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Aliases for NAT10 Gene

Aliases for NAT10 Gene

  • N-Acetyltransferase 10 2 3 4 5
  • N-Acetyltransferase 10 (GCN5-Related) 2 3
  • 18S RRNA Cytosine Acetyltransferase 3 4
  • ALP 3 4
  • N-Acetyltransferase-Like Protein 3
  • RNA Cytidine Acetyltransferase 3
  • EC 2.3.1.- 4
  • KIAA1709 4
  • NET43 3

External Ids for NAT10 Gene

Previous GeneCards Identifiers for NAT10 Gene

  • GC11P033823

Summaries for NAT10 Gene

Entrez Gene Summary for NAT10 Gene

  • The protein encoded by this gene is an RNA cytidine acetyltransferase involved in histone acetylation, tRNA acetylation, the biosynthesis of 18S rRNA, and the enhancement of nuclear architecture and chromatin organization. [provided by RefSeq, Oct 2016]

GeneCards Summary for NAT10 Gene

NAT10 (N-Acetyltransferase 10) is a Protein Coding gene. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT10 Gene

  • RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).

Gene Wiki entry for NAT10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT10 Gene

Genomics for NAT10 Gene

Regulatory Elements for NAT10 Gene

Enhancers for NAT10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G034103 1.7 FANTOM5 ENCODE dbSUPER 20.4 -0.1 -145 3.2 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 NAT10 CAPRIN1 CSTF3 ABTB2 GC11P034062
GH11G034213 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +109.0 108976 2.3 FOXA2 MLX ARID4B FEZF1 DMAP1 TCF12 GTF3C2 ZNF121 GATA2 ELK1 ABTB2 NAT10 PIR39921 GC11M034177
GH11G034652 2 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +548.8 548841 4.3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS EHF APIP FBXO3 NAT10 CD44 ABTB2 ELF5 NDUFB8P3
GH11G034233 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +128.8 128797 1.0 HDGF PKNOX1 TBL1XR1 KLF17 ELK1 SMARCC2 FOS RELB ETV6 IKZF2 FBXO3 NAT10 ABTB2 LMO2 PIR39921 GC11M034177
GH11G033630 1.2 ENCODE dbSUPER 15.1 -471.4 -471448 6.8 TBP PKNOX1 SIN3A RAD21 RARA RFX5 GTF3C2 ZSCAN5C FOS SMARCC1 NAT10 KIAA1549L LOC105376617 GC11M033594 PIR36412
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAT10 on UCSC Golden Path with GeneCards custom track

Promoters for NAT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000038633 236 1601 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1

Genomic Location for NAT10 Gene

Chromosome:
11
Start:
34,105,564 bp from pter
End:
34,151,034 bp from pter
Size:
45,471 bases
Orientation:
Plus strand

Genomic View for NAT10 Gene

Genes around NAT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT10 Gene

Proteins for NAT10 Gene

  • Protein details for NAT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0A0-NAT10_HUMAN
    Recommended name:
    RNA cytidine acetyltransferase
    Protein Accession:
    Q9H0A0
    Secondary Accessions:
    • B4DFD5
    • E7ESU4
    • E9PMN9
    • Q86WK5
    • Q9C0F4
    • Q9HA61
    • Q9NVF2

    Protein attributes for NAT10 Gene

    Size:
    1025 amino acids
    Molecular mass:
    115730 Da
    Quaternary structure:
    • Interacts with THUMBD1 (PubMed:25653167). Interacts with SUN1 (via N-terminus) (PubMed:17631499). Interacts with TERT (PubMed:18082603).
    SequenceCaution:
    • Sequence=AAO49126.1; Type=Frameshift; Positions=981; Evidence={ECO:0000305}; Sequence=BAB21800.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NAT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT10 Gene

Post-translational modifications for NAT10 Gene

  • Ubiquitination at Lys904 and posLast=956956
  • Modification sites at PhosphoSitePlus

Other Protein References for NAT10 Gene

No data available for DME Specific Peptides for NAT10 Gene

Domains & Families for NAT10 Gene

Gene Families for NAT10 Gene

Suggested Antigen Peptide Sequences for NAT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0A0

UniProtKB/Swiss-Prot:

NAT10_HUMAN :
  • Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
Family:
  • Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.
genes like me logo Genes that share domains with NAT10: view

Function for NAT10 Gene

Molecular function for NAT10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A cytidine in 18S rRNA + ATP + acetyl-CoA + H(2)O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA.
UniProtKB/Swiss-Prot CatalyticActivity:
A cytidine in tRNA + ATP + acetyl-CoA + H(2)O = an N(4)-acetylcytidine in tRNAA + ADP + phosphate + CoA.
UniProtKB/Swiss-Prot Function:
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs (PubMed:25653167). Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis (PubMed:25653167). Catalyzes the formation of ac4C in serine and leucine tRNAs (By similarity). Requires the tRNA-binding adapter protein THUMBD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (PubMed:25653167). Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division (PubMed:14592445, PubMed:17631499, PubMed:18082603, PubMed:19303003).
UniProtKB/Swiss-Prot Induction:
Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular resistance to genotoxic agents.

Enzyme Numbers (IUBMB) for NAT10 Gene

Gene Ontology (GO) - Molecular Function for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IBA --
GO:0000166 nucleotide binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25653167
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NAT10: view
genes like me logo Genes that share phenotypes with NAT10: view

Animal Models for NAT10 Gene

MGI Knock Outs for NAT10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NAT10

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAT10 Gene

Localization for NAT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT10 Gene

Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase. {ECO:0000269 PubMed:19303003}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAT10 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 nuclear chromosome, telomeric region IDA 19135898
GO:0005634 nucleus NAS,IEA 11214970
GO:0005654 nucleoplasm TAS --
GO:0005697 colocalizes_with telomerase holoenzyme complex IDA 18082603
GO:0005730 nucleolus IEA,IDA 18082603
genes like me logo Genes that share ontologies with NAT10: view

Pathways & Interactions for NAT10 Gene

genes like me logo Genes that share pathways with NAT10: view

Pathways by source for NAT10 Gene

Gene Ontology (GO) - Biological Process for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000154 rRNA modification IEA,TAS --
GO:0002101 tRNA wobble cytosine modification IBA --
GO:0006364 rRNA processing IEA --
GO:0008033 tRNA processing IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with NAT10: view

No data available for SIGNOR curated interactions for NAT10 Gene

Drugs & Compounds for NAT10 Gene

(1) Drugs for NAT10 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Remodelin Pharma 0

(1) ApexBio Compounds for NAT10 Gene

Compound Action Cas Number
Remodelin 1622921-15-6
genes like me logo Genes that share compounds with NAT10: view

Transcripts for NAT10 Gene

Unigene Clusters for NAT10 Gene

N-acetyltransferase 10 (GCN5-related):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NAT10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -
SP6:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NAT10 Gene

GeneLoc Exon Structure for
NAT10
ECgene alternative splicing isoforms for
NAT10

Expression for NAT10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAT10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.3), Blymphocyte (6.7), Pancreas (6.1), and CD8 Tcells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAT10 Gene



Protein tissue co-expression partners for NAT10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAT10 Gene:

NAT10

SOURCE GeneReport for Unigene cluster for NAT10 Gene:

Hs.577281

Evidence on tissue expression from TISSUES for NAT10 Gene

  • Nervous system(4.9)
  • Blood(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NAT10: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAT10 Gene

Orthologs for NAT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT10 34 35
  • 99.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
-- 35
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NAT10 34 35
  • 91 (n)
dog
(Canis familiaris)
Mammalia NAT10 34 35
  • 90.74 (n)
mouse
(Mus musculus)
Mammalia Nat10 16 35 34
  • 88.88 (n)
oppossum
(Monodelphis domestica)
Mammalia NAT10 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nat10 34
  • 86.16 (n)
chicken
(Gallus gallus)
Aves NAT10 34 35
  • 77.84 (n)
lizard
(Anolis carolinensis)
Reptilia NAT10 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nat10 34
  • 74.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13735 34
zebrafish
(Danio rerio)
Actinopterygii nat10 34 35
  • 73.19 (n)
zgc66119 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010491 34
  • 57.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0020 35 34
  • 57.28 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nath-10 34 35
  • 55.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR346C 34
  • 56.98 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24398g 34
  • 55.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRE33 34 35 37
  • 55.61 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10490 34
  • 54.95 (n)
rice
(Oryza sativa)
Liliopsida Os12g0170700 34
  • 49.86 (n)
Os.10295 34
bread mold
(Neurospora crassa)
Ascomycetes NCU10654 34
  • 57.16 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20G8.09c 34
  • 55.62 (n)
Species where no ortholog for NAT10 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAT10 Gene

ENSEMBL:
Gene Tree for NAT10 (if available)
TreeFam:
Gene Tree for NAT10 (if available)

Paralogs for NAT10 Gene

No data available for Paralogs for NAT10 Gene

Variants for NAT10 Gene

Sequence variations from dbSNP and Humsavar for NAT10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs386352337 Uncertain significance 34,140,404(+) GCCCT(C/G)AGCCG reference, synonymous-codon
rs1000007791 -- 34,126,013(+) GTTGC(C/T)GCCTC intron-variant
rs1000019698 -- 34,114,547(+) CTTCA(C/T)CACTT intron-variant
rs1000205970 -- 34,123,535(+) GAGGG(C/T)GTTGT intron-variant
rs1000252234 -- 34,120,738(+) GACAT(A/G)AGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAT10 Gene

Variant ID Type Subtype PubMed ID
esv3625907 CNV loss 21293372
nsv509400 CNV insertion 20534489
nsv951600 CNV deletion 24416366

Variation tolerance for NAT10 Gene

Residual Variation Intolerance Score: 24.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.36; 63.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAT10 Gene

Human Gene Mutation Database (HGMD)
NAT10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAT10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAT10 Gene

Disorders for NAT10 Gene

Relevant External Links for NAT10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAT10

No disorders were found for NAT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAT10 Gene

Publications for NAT10 Gene

  1. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. (PMID: 14592445) Lv J. … Zhang B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 22 64
  2. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. (PMID: 25653167) Sharma S. … Lafontaine D.L. (Nucleic Acids Res. 2015) 2 3 4 64
  3. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. (PMID: 19303003) Shen Q. … Zhang B. (Exp. Cell Res. 2009) 3 4 22 64
  4. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. (PMID: 17180247) Liu H. … Zhang B. (Mol. Cell. Biochem. 2007) 3 4 22 64
  5. hALP, a novel transcriptional U three protein (t-UTP), activates RNA polymerase I transcription by binding and acetylating the upstream binding factor (UBF). (PMID: 21177859) Kong R. … Ke Y. (J. Biol. Chem. 2011) 2 3 64

Products for NAT10 Gene

Sources for NAT10 Gene

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