Aliases for NARF Gene
Aliases for NARF Gene
External Ids for NARF Gene
- HGNC: 29916
- Entrez Gene: 26502
- Ensembl: ENSG00000141562
- OMIM: 605349
- UniProtKB: Q9UHQ1
Previous GeneCards Identifiers for NARF Gene
- GC17P079555
- GC17P083333
- GC17P080945
- GC17P081095
- GC17P078009
- GC17P080416
- GC17P075814
Summaries for NARF Gene
-
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
GeneCards Summary for NARF Gene
NARF (Nuclear Prelamin A Recognition Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron-sulfur cluster binding and lamin binding. An important paralog of this gene is NARFL.
Additional gene information for NARF Gene
- Monarch Initiative
- Search for NARF at DataMed
- Search for NARF at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NARF Gene
Genomics for NARF Gene
GeneHancer (GH) Regulatory Elements for NARF Gene
- Top Transcription factor binding sites by QIAGEN in the NARF gene promoter:
Regulatory Element Products
Genomic Locations for NARF Gene
- chr17:82,458,180-82,490,537
- (GRCh38/hg38)
- Size:
- 32,358 bases
- Orientation:
- Plus strand
- chr17:80,416,056-80,448,413
- (GRCh37/hg19)
Genomic View for NARF Gene
- Cytogenetic band:
-
- 17q25.3 by Ensembl
- 17q25.3 by Entrez Gene
- 17q25.3 by HGNC


RefSeq DNA sequence for NARF Gene
Proteins for NARF Gene
-
Protein details for NARF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHQ1-NARF_HUMAN
- Recommended name:
- Nuclear prelamin A recognition factor
- Protein Accession:
- Q9UHQ1
- A6NCJ3
- B3KPX2
- K4DI98
- Q96AY9
- Q9BWC6
Protein attributes for NARF Gene
- Size:
- 456 amino acids
- Molecular mass:
- 51156 Da
- Quaternary structure:
-
- Interacts with LMNA and binds to the farnesylated C-terminal domain.
Protein Expression for NARF Gene
Post-translational modifications for NARF Gene
- Ubiquitination at isoforms=2, 3, 4206, Lys308, and isoforms=2, 3, 4394
Other Protein References for NARF Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NARF
-
Abcam antibodies for NARF
- Invitrogen Antibodies for NARF
- GeneTex NARF antibody for NARF
-
Santa Cruz Biotechnology (SCBT) Antibodies for NARF
Protein Products
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OriGene Purified Proteins for NARF
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- Novus Biologicals proteins for NARF
-
Cloud-Clone Corp. Proteins for NARF
- antibodies-online: Search results for 8 available NARF Proteins ranked by validation data
- Compare Top NARF Proteins
-
Quality Products:
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Assay Products
- antibodies-online: Search results for 3 available NARF Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for NARF Gene
Domains & Families for NARF Gene
Gene Families for NARF Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for NARF Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for NARF Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHQ1- Family:
-
- Belongs to the NARF family.
Function for NARF Gene
Phenotypes From GWAS Catalog for NARF Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003954 | NADH dehydrogenase activity | IBA | -- |
GO:0005521 | lamin binding | IPI | 10514485 |
GO:0051536 | NOT iron-sulfur cluster binding | IBA | -- |
Phenotypes for NARF Gene
- GenomeRNAi human phenotypes for NARF:
Animal Model Products
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-
-
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-
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CRISPR Products
-
OriGene CRISPR knockouts for NARF
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- Overview of 129 available NARF gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NARF
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miRNA for NARF Gene
- miRTarBase miRNAs that target NARF
-
- hsa-mir-98-5p (MIRT027539)
- hsa-mir-24-3p (MIRT030389)
- hsa-mir-16-5p (MIRT031638)
- hsa-mir-423-3p (MIRT042570)
- hsa-mir-6516-5p (MIRT459142)
- hsa-mir-455-3p (MIRT459143)
- hsa-mir-650 (MIRT459144)
- hsa-mir-3612 (MIRT459145)
- hsa-mir-6499-3p (MIRT459146)
- hsa-mir-6086 (MIRT459147)
- hsa-mir-2467-3p (MIRT459148)
- hsa-mir-377-5p (MIRT459149)
- hsa-mir-4487 (MIRT459150)
- hsa-mir-1827 (MIRT459151)
- hsa-mir-558 (MIRT459152)
- hsa-mir-3160-3p (MIRT459153)
- hsa-mir-5186 (MIRT459154)
- hsa-mir-4257 (MIRT459155)
- hsa-mir-1247-3p (MIRT459156)
- hsa-mir-6511a-5p (MIRT459157)
- hsa-mir-1910-3p (MIRT459158)
- hsa-mir-4325 (MIRT701541)
- hsa-mir-7703 (MIRT701542)
- hsa-mir-6720-5p (MIRT701543)
- hsa-mir-6512-3p (MIRT701544)
- hsa-mir-766-3p (MIRT701545)
- hsa-mir-6849-3p (MIRT701546)
- hsa-mir-92b-3p (MIRT701547)
- hsa-mir-92a-3p (MIRT701548)
- hsa-mir-367-3p (MIRT701549)
- hsa-mir-363-3p (MIRT701550)
- hsa-mir-32-5p (MIRT701551)
- hsa-mir-25-3p (MIRT701552)
- hsa-mir-508-5p (MIRT701553)
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NARF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for NARF
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NARF Gene
Localization for NARF Gene
Subcellular locations from UniProtKB/Swiss-Prot for NARF Gene
- Nucleus.
- Nucleus (3)
- Nucleoli (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | -- |
GO:0005638 | lamin filament | IDA | 10514485 |
GO:0005652 | nuclear lamina | TAS | 10514485 |
GO:0005730 | nucleolus | IDA | -- |
GO:0031981 | nuclear lumen | IDA | 10514485 |
Pathways & Interactions for NARF Gene
Interacting Proteins for NARF Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NARF Gene
Transcripts for NARF Gene
mRNA/cDNA for NARF Gene
- (11) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (371) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NARF Gene
CRISPR Products
-
OriGene CRISPR knockouts for NARF
- genomics-online: gRNA clones - Search results for 129 available NARF gene related products
- Overview of 129 available NARF gene related products
- Applied Biological Materials CRISPR for NARF
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NARF
- GenScript: Design CRISPR guide RNA sequences for NARF
miRNA Products
- Search ViGene Biosciences for NARF
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for NARF
- Browse OriGene Inhibitory RNA Products For NARF
- genomics-online: shRNA clones - Search results for 129 available NARF gene related products
- Overview of 129 available NARF gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NARF gene
Clone Products
- Sino Biological Human cDNA Clone for NARF
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- VectorBuilder custom plasmid, inducible vectors for NARF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NARF
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NARF
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - |
Expression for NARF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
- Liver (Hepatobiliary System)
- Eye (Sensory Organs)
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for NARF Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NARF Gene
NURSA nuclear receptor signaling pathways regulating expression of NARF Gene:
NARFSOURCE GeneReport for Unigene cluster for NARF Gene:
Hs.256526mRNA Expression by UniProt/SwissProt for NARF Gene:
Q9UHQ1-NARF_HUMANEvidence on tissue expression from TISSUES for NARF Gene
- Lung(4.6)
- Nervous system(4.5)
- Muscle(4.3)
Primer Products
-
OriGene qPCR primer pairs for NARF
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NARF Gene
Orthologs for NARF Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NARF 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | NARF 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | NARF 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Narf 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Narf 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | NARF 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | NARF 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NARF 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | NARF 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | narf 33 |
|
||
Str.10161 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | narf 33 34 34 |
|
||
wufa03c01 33 |
|
||||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3129 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG17683 35 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | oxy-4 34 |
|
OneToMany | |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NAR1 34 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for NARF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NARF Gene
(9) SIMAP similar genes for NARF Gene using alignment to 16 proteins:
Variants for NARF Gene
SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000215800 | -- | 82,463,774(+) | C/T | intron_variant | |
rs1000270913 | -- | 82,477,144(+) | C/T | intron_variant | |
rs1000342393 | -- | 82,471,010(+) | A/G | intron_variant | |
rs1000375311 | -- | 82,471,314(+) | G/A | intron_variant | |
rs1000388936 | -- | 82,490,966(+) | T/G | downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv21913 | CNV | gain+loss | 19812545 |
esv2762577 | CNV | gain+loss | 21179565 |
esv3641424 | CNV | gain | 21293372 |
nsv1062980 | CNV | gain | 25217958 |
nsv1067194 | CNV | gain | 25217958 |
nsv1160502 | CNV | deletion | 26073780 |
nsv428351 | CNV | gain | 18775914 |
nsv469561 | CNV | loss | 16826518 |
nsv828144 | CNV | gain | 20364138 |
nsv833574 | CNV | gain | 17160897 |
Additional Variant Information for NARF Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NARF
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NARF Gene
Disorders for NARF Gene
Additional Disease Information for NARF
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NARF Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NARF Gene
Publications for NARF Gene
- Prenylated prelamin A interacts with Narf, a novel nuclear protein. (PMID: 10514485) Barton RM … Worman HJ (The Journal of biological chemistry 1999) 2 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Beyond DNA: RNA editing and steps toward Alu exonization in primates. (PMID: 18680752) Möller-Krull M … Schmitz J (Journal of molecular biology 2008) 3 22 58
- RNA-editing-mediated exon evolution. (PMID: 17326827) Lev-Maor G … Ast G (Genome biology 2007) 3 22 58
- Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions? (PMID: 15667261) Hackstein JH (Biochemical Society transactions 2005) 2 3 58
Products for NARF Gene
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- Invitrogen Antibodies for NARF
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- VectorBuilder custom plasmid, inducible vectors for NARF
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NARF
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 59 available NARF Antibodies ranked by validation data
- Compare Top NARF Antibodies
- antibodies-online: Search results for 3 available NARF Elisa Kits ranked by validation data
- Compare Top NARF Elisa Kits
- Quality Products:
- antibodies-online: Search results for 8 available NARF Proteins ranked by validation data
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- Quality Products:
- GeneTex NARF antibody for NARF
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- genomics-online: cdna clones - Search results for 129 available NARF gene related products
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- Overview of 129 available NARF gene related products
- genomics-online: gRNA clones - Search results for 129 available NARF gene related products
- Overview of 129 available NARF gene related products
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- Overview of 129 available NARF gene related products
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- Overview of 129 available NARF gene related products
Sources for NARF Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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