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Set Analyses:

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NARF Gene

protein-coding GIFtS: 55
GCID: GC17P080416

Nuclear Prelamin A Recognition Factor

See related disease
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Nuclear Prelamin A Recognition Factor¹ ²
Iron-Only Hydrogenase-Like Protein 2¹ ² ³
IOP2² ³
Prenyl-Dependent Prelamin A Binding Protein²

External Ids:	HGNC: 29916¹	Entrez Gene: 26502²	Ensembl: ENSG00000141562⁷	OMIM: 605349⁵	UniProtKB: Q9UHQ1³

Export aliases for NARF gene to outside databases

Previous GC identifers: GC17P079555 GC17P083333 GC17P080945 GC17P081095 GC17P078009 GC17P075814

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NARF Gene:

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was

initially believed to be important only for membrane attachment. However, another role for prenylation appears to

be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian

cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue

of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A

when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the

prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex.

The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares

limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants

encoding different isoforms have been identified for this gene, including one with a novel exon that is generated

by RNA editing. (provided by RefSeq, Jul 2008)

GeneCards Summary for NARF Gene:

NARF (nuclear prelamin A recognition factor) is a protein-coding gene. Diseases associated with NARF include glaucoma. GO annotations related to this gene include lamin binding. An important paralog of this gene is NARFL.

Gene Wiki entry for NARF Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000017.11 NT_010663.16 NC_018928.2

Regulatory elements:

Regulatory transcription factor binding sites in the NARF gene promoter:
NF-kappaB1 NF-kappaB NF-E2 NF-E2 p45 Roaz
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NARF promoter sequence

Search Chromatin IP Primers for NARF

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NARF

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3

NARF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NARF gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P080416: view genomic region (about GC identifiers)

Start:	80,416,056 bp from pter	End:	80,448,413 bp from pter
Size:	32,358 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1 (See protein sequence)

Recommended Name: Nuclear prelamin A recognition factor

Size: 456 amino acids; 51156 Da

Subunit: Interacts with LMNA and binds to the farnesylated C-terminal domain

Secondary accessions: A6NCJ3 B3KPX2 K4DI98 Q96AY9 Q9BWC6

Alternative splicing: 4 isoforms: Q9UHQ1-1 Q9UHQ1-2 Q9UHQ1-3 Q9UHQ1-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NARF: NX_Q9UHQ1

Explore proteomics data for NARF at MOPED

Post-translational modifications:

Ubiquitination² at Lys206, Lys308, Lys326, Lys394

Modification sites at PhosphoSitePlus

See NARF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001033707.1 NP_001077077.1 NP_036468.1 NP_114174.1

ENSEMBL proteins:

ENSP00000462240 ENSP00000374656 ENSP00000463347 ENSP00000309899 ENSP00000283996

ENSP00000462305 ENSP00000363739 ENSP00000467119 ENSP00000414678 ENSP00000464644

ENSP00000463087 ENSP00000462792 ENSP00000462006 ENSP00000463697 ENSP00000464124

ENSP00000462970 ENSP00000409710

NARF Human Recombinant Protein Products:

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NARF Antibody Products:

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	LSBio Antibodies in human, mouse, rat for NARF

NARF Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for NARF Cloud-Clone Corp. CLIAs for NARF

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:

IPR004108 Fe_hydrogenase_lsu_C

IPR009016 Fe_hydrogenase

IPR003149 Fe_hydrogenase_ssu-like

Graphical View of Domain Structure for InterPro Entry Q9UHQ1

ProtoNet protein and cluster: Q9UHQ1

UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1

Similarity: Belongs to the NARF family

NARF for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005521	lamin binding	IPI	10514485

NARF for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for NARF:

G0/1 arrest

Increased G1 DNA content

Increased cell size

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NARF

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genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NARF

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NARF

miRNA Products:		miRTarBase miRNAs that target NARF: hsa-mir-423-3p (MIRT042570), hsa-mir-16-5p (MIRT031638), hsa-mir-24-3p (MIRT030389), hsa-mir-98-5p (MIRT027539)

		Block miRNA regulation of human, mouse, rat NARF using miScript Target Protectors
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NARF

Clone Products:		OriGene clones in human, mouse for NARF (see all 22) OriGene ORF clones in mouse, rat for NARF OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): NARF (NM_001038618)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARF

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NARF_HUMAN, Q9UHQ1: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5
cytoskeleton	4
cytosol	2

About this image

Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005638	lamin filament	IDA	10514485
GO:0005652	nuclear lamina	TAS	10514485
GO:0031981	nuclear lumen	IDA	10514485

NARF for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NARF
Interactions:

Search GeneGlobe Interaction Network for NARF

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

Selected Interacting proteins for NARF (Q9UHQ1³ ENSP00000309899⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LMNA	P02545³, ENSP00000357283⁴	I2D: score=2 STRING: ENSP00000357283
LMNB1	ENSP00000261366⁴	STRING: ENSP00000261366
PCBP4	ENSP00000378461⁴	STRING: ENSP00000378461
QKI	ENSP00000354951⁴	STRING: ENSP00000354951
TAF9	ENSP00000217893⁴	STRING: ENSP00000217893

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NARF

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NARF gene (4 alternative transcripts):

NM_001038618.2 NM_001083608.1 NM_012336.3 NM_031968.2

Unigene Cluster for NARF:

Nuclear prelamin A recognition factor

Hs.256526 [show with all ESTs]

Unigene Representative Sequence: AK093717

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000579198 ENST00000390006(uc002kff.4) ENST00000583181 ENST00000584192

ENST00000580296 ENST00000309794(uc002kfg.4 uc002kfj.4) ENST00000345415

ENST00000581202(uc010wvo.1) ENST00000374611(uc010dit.3) ENST00000582585

ENST00000457415 ENST00000584411 ENST00000581795 ENST00000577812(uc010wvp.1)

ENST00000581743 ENST00000577432 ENST00000582907 ENST00000578082

miRNA Products:		Block miRNA regulation of human, mouse, rat NARF using miScript Target Protectors
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Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NARF
		Predesigned siRNA for gene silencing in human, mouse, rat NARF

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		GenScript: all cDNA clones in your preferred vector (see all 4): NARF (NM_001038618)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NARF
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Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for NARF
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NARF
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		QuantiFast Probe-based Assays in human, mouse, rat NARF

Additional mRNA sequence:

AF128406.1 AK000929.1 AK056966.1 AK093717.1 AK297875.1 AK303155.1 AK307351.1 AL137729.1

BC000438.2 BC016440.1

Selected DOTS entries (see all 27):

DT.100890151 DT.100890145 DT.100890169 DT.416841 DT.95364511 DT.100890160 DT.100890150 DT.100890164

DT.100890156 DT.91729281 DT.120948878 DT.120948879 DT.100676289 DT.100890170 DT.120948942 DT.95364496

DT.100890147 DT.102832639 DT.120811836 DT.120948901 DT.120948932 DT.40316311 DT.91653691 DT.91871164

Selected AceView cDNA sequences (see all 371):

CR611448 CR595982 BQ052529 BM049683 BE796850 AI591061 CB158088 AI479731

AA632918 AK093717 CR620704 AI140362 BE388297 BI117025 AL137729 AI886089

BI522440 BE349169 BQ006927 BU662997 BQ009205 AI085650 AI338665 BE908281

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for NARF (see all 11) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12	^	13	^	14
SP1:											-				-																-		-								-
SP2:			-		-		-		-		-				-																-		-				-				-
SP3:											-				-																-		-				-				-
SP4:											-				-		-		-												-		-				-				-
SP5:																															-		-				-

ECgene alternative splicing isoforms for NARF

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NARF expression in normal human tissues (normalized intensities) NARF embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CGGATAAGGC

About this image

NARF expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Liver (Hepatobiliary System)
Liver Lobule

Blood (Hematopoietic System)
Proerythroblasts Hematopoietic Bone Marrow

Eye (Sensory Organs)
Retina

Thymus (Hematopoietic System)

NARF Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NARF Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.256526

UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1

Tissue specificity: Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARF

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for NARF gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Narf^{1 , 5}	nuclear prelamin A recognition factor^{1, 5}	82.97(n)¹ 85.53(a)¹		11 (85.12 cM)⁵ 67608¹ NM_026272.3¹ NP_080548.3¹ 121237253⁵
chicken (Gallus gallus)	Aves	NARF¹	nuclear prelamin A recognition factor	70.98(n) 71.27(a)		417341 XM_004946090.1 XP_004946147.1
lizard (Anolis carolinensis)	Reptilia	NARF⁶	nuclear prelamin A recognition factor	64(a)	1 ↔ 1	2(109478731-109507145)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.10161²	Transcribed sequence with weak similarity to protein more	75.44(n)		137715702
zebrafish (Danio rerio)	Actinopterygii	wufa03c01²	wufa03c01	78.49(n)		334768 BQ263356.1
fruit fly (Drosophila melanogaster)	Insecta	CG17683³	--	42(a)		--
worm (Caenorhabditis elegans)	Secernentea	oxy-4⁶	Protein OXY-4 (oxy-4) mRNA, complete cds	30(a)	1 → many	III(5155461-5158774) WBGene00021902
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	NAR1⁶	Component of the cytosolic iron-sulfur (FeS) prote...	24(a)	1 → many	XIV(198502-199977) YNL240C

ENSEMBL Gene Tree for NARF (if available)
TreeFam Gene Tree for NARF (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NARF gene

NARFL²

9 SIMAP similar genes for NARF using alignment to 16 protein entries: NARF_HUMAN (see all proteins):

CCDC180 WDR83 TARDBP NARFL BEST1 TTC8

FLJ10385 SS18 NAG18

NARF for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149830257^1,2	C	--	80414155(+)	`AACCTG/TGAAAC`	1	--	us2k¹		0	--	--	--	--
rs77525698^1,2	F	--	80414172(+)	`GATAAT/CAGTCC`	1	--	us2k¹		1		NA	120
rs147920402^1,2		--	80414199(+)	`CCTCCA/CACTTC`	1	--	us2k¹		0	--	--	--	--
rs111919352^1,2	F	--	80414398(+)	`CCTAAG/CAATGG`	1	--	us2k¹		1		CSA	2
rs145693837^1,2		--	80414506(+)	`GGACCA/GTTTTC`	1	--	us2k¹		0	--	--	--	--
rs147745155^1,2		--	80414734(+)	`CAAAAA/GTTAGC`	4	--	us2k¹		0	--	--	--	--
rs113017047^1,2	C,F	--	80414752(+)	`GGTGGC/TGTGTG`	4	--	us2k¹		1		WA	2
rs4789689^1,2	C	--	80414763(+)	`cctgtA/Cgtccc`	4	--	us2k¹		3		NA CSA	5
rs182280801^1,2		--	80414764(+)	`CTGTCA/GTCCCA`	4	--	us2k¹		0	--	--	--	--
rs187900269^1,2		--	80414888(+)	`CAAAAA/GCAAAA`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NARF (80416056 - 80448413 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for NARF (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
dgv3354n71	CNV	Loss	21882294
dgv3353n71	CNV	Loss	21882294
nsv909134	CNV	Loss	21882294
nsv909229	CNV	Loss	21882294
dgv3360n71	CNV	Loss	21882294
nsv909231	CNV	Loss	21882294
dgv3361n71	CNV	Loss	21882294
dgv3332n71	CNV	Loss	21882294
nsv909228	CNV	Gain	21882294
nsv428351	CNV	Gain	18775914

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NARF

DNA2.0 Custom Variant and Variant Library Synthesis for NARF

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 605349 OMIM disorders: --

1 disease for NARF: About MalaCards

glaucoma

1 disease from the University of Copenhagen DISEASES database for NARF:

Glaucoma

NARF for disorders About GeneDecksing

Genetic Association Database (GAD): NARF
Human Genome Epidemiology (HuGE) Navigator: NARF (2 documents)

Export disorders for NARF gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NARF gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with NARF)

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Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PubMed id 10514485)^{1, 2, 3, 9} Barton R.M. and Worman H.J. (J. Biol. Chem. 1999)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PubMed id 15667261)^{1, 3} Hackstein J.H. (Biochem. Soc. Trans. 2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PubMed id 18680752)^{1, 9} Moller-Krull M.... Schmitz J. (J. Mol. Biol. 2008)
RNA-editing-mediated exon evolution. (PubMed id 17326827)^{1, 9} Lev-Maor G....Ast G. (Genome Biol. 2007)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)¹ Stehling O.... Lill R. (Science 2012)
Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (Mol. Cell 2011)
Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants. (PubMed id 20970119)¹ Malki K....Schalkwyk L.C. (Biol. Psychiatry 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 26502	HGNC: 29916	AceView: NARF	Ensembl:ENSG00000141562	euGenes: HUgn26502
ECgene: NARF	H-InvDB: NARF

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NARF	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NARF gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NARF gene:
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Nuclear Prelamin A Recognition Factor

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Nuclear Prelamin A Recognition Factor

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