAT10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NAT10 (see all 1118)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452043731,2
    --34053867(+) AAAGTA/TGCCAG 2 -- us2k10--------
    rs1476162251,2
    --34053874(+) CCAGGC/TGTTGT 2 -- us2k10--------
    rs1874343591,2
    C--34053938(+) GAACCC/TGGGAA 2 -- us2k10--------
    rs1114362981,2
    C,F--34053973(+) CGCGCC/TACTGC 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1898651301,2
    --34053991(+) CCTGGA/GCGACA 2 -- us2k10--------
    rs1816779621,2
    --34053992(+) CTGGGC/TGACAG 2 -- us2k10--------
    rs1862169741,2
    --34054162(+) AGGAGA/GCTTGT 2 -- us2k10--------
    rs128081261,2
    H--34054185(+) TGTGAG/AAAATG 2 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs783582791,2
    C,F--34054241(+) CTATGG/AATTCC 2 -- us2k12Minor allele frequency- A:0.03NA 122
    rs735010461,2
    C,F--34054246(+) GATTCG/CCTATC 2 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for NAT10 (34127111 - 34169217 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NAT10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509400CNV Insertion20534489

    Human Gene Mutation Database (HGMD): NAT10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAT10
    DNA2.0 Custom Variant and Variant Library Synthesis for NAT10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609221    OMIM disorders: --


    Find genes that share disorders with NAT10           About GenesLikeMe


    Export disorders for NAT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NAT10 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with NAT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. (PubMed id 14592445)1, 2, 3, 9 Lv J.... Zhang B. (Biochem. Biophys. Res. Commun. 2003)
    2. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. (PubMed id 19303003)1, 2, 9 Shen Q.... Zhang B. (Exp. Cell Res. 2009)
    3. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. (PubMed id 17180247)1, 2, 9 Liu H.... Zhang B. (Mol. Cell. Biochem. 2007)
    4. hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF). (PubMed id 21177859)1, 3 Kong R....Ke Y. (J. Biol. Chem. 2011)
    5. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. (PubMed id 18082603)1, 2 Fu D. and Collins K. (Mol. Cell 2007)
    6. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PubMed id 17631499)1, 2 Chi Y.-H.... Jeang K.-T. (J. Biol. Chem. 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (Mol. Biol. Cell 2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55226 HGNC: 29830 AceView: FLJ10774 Ensembl:ENSG00000135372 euGenes: HUgn55226
    ECgene: NAT10 Kegg: 55226 H-InvDB: NAT10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1709

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NAT10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NAT10 gene:
    Search GeneIP for patents involving NAT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NAT10   OriGene RNAi products in human, mouse, rat for NAT10  
     OriGene qPCR primer pairs and template standards for NAT10   OriGene Protein Over-expression Lysate for NAT10  
     OriGene MassSpec for NAT10   OriGene clones in human, mouse for NAT10  
     OriGene qSTAR qPCR primer pairs in human, mouse for NAT10   OriGene Purified Protein for NAT10  
     OriGene ORF clones in mouse, rat for NAT10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NAT10   OriGene Custom Protein Services for NAT10  

     
     
     Block miRNA regulation of human, mouse, rat NAT10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NAT10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAT10 Predesigned siRNA for gene silencing in human, mouse, rat NAT10
     QuantiFast Probe-based Assays in human, mouse, rat NAT10 QuantiTect SYBR Green Assays in human, mouse, rat NAT10
     Custom PCR Arrays for NAT10 Search Chromatin IP Primers for NAT10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT10  Search GeneGlobe Interaction Network for NAT10
     Regulatory tfbs in NAT10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NAT10 GenScript cDNA clones with any tag delivered in your preferred vector for NAT10
     GenScript Custom Assay Services for NAT10 GenScript Custom overexpressing Cell Line Services for NAT10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NAT10
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NAT10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NAT10 antibodies
     NAT10 proteins
     NAT10 lysates
     Antibodies for NAT10
     See all of Abcam's Antibodies, Kits and Proteins for NAT10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NAT10
     Antibodies for NAT10
     ELISAs for NAT10
     CLIAs for NAT10



     Browse ESI BIO Cell Lines and PureStem Progenitors for NAT10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT10
     SwitchGear 3'UTR luciferase reporter plasmids for NAT10
     SwitchGear Promoter luciferase reporter plasmids for NAT10
     ThermoFisher Antibody for NAT10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT10
     Browse compounds at ApexBio
     Search Addgene for plasmids for NAT10
      Search eBioscience for proteins for NAT10
      Search eBioscience for elisas for NAT10
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for NAT10
     antibodies-online antibodies for NAT10 (25 products)
     antibodies-online kits for NAT10 (4 products)
      Search antibodies-online for peptides for NAT10
     antibodies-online proteins for NAT10 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NAT10 gene at Home site.
    Version: 3.12.264 25 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4