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Aliases for NASP Gene

Aliases for NASP Gene

  • Nuclear Autoantigenic Sperm Protein 2 3
  • Nuclear Autoantigenic Sperm Protein (Histone-Binding) 2 3 5
  • NASP Histone Chaperone 2 3
  • Histone H1-Binding Protein 3
  • FLB7527 3
  • PRO1999 3
  • HMDRA1 3

External Ids for NASP Gene

Previous GeneCards Identifiers for NASP Gene

  • GC08M061216
  • GC01P045050
  • GC01P045479
  • GC01P045463
  • GC01P045718
  • GC01P045823
  • GC01P046049
  • GC01P044161

Summaries for NASP Gene

Entrez Gene Summary for NASP Gene

  • This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa. [provided by RefSeq, Jul 2008]

GeneCards Summary for NASP Gene

NASP (Nuclear Autoantigenic Sperm Protein) is a Protein Coding gene. GO annotations related to this gene include protein complex binding and Hsp90 protein binding.

UniProtKB/Swiss-Prot for NASP Gene

  • Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity).

Gene Wiki entry for NASP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NASP Gene

Genomics for NASP Gene

Regulatory Elements for NASP Gene

Enhancers for NASP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NASP on UCSC Golden Path with GeneCards custom track

Promoters for NASP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NASP on UCSC Golden Path with GeneCards custom track

Genomic Location for NASP Gene

Chromosome:
1
Start:
45,583,846 bp from pter
End:
45,618,906 bp from pter
Size:
35,061 bases
Orientation:
Plus strand

Genomic View for NASP Gene

Genes around NASP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NASP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NASP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NASP Gene

Proteins for NASP Gene

  • Protein details for NASP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49321-NASP_HUMAN
    Recommended name:
    Nuclear autoantigenic sperm protein
    Protein Accession:
    P49321
    Secondary Accessions:
    • A8K6H2
    • B4DQP3
    • D3DQ07
    • F5H3J2
    • Q53GW5
    • Q5T622
    • Q5T625
    • Q96A69
    • Q9BTW2

    Protein attributes for NASP Gene

    Size:
    788 amino acids
    Molecular mass:
    85238 Da
    Quaternary structure:
    • Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity).

    Alternative splice isoforms for NASP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NASP Gene

Proteomics data for NASP Gene at MOPED

Post-translational modifications for NASP Gene

  • Ubiquitination at Lys 52, Lys 93, Lys 535, Lys 657, and Lys 671
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NASP Gene

Domains & Families for NASP Gene

Gene Families for NASP Gene

Graphical View of Domain Structure for InterPro Entry

P49321

UniProtKB/Swiss-Prot:

NASP_HUMAN :
  • Belongs to the NASP family.
  • Contains 3 TPR repeats.
Family:
  • Belongs to the NASP family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with NASP: view

Function for NASP Gene

Molecular function for NASP Gene

UniProtKB/Swiss-Prot Function:
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity).
genes like me logo Genes that share phenotypes with NASP: view

Animal Models for NASP Gene

MGI Knock Outs for NASP:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NASP Gene

Localization for NASP Gene

Subcellular locations from UniProtKB/Swiss-Prot for NASP Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NASP Gene COMPARTMENTS Subcellular localization image for NASP gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NASP Gene

Pathways & Interactions for NASP Gene

SuperPathways for NASP Gene

No Data Available

Gene Ontology (GO) - Biological Process for NASP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development ISS --
GO:0006260 DNA replication ISS --
GO:0006336 DNA replication-independent nucleosome assembly IDA 14718166
GO:0008584 male gonad development IEA --
GO:0043486 histone exchange ISS --
genes like me logo Genes that share ontologies with NASP: view

No data available for Pathways by source and SIGNOR curated interactions for NASP Gene

Drugs & Compounds for NASP Gene

No Compound Related Data Available

Transcripts for NASP Gene

Unigene Clusters for NASP Gene

Nuclear autoantigenic sperm protein (histone-binding):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NASP Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: -
SP7: - - -
SP8: - -
SP9: - - - -
SP10: - - - -
SP11: -
SP12: - - - - - - - - - -
SP13:

ExUns: 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
SP13:

Relevant External Links for NASP Gene

GeneLoc Exon Structure for
NASP
ECgene alternative splicing isoforms for
NASP

Expression for NASP Gene

mRNA expression in normal human tissues for NASP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NASP Gene

This gene is overexpressed in Fetal ovary (11.7) and Peripheral blood mononuclear cells (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NASP Gene



SOURCE GeneReport for Unigene cluster for NASP Gene Hs.319334

mRNA Expression by UniProt/SwissProt for NASP Gene

P49321-NASP_HUMAN
Tissue specificity: Isoform 1 is testis- and sperm-specific.
genes like me logo Genes that share expression patterns with NASP: view

Protein tissue co-expression partners for NASP Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for NASP Gene

Orthologs for NASP Gene

This gene was present in the common ancestor of animals.

Orthologs for NASP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NASP 35
  • 90.38 (n)
  • 87.63 (a)
NASP 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NASP 35
  • 91.6 (n)
  • 88.8 (a)
NASP 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nasp 35
  • 86.91 (n)
  • 82.96 (a)
Nasp 16
Nasp 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NASP 35
  • 99.87 (n)
  • 99.87 (a)
NASP 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nasp 35
  • 86.61 (n)
  • 82.12 (a)
oppossum
(Monodelphis domestica)
Mammalia NASP 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NASP 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves NASP 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NASP 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nasp 35
  • 64.79 (n)
  • 57.36 (a)
Str.6461 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397901 35
zebrafish
(Danio rerio)
Actinopterygii wufd20g12 35
nasp 36
  • 46 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4774 35
fruit fly
(Drosophila melanogaster)
Insecta CG8223 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nasp-1 36
  • 28 (a)
OneToMany
nasp-2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8729 36
  • 37 (a)
OneToOne
Species with no ortholog for NASP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NASP Gene

ENSEMBL:
Gene Tree for NASP (if available)
TreeFam:
Gene Tree for NASP (if available)

Paralogs for NASP Gene

Pseudogenes.org Pseudogenes for NASP Gene

genes like me logo Genes that share paralogs with NASP: view

No data available for Paralogs for NASP Gene

Variants for NASP Gene

Sequence variations from dbSNP and Humsavar for NASP Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34618000 - 45,615,308(-) TTAGT(A/C)CAGCT reference, missense
rs1136270 -- 45,610,043(+) aaaat(A/G)caaaa intron-variant
rs945178 -- 45,618,389(+) CTAAC(A/G)TGGAG utr-variant-3-prime
rs1053941 -- 45,618,711(+) TTTGA(G/T)CTCTG utr-variant-3-prime
rs1055414 -- 45,583,517(+) GATTG(A/C/G/T)CTACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NASP Gene

Variant ID Type Subtype PubMed ID
nsv829726 CNV Loss 17160897
nsv871928 CNV Gain 21882294
esv273688 CNV Insertion 20981092

Variation tolerance for NASP Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.16% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NASP Gene

Disorders for NASP Gene

Relevant External Links for NASP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NASP

No disorders were found for NASP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NASP Gene

Publications for NASP Gene

  1. Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. (PMID: 1426632) O'Rand M.G. … Widgren E.E. (Dev. Biol. 1992) 2 3 4 23 67
  2. Nucleosome formation activity of human somatic nuclear autoantigenic sperm protein (sNASP). (PMID: 20167597) Osakabe A. … Kurumizaka H. (J. Biol. Chem. 2010) 3 23
  3. Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. (PMID: 19439102) Alekseev O.M. … O'Rand M.G. (Reprod. Biol. Endocrinol. 2009) 3 23
  4. Expanded binding specificity of the human histone chaperone NASP. (PMID: 18782834) Wang H. … Parthun M.R. (Nucleic Acids Res. 2008) 3 23
  5. Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. (PMID: 16728391) Richardson R.T. … O'Rand M.G. (J. Biol. Chem. 2006) 3 23

Products for NASP Gene

Sources for NASP Gene

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