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NARF Gene

protein-coding   GIFtS: 55
GCID: GC17P080416

Nuclear Prelamin A Recognition Factor

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nuclear Prelamin A Recognition Factor1 2
Iron-Only Hydrogenase-Like Protein 21 2 3
IOP22 3
Prenyl-Dependent Prelamin A Binding Protein2

External Ids:    HGNC: 299161   Entrez Gene: 265022   Ensembl: ENSG000001415627   OMIM: 6053495   UniProtKB: Q9UHQ13   

Export aliases for NARF gene to outside databases

Previous GC identifers: GC17P079555 GC17P083333 GC17P080945 GC17P081095 GC17P078009 GC17P075814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NARF Gene:
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was
initially believed to be important only for membrane attachment. However, another role for prenylation appears to
be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian
cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue
of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A
when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the
prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex.
The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares
limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants
encoding different isoforms have been identified for this gene, including one with a novel exon that is generated
by RNA editing. (provided by RefSeq, Jul 2008)

GeneCards Summary for NARF Gene:
NARF (nuclear prelamin A recognition factor) is a protein-coding gene. Diseases associated with NARF include glaucoma. GO annotations related to this gene include lamin binding. An important paralog of this gene is NARFL.

Gene Wiki entry for NARF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010663.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NARF gene promoter:
         NF-kappaB1   NF-kappaB   NF-E2   NF-E2 p45   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNARF promoter sequence
   Search Chromatin IP Primers for NARF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NARF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

NARF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NARF gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P080416:  view genomic region     (about GC identifiers)

Start:
80,416,056 bp from pter      End:
80,448,413 bp from pter
Size:
32,358 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1 (See protein sequence)
Recommended Name: Nuclear prelamin A recognition factor  
Size: 456 amino acids; 51156 Da
Subunit: Interacts with LMNA and binds to the farnesylated C-terminal domain
Secondary accessions: A6NCJ3 B3KPX2 K4DI98 Q96AY9 Q9BWC6
Alternative splicing: 4 isoforms:  Q9UHQ1-1   Q9UHQ1-2   Q9UHQ1-3   Q9UHQ1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NARF: NX_Q9UHQ1

Explore proteomics data for NARF at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys206, Lys308, Lys326, Lys394
  • Modification sites at PhosphoSitePlus

  • See NARF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001033707.1  NP_001077077.1  NP_036468.1  NP_114174.1  

    ENSEMBL proteins: 
     ENSP00000462240   ENSP00000374656   ENSP00000463347   ENSP00000309899   ENSP00000283996  
     ENSP00000462305   ENSP00000363739   ENSP00000467119   ENSP00000414678   ENSP00000464644  
     ENSP00000463087   ENSP00000462792   ENSP00000462006   ENSP00000463697   ENSP00000464124  
     ENSP00000462970   ENSP00000409710  

    NARF Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004108 Fe_hydrogenase_lsu_C
     IPR009016 Fe_hydrogenase
     IPR003149 Fe_hydrogenase_ssu-like

    Graphical View of Domain Structure for InterPro Entry Q9UHQ1

    ProtoNet protein and cluster: Q9UHQ1

    UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1
    Similarity: Belongs to the NARF family


    NARF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005521lamin binding IPI10514485
         
    NARF for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NARF:
     G0/1 arrest  Increased G1 DNA content  Increased cell size  Increased gamma-H2AX phosphory 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NARF

    miRNA
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    miRTarBase miRNAs that target NARF:
    hsa-mir-423-3p (MIRT042570), hsa-mir-16-5p (MIRT031638), hsa-mir-24-3p (MIRT030389), hsa-mir-98-5p (MIRT027539)

    Block miRNA regulation of human, mouse, rat NARF using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat NARF

    Gene Editing
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    OriGene ORF clones in mouse, rat for NARF
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    GenScript: all cDNA clones in your preferred vector (see all 4): NARF (NM_001038618)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NARF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARF

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NARF_HUMAN, Q9UHQ1: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005638lamin filament IDA10514485
    GO:0005652nuclear lamina TAS10514485
    GO:0031981nuclear lumen IDA10514485

    NARF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NARF
    Interactions:

        Search GeneGlobe Interaction Network for NARF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for NARF (Q9UHQ13 ENSP000003098994) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMNAP025453, ENSP000003572834I2D: score=2 STRING: ENSP00000357283
    LMNB1ENSP000002613664STRING: ENSP00000261366
    PCBP4ENSP000003784614STRING: ENSP00000378461
    QKIENSP000003549514STRING: ENSP00000354951
    TAF9ENSP000002178934STRING: ENSP00000217893
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NARF



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NARF gene (4 alternative transcripts): 
    NM_001038618.2  NM_001083608.1  NM_012336.3  NM_031968.2  

    Unigene Cluster for NARF:

    Nuclear prelamin A recognition factor
    Hs.256526  [show with all ESTs]
    Unigene Representative Sequence: AK093717
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000579198 ENST00000390006(uc002kff.4) ENST00000583181 ENST00000584192
    ENST00000580296 ENST00000309794(uc002kfg.4 uc002kfj.4) ENST00000345415
    ENST00000581202(uc010wvo.1) ENST00000374611(uc010dit.3) ENST00000582585
    ENST00000457415 ENST00000584411 ENST00000581795 ENST00000577812(uc010wvp.1)
    ENST00000581743 ENST00000577432 ENST00000582907 ENST00000578082
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NARF
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    OriGene ORF clones in mouse, rat for NARF
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    GenScript: all cDNA clones in your preferred vector (see all 4): NARF (NM_001038618)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NARF
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NARF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NARF
      QuantiTect SYBR Green Assays in human, mouse, rat NARF
      QuantiFast Probe-based Assays in human, mouse, rat NARF

    Additional mRNA sequence: 

    AF128406.1 AK000929.1 AK056966.1 AK093717.1 AK297875.1 AK303155.1 AK307351.1 AL137729.1 
    BC000438.2 BC016440.1 

    Selected DOTS entries (see all 27):

    DT.100890151  DT.100890145  DT.100890169  DT.416841  DT.95364511  DT.100890160  DT.100890150  DT.100890164 
    DT.100890156  DT.91729281  DT.120948878  DT.120948879  DT.100676289  DT.100890170  DT.120948942  DT.95364496 
    DT.100890147  DT.102832639  DT.120811836  DT.120948901  DT.120948932  DT.40316311  DT.91653691  DT.91871164 

    Selected AceView cDNA sequences (see all 371):

    CR611448 CR595982 BQ052529 BM049683 BE796850 AI591061 CB158088 AI479731 
    AA632918 AK093717 CR620704 AI140362 BE388297 BI117025 AL137729 AI886089 
    BI522440 BE349169 BQ006927 BU662997 BQ009205 AI085650 AI338665 BE908281 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NARF (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                                -           -                                               -     -                       -                     
    SP2:        -     -     -     -     -           -                                               -     -           -           -                     
    SP3:                                -           -                                               -     -           -           -                     
    SP4:                                -           -     -     -                                   -     -           -           -                     
    SP5:                                                                                            -     -           -                                 


    ECgene alternative splicing isoforms for NARF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NARF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGATAAGGC
    NARF Expression
    About this image


    NARF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
     
     Thymus (Hematopoietic System)
    NARF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NARF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256526

    UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1
    Tissue specificity: Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NARF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NARF gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Narf1 , 5 nuclear prelamin A recognition factor1, 5 82.97(n)1
    85.53(a)1
      11 (85.12 cM)5
    676081  NM_026272.31  NP_080548.31 
     1212372535 
    chicken
    (Gallus gallus)
    Aves NARF1 nuclear prelamin A recognition factor 70.98(n)
    71.27(a)
      417341  XM_004946090.1  XP_004946147.1 
    lizard
    (Anolis carolinensis)
    Reptilia NARF6
    nuclear prelamin A recognition factor
    64(a)
    1 ↔ 1
    2(109478731-109507145)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.101612 Transcribed sequence with weak similarity to protein more 75.44(n)    137715702 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa03c012 wufa03c01 78.49(n)   334768  BQ263356.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG176833   -- 42(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea oxy-46
    Protein OXY-4 (oxy-4) mRNA, complete cds
    30(a)
    1 → many
    III(5155461-5158774) WBGene00021902
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NAR16
    Component of the cytosolic iron-sulfur (FeS) prote...
    24(a)
    1 → many
    XIV(198502-199977) YNL240C


    ENSEMBL Gene Tree for NARF (if available)
    TreeFam Gene Tree for NARF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NARF gene
    NARFL2  
    9 SIMAP similar genes for NARF using alignment to 16 protein entries:     NARF_HUMAN (see all proteins):
    CCDC180    WDR83    TARDBP    NARFL    BEST1    TTC8
    FLJ10385    SS18    NAG18

    NARF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NARF (see all 831)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1498302571,2
    C--80414155(+) AACCTG/TGAAAC 1 -- us2k10--------
    rs775256981,2
    F--80414172(+) GATAAT/CAGTCC 1 -- us2k11Minor allele frequency- C:0.01NA 120
    rs1479204021,2
    --80414199(+) CCTCCA/CACTTC 1 -- us2k10--------
    rs1119193521,2
    F--80414398(+) CCTAAG/CAATGG 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs1456938371,2
    --80414506(+) GGACCA/GTTTTC 1 -- us2k10--------
    rs1477451551,2
    --80414734(+) CAAAAA/GTTAGC 4 -- us2k10--------
    rs1130170471,2
    C,F--80414752(+) GGTGGC/TGTGTG 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs47896891,2
    C--80414763(+) cctgtA/Cgtccc 4 -- us2k13Minor allele frequency- C:0.00NA CSA 5
    rs1822808011,2
    --80414764(+) CTGTCA/GTCCCA 4 -- us2k10--------
    rs1879002691,2
    --80414888(+) CAAAAA/GCAAAA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for NARF (80416056 - 80448413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NARF (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3354n71CNV Loss21882294
    dgv3353n71CNV Loss21882294
    nsv909134CNV Loss21882294
    nsv909229CNV Loss21882294
    dgv3360n71CNV Loss21882294
    nsv909231CNV Loss21882294
    dgv3361n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    nsv909228CNV Gain21882294
    nsv428351CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605349    OMIM disorders: --

    1 disease for NARF:    
    About MalaCards
    glaucoma

    1 disease from the University of Copenhagen DISEASES database for NARF:
    Glaucoma

    NARF for disorders           About GeneDecksing

    Genetic Association Database (GAD): NARF
    Human Genome Epidemiology (HuGE) Navigator: NARF (2 documents)

    Export disorders for NARF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NARF gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with NARF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PubMed id 10514485)1, 2, 3, 9 Barton R.M. and Worman H.J. (J. Biol. Chem. 1999)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PubMed id 15667261)1, 3 Hackstein J.H. (Biochem. Soc. Trans. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PubMed id 18680752)1, 9 Moller-Krull M.... Schmitz J. (J. Mol. Biol. 2008)
    6. RNA-editing-mediated exon evolution. (PubMed id 17326827)1, 9 Lev-Maor G....Ast G. (Genome Biol. 2007)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity. (PubMed id 22678362)1 Stehling O.... Lill R. (Science 2012)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants. (PubMed id 20970119)1 Malki K....Schalkwyk L.C. (Biol. Psychiatry 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26502 HGNC: 29916 AceView: NARF Ensembl:ENSG00000141562 euGenes: HUgn26502
    ECgene: NARF H-InvDB: NARF

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NARF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NARF gene:
    Search GeneIP for patents involving NARF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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