Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NARFL Gene

Aliases for NARFL Gene

  • Nuclear Prelamin A Recognition Factor Like 2 3
  • Nuclear Prelamin A Recognition Factor-Like 2 3 5
  • Iron-Only Hydrogenase-Like Protein 1 2 3 4
  • Protein Related To Narf 3 4
  • IOP1 3 4
  • PRN 3 4
  • Nuclear Prelamin A Recognition Factor-Like Protein 4
  • LET1 Like/JFP15 3
  • LET1L 3
  • HPRN 3

External Ids for NARFL Gene

Previous GeneCards Identifiers for NARFL Gene

  • GC16U990170
  • GC16M000720
  • GC16M000721
  • GC16M000722
  • GC16M000781
  • GC16M000701
  • GC16M000782
  • GC16M000783
  • GC16M000784
  • GC16M000785
  • GC16M000787
  • GC16M000794
  • GC16M000796
  • GC16M000808
  • GC16M000826

Summaries for NARFL Gene

GeneCards Summary for NARFL Gene

NARFL (Nuclear Prelamin A Recognition Factor Like) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and NADH dehydrogenase activity. An important paralog of this gene is NARF.

UniProtKB/Swiss-Prot for NARFL Gene

  • Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARFL Gene

Genomics for NARFL Gene

Regulatory Elements for NARFL Gene

Enhancers for NARFL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NARFL on UCSC Golden Path with GeneCards custom track

Promoters for NARFL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NARFL on UCSC Golden Path with GeneCards custom track

Genomic Location for NARFL Gene

729,753 bp from pter
741,329 bp from pter
11,577 bases
Minus strand

Genomic View for NARFL Gene

Genes around NARFL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARFL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARFL Gene

Proteins for NARFL Gene

  • Protein details for NARFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NARFL
    Protein Accession:
    Secondary Accessions:
    • A1L385
    • B3KTJ3
    • Q53GC6
    • Q96S10
    • Q9H6J8

    Protein attributes for NARFL Gene

    476 amino acids
    Molecular mass:
    53020 Da
    Quaternary structure:
    • Component of the CIA complex.
    • Sequence=AAK61251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NARFL Gene


neXtProt entry for NARFL Gene

Proteomics data for NARFL Gene at MOPED

Post-translational modifications for NARFL Gene

  • Ubiquitination at Lys 342
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NARFL Gene

Domains & Families for NARFL Gene

Protein Domains for NARFL Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NARF family.
  • Belongs to the NARF family.
genes like me logo Genes that share domains with NARFL: view

No data available for Gene Families for NARFL Gene

Function for NARFL Gene

Molecular function for NARFL Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

Phenotypes for NARFL Gene

genes like me logo Genes that share phenotypes with NARFL: view

Animal Models for NARFL Gene

MGI Knock Outs for NARFL:

Animal Model Products

  • Taconic Biosciences Mouse Models for NARFL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NARFL Gene

Localization for NARFL Gene

Subcellular locations from

Jensen Localization Image for NARFL Gene COMPARTMENTS Subcellular localization image for NARFL gene
Compartment Confidence
cytosol 5
nucleus 3
endosome 2
plasma membrane 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NARFL Gene

Pathways & Interactions for NARFL Gene

genes like me logo Genes that share pathways with NARFL: view

Pathways by source for NARFL Gene

2 Reactome pathways for NARFL Gene

Gene Ontology (GO) - Biological Process for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 16956324
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with NARFL: view

No data available for SIGNOR curated interactions for NARFL Gene

Drugs & Compounds for NARFL Gene

No Compound Related Data Available

Transcripts for NARFL Gene

Unigene Clusters for NARFL Gene

Nuclear prelamin A recognition factor-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NARFL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP6: - - - - - -
SP7: - - - - - -
SP10: -

Relevant External Links for NARFL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NARFL Gene

mRNA expression in normal human tissues for NARFL Gene

Protein differential expression in normal tissues from HIPED for NARFL Gene

This gene is overexpressed in Lymph node (8.9), Retina (7.6), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NARFL Gene

SOURCE GeneReport for Unigene cluster for NARFL Gene Hs.513247

mRNA Expression by UniProt/SwissProt for NARFL Gene

Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with NARFL: view

Protein tissue co-expression partners for NARFL Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NARFL Gene

Orthologs for NARFL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NARFL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NARFL 35
  • 84.73 (n)
  • 85.5 (a)
  • 86 (a)
(Canis familiaris)
Mammalia NARFL 35
  • 83.82 (n)
  • 86.13 (a)
  • 86 (a)
(Mus musculus)
Mammalia Narfl 35
  • 83.33 (n)
  • 87.61 (a)
Narfl 16
Narfl 36
  • 88 (a)
(Pan troglodytes)
Mammalia NARFL 35
  • 99.3 (n)
  • 99.58 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Narfl 35
  • 83.68 (n)
  • 86.13 (a)
(Monodelphis domestica)
Mammalia NARFL 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia NARFL 36
  • 57 (a)
(Gallus gallus)
Aves NARFL 35
  • 70.1 (n)
  • 71.64 (a)
  • 63 (a)
(Anolis carolinensis)
Reptilia NARFL 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia narfl 35
  • 71.64 (n)
  • 71.64 (a)
(Danio rerio)
Actinopterygii narfl 35
  • 65.97 (n)
  • 68.07 (a)
narfl 36
  • 68 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta NARF_ANOGA 35
  • 59.24 (n)
  • 52.46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17683 35
  • 53.78 (n)
  • 49.68 (a)
CG17683 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea oxy-4 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAR1 36
  • 31 (a)
NAR1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16440 35
  • 51.42 (n)
  • 48.8 (a)
(Oryza sativa)
Liliopsida Os03g0748700 35
  • 52.33 (n)
  • 49.34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1190 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for NARFL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARFL Gene

Gene Tree for NARFL (if available)
Gene Tree for NARFL (if available)

Paralogs for NARFL Gene

Paralogs for NARFL Gene

(1) SIMAP similar genes for NARFL Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NARFL: view

Variants for NARFL Gene

Sequence variations from dbSNP and Humsavar for NARFL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8045850 - 739,693(+) GGCCA(C/T)GCCAC reference, missense, utr-variant-5-prime
rs7188554 - 730,517(+) GCCAG(C/T)GTGTG reference, missense
rs13338700 -- 731,292(+) GCCTG(C/T)GCCAG intron-variant
rs61112891 -- 733,156(+) GAGAC(C/G)AAGGT intron-variant
rs9928077 -- 734,765(+) GGCAG(C/T)GCCTG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NARFL Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904707 CNV Loss 21882294
nsv526903 CNV Loss 19592680
dgv2475n71 CNV Loss 21882294
dgv2479n71 CNV Loss 21882294
nsv471063 CNV Loss 18288195
dgv2485n71 CNV Loss 21882294
nsv904759 CNV Loss 21882294
nsv516590 CNV Loss 19592680
dgv2488n71 CNV Loss 21882294
nsv904781 CNV Gain 21882294
nsv471065 CNV Gain 18288195
nsv9321 CNV Gain+Loss 18304495
dgv2491n71 CNV Loss 21882294
nsv904796 CNV Loss 21882294
nsv904797 CNV Loss 21882294
dgv2492n71 CNV Loss 21882294
nsv457311 CNV Loss 19166990
dgv2495n71 CNV Loss 21882294
nsv904812 CNV Loss 21882294
dgv2497n71 CNV Loss 21882294

Variation tolerance for NARFL Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NARFL Gene

Disorders for NARFL Gene

Relevant External Links for NARFL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NARFL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NARFL Gene

Publications for NARFL Gene

  1. IOP1, a novel hydrogenase-like protein that modulates hypoxia- inducible factor-1alpha activity. (PMID: 16956324) Huang J. … Lee F.S. (Biochem. J. 2007) 2 3 4 67
  2. Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis. (PMID: 19864422) Song D. … Lee F.S. (J. Biol. Chem. 2009) 3 23
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for NARFL Gene

Sources for NARFL Gene