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Aliases for NAPSB Gene

Aliases for NAPSB Gene

  • Napsin B Aspartic Peptidase, Pseudogene 2 3 5
  • Napsin A Aspartic Peptidase Pseudogene 3
  • Napsin B Pseudogene 3
  • Napsin-A Pseudogene 3
  • Pronapsin B 3
  • Napsin 2 3
  • NAPSBP 3
  • NAP1L 3
  • NAP2 3
  • NAPB 3

External Ids for NAPSB Gene

Previous GeneCards Identifiers for NAPSB Gene

  • GC19M055530
  • GC19M055531
  • GC19M050837
  • GC19M047175

Summaries for NAPSB Gene

GeneCards Summary for NAPSB Gene

NAPSB (Napsin B Aspartic Peptidase, Pseudogene) is a Pseudogene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSB Gene

Genomics for NAPSB Gene

Regulatory Elements for NAPSB Gene

Enhancers for NAPSB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F050340 1.2 Ensembl ENCODE 76.1 +1.9 1871 5.8 HDGF TBP PKNOX1 TBL1XR1 CREB3L1 BMI1 ZBTB40 ZEB1 ZNF121 CBX5 NAPSB KCNC3
GH19F050346 1.2 Ensembl ENCODE 71.9 -3.3 -3272 3.9 ELF3 PKNOX1 ATF1 TBL1XR1 ARID4B BMI1 DMAP1 ZNF48 RARA ZNF143 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH FAM71E1 EMC10 KLK2 ENSG00000269392
GH19F050357 1.5 FANTOM5 ENCODE 41.8 -13.8 -13785 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B ZNF2 YY1 ZNF143 ZNF207 NAPSB POLD1 AKT1S1 PRR12 PIH1D1 KCNC3 NUP62 NR1H2 CTU1 FLT3LG
GH19F050375 1.2 ENCODE 49.2 -32.1 -32055 2.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 NAPSB NUP62 SNORD35A POLD1 SNORD35B RRAS ALDH16A1 RPS11 PIH1D1 NR1H2
GH19F050361 1.1 Ensembl ENCODE 49.7 -16.8 -16834 0.8 HDGF ATF1 PKNOX1 ESRRA TAL1 NCOR1 NR2F6 CREM SMARCE1 SMARCA5 NAPSB POLD1 ENSG00000269392 NAPSA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAPSB on UCSC Golden Path with GeneCards custom track

Genomic Location for NAPSB Gene

Chromosome:
19
Start:
50,333,796 bp from pter
End:
50,344,767 bp from pter
Size:
10,972 bases
Orientation:
Minus strand

Genomic View for NAPSB Gene

Genes around NAPSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSB Gene

Proteins for NAPSB Gene

Post-translational modifications for NAPSB Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAPSB Gene

Domains & Families for NAPSB Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NAPSB Gene

Function for NAPSB Gene

Phenotypes for NAPSB Gene

GenomeRNAi human phenotypes for NAPSB:
genes like me logo Genes that share phenotypes with NAPSB: view

Animal Model Products

miRNA for NAPSB Gene

miRTarBase miRNAs that target NAPSB

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPSB Gene

Localization for NAPSB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NAPSB Gene

Pathways & Interactions for NAPSB Gene

SuperPathways for NAPSB Gene

No Data Available

Interacting Proteins for NAPSB Gene

Gene Ontology (GO) - Biological Process for NAPSB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAPSB Gene

Transcripts for NAPSB Gene

Unigene Clusters for NAPSB Gene

Napsin B aspartic peptidase, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for NAPSB Gene

GeneLoc Exon Structure for
NAPSB
ECgene alternative splicing isoforms for
NAPSB

Expression for NAPSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAPSB Gene

mRNA differential expression in normal tissues according to GTEx for NAPSB Gene

This gene is overexpressed in Spleen (x11.0), Whole Blood (x9.0), and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for NAPSB Gene

This gene is overexpressed in Lung (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for NAPSB Gene



Protein tissue co-expression partners for NAPSB Gene

NURSA nuclear receptor signaling pathways regulating expression of NAPSB Gene:

NAPSB

SOURCE GeneReport for Unigene cluster for NAPSB Gene:

Hs.636624
genes like me logo Genes that share expression patterns with NAPSB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NAPSB Gene

Orthologs for NAPSB Gene

Evolution for NAPSB Gene

ENSEMBL:
Gene Tree for NAPSB (if available)
TreeFam:
Gene Tree for NAPSB (if available)

No data available for Orthologs for NAPSB Gene

Paralogs for NAPSB Gene

No data available for Paralogs for NAPSB Gene

Variants for NAPSB Gene

Sequence variations from dbSNP and Humsavar for NAPSB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1035422 -- 50,335,956(-) CAAAC(C/T)AGGAA intron-variant, upstream-variant-2KB
rs10407715 -- 50,336,435(+) TAAGA(A/G)ACTTC intron-variant, upstream-variant-2KB
rs10411345 -- 50,333,427(+) GGGAA(C/G)GGTAT intron-variant
rs10418686 -- 50,333,729(+) TCAAC(C/T)CCGTG intron-variant, upstream-variant-2KB
rs10661355 -- 50,336,129(+) TTTTT(-/T)GGAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAPSB Gene

Variant ID Type Subtype PubMed ID
nsv523948 CNV gain 19592680
nsv953603 CNV deletion 24416366
nsv978835 CNV duplication 23825009
nsv2529 CNV insertion 18451855
nsv1152956 OTHER inversion 26484159
nsv1140251 OTHER inversion 24896259
nsv1133010 OTHER inversion 24896259
nsv1066389 CNV gain 25217958

Relevant External Links for NAPSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NAPSB Gene

Disorders for NAPSB Gene

Relevant External Links for NAPSB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPSB

No disorders were found for NAPSB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPSB Gene

Publications for NAPSB Gene

  1. Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PMID: 12151090) Cook M. … Kay J. (Biochim. Biophys. Acta 2002) 3 22 64
  2. Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity. (PMID: 10591213) Yan R. … Gurney M.E. (Nature 1999) 2 3 64
  3. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PMID: 9877162) Tatnell P.J. … Kay J. (FEBS Lett. 1998) 2 3 64
  4. Structural and phylogenetic comparison of napsin genes: the duplication, loss of function and human-specific pseudogenization of napsin B. (PMID: 23333608) Nishishita K. … Tsukuba T. (Gene 2013) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for NAPSB Gene

Sources for NAPSB Gene

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