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Aliases & Descriptions for NARF
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp434G0420 1 , 2 FLJ10067 1 , 2 IOP2 1 , 2 , 3
Descriptions Iron-only hydrogenase-like protein 2 3 nuclear prelamin A recognition factor 2 prenyl-dependent prelamin A binding protein 2
Search outside databases for aliases for NARF genePrevious GC identifers: GC17P079555 GC17P083333 GC17P080945 GC17P081095
Summaries for NARF (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for NARF : Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends.Prenylation was initially believed to be important only for membrane attachment. However, anotherrole for prenylation appears to be its importance in protein-protein interactions. The onlynuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminalCaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when itis endoproteolytically processed into mature lamin A. The protein encoded by this gene binds tothe prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin Aendoprotease complex. The encoded protein is located in the nucleus, where it partiallycolocalizes with the nuclear lamina. It shares limited sequence similarity with iron-onlybacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms havebeen identified for this gene, including one with a novel exon that is generated by RNA editing.[provided by RefSeq] Gene Wiki entry for NARF
Genomic Location for NARF
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the NARF gene Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3 NARF Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P078009:
(about GC identifiers )
Start:
78,009,349 bp from pter
End:
78,039,432 bp from pter
Size:
30,084 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000017.9 NT_010663.14 Proteins for NARF
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1 (See
protein sequence )Recommended Name: Nuclear prelamin A recognition factor Size : 456 amino acids; 51156 Da
Subunit : Interacts with LMNA and binds to the farnesylated C-terminal domain
Subcellular location : Nucleus
Secondary accessions : A6NCJ3 Q96AY9 Q9BWC6Alternative splicing : 3 isoforms : Q9UHQ1-1 Q9UHQ1-2 Q9UHQ1-3
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (4 alternative transcripts):
NP_001033707.1 NP_001077077.1 NP_036468.1 NP_114174.1 ENSEMBL proteins: ENSP00000309899 ENSP00000363739 ENSP00000283996 ENSP00000374656 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for NARF: Assays for NARF:
Protein
Domains/ Families for NARF(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UHQ1 ProtoNet protein and cluster: Q9UHQ1
UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1 Similarity : Belongs to the NARF family
Gene Function for NARF
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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OriGene , and/or
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Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_012336 Applied Biosystems Silencer ® siRNAs for NARF Sigma-Aldrich siRNA for NARF Sigma-Aldrich shRNA for NARF Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001038618                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001038618                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001038618  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_031968 1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for NARF
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for NARF (ENSP00000363739 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for NARF (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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Browse Tocris compounds for NARF
Transcripts for NARF(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_012336 Sigma-Aldrich siRNA for NARF Sigma-Aldrich shRNA for NARF Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001038618 NM_001083608 NM_012336 NM_031968
REFSEQ mRNAs for NARF gene (4 alternative transcripts): NM_001038618.2 NM_001083608.1 NM_012336.3 NM_031968.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001038618 NM_001083608 NM_012336 NM_031968
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_001038618                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_001038618                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001038618  
Additional cDNA sequence: AF128406.1 AK000929.1 AK056966.1 AK093717.1 AK297875.1 AK303155.1 AK307351.1 AL137729.1 BC000438.2 BC016440.1 CR590238.1 CR595670.1 CR595982.1 CR597828.1 CR598397.1 CR601772.1 CR603660.1 CR603694.1 CR606462.1 CR611448.1 CR612983.1 CR619657.1 CR620704.1
24/27 DOTS entries (see all 27
): DT.100890151 DT.100890145 DT.100890169 DT.416841 DT.95364511 DT.100890160 DT.100890150 DT.100890164 DT.100890156 DT.91729281 DT.120948879 DT.120948878 DT.100676289 DT.100890170 DT.120948942 DT.40269535 DT.40316311 DT.95364496 DT.100890147 DT.102832639 DT.120811836 DT.120948901 DT.120948932 DT.91653691
24/371 AceView cDNA sequences (see all 371
):BQ574644 CR611448 BQ649482 AI338665 BI906906 CR595670 CR603694 BM977606 AI886089 BU734059 CB131418 BU656272 AW969088 AL534171 BQ951167 CR598397 AI085650 BI770351 BX442215 AU280807 BG389476 BG397223 BE349169 BM796251
highest scoring ESTs for NARF :AI963118 AA487570 AA488695 AA504341 AA515401 AA554784 AA568721 AA584420 AA602553 AA603444
Unigene Cluster for NARF: Nuclear prelamin A recognition factor Hs.256526 [show with all ESTs ] Unigene Representative Sequence: CR620704 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NARF (see all 11
) ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 SP1 :           -     -                 -   -         -         SP2 :   -   -   -   -   -     -                 -   -     -     -         SP3 :           -     -                 -   -     -     -         SP4 :           -     -   -   -             -   -     -     -         SP5 :                               -   -     -            
About this scheme ECgene alternative splicing isoforms for NARF 4 Ensembl transcripts including schematic representations : ENST00000309794
ENST00000374611
ENST00000345415
ENST00000390006
Expression for NARF
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NARF expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NARF 1 / 2 / 3
4 probe-sets matching NARF gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGCTGACTAASOURCE GeneReport for Unigene cluster: Hs.256526 UniProtKB/Swiss-Prot: NARF_HUMAN, Q9UHQ1 Tissue specificity : Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain
Orthologs for NARF
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NARF gene from 5/10 species (see all 10
)
About this table Species with no ortholog for NARF ENSEMBL Gene Tree for NARF Paralogs for NARF (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for NARF gene NARFL 2
SNPs/Variants for NARF (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NARF (up to first 250kb)
Disorders & Mutations for NARF
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605349
Medical News for NARF (Possibly Related Articles in
Doctor's Guide )
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--
Publications for NARF (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/13 PubMed articles for NARF gene (see all 13
): Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PubMed id 10514485) 1, 2, 3, 4 Barton R.M. and Worman H.J. (1999) Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PubMed id 15667261) 2, 3 Hackstein J.H. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PubMed id 18680752) 1, 3 Moller-Krull M....Schmitz J. (2008) RNA-editing-mediated exon evolution. (PubMed id 17326827) 1, 3 Lev-Maor G....Ast G. (2007) Pre-Lamin A processing is linked to heterochromatin organization. (PubMed id 17654502) 3 Lattanzi G....Capanni C. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332) 4 Matsuoka S.... Elledge S.J. (2007) NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285) 3 Yamada M.... Shibuya H. (2006) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196) 4 Zody M.C.... Nusbaum C. (2006)
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Genome Databases showing NARF
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing NARF
(According to HUGE )
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Specialized Databases showing NARF (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for NARF (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for NARF:
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