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NARS Gene

protein-coding   GIFtS: 69
GCID: GC18M055267

Asparaginyl-TRNA Synthetase

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Asparaginyl-TRNA Synthetase1 2 3     NARS12
EC 6.1.1.223 8     Asparagine TRNA Ligase 1, Cytoplasmic2
ASNRS2 5     Asparagine--TRNA Ligase, Cytoplasmic2
Asparagine TRNA Ligase 11     Asparaginyl-TRNA Synthetase, Cytoplasmic2
cytoplasmic1     AsnRS3

External Ids:    HGNC: 76431   Entrez Gene: 46772   Ensembl: ENSG000001344407   OMIM: 1084105   UniProtKB: O437763   

Export aliases for NARS gene to outside databases

Previous GC identifers: GC18M055658 GC18M055242 GC18M055052 GC18M053416 GC18M053418 GC18M051978


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NARS Gene:
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids.
Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases.
The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NARS Gene:
NARS (asparaginyl-tRNA synthetase) is a protein-coding gene. GO annotations related to this gene include asparagine-tRNA ligase activity and nucleic acid binding.

Gene Wiki entry for NARS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NARS gene promoter:
         CHOP-10   NRSF form 1   NRSF form 2   TGIF   GATA-1   C/EBPalpha   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNARS promoter sequence
   Search Chromatin IP Primers for NARS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.31   Ensembl cytogenetic band:  18q21.31   HGNC cytogenetic band: 18q21.31

NARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NARS gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18M055267:  view genomic region     (about GC identifiers)

Start:
55,267,888 bp from pter      End:
55,289,445 bp from pter
Size:
21,558 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SYNC_HUMAN, O43776 (See protein sequence)
Recommended Name: Asparagine--tRNA ligase, cytoplasmic  
Size: 548 amino acids; 62943 Da
Secondary accessions: Q53GU6

Explore the universe of human proteins at neXtProt for NARS: NX_O43776

Explore proteomics data for NARS at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys60, Lys104, Lys445, Lys490, Lys507
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NARS (O43776) (see all 8)
     VQTQVEGG  VEGGATLFK  LMFLVLRDG  GLGLERFLTWI 


    See NARS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004530.1  
    ENSEMBL proteins: 
     ENSP00000256854   ENSP00000464988   ENSP00000442496   ENSP00000467651   ENSP00000467421  
     ENSP00000466606   ENSP00000464899   ENSP00000466919   ENSP00000407919  
    Reactome Protein details: O43776

    NARS Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals NARS Proteins
    Novus Biologicals NARS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NARS
    Cloud-Clone Corp. Proteins for NARS

     
    Search eBioscience for Proteins for NARS 

     
    antibodies-online proteins for NARS (4 products) 

     
    antibodies-online peptides for NARS

    NARS Antibody Products:

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    LSBio Antibodies in human, mouse, rat for NARS
    antibodies-online antibodies for NARS (25 products) 

    NARS Assay Products:

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    Cloud-Clone Corp. ELISAs for NARS
    Cloud-Clone Corp. CLIAs for NARS
    Search eBioscience for ELISAs for NARS 
    antibodies-online kits for NARS (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    aaRS2: Aminoacyl tRNA synthetases / Class II

    Selected InterPro protein domains (see all 7):
     IPR004522 Asn-tRNA-ligase
     IPR006195 aa-tRNA-synth_II
     IPR004364 aa-tRNA-synt_II
     IPR012340 NA-bd_OB-fold
     IPR004365 NA-bd_OB_tRNA

    Graphical View of Domain Structure for InterPro Entry O43776

    ProtoNet protein and cluster: O43776

    3 Blocks protein domains:
    IPB002312 Aspartyl-tRNA synthetase signature
    IPB004364 tRNA synthetase
    IPB004365 OB-fold nucleic acid binding domain


    UniProtKB/Swiss-Prot: SYNC_HUMAN, O43776
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    Find genes that share domains with NARS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SYNC_HUMAN, O43776
    Catalytic activity: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)

         Genatlas biochemistry entry for NARS:
    asparaginyl-tRNA synthetase

         Enzyme Number (IUBMB): EC 6.1.1.221 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003676nucleic acid binding IEA--
    GO:0004812aminoacyl-tRNA ligase activity ----
    GO:0004816asparagine-tRNA ligase activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with NARS           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NARS:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NARS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NARS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NARS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NARS

    miRNA
    Products:
        
    miRTarBase miRNAs that target NARS:
    hsa-mir-222-3p (MIRT046695), hsa-mir-331-3p (MIRT043484), hsa-let-7f-5p (MIRT051384), hsa-mir-155-5p (MIRT001530), hsa-mir-16-5p (MIRT031806)

    Block miRNA regulation of human, mouse, rat NARS using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NARS:
    hsa-miR-370 hsa-miR-586 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidNARS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NARS
    Predesigned siRNA for gene silencing in human, mouse, rat NARS

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for NARS

    Clone
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    OriGene clones in human, mouse for NARS (see all 8)
    OriGene ORF clones in mouse, rat for NARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NARS (NM_004539)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARS

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NARS
    Browse ESI BIO Cell Lines and PureStem Progenitors for NARS 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SYNC_HUMAN, O43776: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with NARS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NARS About    
    See pathways by source

    SuperPathContained pathways About
    1tRNA Aminoacylation
    tRNA Aminoacylation0.57
    Aminoacyl-tRNA biosynthesis0.52
    Cytosolic tRNA aminoacylation0.57
    2Gene Expression
    Gene Expression0.40


    Find genes that share SuperPaths with NARS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for NARS
        Cytosolic tRNA aminoacylation


    1 Kegg Pathway  (Kegg details for NARS):
        Aminoacyl-tRNA biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NARS
    Interactions:

        Search GeneGlobe Interaction Network for NARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NARS (O437762, 3 ENSP000002568544) via UniProtKB, MINT, STRING, and/or I2D (see all 288)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006421asparaginyl-tRNA aminoacylation IEA--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with NARS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NARS (SYNC)

    5 HMDB Compounds for NARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for NARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Asparagine(-)-Asparagine (see all 15)70-47-3target--17380207 16753178

    4 Novoseek inferred chemical compound relationships for NARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 74.5 1 18285520 (1)
    trna 73.1 31 9421509 (3), 10993083 (2), 16800632 (2), 17393393 (2) (see all 7)
    asparagine 51.8 4 8636057 (2), 16408313 (1)
    uranium 47.8 2 10976874 (1), 16609186 (1)



    Find genes that share compounds with NARS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NARS gene: 
    NM_004539.3  

    Unigene Cluster for NARS:

    Asparaginyl-tRNA synthetase
    Hs.465224  [show with all ESTs]
    Unigene Representative Sequence: NM_004539
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256854(uc002lgs.2 uc010xea.1 uc010xeb.1 uc010xec.2 uc010xed.2)
    ENST00000589314 ENST00000586807 ENST00000589001 ENST00000411676 ENST00000540592
    ENST00000591599 ENST00000588661 ENST00000587675 ENST00000587194 ENST00000590123
    ENST00000587366 ENST00000423481
    miRNA
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    Block miRNA regulation of human, mouse, rat NARS using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NARS:
    hsa-miR-370 hsa-miR-586 hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidNARS 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NARS
    Predesigned siRNA for gene silencing in human, mouse, rat NARS
    Clone
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    OriGene clones in human, mouse for NARS (see all 8)
    OriGene ORF clones in mouse, rat for NARS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NARS (NM_004539)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARS
    Primer
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    OriGene qPCR primer pairs and template standards for NARS
    OriGene qSTAR qPCR primer pairs in human, mouse for NARS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NARS
      QuantiTect SYBR Green Assays in human, mouse, rat NARS
      QuantiFast Probe-based Assays in human, mouse, rat NARS

    Additional mRNA sequence: 

    AJ000334.1 AK129897.1 AK222835.1 AK293985.1 AK294364.1 AK294763.1 AK297777.1 BC001687.1 
    D84273.1 U79254.1 

    Selected DOTS entries (see all 29):

    DT.419312  DT.97855359  DT.102832966  DT.121084213  DT.100869391  DT.100673910  DT.100848843  DT.91722905 
    DT.100673905  DT.95083245  DT.92023625  DT.100673909  DT.100673906  DT.422320  DT.92404386  DT.121084198 
    DT.121084209  DT.91769789  DT.91769794  DT.95162534  DT.95162574  DT.121084181  DT.121084196  DT.121084218 

    Selected AceView cDNA sequences (see all 637):

    BG774073 AL701792 BM789162 AI915901 T24815 BX343744 BG761580 BM978485 
    BU627730 BQ447627 BM455370 BP360712 AL697751 CR609633 AA633228 AI669455 
    BQ212971 BQ375592 AW389505 AA350625 AW027895 BG482302 AU125130 BP353393 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NARS    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:                    -                                                                                       
    SP2:                    -                                                                                       
    SP3:                                                                                                            
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for NARS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTCTCAAT
    NARS Expression
    About this image


    NARS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Midbrain tegmentum
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Eye (Sensory Organs)
             Lens
    NARS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NARS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.465224
        Custom PCR Arrays for NARS
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NARS
    OriGene qSTAR qPCR primer pairs in human, mouse for NARS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NARS
    QuantiTect SYBR Green Assays in human, mouse, rat NARS
    QuantiFast Probe-based Assays in human, mouse, rat NARS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NARS gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nars1 , 5 asparaginyl-tRNA synthetase1, 5 86.68(n)1
    93.61(a)1
      18 (37.47 cM)5
    702231  NM_001142950.11  NP_001136422.11 
     644996655 
    chicken
    (Gallus gallus)
    Aves NARS1 asparaginyl-tRNA synthetase 79.87(n)
    86.13(a)
      426856  NM_001031400.1  NP_001026571.1 
    lizard
    (Anolis carolinensis)
    Reptilia NARS6
    asparaginyl-tRNA synthetase
    83(a)
    1 ↔ 1
    GL343213.1(2180349-2211378)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nars1 asparaginyl-tRNA synthetase 74.88(n)
    84.12(a)
      100379908  XM_002934442.2  XP_002934488.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nars1 asparaginyl-tRNA synthetase 72.2(n)
    81.75(a)
      568332  XM_691656.5  XP_696748.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH064513
    Aats-asn1
    asparagine-tRNA ligase3
    Asparaginyl-tRNA synthetase1
    73(a)3
    62.17(n)1
    71.9(a)1
      37C13
    351941  NM_136104.41  NP_609948.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nrs-13
    nars-11
    asparaginyl-tRNA synthetase3
    nars-11
    58(a)
    (best of 2)3
    58.15(n)1
    58.82(a)1
      I(7096171-7097360)3
    1724421  NM_001026234.41  NP_001021405.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DED81(YHR019C)4
    DED811
    Cytosolic asparaginyl-tRNA synthetase, required for more4
    DED811
    56.71(n)1
    53.43(a)1
      8(143558-141894)4
    8564121, 4  NP_011883.11, 4 


    ENSEMBL Gene Tree for NARS (if available)
    TreeFam Gene Tree for NARS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NARS gene
    2 SIMAP similar genes for NARS using alignment to 9 protein entries:     SYNC_HUMAN (see all proteins):
    DARS    NARS2

    Find genes that share paralogs with NARS           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NARS
    PGOHUM00000258790 PGOHUM00000258791 PGOHUM00000249690


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NARS (see all 671)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3178321,2
    C,H--55267553(-) AGACCG/AAGGCG 1 -- ds500110Minor allele frequency- A:0.06WA NA CSA 17
    rs1856522971,2
    --55267554(+) GCCTTC/GGTCTC 1 -- ds50010--------
    rs1899707261,2
    --55267835(+) AAAGCA/GTGAAC 1 -- ds50010--------
    rs729404021,2
    C,F--55267841(+) TGAACG/AAATGT 1 -- ds50017Minor allele frequency- A:0.12NA CSA WA EA 366
    rs739619231,2
    C--55267969(+) AAATCA/CACTAA 1 -- ut312Minor allele frequency- C:0.08WA 120
    rs1501356331,2
    C--55268061(+) TCAAA-/CCAGCC 1 -- ut310--------
    rs1808830371,2
    --55268128(+) TAATTA/CCTTAG 1 -- ut310--------
    rs1873857121,2
    --55268244(+) CTTCAA/CATCCT 1 -- ut310--------
    rs589500201,2
    --55268246(+) TCAAAA/TCCTTT 1 -- ut310--------
    rs1469429181,2
    --55268287(+) TTTCTA/GTGCCT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NARS (55267888 - 55289445 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NARS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909664CNV Loss21882294
    esv2751777CNV Gain17911159
    nsv909663CNV Gain21882294
    nsv833663CNV Gain17160897
    nsv458086CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NARS
    DNA2.0 Custom Variant and Variant Library Synthesis for NARS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 108410    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for NARS:
    Filariasis     Myositis

    Find genes that share disorders with NARS           About GenesLikeMe

    2 Novoseek inferred disease relationships for NARS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myopathies idiopathic inflammatory 69.5 2 16085368 (1)
    myositis 62.1 1 12235211 (1)

    Genetic Association Database (GAD): NARS
    Human Genome Epidemiology (HuGE) Navigator: NARS (1 document)

    Export disorders for NARS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NARS gene, integrated from 10 sources (see all 54):
    (articles sorted by number of sources associating them with NARS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PubMed id 9421509)1, 2, 3, 9 Beaulande M.... Haertlein M. (Nucleic Acids Res. 1998)
    2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PubMed id 9801298)1, 2, 9 Shiba K.... Noda T. (Nucleic Acids Res. 1998)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PubMed id 6836455)1, 3 Cirullo R.E....Wasmuth J.J. (Somatic Cell Genet. 1983)
    6. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4677 HGNC: 7643 AceView: NARS Ensembl:ENSG00000134440 euGenes: HUgn4677
    ECgene: NARS Kegg: 4677 H-InvDB: NARS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NARS Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NARS gene:
    Search GeneIP for patents involving NARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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