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NARG2 Gene

protein-coding   GIFtS: 51

GC15M058502
NMDA receptor regulated 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
BRCC1 1, 2, 3
FLJ11896 1
OTTHUMP00000163651 2
Descriptions
NMDA receptor regulated 2 2
NMDA receptor-regulated gene 2 2
breast cancer cell 1 2
External Ids
HGNC: 298851
Entrez Gene: 796642
UniProtKB: Q659A13
Ensembl: ENSG000001289157
Search outside databases for aliases for NARG2 gene

Previous GC identifers: GC15M058294 GC15M058431

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the NARG2 gene  

Entrez Gene cytogenetic band: 15q22.2   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q22.2

NARG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M058502:     (about GC identifiers)

Start:
58,499,100 bp from pter
End:
58,558,636 bp from pter
Size:
59,537 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NARG2_HUMAN, Q659A1 (See protein sequence)
Recommended Name: NMDA receptor-regulated protein 2  
Size: 982 amino acids; 110011 Da
Subcellular location: Nucleus (By similarity)
Developmental stage: Expressed in fetal brain, kidney, liver and lung
Sequence caution: Sequence=AAH20918.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence;
Secondary accessions: Q05CT1 Q3B7W6 Q63HP4 Q658Q0 Q68CN8 Q6IPW7 Q6UX23 Q71H65 Q96CY5 Q9HAA2
Alternative splicing: 3 isoforms:  Q659A1-1   Q659A1-2   Q659A1-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001018099.1  NP_078887.2  


    ENSEMBL proteins: 
    ENSP00000261520 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (NARG2)
    Human Recombinant Proteins from Abnova (NARG2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    About this table

    Antibodies for NARG2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NARG2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (NARG2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (NARG2)
    Novus Biologicals Antibody for NARG2

    Assays for NARG2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro domain/family:
     IPR019535 NARG2_C


       GeneDecks  NARG2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q659A1

    ProtoNet protein and cluster: Q659A1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NARG2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): BC020918

                  Applied Biosystems Silencer® siRNAs for NARG2

                  Sigma-Aldrich siRNA for NARG2  
                         Sigma-Aldrich shRNA for NARG2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for NARG2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018089
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018089
                                     untagged cDNA clones in CMV expression vector (see all 3): BC020918 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_024611

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for NARG2 (ENSP000002615203) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NARG1ENSP000002965433STRING (score=.903)
    BARD1ENSP000002609473STRING (score=.755)
    BRCA1ENSP000003502833STRING (score=.711)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for NARG2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (NARG2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): BC020918

                  Sigma-Aldrich siRNA for NARG2  
                         Sigma-Aldrich shRNA for NARG2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001018089  NM_024611  

    REFSEQ mRNAs for NARG2 gene (2 alternative transcripts): 

    NM_001018089.1   NM_024611.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001018089  NM_024611  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001018089
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001018089
                                     untagged cDNA clones in CMV expression vector (see all 3): BC020918 

    Additional cDNA sequence: 

    AF502591.1 AK021958.1 AK055752.1 AK095389.1 AK127892.1 AL832046.1 AL833318.1 AY358546.1 
    BC013684.1 BC020918.1 BC071685.1 BC107427.1 BC140894.1 BC151844.1 BX647873.1 CR608429.1 
    CR612429.1 CR749852.1 

    20 DOTS entries:

    DT.100822158  DT.100729320  DT.40281265  DT.99978714  DT.121074890  DT.413740  DT.92421768  DT.121075020 
    DT.40132514  DT.70100757  DT.102825935  DT.92421766  DT.102825934  DT.121074816  DT.121074934  DT.40132513 
    DT.75143122  DT.91661641  DT.95158927  DT.202469 

    24/201 AceView cDNA sequences (see all 201 ):

    CR612429 BU675087 AW241209 H75958 AI793057 AK095389 AI220201 BU621663 
    BG113848 AW673230 AA765247 AI657092 CA435435 AW090760 CR608429 AA811524 
    AA304986 AK127892 AI684821 AW075583 BX341810 AI698429 BG496916 CA773523 

    highest scoring ESTs for NARG2:

    AA304986 AF502591 AI337917 AI680084 AI680099 AK055752 AK095389 AL832046 AY358546 BF184157 

    Unigene Cluster for NARG2:

    NMDA receptor regulated 2
    Hs.200943  [show with all ESTs]
    Unigene Representative Sequence: NM_024611


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NARG2 (see all 7 )

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b
    SP1:                    -     -                 -                                                                 -                 -                     
    SP2:                    -     -                                                                                   -                 -                     
    SP3:                    -                                                                                                                                 
    SP4:              -     -     -                                                                                                                           
    SP5:                                                                                                                                                      

    About this scheme

    ECgene alternative splicing isoforms for NARG2

    1 Ensembl transcript including schematic representation:
    ENST00000261520  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    NARG2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for NARG2

    1 / 2 / 3

    12 probe-sets matching NARG2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    61313_at2, 3 U95-C 1 1.00 1.00 0.48 1.51 AI680084 0.80 1.00 0.91 1

    80017_at2, 3 U95-D 1 1.00 1.00 0.00 0.79 AI680099 0.80 1.00 0.91 1
    65633_at2, 3 U95-C 1 1.00 1.00 0.48 1.12 AI337917 0.80 1.00 0.91 1

    68959_at2, 3 U95-D 2 1.00 0.97 0.76 0.61 AI688083 0.20 1.00 0.72 1

    235189_at2, 3 U133-B 1 1.00 1.00 -- -- BE780502 0.60 1.00 0.82 1

    228960_at2, 3 U133-B 1 1.00 1.00 -- -- AW105285 0.60 1.00 0.82 1

    218713_at2, 3 U133-A 1 1.00 1.00 -- -- NM_024611 0.60 1.00 0.82 1

    242639_at2, 3 U133-B 1 0.91 1.00 -- -- AW340004 0.20 1.00 0.72 1

    235189_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    228960_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218713_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    242639_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    GeneDecks  NARG2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCAGGGAAAT

    SOURCE GeneReport for Unigene cluster: Hs.200943

    UniProtKB/Swiss-Prot: NARG2_HUMAN, Q659A1
    Tissue specificity: Expressed at low levels in lung and testis

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for NARG2 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NARG21   -- NMDA receptor regulated 2 91.24(n)
    89.12(a)
    608993  XM_846787.1  XP_851880.1 
    chimpanzee
    (Pan troglodytes)
    NARG21   -- NMDA receptor regulated 2 99.25(n)
    99.08(a)
    453489  XM_001173299.1  XP_001173299.1 
    cow
    (Bos taurus)
    NARG21   -- NMDA receptor regulated 2 89.88(n)
    87.93(a)
    541255  NM_001076265.1  NP_001069733.1 
    rat
    (Rattus norvegicus)
    Narg21   -- NMDA receptor regulated 2 83.47(n)
    80.32(a)
    691379  XM_001075498.1  XP_001075498.1 
    mouse
    (Mus musculus)
    Narg21, 5 95
    NMDA receptor-regulated gene 21, 5 82.23(n)1
    78.74(a)1
    936971  NM_145618.31  NP_663593.21 
     AA4728335  AK0417725  (see all 18)
    About this table        Species with no ortholog for NARG2

    ENSEMBL Gene Tree for NARG2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/300 NCBI SNPs in NARG2 are shown (see all 300 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 103)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs30681,2
    A,C,F,H,O58502935(-) CCCTTA/GAAGTT 2 -- ut3118Minor allele frequency- G:0.24MN EA NA EU WA 3144
    rs37432671,2
    A,C,F,H58558581(-) TCTTTC/TTTGGG 2 -- ut517Minor allele frequency- T:0.28NA EU EA WA 554
    rs10466571,2
    C,F,H58503092(-) AAAAAC/ACAGTT 2 -- ut317Minor allele frequency- A:0.39MN NA EA WA 600
    rs14633301,2
    F,H58499064(+) AGTAGT/ACTGGA 2 -- ng517Minor allele frequency- A:0.44NA PA EU EA WA 672
    rs38095531,2
    H58529299(-) AAATTG/CAGAGT 2 Q/E mis14Minor allele frequency- C:0.00EU EA WA 416
    rs10631001,2
    C58521989(-) TGTTAC/TGGAGT 2 Y/Y syn1 ese30--------
    rs18694851,2
    A,C,F,H,O58533897(+) ACTACA/GTTCCT 2 -- int15Minor allele frequency- G:0.44MN EU EA WA 600
    rs9360131,2
    A,C,F,H,O58505557(-) GCATTG/CAGTCC 2 -- int116Minor allele frequency- C:0.34MN EU EA WA NA 1524
    rs20540361,2
    A,C,F,H,O58551286(+) AAAAAC/ACAAAA 2 -- int15Minor allele frequency- A:0.32MN EU EA WA 592
    rs18694841,2
    A,C,F,H,O58529355(+) GTAAAT/GTATTA 2 -- int19Minor allele frequency- G:0.46EA NA MN EU WA 740
    About this table

    HapMap Linkage Disequilibrium images for NARG2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610835

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for NARG2 gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 79664 HGNC: 29885 AceView: NARG2 Ensembl:ENSG00000128915 euGenes: HUgn79664
    ECgene: NARG2 H-InvDB: NARG2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for NARG2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for NARG2 Antibodies for NARG2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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