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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NASP Gene

protein-coding   GIFtS: 53
GCID: GC01P046049

Nuclear Autoantigenic Sperm Protein (Histone-Binding)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nuclear Autoantigenic Sperm Protein (Histone-Binding)1 2
FLB75272
PRO19992
Histone H1-Binding Protein2
Nuclear Autoantigenic Sperm Protein2

External Ids:    HGNC: 76441   Entrez Gene: 46782   Ensembl: ENSG000001327807   OMIM: 6031855   UniProtKB: P493213   

Export aliases for NASP gene to outside databases

Previous GC identifers: GC08M061216 GC01P045050 GC01P045479 GC01P045463 GC01P045718 GC01P045823 GC01P044161


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NASP Gene:
This gene encodes a H1 histone binding protein that is involved in transporting histones into the nucleus of
dividing cells. Multiple isoforms are encoded by transcript variants of this gene. The somatic form is expressed
in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is
expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the
cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature
spermatozoa. (provided by RefSeq, Jul 2008)

GeneCards Summary for NASP Gene: 
NASP (nuclear autoantigenic sperm protein (histone-binding)) is a protein-coding gene. Diseases associated with NASP include acalculous cholecystitis, and cholecystitis. GO annotations related to this gene include Hsp90 protein binding and histone binding.

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic
complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are
subsequently released from the complex and translocate to the nucleus where the histone is released for binding
to DNA (By similarity)

Gene Wiki entry for NASP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NASP gene promoter:
         Pax-5   Sp1   AP-4   C/EBPalpha   CHOP-10   AREB6   HFH-1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNASP promoter sequence
   Search SABiosciences Chromatin IP Primers for NASP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NASP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.1   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p34.1

NASP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NASP gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046049:  view genomic region     (about GC identifiers)

Start:
46,049,518 bp from pter      End:
46,084,578 bp from pter
Size:
35,061 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NASP_HUMAN, P49321 (See protein sequence)
Recommended Name: Nuclear autoantigenic sperm protein  
Size: 788 amino acids; 85238 Da
Subunit: Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This
interaction stimulates binding of NASP to HIST1H1T/H1T (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus
Secondary accessions: A8K6H2 B4DQP3 D3DQ07 F5H3J2 Q53GW5 Q5T622 Q5T625 Q96A69 Q9BTW2
Alternative splicing: 4 isoforms:  P49321-1   P49321-2   P49321-3   P49321-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NASP: NX_P49321

Explore proteomics data for NASP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49321

  • NASP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NASP Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001182122.1  NP_002473.2  NP_689511.2  

    ENSEMBL proteins: 
     ENSP00000400792   ENSP00000388010   ENSP00000435363   ENSP00000436790   ENSP00000435548  
     ENSP00000436778   ENSP00000436388   ENSP00000437241   ENSP00000436939   ENSP00000403157  
     ENSP00000432289   ENSP00000255120   ENSP00000436924   ENSP00000361122   ENSP00000255121  
     ENSP00000437116   ENSP00000434240   ENSP00000438871   ENSP00000384529  

    Human Recombinant Protein Products for NASP: 
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    Novus Biologicals NASP Protein
    Novus Biologicals NASP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NASP 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IEA--

    NASP for ontologies           About GeneDecksing



    NASP Antibody Products: 
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    Cloud-Clone Corp. CLIAs for NASP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TTC: Tetratricopeptide (TTC) repeat domain containing

    5 InterPro protein domains:
     IPR011990 TPR-like_helical
     IPR019544 Tetratricopeptide_SHNi-TPR_dom
     IPR001440 TPR-1
     IPR013026 TPR-contain_dom
     IPR019734 TPR_repeat

    Graphical View of Domain Structure for InterPro Entry P49321

    ProtoNet protein and cluster: P49321

    UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
    Similarity: Belongs to the NASP family
    Similarity: Contains 3 TPR repeats


    NASP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NASP_HUMAN, P49321
    Function: Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic
    complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are
    subsequently released from the complex and translocate to the nucleus where the histone is released for binding
    to DNA (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042393histone binding IEA--
    GO:0051879Hsp90 protein binding ISS--
         
    NASP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NASP:
     Increased cell death in breast 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nasp):
     embryogenesis  growth/size  mortality/aging 

    NASP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nasptm1Mgor for NASP

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NASP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NASP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NASP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NASP 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NASP
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NASP (see all 18):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-3616-5p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-3653 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidNASP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NASP
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): NASP (NM_152298)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NASP
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                         Customized lentivirus expression plasmids for stable overexpression of NASP 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NASP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NASP

    5/68 Interacting proteins for NASP (P493212, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4BP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4CP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4DP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4EP628052, 3MINT-7220359 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development ISS--
    GO:0006260DNA replication ISS--
    GO:0007049cell cycle ISS--
    GO:0008283cell proliferation ISS--
    GO:0015031protein transport IEA--

    NASP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NASP

    Search CenterWatch for drugs/clinical trials and news about NASP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NASP gene (4 alternative transcripts): 
    NM_001195193.1  NM_002482.3  NM_152298.3  NM_172164.1  

    Unigene Cluster for NASP:

    Nuclear autoantigenic sperm protein (histone-binding)
    Hs.319334  [show with all ESTs]
    Unigene Representative Sequence: AY700118
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000437901 ENST00000437362 ENST00000464190 ENST00000528084 ENST00000527359
    ENST00000530840 ENST00000531532 ENST00000529333 ENST00000527470 ENST00000525515
    ENST00000453748(uc001cok.2 uc010olq.2) ENST00000528238 ENST00000534101
    ENST00000350030(uc001coi.2 uc001coj.2 uc010olr.2) ENST00000470768
    ENST00000372052 ENST00000351223 ENST00000530073
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NASP
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NASP (see all 18):
    hsa-miR-323-3p hsa-miR-300 hsa-miR-3616-5p hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-3653 hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidNASP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NASP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NASP
    Clone
    Products:
         
    OriGene clones in human, mouse for NASP (see all 17)
    OriGene ORF clones in mouse, rat for NASP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NASP (NM_152298)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NASP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NASP
    Sirion Biotech Customized lentivirus for stable overexpression of NASP 
                         Customized lentivirus expression plasmids for stable overexpression of NASP 
    Primer
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    OriGene qPCR primer pairs and template standards for NASP
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NASP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NASP

    Additional mRNA sequence: 

    AF035191.1 AK056161.1 AK131249.1 AK222778.1 AK222816.1 AK291637.1 AK298893.1 AK299584.1 
    AK308001.1 AL512718.1 AY700118.1 BC003113.1 BC009933.2 BC010105.2 BC011580.1 BC053608.1 
    BT006757.1 M97856.1 

    24/45 DOTS entries (see all 45):

    DT.92460539  DT.92460525  DT.100032703  DT.87016487  DT.92460535  DT.100665291  DT.91887358  DT.100856779 
    DT.100038627  DT.92460531  DT.100863204  DT.102838067  DT.121343899  DT.121343702  DT.100665287  DT.97860848 
    DT.121343839  DT.40219355  DT.100670180  DT.121343898  DT.92460537  DT.102838070  DT.75110901  DT.95378235 

    24/683 AceView cDNA sequences (see all 683):

    AI918171 BQ441755 BQ892029 CK300084 CR601591 BX425926 BE671829 BE671747 
    BM457493 BM478535 BQ649212 BU183796 BE743475 CB133707 BM718227 CR621701 
    CD366592 BF883423 BM854473 AU132982 NM_172164 BP873580 BU150526 BQ008419 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NASP (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^
    SP1:                          -     -                             -                       -           -                 -                                   -   
    SP2:                          -     -                             -     -     -     -     -           -                 -                                   -   
    SP3:                          -                                   -                       -           -                 -                                       
    SP4:                          -                                   -     -     -     -     -           -                                                         
    SP5:                          -     -     -     -     -     -     -     -     -     -     -           -                 -                                       

    ExUns: 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for NASP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NASP expression in normal human tissues (normalized intensities)      NASP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTAAGAGGGG
    NASP Expression
    About this image


    NASP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             superior temporal gyrus   
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Lymph (Hematopoietic System)

    See NASP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NASP

    SOURCE GeneReport for Unigene cluster: Hs.319334

    UniProtKB/Swiss-Prot: NASP_HUMAN, P49321
    Tissue specificity: Isoform 1 is testis- and sperm-specific

        SABiosciences Custom PCR Arrays for NASP
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NASP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NASP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NASP gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nasp1 , 5 nuclear autoantigenic sperm protein (histone-binding)1, 5 86.78(n)1
    82.83(a)1
      4 (53.24 cM)5
    509271  NM_016777.31  NP_058057.31 
     1166010525 
    chicken
    (Gallus gallus)
    Aves NASP1 nuclear autoantigenic sperm protein (histone-binding) 62.88(n)
    55.98(a)
      424600  XM_001235059.2  XP_001235060.2 
    lizard
    (Anolis carolinensis)
    Reptilia NASP6
    Uncharacterized protein
    47(a)
    1 ↔ 1
    4(110130810-110148325)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3979012 Xenopus laevis mRNA for histone-binding protein N1/N2 75.25(n)    X04712.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd20g122 wufd20g12 76.13(n)   327300  BC045857.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82236
    --
    24(a)
    1 ↔ 1
    3R(4573528-4581638)
    worm
    (Caenorhabditis elegans)
    Secernentea nasp-11 Protein NASP-1 47.89(n)
    30.22(a)
      174697  NM_063979.4  NP_496380.1 
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0D04136g1 hypothetical protein 44.99(n)
    30.74(a)
      2893462  XM_453248.1  XP_453248.1 


    ENSEMBL Gene Tree for NASP (if available)
    TreeFam Gene Tree for NASP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NASP gene
    1 SIMAP similar gene for NASP using alignment to 16 protein entries:     NASP_HUMAN (see all proteins):
    ADAT1

    NASP for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NASP
    PGOHUM00000258344


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/881 SNPs in NASP are shown (see all 881)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs674364171,2
    C--44163852(+) AGAAA-/TAAA  
            
    CCTCA
    3 -- int11Minor allele frequency- TAAA:0.50NA 2
    rs669876041,2
    C--44165971(+) TCAAGTGTT/-  
            
    TGTTT
    3 -- int11Minor allele frequency- -:0.50CSA 2
    rs561813551,2
    C--44165994(+) TTTGT-/TTGT  
            
    GAGTG
    3 -- int11Minor allele frequency- TTGT:0.00NA 2
    rs611343951,2
    C--46048758(+) GGGGGG/-TCTCA 3 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2011538201,2
    --46050003(+) TCGCT-/GTTC  
            
    GGGAA
    3 -- int10--------
    rs572575301,2
    C--46050005(+) GCTGT-/TCGG  
            
    GAAGG
    3 -- int12Minor allele frequency- TCGG:0.00NA CSA 4
    rs725186071,2
    C--46051912(+) GTGCC-/GTGTGTGT
    GTGTGTGTGT
    GTGTG
    3 -- int10--------
    rs57738851,2
    C--46051956(+) tgtgt-/Ggtgtg 3 -- int10--------
    rs752935551,2
    --46054653(+) TTTGTG/TTGTGA 3 -- int10--------
    rs801397721,2
    C--46054654(+) TTGTTA/TGTGAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for NASP (46049518 - 46084578 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NASP:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv273688CNV Insertion20981092
    nsv829726CNV Loss17160897
    nsv871928CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603185    OMIM disorders: --

    10 diseases for NASP:    About MalaCards
    acalculous cholecystitis    cholecystitis    seminoma    epididymitis
    hypoxia    ovarian cancer    prostate cancer    prostatitis
    hepatitis    neuronitis


    NASP for disorders           About GeneDecksing


    Export disorders for NASP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NASP gene, integrated from 9 sources (see all 78):
    (articles sorted by number of sources associating them with NASP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein. (PubMed id 1426632)1, 2, 3, 9 O'Rand M.G.... Widgren E.E. (1992)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Histone-binding domains in a human nuclear autoantigenic sperm protein. (PubMed id 8724350)1, 2 Batova I. and O'Rand M.G. (1996)
    8. Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. (PubMed id 19439102)1, 9 Alekseev O.M....O'Rand M.G. (2009)
    9. Characterization of the histone H1-binding protein, NASP, as a cell cycle-regulated somatic protein. (PubMed id 10893414)1, 9 Richardson R.T....O'Rand M.G. (2000)
    10. Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation. (PubMed id 16728391)1, 9 Richardson R.T....O'Rand M.G. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4678 HGNC: 7644 AceView: NASP Ensembl:ENSG00000132780 euGenes: HUgn4678
    ECgene: NASP H-InvDB: NASP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NASP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NASP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NASP gene:
    Search GeneIP for patents involving NASP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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