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Aliases & Descriptions for NARG1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ13340 1 | | GA19 3 | | Ga19 2 | | NATH 1, 2, 3 | | TBDN100 1, 2, 3 | | Tbdn100 3 | | tubedown-1 2 |
| | | Descriptions |
|---|
| Gastric cancer antigen Ga19 2, 3 | | N-terminal acetyltransferase 3 | | NMDA receptor regulated 1 2 | | Protein tubedown-1 3 | | transcriptional coactivator tubedown-100 2 |
|
| | Search outside databases for aliases for NARG1 genePrevious GC identifer: GC04P140581 |
Summaries for NARG1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NARG1: This gene encodes a protein of unknown function. However, similarity to proteins in yeast and other species suggests that this protein may be an N-acetyltransferase. [provided by RefSeq] UniProtKB/Swiss-Prot: NARG1_HUMAN, Q9BXJ9Function: The ARD1A-NARG1 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with G22P1 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoterGene Wiki entry for NARG1 |
Genomic Location for NARG1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NARG1 gene 
Entrez Gene cytogenetic band: 4q31.1 Ensembl cytogenetic band: 4q31.1 HGNC cytogenetic band: 4q31.1NARG1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P140442:
(about GC identifiers)
Start:
|
140,442,126 bp from pter |
End:
|
140,531,972 bp from pter |
Size:
|
89,847 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for NARG1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NARG1_HUMAN, Q9BXJ9 (See
protein sequence)Recommended Name: NMDA receptor-regulated protein 1 Size: 866 amino acids; 101272 Da
Subunit: Interacts with ARD1A, G22P1, NAT13 and XRCC5
Subcellular location: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes
Sequence caution: Sequence=AAH39818.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: Q52LG9 Q8IWH4 Q8NEV2 Q9H8P6Alternative splicing: 2 isoforms: Q9BXJ9-1 Q9BXJ9-4 Post-translational modifications:
Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_476516.1
ENSEMBL proteins: ENSP00000381920 ENSP00000296543
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NARG1: Assays for NARG1: | Protein
Domains/ Families for NARG1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BXJ9
ProtoNet protein and cluster: Q9BXJ9 1 Blocks protein family: IPB002197 FIS bacterial regulatory protein HTH signature
UniProtKB/Swiss-Prot: NARG1_HUMAN, Q9BXJ9Similarity: Contains 8 TPR repeats | Gene Function for NARG1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_057175
Applied Biosystems Silencer® siRNAs for NARG1
Sigma-Aldrich siRNA for NARG1  Sigma-Aldrich shRNA for NARG1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_057175                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_057175                                  untagged cDNA clone in CMV expression vector: NM_057175 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_057175
UniProtKB/Swiss-Prot: NARG1_HUMAN, Q9BXJ9Function: The ARD1A-NARG1 complex displays alpha (N-terminal) acetyltransferase activity that may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with G22P1 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for NARG1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for NARG1 
5/27 Interacting proteins for NARG1 (ENSP000002965433) via UniProtKB, MINT, and/or STRING (see all 27
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for NARG1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NARG1 1 Novoseek chemical compound relationship for NARG1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| n-atc |
87.47 |
1 |
15911569 (1) |
About this table
|
Transcripts for NARG1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_057175
Sigma-Aldrich siRNA for NARG1  Sigma-Aldrich shRNA for NARG1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_057175 REFSEQ mRNAs for NARG1 gene: NM_057175.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_057175               OriGene GFP tagged cDNA clone in CMV expression vector: NM_057175                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_057175                                  untagged cDNA clone in CMV expression vector: NM_057175  Additional cDNA sequence: AF327722.1 AJ314788.1 AK001595.1 AK023387.1 AK023402.1 AK091308.1 AK304417.1 AK314626.1 AY039242.1 AY112670.1 BC032642.1 BC039818.1 BC093928.1 BC104806.1 CR614926.1 9 DOTS entries: DT.100647925 DT.100783125 DT.436409 DT.97847843 DT.99939452 DT.206919 DT.86851419 DT.121255691 DT.92005232 24/148 AceView cDNA sequences (see all 148
):CR614926 AK001595 BM463359 BQ214565 BQ778193 AL556909 BX116461 AA845552 BC039818 AI208602 AW294949 AA707217 AA907375 AU119807 BM456794 NM_057175 AU130763 BM724518 BX647018 AA761423 BX111747 AA039428 NM_025085 AI744486
highest scoring ESTs for NARG1:AI765009 AI804279 AA019448 AA164640 AA214450 AA281004 AA281269 AA329697 AA907375 AA933795 Unigene Cluster for NARG1: NMDA receptor regulated 1 Hs.715706 [show with all ESTs]Unigene Representative Sequence: NM_057175
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NARG1 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | |
| SP1: | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |
| SP5: | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NARG1
2 Ensembl transcripts including schematic representations: ENST00000398947
ENST00000296543
|
Expression for NARG1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NARG1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NARG1
1 / 2 / 3 15 probe-sets matching NARG1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTGACAAAG
SOURCE GeneReport for Unigene cluster: Hs.715706 UniProtKB/Swiss-Prot: NARG1_HUMAN, Q9BXJ9Tissue specificity: Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy |
Orthologs for NARG1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NARG1 gene from 5/14 species (see all 14
)
About this table Species with no ortholog for NARG1
ENSEMBL Gene Tree for NARG1 | Paralogs for NARG1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NARG1 gene
- NARG1L2
|
SNPs/Variants for NARG1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NARG1 (up to first 250kb)
|
Disorders & Mutations for NARG1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608000
2 Novoseek disease relationships for NARG1 gene
About this table
|
Medical News for NARG1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NARG1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/32 PubMed articles for NARG1 gene (see all 32
):- NATH, a novel gene overexpressed in papillary thyroid carcinomas. (PubMed id 12140756)1, 2, 3, 4 Fluge O.... Lillehaug J.R. (2002)
- Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. (PubMed id 15496142)1, 3, 4 Arnesen T....Lillehaug J.R. (2005)
- Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex. (PubMed id 12145306)1, 3, 4 Willis D.M.... Towler D.A. (2002)
- A novel Xenopus acetyltransferase with a dynamic expression in early development. (PubMed id 11478804)1, 2, 3 Choi S.C....Han J.K. (2001)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)3, 4 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Cloning and analysis of a novel gene encoding N-terminal acetyltransferase subunit. (PubMed id 12019451)3, 4 He Y.G.... Tan D.Y. (2002)
- Serological identification and expression analysis of gastric cancer-associated genes. (PubMed id 12087473)3, 4 Line A....Rees R.C. (2002)
|
Search for NARG1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NARG1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NARG1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NARG1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NARG1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NARG1:

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Incremental update: 13 Oct 2009
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