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Aliases for NARS Gene

Aliases for NARS Gene

  • Asparaginyl-TRNA Synthetase 2 3 4 5
  • Asparagine TRNA Ligase 1, Cytoplasmic 2 3
  • EC 6.1.1.22 4 61
  • ASNRS 3 4
  • Asparaginyl-TRNA Synthetase, Cytoplasmic 3
  • Asparagine--TRNA Ligase, Cytoplasmic 3
  • NARS1 3

External Ids for NARS Gene

Previous GeneCards Identifiers for NARS Gene

  • GC18M055658
  • GC18M055242
  • GC18M055052
  • GC18M053416
  • GC18M053418
  • GC18M051978
  • GC18M055267

Summaries for NARS Gene

Entrez Gene Summary for NARS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARS Gene

NARS (Asparaginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with NARS include Myositis. Among its related pathways are tRNA Aminoacylation and Gene Expression. GO annotations related to this gene include nucleic acid binding and aminoacyl-tRNA ligase activity.

Gene Wiki entry for NARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARS Gene

Genomics for NARS Gene

Regulatory Elements for NARS Gene

Enhancers for NARS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F057649 1.1 Ensembl ENCODE 15.9 -27.9 -27852 1.3 GTF2F1 PKNOX1 JUN ASH2L FEZF1 BMI1 RAD21 BRCA1 RFX5 ZNF316 NARS RNU6-742P HMGN1P30 ENSG00000267787 TRG-TCC5-1
GH18F057786 1 Ensembl ENCODE 15.7 -166.3 -166333 4.6 KLF1 ARNT CREB3L1 JUN SIN3A ZMYM3 FEZF1 RAD21 FOS MAFK NARS RNU6-742P ATP8B1 MRPS17P7
GH18F057664 1.2 Ensembl ENCODE 11.4 -44.3 -44288 4.2 HDAC1 PKNOX1 ATF1 ARNT TBL1XR1 GATA2 SCRT2 ETV6 CREM NCOA1 NARS TRG-TCC5-1 ENSG00000267787
GH18F057619 1.1 ENCODE 12 +0.9 854 3.3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ATP8B1 NARS GC18M057596
GH18F057812 1.2 FANTOM5 Ensembl ENCODE 10 -191.3 -191336 1.9 JUN BHLHE40 CEBPB USF2 SIN3A EP300 RFX5 JUND FOS RCOR1 ATP8B1 RNU6-742P NARS GC18M057807
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NARS on UCSC Golden Path with GeneCards custom track

Promoters for NARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001515565 413 2401 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS

Genomic Location for NARS Gene

Chromosome:
18
Start:
57,600,656 bp from pter
End:
57,622,213 bp from pter
Size:
21,558 bases
Orientation:
Minus strand

Genomic View for NARS Gene

Genes around NARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARS Gene

Proteins for NARS Gene

  • Protein details for NARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43776-SYNC_HUMAN
    Recommended name:
    Asparagine--tRNA ligase, cytoplasmic
    Protein Accession:
    O43776
    Secondary Accessions:
    • B4DG16
    • Q53GU6

    Protein attributes for NARS Gene

    Size:
    548 amino acids
    Molecular mass:
    62943 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NARS Gene

    Alternative splice isoforms for NARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARS Gene

Selected DME Specific Peptides for NARS Gene

O43776:
  • LNLTPKGKQAPGGHELSCDFWEL
  • LMFLVLRDG
  • VEGGATLFK
  • TRCFRDHFFDRGY
  • VQTQVEGG
  • LTQSSQLYLETC
  • LTESVDVLMPNVGEIVGGSMR
  • GLGLERFLTWI

Post-translational modifications for NARS Gene

  • Ubiquitination at Lys 60, Lys 104, Lys 445, Lys 490, and Lys 507
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for NARS Gene

Gene Families for NARS Gene

Graphical View of Domain Structure for InterPro Entry

O43776

UniProtKB/Swiss-Prot:

SYNC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with NARS: view

Function for NARS Gene

Molecular function for NARS Gene

GENATLAS Biochemistry:
asparaginyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

Enzyme Numbers (IUBMB) for NARS Gene

Gene Ontology (GO) - Molecular Function for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004816 asparagine-tRNA ligase activity IEA,TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with NARS: view
genes like me logo Genes that share phenotypes with NARS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NARS

miRNA for NARS Gene

miRTarBase miRNAs that target NARS

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARS Gene

Localization for NARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NARS gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NARS: view

Pathways & Interactions for NARS Gene

genes like me logo Genes that share pathways with NARS: view

Pathways by source for NARS Gene

1 KEGG pathway for NARS Gene

Gene Ontology (GO) - Biological Process for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation IEA,TAS --
GO:0006421 asparaginyl-tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with NARS: view

No data available for SIGNOR curated interactions for NARS Gene

Drugs & Compounds for NARS Gene

(4) Drugs for NARS Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(5) Additional Compounds for NARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with NARS: view

Transcripts for NARS Gene

Unigene Clusters for NARS Gene

Asparaginyl-tRNA synthetase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NARS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for NARS Gene

GeneLoc Exon Structure for
NARS
ECgene alternative splicing isoforms for
NARS

Expression for NARS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NARS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NARS Gene



Protein tissue co-expression partners for NARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NARS Gene:

NARS

SOURCE GeneReport for Unigene cluster for NARS Gene:

Hs.465224
genes like me logo Genes that share expression patterns with NARS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NARS Gene

Orthologs for NARS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARS 34 35
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 92 (a)
OneToMany
NARS 34
  • 87.65 (n)
-- 35
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NARS 34 35
  • 90.94 (n)
oppossum
(Monodelphis domestica)
Mammalia NARS 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nars 34
  • 86.72 (n)
mouse
(Mus musculus)
Mammalia Nars 34 16 35
  • 86.68 (n)
chicken
(Gallus gallus)
Aves NARS 34 35
  • 79.87 (n)
lizard
(Anolis carolinensis)
Reptilia NARS 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nars 34
  • 74.88 (n)
zebrafish
(Danio rerio)
Actinopterygii nars 34 35
  • 72.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06451 36
  • 73 (a)
Aats-asn 34 35
  • 62.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002969 34
  • 63.08 (n)
worm
(Caenorhabditis elegans)
Secernentea nars-1 34 35
  • 58.15 (n)
nrs-1 36
  • 58 (a)
Y66D12A.23 36
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED81 34 35 37
  • 56.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08426g 34
  • 56.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL020W 34
  • 53.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 66 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06457 34
  • 54.31 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nrs1 34
  • 53.35 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4788 34
Species where no ortholog for NARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARS Gene

ENSEMBL:
Gene Tree for NARS (if available)
TreeFam:
Gene Tree for NARS (if available)

Paralogs for NARS Gene

(2) SIMAP similar genes for NARS Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for NARS Gene

genes like me logo Genes that share paralogs with NARS: view

No data available for Paralogs for NARS Gene

Variants for NARS Gene

Sequence variations from dbSNP and Humsavar for NARS Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1059593 -- 57,601,413(-) AAATA(C/T)CTGGC utr-variant-3-prime
rs1059645 -- 57,600,815(-) CCCCC(A/C)CCATG utr-variant-3-prime
rs1059648 -- 57,600,800(-) TAGAT(C/T)TAATC utr-variant-3-prime
rs1059668 -- 57,600,727(-) TCTCC(A/C)CCAAA utr-variant-3-prime
rs111246118 -- 57,619,179(+) AGCCT(C/T)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NARS Gene

Variant ID Type Subtype PubMed ID
dgv203e215 CNV deletion 23714750
esv2751777 CNV gain 17911159
esv3328362 CNV duplication 20981092
nsv1134720 CNV deletion 24896259
nsv458086 CNV gain 19166990
nsv577032 CNV gain 21841781
nsv833663 CNV gain 17160897

Variation tolerance for NARS Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NARS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARS Gene

Disorders for NARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for NARS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myositis
  • inflammatory disorder of muscle
- elite association - COSMIC cancer census association via MalaCards
Search NARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NARS

Genetic Association Database (GAD)
NARS
Human Genome Epidemiology (HuGE) Navigator
NARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NARS
genes like me logo Genes that share disorders with NARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NARS Gene

Publications for NARS Gene

  1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PMID: 9421509) Beaulande M. … Haertlein M. (Nucleic Acids Res. 1998) 2 3 4 22 64
  2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PMID: 9801298) Shiba K. … Noda T. (Nucleic Acids Res. 1998) 3 4 22 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PMID: 6836455) Cirullo R.E. … Wasmuth J.J. (Somatic Cell Genet. 1983) 2 3 64

Products for NARS Gene

Sources for NARS Gene

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