Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NAT1 Gene

protein-coding GIFtS: 70
GCID: GC08P018031

N-acetyltransferase 1 (arylamine N-acetyltransferase)

(Previous symbol: AAC1)

Explore 79 diseases affiliated with
NAT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
N-Acetyltransferase 1 (Arylamine N-Acetyltransferase)¹ ²		NAT-1² ³
AAC1¹ ² ³ ⁵		N-Acetyltransferase Type 1² ³
Arylamide Acetylase 1² ³		EC 2.3.1.5³ ⁸
Monomorphic Arylamine N-Acetyltransferase² ³		NATI²
MNAT² ³		Arylamine N-Acetyltransferase 1²

External Ids:	HGNC: 7645¹	Entrez Gene: 9²	Ensembl: ENSG00000171428⁷	OMIM: 108345⁵	UniProtKB: P18440³

Export aliases for NAT1 gene to outside databases

Previous GC identifers: GC08P017943 GC08P018130 GC08P018077 GC08P018111 GC08P016611 GC08P018029

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAT1:

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse

and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to

various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in

folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. (provided

by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or

O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known

carcinogens

Gene Wiki entry for NAT1 (N-acetyltransferase 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_167187.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NAT1 gene promoter:
GR PPAR-gamma1 Sp1 GR-beta Msx-1 GR-alpha PPAR-gamma2 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAT1 promoter sequence

Search SABiosciences Chromatin IP Primers for NAT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22

NAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P018031: view genomic region (about GC identifiers)

Start:	18,027,986 bp from pter	End:	18,081,198 bp from pter
Size:	53,213 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440 (See protein sequence)

Recommended Name: Arylamine N-acetyltransferase 1

Size: 290 amino acids; 33899 Da

Subcellular location: Cytoplasm

Miscellaneous: NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at the

NAT1 locus suggest that it is a polymorphically expressed enzyme

Caution: The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported by

the nomenclature committee

4 PDB 3D structures from and Proteopedia for NAT1:

2DSS (3D)

2GWU (3D)

2IJA (3D)

2PQT (3D)

Secondary accessions: A8K4E7 O15159 O15300 Q546N1 Q96TE9

Explore the universe of human proteins at neXtProt for NAT1: NX_P18440

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18440

4/9 DME Specific Peptides for NAT1 (P18440) (see all 9)

GVHCLVG

SFCSLQT

ILQHQIRA

YIVDAGFG

NAT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (9 alternative transcripts):

NP_000653.3 NP_001153642.1 NP_001153643.1 NP_001153644.1 NP_001153645.1 NP_001153646.1 NP_001153647.1 NP_001153648.1

NP_001153651.1

ENSEMBL proteins:

ENSP00000307218 ENSP00000428270 ENSP00000429407 ENSP00000429341 ENSP00000443194

ENSP00000444609 ENSP00000440434 ENSP00000440900

Reactome Protein details: P18440
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 8): NAT1 OriGene Custom Protein Services for NAT1
	GenScript Custom Purified and Recombinant Proteins Services for NAT1
	Novus Biologicals NAT1 Proteins Novus Biologicals NAT1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NAT1
	Uscn Proteins for NAT1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

NAT1 for ontologies About GeneDecksing

NAT1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies (see all 2): NAT1 OriGene Custom Antibody Services for NAT1
	GenScript Custom Superior Antibodies Services for NAT1
	Novus Biologicals NAT1 Antibodies
	Abcam antibodies for NAT1
	Uscn Antibodies for NAT1
	ThermoFisher Antibody for NAT1

Assay Products for NAT1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NAT1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NAT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NAT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR001447 Arylamine_N-AcTrfase

Graphical View of Domain Structure for InterPro Entry P18440

ProtoNet protein and cluster: P18440

1 Blocks protein family: IPB004081 Arylamine N-acetyltransferase signature

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Similarity: Belongs to the arylamine N-acetyltransferase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or

O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known

carcinogens

Catalytic activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

Genatlas biochemistry entry for NAT1:

arylamine N-acetyltransferase 1,widely expressed,monomorphic,also involved in bladder carcinogenesis

Enzyme Number (IUBMB): EC 2.3.1.5¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 9): NAT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NAT1
		SwitchGear 3'UTR luciferase reporter plasmid: NAT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT1 (see all 7) OriGene shRNA RFP: NAT1 OriGene siRNA: NAT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NAT1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT1 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT1 (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): NAT1 (NM_000662)
		Sino Biological Human cDNA Clone for NAT1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NAT1
		Search LifeMap BioReagents cell lines for NAT1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004060	arylamine N-acetyltransferase activity	IEA	--
GO:0016407	acetyltransferase activity	--	--

NAT1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for NAT1:

Decreased homologous recombina

Increased S DNA content

Animal Models:
Mouse knock-out Nat1/Nat2^Nat1/tm1Kss for NAT1
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nat2):

embryogenesis	homeostasis/metabolism	nervous system	normal	reproductive system
vision/eye

NAT1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Biological oxidations

	Biological oxidations	1.00			metapathway biotransformation	0.41
	Phase II conjugation	0.52

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Acetylation

Acetylation

1.00

Busulfan Pathway, Pharmacodynamics

Busulfan Pathway, Pharmacodynamics

1.00

Arylamine metabolism

Arylamine metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for NAT1

	Arylamine metabolism
	metapathway biotransformation

4 Reactome Pathways for NAT1

	Metabolism
	Biological oxidations
	Acetylation
	Phase II conjugation

1 PharmGKB Pathway for NAT1

Busulfan Pathway, Pharmacodynamics

3 Kegg Pathways (Kegg details for NAT1):

	Caffeine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways

NAT1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NAT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/10 Interacting proteins for NAT1 (P18440³ ENSP00000307218⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NAA10	P41227³, ENSP00000417763⁴	I2D: score=2 STRING: ENSP00000417763
SNTA1	Q13424³	I2D: score=1
CYP1A2	ENSP00000342007⁴	STRING: ENSP00000342007
CYP2A6	ENSP00000301141⁴	STRING: ENSP00000301141
XDH	ENSP00000368727⁴	STRING: ENSP00000368727

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006805	xenobiotic metabolic process	TAS	--
GO:0044281	small molecule metabolic process	TAS	--

NAT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NAT1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NAT1

6 HMDB Compounds for NAT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
3-Aminosalicylic acid	3-Amino Salicylate (see all 16)	570-23-0	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Aniline	Aminobenzene (see all 16)	62-53-3	--
Coenzyme A	Acetoacetyl coenzyme A sodium salt (see all 21)	85-61-0	--
N-Acetylarylamine	N-Acetylarylamine	55576-55-1	--
Paraxanthine	1,7-Dimethylxanthine (see all 2)	611-59-6	--

1 DrugBank Compound for NAT1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Sulfamethoxazole	--	723-46-6	enzyme	substrate	19515014

10/51 Novoseek chemical compound relationships for NAT1 gene (see all 51) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
arylamine	97.6	180	8861781 (6), 11436130 (3), 9511183 (2), 16829624 (2) (see all 89)
2-aminofluorene	89.7	10	16314733 (1), 16829624 (1), 8179482 (1), 9571233 (1) (see all 9)
paba	88.8	47	11108798 (4), 10692486 (3), 7756106 (1), 7585581 (1) (see all 20)
para aminosalicylic acid	80.6	20	9511182 (2), 7929420 (2), 9342682 (2), 10692486 (1) (see all 9)
n-hydroxy-2-aminofluorene	80.5	4	8425184 (3), 8353847 (1)
p-acetamidobenzoylglutamate	79.6	3	9839355 (1), 11113560 (1)
sulfadiazine	77.9	20	1762071 (2), 7929420 (2), 7585581 (1), 10604942 (1) (see all 12)
2-naphthylamine	76.6	1	8353847 (1)
hydrazine	76.2	10	18288399 (1), 11108798 (1), 12832400 (1), 12878219 (1) (see all 6)
phip	76.2	5	8179482 (1), 10381774 (1), 12618593 (1), 14601045 (1)

5 PharmGKB related drug/compound annotations for NAT1 gene

Drug/compound	PharmGKB Annotation
hydralazine	DL
isoniazid	DL
isosorbide dinitrate	DL
pyrazinamide	DL
rifampin	DL

About this table

Search CenterWatch for drugs/clinical trials and news about NAT1 / ARY1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NAT1 gene (9 alternative transcripts):

NM_000662.5 NM_001160170.1 NM_001160171.1 NM_001160172.1 NM_001160173.1 NM_001160174.1 NM_001160175.1 NM_001160176.1

NM_001160179.1

Unigene Cluster for NAT1:

N-acetyltransferase 1 (arylamine N-acetyltransferase)

Hs.591847 [show with all ESTs]

Unigene Representative Sequence: NM_001160170

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000517441 ENST00000307719(uc003wyq.3) ENST00000518029 ENST00000517574

ENST00000519006 ENST00000517837 ENST00000517492 ENST00000520546(uc011kyl.2)

ENST00000545197(uc003wyt.3 uc003wys.3) ENST00000535084(uc010ltd.3)

ENST00000539092(uc003wyu.3 uc003wyv.3 uc003wyr.3) ENST00000541942(uc010ltc.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 9): NAT1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAT1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NAT1
		SwitchGear 3'UTR luciferase reporter plasmid: NAT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT1 (see all 7) OriGene shRNA RFP: NAT1 OriGene siRNA: NAT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT1 (see all 12) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT1 (see all 9) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 9): NAT1 (NM_000662)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NAT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT1

Additional cDNA sequence:

AJ581135.1 AJ581136.1 AJ581137.1 AJ581138.1 AJ581139.1 AJ581140.1 AJ581141.1 AJ581142.1

AJ581143.1 AJ581151.2 AJ581153.1 AJ581154.1 AJ581155.1 AK290912.1 BC013732.1 BC047666.1

BX647521.1 D90041.1 S78829.1

10 DOTS entries:

DT.95269815 DT.212955 DT.121491296 DT.75190644 DT.121491283 DT.100746983 DT.40261666 DT.92018326

DT.97824906 DT.121491295

24/65 AceView cDNA sequences (see all 65):

D78248 BM926650 CR596299 BQ231158 NM_000662 BG941635 BQ024509 BF594441

BM924372 CD511345 BX647521 BC047666 D90041 CB852436 AI022585 BC013732

BG656530 BX112361 AI888631 BU753390 BG654454 T29485 BU689480 BF034718

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NAT1 (see all 9) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:			-		-		-		-		-		-
SP2:							-		-		-		-
SP3:							-		-						-
SP4:											-		-		-
SP5:													-		-

ECgene alternative splicing isoforms for NAT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NAT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTTCTGT

About this image

NAT1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Induced pluripotent stem cell line 201B6 (Induced Pluripotent Stem Cell)

Early Embryo, Fibroblast

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NAT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAT1

SOURCE GeneReport for Unigene cluster: Hs.591847

SABiosciences Expression via Pathway-Focused PCR Arrays including NAT1:

Cancer Drug Resistance in human mouse rat

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NAT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for NAT1 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	PNAT10¹	arylamine N-acetyltransferase, pineal gland isozyme more	64.02(n) 57.93(a)		396283 NM_205340.1 NP_990671.1
lizard (Anolis carolinensis)	Reptilia	--	--	53(a)	1 → many	GL343663.1(8584-9450)
zebrafish (Danio rerio)	Actinopterygii	LOC794381¹	arylamine N-acetyltransferase, pineal gland isozyme more	52.31(n) 43.4(a)		794381 XM_001334286.1 XP_001334322.1
E. coli (Escherichia coli)	Gamma proteobacteria	nhoA⁶	N-hydroxyarylamine O-acetyltransferase	22(a)	1 → many	Chromosome(1532048-1532893)

ENSEMBL Gene Tree for NAT1 (if available)
TreeFam Gene Tree for NAT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NAT1 gene

NAT2²

1 SIMAP similar gene for NAT1 using alignment to 7 protein entries: ARY1_HUMAN (see all proteins):

NAT2

NAT1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NAT1
PGOHUM00000260428

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Polymorphism: N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been implicated

in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated with significant

lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10 allele has been

associated with increased risk of colon and urinary bladder cancers and with higher levels of N-acetyltransferase

activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4987076^1,2	C,F,H,	pathogenic	23709274(+)	`CTTGTG/ATCTTC`	18	/I /V	mis¹ ese³		19	MN NA NS EA EU	7495
rs28739037^1,2	C,F,	--	16570445(+)	`GAGATG/AGGCAG`	1	--	us2k¹		2	NS WA	298
rs28739039^1,2	C,	--	16570480(+)	`ACCAGC/ACTAGG`	1	--	us2k¹		1	NS	180
rs2410466^1,2	C,F,	--	16570749(+)	`ctcttC/Taatca`	1	--	us2k¹		4	NA NS WA	302
rs28739044^1,2	C,F,	--	16570834(+)	`TAAACT/GCACAA`	1	--	us2k¹		4	NS NA EA	422
rs28739045^1,2	C,F,	--	16570840(+)	`CACAAT/CAGATT`	1	--	us2k¹		4	NS WA CSA	302
rs73587950^1,2	C,	--	16570851(+)	`CAACAC/TTGAAA`	1	--	us2k¹		2	WA	120
rs1121746^1,2	C,F,	--	16570896(+)	`acataG/Atgggg`	1	--	us2k¹		3	NA NS WA	300
rs28739046^1,2	C,F,	--	16571293(+)	`CTCACA/CCCTGT`	1	--	us2k¹		4	NS WA	298
rs12019382^1,2	F,	--	16571624(+)	`aatgtG/Tgtatg`	1	--	us2k¹		1	WA	118

HapMap Linkage Disequilibrium report for NAT1 (18027986 - 18081198 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NAT1
1 CNV: 4585
Human Gene Mutation Database (HGMD): NAT1

Locus Specific Mutation Databases (LSDB): NAT1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT1

DNA2.0 Custom Variant and Variant Library Synthesis for NAT1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NAT1 for disorders           About GeneDecksing

OMIM gene information: 108345    OMIM disorders: --

20/79 diseases for NAT1 (see all 79):    About MalaCards

neural tube defect drug-induced hepatitis talipes equinovarus spina bifida

multiple chemical sensitivity malignant pleural mesothelioma non-hodgkin lymphoma cleft palate

familial adenomatous polyposis substance abuse orofacial cleft urinary bladder cancer

peptic ulcer lymphoblastic leukemia systemic lupus erythematosus cystic fibrosis

lupus erythematosus hodgkin's lymphoma inflammatory bowel disease motor neuron disease

1 disease from the University of Copenhagen DISEASES database for NAT1:

Urinary bladder cancer

10/36 Novoseek disease relationships for NAT1 gene (see all 36) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bladder cancer	70.9	38	11431340 (4), 9107426 (4), 14564055 (4), 17026750 (2) (see all 17)
colorectal cancer	54	38	16434594 (5), 7627961 (4), 9528834 (3), 15736440 (3) (see all 14)
genetic susceptibility	51	5	18259988 (1), 10667461 (1), 12485520 (1)
cancer	50.9	84	10667461 (5), 12351146 (3), 18259988 (2), 14672957 (2) (see all 48)
breast cancer	27.7	51	20100460 (4), 12860276 (4), 10090301 (3), 17973251 (3) (see all 20)
pancreatic cancer	25.6	14	15987714 (4), 18006927 (2), 9696930 (1), 11095579 (1) (see all 5)
neural tube defects	25.6	2	10767335 (1)
colon cancer	25.1	13	18022202 (4), 18569593 (2), 12568823 (1), 10493262 (1)
lymphoblastic leukemia acute childhood	24.9	1	10868688 (1)
cancer lung	22.9	17	9731715 (4), 9626964 (3), 16835348 (1), 18258609 (1) (see all 6)

Genetic Association Database (GAD): NAT1
Human Genome Epidemiology (HuGE) Navigator: NAT1 (248 documents)

Export disorders for NAT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NAT1 gene, integrated from 9 sources (see all 411):
(articles sorted by number of sources associating them with NAT1)

Utopia: connect your pdf to the dynamic
world of online information

Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China? (PubMed id 15770721)^{1, 4, 9} Zhang X.F....Tang B.M. (2005)
Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations. (PubMed id 9511183)^{1, 2, 9} Butcher N.J.... Minchin R.F. (1998)
NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant. (PubMed id 15142281)^{1, 4, 9} Johnson N....Sim E. (2004)
Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in Caucasians. (PubMed id 15725609)^{1, 4, 9} Gu J....Wu X. (2005)
N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer. (PubMed id 12860276)^{1, 4, 9} Lee K.M....Kang D. (2003)
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. (PubMed id 12355549)^{1, 4, 9} Hein D.W....Caporaso N.E. (2002)
[The research the relationship between N-acetyltransferase 1 gene polymorphisms and genetic susceptibility to sporadic colorectal adenocarcinoma] (PubMed id 12485520)^{1, 4, 9} Zhang Y....Zhou Y. (2002)
Association of arylamine N-acetyltransferase (NAT1 and NAT2) genotypes with urinary bladder cancer risk. (PubMed id 14564055)^{1, 4, 9} Jaskul/a-Sztul R....Szyfter K. (2001)
Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: significantly reduced risk in subjects with NAT1*10. (PubMed id 11431340)^{1, 4, 9} Cascorbi I....Brockmoller J. (2001)
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus. (PubMed id 8442668)^{1, 2, 9} Vatsis K.P. and Weber W.W. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9	HGNC: 7645	AceView: NAT1	Ensembl:ENSG00000171428	euGenes: HUgn9
ECgene: NAT1	Kegg: 9	H-InvDB: NAT1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NAT1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NAT1	Genetics and Cytogenetics in Oncology and Haematology
NAT	http://www.louisville.edu/medschool/pharmacology/NAT.html
NIEHS-SNPs	http://egp.gs.washington.edu/data/nat1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT1

Intellectual Property for NAT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NAT1 gene:
Search GeneIP for patents involving NAT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for NAT1		OriGene shRNA RFP for NAT1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAT1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAT1
	OriGene Protein Over-expression Lysate for NAT1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NAT1		OriGene 3'-UTR Clone for NAT1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAT1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAT1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NAT1		OriGene Custom Protein Services for NAT1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAT1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAT1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAT1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAT1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAT1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAT1

	GenScript Custom Purified and Recombinant Proteins Services for NAT1		GenScript cDNA clones with any tag delivered in your preferred vector for NAT1
	GenScript Custom Assay Services for NAT1		GenScript Custom Superior Antibodies Services for NAT1
	GenScript Custom overexpressing Cell Line Services for NAT1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NAT1 promoter
	Search Chromatin IP Primers for NAT1
	RT² qPCR Primer Assay in human, mouse, rat NAT1
	GNC Network for NAT1
	SABiosciences PCR Arrays including human, mouse, rat NAT1

Search Tocris compounds for NAT1

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for NAT1
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NAT1 antibodies
	NAT1 proteins
	NAT1 lysates

	Antibodies for NAT1
	See all of Abcam's Antibodies, Kits and Proteins for NAT1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for NAT1

NAT1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NAT1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT1

	SwitchGear 3'UTR luciferase reporter plasmids for NAT1
	SwitchGear Promoter luciferase reporter plasmids for NAT1

ThermoFisher Antibody for NAT1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NAT1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

NAT1 Gene

N-acetyltransferase 1 (arylamine N-acetyltransferase)

Aliases
for NAT1 gene

Summaries
for NAT1 gene

Genomic Views
for NAT1 gene

Proteins
for NAT1 gene

Protein Domains /
Families
for NAT1 gene

Function
for NAT1 gene

Pathways & Interactions
for NAT1 gene

Drugs & Compounds
for NAT1 gene

Transcripts
for NAT1 gene

Expression
for NAT1 gene

Orthologs
for NAT1 gene

Paralogs
for NAT1 gene

Genomic Variants
for NAT1 gene

Disorders / Diseases
for NAT1 gene

Publications
for NAT1 gene

External Searches for NAT1 gene

Genome Databases showing NAT1 gene

Other Databases showing NAT1 gene

Specialized Databases showing NAT1 gene

Intellectual Property
for NAT1 gene

Products
for NAT1 gene

View Random Gene

Gastric Cancer
Lymphoblastic Leukemia Acute Childhood
BREAST CARCINOMA
bladder cancer
Colon Cancer
Genetic Susceptibility
Cystic Fibrosis
Polyps
Carcinoma
allergy
Leukemia
Osteosarcoma
Breast Cancer
Cataract
Laryngeal Cancer
Adenocarcinoma
Neural Tube Defects
Carcinoma Transitional Cell
Cancer
Cleft Palate
Pancreatic Cancer
Cancer Lung
ADENOCARCINOMA GASTRIC
Colorectal Cancer
Adenoma
Cholangiocarcinoma
Bladder Tumors
Colorectal Tumors
Spina Bifida
prostate cancer
Chromosomal Aberrations
Tumors
Lymphoma Non-Hodgkins
leukemogenesis
SMOKING HABIT
Cleft Lip

Advanced Search

Export list of displayed genes

NAT1 Gene

N-acetyltransferase 1 (arylamine N-acetyltransferase)

Aliasesfor NAT1 gene

Summariesfor NAT1 gene

Genomic Viewsfor NAT1 gene

Proteinsfor NAT1 gene

Protein Domains /Familiesfor NAT1 gene

Functionfor NAT1 gene

Pathways & Interactionsfor NAT1 gene

Drugs & Compoundsfor NAT1 gene

Transcriptsfor NAT1 gene

Expression for NAT1 gene

Orthologsfor NAT1 gene

Paralogsfor NAT1 gene

Genomic Variantsfor NAT1 gene

Disorders / Diseasesfor NAT1 gene

Publicationsfor NAT1 gene

External Searches for NAT1 gene

Genome Databases showing NAT1 gene

Other Databases showing NAT1 gene

Specialized Databases showing NAT1 gene

Intellectual Propertyfor NAT1 gene

Productsfor NAT1 gene

View Random Gene

Aliases
for NAT1 gene

Summaries
for NAT1 gene

Genomic Views
for NAT1 gene

Proteins
for NAT1 gene

Protein Domains /
Families
for NAT1 gene

Function
for NAT1 gene

Pathways & Interactions
for NAT1 gene

Drugs & Compounds
for NAT1 gene

Transcripts
for NAT1 gene

Expression
for NAT1 gene

Orthologs
for NAT1 gene

Paralogs
for NAT1 gene

Genomic Variants
for NAT1 gene

Disorders / Diseases
for NAT1 gene

Publications
for NAT1 gene

Intellectual Property
for NAT1 gene

Products
for NAT1 gene