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NAT1 Gene

protein-coding   GIFtS: 71
GCID: GC08P018041

N-Acetyltransferase 1 (Arylamine N-Acetyltransferase)


(Previous symbol: AAC1)
  See NAT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acetyltransferase 1 (Arylamine N-Acetyltransferase)1 2     NAT-12 3
AAC11 2 3 5     N-Acetyltransferase Type 12 3
Arylamide Acetylase 12 3     EC 2.3.1.53 8
Monomorphic Arylamine N-Acetyltransferase2 3     NATI2
MNAT2 3     Arylamine N-Acetyltransferase 12

External Ids:    HGNC: 76451   Entrez Gene: 92   Ensembl: ENSG000001714287   OMIM: 1083455   UniProtKB: P184403   

Export aliases for NAT1 gene to outside databases

Previous GC identifers: GC08P017943 GC08P018130 GC08P018077 GC08P018111 GC08P016611 GC08P018029 GC08P018031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAT1 Gene:
This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the
mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from
acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other
xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for NAT1 Gene:
NAT1 (N-acetyltransferase 1 (arylamine N-acetyltransferase)) is a protein-coding gene. Diseases associated with NAT1 include orthostatic intolerance, and multiple chemical sensitivity. GO annotations related to this gene include arylamine N-acetyltransferase activity. An important paralog of this gene is NAT2.

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440
Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or
O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known
carcinogens

Gene Wiki entry for NAT1 (N-acetyltransferase 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAT1 gene promoter:
         GR   PPAR-gamma1   Sp1   GR-beta   Msx-1   GR-alpha   PPAR-gamma2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAT1 promoter sequence
   Search Chromatin IP Primers for NAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

NAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAT1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P018041:  view genomic region     (about GC identifiers)

Start:
18,027,986 bp from pter      End:
18,081,198 bp from pter
Size:
53,213 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440 (See protein sequence)
Recommended Name: Arylamine N-acetyltransferase 1  
Size: 290 amino acids; 33899 Da
Miscellaneous: NAT1 was historically considered to be monomorphic in nature but reports of allelic variations at
the NAT1 locus suggest that it is a polymorphically expressed enzyme
Caution: The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic variation as reported
by the nomenclature committee
4 PDB 3D structures from and Proteopedia for NAT1:
2DSS (3D)        2GWU (3D)        2IJA (3D)        2PQT (3D)    
Secondary accessions: A8K4E7 O15159 O15300 Q546N1 Q96TE9

Explore the universe of human proteins at neXtProt for NAT1: NX_P18440

Explore proteomics data for NAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys18
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NAT1 (P18440) (see all 9)
     GVHCLVG  SFCSLQT  ILQHQIRA  YIVDAGFG 


    See NAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_000653.3  NP_001153642.1  NP_001153643.1  NP_001153644.1  NP_001153645.1  NP_001153646.1  NP_001153647.1  NP_001153648.1  
    NP_001153651.1  

    ENSEMBL proteins: 
     ENSP00000307218   ENSP00000428270   ENSP00000429407   ENSP00000429341   ENSP00000443194  
     ENSP00000444609   ENSP00000440434   ENSP00000440900  
    Reactome Protein details: P18440

    NAT1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for NAT1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NAT1
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    Novus Biologicals NAT1 Proteins
    Novus Biologicals NAT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NAT1
    Cloud-Clone Corp. Proteins for NAT1

     
    Search eBioscience for Proteins for NAT1 

    NAT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for NAT1

    NAT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NAT1
    Cloud-Clone Corp. CLIAs for NAT1
    Search eBioscience for ELISAs for NAT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001447 Arylamine_N-AcTrfase

    Graphical View of Domain Structure for InterPro Entry P18440

    ProtoNet protein and cluster: P18440

    1 Blocks protein domain: IPB004081 Arylamine N-acetyltransferase signature

    UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440
    Similarity: Belongs to the arylamine N-acetyltransferase family


    Find genes that share domains with NAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARY1_HUMAN, P18440
    Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or
    O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known
    carcinogens
    Catalytic activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

         Genatlas biochemistry entry for NAT1:
    arylamine N-acetyltransferase 1,widely expressed,monomorphic,also involved in bladder carcinogenesis

         Enzyme Number (IUBMB): EC 2.3.1.51 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004060arylamine N-acetyltransferase activity IEA--
    GO:0016407acetyltransferase activity ----
         
    Find genes that share ontologies with NAT1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAT1:
     Decreased homologous recombina  Increased S DNA content 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nat2):
     embryogenesis  homeostasis/metabolism  nervous system  normal  reproductive system 
     vision/eye 

    Find genes that share phenotypes with NAT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nat1/Nat2Nat1/tm1Kss for NAT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAT1

    miRNA
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    miRTarBase miRNAs that target NAT1:
    hsa-mir-25-3p (MIRT050208), hsa-mir-26b-5p (MIRT030309)

    Block miRNA regulation of human, mouse, rat NAT1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NAT1
    SwitchGear 3'UTR luciferase reporter plasmidNAT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAT1
    Predesigned siRNA for gene silencing in human, mouse, rat NAT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAT1

    Clone
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    OriGene clones in human, mouse for NAT1 (see all 53)
    OriGene ORF clones in mouse, rat for NAT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): NAT1 (NM_000662)
    Sino Biological Human cDNA Clone for NAT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT1
    Addgene plasmids for NAT1 

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    GenScript Custom overexpressing Cell Line Services for NAT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARY1_HUMAN, P18440: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with NAT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAT1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Biological oxidations
    Biological oxidations0.56
    metapathway biotransformation0.42
    Phase II conjugation0.56
    2Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Arylamine metabolism0.00
    3Caffeine Pathway, Pharmacokinetics
    Caffeine metabolism0.44
    Acetylation0.00
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Glucuronidation
    Drug metabolism - other enzymes0.36


    Find genes that share SuperPaths with NAT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NAT1
        Arylamine metabolism
    metapathway biotransformation


    1 Reactome Pathway for NAT1
        Acetylation

    1 PharmGKB Pathway for NAT1
        Busulfan Pathway, Pharmacodynamics

    4 Kegg Pathways  (Kegg details for NAT1):
        Caffeine metabolism
    Drug metabolism - other enzymes
    Metabolic pathways
    Chemical carcinogenesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NAT1: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for NAT1 (P184403 ENSP000003072184) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAA10P412273, ENSP000004177634I2D: score=2 STRING: ENSP00000417763
    SNTA1Q134243I2D: score=1 
    CYP1A2ENSP000003420074STRING: ENSP00000342007
    CYP2A6ENSP000003011414STRING: ENSP00000301141
    XDHENSP000003687274STRING: ENSP00000368727
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006805xenobiotic metabolic process TAS--
    GO:0008152metabolic process ----
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAT1 (ARY1)

    6 HMDB Compounds for NAT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-Aminosalicylic acid3-Amino Salicylate (see all 16)570-23-0--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    AnilineAminobenzene (see all 16)62-53-3--
    Coenzyme AAcetoacetyl coenzyme A sodium salt (see all 21)85-61-0--
    N-AcetylarylamineN-Acetylarylamine 55576-55-1--
    Paraxanthine1,7-Dimethylxanthine (see all 2)611-59-6--

    1 DrugBank Compound for NAT1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sulfamethoxazole-- 723-46-6enzymesubstrate19515014

    Selected Novoseek inferred chemical compound relationships for NAT1 gene (see all 51)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    arylamine 97.6 180 8861781 (6), 11436130 (3), 9511183 (2), 16829624 (2) (see all 89)
    2-aminofluorene 89.7 10 16314733 (1), 16829624 (1), 8179482 (1), 9571233 (1) (see all 9)
    paba 88.8 47 11108798 (4), 10692486 (3), 7756106 (1), 7585581 (1) (see all 20)
    para aminosalicylic acid 80.6 20 9511182 (2), 7929420 (2), 9342682 (2), 10692486 (1) (see all 9)
    n-hydroxy-2-aminofluorene 80.5 4 8425184 (3), 8353847 (1)
    p-acetamidobenzoylglutamate 79.6 3 9839355 (1), 11113560 (1)
    sulfadiazine 77.9 20 1762071 (2), 7929420 (2), 7585581 (1), 10604942 (1) (see all 12)
    2-naphthylamine 76.6 1 8353847 (1)
    hydrazine 76.2 10 18288399 (1), 11108798 (1), 12832400 (1), 12878219 (1) (see all 6)
    phip 76.2 5 8179482 (1), 10381774 (1), 12618593 (1), 14601045 (1)



    Find genes that share compounds with NAT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAT1 gene (9 alternative transcripts): 
    NM_000662.6  NM_001160170.2  NM_001160171.2  NM_001160172.2  NM_001160173.2  NM_001160174.2  NM_001160175.2  NM_001160176.2  
    NM_001160179.2  

    Unigene Cluster for NAT1:

    N-acetyltransferase 1 (arylamine N-acetyltransferase)
    Hs.591847  [show with all ESTs]
    Unigene Representative Sequence: NM_001160170
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517441 ENST00000307719(uc003wyq.3) ENST00000518029 ENST00000517574
    ENST00000519006 ENST00000517837 ENST00000517492 ENST00000520546(uc011kyl.2)
    ENST00000545197(uc003wyt.3 uc003wys.3) ENST00000535084(uc010ltd.3)
    ENST00000539092(uc003wyu.3 uc003wyv.3 uc003wyr.3) ENST00000541942(uc010ltc.3)

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 9): NAT1 (NM_000662)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAT1
    Addgene plasmids for NAT1 
    Primer
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    OriGene qPCR primer pairs and template standards for NAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for NAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT1
      QuantiTect SYBR Green Assays in human, mouse, rat NAT1
      QuantiFast Probe-based Assays in human, mouse, rat NAT1

    Additional mRNA sequence: 

    AJ581135.1 AJ581136.1 AJ581137.1 AJ581138.1 AJ581139.1 AJ581140.1 AJ581141.1 AJ581142.1 
    AJ581143.1 AJ581151.2 AJ581153.1 AJ581154.1 AJ581155.1 AK290912.1 BC013732.1 BC047666.1 
    BX647521.1 D90041.1 S78829.1 

    10 DOTS entries:

    DT.95269815  DT.212955  DT.121491296  DT.75190644  DT.121491283  DT.100746983  DT.40261666  DT.92018326 
    DT.97824906  DT.121491295 

    Selected AceView cDNA sequences (see all 65):

    BG941635 CR596299 BQ024509 NM_000662 BQ231158 D78248 BF594441 BM926650 
    BC047666 BG654454 CD511345 BM924372 BF034718 BX112361 D90041 BC013732 
    T29485 AI022585 BG656530 AI888631 BX647521 BU753390 BU689480 CB852436 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAT1 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:        -     -     -     -     -     -                                                   
    SP2:                    -     -     -     -                                                   
    SP3:                    -     -                 -                                             
    SP4:                                -     -     -                                             
    SP5:                                      -     -                                             


    ECgene alternative splicing isoforms for NAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTTCTGT
    NAT1 Expression
    About this image


    NAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             253G4
     
     Heart (Cardiovascular System)
    NAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591847
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NAT1: 
              Cancer Drug Resistance in human mouse rat
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for NAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAT1
    QuantiTect SYBR Green Assays in human, mouse, rat NAT1
    QuantiFast Probe-based Assays in human, mouse, rat NAT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NAT1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nat21 , 5 N-acetyltransferase 2 (arylamine N-acetyltransferase)1, 5 83.22(n)1
    82.07(a)1
      8 (33.38 cM)5
    179611  NM_001168577.11  NP_001162049.11 
     674948755 
    chicken
    (Gallus gallus)
    Aves PNAT101 N-acetyltransferase, pineal gland isozyme NAT-10 64.02(n)
    57.93(a)
      396283  NM_205340.1  NP_990671.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    53(a)
    1 → many
    GL343663.1(8584-9450)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7943811 arylamine N-acetyltransferase, pineal gland isozyme more 52.28(n)
    43.15(a)
      794381  XM_005169022.1  XP_005169079.1 


    ENSEMBL Gene Tree for NAT1 (if available)
    TreeFam Gene Tree for NAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAT1 gene
    NAT22  
    1 SIMAP similar gene for NAT1 using alignment to 7 protein entries:     ARY1_HUMAN (see all proteins):
    NAT2

    Find genes that share paralogs with NAT1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NAT1
    PGOHUM00000260428


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    ARY1_HUMAN, P18440: N-acetylation polymorphism is determined by a low or high NAT activity in liver and has been
    implicated in the action and toxicity of amine-containing drugs. Slow acetylation genotypes have been associated
    with significant lung cancer risk. Candidate risk factor for susceptibility to neural tube defects. The NAT1*10
    allele has been associated with increased risk of colon and urinary bladder cancers and with higher levels of
    N-acetyltransferase activity and DNA adducts in aromatic amine tumor target organs such as colon and urinary
    bladder


    Selected SNPs for NAT1 (see all 1756)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49870761,2,,4
    C,F,Hpathogenic118334871(+) CTTGTG/ATCTTC 18 /I /V mis1 ese319Minor allele frequency- A:0.01MN NA NS EA EU 7495
    rs2012802041,2
    C--16572706(+) TCTCCC/TTTTTT 1 -- int10--------
    rs743653021,2
    C--16604664(+) TAGAAG/-GGGGG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs339257131,2
    C--16617895(+) TTTTT-/TGCATA 8 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs2012417161,2
    --16619140(+) GTTAA-/TTTACTC 8 -- int10--------
    rs65867151,2
    C,F,A--16619747(+) tcctgT/Ctatag 8 -- int114Minor allele frequency- C:0.41NA NS WA CSA EA 1210
    rs65867161,2
    C,F,A--16619748(+) cctgcC/Tataga 8 -- int18Minor allele frequency- T:0.41NA NS WA CSA EA 546
    rs3722168181,2
    F--16624967(+) aataa-/TAATAAAT 18 -- ut311Minor allele frequency- TAA:0.02NS 170
    rs100980431,2
    C,F,H--18034497(+) tgagaT/Ctattt 1 -- int18Minor allele frequency- C:0.11NS EA WA CSA 540
    rs583452831,2
    C--18042561(+) GTTTC-/GGTTTCAGG
    AGTGCTTGTTTC
    AGTTT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for NAT1 (18027986 - 18081198 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666024CNV Deletion23128226
    nsv831251CNV Loss17160897
    nsv890598CNV Loss21882294
    nsv522647CNV Loss19592680
    nsv890597CNV Gain21882294
    nsv428196CNV Gain18775914
    nsv890599CNV Gain21882294

    Human Gene Mutation Database (HGMD): NAT1
    Locus Specific Mutation Databases (LSDB): NAT1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for NAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108345    OMIM disorders: --

    7 diseases for NAT1:    
    About MalaCards
    orthostatic intolerance    multiple chemical sensitivity    drug-induced hepatitis    talipes equinovarus
    spina bifida    neural tube defects    non-hodgkin lymphoma

    1 disease from the University of Copenhagen DISEASES database for NAT1:
    Urinary bladder cancer

    Find genes that share disorders with NAT1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for NAT1 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder cancer 70.9 38 11431340 (4), 9107426 (4), 14564055 (4), 17026750 (2) (see all 17)
    colorectal cancer 54 38 16434594 (5), 7627961 (4), 9528834 (3), 15736440 (3) (see all 14)
    genetic susceptibility 51 5 18259988 (1), 10667461 (1), 12485520 (1)
    cancer 50.9 84 10667461 (5), 12351146 (3), 18259988 (2), 14672957 (2) (see all 48)
    breast cancer 27.7 51 20100460 (4), 12860276 (4), 10090301 (3), 17973251 (3) (see all 20)
    pancreatic cancer 25.6 14 15987714 (4), 18006927 (2), 9696930 (1), 11095579 (1) (see all 5)
    neural tube defects 25.6 2 10767335 (1)
    colon cancer 25.1 13 18022202 (4), 18569593 (2), 12568823 (1), 10493262 (1)
    lymphoblastic leukemia acute childhood 24.9 1 10868688 (1)
    cancer lung 22.9 17 9731715 (4), 9626964 (3), 16835348 (1), 18258609 (1) (see all 6)

    Genetic Association Database (GAD): NAT1
    Human Genome Epidemiology (HuGE) Navigator: NAT1 (248 documents)

    Export disorders for NAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAT1 gene, integrated from 10 sources (see all 423):
    (articles sorted by number of sources associating them with NAT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss of function polymorphisms in NAT1 protect against spina bifida. (PubMed id 16680433)1, 4, 9 Jensen L.E.... Whitehead A.S. (Hum. Genet. 2006)
    2. Para-phenylenediamine and allergic sensitization: risk modification by N-acetyltransferase 1 and 2 genotypes. (PubMed id 19663877)1, 4, 9 BlAPmeke B....Kawakubo Y. (Br. J. Dermatol. 2009)
    3. Characterization of N-acetyltransferase 1 and 2 polymorphisms and haplotype analysis for inflammatory bowel disease and sporadic colorectal carcinoma. (PubMed id 17537267)1, 4, 9 Mahid S.S....Galandiuk S. (BMC Med. Genet. 2007)
    4. Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China? (PubMed id 15770721)1, 4, 9 Zhang X.F....Tang B.M. (World J. Gastroenterol. 2005)
    5. Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations. (PubMed id 9511183)1, 2, 9 Butcher N.J.... Minchin R.F. (Pharmacogenetics 1998)
    6. NAT1 genotypes do not predict response to mesalamine in patients with ulcerative colitis. (PubMed id 18322880)1, 4, 9 Hausmann M....Rogler G. (Z Gastroenterol 2008)
    7. Modification by N-acetyltransferase 1 genotype on the association between dietary heterocyclic amines and colon cancer in a multiethnic study. (PubMed id 18022202)1, 4, 9 Butler L.M....Sandler R.S. (Mutat. Res. 2008)
    8. Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma. (PubMed id 16847422)1, 4, 9 Morton L.M....Wang S.S. (Pharmacogenet. Genomics 2006)
    9. Effect of NAT1 and NAT2 genetic polymorphisms on colorectal cancer risk associated with exposure to tobacco smoke and meat consumption. (PubMed id 16434594)1, 4, 9 Lilla C....Chang-Claude J. (amp 2006)
    10. Lack of association between endometriosis and N-acetyl transferase 1 (NAT1) and 2 (NAT2) polymorphisms in a Japanese population. (PubMed id 15784508)1, 4, 9 Deguchi M....Maruo T. (J. Soc. Gynecol. Investig. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9 HGNC: 7645 AceView: NAT1 Ensembl:ENSG00000171428 euGenes: HUgn9
    ECgene: NAT1 Kegg: 9 H-InvDB: NAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NAT1 Genetics and Cytogenetics in Oncology and Haematology
    NAThttp://www.louisville.edu/medschool/pharmacology/NAT.html
    NIEHS-SNPshttp://egp.gs.washington.edu/data/nat1/
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAT1 gene:
    Search GeneIP for patents involving NAT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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