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Aliases for NARF Gene

Aliases for NARF Gene

  • Nuclear Prelamin A Recognition Factor 2 3
  • Iron-Only Hydrogenase-Like Protein 2 2 3 4
  • IOP2 3 4
  • Prenyl-Dependent Prelamin A Binding Protein 3

External Ids for NARF Gene

Summaries for NARF Gene

Entrez Gene Summary for NARF Gene

  • Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]

GeneCards Summary for NARF Gene

NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. GO annotations related to this gene include lamin binding. An important paralog of this gene is NARFL.

Gene Wiki entry for NARF Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARF Gene

Genomics for NARF Gene

Genomic Location for NARF Gene

Start:
82,458,180 bp from pter
End:
82,490,537 bp from pter
Size:
32,358 bases
Orientation:
Plus strand

Genomic View for NARF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NARF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NARF Gene

Regulatory Elements for NARF Gene

Proteins for NARF Gene

  • Protein details for NARF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHQ1-NARF_HUMAN
    Recommended name:
    Nuclear prelamin A recognition factor
    Protein Accession:
    Q9UHQ1
    Secondary Accessions:
    • A6NCJ3
    • B3KPX2
    • K4DI98
    • Q96AY9
    • Q9BWC6

    Protein attributes for NARF Gene

    Size:
    456 amino acids
    Molecular mass:
    51156 Da
    Quaternary structure:
    • Interacts with LMNA and binds to the farnesylated C-terminal domain.

    Alternative splice isoforms for NARF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NARF Gene

Proteomics data for NARF Gene at MOPED

Post-translational modifications for NARF Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys206, Lys308, Lys326, and Lys394

No data available for DME Specific Peptides for NARF Gene

Domains for NARF Gene

Protein Domains for NARF Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHQ1

UniProtKB/Swiss-Prot:

NARF_HUMAN
Family:
  • Belongs to the NARF family.:
    • Q9UHQ1
genes like me logo Genes that share domains with NARF: view

No data available for Gene Families for NARF Gene

Function for NARF Gene

Gene Ontology (GO) - Molecular Function for NARF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NOT NADH dehydrogenase activity IBA --
GO:0005521 lamin binding IPI 10514485
GO:0051536 NOT iron-sulfur cluster binding IBA --
genes like me logo Genes that share ontologies with NARF: view

Phenotypes for NARF Gene

genes like me logo Genes that share phenotypes with NARF: view

miRNA for NARF Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NARF Gene

Localization for NARF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NARF Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NARF Gene COMPARTMENTS Subcellular localization image for NARF gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Gene Ontology (GO) - Cellular Components for NARF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005638 lamin filament IDA 10514485
GO:0005652 nuclear lamina TAS 10514485
GO:0005730 nucleolus IDA --
GO:0005829 NOT cytosol IBA --
genes like me logo Genes that share ontologies with NARF: view

Pathways for NARF Gene

SuperPathways for NARF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NARF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 NOT iron-sulfur cluster assembly IBA --
genes like me logo Genes that share ontologies with NARF: view

No data available for Pathways by source for NARF Gene

Transcripts for NARF Gene

Unigene Clusters for NARF Gene

Nuclear prelamin A recognition factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NARF Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: -
SP7:
SP8: - - - - - - - -
SP9: - - - - -
SP10: -
SP11: -

Relevant External Links for NARF Gene

GeneLoc Exon Structure for
NARF
ECgene alternative splicing isoforms for
NARF

Expression for NARF Gene

mRNA expression in normal human tissues for NARF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NARF Gene

This gene is overexpressed in Whole Blood (7.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NARF Gene

SOURCE GeneReport for Unigene cluster for NARF Gene Hs.256526

mRNA Expression by UniProt/SwissProt for NARF Gene

Q9UHQ1-NARF_HUMAN
Tissue specificity: Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
genes like me logo Genes that share expressions with NARF: view

Orthologs for NARF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NARF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NARF 35
  • 94.22 (n)
  • 93.11 (a)
NARF 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NARF 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NARF 35
  • 83.92 (n)
  • 84.65 (a)
NARF 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Narf 35
  • 82.97 (n)
  • 85.53 (a)
Narf 16
Narf 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NARF 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NARF 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Narf 35
  • 82.75 (n)
  • 86.4 (a)
chicken
(Gallus gallus)
Aves NARF 35
  • 70.98 (n)
  • 71.27 (a)
NARF 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NARF 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia narf 35
  • 65.27 (n)
  • 61.81 (a)
Str.10161 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3129 35
zebrafish
(Danio rerio)
Actinopterygii narf 35
  • 62.23 (n)
  • 56.88 (a)
narf 36
  • 52 (a)
OneToMany
narf 36
  • 52 (a)
OneToMany
wufa03c01 35
fruit fly
(Drosophila melanogaster)
Insecta CG17683 36
  • 36 (a)
OneToMany
CG17683 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea oxy-4 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAR1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for NARF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NARF Gene

ENSEMBL:
Gene Tree for NARF (if available)
TreeFam:
Gene Tree for NARF (if available)

Paralogs for NARF Gene

Paralogs for NARF Gene

genes like me logo Genes that share paralogs with NARF: view

Variants for NARF Gene

Sequence variations from dbSNP and Humsavar for NARF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs876067 -- 82,465,310(-) TCACC(C/T)Gtgat intron-variant
rs879942 -- 82,480,370(+) CGGCT(A/G)GACTT intron-variant
rs901375 -- 82,480,288(-) gtgtg(C/T)gCGCG intron-variant
rs901376 -- 82,480,188(-) CTGTG(C/G)GTGGG intron-variant
rs1065627 -- 82,458,768(+) CTGAG(G/T)CTGAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NARF Gene

Variant ID Type Subtype PubMed ID
nsv428351 CNV Gain 18775914
dgv3332n71 CNV Loss 21882294
nsv909134 CNV Loss 21882294
esv21913 CNV Gain+Loss 19812545
dgv3353n71 CNV Loss 21882294
dgv3354n71 CNV Loss 21882294
nsv469561 CNV Complex 16826518
nsv909228 CNV Gain 21882294
nsv909229 CNV Loss 21882294
dgv3360n71 CNV Loss 21882294
nsv909231 CNV Loss 21882294
nsv833574 CNV Gain 17160897
dgv3361n71 CNV Loss 21882294
nsv828144 CNV Gain 20364138

Relevant External Links for NARF Gene

HapMap Linkage Disequilibrium report
NARF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARF Gene

Disorders for NARF Gene

(1) University of Copenhagen DISEASES for NARF Gene

Relevant External Links for NARF

Genetic Association Database (GAD)
NARF
Human Genome Epidemiology (HuGE) Navigator
NARF
genes like me logo Genes that share disorders with NARF: view

No data available for UniProtKB/Swiss-Prot for NARF Gene

Publications for NARF Gene

  1. Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PMID: 10514485) Barton R.M. … Worman H.J. (J. Biol. Chem. 1999) 2 3 4 23
  2. RNA-editing-mediated exon evolution. (PMID: 17326827) Lev-Maor G. … Ast G. (Genome Biol. 2007) 3 23
  3. Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PMID: 18680752) Moller-Krull M. … Schmitz J. (J. Mol. Biol. 2008) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PMID: 15667261) Hackstein J.H. (Biochem. Soc. Trans. 2005) 2 3

Products for NARF Gene

Sources for NARF Gene

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