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Aliases for NARFL Gene

Aliases for NARFL Gene

  • Nuclear Prelamin A Recognition Factor-Like 2 3
  • Iron-Only Hydrogenase-Like Protein 1 2 3 4
  • IOP1 3 4 6
  • Protein Related To Narf 3 4
  • PRN 3 4
  • Nuclear Prelamin A Recognition Factor-Like Protein 4
  • Cytosolic Fe-S Cluster Assembly Factor NARFL 3
  • LET1 Like/JFP15 3
  • LET1L 3
  • HPRN 3

External Ids for NARFL Gene

Previous GeneCards Identifiers for NARFL Gene

  • GC16U990170
  • GC16M000720
  • GC16M000721
  • GC16M000722
  • GC16M000781
  • GC16M000701
  • GC16M000782
  • GC16M000783
  • GC16M000784
  • GC16M000785
  • GC16M000787
  • GC16M000794
  • GC16M000796

Summaries for NARFL Gene

GeneCards Summary for NARFL Gene

NARFL (Nuclear Prelamin A Recognition Factor-Like) is a Protein Coding gene. Diseases associated with NARFL include pertussis. Among its related pathways are Metabolism and Cytosolic Iron-sulfur Cluster Assembly. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding. An important paralog of this gene is NARF.

UniProtKB/Swiss-Prot for NARFL Gene

  • Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARFL Gene

Genomics for NARFL Gene

Regulatory Elements for NARFL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NARFL Gene

Start:
729,753 bp from pter
End:
741,329 bp from pter
Size:
11,577 bases
Orientation:
Minus strand

Genomic View for NARFL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NARFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARFL Gene

Proteins for NARFL Gene

  • Protein details for NARFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Q4-NARFL_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NARFL
    Protein Accession:
    Q9H6Q4
    Secondary Accessions:
    • A1L385
    • B3KTJ3
    • Q53GC6
    • Q96S10
    • Q9H6J8

    Protein attributes for NARFL Gene

    Size:
    476 amino acids
    Molecular mass:
    53020 Da
    Quaternary structure:
    • Component of the CIA complex.
    SequenceCaution:
    • Sequence=AAK61251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NARFL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARFL Gene

Proteomics data for NARFL Gene at MOPED

Post-translational modifications for NARFL Gene

  • Ubiquitination at Lys342 and Lys347
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NARFL Gene

Domains for NARFL Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6Q4

UniProtKB/Swiss-Prot:

NARFL_HUMAN :
  • Q9H6Q4
Family:
  • Belongs to the NARF family.
genes like me logo Genes that share domains with NARFL: view

No data available for Gene Families for NARFL Gene

Function for NARFL Gene

Molecular function for NARFL Gene

UniProtKB/Swiss-Prot Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

Gene Ontology (GO) - Molecular Function for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NOT NADH dehydrogenase activity IBA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IBA --
GO:0051539 4 iron, 4 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with NARFL: view

Phenotypes for NARFL Gene

MGI mutant phenotypes for NARFL:
inferred from 2 alleles
genes like me logo Genes that share phenotypes with NARFL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NARFL

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NARFL Gene

Localization for NARFL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NARFL Gene COMPARTMENTS Subcellular localization image for NARFL gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097361 CIA complex IDA 22678361
genes like me logo Genes that share ontologies with NARFL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NARFL Gene

Pathways for NARFL Gene

genes like me logo Genes that share pathways with NARFL: view

Pathways by source for NARFL Gene

2 Reactome pathways for NARFL Gene

Gene Ontology (GO) - Biological Process for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 16956324
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006355 regulation of transcription, DNA-templated IDA 16956324
GO:0016226 iron-sulfur cluster assembly IMP 18270200
GO:0032364 oxygen homeostasis IDA 16956324
genes like me logo Genes that share ontologies with NARFL: view

Transcripts for NARFL Gene

Unigene Clusters for NARFL Gene

Nuclear prelamin A recognition factor-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NARFL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NARFL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - - -
SP8:
SP9:
SP10: -

Relevant External Links for NARFL Gene

GeneLoc Exon Structure for
NARFL
ECgene alternative splicing isoforms for
NARFL

Expression for NARFL Gene

mRNA expression in normal human tissues for NARFL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NARFL Gene

SOURCE GeneReport for Unigene cluster for NARFL Gene Hs.513247

mRNA Expression by UniProt/SwissProt for NARFL Gene

Q9H6Q4-NARFL_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with NARFL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NARFL Gene

Orthologs for NARFL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NARFL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARFL 35
  • 99.3 (n)
  • 99.58 (a)
NARFL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NARFL 35
  • 84.73 (n)
  • 85.5 (a)
NARFL 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NARFL 35
  • 83.82 (n)
  • 86.13 (a)
NARFL 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Narfl 35
  • 83.33 (n)
  • 87.61 (a)
Narfl 16
Narfl 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NARFL 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NARFL 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Narfl 35
  • 83.68 (n)
  • 86.13 (a)
chicken
(Gallus gallus)
Aves NARFL 35
  • 70.1 (n)
  • 71.64 (a)
NARFL 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARFL 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia narfl 35
  • 71.64 (n)
  • 71.64 (a)
zebrafish
(Danio rerio)
Actinopterygii narfl 35
  • 65.97 (n)
  • 68.07 (a)
narfl 36
  • 68 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NARF_ANOGA 35
  • 59.24 (n)
  • 52.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17683 35
  • 53.78 (n)
  • 49.68 (a)
CG17683 36
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea oxy-4 36
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAR1 36
  • 31 (a)
OneToMany
NAR1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16440 35
  • 51.42 (n)
  • 48.8 (a)
rice
(Oryza sativa)
Liliopsida Os03g0748700 35
  • 52.33 (n)
  • 49.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1190 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for NARFL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARFL Gene

ENSEMBL:
Gene Tree for NARFL (if available)
TreeFam:
Gene Tree for NARFL (if available)

Paralogs for NARFL Gene

Paralogs for NARFL Gene

Selected SIMAP similar genes for NARFL Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NARFL: view

Variants for NARFL Gene

Sequence variations from dbSNP and Humsavar for NARFL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2071951 -- 733,004(+) ACTCA(C/T)GGGAG intron-variant
rs2071952 -- 733,173(+) ACGCA(C/T)GCGAG intron-variant
rs3752556 -- 739,761(+) CCCAA(A/G)TCAGC intron-variant
rs3829492 -- 731,633(+) AACAC(A/G)TGCTC reference, synonymous-codon
rs4984688 -- 735,717(+) GGACC(C/T)GGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NARFL Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
dgv2495n71 CNV Loss 21882294
nsv904812 CNV Loss 21882294
dgv2497n71 CNV Loss 21882294

Relevant External Links for NARFL Gene

HapMap Linkage Disequilibrium report
NARFL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARFL Gene

Disorders for NARFL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NARFL Gene including...

Search for NARFL Gene in MalaCards »

Relevant External Links for NARFL

Genetic Association Database (GAD)
NARFL
genes like me logo Genes that share disorders with NARFL: view

No data available for UniProtKB/Swiss-Prot for NARFL Gene

Publications for NARFL Gene

  1. IOP1, a novel hydrogenase-like protein that modulates hypoxia- inducible factor-1alpha activity. (PMID: 16956324) Huang J. … Lee F.S. (Biochem. J. 2007) 2 3 4
  2. A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis. (PMID: 18270200) Song D. … Lee F.S. (J. Biol. Chem. 2008) 3 4
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis. (PMID: 19864422) Song D. … Lee F.S. (J. Biol. Chem. 2009) 3 23

Products for NARFL Gene

Sources for NARFL Gene

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