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NARG1L Gene

protein-coding GIFtS: 46

GC13P040784

NMDA receptor regulated 1-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ22054 ^¹
MGC40612 ^¹, ²
NAT2 ^³
OTTHUMP00000018320 ^²
PRO2435 ^¹

Descriptions
NARG1-like protein ^³
NMDA receptor regulated 1-like ^²
NMDA receptor regulated 1-like protein ^²

External Ids
HGNC: 26164¹
Entrez Gene: 79612²
UniProtKB: Q6N069³
Ensembl: ENSG00000172766⁷

Search outside databases for aliases for NARG1L gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: NARGL_HUMAN, Q6N069

Function: May belong to a complex displaying N-terminal acetyltransferase activity (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NARG1L gene

Entrez Gene cytogenetic band: 13q14.11 Ensembl cytogenetic band: 13q14.11 HGNC cytogenetic band: 13q14.11

NARG1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P040784: (about GC identifiers)

Start:	40,783,416 bp from pter
End:	40,849,162 bp from pter
Size:	65,747 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NARGL_HUMAN, Q6N069 (See protein sequence)

Recommended Name: NMDA receptor-regulated 1-like protein

Size: 864 amino acids; 101462 Da

Secondary accessions: Q5VSP9 Q6P2D5 Q8N5J3 Q8N870

Alternative splicing: 5 isoforms: Q6N069-1 Q6N069-2 Q6N069-3 Q6N069-4 Q6N069-5

REFSEQ proteins (3 alternative transcripts):

NP_001104268.1 NP_060997.2 NP_078837.3

ENSEMBL proteins:

ENSP00000386103 ENSP00000368674 ENSP00000326162 ENSP00000368716

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (NARG1L)
	Human Recombinant Proteins from Abnova (NARG1L)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	ISS	--
GO:0005667	transcription factor complex	ISS	--
GO:0005737	cytoplasm	ISS	--

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Antibodies for NARG1L:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NARG1L
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (NARG1L), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for NARG1L

Assays for NARG1L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6N069

ProtoNet protein and cluster: Q6N069

UniProtKB/Swiss-Prot: NARGL_HUMAN, Q6N069

Similarity: Contains 7 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NARG1L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001110798

Applied Biosystems Silencer® siRNAs for NARG1L

Sigma-Aldrich siRNA for NARG1L

Sigma-Aldrich shRNA for NARG1L

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NARG1L
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001110798
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001110798
untagged cDNA clones in CMV expression vector (see all 4): AK097224

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024561

UniProtKB/Swiss-Prot: NARGL_HUMAN, Q6N069

Function: May belong to a complex displaying N-terminal acetyltransferase activity (By similarity)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	ISS	--
GO:0016407	contributes to acetyltransferase activity	ISS	--
GO:0043022	contributes to ribosome binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006474	N-terminal protein amino acid acetylation	ISS	--
GO:0045893	positive regulation of transcription, DNA-dependent	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NARG1L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NARG1L)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001110798

Sigma-Aldrich siRNA for NARG1L

Sigma-Aldrich shRNA for NARG1L

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001110798 NM_018527 NM_024561

REFSEQ mRNAs for NARG1L gene (3 alternative transcripts):

NM_001110798.1 NM_018527.2 NM_024561.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001110798 NM_018527 NM_024561

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001110798
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001110798
                                 untagged cDNA clones in CMV expression vector (see all 4): AK097224

Additional cDNA sequence:

AK025707.1 AK097224.1 AK291248.1 AL833341.1 BC017099.1 BC028112.1 BC032318.1 BC064592.1

BC101719.1 BC101721.1 BC131581.1 BC143506.1 BX640665.1 CR627327.1

11 DOTS entries:

DT.429879 DT.102826114 DT.101976975 DT.75183263 DT.100014235 DT.91643798 DT.208091 DT.120781342

DT.91918139 DT.95236875 DT.97786033

24/71 AceView cDNA sequences (see all 71 ):

BC017099 AV659285 NM_018527 AK097224 BC064592 AW779504 NM_024561 W79572

BC032318 F12400 AA659554 AI768620 AW236957 BQ219010 BM454423 H62291

AW614604 BI858089 F10018 BQ024480 AI376437 BI838509 BU959055 BF222959

highest scoring ESTs for NARG1L:

AI376437 AA076278 AI052376 AK025707 AL833341 AV711733 AV721585 AW008367 AW072221 AW189187

Unigene Cluster for NARG1L:

NMDA receptor regulated 1-like

Hs.512914 [show with all ESTs]

Unigene Representative Sequence: CR627327

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NARG1L (see all 8 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	·	12c	·	12d	^	13a	·	13b	^	14a	·	14b	·	14c
SP1:							-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NARG1L

4 Ensembl transcripts including schematic representations:

ENST00000403412 ENST00000379367 ENST00000325763 ENST00000379406

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NARG1L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NARG1L

¹ / ² / ³

5 probe-sets matching NARG1L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
46556_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.03	AI376437	1.00	1.00	1.00	1
63447_at²^{, 3}	U95-C	1	1.00	1.00	0.92	0.98	T74503	0.60	1.00	0.82	1
219378_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024561	0.60	1.00	0.82	1
219378_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555450_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NARG1L for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TTCAGAACCT

SOURCE GeneReport for Unigene cluster: Hs.512914

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for NARG1L gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NARG1L¹	--	NMDA receptor regulated 1-like	94.02(n) 96.46(a)	485464 XM_542583.2 XP_542583.2
chimpanzee (Pan troglodytes)	NARG1L¹	--	NMDA receptor regulated 1-like	99.54(n) 99.54(a)	467269 XM_001150675.1 XP_001150675.1
mouse (Mus musculus)	Narg1l^{1, 5}	14⁵	NMDA receptor regulated 1-like^{1, 5}	87.58(n)¹ 88.19(a)¹	66897¹ NM_025832.2¹ NP_080108.1¹ AI006752⁵ AK005056⁵ (see all 11)
chicken (Gallus gallus)	NARG1L¹	--	NMDA receptor regulated 1-like	84.26(n) 89(a)	418832 XM_417028.2 XP_417028.2
baker's yeast (Saccharomyces cerevisiae)	NAT1(YDL040C)⁴	4(381435-378871)	Subunit of the N-terminal acetyltransferase NatA (Nat1p, more	--	851521 NP_010244.1

About this table Species with no ortholog for NARG1L

ENSEMBL Gene Tree for NARG1L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NARG1L gene

NARG1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/418 NCBI SNPs in NARG1L are shown (see all 418 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 125)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3355^1,2	C,F,H,O	40849013(-)	`TTTGTC/GTTAAT`	1	--	ut3¹		13		MN NA EU EA WA	1348
	rs6560982^1,2	A,C,F,H	40847804(+)	`CCAGGT/GTGCAT`	1	--	ut3¹		7		NA EU EA WA	558
	rs17062054^1,2	C,F,H	40827296(+)	`CCAGGA/GACTTG`	3	E/G G/G	mis¹ syn¹		7		NA EU EA WA	560
	rs9315837^1,2	C,F,H	40848643(+)	`TGTTGC/AATATT`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs9315836^1,2	A,F,H	40848562(+)	`AGGGTG/ACTCTA`	1	--	ut3¹ ese³		4		EU EA WA	416
	rs9315838^1,2	C,F,H	40849323(+)	`TGCTGC/TAGTAG`	1	--	ng3¹		4		EU EA WA	414
	rs2483097^1,2	C,F,H	40782844(+)	`TAAATA/GTTTGT`	2	--	ng5¹ tfbs³		4		EU EA WA	416
--	rs2501948^1,2	A,C	40782666(-)	`accacA/Gcccgg`	2	--	ng5¹		0	--	--	--	--
--	rs9315834^1,2	A,C	40848278(+)	`AAAATC/TAGCCA`	1	--	ut3¹		0	--	--	--	--
	rs9566758^1,2	F,H	40847962(+)	`CGATCG/ACTTCT`	1	--	ut3¹ ese³		4		EU EA WA	414

About this table

HapMap Linkage Disequilibrium images for NARG1L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for NARG1L gene:

The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)^{2, 3} Yu Y....He F. (2001)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)³ Barrios-Rodiles M....Wrana J.L. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 79612	HGNC: 26164	AceView: FLJ22054	Ensembl:ENSG00000172766	euGenes: HUgn79612
ECgene: NARG1L	H-InvDB: NARG1L

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for NARG1L
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NARG1L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NARG1L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NARG1L		Antibodies for NARG1L
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
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	"Your Favorite Gene" Pathways		feedback

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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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NARG1L Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for NARG1L

Summaries
for NARG1L

Genomic Location
for NARG1L

Proteins
for NARG1L

Protein Domains/
Families
for NARG1L

Gene Function
for NARG1L

Pathways & Interactions
for NARG1L

Drugs & Compounds
for NARG1L

Transcripts
for NARG1L

Expression
for NARG1L

Orthologs
for NARG1L

Paralogs
for NARG1L

SNPs/Variants
for NARG1L

Disorders & Mutations
for NARG1L

Medical News
for NARG1L

Publications
for NARG1L

Search for NARG1L

Genome Databases showing NARG1L

Other Databases showing NARG1L

Specialized Databases showing NARG1L

Licensable Technologies
for NARG1L

Services
for NARG1L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NARG1L Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor NARG1L

Summariesfor NARG1L

Genomic Locationfor NARG1L

Proteinsfor NARG1L

Protein Domains/Familiesfor NARG1L

Gene Functionfor NARG1L

Pathways & Interactionsfor NARG1L

Drugs & Compoundsfor NARG1L

Transcriptsfor NARG1L

Expression for NARG1L

Orthologsfor NARG1L

Paralogsfor NARG1L

SNPs/Variantsfor NARG1L

Disorders & Mutationsfor NARG1L

Medical Newsfor NARG1L

Publicationsfor NARG1L

Search for NARG1L

Genome Databases showing NARG1L

Other Databases showing NARG1L

Specialized Databases showing NARG1L

Licensable Technologiesfor NARG1L

Servicesfor NARG1L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NARG1L

Summaries
for NARG1L

Genomic Location
for NARG1L

Proteins
for NARG1L

Protein Domains/
Families
for NARG1L

Gene Function
for NARG1L

Pathways & Interactions
for NARG1L

Drugs & Compounds
for NARG1L

Transcripts
for NARG1L

Expression
for NARG1L

Orthologs
for NARG1L

Paralogs
for NARG1L

SNPs/Variants
for NARG1L

Disorders & Mutations
for NARG1L

Medical News
for NARG1L

Publications
for NARG1L

Licensable Technologies
for NARG1L

Services
for NARG1L