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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAT10 Gene

protein-coding   GIFtS: 54
GCID: GC11P034084

N-acetyltransferase 10 (GCN5-related)

(Previous name: N-acetyltransferase 10 )
 Explore 5 diseases affiliated with
NAT10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NAT10    

Aliases
for NAT10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Acetyltransferase 10 (GCN5-Related)1 2     FLJ107741
NET431 2     FLJ121791
N-Acetyltransferase 101 2     HALP1
KIAA17091 3     N-Acetyltransferase-Like Protein2
ALP2 3     EC 2.3.1.-3

External Ids:    HGNC: 298301   Entrez Gene: 552262   Ensembl: ENSG000001353727   OMIM: 6092215   UniProtKB: Q9H0A03   

Export aliases for NAT10 gene to outside databases

Previous GC identifer: GC11P033823


Summaries
for NAT10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
Function: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone
acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by
stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of
telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule
stability and cell division

Gene Wiki entry for NAT10


Genomic Views
for NAT10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAT10 gene promoter:
         Max1   USF1   AML1a   Nkx2-5   LCR-F1   C/EBPalpha   AREB6   CHOP-10   S8   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NAT10 promoter sequence
   Search SABiosciences Chromatin IP Primers for NAT10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p13

NAT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P034084:  view genomic region     (about GC identifiers)

Start:
 34,127,111 bp from pter      End:
 34,169,217 bp from pter
Size:
 42,107 bases      Orientation:
 plus strand

Proteins
for NAT10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0 (See protein sequence)
Recommended Name: N-acetyltransferase 10  
Size: 1025 amino acids; 115730 Da
Subunit: Interacts with SUN1 (via N-terminus). Also interacts with TERT
Subcellular location: Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer
and to the midbody during telophase
Sequence caution: Sequence=AAO49126.1; Type=Frameshift; Positions=981; Sequence=BAB21800.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: Q86WK5 Q9C0F4 Q9HA61 Q9NVF2

Explore the universe of human proteins at neXtProt for NAT10: NX_Q9H0A0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H0A0

    • NAT10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137502.1  NP_078938.2  

    ENSEMBL proteins: 
     ENSP00000257829   ENSP00000433011   ENSP00000435569   ENSP00000437324  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NAT10
    OriGene Protein Over-expression Lysate: NAT10
    OriGene Custom Protein Services for NAT10 
    GenScript Custom Purified and Recombinant Proteins Services for NAT10
    Novus Biologicals NAT10 Proteins
    Novus Biologicals NAT10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NAT10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11214970
    GO:0005730nucleolus IEA--


    NAT10 for ontologies           About GeneDecksing



    NAT10 Antibody Products: 
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    Uscn Antibodies for NAT10
    Search ThermoFisher Antibodies for NAT10

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    Uscn ELISAs and CLIAs for NAT10

    Protein Domains /
    Families
    for NAT10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NAT10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000182 GNAT_dom
     IPR007807 Helicase_dom
     IPR016181 Acyl_CoA_acyltransferase
     IPR013562 DUF1726

    Graphical View of Domain Structure for InterPro Entry Q9H0A0

    ProtoNet protein and cluster: Q9H0A0

    2 Blocks protein families:
    IPB007807 Putative ATPase DUF699
    IPB013562 Domain of unknown function DUF1726


    UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
    Similarity: Belongs to the UPF0202 family
    Similarity: Contains 1 N-acetyltransferase domain


    Function
    for NAT10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAT10_HUMAN, Q9H0A0
    Function: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone
    acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by
    stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of
    telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule
    stability and cell division
    Induction: Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular
    resistance to genotoxic agents

    Enzyme Number (IUBMB): EC 2.3.1.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate NAT10:
    hsa-miR-4314 hsa-miR-376a* hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NAT10 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT10 (see all 7)
    OriGene shRNA RFP: NAT10
    OriGene siRNA: NAT10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT10

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NAT10

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT10 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT10 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NAT10 (NM_024662)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT10 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NAT10
    Search LifeMap BioReagents cell lines for NAT10

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT10

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005524ATP binding IEA--
    GO:0008080N-acetyltransferase activity IEA--


    NAT10 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NAT10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ribosome biogenesis in eukaryotes
    		Ribosome biogenesis in eukaryotes1.00
    2Biological oxidations
    		metapathway biotransformation0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NAT10 
        metapathway biotransformation


    1         Kegg Pathway  (Kegg details for NAT10):
        Ribosome biogenesis in eukaryotes


    NAT10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAT10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/903 Interacting proteins for NAT10 (Q9H0A01, 2, 3 ENSP000002578294) via UniProtKB, MINT, STRING, and/or I2D (see all 903)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    HIST1H4EP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    NAT10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NAT10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAT10
    Search CenterWatch for drugs/clinical trials and news about NAT10 

    Transcripts
    for NAT10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NAT10 gene (2 alternative transcripts): 
    NM_001144030.1  NM_024662.2  

    Unigene Cluster for NAT10:

    N-acetyltransferase 10 (GCN5-related)
    Hs.577281  [show with all ESTs]
    Unigene Representative Sequence: NM_024662
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257829(uc001mvk.3 uc010ren.2) ENST00000532503 ENST00000531159
    ENST00000531723 ENST00000529523 ENST00000527971 ENST00000530017 ENST00000532555
    ENST00000534509

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT10
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate NAT10:
    hsa-miR-4314 hsa-miR-376a* hsa-miR-3121-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NAT10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT10 (see all 7)
    OriGene shRNA RFP: NAT10
    OriGene siRNA: NAT10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT10 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT10 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NAT10 (NM_024662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT10 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAT10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT10

    Additional cDNA sequence: 

    AB051496.1 AF489535.1 AK001636.1 AK022241.1 AK225341.1 AK294044.1 AL136882.1 BC014440.1 
    BC020205.1 BC035558.1 

    14 DOTS entries:

    DT.101959418  DT.92445129  DT.115289  DT.97847252  DT.120736894  DT.120737032  DT.95323720  DT.100877964 
    DT.92445113  DT.100777737  DT.97809768  DT.120737005  DT.95157379  DT.87017561 

    24/305 AceView cDNA sequences (see all 305):

    CA428135 BM825113 BE253201 AL136882 AI081970 BQ674397 BQ672179 BQ672982 
    BQ892694 CB122639 BI090035 BU189699 BQ014272 CD676085 BF063801 BM790273 
    AI679864 AW664542 BI222602 BE785995 AI341846 AU121681 AW069029 AK022241 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                    -     -     -                                                                                                                           
    SP2:                    -     -     -     -                                                                                                                     
    SP3:                    -     -                                                                                                                                 
    SP4:                          -                                                                                                                                 
    SP5:                                -                                                                                                                           

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
    SP1:                                                              -                           
    SP2:                                                                                          
    SP3:                                                                                          
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NAT10

    Expression
    for NAT10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGCCCGCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NAT10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    BoneRostral Skull Membranous BonesBone
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NAT10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAT10

    SOURCE GeneReport for Unigene cluster: Hs.577281
        SABiosciences Custom PCR Arrays for NAT10
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT10
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT10

    Orthologs
    for NAT10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NAT10 gene from 11/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nat101 , 5 N-acetyltransferase 101, 5 88.9(n)1
    95.61(a)1    		   2 (54.43 cM)5
    989561  NM_153126.21  NP_694766.11 
     1037212565 
    chicken
    (Gallus gallus)    		 Aves NAT101 N-acetyltransferase 10 (GCN5-related) 77.85(n)
    87.83(a)    		   426609  NM_001012940.1  NP_001012958.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NAT106
    		 --
    		 86(a)
    		 1 ↔ 1
    		 GL343283.1(1170479-1198400)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.137352 Xenopus laevis transcribed sequence with moderate similarity more 77.55(n)    CF285263.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc661192 hypothetical protein MGC66119 76.78(n)   393617  BC057462.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta l(1)G00201 lethal (1) G0020 57.09(n)
    54.6(a)    		   31811  NM_132275.1  NP_572503.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nath-101 Protein NATH-10 55.51(n)
    55.78(a)    		   172182  NM_059173.3  NP_491574.1 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes KRE33(YNL132W)4
    KRE331    		 Essential protein, required for biogenesis of the small more4
    Kre33p1    		 55.75(n)1
    58.36(a)1    		   14(375321-378491)4
    8555911, 4  NP_014267.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G104901 hypothetical protein 54.75(n)
    53.25(a)    		   837589  NM_100923.3  NP_172519.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.102952 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.26(n)    AK058272.1 


    ENSEMBL Gene Tree for NAT10 (if available)
    TreeFam Gene Tree for NAT10 (if available) 

    Paralogs
    for NAT10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for NAT10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    9 NCBI SNPs in NAT10 are shown     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452043731,2
    		--34125134(+) AAAGTA/TGCCAG 2 -- us2k10--------
    rs1476162251,2
    		--34125141(+) CCAGGC/TGTTGT 2 -- us2k10--------
    rs600158641,2
    		C,F,--34137686(+) CTCTCT/CGGTTC 1 -- int15Minor allele frequency- C:0.19WA CSA NA 245
    rs587550001,2
    		C,F,--34137713(+) TTAAAT/CGAGTG 1 -- int15Minor allele frequency- C:0.19WA CSA NA 245
    rs710373991,2
    		C--34151147(-) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs710374001,2
    		C,--34157436(-) AACCTC/-TGGGG 2 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs721946721,2
    		----34125283(+) AAAAA-/AAAAA 
                GGCTG     		2 -- us2k10--------
    rs113829451,2
    		----34141690(+) GTTGG-/TTTTTT 2 -- int1 trp30--------
    rs1424890051,2
    		----34125283(+) AAAAA-/AAGGCTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NAT10 (34127111 - 34169217 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NAT10: --
    Human Gene Mutation Database (HGMD): NAT10

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT10
    DNA2.0 Custom Variant and Variant Library Synthesis for NAT10

    Disorders / Diseases
    for NAT10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NAT10 for disorders           About GeneDecksing

    OMIM gene information: 609221    OMIM disorders: --

    5 diseases for NAT10:    About MalaCards
    hepatitis b    hepatitis    immunodeficiency    malaria
    carcinoma


    Export disorders for NAT10 gene to outside databases

    Publications
    for NAT10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAT10 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with NAT10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. (PubMed id 14592445)1, 2, 3, 9 Lv J.... Zhang B. (2003)
    2. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. (PubMed id 19303003)1, 2, 9 Shen Q....Zhang B. (2009)
    3. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. (PubMed id 17180247)1, 2, 9 Liu H....Zhang B. (2007)
    4. hALP, a novel transcriptional U three protein (t-UTP) , activates RNA polymerase I transcription by binding and acetylating the upstr eam binding factor (UBF). (PubMed id 21177859)1, 3 Kong R....Ke Y. (2011)
    5. Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. (PubMed id 18082603)1, 2 Fu D. and Collins K. (2007)
    6. Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. (PubMed id 17631499)1, 2 Chi Y.H....Jeang K.T. (2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)

    External Searches for NAT10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NAT10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55226 HGNC: 29830 AceView: FLJ10774 Ensembl:ENSG00000135372 euGenes: HUgn55226
    ECgene: NAT10 Kegg: 55226 H-InvDB: NAT10

    Other Databases showing NAT10 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1709

    Specialized Databases showing NAT10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAT10 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NAT10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NAT10 gene:
    Search GeneIP for patents involving NAT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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