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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NARG2 Gene

protein-coding   GIFtS: 45
GCID: GC15M060711

NMDA receptor regulated 2

 Explore 3 diseases affiliated with
NARG2 via our new
 Human Malady Compendium 
Biological research products
for NARG2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NMDA Receptor Regulated 21 2
BRCC11 2 3
FLJ118961
Breast Cancer Cell 12
NMDA Receptor-Regulated Gene 22
NMDA Receptor-Regulated Protein 22

External Ids:    HGNC: 298851   Entrez Gene: 796642   Ensembl: ENSG000001289157   OMIM: 6108355   UniProtKB: Q659A13   

Export aliases for NARG2 gene to outside databases

Previous GC identifers: GC15M058294 GC15M058431 GC15M058502 GC15M037534


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NARG2 gene promoter:
         Sox5   CUTL1   Nkx2-5   E4BP4   CREB   S8   deltaCREB   FOXJ2 (long isoform)   HFH-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNARG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NARG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NARG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q22.2

NARG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NARG2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M060711:  view genomic region     (about GC identifiers)

Start:
60,711,808 bp from pter      End:
60,771,359 bp from pter
Size:
59,552 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NARG2_HUMAN, Q659A1 (See protein sequence)
Recommended Name: NMDA receptor-regulated protein 2  
Size: 982 amino acids; 110011 Da
Subcellular location: Nucleus (By similarity)
Developmental stage: Expressed in fetal brain, kidney, liver and lung
Sequence caution: Sequence=AAH13684.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH20918.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI07428.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=AAQ88910.1;
Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites; Sequence=BAB13948.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=CAH18700.1; Type=Erroneous translation; Note=Wrong choice
of CDS;
Secondary accessions: B2RU08 Q05CT1 Q3B7W6 Q63HP4 Q658Q0 Q68CN8 Q6IPW7 Q6UX23 Q71H65 Q96CY5 Q9HAA2
Alternative splicing: 2 isoforms:  Q659A1-1   Q659A1-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for NARG2: NX_Q659A1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q659A1

  • NARG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001018099.1  NP_001263314.1  NP_078887.2  

    ENSEMBL proteins: 
     ENSP00000261520   ENSP00000453593   ENSP00000454162   ENSP00000452714   ENSP00000453820  
     ENSP00000452713   ENSP00000453303   ENSP00000453041   ENSP00000453783   ENSP00000452618  
     ENSP00000394009  

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    Uscn Proteins for NARG2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    NARG2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NARG2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR019535 NARG2_C

    Graphical View of Domain Structure for InterPro Entry Q659A1

    ProtoNet protein and cluster: Q659A1


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-498 hsa-miR-607 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-371-5p hsa-miR-1184 hsa-miR-124 hsa-miR-548x
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----


    NARG2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NARG2:
     Decreased homologous recombina 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NARG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for NARG2 (ENSP000002615204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELLENSP000002628094STRING: ENSP00000262809
    KIAA0947ENSP000002965644STRING: ENSP00000296564
    EAF1ENSP000003800544STRING: ENSP00000380054
    MED26ENSP000002633904STRING: ENSP00000263390
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NARG2
    Search CenterWatch for drugs/clinical trials and news about NARG2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NARG2 gene (3 alternative transcripts): 
    NM_001018089.2  NM_001276385.1  NM_024611.5  

    Unigene Cluster for NARG2:

    NMDA receptor regulated 2
    Hs.200943  [show with all ESTs]
    Unigene Representative Sequence: NM_024611
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261520(uc002agp.3) ENST00000558181 ENST00000558121 ENST00000561124
    ENST00000561328(uc002agq.4) ENST00000561144 ENST00000561114(uc010bgk.3)
    ENST00000558512(uc002agr.1) ENST00000558451 ENST00000560895 ENST00000561446
    ENST00000560668 ENST00000561087 ENST00000558654 ENST00000560072 ENST00000560406
    ENST00000560520 ENST00000439632(uc002ago.3)

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate NARG2 (see all 22):
    hsa-miR-498 hsa-miR-607 hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-371-5p hsa-miR-1184 hsa-miR-124 hsa-miR-548x
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional cDNA sequence: 

    AF502591.1 AK021958.1 AK055752.1 AK095389.1 AK127892.1 AL832046.1 AL833318.1 AY358546.1 
    BC013684.1 BC020918.1 BC071685.1 BC107427.1 BC140894.1 BC151844.1 BX647873.1 CR749852.1 

    20 DOTS entries:

    DT.100729320  DT.100822158  DT.40281265  DT.99978714  DT.121074890  DT.413740  DT.92421768  DT.121075020 
    DT.40132514  DT.70100757  DT.102825935  DT.92421766  DT.102825934  DT.121074816  DT.121074934  DT.75143122 
    DT.91661641  DT.95158927  DT.202469  DT.40132513 

    24/201 AceView cDNA sequences (see all 201):

    AA304986 BX341810 CR612429 AI698429 AW241209 BU675087 CR608429 CA773523 
    BQ478152 BG496916 AW090760 BU621663 AA811524 AW075583 BG113848 AK127892 
    AI684821 AW673230 CA435435 H75958 AI220201 AA765247 AI793057 AI657092 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NARG2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                    -     -                 -                                                                 -                 -                     
    SP2:                    -     -                                                                                   -                 -                     
    SP3:                    -                                                                                                                                 
    SP4:              -     -     -                                                                                                                           
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NARG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NARG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGGAAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NARG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NARG2

    SOURCE GeneReport for Unigene cluster: Hs.200943

    UniProtKB/Swiss-Prot: NARG2_HUMAN, Q659A1
    Tissue specificity: Expressed at low levels in lung and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NARG2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Narg21 , 5 NMDA receptor-regulated gene 21, 5 82.23(n)1
    78.74(a)1
      9 (38.58 cM)5
    936971  NM_145618.31  NP_663593.21 
     693979065 
    chicken
    (Gallus gallus)
    Aves NARG21 NMDA receptor regulated 2 61.16(n)
    49.67(a)
      415378  XM_413764.3  XP_413764.3 
    lizard
    (Anolis carolinensis)
    Reptilia NARG26
    --
    44(a)
    1 ↔ 1
    GL343428.1(525787-534853)
    zebrafish
    (Danio rerio)
    Actinopterygii narg21 NMDA receptor regulated 2 46.02(n)
    35.92(a)
      100005372  XM_001344415.2  XP_001344451.2 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    20(a)
    1 ↔ 1
    GroupUn.2174(1402-4950)


    ENSEMBL Gene Tree for NARG2 (if available)
    TreeFam Gene Tree for NARG2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NARG2 gene

    NARG2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NARG2
    PGOHUM00000261997 PGOHUM00000238096 PGOHUM00000245794


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1166 NCBI SNPs in NARG2 are shown (see all 1166    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504049761,2
    --60711342(+) GCACCC/TGGCCT 2 -- ds50010--------
    rs1167920921,2
    F,--60711343(+) CACCCG/AGCCTC 2 -- ds50011Minor allele frequency- A:0.13WA 118
    rs1383011981,2
    --60711353(+) CCAGTA/GCTGTA 2 -- ds50010--------
    rs1144518031,2
    F,--60711403(+) AAATAT/CTCCTT 2 -- ds50011Minor allele frequency- C:0.03WA 118
    rs601577991,2
    F,--60711470(+) AATCAC/TAGAAT 2 -- ds50011Minor allele frequency- T:0.06WA 118
    rs1926637711,2
    --60711556(+) AACCAC/GGCTAT 2 -- ds50010--------
    rs1431100541,2
    --60711608(+) CTTGAC/TTGTTT 2 -- ds50010--------
    rs14633301,2
    C,F,H,--60711772(+) AGTAGT/ACTGGA 2 -- ds500118Minor allele frequency- A:0.37NA PA NS EA WA CSA 926
    rs1150689081,2
    --60711812(+) ATGGAA/TAAATG 2 -- ut310--------
    rs1451039241,2
    --60711880(+) AATACA/GTTAAG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for NARG2 (60711808 - 60771359 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NARG2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NARG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NARG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NARG2 for disorders           About GeneDecksing

    OMIM gene information: 610835    OMIM disorders: --

    3 diseases for NARG2:    About MalaCards
    breast cancer    cerebritis    neuronitis


    Export disorders for NARG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NARG2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with NARG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development. (PubMed id 15606750)1, 2 Sugiura N.... Corriveau R.A. (2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. (PubMed id 11297529)1, 3 Sugiura N....Corriveau R.A. (2001)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79664 HGNC: 29885 AceView: NARG2 Ensembl:ENSG00000128915 euGenes: HUgn79664
    ECgene: NARG2 H-InvDB: NARG2

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for NARG2 Pharmacogenomics, SNPs, Pathways

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