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NASP Gene

protein-coding   GIFtS: 54
GCID: GC01P046049

Nuclear Autoantigenic Sperm Protein (Histone-Binding)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Autoantigenic Sperm Protein (Histone-Binding)1 2
FLB75272
PRO19992
Histone H1-Binding Protein2
Nuclear Autoantigenic Sperm Protein2

External Ids:    HGNC: 76441   Entrez Gene: 46782   Ensembl: ENSG000001327807   OMIM: 6031855   UniProtKB: P493213   

Export aliases for NASP gene to outside databases

Previous GC identifers: GC08M061216 GC01P045050 GC01P045479 GC01P045463 GC01P045718 GC01P045823 GC01P044161


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NASP Gene:
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of
dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed
in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is
expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the
cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature
spermatozoa. (provided by RefSeq, Jul 2008)

GeneCards Summary for NASP Gene:
NASP (nuclear autoantigenic sperm protein (histone-binding)) is a protein-coding gene. GO annotations related to this gene include Hsp90 protein binding and histone binding.

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic
complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are
subsequently released from the complex and translocate to the nucleus where the histone is released for binding
to DNA (By similarity)

Gene Wiki entry for NASP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NASP gene promoter:
         Pax-5   Sp1   AP-4   C/EBPalpha   CHOP-10   AREB6   HFH-1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNASP promoter sequence
   Search Chromatin IP Primers for NASP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NASP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

NASP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NASP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046049:  view genomic region     (about GC identifiers)

Start:
46,049,518 bp from pter      End:
46,084,578 bp from pter
Size:
35,061 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NASP_HUMAN, P49321 (See protein sequence)
Recommended Name: Nuclear autoantigenic sperm protein  
Size: 788 amino acids; 85238 Da
Subunit: Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This
interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity)
Secondary accessions: A8K6H2 B4DQP3 D3DQ07 F5H3J2 Q53GW5 Q5T622 Q5T625 Q96A69 Q9BTW2
Alternative splicing: 4 isoforms:  P49321-1   P49321-2   P49321-3   P49321-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NASP: NX_P49321

Explore proteomics data for NASP at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys52, Lys93, Lys535, Lys643, Lys657, Lys671, Lys698
  • Modification sites at PhosphoSitePlus

  • See NASP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001182122.1  NP_002473.2  NP_689511.2  

    ENSEMBL proteins: 
     ENSP00000400792   ENSP00000388010   ENSP00000435363   ENSP00000436790   ENSP00000435548  
     ENSP00000436778   ENSP00000436388   ENSP00000437241   ENSP00000436939   ENSP00000403157  
     ENSP00000432289   ENSP00000255120   ENSP00000436924   ENSP00000361122   ENSP00000255121  
     ENSP00000437116   ENSP00000434240   ENSP00000438871   ENSP00000384529  

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    Novus Biologicals NASP Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for NASP

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR019544 Tetratricopeptide_SHNi-TPR_dom
     IPR001440 TPR_1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P49321

    ProtoNet protein and cluster: P49321

    UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
    Similarity: Belongs to the NASP family
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with NASP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NASP_HUMAN, P49321
    Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic
    complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are
    subsequently released from the complex and translocate to the nucleus where the histone is released for binding
    to DNA (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042393histone binding IEA--
    GO:0051879Hsp90 protein binding ISS--
         
    Find genes that share ontologies with NASP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NASP:
     Increased cell death in breast 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nasp):
     embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with NASP           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Nasptm1Mgor for NASP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NASP
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NASP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NASP

    miRNA
    Products:
        
    miRTarBase miRNAs that target NASP:
    hsa-mir-24-3p (MIRT030415), hsa-mir-124-3p (MIRT022289), hsa-mir-29a-3p (MIRT006250), hsa-mir-93-3p (MIRT038742), hsa-mir-186-5p (MIRT045140), hsa-mir-155-5p (MIRT020617), hsa-mir-34a-5p (MIRT025284), hsa-mir-29b-3p (MIRT006251), hsa-mir-484 (MIRT041894)

    Block miRNA regulation of human, mouse, rat NASP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NASP (see all 18):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-3616-5p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-3653 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidNASP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NASP

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    GenScript: all cDNA clones in your preferred vector (see all 3): NASP (NM_152298)
    Sino Biological Human cDNA Clone for NASP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NASP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NASP

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NASP_HUMAN, P49321: Cytoplasm (By similarity). Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum2
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with NASP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NASP
    Interactions:

        Search GeneGlobe Interaction Network for NASP

    Selected Interacting proteins for NASP (P493212, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4BP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4CP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4DP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4EP628052, 3MINT-7220359 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development ISS--
    GO:0006260DNA replication ISS--
    GO:0007049cell cycle ISS--
    GO:0008283cell proliferation ISS--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with NASP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NASP



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NASP gene (4 alternative transcripts): 
    NM_001195193.1  NM_002482.3  NM_152298.3  NM_172164.1  

    Unigene Cluster for NASP:

    Nuclear autoantigenic sperm protein (histone-binding)
    Hs.319334  [show with all ESTs]
    Unigene Representative Sequence: AY700118
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000437901 ENST00000437362 ENST00000464190 ENST00000528084 ENST00000527359
    ENST00000530840 ENST00000531532 ENST00000529333 ENST00000527470 ENST00000525515
    ENST00000453748(uc001cok.2 uc010olq.2) ENST00000528238 ENST00000534101
    ENST00000350030(uc001coi.2 uc001coj.2 uc010olr.2) ENST00000470768
    ENST00000372052 ENST00000351223 ENST00000530073
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NASP (see all 18):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-3616-5p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-3653 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidNASP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NASP
    Predesigned siRNA for gene silencing in human, mouse, rat NASP
    Clone
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    OriGene ORF clones in mouse, rat for NASP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NASP (NM_152298)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NASP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NASP
    Primer
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    OriGene qPCR primer pairs and template standards for NASP
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NASP
      QuantiTect SYBR Green Assays in human, mouse, rat NASP
      QuantiFast Probe-based Assays in human, mouse, rat NASP

    Additional mRNA sequence: 

    AF035191.1 AK056161.1 AK131249.1 AK222778.1 AK222816.1 AK291637.1 AK298893.1 AK299584.1 
    AK308001.1 AL512718.1 AY700118.1 BC003113.1 BC009933.2 BC010105.2 BC011580.1 BC053608.1 
    BT006757.1 M97856.1 

    Selected DOTS entries (see all 45):

    DT.92460539  DT.92460525  DT.100032703  DT.87016487  DT.92460535  DT.100665291  DT.91887358  DT.100856779 
    DT.100038627  DT.92460531  DT.100863204  DT.102838067  DT.121343899  DT.121343702  DT.100665287  DT.97860848 
    DT.121343839  DT.40219355  DT.100670180  DT.121343898  DT.92460537  DT.102838070  DT.75110901  DT.95378235 

    Selected AceView cDNA sequences (see all 683):

    CK300084 BG681133 AW590956 AI963998 BQ940191 BQ008419 BE300849 BE397353 
    BU931111 BU688779 CD366592 BP873580 BF975875 BF001269 BE671829 BM457493 
    NM_172164 AU127400 NM_152298 BC010105 AV704204 BM718227 CR615803 BX098924 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NASP (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^
    SP1:                          -     -                             -                       -           -                 -                                   -   
    SP2:                          -     -                             -     -     -     -     -           -                 -                                   -   
    SP3:                          -                                   -                       -           -                 -                                       
    SP4:                          -                                   -     -     -     -     -           -                                                         
    SP5:                          -     -     -     -     -     -     -     -     -     -     -           -                 -                                       

    ExUns: 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for NASP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NASP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGAGGGG
    NASP Expression
    About this image


    NASP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Uterus (Reproductive System)
    NASP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NASP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.319334

    UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
    Tissue specificity: Isoform 1 is testis- and sperm-specific

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    QuantiFast Probe-based Assays in human, mouse, rat NASP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NASP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NASP gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nasp1 , 5 nuclear autoantigenic sperm protein (histone-binding)1, 5 86.91(n)1
    82.96(a)1
      4 (53.24 cM)5
    509271  NM_016777.31  NP_058057.31 
     1166010525 
    chicken
    (Gallus gallus)
    Aves NASP6
    nuclear autoantigenic sperm protein (histone-bindi...
    53(a)
    1 ↔ 1
    8(20075622-20085978)
    lizard
    (Anolis carolinensis)
    Reptilia NASP6
    nuclear autoantigenic sperm protein (histone-bindi...
    48(a)
    1 ↔ 1
    4(110130810-110148325)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979012 Xenopus laevis mRNA for histone-binding protein N1/N2 75.25(n)    X04712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd20g122 wufd20g12 76.13(n)   327300  BC045857.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82236
    --
    23(a)
    1 ↔ 1
    3R(4573528-4581638)
    worm
    (Caenorhabditis elegans)
    Secernentea nasp-16
    nasp-26
    Protein NASP-2 (nasp-2) mRNA, complete cds
    28(a)
    23(a)
    many → 1
    many → 1
    II(11106616-11108177) WBGene00007500
    V(13310184-13312260) WBGene00008218


    ENSEMBL Gene Tree for NASP (if available)
    TreeFam Gene Tree for NASP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NASP gene
    1 SIMAP similar gene for NASP using alignment to 16 protein entries:     NASP_HUMAN (see all proteins):
    ADAT1

    Find genes that share paralogs with NASP           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NASP
    PGOHUM00000258344


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NASP (see all 881)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674364171,2
    C--44163852(+) AGAAA-/TAAA  
            
    CCTCA
    3 -- int11Minor allele frequency- TAAA:0.50NA 2
    rs669876041,2
    C--44165971(+) TCAAGTGTT/-  
            
    TGTTT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs561813551,2
    C--44165994(+) TTTGT-/TTGT  
            
    GAGTG
    3 -- int11Minor allele frequency- TTGT:0.00NA 2
    rs611343951,2
    C--46048758(+) GGGGGG/-TCTCA 3 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2011538201,2
    --46050003(+) TCGCT-/GTTC  
            
    GGGAA
    3 -- int10--------
    rs572575301,2
    C--46050005(+) GCTGT-/TCGG  
            
    GAAGG
    3 -- int12Minor allele frequency- TCGG:0.00NA CSA 4
    rs725186071,2
    C--46051912(+) GTGCC-/GTGTGTGT
    GTGTGTGTGT
    GTGTG
    3 -- int10--------
    rs57738851,2
    C--46051956(+) tgtgt-/Ggtgtg 3 -- int10--------
    rs752935551,2
    --46054653(+) TTTGTG/TTGTGA 3 -- int10--------
    rs801397721,2
    C--46054654(+) TTGTTA/TGTGAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for NASP (46049518 - 46084578 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NASP:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273688CNV Insertion20981092
    nsv829726CNV Loss17160897
    nsv871928CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NASP
    DNA2.0 Custom Variant and Variant Library Synthesis for NASP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603185    OMIM disorders: --


    Find genes that share disorders with NASP           About GenesLikeMe


    Export disorders for NASP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NASP gene, integrated from 10 sources (see all 79):
    (articles sorted by number of sources associating them with NASP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. (PubMed id 1426632)1, 2, 3, 9 O'Rand M.G.... Widgren E.E. (Dev. Biol. 1992)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Histone-binding domains in a human nuclear autoantigenic sperm protein. (PubMed id 8724350)1, 2 Batova I. and O'Rand M.G. (Biol. Reprod. 1996)
    8. Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. (PubMed id 19439102)1, 9 Alekseev O.M....O'Rand M.G. (amp 2009)
    9. Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. (PubMed id 10893414)1, 9 Richardson R.T....O'Rand M.G. (J. Biol. Chem. 2000)
    10. Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. (PubMed id 16728391)1, 9 Richardson R.T....O'Rand M.G. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4678 HGNC: 7644 AceView: NASP Ensembl:ENSG00000132780 euGenes: HUgn4678
    ECgene: NASP H-InvDB: NASP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NASP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NASP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NASP gene:
    Search GeneIP for patents involving NASP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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