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Aliases for NARFL Gene

Aliases for NARFL Gene

  • Nuclear Prelamin A Recognition Factor Like 2 3 5
  • Iron-Only Hydrogenase-Like Protein 1 2 3 4
  • Protein Related To Narf 3 4
  • IOP1 3 4
  • PRN 3 4
  • Nuclear Prelamin A Recognition Factor-Like Protein 4
  • Cytosolic Fe-S Cluster Assembly Factor NARFL 3
  • Nuclear Prelamin A Recognition Factor-Like 2
  • LET1 Like/JFP15 3
  • LET1L 3
  • HPRN 3
  • NAR1 3

External Ids for NARFL Gene

Previous GeneCards Identifiers for NARFL Gene

  • GC16U990170
  • GC16M000720
  • GC16M000721
  • GC16M000722
  • GC16M000781
  • GC16M000701
  • GC16M000782
  • GC16M000783
  • GC16M000784
  • GC16M000785
  • GC16M000787
  • GC16M000794
  • GC16M000796
  • GC16M000808
  • GC16M000826
  • GC16M000847
  • GC16M000862
  • GC16M000878
  • GC16M000897

Summaries for NARFL Gene

GeneCards Summary for NARFL Gene

NARFL (Nuclear Prelamin A Recognition Factor Like) is a Protein Coding gene. Diseases associated with NARFL include Globe Disease and Commensal Bacterial Infectious Disease. Among its related pathways are Cytosolic iron-sulfur cluster assembly and Metabolism. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and NADH dehydrogenase activity. An important paralog of this gene is NARF.

UniProtKB/Swiss-Prot for NARFL Gene

  • Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

Additional gene information for NARFL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARFL Gene

Genomics for NARFL Gene

Regulatory Elements for NARFL Gene

Enhancers for NARFL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H000635 1.4 ENCODE dbSUPER 20 +104.3 104257 4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 METTL26 WDR90 CRAMP1 WFIKKN1 JMJD8 ENSG00000261505 UBE2I TELO2 NARFL ENSG00000226890
GH16H000718 1.3 ENCODE dbSUPER 19.7 +20.6 20566 3 HDGF PKNOX1 SIN3A ZNF2 ZBTB7B ZNF143 ZNF207 DEK SP3 MXD4 CRAMP1 IFT140 LUC7L UBE2I WDR90 TELO2 UNKL WDR24 ENSG00000268836 ENSG00000269482
GH16H000739 1.1 ENCODE 19.7 +0.6 599 1 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 UBE2I ENSG00000261505 WDR90 CRAMP1 UNKL JMJD8 NARFL TELO2 CHTF18 ENSG00000260954
GH16H000713 1.2 ENCODE dbSUPER 16.7 +25.7 25716 3 ARNT ARID4B SIN3A GLIS2 FOS SP3 SP5 MXD4 NFYC RFX3 NARFL ENSG00000262528 FBXL16 RPUSD1 METRN GC16P000968
GH16H000726 1 ENCODE 19.7 +13.5 13507 3 HNRNPUL1 HDGF SIN3A ZNF2 ETS1 GTF3C2 GLIS2 ELK1 ZNF143 SP3 ENSG00000261505 AXIN1 ENSG00000260051 WDR90 TELO2 ENSG00000260954 WASH4P UNKL RHOT2 CRAMP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NARFL on UCSC Golden Path with GeneCards custom track

Promoters for NARFL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082239 429 1401 PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for NARFL Gene

Chromosome:
16
Start:
729,753 bp from pter
End:
741,329 bp from pter
Size:
11,577 bases
Orientation:
Minus strand

Genomic View for NARFL Gene

Genes around NARFL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NARFL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NARFL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARFL Gene

Proteins for NARFL Gene

  • Protein details for NARFL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Q4-NARFL_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NARFL
    Protein Accession:
    Q9H6Q4
    Secondary Accessions:
    • A1L385
    • B3KTJ3
    • Q53GC6
    • Q96S10
    • Q9H6J8

    Protein attributes for NARFL Gene

    Size:
    476 amino acids
    Molecular mass:
    53020 Da
    Quaternary structure:
    • Component of the CIA complex.
    SequenceCaution:
    • Sequence=AAK61251.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NARFL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARFL Gene

Post-translational modifications for NARFL Gene

  • Ubiquitination at Lys342
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NARFL Gene

Domains & Families for NARFL Gene

Gene Families for NARFL Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6Q4

UniProtKB/Swiss-Prot:

NARFL_HUMAN :
  • Belongs to the NARF family.
Family:
  • Belongs to the NARF family.
genes like me logo Genes that share domains with NARFL: view

Function for NARFL Gene

Molecular function for NARFL Gene

UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect.

Phenotypes From GWAS Catalog for NARFL Gene

Gene Ontology (GO) - Molecular Function for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NADH dehydrogenase activity IBA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IBA --
GO:0051539 4 iron, 4 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with NARFL: view

Phenotypes for NARFL Gene

genes like me logo Genes that share phenotypes with NARFL: view

Animal Models for NARFL Gene

MGI Knock Outs for NARFL:

Animal Model Products

  • Taconic Biosciences Mouse Models for NARFL

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NARFL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NARFL Gene

Localization for NARFL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NARFL gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
endosome 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097361 CIA complex IDA 22678361
genes like me logo Genes that share ontologies with NARFL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NARFL Gene

Pathways & Interactions for NARFL Gene

genes like me logo Genes that share pathways with NARFL: view

Pathways by source for NARFL Gene

2 Reactome pathways for NARFL Gene

Gene Ontology (GO) - Biological Process for NARFL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 16956324
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0010468 regulation of gene expression IDA 16956324
GO:0016226 iron-sulfur cluster assembly IMP 18270200
GO:0032364 oxygen homeostasis IDA 16956324
genes like me logo Genes that share ontologies with NARFL: view

No data available for SIGNOR curated interactions for NARFL Gene

Drugs & Compounds for NARFL Gene

No Compound Related Data Available

Transcripts for NARFL Gene

Unigene Clusters for NARFL Gene

Nuclear prelamin A recognition factor-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NARFL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NARFL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - - -
SP5:
SP6: - - - - - -
SP7: - - - - - -
SP8:
SP9:
SP10: -

Relevant External Links for NARFL Gene

GeneLoc Exon Structure for
NARFL
ECgene alternative splicing isoforms for
NARFL

Expression for NARFL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NARFL Gene

Protein differential expression in normal tissues from HIPED for NARFL Gene

This gene is overexpressed in Lymph node (8.9), Retina (7.6), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NARFL Gene



Protein tissue co-expression partners for NARFL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NARFL Gene:

NARFL

SOURCE GeneReport for Unigene cluster for NARFL Gene:

Hs.513247

mRNA Expression by UniProt/SwissProt for NARFL Gene:

Q9H6Q4-NARFL_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for NARFL Gene

  • Nervous system(4.9)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with NARFL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARFL Gene

Orthologs for NARFL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NARFL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARFL 34 33
  • 99.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NARFL 34 33
  • 84.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NARFL 34 33
  • 83.82 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Narfl 33
  • 83.68 (n)
mouse
(Mus musculus)
Mammalia Narfl 16 34 33
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia NARFL 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NARFL 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves NARFL 34 33
  • 70.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARFL 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia narfl 33
  • 71.64 (n)
zebrafish
(Danio rerio)
Actinopterygii narfl 34 33
  • 65.97 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NARF_ANOGA 33
  • 59.24 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17683 33 34
  • 53.78 (n)
worm
(Caenorhabditis elegans)
Secernentea oxy-4 34
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAR1 34 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16440 33
  • 51.42 (n)
rice
(Oryza sativa)
Liliopsida Os03g0748700 33
  • 52.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1190 33
Species where no ortholog for NARFL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARFL Gene

ENSEMBL:
Gene Tree for NARFL (if available)
TreeFam:
Gene Tree for NARFL (if available)

Paralogs for NARFL Gene

Paralogs for NARFL Gene

(1) SIMAP similar genes for NARFL Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NARFL: view

Variants for NARFL Gene

Sequence variations from dbSNP and Humsavar for NARFL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000006549 -- 738,058(+) TAGGC(C/T)TGTGT intron-variant
rs1000147633 -- 738,284(+) GCAGT(-/GGTTCA)TGAGA intron-variant
rs1000322096 -- 734,248(+) AGAAG(C/T)CCTTG reference, missense
rs1000398460 -- 730,102(+) CTTGG(A/G)TGCCC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000441451 -- 738,219(+) CTTCC(A/G)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NARFL Gene

Variant ID Type Subtype PubMed ID
dgv4825n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1160325 CNV duplication 26073780
nsv1160326 CNV duplication 26073780
nsv457311 CNV loss 19166990
nsv471063 CNV loss 18288195
nsv471065 CNV gain 18288195
nsv516590 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv571012 CNV loss 21841781
nsv9321 CNV gain+loss 18304495
nsv952898 CNV deletion 24416366

Variation tolerance for NARFL Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NARFL Gene

Human Gene Mutation Database (HGMD)
NARFL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NARFL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARFL Gene

Disorders for NARFL Gene

MalaCards: The human disease database

(4) MalaCards diseases for NARFL Gene - From: HGMD and DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search NARFL in MalaCards View complete list of genes associated with diseases

Relevant External Links for NARFL

Genetic Association Database (GAD)
NARFL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NARFL
genes like me logo Genes that share disorders with NARFL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NARFL Gene

Publications for NARFL Gene

  1. IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity. (PMID: 16956324) Huang J … Lee FS (The Biochemical journal 2007) 2 3 4 60
  2. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PMID: 22678362) Stehling O … Lill R (Science (New York, N.Y.) 2012) 3 4 60
  3. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. (PMID: 22678361) Gari K … Boulton SJ (Science (New York, N.Y.) 2012) 3 4 60
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 45 60
  5. Human ISCA1 interacts with IOP1/NARFL and functions in both cytosolic and mitochondrial iron-sulfur protein biogenesis. (PMID: 19864422) Song D … Lee FS (The Journal of biological chemistry 2009) 3 22 60

Products for NARFL Gene

Sources for NARFL Gene

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