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NARFL Gene

protein-coding   GIFtS: 54
GCID: GC16M000796

Nuclear Prelamin A Recognition Factor-Like

  See NARFL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Prelamin A Recognition Factor-Like1 2     PRN2 3
Iron-Only Hydrogenase-Like Protein 11 2 3     HPRN2
IOP12 3 5     LET1L2
Nuclear Prelamin A Recognition Factor-Like Protein2 3     Cytosolic Fe-S Cluster Assembly Factor NARFL2
Protein Related To Narf2 3     LET1 Like/JFP152

External Ids:    HGNC: 141791   Entrez Gene: 644282   Ensembl: ENSG000001032457   OMIM: 6111185   UniProtKB: Q9H6Q43   

Export aliases for NARFL gene to outside databases

Previous GC identifers: GC16U990170 GC16M000720 GC16M000721 GC16M000722 GC16M000781 GC16M000701 GC16M000782 GC16M000783 GC16M000784 GC16M000785 GC16M000787 GC16M000794


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NARFL Gene:
NARFL (nuclear prelamin A recognition factor-like) is a protein-coding gene. Diseases associated with NARFL include pertussis. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding. An important paralog of this gene is NARF.

UniProtKB/Swiss-Prot: NARFL_HUMAN, Q9H6Q4
Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that
mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively
regulate the level of HIF1A expression, although this effect could be indirect




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NARFL gene promoter:
         Max1   p53   XBP-1   E47   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNARFL promoter sequence
   Search Chromatin IP Primers for NARFL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NARFL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NARFL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NARFL gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M000796:  view genomic region     (about GC identifiers)

Start:
779,753 bp from pter      End:
791,329 bp from pter
Size:
11,577 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NARFL_HUMAN, Q9H6Q4 (See protein sequence)
Recommended Name: Cytosolic Fe-S cluster assembly factor NARFL  
Size: 476 amino acids; 53020 Da
Subunit: Component of the CIA complex
Sequence caution: Sequence=AAK61251.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L385 B3KTJ3 Q53GC6 Q96S10 Q9H6J8
Alternative splicing: 3 isoforms:  Q9H6Q4-1   Q9H6Q4-2   Q9H6Q4-3   

Explore the universe of human proteins at neXtProt for NARFL: NX_Q9H6Q4

Explore proteomics data for NARFL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys342, Lys347
  • Modification sites at PhosphoSitePlus

  • See NARFL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071938.1  
    ENSEMBL proteins: 
     ENSP00000251588   ENSP00000457058   ENSP00000444008   ENSP00000456497   ENSP00000456701  
     ENSP00000456733   ENSP00000455543   ENSP00000459523   ENSP00000455514   ENSP00000457609  
     ENSP00000301694  
    Reactome Protein details: Q9H6Q4

    NARFL Human Recombinant Protein Products:

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    Novus Biologicals NARFL Protein
    Novus Biologicals NARFL Lysate
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    Cloud-Clone Corp. Proteins for NARFL

     
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    antibodies-online proteins for NARFL (7 products) 

     
    antibodies-online peptides for NARFL

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    antibodies-online antibodies for NARFL (28 products) 

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    antibodies-online kits for NARFL (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004108 Fe_hydrogenase_lsu_C
     IPR009016 Fe_hydrogenase
     IPR003149 Fe_hydrogenase_ssu-like

    Graphical View of Domain Structure for InterPro Entry Q9H6Q4

    ProtoNet protein and cluster: Q9H6Q4

    1 Blocks protein domain: IPB004108 Hydrogenase large subunit

    UniProtKB/Swiss-Prot: NARFL_HUMAN, Q9H6Q4
    Similarity: Belongs to the NARF family


    Find genes that share domains with NARFL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NARFL_HUMAN, Q9H6Q4
    Function: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that
    mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively
    regulate the level of HIF1A expression, although this effect could be indirect

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--
         
    Find genes that share ontologies with NARFL           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Narfl):
     mortality/aging  normal 

    Find genes that share phenotypes with NARFL           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NARFL
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    Sino Biological Human cDNA Clone for NARFL
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARFL

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0097361CIA complex IDA--

    Find genes that share ontologies with NARFL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NARFL About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    2Cytosolic Iron-sulfur Cluster Assembly
    Cytosolic Iron-sulfur Cluster Assembly


    Find genes that share SuperPaths with NARFL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NARFL
        Cytosolic iron-sulfur cluster assembly


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NARFL
    Interactions:

        GeneGlobe Interaction Network for NARFL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NARFL (Q9H6Q43 ENSP000002515884) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAO1O760713, ENSP000004182874I2D: score=3 STRING: ENSP00000418287
    NUBP1P533843, ENSP000002830274I2D: score=1 STRING: ENSP00000283027
    NUBP2Q9Y5Y23, ENSP000002623024I2D: score=1 STRING: ENSP00000262302
    FAM96BQ9Y3D03, ENSP000003874714I2D: score=2 STRING: ENSP00000387471
    HSPA5P110213I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA16956324
    GO:0006355regulation of transcription, DNA-templated IDA16956324
    GO:0016226iron-sulfur cluster assembly IMP18270200
    GO:0032364oxygen homeostasis IDA16956324
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NARFL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NARFL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NARFL gene: 
    NM_022493.1  

    Unigene Cluster for NARFL:

    Nuclear prelamin A recognition factor-like
    Hs.513247  [show with all ESTs]
    Unigene Representative Sequence: AK056467
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000251588(uc002cjr.3) ENST00000568545(uc002cjp.3) ENST00000566650
    ENST00000540986(uc002cjq.3) ENST00000563051 ENST00000565425(uc021tab.1)
    ENST00000562862 ENST00000564285(uc010uuq.1) ENST00000562421 ENST00000565341(uc010brc.1)
    ENST00000562752(uc010uur.1) ENST00000569759 ENST00000567403 ENST00000563534
    ENST00000565065 ENST00000566614 ENST00000570289 ENST00000570066
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat NARFL

    Additional mRNA sequence: 

    AK025641.1 AK025861.1 AK056467.1 AK094812.1 AK095675.1 AK126151.1 AK223005.1 AK293591.1 
    AK300087.1 AK301023.1 AK310875.1 AY129231.1 BC030248.1 BC129940.1 

    19 DOTS entries:

    DT.99963005  DT.97845252  DT.452434  DT.100652191  DT.101976868  DT.120675917  DT.95166941  DT.100786989 
    DT.100786988  DT.100804026  DT.120675943  DT.100832161  DT.91762176  DT.95166934  DT.100639095  DT.100786994 
    DT.120675945  DT.40284527  DT.86848777 

    Selected AceView cDNA sequences (see all 137):

    AK095675 AA845844 BX346342 AK025641 AA377853 BF431438 BC030248 AW271336 
    BX388203 BX401005 CD722827 BM727891 CR595518 AK025861 AK056467 AY129231 
    AI218505 AW468335 BF000612 AI658913 AA346989 AI084452 NM_022493 AW449760 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NARFL (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
    SP1:                          -     -     -           -     -           -                                                         
    SP2:                                                  -     -           -                       -                                 
    SP3:                          -     -     -     -     -     -           -     -     -                                             
    SP4:                                -     -     -     -     -           -                                                         
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for NARFL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NARFL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAAGACC
    NARFL Expression
    About this image

    NARFL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NARFL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513247

    UniProtKB/Swiss-Prot: NARFL_HUMAN, Q9H6Q4
    Tissue specificity: Widely expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARFL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NARFL gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Narfl1 , 5 nuclear prelamin A recognition factor-like1, 5 83.33(n)1
    87.61(a)1
      17 (12.88 cM)5
    675631  NM_026238.41  NP_080514.31 
     257737765 
    chicken
    (Gallus gallus)
    Aves NARFL1 nuclear prelamin A recognition factor-like 70.1(n)
    71.64(a)
      416535  NM_001277555.1  NP_001264484.1 
    lizard
    (Anolis carolinensis)
    Reptilia NARFL6
    nuclear prelamin A recognition factor-like
    57(a)
    1 ↔ 1
    GL343263.1(1958263-1969860)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia narfl1 nuclear prelamin A recognition factor-like 71.64(n)
    71.64(a)
      100127749  NM_001113086.1  NP_001106557.1 
    zebrafish
    (Danio rerio)
    Actinopterygii narfl1 nuclear prelamin A recognition factor-like 65.97(n)
    68.07(a)
      560541  NM_001080991.2  NP_001074460.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176831 CG17683 53.78(n)
    49.68(a)
      3355011  NM_001042963.2  NP_001036428.1 
    worm
    (Caenorhabditis elegans)
    Secernentea oxy-46
    Protein OXY-4 (oxy-4) mRNA, complete cds
    36(a)
    1 → many
    III(5155461-5158774) WBGene00021902
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAR1(YNL240C)4 Component of the cytosolic iron-sulfur (FeS) protein more   --   14(199977-198502) 855481  NP_014159.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G164401 AT4G16440 51.42(n)
    48.8(a)
      827338  NM_117739.4  NP_567496.4 
    rice
    (Oryza sativa)
    Liliopsida AK067853.12   -- 77.1(n)    AK067853.1 


    ENSEMBL Gene Tree for NARFL (if available)
    TreeFam Gene Tree for NARFL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NARFL gene
    NARF2  
    1 SIMAP similar gene for NARFL using alignment to 8 protein entries:     NARFL_HUMAN (see all proteins):
    NARF

    Find genes that share paralogs with NARFL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NARFL (see all 420)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844739131,2
    --780285(+) TAGTCC/TTAGCT 1 -- ut310--------
    rs1881469691,2
    --780298(+) TACTCA/GGGTCC 1 -- ut310--------
    rs72053371,2
    C,F,A,H--780339(+) GGGGGA/GAGCCC 1 -- ut31 ese320Minor allele frequency- G:0.49NS EA WA NA CSA EU 2705
    rs1175016911,2
    C--780360(+) GGGCAT/CGTGGT 1 -- ut312Minor allele frequency- C:0.00NA EU 1385
    rs2002933621,2
    C,F--780375(+) CTGTCA/GCACAT 1 -- ut311Minor allele frequency- G:0.01EU 1301
    rs2020932291,2
    --780403(+) AGTCCG/TGGTCC 1 -- ut310--------
    rs3687510011,2
    C--780435(+) CCCAGA/GCCAGT 2 G syn10--------
    rs1494033461,2
    C--780455(+) CTCCAA/C/TGGCGT 3 M V L mis11EU 1323
    rs348515151,2
    C,F--780510(-) TGGCTG/ACAGGG 2 /L syn14Minor allele frequency- A:0.02NA CSA WA 4722
    rs71885541,2,,4
    C,F--780517(+) GCCAGT/CGTGTG 2 /H /R mis1 ese37Minor allele frequency- C:0.07NA WA CSA 4722

    HapMap Linkage Disequilibrium report for NARFL (779753 - 791329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NARFL (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2475n71CNV Loss21882294
    nsv904707CNV Loss21882294
    nsv904796CNV Loss21882294
    dgv2492n71CNV Loss21882294
    dgv2497n71CNV Loss21882294
    nsv904797CNV Loss21882294
    dgv2495n71CNV Loss21882294
    nsv904812CNV Loss21882294
    nsv904759CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611118    OMIM disorders: --

    1 disease for NARFL:    
    About MalaCards
    pertussis


    Find genes that share disorders with NARFL           About GenesLikeMe

    Genetic Association Database (GAD): NARFL

    Export disorders for NARFL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NARFL gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NARFL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. IOP1, a novel hydrogenase-like protein that modulates hypoxia- inducible factor-1alpha activity. (PubMed id 16956324)1, 2, 3 Huang J....Lee F.S. (Biochem. J. 2007)
    2. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1, 2 Stehling O.... Lill R. (Science 2012)
    3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1, 4 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    4. A role for IOP1 in mammalian cytosolic iron-sulfur protein biogenesis. (PubMed id 18270200)1, 2 Song D. and Lee F.S. (J. Biol. Chem. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
    7. Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis. (PubMed id 19864422)1, 9 Song D....Lee F.S. (J. Biol. Chem. 2009)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway. (PubMed id 23585563)1 Seki M....Tanaka K. (J. Biol. Chem. 2013)
    10. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. (PubMed id 22678361)2 Gari K....Boulton S.J. (Science 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 64428 HGNC: 14179 AceView: NARFL Ensembl:ENSG00000103245 euGenes: HUgn64428
    ECgene: NARFL H-InvDB: NARFL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NARFL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NARFL gene:
    Search GeneIP for patents involving NARFL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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