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Aliases for NASP Gene

Aliases for NASP Gene

  • Nuclear Autoantigenic Sperm Protein (Histone-Binding) 2 3
  • Nuclear Autoantigenic Sperm Protein 3
  • Histone H1-Binding Protein 3
  • FLB7527 3
  • PRO1999 3

External Ids for NASP Gene

Previous GeneCards Identifiers for NASP Gene

  • GC08M061216
  • GC01P045050
  • GC01P045479
  • GC01P045463
  • GC01P045718
  • GC01P045823
  • GC01P046049
  • GC01P044161

Summaries for NASP Gene

Entrez Gene Summary for NASP Gene

  • This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

GeneCards Summary for NASP Gene

NASP (Nuclear Autoantigenic Sperm Protein (Histone-Binding)) is a Protein Coding gene. GO annotations related to this gene include histone binding and Hsp90 protein binding.

UniProtKB/Swiss-Prot for NASP Gene

  • Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity).

Gene Wiki entry for NASP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NASP Gene

Genomics for NASP Gene

Regulatory Elements for NASP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NASP Gene

Start:
45,583,846 bp from pter
End:
45,618,906 bp from pter
Size:
35,061 bases
Orientation:
Plus strand

Genomic View for NASP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NASP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NASP Gene

Proteins for NASP Gene

  • Protein details for NASP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49321-NASP_HUMAN
    Recommended name:
    Nuclear autoantigenic sperm protein
    Protein Accession:
    P49321
    Secondary Accessions:
    • A8K6H2
    • B4DQP3
    • D3DQ07
    • F5H3J2
    • Q53GW5
    • Q5T622
    • Q5T625
    • Q96A69
    • Q9BTW2

    Protein attributes for NASP Gene

    Size:
    788 amino acids
    Molecular mass:
    85238 Da
    Quaternary structure:
    • Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity).

    Alternative splice isoforms for NASP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NASP Gene

Proteomics data for NASP Gene at MOPED

Post-translational modifications for NASP Gene

  • Ubiquitination at Lys52, Lys93, Lys535, Lys643, Lys657, Lys671, and Lys698
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NASP Gene

Domains for NASP Gene

Gene Families for NASP Gene

HGNC:
  • TTC :Tetratricopeptide (TTC) repeat domain containing

Graphical View of Domain Structure for InterPro Entry

P49321

UniProtKB/Swiss-Prot:

NASP_HUMAN :
  • P49321
Family:
  • Belongs to the NASP family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with NASP: view

Function for NASP Gene

Molecular function for NASP Gene

UniProtKB/Swiss-Prot Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity).

Gene Ontology (GO) - Molecular Function for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19498464
GO:0032403 protein complex binding IDA 25615412
GO:0042393 histone binding IEA --
GO:0051879 Hsp90 protein binding ISS --
genes like me logo Genes that share ontologies with NASP: view
genes like me logo Genes that share phenotypes with NASP: view

Animal Models for NASP Gene

MGI Knock Outs for NASP:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NASP Gene

Localization for NASP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NASP Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NASP Gene COMPARTMENTS Subcellular localization image for NASP gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0043234 protein complex IDA 14718166
genes like me logo Genes that share ontologies with NASP: view

Pathways for NASP Gene

SuperPathways for NASP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development ISS --
GO:0006260 DNA replication ISS --
GO:0006334 nucleosome assembly IDA 25615412
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
genes like me logo Genes that share ontologies with NASP: view

No data available for Pathways by source for NASP Gene

Transcripts for NASP Gene

Unigene Clusters for NASP Gene

Nuclear autoantigenic sperm protein (histone-binding):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NASP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NASP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: -
SP12: - - - - - - - - - -
SP13:

ExUns: 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for NASP Gene

GeneLoc Exon Structure for
NASP
ECgene alternative splicing isoforms for
NASP

Expression for NASP Gene

mRNA expression in normal human tissues for NASP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NASP Gene

SOURCE GeneReport for Unigene cluster for NASP Gene Hs.319334

mRNA Expression by UniProt/SwissProt for NASP Gene

P49321-NASP_HUMAN
Tissue specificity: Isoform 1 is testis- and sperm-specific
genes like me logo Genes that share expressions with NASP: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NASP Gene

Orthologs for NASP Gene

This gene was present in the common ancestor of animals.

Orthologs for NASP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NASP 35
  • 99.87 (n)
  • 99.87 (a)
NASP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NASP 35
  • 90.38 (n)
  • 87.63 (a)
NASP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NASP 35
  • 91.6 (n)
  • 88.8 (a)
NASP 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nasp 35
  • 86.91 (n)
  • 82.96 (a)
Nasp 16
Nasp 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NASP 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NASP 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nasp 35
  • 86.61 (n)
  • 82.12 (a)
chicken
(Gallus gallus)
Aves NASP 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NASP 36
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC397901 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nasp 35
  • 64.79 (n)
  • 57.36 (a)
Str.6461 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4774 35
zebrafish
(Danio rerio)
Actinopterygii nasp 36
  • 46 (a)
OneToOne
wufd20g12 35
fruit fly
(Drosophila melanogaster)
Insecta CG8223 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nasp-1 36
  • 28 (a)
OneToMany
nasp-2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8729 36
  • 37 (a)
OneToOne
Species with no ortholog for NASP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NASP Gene

ENSEMBL:
Gene Tree for NASP (if available)
TreeFam:
Gene Tree for NASP (if available)

Paralogs for NASP Gene

Pseudogenes.org Pseudogenes for NASP Gene

genes like me logo Genes that share paralogs with NASP: view

No data available for Paralogs for NASP Gene

Variants for NASP Gene

Sequence variations from dbSNP and Humsavar for NASP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs945178 -- 45,618,389(+) CTAAC(A/G)TGGAG utr-variant-3-prime
rs1053941 -- 45,618,711(+) TTTGA(G/T)CTCTG utr-variant-3-prime
rs1055414 -- 45,583,517(-) GATTG(G/T)CTACA upstream-variant-2KB
rs1058883 -- 45,609,940(+) ttcac(A/G)cctgt intron-variant
rs1136270 -- 45,610,043(+) aaaat(A/G)caaaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NASP Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
nsv871928 CNV Gain 21882294
esv273688 CNV Insertion 20981092

Relevant External Links for NASP Gene

HapMap Linkage Disequilibrium report
NASP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NASP Gene

Disorders for NASP Gene

No disorders were found for NASP Gene.

No data available for UniProtKB/Swiss-Prot for NASP Gene

Publications for NASP Gene

  1. Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. (PMID: 1426632) O'Rand M.G. … Widgren E.E. (Dev. Biol. 1992) 2 3 4 23
  2. Characterization of a sperm-specific nuclear autoantigenic protein. II. Expression and localization in the testis. (PMID: 2289011) Welch J.E. … O'Rand M.G. (Biol. Reprod. 1990) 3 23
  3. Ultrastructural localization of a nuclear autoantigenic sperm protein in spermatogenic cells and spermatozoa. (PMID: 8363049) Lee Y.H. … O'Rand M.G. (Anat. Rec. 1993) 3 23
  4. Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. (PMID: 10893414) Richardson R.T. … O'Rand M.G. (J. Biol. Chem. 2000) 3 23
  5. Analysis of the autoimmune epitopes on human testicular NASP using recombinant and synthetic peptides. (PMID: 10931132) Batova I.N. … O'Rand M.G. (Clin. Exp. Immunol. 2000) 3 23

Products for NASP Gene

Sources for NASP Gene

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