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NASP Gene

protein-coding GIFtS: 56

GC01P045823

nuclear autoantigenic sperm protein (histone-binding)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp547F162 ^¹, ²
FLB7527 ^¹, ²
FLJ31599 ^¹, ²
FLJ35510 ^¹, ²
MGC19722 ^¹, ²
MGC20372 ^¹, ²
MGC2297 ^¹, ²
N1/N2-like ^²
OTTHUMP00000009509 ^²
OTTHUMP00000009513 ^²
PRO1999 ^¹, ²

Descriptions
histone H1-binding protein ^²
nuclear autoantigenic sperm protein ^²
nuclear autoantigenic sperm protein (histone-binding) ^²

External Ids
HGNC: 7644¹
Entrez Gene: 4678²
UniProtKB: P49321³
Ensembl: ENSG00000132780⁷

Search outside databases for aliases for NASP gene

Previous GC identifers: GC08M061216 GC01P045050 GC01P045479 GC01P045463 GC01P045718

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NASP:

This gene encodes a H1 histone binding protein that is involved in transporting histones into the

nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The

somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the

cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In

male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus

of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq]

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321

Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms

a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP

and H1 histone are subsequently released from the complex and translocate to the nucleus where the

histone is released for binding to DNA (By similarity)

Gene Wiki entry for NASP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NASP gene

Entrez Gene cytogenetic band: 1p34.1 Ensembl cytogenetic band: 1p34.1 HGNC cytogenetic band: 1p34.1

NASP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P045823: (about GC identifiers)

Start:	45,822,304 bp from pter
End:	45,857,154 bp from pter
Size:	34,851 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321 (See protein sequence)

Recommended Name: Nuclear autoantigenic sperm protein

Size: 788 amino acids; 85238 Da

Subunit: Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the

cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity)

Subcellular location: Cytoplasm (By similarity). Nucleus

Secondary accessions: Q53GW5 Q5T622 Q5T625 Q96A69 Q9BTW2

Alternative splicing: 3 isoforms: P49321-1 P49321-2 P49321-3

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_002473.2 NP_689511.2 NP_751896.1

ENSEMBL proteins:

ENSP00000345532 ENSP00000255120 ENSP00000361122 ENSP00000384529 ENSP00000255121

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NASP)
	Human Recombinant Proteins from Abnova (NASP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for NASP:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NASP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for NASP

Assays for NASP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P49321

ProtoNet protein and cluster: P49321

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321

Similarity: Belongs to the NASP family

Similarity: Contains 3 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NASP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_152298

Applied Biosystems Silencer® siRNAs for NASP

Sigma-Aldrich siRNA and siRNA Panels for NASP

Sigma-Aldrich shRNA for NASP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NASP
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002482
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002482
untagged cDNA clones in CMV expression vector (see all 6): BC003113

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_172164

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321

Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms

a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP

and H1 histone are subsequently released from the complex and translocate to the nucleus where the

histone is released for binding to DNA (By similarity)

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nasp):

embryogenesis

growth/size

lethality-prenatal/perinatal

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931
GO:0051879	Hsp90 protein binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Interacting proteins for NASP (ENSP00000345532³ P49321¹) via UniProtKB, MINT, and/or STRING (see all 6 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRAF6	Q9Y4K3¹	EBI-716205, EBI-359276
HSP90AA2	ENSP00000335153³	STRING (score=.884)
HIST1H1T	ENSP00000341214³	STRING (score=.844)
HIST1H1C	ENSP00000339566³	STRING (score=.828)
HIST1H1A	ENSP00000244573³	STRING (score=.825)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001824	blastocyst development	ISS	--
GO:0006260	DNA replication	ISS	--
GO:0007049	cell cycle	ISS	--
GO:0008283	cell proliferation	ISS	--
GO:0015031	protein transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NASP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NASP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_152298

Sigma-Aldrich siRNA and siRNA Panels for NASP

Sigma-Aldrich shRNA for NASP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002482 NM_152298 NM_172164

REFSEQ mRNAs for NASP gene (3 alternative transcripts):

NM_002482.2 NM_152298.2 NM_172164.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002482 NM_152298 NM_172164

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002482
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002482
                                 untagged cDNA clones in CMV expression vector (see all 6): BC003113

Additional cDNA sequence:

AF035191.1 AK056161.1 AK128017.1 AK131249.1 AK222778.1 AK222816.1 AK291637.1 AK298893.1

AK299584.1 AK308001.1 AL512718.1 AY700118.1 BC003113.1 BC009933.2 BC010105.2 BC011580.1

BC053608.1 BT006757.1 CR601103.1 CR601591.1 CR605878.1 CR611251.1 CR614144.1 CR615803.1

CR619825.1 CR621701.1 M97856.1

24/45 DOTS entries (see all 45 ):

DT.92460539 DT.92460525 DT.100032703 DT.87016487 DT.92460535 DT.100665291 DT.100856779 DT.91887358

DT.100038627 DT.92460531 DT.100863204 DT.102838067 DT.121343899 DT.121343702 DT.100665287 DT.97860848

DT.121343839 DT.40219355 DT.100670180 DT.121343898 DT.92460537 DT.102838070 DT.40227049 DT.75110901

24/683 AceView cDNA sequences (see all 683 ):

BM905897 AI797366 NM_002482 BM907292 CR615803 BG681133 BQ940191 BE250994

AW590956 BI117771 BF001269 BU507880 BM469674 AU132039 CR601591 BU931652

BX425926 BG259487 BM478535 AI130879 BG393355 NM_152298 BU150526 BU183796

highest scoring ESTs for NASP:

AW003362 M97856 AA169454 AA196494 AA199870 AA205539 AA213846 AA224373 AA232096 AA558419

Unigene Cluster for NASP:

Nuclear autoantigenic sperm protein (histone-binding)

Hs.319334 [show with all ESTs]

Unigene Representative Sequence: AY700118

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NASP (see all 13 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b	·	8c	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	·	13d	^
SP1:									-		-										-								-				-						-												-
SP2:									-		-										-		-		-		-		-				-						-												-
SP3:									-												-								-				-						-
SP4:									-												-		-		-		-		-				-
SP5:									-		-		-		-		-		-		-		-		-		-		-				-						-

ExUns:	14	^	15	^	16	^	17a	·	17b	·	17c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NASP

5 Ensembl transcripts including schematic representations:

ENST00000341288 ENST00000350030 ENST00000372052 ENST00000402363 ENST00000351223

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NASP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NASP

¹ / ² / ³

10 probe-sets matching NASP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
88526_at²^{, 3}	U95-E	1	1.00	1.00	0.85	1.10	AW003362	1.00	1.00	1.00	1
33255_at²^{, 3}	U95-A	1	1.00	1.00	0.83	1.00	M97856	1.00	1.00	1.00	1
89123_at²^{, 3}	U95-D	1	0.62	1.00	0.31	1.34	AI742380	0.60	1.00	0.82	1
72429_at*²^{, 3}	U95-D	1	0.81	1.00	-0.24	0.58	AI918171	0.60	1.00	0.82	1
201969_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW003362	1.00	1.00	1.00	1
201970_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002482	0.60	1.00	0.82	1
242918_at*²^{, 3}	U133-B	1	0.46	1.00	--	--	AU144734	0.40	1.00	0.76	1
201969_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201970_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
242918_at*²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

GeneDecks NASP for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTAAGAGGGG

SOURCE GeneReport for Unigene cluster: Hs.319334
Expression variation in blood from EXPOLDB for NASP
UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
Tissue specificity: Isoform 1 is testis- and sperm-specific

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NASP gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NASP¹	--	nuclear autoantigenic sperm protein (histone-binding)	91.6(n) 88.8(a)	475373 XM_856568.1 XP_861661.1
chimpanzee (Pan troglodytes)	NASP¹	--	nuclear autoantigenic sperm protein (histone-binding)	99.87(n) 99.87(a)	741511 XM_001158731.1 XP_001158731.1
cow (Bos taurus)	NASP¹	--	nuclear autoantigenic sperm protein (histone-binding)	90.38(n) 87.63(a)	512427 NM_001038088.2 NP_001033177.2
rat (Rattus norvegicus)	Nasp¹	--	nuclear autoantigenic sperm protein (histone-binding)	86.24(n) 81.5(a)	298441 NM_001005543.1 NP_001005543.1
mouse (Mus musculus)	Nasp^{1, 5}	4 (56.50 cM)⁵	nuclear autoantigenic sperm protein (histone-binding)^{1, 5}	86.78(n)¹ 82.83(a)¹	50927¹ NM_016777.3¹ NP_058057.3¹ AF034610⁵ AF095722⁵ (see all 23)

About this table Species with no ortholog for NASP

ENSEMBL Gene Tree for NASP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/188 NCBI SNPs in NASP are shown (see all 188 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 59)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1053941^1,2	A,C,F,H,O	45856970(+)	`TTTGAG/TCTCTG`	3	--	ut3¹ ese³		8		MN NA EU EA WA	740
	rs3811434^1,2	C,F,H	45821838(+)	`AGATCA/GGTTCT`	3	--	ng5¹		8		EU EA WA	832
	rs2297652^1,2	C,F,H	45822158(+)	`AGGAGG/CTGTCT`	3	--	ng5¹		7		EA MN EU WA	3162
	rs1541131^1,2	A,C,F	45857521(+)	`GAAACA/GAGCCC`	3	--	ng3¹		4		NA EA	362
	rs34618000^1,2	C,F	45853567(-)	`TTAGTA/CCAGCT`	3	V/G	mis¹		5		NA EU EA WA	466
	rs1055414^1,2	C	45821776(-)	`GATTGG/TCTACA`	3	--	ng5¹ tfbs³		1		MN	184
	rs2297653^1,2	H	45853458(+)	`CAGAAT/CGGGTG`	3	T/M	mis¹		3		EA WA	298
--	rs11549647^1,2	H	45843225(+)	`AATGAG/TTGTGG`	3	E/D	mis¹		4		EU EA WA	404
--	rs12406225^1,2	H	45845634(+)	`AAAAGA/GAGAAG`	3	E/G	mis¹ int¹ trp³		4		EU EA WA	406
--	rs945178^1,2	O	45856648(+)	`CTAACA/GTGGAG`	3	--	ut3¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for NASP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603185

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/40 PubMed articles for NASP gene (see all 40 ):

Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. (PubMed id 1426632)^{1, 2, 3, 4} O'Rand M.G.... Widgren E.E. (1992)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Histone-binding domains in a human nuclear autoantigenic sperm protein. (PubMed id 8724350)^{3, 4} Batova I. and O'Rand M.G. (1996)
Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. (PubMed id 10893414)^{1, 3} Richardson R.T....O'Rand M.G. (2000)
Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. (PubMed id 16728391)^{1, 3} Richardson R.T....O'Rand M.G. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4678	HGNC: 7644	AceView: NASP	Ensembl:ENSG00000132780	euGenes: HUgn4678
ECgene: NASP	H-InvDB: NASP

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NASP	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NASP
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NASP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NASP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NASP		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NASP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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NASP Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for NASP

Summaries
for NASP

Genomic Location
for NASP

Proteins
for NASP

Protein Domains/
Families
for NASP

Gene Function
for NASP

Pathways & Interactions
for NASP

Drugs & Compounds
for NASP

Transcripts
for NASP

Expression
for NASP

Orthologs
for NASP

Paralogs
for NASP

SNPs/Variants
for NASP

Disorders & Mutations
for NASP

Medical News
for NASP

Publications
for NASP

Search for NASP

Genome Databases showing NASP

Other Databases showing NASP

Specialized Databases showing NASP

Licensable Technologies
for NASP

Services
for NASP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NASP Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor NASP

Summariesfor NASP

Genomic Locationfor NASP

Proteinsfor NASP

Protein Domains/Familiesfor NASP

Gene Functionfor NASP

Pathways & Interactionsfor NASP

Drugs & Compoundsfor NASP

Transcriptsfor NASP

Expression for NASP

Orthologsfor NASP

Paralogsfor NASP

SNPs/Variantsfor NASP

Disorders & Mutationsfor NASP

Medical Newsfor NASP

Publicationsfor NASP

Search for NASP

Genome Databases showing NASP

Other Databases showing NASP

Specialized Databases showing NASP

Licensable Technologiesfor NASP

Servicesfor NASP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NASP

Summaries
for NASP

Genomic Location
for NASP

Proteins
for NASP

Protein Domains/
Families
for NASP

Gene Function
for NASP

Pathways & Interactions
for NASP

Drugs & Compounds
for NASP

Transcripts
for NASP

Expression
for NASP

Orthologs
for NASP

Paralogs
for NASP

SNPs/Variants
for NASP

Disorders & Mutations
for NASP

Medical News
for NASP

Publications
for NASP

Licensable Technologies
for NASP

Services
for NASP