Aliases for NARF Gene
Aliases for NARF Gene
External Ids for NARF Gene
- HGNC: 29916
- Entrez Gene: 26502
- Ensembl: ENSG00000141562
- OMIM: 605349
- UniProtKB: Q9UHQ1
Previous GeneCards Identifiers for NARF Gene
- GC17P079555
- GC17P083333
- GC17P080945
- GC17P081095
- GC17P078009
- GC17P080416
- GC17P075814
Summaries for NARF Gene
-
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
GeneCards Summary for NARF Gene
NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. GO annotations related to this gene include iron-sulfur cluster binding and lamin binding. An important paralog of this gene is NARFL.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARF Gene
Genomics for NARF Gene
Regulatory Elements for NARF Gene
Enhancers for NARF Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NARF on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the NARF gene promoter:
Regulatory Element Products
Genomic Location for NARF Gene
- Chromosome:
- 17
- Start:
- 82,458,180 bp from pter
- End:
- 82,490,537 bp from pter
- Size:
- 32,358 bases
- Orientation:
- Plus strand
Genomic View for NARF Gene
Genes around NARF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC
NARF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NARF Gene
Proteins for NARF Gene
-
Protein details for NARF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHQ1-NARF_HUMAN
- Recommended name:
- Nuclear prelamin A recognition factor
- Protein Accession:
- Q9UHQ1
- A6NCJ3
- B3KPX2
- K4DI98
- Q96AY9
- Q9BWC6
Protein attributes for NARF Gene
- Size:
- 456 amino acids
- Molecular mass:
- 51156 Da
- Quaternary structure:
-
- Interacts with LMNA and binds to the farnesylated C-terminal domain.
Protein Expression for NARF Gene
Post-translational modifications for NARF Gene
Other Protein References for NARF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NARF
- Invitrogen Antibodies for NARF
- antibodies-online Antibodies for NARF: See all 55
- GeneTex NARF antibody for NARF
-
Santa Cruz Biotechnology (SCBT) Antibodies for NARF
Protein Products
-
OriGene Purified Proteins for NARF
- Search Origene for MassSpec and Protein Over-expression Lysates for NARF
- Origene Custom Protein Services for NARF
- Novus Biologicals proteins for NARF
-
Cloud-Clone Corp. Proteins for NARF
- antibodies-online Proteins for NARF: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for NARF
Assay Products
- antibodies-online Kits for NARF: See all 3
No data available for DME Specific Peptides for NARF Gene
Domains & Families for NARF Gene
Protein Domains for NARF Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NARF Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHQ1- Family:
-
- Belongs to the NARF family.
No data available for Gene Families for NARF Gene
Function for NARF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005521 | lamin binding | IPI | 10514485 |
Phenotypes for NARF Gene
- GenomeRNAi human phenotypes for NARF:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for NARF
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NARF gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NARF gene
- Search ViGene Biosciences for NARF
CRISPR Products
-
OriGene CRISPR knockouts for NARF
-
Santa Cruz Biotechnology (SCBT) CRISPR for NARF
- GenScript: Design CRISPR guide RNA sequences for NARF
miRNA for NARF Gene
- miRTarBase miRNAs that target NARF
-
- hsa-mir-98-5p (MIRT027539)
- hsa-mir-24-3p (MIRT030389)
- hsa-mir-16-5p (MIRT031638)
- hsa-mir-423-3p (MIRT042570)
- hsa-mir-6516-5p (MIRT459142)
- hsa-mir-455-3p (MIRT459143)
- hsa-mir-650 (MIRT459144)
- hsa-mir-3612 (MIRT459145)
- hsa-mir-6499-3p (MIRT459146)
- hsa-mir-6086 (MIRT459147)
- hsa-mir-2467-3p (MIRT459148)
- hsa-mir-377-5p (MIRT459149)
- hsa-mir-4487 (MIRT459150)
- hsa-mir-1827 (MIRT459151)
- hsa-mir-558 (MIRT459152)
- hsa-mir-3160-3p (MIRT459153)
- hsa-mir-5186 (MIRT459154)
- hsa-mir-4257 (MIRT459155)
- hsa-mir-1247-3p (MIRT459156)
- hsa-mir-6511a-5p (MIRT459157)
- hsa-mir-1910-3p (MIRT459158)
- hsa-mir-4325 (MIRT701541)
- hsa-mir-7703 (MIRT701542)
- hsa-mir-6720-5p (MIRT701543)
- hsa-mir-6512-3p (MIRT701544)
- hsa-mir-766-3p (MIRT701545)
- hsa-mir-6849-3p (MIRT701546)
- hsa-mir-92b-3p (MIRT701547)
- hsa-mir-92a-3p (MIRT701548)
- hsa-mir-367-3p (MIRT701549)
- hsa-mir-363-3p (MIRT701550)
- hsa-mir-32-5p (MIRT701551)
- hsa-mir-25-3p (MIRT701552)
- hsa-mir-508-5p (MIRT701553)
miRNA Products
- Search ViGene Biosciences for NARF
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NARF
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for NARF
-
ViGene Biosciences adenoviral particle packaged cDNA for NARF gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NARF gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NARF gene
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARF Gene
Localization for NARF Gene
Subcellular locations from UniProtKB/Swiss-Prot for NARF Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| cytosol | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005638 | lamin filament | IDA | 10514485 |
| GO:0005652 | nuclear lamina | TAS | 10514485 |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0031981 | nuclear lumen | IDA | 10514485 |
Pathways & Interactions for NARF Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for NARF Gene
Transcripts for NARF Gene
mRNA/cDNA for NARF Gene
- (11) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (371) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NARF Gene
CRISPR Products
-
OriGene CRISPR knockouts for NARF
-
Santa Cruz Biotechnology (SCBT) CRISPR for NARF
- GenScript: Design CRISPR guide RNA sequences for NARF
miRNA Products
- Search ViGene Biosciences for NARF
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for NARF
- Browse OriGene Inhibitory RNA Products For NARF
-
ViGene Biosciences ready-to-package AAV shRNAs for NARF gene
Clone Products
- Sino Biological Human cDNA Clone for NARF
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NARF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NARF
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - |
Expression for NARF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Liver (Hepatobiliary System)
- Eye (Sensory Organs)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for NARF Gene
This gene is overexpressed in Whole Blood (x7.4).
This gene is overexpressed in Amniocyte (51.7), Bone marrow mesenchymal stem cell (8.7), and Stomach (6.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NARF Gene
NURSA nuclear receptor signaling pathways regulating expression of NARF Gene:
NARFSOURCE GeneReport for Unigene cluster for NARF Gene:
Hs.256526mRNA Expression by UniProt/SwissProt for NARF Gene:
Q9UHQ1-NARF_HUMAN
Tissue specificity:
Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
Evidence on tissue expression from TISSUES for NARF Gene
- Lung(4.6)
- Nervous system(4.5)
- Muscle(4.3)
Primer Products
-
OriGene qPCR primer pairs for NARF
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARF Gene
Orthologs for NARF Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NARF 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | NARF 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NARF 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Narf 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Narf 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NARF 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NARF 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NARF 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NARF 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | narf 34 |
|
||
| Str.10161 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | narf 34 35 35 |
|
||
| wufa03c01 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3129 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG17683 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | oxy-4 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAR1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for NARF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NARF Gene
(9) SIMAP similar genes for NARF Gene using alignment to 16 proteins:
Variants for NARF Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000215800 | -- | 82,463,774(+) | ATAAG(C/T)ATCTT | intron-variant | |
| rs1000270913 | -- | 82,477,144(+) | CTTAG(C/T)CTTCC | intron-variant | |
| rs1000342393 | -- | 82,471,010(+) | ATACA(A/G)AAATT | intron-variant | |
| rs1000375311 | -- | 82,471,314(+) | GCCGG(A/G)CGTGG | intron-variant | |
| rs1000388936 | -- | 82,490,966(+) | CGAGA(G/T)TTCCT | downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv21913 | CNV | gain+loss | 19812545 |
| esv2762577 | CNV | gain+loss | 21179565 |
| esv3641424 | CNV | gain | 21293372 |
| nsv1062980 | CNV | gain | 25217958 |
| nsv1067194 | CNV | gain | 25217958 |
| nsv1160502 | CNV | deletion | 26073780 |
| nsv428351 | CNV | gain | 18775914 |
| nsv469561 | CNV | loss | 16826518 |
| nsv828144 | CNV | gain | 20364138 |
| nsv833574 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.63;
31.34% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NARF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NARF
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARF Gene
Disorders for NARF Gene
Relevant External Links for NARF
No disorders were found for NARF Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NARF Gene
Publications for NARF Gene
- Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PMID: 10514485) Barton R.M. … Worman H.J. (J. Biol. Chem. 1999) 2 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PMID: 18680752) Moller-Krull M. … Schmitz J. (J. Mol. Biol. 2008) 3 22 64
- RNA-editing-mediated exon evolution. (PMID: 17326827) Lev-Maor G. … Ast G. (Genome Biol. 2007) 3 22 64
- Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PMID: 15667261) Hackstein J.H. (Biochem. Soc. Trans. 2005) 2 3 64
Products for NARF Gene
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- OriGene Purified Proteins for NARF
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- GenScript: Design CRISPR guide RNA sequences for NARF
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for NARF
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- Novus Biologicals
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- Cloud-Clone Corp. Proteins for NARF
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- Invitrogen Antibodies for NARF
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- antibodies-online Antibodies for NARF: See all 55
- antibodies-online Kits for NARF: See all 3
- antibodies-online Proteins for NARF: See all 9
- Search antibodies-online for peptides
- GeneTex NARF antibody for NARF
- Search GeneTex for Proteins for NARF
- ViGene Biosciences adenoviral particle packaged cDNA for NARF gene
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- Search ViGene Biosciences for NARF
- Santa Cruz Biotechnology (SCBT) Antibodies for NARF
- Search Santa Cruz Biotechnology (SCBT) for NARF siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NARF
- Horizon Cell Lines for NARF
- Cyagen custom Knockout/knockin (KOKI) mouse models for NARF
- VectorBuilder custom plasmid, inducible vectors for NARF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NARF
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NARF Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
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