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NARS2 Gene

protein-coding   GIFtS: 62
GCID: GC11M078147

Asparaginyl-TRNA Synthetase 2, Mitochondrial (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Asparaginyl-TRNA Synthetase 2, Mitochondrial (Putative)1 2     Asparagine--TRNA Ligase2
EC 6.1.1.223 8     Probable Asparagine--TRNA Ligase, Mitochondrial2
Asparagine TRNA Ligase 21     Probable Asparaginyl-TRNA Synthetase, Mitochondrial2
Mitochondrial (Putative)1     AsnRS3
SLM52     Asparaginyl-TRNA Synthetase3
asnRS2     EC 6.1.18
Asparagine TRNA Ligase 2, Mitochondrial (Putative)2     

External Ids:    HGNC: 262741   Entrez Gene: 797312   Ensembl: ENSG000001375137   OMIM: 6128035   UniProtKB: Q96I593   
ORGUL members:         

Export aliases for NARS2 gene to outside databases

Previous GC identifers: GC11M077825 GC11M074444


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NARS2 Gene:
NARS2 (asparaginyl-tRNA synthetase 2, mitochondrial (putative)) is a protein-coding gene. Diseases associated with NARS2 include inclusion conjunctivitis, and conjunctivitis. GO annotations related to this gene include asparagine-tRNA ligase activity and nucleic acid binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NARS2 gene promoter:
         HNF-4alpha2   AP-4   HNF-4alpha1   Evi-1   NF-AT   MZF-1   NF-AT4   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNARS2 promoter sequence
   Search Chromatin IP Primers for NARS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NARS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

NARS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NARS2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M078147:  view genomic region     (about GC identifiers)

Start:
78,147,007 bp from pter      End:
78,285,919 bp from pter
Size:
138,913 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SYNM_HUMAN, Q96I59 (See protein sequence)
Recommended Name: Probable asparagine--tRNA ligase, mitochondrial precursor  
Size: 477 amino acids; 54090 Da

Explore the universe of human proteins at neXtProt for NARS2: NX_Q96I59

Explore proteomics data for NARS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NARS2 (Q96I59) (see all 6)
     PIITSND  WYLDLRR  LTVSGQL  PTFRAENS 


    See NARS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230180.1  NP_078954.4  

    ENSEMBL proteins: 
     ENSP00000281038   ENSP00000435298   ENSP00000432635   ENSP00000436114   ENSP00000432240  
     ENSP00000433478  
    Reactome Protein details: Q96I59

    NARS2 Human Recombinant Protein Products:

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    Novus Biologicals NARS2 Lysates
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    Cloud-Clone Corp. CLIAs for NARS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    Selected InterPro protein domains (see all 7):
     IPR004522 Asn-tRNA-ligase
     IPR006195 aa-tRNA-synth_II
     IPR004364 aa-tRNA-synt_II
     IPR012340 NA-bd_OB-fold
     IPR004365 NA-bd_OB_tRNA

    Graphical View of Domain Structure for InterPro Entry Q96I59

    ProtoNet protein and cluster: Q96I59

    3 Blocks protein domains:
    IPB002312 Aspartyl-tRNA synthetase signature
    IPB004364 tRNA synthetase
    IPB004365 OB-fold nucleic acid binding domain


    UniProtKB/Swiss-Prot: SYNM_HUMAN, Q96I59
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    NARS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNM_HUMAN, Q96I59
    Catalytic activity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

         Enzyme Numbers (IUBMB): EC 6.1.1.221 2 EC 6.1.12

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003676nucleic acid binding IEA--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004816asparagine-tRNA ligase activity ISS--
    GO:0005524ATP binding IEA--
         
    NARS2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NARS2:
     Increased S DNA content  Small cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NARS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NARS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NARS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NARS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NARS2:
    hsa-let-7b-5p (MIRT032305), hsa-mir-16-5p (MIRT031482), hsa-mir-26b-5p (MIRT029094)

    Block miRNA regulation of human, mouse, rat NARS2 using miScript Target Protectors
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NARS2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NARS2 (NM_024678)
    Sino Biological Human cDNA Clone for NARS2
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARS2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYNM_HUMAN, Q96I59: Mitochondrion matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ISS--
    GO:0005759mitochondrial matrix IEA--

    NARS2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NARS2 About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Mitochondrial tRNA aminoacylation0.50
    Aminoacyl-tRNA biosynthesis0.52
    2Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NARS2
        Mitochondrial tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for NARS2):
        Aminoacyl-tRNA biosynthesis


    NARS2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NARS2
    Interactions:

        Search GeneGlobe Interaction Network for NARS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NARS2 (Q96I593 ENSP000002810384) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006421asparaginyl-tRNA aminoacylation ISS--
    GO:0010467gene expression TAS--

    NARS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NARS2 (SYNM)

    5 HMDB Compounds for NARS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for NARS2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--16753178 12874385



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NARS2 gene (2 alternative transcripts): 
    NM_001243251.1  NM_024678.5  

    Unigene Cluster for NARS2:

    Asparaginyl-tRNA synthetase 2, mitochondrial (putative)
    Hs.503389  [show with all ESTs]
    Unigene Representative Sequence: NM_024678
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281038(uc010rsq.2 uc001ozi.3) ENST00000529771 ENST00000528850
    ENST00000525345 ENST00000529880 ENST00000529571 ENST00000526709
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NARS2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NARS2
    SwitchGear 3'UTR luciferase reporter plasmidNARS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NARS2
    Predesigned siRNA for gene silencing in human, mouse, rat NARS2
    Clone
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    GenScript: all cDNA clones in your preferred vector: NARS2 (NM_024678)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NARS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARS2
    Primer
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    OriGene qPCR primer pairs and template standards for NARS2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NARS2
      QuantiTect SYBR Green Assays in human, mouse, rat NARS2
      QuantiFast Probe-based Assays in human, mouse, rat NARS2

    Additional mRNA sequence: 

    AK027094.1 AK056980.1 AK225444.1 AK315425.1 BC007800.2 

    8 DOTS entries:

    DT.411699  DT.95077558  DT.100766180  DT.100804478  DT.92425669  DT.95077555  DT.91665164  DT.120746611 

    Selected AceView cDNA sequences (see all 143):

    CR600469 AI025839 AW470878 CB157768 AI347816 CD520140 AW968557 AI436094 
    AI859305 CB151891 AI983291 BP353228 CA419766 AI654128 BI823322 BQ011575 
    BC007800 BQ372908 CA313358 CD632206 BU176731 AI183590 NM_024678 BI251987 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NARS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGATTTT
    NARS2 Expression
    About this image

    NARS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NARS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.503389
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NARS2 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nars21 , 5 asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)1, 5 85.19(n)1
    84.49(a)1
      7 (53.13 cM)5
    2441411  NM_153591.41  NP_705819.31 
     969515055 
    chicken
    (Gallus gallus)
    Aves NARS21 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 72.76(n)
    76.05(a)
      419026  XM_417219.4  XP_417219.2 
    lizard
    (Anolis carolinensis)
    Reptilia NARS26
    asparaginyl-tRNA synthetase 2, mitochondrial (puta...
    71(a)
    1 ↔ 1
    GL343337.1(161288-242865)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.311512 Xenopus laevis transcribed sequence with weak similarity more 74.81(n)    48012162 
    zebrafish
    (Danio rerio)
    Actinopterygii nars21 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 65.71(n)
    68.81(a)
      561673  NM_001077155.1  NP_001070623.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG67961 CG6796 49.3(n)
    41.59(a)
      36909  NM_137332.3  NP_611176.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nars-26
    Protein NARS-2 (nars-2) mRNA, complete cds
    37(a)
    1 ↔ 1
    III(11488355-11500735) WBGene00013447
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLM5(YCR024C)4
    SLM51
    Mitochondrial asparaginyl-tRNA synthetase4
    SLM51
    48.51(n)1
    40.61(a)1
      3(162222-160744)4
    8503881, 4  NP_009953.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NS11 NS1 54.88(n)
    50.7(a)
      827443  NM_117835.4  NP_193462.1 
    rice
    (Oryza sativa)
    Liliopsida NM_193854.12   -- 74.21(n)    NM_193854.1 


    ENSEMBL Gene Tree for NARS2 (if available)
    TreeFam Gene Tree for NARS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NARS2 gene
    3 SIMAP similar genes for NARS2 using alignment to 5 protein entries:     SYNM_HUMAN (see all proteins):
    NARS    DARS    DKFZp781B11202

    NARS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NARS2 (see all 3237)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10222711,2
    C,H--78146513(-) GTTTAG/AAACCT 2 -- ds50014Minor allele frequency- A:0.00NS EA 418
    rs10222701,2
    C,H--78146534(-) GAAAAG/AAGCAT 2 -- ds50014Minor allele frequency- A:0.00NS EA 412
    rs10222691,2
    H--78146537(-) AGTGAG/AAAAAG 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs610873701,2
    C,F--78146723(+) ACCACG/ACCTGG 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1444395481,2
    C--78147021(+) CTATT-/AAAAAA 2 -- ut310--------
    rs15678891,2
    C,F,A,H--78147055(-) TTTGAT/CGTTTA 2 -- ut3195Minor allele frequency- C:0.32NS MN EA NA PA EU CA WA 5010
    rs1462112041,2
    --78147075(+) ATTAT-/AACAACAG 2 -- cds10--------
    rs79349481,2
    C,F,H--78147374(+) AGTGAT/CTTAAT 2 -- ut31 ese395Minor allele frequency- C:0.04NS EA PA EU CA WA NA 5356
    rs1422988611,2
    C--78147393(+) ACAACA/GTAAAA 2 -- ut310--------
    rs1460912481,2
    C--78147440(+) CTTTGA/GGACTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NARS2 (78147007 - 78285919 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NARS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662654CNV Deletion23128226
    nsv516040CNV Loss19592680
    dgv1227n71CNV Gain21882294
    dgv1226n71CNV Gain21882294
    nsv468642CNV Gain19166990

    Human Gene Mutation Database (HGMD): NARS2
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612803    OMIM disorders: --

    4 diseases for NARS2:    
    About MalaCards
    inclusion conjunctivitis    conjunctivitis    pneumonia    malaria

    1 disease from the University of Copenhagen DISEASES database for NARS2:
    Inclusion conjunctivitis

    NARS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NARS2
    Human Genome Epidemiology (HuGE) Navigator: NARS2 (2 documents)

    Export disorders for NARS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NARS2 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with NARS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 2, 3 Bonnefond L....Sissler M. (Biochemistry 2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    9. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79731 HGNC: 26274 AceView: FLJ23441 Ensembl:ENSG00000137513 euGenes: HUgn79731
    ECgene: NARS2 Kegg: 79731 H-InvDB: NARS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NARS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NARS2 gene:
    Search GeneIP for patents involving NARS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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