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Aliases for NARS Gene

Aliases for NARS Gene

  • Asparaginyl-TRNA Synthetase 4 2 3
  • AsnRS 3 4 6
  • EC 6.1.1.22 4 63
  • Asparaginyl-TRNA Synthetase, Cytoplasmic 3
  • Asparagine TRNA Ligase 1, Cytoplasmic 3
  • Asparagine--TRNA Ligase, Cytoplasmic 3
  • Asparagine TRNA Ligase 1 2
  • Cytoplasmic 2
  • NARS1 3

External Ids for NARS Gene

Previous GeneCards Identifiers for NARS Gene

  • GC18M055658
  • GC18M055242
  • GC18M055052
  • GC18M053416
  • GC18M053418
  • GC18M051978
  • GC18M055267

Summaries for NARS Gene

Entrez Gene Summary for NARS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARS Gene

NARS (Asparaginyl-TRNA Synthetase) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleic acid binding and asparagine-tRNA ligase activity.

Gene Wiki entry for NARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARS Gene

Genomics for NARS Gene

Regulatory Elements for NARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NARS Gene

Start:
57,600,656 bp from pter
End:
57,622,213 bp from pter
Size:
21,558 bases
Orientation:
Minus strand

Genomic View for NARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARS Gene

Proteins for NARS Gene

  • Protein details for NARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43776-SYNC_HUMAN
    Recommended name:
    Asparagine--tRNA ligase, cytoplasmic
    Protein Accession:
    O43776
    Secondary Accessions:
    • B4DG16
    • Q53GU6

    Protein attributes for NARS Gene

    Size:
    548 amino acids
    Molecular mass:
    62943 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARS Gene

Proteomics data for NARS Gene at MOPED

Post-translational modifications for NARS Gene

  • Ubiquitination at Lys60, Lys104, Lys445, Lys490, and Lys507
  • Modification sites at PhosphoSitePlus

Other Protein References for NARS Gene

Domains for NARS Gene

Gene Families for NARS Gene

HGNC:
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

Graphical View of Domain Structure for InterPro Entry

O43776

UniProtKB/Swiss-Prot:

SYNC_HUMAN :
  • O43776
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with NARS: view

Function for NARS Gene

Molecular function for NARS Gene

GENATLAS Biochemistry: asparaginyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

Enzyme Numbers (IUBMB) for NARS Gene

Gene Ontology (GO) - Molecular Function for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003676 nucleic acid binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004815 aspartate-tRNA ligase activity --
GO:0004816 asparagine-tRNA ligase activity IEA --
genes like me logo Genes that share ontologies with NARS: view

Phenotypes for NARS Gene

genes like me logo Genes that share phenotypes with NARS: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NARS Gene

Localization for NARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NARS Gene COMPARTMENTS Subcellular localization image for NARS gene
Compartment Confidence
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NARS: view

Pathways for NARS Gene

genes like me logo Genes that share pathways with NARS: view

Pathways by source for NARS Gene

1 KEGG pathway for NARS Gene

Gene Ontology (GO) - Biological Process for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006421 asparaginyl-tRNA aminoacylation IEA --
GO:0006422 aspartyl-tRNA aminoacylation --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with NARS: view

Compounds for NARS Gene

(5) HMDB Compounds for NARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Asparagine
  • (-)-Asparagine
70-47-3
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for NARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Asparagine
  • (-)-Asparagine
70-47-3 target

(4) Novoseek inferred chemical compound relationships for NARS Gene

Compound -log(P) Hits PubMed IDs
aminoacyl-trna 74.5 1
trna 73.1 13
asparagine 51.8 3
uranium 47.8 2
genes like me logo Genes that share compounds with NARS: view

Transcripts for NARS Gene

Unigene Clusters for NARS Gene

Asparaginyl-tRNA synthetase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NARS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NARS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for NARS Gene

GeneLoc Exon Structure for
NARS
ECgene alternative splicing isoforms for
NARS

Expression for NARS Gene

mRNA expression in normal human tissues for NARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NARS Gene

SOURCE GeneReport for Unigene cluster for NARS Gene Hs.465224

genes like me logo Genes that share expressions with NARS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NARS Gene

Orthologs for NARS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARS 35
  • 99.15 (n)
  • 99.45 (a)
NARS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 83 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
NARS 35
  • 87.65 (n)
  • 93.43 (a)
dog
(Canis familiaris)
Mammalia NARS 35
  • 90.94 (n)
  • 95.26 (a)
NARS 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nars 35
  • 86.68 (n)
  • 93.61 (a)
Nars 16
Nars 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NARS 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nars 35
  • 86.72 (n)
  • 93.05 (a)
chicken
(Gallus gallus)
Aves NARS 35
  • 79.87 (n)
  • 86.13 (a)
NARS 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARS 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nars 35
  • 74.88 (n)
  • 84.12 (a)
zebrafish
(Danio rerio)
Actinopterygii nars 35
  • 72.2 (n)
  • 81.75 (a)
nars 36
  • 81 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002969 35
  • 63.08 (n)
  • 72.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-asn 35
  • 62.17 (n)
  • 71.9 (a)
Aats-asn 36
  • 70 (a)
OneToOne
BcDNA:GH06451 37
  • 73 (a)
worm
(Caenorhabditis elegans)
Secernentea nars-1 35
  • 58.15 (n)
  • 58.82 (a)
nars-1 36
  • 58 (a)
OneToOne
nrs-1 37
  • 58 (a)
Y66D12A.23 37
  • 26 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL020W 35
  • 53.38 (n)
  • 52.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED81 35
  • 56.71 (n)
  • 53.43 (a)
DED81 36
  • 51 (a)
OneToOne
DED81 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08426g 35
  • 56.46 (n)
  • 53.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06457 35
  • 54.31 (n)
  • 50.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nrs1 35
  • 53.35 (n)
  • 50.93 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4788 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for NARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARS Gene

ENSEMBL:
Gene Tree for NARS (if available)
TreeFam:
Gene Tree for NARS (if available)

Paralogs for NARS Gene

Selected SIMAP similar genes for NARS Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for NARS Gene

genes like me logo Genes that share paralogs with NARS: view

No data available for Paralogs for NARS Gene

Variants for NARS Gene

Sequence variations from dbSNP and Humsavar for NARS Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs11356 -- 57,601,254(-) TACCT(G/T)GAATT utr-variant-3-prime
rs317817 -- 57,612,087(+) CTCCA(A/C)GGTTA intron-variant
rs317818 -- 57,613,893(+) TCTTA(A/G)TGTAA intron-variant
rs317819 -- 57,614,259(+) ACTTT(A/G)GGAGG intron-variant
rs317820 -- 57,614,808(+) TTACT(C/T)AACTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NARS Gene

Variant ID Type Subtype PubMed ID
esv2751777 CNV Gain 17911159
nsv458086 CNV Gain 19166990
nsv909663 CNV Gain 21882294
nsv833663 CNV Gain 17160897
nsv909664 CNV Loss 21882294

Relevant External Links for NARS Gene

HapMap Linkage Disequilibrium report
NARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARS Gene

Disorders for NARS Gene

(2) University of Copenhagen DISEASES for NARS Gene

(2) Novoseek inferred disease relationships for NARS Gene

Disease -log(P) Hits PubMed IDs
myopathies idiopathic inflammatory 69.5 1
myositis 62.1 1

Relevant External Links for NARS

Genetic Association Database (GAD)
NARS
Human Genome Epidemiology (HuGE) Navigator
NARS
genes like me logo Genes that share disorders with NARS: view

No data available for UniProtKB/Swiss-Prot for NARS Gene

Publications for NARS Gene

  1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PMID: 9421509) Beaulande M. … Haertlein M. (Nucleic Acids Res. 1998) 2 3 4 23
  2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PMID: 9801298) Shiba K. … Noda T. (Nucleic Acids Res. 1998) 3 4 23
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PMID: 6836455) Cirullo R.E. … Wasmuth J.J. (Somatic Cell Genet. 1983) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NARS Gene

Sources for NARS Gene

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