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Aliases for NAT10 Gene

Aliases for NAT10 Gene

  • N-Acetyltransferase 10 (GCN5-Related) 2 3
  • N-Acetyltransferase 10 2 3
  • ALP 3 4
  • N-Acetyltransferase-Like Protein 3
  • EC 2.3.1.- 4
  • KIAA1709 4
  • NET43 3

External Ids for NAT10 Gene

Summaries for NAT10 Gene

GeneCards Summary for NAT10 Gene

NAT10 (N-Acetyltransferase 10 (GCN5-Related)) is a Protein Coding gene. Among its related pathways are Ribosome biogenesis in eukaryotes and Biological oxidations. GO annotations related to this gene include N-acetyltransferase activity.

UniProtKB/Swiss-Prot for NAT10 Gene

  • Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division.

Gene Wiki entry for NAT10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAT10 Gene

Genomics for NAT10 Gene

Genomic Location for NAT10 Gene

Start:
34,105,564 bp from pter
End:
34,151,034 bp from pter
Size:
45,471 bases
Orientation:
Plus strand

Genomic View for NAT10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAT10 Gene

Regulatory Elements for NAT10 Gene

Proteins for NAT10 Gene

  • Protein details for NAT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0A0-NAT10_HUMAN
    Recommended name:
    N-acetyltransferase 10
    Protein Accession:
    Q9H0A0
    Secondary Accessions:
    • B4DFD5
    • E7ESU4
    • E9PMN9
    • Q86WK5
    • Q9C0F4
    • Q9HA61
    • Q9NVF2

    Protein attributes for NAT10 Gene

    Size:
    1025 amino acids
    Molecular mass:
    115730 Da
    Quaternary structure:
    • Interacts with SUN1 (via N-terminus). Also interacts with TERT.
    SequenceCaution:
    • Sequence=AAO49126.1; Type=Frameshift; Positions=981; Evidence={ECO:0000305}; Sequence=BAB21800.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NAT10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAT10 Gene

Proteomics data for NAT10 Gene at MOPED

Post-translational modifications for NAT10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys904 and Lys956

Other Protein References for NAT10 Gene

No data available for DME Specific Peptides for NAT10 Gene

Domains for NAT10 Gene

UniProtKB/Swiss-Prot:

NAT10_HUMAN
Domain:
  • Contains 1 N-acetyltransferase domain.:
    • Q9H0A0
Family:
  • Belongs to the UPF0202 family.:
    • Q9H0A0
genes like me logo Genes that share domains with NAT10: view

No data available for Gene Families for NAT10 Gene

Function for NAT10 Gene

Molecular function for NAT10 Gene

UniProtKB/Swiss-Prot Function: Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division.
UniProtKB/Swiss-Prot Induction: Transcriptionally activated by genotoxic agents; possible role in DNA damage and induction of cellular resistance to genotoxic agents.

Enzyme Numbers (IUBMB) for NAT10 Gene

Gene Ontology (GO) - Molecular Function for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008080 N-acetyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NAT10: view

Phenotypes for NAT10 Gene

MGI mutant phenotypes for NAT10:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NAT10: view

miRNA for NAT10 Gene

miRTarBase miRNAs that target NAT10

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NAT10 Gene

Localization for NAT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAT10 Gene

Nucleus, nucleolus. Note=Nucleolar in interphase and redistributes to the perichromosomal layer and to the midbody during telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAT10 Gene COMPARTMENTS Subcellular localization image for NAT10 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11214970
GO:0005730 nucleolus IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NAT10: view

Pathways for NAT10 Gene

genes like me logo Genes that share pathways with NAT10: view

Pathways by source for NAT10 Gene

1 BioSystems pathway for NAT10 Gene
1 KEGG pathway for NAT10 Gene

Gene Ontology (GO) - Biological Process for NAT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with NAT10: view

Transcripts for NAT10 Gene

Unigene Clusters for NAT10 Gene

N-acetyltransferase 10 (GCN5-related):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAT10 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: -
SP6:

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NAT10 Gene

GeneLoc Exon Structure for
NAT10
ECgene alternative splicing isoforms for
NAT10

Expression for NAT10 Gene

mRNA expression in normal human tissues for NAT10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAT10 Gene

SOURCE GeneReport for Unigene cluster for NAT10 Gene Hs.577281

genes like me logo Genes that share expressions with NAT10: view

Orthologs for NAT10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAT10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAT10 36
  • 99.46 (n)
  • 99.68 (a)
NAT10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAT10 36
  • 91 (n)
  • 96.55 (a)
NAT10 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAT10 36
  • 90.74 (n)
  • 96.14 (a)
NAT10 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nat10 36
  • 88.88 (n)
  • 95.66 (a)
Nat10 16
Nat10 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAT10 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 88 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nat10 36
  • 86.16 (n)
  • 93.16 (a)
chicken
(Gallus gallus)
Aves NAT10 36
  • 77.84 (n)
  • 88.1 (a)
NAT10 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAT10 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13735 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nat10 36
  • 74.36 (n)
  • 83.63 (a)
zebrafish
(Danio rerio)
Actinopterygii nat10 36
  • 73.19 (n)
  • 81.4 (a)
nat10 37
  • 80 (a)
OneToOne
zgc66119 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010491 36
  • 57.33 (n)
  • 56.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)G0020 36
  • 57.28 (n)
  • 54.8 (a)
l(1)G0020 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nath-10 36
  • 55.92 (n)
  • 56.99 (a)
nath-10 37
  • 53 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR346C 36
  • 56.98 (n)
  • 58.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KRE33 36
  • 55.61 (n)
  • 58.27 (a)
KRE33 37
  • 55 (a)
OneToOne
KRE33 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F24398g 36
  • 55.72 (n)
  • 58.51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G10490 36
  • 54.95 (n)
  • 53.79 (a)
rice
(Oryza sativa)
Liliopsida Os.10295 36
Os12g0170700 36
  • 49.86 (n)
  • 44.42 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10654 36
  • 57.16 (n)
  • 59.07 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC20G8.09c 36
  • 55.62 (n)
  • 56.93 (a)
Species with no ortholog for NAT10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAT10 Gene

ENSEMBL:
Gene Tree for NAT10 (if available)
TreeFam:
Gene Tree for NAT10 (if available)

Paralogs for NAT10 Gene

No data available for Paralogs for NAT10 Gene

Variants for NAT10 Gene

Sequence variations from dbSNP and Humsavar for NAT10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8187 -- 34,146,606(-) AGACC(C/T)AGCGG utr-variant-3-prime
rs1883958 -- 34,105,575(-) GAGAA(C/G)GGACC utr-variant-5-prime, upstream-variant-2KB
rs1983642 -- 34,146,278(-) CTCTC(C/G)TTGCT utr-variant-3-prime
rs2024624 -- 34,106,661(-) CTCTT(C/G)CCAGT intron-variant
rs2295078 -- 34,142,501(-) AGGCA(A/G)TTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAT10 Gene

Variant ID Type Subtype PubMed ID
nsv509400 CNV Insertion 20534489

Relevant External Links for NAT10 Gene

HapMap Linkage Disequilibrium report
NAT10
Human Gene Mutation Database (HGMD)
NAT10

Disorders for NAT10 Gene

No disorders were found for NAT10 Gene.

No data available for UniProtKB/Swiss-Prot for NAT10 Gene

Publications for NAT10 Gene

  1. Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT. (PMID: 14592445) Lv J. … Zhang B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23
  2. DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation. (PMID: 17180247) Liu H. … Zhang B. (Mol. Cell. Biochem. 2007) 3 4 23
  3. NAT10, a nucleolar protein, localizes to the midbody and regulates cytokinesis and acetylation of microtubules. (PMID: 19303003) Shen Q. … Zhang B. (Exp. Cell Res. 2009) 3 4 23
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for NAT10 Gene

Sources for NAT10 Gene

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