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napsin B aspartic peptidase, pseudogene
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Aliases
for NAPSB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Napsin B Aspartic Peptidase, Pseudogene1 2 | | NAP1L1 2 | | NAP21 2 | | NAPB1 2 | | NAPSBP1 2 |
| External Ids: | HGNC: 133961 | Entrez Gene: 2562362 | Ensembl: ENSG000001314017 | | ORGUL members: | |
|---|
| NONCODE:n405633 | |
Export aliases for NAPSB gene to outside databasesPrevious GC identifers: GC19M055530 GC19M055531 GC19M047175
|---|
Summaries
for NAPSB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NAPSB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAPSB gene promoter:
CREB TBP Brachyury Bach2 NF-kappaB NF-kappaB1 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAPSB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPSB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33NAPSB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M050837: view genomic region
(about GC identifiers)
Start:
|
50,837,053 bp from pter |
End:
|
50,848,024 bp from pter |
Size:
|
10,972 bases |
Orientation:
|
minus strand |
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Proteins
for NAPSB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB: --
|
Protein
Domains /
Families
for NAPSB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for NAPSB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPSB |
|
Pathways & Interactions
for NAPSB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAPSB
|
Drugs & Compounds
for NAPSB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NAPSB
Search CenterWatch for drugs/clinical trials and news about NAPSB 
|
Transcripts
for NAPSB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for NAPSB: Napsin B aspartic peptidase, pseudogene Hs.636624 [show with all ESTs]Unigene Representative Sequence: NR_0027986 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531692 ENST00000527780(uc002prw.3) ENST00000562112 ENST00000534096
ENST00000534789 ENST00000525179
Additional cDNA sequence: AF090387.1 AF098485.1 AF200344.1 AK300884.1 AK310134.1 BC006149.1 BC019048.2 BC032360.1 BC040958.1 BC053864.1 BC065203.1 BC085008.1 BC111705.1 NR_002798.1 6 DOTS entries: DT.115036 DT.121420480 DT.95244708 DT.40262867 DT.91952801 DT.99998492 24/215 AceView cDNA sequences (see all 215): BX111968 CR619860 BQ016871 BI764577 BC053864 BM988961 BQ055704 AW183525 AA279744 BQ712631 AW139459 AI056559 AF090386 BM921728 CA307403 BM972069 BP340501 BU688522 AF098485 BC006149 BQ030449 AF200344 BI823670 AI500067
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NAPSB About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NAPSB
|
Expression
for NAPSB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAPSB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCACCGGGT
About this image
Genevestigator expression for NAPSB
SOURCE GeneReport for Unigene cluster: Hs.636624
SABiosciences Custom PCR Arrays for NAPSB
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAPSB
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NAPSB | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAPSB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPSB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPSB |
Orthologs
for NAPSB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for NAPSB (if available)
TreeFam Gene Tree for NAPSB (if available) |
Paralogs
for NAPSB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NAPSB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAPSB (50837053 - 50848024 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAPSB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAPSB |
|
Disorders
/ Diseases
for NAPSB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAPSB for disorders About GeneDecksing
1  disease for NAPSB: About MalaCardsalzheimer's disease
Export disorders for NAPSB gene to outside databases
|
Publications
for NAPSB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAPSB gene integrated from 9 sources:
(articles sorted by number of sources associating them with NAPSB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity. (PubMed id 10591213)1, 3 Yan R.... Gurney M.E. (1999)
- Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PubMed id 9877162)1, 3 Tatnell P.J.... Kay J. (1998)
- Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PubMed id 12151090)1, 9 Cook M....Kay J. (2002)
- Structural and phylogenetic comparison of napsin genes : The duplication, loss of function and human-specific pseudogenization of napsi n B. (PubMed id 23333608)1 Nishishita K....Tsukuba T. (2013)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NAPSB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAPSB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAPSB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAPSB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAPSB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAPSB gene:
Search GeneIP for patents involving NAPSB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAPSB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAPSB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAPSB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPSB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPSB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPSB | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAPSB |
| |
 |  |  |  | |
| | | | Search Tocris compounds for NAPSB |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPSB |
|  |  |  | | | | Search ThermoFisher Antibodies for NAPSB |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NAPSB |
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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