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NAT1 Gene

protein-coding GIFtS: 66

GC08P018111

N-acetyltransferase 1 (arylamine N-acetyltransferase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: AAC1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AAC1 ^², ³, ⁵
EC 2.3.1.5 ^³
MNAT ^³
NAT-1 ^³
NATI ^²
OTTHUMP00000122488 ^²

Descriptions
Arylamide acetylase 1 ^³
Monomorphic arylamine N-acetyltransferase ^³
N-acetyltransferase 1 ^²
N-acetyltransferase 1 (arylamine N-acetyltransferase) ^²
N-acetyltransferase type 1 ^³

External Ids
HGNC: 7645¹
Entrez Gene: 9²
UniProtKB: P18440³
Ensembl: ENSG00000171428⁷

Search outside databases for aliases for NAT1 gene

Previous GC identifers: GC08P017943 GC08P018130 GC08P018077

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAT1:

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human geneome, and is

orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the

transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This

enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple

transcript variants encoding different isoforms have been found for this gene. [provided by

RefSeq]

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs.

Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is

able to bioactivate several known carcinogens

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAT1 gene

Entrez Gene cytogenetic band: 8p23.1-p21.3 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22

NAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P018111: (about GC identifiers)

Start:	18,111,895 bp from pter
End:	18,125,100 bp from pter
Size:	13,206 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_030737.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440 (See protein sequence)

Recommended Name: Arylamine N-acetyltransferase 1

Size: 290 amino acids; 33899 Da

Subcellular location: Cytoplasm

Miscellaneous: NAT1 was historically considered to be monomorphic in nature but reports of allelic

variations at the NAT1 locus suggest that it is a polymorphically expressed enzyme

Caution: The allelic variation Ile-149 designated as NAT1*17 is part of the NAT1*11 allelic

variation as reported by the nomenclature commitee

PDB structures from and Proteopedia :

2DSS (3D)

2GWU (3D)

2IJA (3D)

2PQT (3D)

Secondary accessions: A8K4E7 O15159 O15300 Q546N1 Q96TE9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (9 alternative transcripts):

NP_000653.3 NP_001153642.1 NP_001153643.1 NP_001153644.1 NP_001153645.1 NP_001153646.1 NP_001153647.1 NP_001153648.1

NP_001153651.1

ENSEMBL proteins:

ENSP00000307218

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NAT1)
	Human Recombinant Proteins from Abnova (NAT1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	1559981

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Antibodies for NAT1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NAT1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NAT1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NAT1)
	Novus Biologicals Antibodies for NAT1

Assays for NAT1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P18440

ProtoNet protein and cluster: P18440

1 Blocks protein family: IPB004081 Arylamine N-acetyltransferase signature

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Similarity: Belongs to the arylamine N-acetyltransferase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAT1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000662

Applied Biosystems Silencer® siRNAs for NAT1

Sigma-Aldrich siRNA for NAT1

Sigma-Aldrich shRNA for NAT1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAT1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000662
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000662
untagged cDNA clone in CMV expression vector: NM_000662

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000662

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Function: Participates in the detoxification of a plethora of hydrazine and arylamine drugs.

Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is

able to bioactivate several known carcinogens

Catalytic activity: Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine

Enzyme Number (IUBMB): EC 2.3.1.5

Genatlas biochemistry entry for NAT1:

arylamine N-acetyltransferase 1,widely expressed,monomorphic,also involved in bladder

carcinogenesis

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nat2):

homeostasis/metabolism

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004060	arylamine N-acetyltransferase activity	TAS	10908296
GO:0016407	acetyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for NAT1

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAT1
10/26 Novoseek chemical compound relationships for NAT1 gene (see all 26 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
arylamine	97.50	164	8861781 (6), 11436130 (3), 9511183 (2), 16829624 (2) (see all 82)
2-aminofluorene	89.61	10	16314733 (1), 16829624 (1), 8179482 (1), 9571233 (1) (see all 9)
p-acetamidobenzoylglutamate	80.81	3	9839355 (1), 11113560 (1)
n-hydroxy-2-aminofluorene	80.81	4	8425184 (3), 8353847 (1)
2-naphthylamine	77.13	1	8353847 (1)
phip	76.87	5	8179482 (1), 10381774 (1), 12618593 (1), 14601045 (1)
2-amino-3-methylimidazo(4,5-f)quinoline	72.94	3	16496416 (1), 8353847 (1), 1423830 (1)
n-hydroxy-2-acetylaminofluorene	70.75	5	8425184 (3), 15025497 (1), 8353847 (1)
meiqx	70.24	6	8179482 (1), 8012961 (1), 11875368 (1)
n-hydroxy phip	68.48	2	11505221 (1)

About this table

2 PharmGKB drug compound relationships for NAT1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
sulfamethoxazole	FA	7562475
xenobiotics	PK	9202739

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAT1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NAT1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000662

Sigma-Aldrich siRNA for NAT1

Sigma-Aldrich shRNA for NAT1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000662

REFSEQ mRNAs for NAT1 gene (9 alternative transcripts):

NM_000662.5 NM_001160170.1 NM_001160171.1 NM_001160172.1 NM_001160173.1 NM_001160174.1 NM_001160175.1 NM_001160176.1

NM_001160179.1

NM_000662

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000662
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000662
                                 untagged cDNA clone in CMV expression vector: NM_000662

Additional cDNA sequence:

AJ581135.1 AJ581136.1 AJ581137.1 AJ581138.1 AJ581139.1 AJ581140.1 AJ581141.1 AJ581142.1

AJ581143.1 AJ581151.2 AJ581153.1 AJ581154.1 AJ581155.1 AK290912.1 BC013732.1 BC047666.1

BX647521.1 CR596299.1 D90041.1 S78829.1

10 DOTS entries:

DT.95269815 DT.212955 DT.121491296 DT.75190644 DT.121491283 DT.100746983 DT.40261666 DT.92018326

DT.97824906 DT.121491295

24/65 AceView cDNA sequences (see all 65 ):

BQ231158 BF594441 CR596299 BM926650 D78248 BG941635 NM_000662 BQ024509

BF034718 BC047666 BG654454 BM924372 T29485 D90041 BU753390 CB852436

AI022585 AI888631 BU689480 BX112361 BX647521 BC013732 CD511345 BG656530

highest scoring ESTs for NAT1:

D90041 AA721180 AA913774 AI022585 AI204592 AI673244 AI861954 AI888631 AW071050 AW071587

Unigene Cluster for NAT1:

N-acetyltransferase 1 (arylamine N-acetyltransferase)

Hs.591847 [show with all ESTs]

Unigene Representative Sequence: BC013732

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NAT1 (see all 9 )

ExUns:	1	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	·	7f
SP1:			-		-		-		-		-		-
SP2:							-		-		-		-
SP3:							-		-						-
SP4:											-		-		-
SP5:													-		-

About this scheme

ECgene alternative splicing isoforms for NAT1

1 Ensembl transcript including schematic representation:

ENST00000307719

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAT1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAT1

¹ / ² / ³

4 probe-sets matching NAT1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
66045_at²^{, 3}	U95-C	1	1.00	1.00	0.87	1.01	AI673244	0.80	1.00	0.91	1
38187_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.01	D90041	1.00	1.00	1.00	1
214440_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000662	0.60	1.00	0.82	1
214440_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NAT1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATCTTCTGT

SOURCE GeneReport for Unigene cluster: Hs.591847
Expression variation in blood from EXPOLDB for NAT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAT1 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	NAT1¹	--	N-acetyltransferase 1 (arylamine N-acetyltransferase)	98.51(n) 97.93(a)	464023 XM_519630.2 XP_519630.1
cow (Bos taurus)	NAT1¹	--	N-acetyltransferase 1 (arylamine N-acetyltransferase)	84.48(n) 82.76(a)	512603 NM_001075572.1 NP_001069040.1
rat (Rattus norvegicus)	Nat2¹	--	N-Acetyltransferase-2 (arylamine N-acetyltransferase)	83.91(n) 81.38(a)	116632 NM_053854.1 NP_446306.1
mouse (Mus musculus)	Nat2^{1, 5}	8 (31.00 cM)⁵	N-acetyltransferase 2 (arylamine N-acetyltransferase)^{1, 5}	83.22(n)¹ 82.07(a)¹	17961¹ NM_010874.2¹ NP_035004.1¹ AJ250123⁵ AJ251710⁵ (see all 17)
chicken (Gallus gallus)	NAT1¹	--	N-acetyltransferase 1 (arylamine N-acetyltransferase)	64.02(n) 57.93(a)	396283 NM_205340.1 NP_990671.1

About this table Species with no ortholog for NAT1

ENSEMBL Gene Tree for NAT1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NAT1 gene

NAT2²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ARY1_HUMAN, P18440

Polymorphism: N-acetylation polymorphism is determined by a low or high NAT activity in liver and

has been implicated in the action and toxicity of amine-containing drugs. Slow acetylation

genotypes have been associated with significant lung cancer risk. Candidate risk factor for

susceptibility to neural tube defects. The NAT1*10 allele has been associated with increased risk

of colon and urinary bladder cancers and with higher levels of N-acetyltransferase activity and

DNA adducts in aromatic amine tumor target organs such as colon and urinary bladder

10/231 NCBI SNPs in NAT1 are shown (see all 231 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 155)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs15561^1,2	A,C,F,H	18124931(+)	`AATGTC/ATTTTA`	1	--	ut3¹		16	MN CSAM EA NS EU WA NA	1648
	rs11203942^1,2	A,C,F,H	18110372(+)	`CAGTAC/GTCATT`	1	--	ng5¹		5	EU EA WA NS	596
	rs8190870^1,2	A,C,F,H	18125552(+)	`GTGTGC/TTCTGT`	1	--	ng3¹		19	NS NA EU EA WA	1974
	rs6586712^1,2	A,C,F,H	18111247(+)	`tattgT/Ggtcaa`	1	--	ng5¹		5	EU EA WA NS	558
--	rs4986993^1,2	A,C,F,H	18125027(+)	`TTTATG/TGGTAG`	1	--	ut3¹ ese³		18	MN CSAM EA NS EU WA NA	1728
	rs10888150^1,2	A,C,F,H	18110406(+)	`ACAAAT/CATCCT`	1	--	ng5¹		19	EU EA WA NS	2090
	rs1907951^1,2	C,F,H	18125409(-)	`CTGACG/ATTATT`	1	--	ng3¹ ese³		5	NS EU EA WA	600
	rs4987195^1,2	C,F,H	18124456(+)	`GAATAC/TATACC`	1	T/I	mis¹ ese³		9	MN CSAM EA EU WA	820
--	rs8190867^1,2	C,F,H	18125521(+)	`TGATAG/AGATAT`	1	--	ng3¹		6	NS EU EA WA	768
--	rs6981591^1,2	A,C,F	18109931(+)	`gggagG/Agagcg`	1	--	ng5¹ tfbs³ trp³		4	NA NS	316

About this table

HapMap Linkage Disequilibrium images for NAT1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 108345

10/36 Novoseek disease relationships for NAT1 gene (see all 36 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bladder cancer	71.14	38	11431340 (4), 9107426 (4), 14564055 (4), 17026750 (2) (see all 17)
colorectal cancer	55.74	38	16434594 (5), 7627961 (4), 9528834 (3), 15736440 (3) (see all 14)
cancer	51.56	76	10667461 (5), 12351146 (3), 18259988 (2), 14672957 (2) (see all 44)
genetic susceptibility	49.45	5	18259988 (1), 10667461 (1), 12485520 (1)
pancreatic cancer	27.81	14	15987714 (4), 18006927 (2), 9696930 (1), 11095579 (1) (see all 5)
colon cancer	27.00	13	18022202 (4), 18569593 (2), 12568823 (1), 10493262 (1)
neural tube defects	26.85	2	10767335 (1)
lymphoblastic leukemia acute childhood	26.79	1	10868688 (1)
breast cancer	25.52	45	12860276 (4), 10090301 (3), 17973251 (3), 15090724 (3) (see all 17)
cancer lung	24.83	17	9731715 (4), 9626964 (3), 16835348 (1), 18258609 (1) (see all 6)

About this table

1 PharmGKB disease relationship for NAT1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
sulfamethoxazole idiosyncratic adverse drug reactions	FA	7562475

About this table

Human Gene Mutation Database: NAT1
Genetic Association Database: NAT1
Human Genome Epidemiology Navigator: NAT1 (176 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

AACR: Genetic Connection In Link Between Permanent Hair Dye Use And Bladder Cancer Risk

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/341 PubMed articles for NAT1 gene (see all 341 ):

Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations. (PubMed id 9511183)^{1, 3, 4} Butcher N.J.... Minchin R.F. (1998)
NAT gene polymorphisms and susceptibility to Alzheimer's disease: identification of a novel NAT1 allelic variant. (PubMed id 15142281)^{1, 3, 6} Johnson N....Sim E. (2004)
Effects of N-acetyl transferase 1 and 2 polymorphisms on bladder cancer risk in Caucasians. (PubMed id 15725609)^{1, 3, 6} Gu J....Wu X. (2005)
N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer. (PubMed id 12860276)^{1, 3, 6} Lee K.M....Kang D. (2003)
Association of prostate cancer with rapid N-acetyltransferase 1 (NAT1*10) in combination with slow N-acetyltransferase 2 acetylator genotypes in a pilot case-control study. (PubMed id 12355549)^{1, 3, 6} Hein D.W....Caporaso N.E. (2002)
[The research the relationship between N-acetyltransferase 1 gene polymorphisms and genetic susceptibility to sporadic colorectal adenocarcinoma] (PubMed id 12485520)^{1, 3, 6} Zhang Y....Zhou Y. (2002)
Association of arylamine N-acetyltransferase (NAT1 and NAT2) genotypes with urinary bladder cancer risk. (PubMed id 14564055)^{1, 3, 6} Jaskul/a-Sztul R....Szyfter K. (2001)
Association of NAT1 and NAT2 polymorphisms to urinary bladder cancer: significantly reduced risk in subjects with NAT1*10. (PubMed id 11431340)^{1, 3, 6} Cascorbi I....Brockmoller J. (2001)
Structural heterogeneity of Caucasian N-acetyltransferase at the NAT1 gene locus. (PubMed id 8442668)^{1, 3, 4} Vatsis K.P. and Weber W.W. (1993)
Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer. (PubMed id 15987714)^{1, 3, 6} Li D....Hassan M.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9	HGNC: 7645	AceView: NAT1	Ensembl:ENSG00000171428	euGenes: HUgn9
ECgene: NAT1	H-InvDB: NAT1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for NAT1	Genetics and Cytogenetics in Oncology and Haematology
NAT	http://www.louisville.edu/medschool/pharmacology/NAT.html
NIEHS-SNPs	http://egp.gs.washington.edu/data/nat1/
SHMPD	http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=NAT1

Licensable Technologies for NAT1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAT1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAT1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAT1		Antibodies for NAT1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAT1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAT1)
	Antibodies (NAT1)
	Chimera RNAi (NAT1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (NAT1)
	Antibodies (NAT1)

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Antibodies for NAT1

GeneCards Homepage - Last full update: 1 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
NAT1 Gene at Home site.
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NAT1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for NAT1

Summaries
for NAT1

Genomic Location
for NAT1

Proteins
for NAT1

Protein Domains/
Families
for NAT1

Gene Function
for NAT1

Pathways & Interactions
for NAT1

Drugs & Compounds
for NAT1

Transcripts
for NAT1

Expression
for NAT1

Orthologs
for NAT1

Paralogs
for NAT1

SNPs/Variants
for NAT1

Disorders & Mutations
for NAT1

Medical News
for NAT1

Publications
for NAT1

Search for NAT1

Genome Databases showing NAT1

Other Databases showing NAT1

Specialized Databases showing NAT1

Licensable Technologies
for NAT1

Services
for NAT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAT1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor NAT1

Summariesfor NAT1

Genomic Locationfor NAT1

Proteinsfor NAT1

Protein Domains/Familiesfor NAT1

Gene Functionfor NAT1

Pathways & Interactionsfor NAT1

Drugs & Compoundsfor NAT1

Transcriptsfor NAT1

Expression for NAT1

Orthologsfor NAT1

Paralogsfor NAT1

SNPs/Variantsfor NAT1

Disorders & Mutationsfor NAT1

Medical Newsfor NAT1

Publicationsfor NAT1

Search for NAT1

Genome Databases showing NAT1

Other Databases showing NAT1

Specialized Databases showing NAT1

Licensable Technologiesfor NAT1

Servicesfor NAT1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAT1

Summaries
for NAT1

Genomic Location
for NAT1

Proteins
for NAT1

Protein Domains/
Families
for NAT1

Gene Function
for NAT1

Pathways & Interactions
for NAT1

Drugs & Compounds
for NAT1

Transcripts
for NAT1

Expression
for NAT1

Orthologs
for NAT1

Paralogs
for NAT1

SNPs/Variants
for NAT1

Disorders & Mutations
for NAT1

Medical News
for NAT1

Publications
for NAT1

Licensable Technologies
for NAT1

Services
for NAT1