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Aliases for NARS Gene

Aliases for NARS Gene

  • Asparaginyl-TRNA Synthetase 2 3 4 5
  • EC 6.1.1.22 4 63
  • ASNRS 3 4
  • Asparaginyl-TRNA Synthetase, Cytoplasmic 3
  • Asparagine TRNA Ligase 1, Cytoplasmic 3
  • Asparagine TRNA Ligase 1 2
  • Cytoplasmic 2
  • NARS1 3

External Ids for NARS Gene

Previous GeneCards Identifiers for NARS Gene

  • GC18M055658
  • GC18M055242
  • GC18M055052
  • GC18M053416
  • GC18M053418
  • GC18M051978
  • GC18M055267

Summaries for NARS Gene

Entrez Gene Summary for NARS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARS Gene

NARS (Asparaginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with NARS include myositis. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleic acid binding and aminoacyl-tRNA ligase activity.

Gene Wiki entry for NARS Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARS Gene

Genomics for NARS Gene

Regulatory Elements for NARS Gene

Promoters for NARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NARS on UCSC Golden Path with GeneCards custom track

Genomic Location for NARS Gene

Chromosome:
18
Start:
57,600,656 bp from pter
End:
57,622,213 bp from pter
Size:
21,558 bases
Orientation:
Minus strand

Genomic View for NARS Gene

Genes around NARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARS Gene

Proteins for NARS Gene

  • Protein details for NARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43776-SYNC_HUMAN
    Recommended name:
    Asparagine--tRNA ligase, cytoplasmic
    Protein Accession:
    O43776
    Secondary Accessions:
    • B4DG16
    • Q53GU6

    Protein attributes for NARS Gene

    Size:
    548 amino acids
    Molecular mass:
    62943 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARS Gene

Proteomics data for NARS Gene at MOPED

Post-translational modifications for NARS Gene

  • Ubiquitination at Lys 60, Lys 104, Lys 445, Lys 490, and Lys 507
  • Modification sites at PhosphoSitePlus

Domains & Families for NARS Gene

Gene Families for NARS Gene

Graphical View of Domain Structure for InterPro Entry

O43776

UniProtKB/Swiss-Prot:

SYNC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with NARS: view

Function for NARS Gene

Molecular function for NARS Gene

GENATLAS Biochemistry:
asparaginyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

Enzyme Numbers (IUBMB) for NARS Gene

Gene Ontology (GO) - Molecular Function for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004816 asparagine-tRNA ligase activity IEA,TAS --
genes like me logo Genes that share ontologies with NARS: view
genes like me logo Genes that share phenotypes with NARS: view

Animal Model Products

miRNA for NARS Gene

miRTarBase miRNAs that target NARS

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARS Gene

Localization for NARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NARS Gene COMPARTMENTS Subcellular localization image for NARS gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with NARS: view

Pathways & Interactions for NARS Gene

genes like me logo Genes that share pathways with NARS: view

Pathways by source for NARS Gene

1 KEGG pathway for NARS Gene

Gene Ontology (GO) - Biological Process for NARS Gene

None

No data available for SIGNOR curated interactions for NARS Gene

Drugs & Compounds for NARS Gene

(5) Drugs for NARS Gene - From: HMDB, DrugBank, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(4) Additional Compounds for NARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with NARS: view

Transcripts for NARS Gene

Unigene Clusters for NARS Gene

Asparaginyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NARS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for NARS Gene

GeneLoc Exon Structure for
NARS
ECgene alternative splicing isoforms for
NARS

Expression for NARS Gene

mRNA expression in normal human tissues for NARS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NARS Gene



SOURCE GeneReport for Unigene cluster for NARS Gene Hs.465224

genes like me logo Genes that share expression patterns with NARS: view

Protein tissue co-expression partners for NARS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NARS Gene

Orthologs for NARS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NARS 35
  • 87.65 (n)
  • 93.43 (a)
-- 36
  • 83 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NARS 35
  • 90.94 (n)
  • 95.26 (a)
NARS 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nars 35
  • 86.68 (n)
  • 93.61 (a)
Nars 16
Nars 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NARS 35
  • 99.15 (n)
  • 99.45 (a)
NARS 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nars 35
  • 86.72 (n)
  • 93.05 (a)
oppossum
(Monodelphis domestica)
Mammalia NARS 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
chicken
(Gallus gallus)
Aves NARS 35
  • 79.87 (n)
  • 86.13 (a)
NARS 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARS 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nars 35
  • 74.88 (n)
  • 84.12 (a)
zebrafish
(Danio rerio)
Actinopterygii nars 35
  • 72.2 (n)
  • 81.75 (a)
nars 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06451 37
  • 73 (a)
Aats-asn 35
  • 62.17 (n)
  • 71.9 (a)
Aats-asn 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002969 35
  • 63.08 (n)
  • 72.26 (a)
worm
(Caenorhabditis elegans)
Secernentea nrs-1 37
  • 58 (a)
Y66D12A.23 37
  • 26 (a)
nars-1 35
  • 58.15 (n)
  • 58.82 (a)
nars-1 36
  • 58 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL020W 35
  • 53.38 (n)
  • 52.4 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08426g 35
  • 56.46 (n)
  • 53.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED81 35
  • 56.71 (n)
  • 53.43 (a)
DED81 36
  • 51 (a)
OneToOne
DED81 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4788 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06457 35
  • 54.31 (n)
  • 50.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nrs1 35
  • 53.35 (n)
  • 50.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 66 (a)
OneToOne
Species with no ortholog for NARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARS Gene

ENSEMBL:
Gene Tree for NARS (if available)
TreeFam:
Gene Tree for NARS (if available)

Paralogs for NARS Gene

(2) SIMAP similar genes for NARS Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for NARS Gene

genes like me logo Genes that share paralogs with NARS: view

No data available for Paralogs for NARS Gene

Variants for NARS Gene

Sequence variations from dbSNP and Humsavar for NARS Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs11356 -- 57,601,254(-) TACCT(G/T)GAATT utr-variant-3-prime
rs496489 -- 57,621,456(-) CCCTG(C/G)CCCGC intron-variant
rs368935 -- 57,621,647(-) TCCAG(C/T)CGGGT intron-variant
rs370726 -- 57,620,923(-) CCCAT(A/G)TTTTA intron-variant
rs317817 -- 57,612,087(+) CTCCA(A/C)GGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NARS Gene

Variant ID Type Subtype PubMed ID
esv2751777 CNV Gain 17911159
nsv458086 CNV Gain 19166990
nsv909663 CNV Gain 21882294
nsv833663 CNV Gain 17160897
nsv909664 CNV Loss 21882294

Variation tolerance for NARS Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NARS Gene

HapMap Linkage Disequilibrium report
NARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARS Gene

Disorders for NARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for NARS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myositis
  • inflammatory disorder of muscle
- elite association - COSMIC cancer census association via MalaCards
Search NARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NARS

Genetic Association Database (GAD)
NARS
Human Genome Epidemiology (HuGE) Navigator
NARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NARS
genes like me logo Genes that share disorders with NARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NARS Gene

Publications for NARS Gene

  1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PMID: 9421509) Beaulande M. … Haertlein M. (Nucleic Acids Res. 1998) 2 3 4 23 67
  2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PMID: 9801298) Shiba K. … Noda T. (Nucleic Acids Res. 1998) 3 23
  3. Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PMID: 6836455) Cirullo R.E. … Wasmuth J.J. (Somatic Cell Genet. 1983) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NARS Gene

Sources for NARS Gene

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