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Aliases & Descriptions for NARS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ASNRS 2, 5 | | ASNS 3 | | AsnRS 3 | | EC 6.1.1.22 3 | | NARS1 1, 2 |
| | | Descriptions |
|---|
| Asparagine--tRNA ligase 3 | | asparagine tRNA ligase 1, cytoplasmic 2 | | asparaginyl-tRNA synthetase 2 |
|
| | Search outside databases for aliases for NARS genePrevious GC identifers: GC18M055658 GC18M055242 GC18M055052 GC18M053416 |
Summaries for NARS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NARS: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq] Gene Wiki entry for NARS |
Genomic Location for NARS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NARS gene 
Entrez Gene cytogenetic band: 18q21.2-q21.3 Ensembl cytogenetic band: 18q21.31 HGNC cytogenetic band: 18q21.31NARS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M053418:
(about GC identifiers)
Start:
|
53,418,889 bp from pter |
End:
|
53,440,175 bp from pter |
Size:
|
21,287 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000018.8 NT_025028.13
| Proteins for NARS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYNC_HUMAN, O43776 (See
protein sequence)Recommended Name: Asparaginyl-tRNA synthetase, cytoplasmic Size: 548 amino acids; 62943 Da
Subcellular location: Cytoplasm
Secondary accessions: Q53GU6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004530.1
ENSEMBL proteins: ENSP00000256854
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NARS: Assays for NARS: | Protein
Domains/ Families for NARS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43776
ProtoNet protein and cluster: O43776 3 Blocks protein families: IPB002312 Aspartyl-tRNA synthetase signature IPB004364 tRNA synthetase IPB004365 OB-fold nucleic acid binding domain
UniProtKB/Swiss-Prot: SYNC_HUMAN, O43776Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family | Gene Function for NARS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004539
Applied Biosystems Silencer® siRNAs for NARS
Sigma-Aldrich siRNA for NARS  Sigma-Aldrich shRNA for NARS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004539                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004539                                  untagged cDNA clone in CMV expression vector: NM_004539 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004539
UniProtKB/Swiss-Prot: SYNC_HUMAN, O43776Catalytic activity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)Enzyme Number (IUBMB): EC 6.1.1.22 Genatlas biochemistry entry for NARS:asparaginyl-tRNA synthetase5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for NARS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for NARS (Your Favorite Gene powered by Ingenuity) 
5/10 Interacting proteins for NARS (O437761, 2 ENSP000002568543) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006421 | asparaginyl-tRNA aminoacylation |
IEA | -- | | GO:0006422 | aspartyl-tRNA aminoacylation |
IEA | -- | About this table
|
Drugs & Compounds for NARS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NARS 4 Novoseek chemical compound relationships for NARS gene
About this table
|
Transcripts for NARS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004539
Sigma-Aldrich siRNA for NARS  Sigma-Aldrich shRNA for NARS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004539 REFSEQ mRNAs for NARS gene: NM_004539.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004539               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004539                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004539                                  untagged cDNA clone in CMV expression vector: NM_004539  Additional cDNA sequence: AJ000334.1 AK129897.1 AK222835.1 AK293985.1 AK294364.1 AK294763.1 AK297777.1 BC001687.1 CR609633.1 D84273.1 U79254.1 24/28 DOTS entries (see all 28
): DT.419312 DT.97855359 DT.102832966 DT.121084213 DT.100869391 DT.100673910 DT.100848843 DT.91722905 DT.100673905 DT.95083245 DT.422320 DT.91769794 DT.92023625 DT.100673909 DT.100673906 DT.92404386 DT.121084198 DT.121084209 DT.91769789 DT.95162534 DT.95162574 DT.121084181 DT.121084196 DT.121084218 24/637 AceView cDNA sequences (see all 637
):BX956359 BX952354 AW117736 BU527745 CR609633 CK299384 BX343744 BG260345 BP365666 CD654817 BU665242 BQ051329 AA305871 AW150744 AA448652 BU624871 N93735 BQ447627 BM782185 AW204862 AW027895 BQ878169 BM839702 BQ213524
highest scoring ESTs for NARS:D84273 AA219340 AA307724 AA314303 AA361411 AA545788 AJ000334 AK129897 AL602338 AL602587 Unigene Cluster for NARS: Asparaginyl-tRNA synthetase Hs.465224 [show with all ESTs]Unigene Representative Sequence: NM_004539
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NARS
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NARS
1 Ensembl transcript including schematic representation: ENST00000256854
|
Expression for NARS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NARS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NARS
1 / 2 / 3 3 probe-sets matching NARS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATTCTCAAT
SOURCE GeneReport for Unigene cluster: Hs.465224
Expression variation in blood from EXPOLDB for NARS |
Orthologs for NARS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NARS gene from 5/17 species (see all 17
)
About this table Species with no ortholog for NARS
ENSEMBL Gene Tree for NARS | Paralogs for NARS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NARS gene
- NARS22 DARS2
|
SNPs/Variants for NARS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NARS (up to first 250kb)
|
Disorders & Mutations for NARS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 108410
2 Novoseek disease relationships for NARS gene
About this table
|
Medical News for NARS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NARS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/31 PubMed articles for NARS gene (see all 31
):- Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PubMed id 9421509)1, 2, 3, 4 Beaulande M....Hartlein M. (1998)
- Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PubMed id 9801298)1, 3, 4 Shiba K.... Noda T. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PubMed id 6836455)2, 3 Cirullo R.E....Wasmuth J.J. (1983)
- Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross- validation of MS/MS and MS/MS/MS Spectra. (PubMed id 17924679)4 Yu L.-R.... Veenstra T.D. (2007)
- A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)3 Lim J....Zoghbi H.Y. (2006)
- A protein interaction framework for human mRNA degradation. (PubMed id 15231747)3 Lehner B. and Sanderson C.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)3 Yu W....Gibbs R.A. (1997)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)3 Suzuki Y.... Sugano S. (1997)
|
Search for NARS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NARS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NARS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NARS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NARS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NARS:

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| | Recombinant Proteins (NARS) | | Antibodies (NARS) |
| | | Search Tocris compounds for NARS |
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