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Aliases for NARS Gene

Aliases for NARS Gene

  • Asparaginyl-TRNA Synthetase 2 3 4 5
  • Asparagine TRNA Ligase 1, Cytoplasmic 2 3
  • EC 6.1.1.22 4 58
  • ASNRS 3 4
  • Asparaginyl-TRNA Synthetase, Cytoplasmic 3
  • Asparagine--TRNA Ligase, Cytoplasmic 3
  • NARS1 3

External Ids for NARS Gene

Previous GeneCards Identifiers for NARS Gene

  • GC18M055658
  • GC18M055242
  • GC18M055052
  • GC18M053416
  • GC18M053418
  • GC18M051978
  • GC18M055267

Summaries for NARS Gene

Entrez Gene Summary for NARS Gene

  • Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARS Gene

NARS (Asparaginyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with NARS include Myositis. Among its related pathways are Photodynamic therapy-induced unfolded protein response and tRNA Aminoacylation. GO annotations related to this gene include nucleic acid binding and aminoacyl-tRNA ligase activity.

Gene Wiki entry for NARS Gene

Additional gene information for NARS Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARS Gene

Genomics for NARS Gene

Regulatory Elements for NARS Gene

Enhancers for NARS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H057649 1.3 Ensembl ENCODE dbSUPER 15.9 -27.9 -27860 1 GTF2F1 PKNOX1 JUN CEBPG BMI1 RAD21 BATF BRCA1 RFX5 RCOR1 NARS RNU6-742P HMGN1P30 ENSG00000267787 TRG-TCC5-1
GH18H057786 1.3 Ensembl ENCODE dbSUPER 15.7 -166.3 -166333 4 KLF1 ARNT JUN ZMYM3 FEZF1 RAD21 FOSL1 POLR2A FOS MAFK NARS RNU6-742P ATP8B1 MRPS17P7
GH18H057665 1.4 Ensembl ENCODE dbSUPER 11.5 -44.6 -44601 2 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT TCF12 GATA2 EGR1 SCRT2 ATF7 NARS TRG-TCC5-1 ENSG00000267787
GH18H057819 1.5 Ensembl ENCODE dbSUPER 10 -197.8 -197810 1 PKNOX1 ATF1 ARNT SIN3A FEZF1 BRCA1 TCF12 ATF7 RUNX3 SP3 RNU6-742P NARS ATP8B1 GC18M057807
GH18H057812 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10 -191.3 -191336 1 JUN USF2 CEBPB EP300 RFX5 JUND MAFF POLR2A RCOR1 KDM1A ATP8B1 RNU6-742P NARS GC18M057807
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NARS on UCSC Golden Path with GeneCards custom track

Promoters for NARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000103794 313 2201 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS

Genomic Location for NARS Gene

Chromosome:
18
Start:
57,600,656 bp from pter
End:
57,622,213 bp from pter
Size:
21,558 bases
Orientation:
Minus strand

Genomic View for NARS Gene

Genes around NARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARS Gene

Proteins for NARS Gene

  • Protein details for NARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43776-SYNC_HUMAN
    Recommended name:
    Asparagine--tRNA ligase, cytoplasmic
    Protein Accession:
    O43776
    Secondary Accessions:
    • B4DG16
    • Q53GU6

    Protein attributes for NARS Gene

    Size:
    548 amino acids
    Molecular mass:
    62943 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NARS Gene

    Alternative splice isoforms for NARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARS Gene

Selected DME Specific Peptides for NARS Gene

O43776:
  • LNLTPKGKQAPGGHELSCDFWEL
  • LMFLVLRDG
  • VEGGATLFK
  • TRCFRDHFFDRGY
  • VQTQVEGG
  • LTQSSQLYLETC
  • LTESVDVLMPNVGEIVGGSMR
  • GLGLERFLTWI

Post-translational modifications for NARS Gene

  • Ubiquitination at Lys60, Lys104, posLast=445445, posLast=490490, and posLast=507507
  • Modification sites at PhosphoSitePlus

Domains & Families for NARS Gene

Gene Families for NARS Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O43776

UniProtKB/Swiss-Prot:

SYNC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with NARS: view

Function for NARS Gene

Molecular function for NARS Gene

GENATLAS Biochemistry:
asparaginyl-tRNA synthetase
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

Enzyme Numbers (IUBMB) for NARS Gene

Phenotypes From GWAS Catalog for NARS Gene

Gene Ontology (GO) - Molecular Function for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004816 asparagine-tRNA ligase activity TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with NARS: view
genes like me logo Genes that share phenotypes with NARS: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NARS

CRISPR Products

miRNA for NARS Gene

miRTarBase miRNAs that target NARS

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NARS
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARS Gene

Localization for NARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NARS gene
Compartment Confidence
extracellular 5
cytosol 5
mitochondrion 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9421509
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NARS: view

Pathways & Interactions for NARS Gene

genes like me logo Genes that share pathways with NARS: view

Pathways by source for NARS Gene

1 KEGG pathway for NARS Gene

Gene Ontology (GO) - Biological Process for NARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006418 tRNA aminoacylation for protein translation TAS,IEA --
GO:0006421 asparaginyl-tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with NARS: view

No data available for SIGNOR curated interactions for NARS Gene

Drugs & Compounds for NARS Gene

(4) Drugs for NARS Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra Target 0
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
ATP Nutra Agonist 0

(5) Additional Compounds for NARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with NARS: view

Transcripts for NARS Gene

Unigene Clusters for NARS Gene

Asparaginyl-tRNA synthetase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NARS
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NARS Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for NARS Gene

GeneLoc Exon Structure for
NARS
ECgene alternative splicing isoforms for
NARS

Expression for NARS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NARS Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NARS Gene



Protein tissue co-expression partners for NARS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NARS Gene:

NARS

SOURCE GeneReport for Unigene cluster for NARS Gene:

Hs.465224

Evidence on tissue expression from TISSUES for NARS Gene

  • Nervous system(5)
  • Liver(4.7)
  • Intestine(4.6)
  • Kidney(3.8)
  • Skin(3.3)
  • Lung(3)
  • Spleen(2.9)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with NARS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARS Gene

Orthologs for NARS Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARS 33 34
  • 99.15 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 92 (a)
OneToMany
NARS 33
  • 87.65 (n)
-- 34
  • 83 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NARS 34 33
  • 90.94 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NARS 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nars 33
  • 86.72 (n)
mouse
(Mus musculus)
Mammalia Nars 33 16 34
  • 86.68 (n)
chicken
(Gallus gallus)
Aves NARS 34 33
  • 79.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARS 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nars 33
  • 74.88 (n)
zebrafish
(Danio rerio)
Actinopterygii nars 33 34
  • 72.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH06451 35
  • 73 (a)
Aats-asn 33 34
  • 62.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002969 33
  • 63.08 (n)
worm
(Caenorhabditis elegans)
Secernentea nars-1 33 34
  • 58.15 (n)
nrs-1 35
  • 58 (a)
Y66D12A.23 35
  • 26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DED81 33 34 36
  • 56.71 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08426g 33
  • 56.46 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL020W 33
  • 53.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 66 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU06457 33
  • 54.31 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nrs1 33
  • 53.35 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4788 33
Species where no ortholog for NARS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARS Gene

ENSEMBL:
Gene Tree for NARS (if available)
TreeFam:
Gene Tree for NARS (if available)

Paralogs for NARS Gene

(2) SIMAP similar genes for NARS Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for NARS Gene

genes like me logo Genes that share paralogs with NARS: view

No data available for Paralogs for NARS Gene

Variants for NARS Gene

Sequence variations from dbSNP and Humsavar for NARS Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000098934 -- 57,603,897(+) ACCCC(A/C)CAAAG intron-variant
rs1000124297 -- 57,618,551(+) GAGCT(A/G)CAAAA intron-variant
rs1000185149 -- 57,622,369(+) CGATT(C/T)TTCTG upstream-variant-2KB
rs1000211991 -- 57,616,177(+) ATCCC(A/T)GCACT intron-variant
rs1000302392 -- 57,603,530(+) AATAG(-/T)TTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NARS Gene

Variant ID Type Subtype PubMed ID
dgv203e215 CNV deletion 23714750
esv2751777 CNV gain 17911159
esv3328362 CNV duplication 20981092
nsv1134720 CNV deletion 24896259
nsv458086 CNV gain 19166990
nsv577032 CNV gain 21841781
nsv833663 CNV gain 17160897

Variation tolerance for NARS Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NARS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARS Gene

Disorders for NARS Gene

MalaCards: The human disease database

(1) MalaCards diseases for NARS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myositis
  • inflammatory disorder of muscle
- elite association - COSMIC cancer census association via MalaCards
Search NARS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NARS

Genetic Association Database (GAD)
NARS
Human Genome Epidemiology (HuGE) Navigator
NARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NARS
genes like me logo Genes that share disorders with NARS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NARS Gene

Publications for NARS Gene

  1. Human cytosolic asparaginyl-tRNA synthetase: cDNA sequence, functional expression in Escherichia coli and characterization as human autoantigen. (PMID: 9421509) Beaulande M … Härtlein M (Nucleic acids research 1998) 2 3 4 22 60
  2. Human asparaginyl-tRNA synthetase: molecular cloning and the inference of the evolutionary history of Asx-tRNA synthetase family. (PMID: 9801298) Shiba K … Noda T (Nucleic acids research 1998) 3 4 22 60
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Isolation and characterization of interspecific heat-resistant hybrids between a temperature-sensitive chinese hamster cell asparaginyl-tRNA synthetase mutant and normal human leukocytes: assignment of human asnS gene to chromosome 18. (PMID: 6836455) Cirullo RE … Wasmuth JJ (Somatic cell genetics 1983) 2 3 60

Products for NARS Gene

Sources for NARS Gene

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