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Aliases for NAPSB Gene

Aliases for NAPSB Gene

  • Napsin B Aspartic Peptidase, Pseudogene 2 3 5
  • Napsin A Aspartic Peptidase Pseudogene 3
  • Napsin B Pseudogene 3
  • Napsin-A Pseudogene 3
  • Pronapsin B 3
  • Napsin 2 3
  • NAPSBP 3
  • NAP1L 3
  • NAP2 3
  • NAPB 3

External Ids for NAPSB Gene

Previous GeneCards Identifiers for NAPSB Gene

  • GC19M055530
  • GC19M055531
  • GC19M050837
  • GC19M047175

Summaries for NAPSB Gene

GeneCards Summary for NAPSB Gene

NAPSB (Napsin B Aspartic Peptidase, Pseudogene) is a Pseudogene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSB Gene

Genomics for NAPSB Gene

Regulatory Elements for NAPSB Gene

Enhancers for NAPSB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G050340 1.2 Ensembl ENCODE 76 +1.8 1771 5.6 HDGF PKNOX1 CREB3L1 ZNF121 CBX5 ZNF143 ZNF207 JUNB TBX21 GLIS1 NAPSB KCNC3
GH19G050346 1.2 Ensembl ENCODE 71.9 -3.3 -3263 3.9 PKNOX1 ATF1 FOXA2 ARID4B DMAP1 ZNF48 ZNF143 JUNB MIER2 TBX21 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH EMC10 FAM71E1 KLK2 ENSG00000269392
GH19G050356 2 FANTOM5 Ensembl ENCODE dbSUPER 41.9 -13.7 -13725 3.0 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF766 NAPSB KCNC3 POLD1 FLT3LG LINC01869 C19orf48 SNORD88C FCGRT PNKP NR1H2
GH19G050375 1.4 ENCODE dbSUPER 49.2 -32.1 -32055 2.1 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 ZNF610 GLIS1 NAPSB SNORD35B ALDH16A1 SNORD35A POLD1 RPS11 PIH1D1 NUP62 FLT3LG PNKP
GH19G050368 1.3 ENCODE dbSUPER 40 -24.3 -24290 1.8 ARNT SIN3A ZNF2 ZNF48 YY1 ZNF143 ZNF207 FOS REST KAT8 NAPSB ENSG00000269392 NAPSA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAPSB on UCSC Golden Path with GeneCards custom track

Genomic Location for NAPSB Gene

Chromosome:
19
Start:
50,333,796 bp from pter
End:
50,344,767 bp from pter
Size:
10,972 bases
Orientation:
Minus strand

Genomic View for NAPSB Gene

Genes around NAPSB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPSB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPSB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSB Gene

Proteins for NAPSB Gene

Post-translational modifications for NAPSB Gene

No Post-translational modifications

No data available for DME Specific Peptides for NAPSB Gene

Domains & Families for NAPSB Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for NAPSB Gene

Function for NAPSB Gene

Phenotypes for NAPSB Gene

GenomeRNAi human phenotypes for NAPSB:
genes like me logo Genes that share phenotypes with NAPSB: view

Animal Model Products

miRNA for NAPSB Gene

miRTarBase miRNAs that target NAPSB

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPSB Gene

Localization for NAPSB Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NAPSB Gene

Pathways & Interactions for NAPSB Gene

SuperPathways for NAPSB Gene

No Data Available

Interacting Proteins for NAPSB Gene

Gene Ontology (GO) - Biological Process for NAPSB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NAPSB Gene

Transcripts for NAPSB Gene

Unigene Clusters for NAPSB Gene

Napsin B aspartic peptidase, pseudogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2:
SP3: - - - - -
SP4:

Relevant External Links for NAPSB Gene

GeneLoc Exon Structure for
NAPSB
ECgene alternative splicing isoforms for
NAPSB

Expression for NAPSB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPSB Gene

mRNA differential expression in normal tissues according to GTEx for NAPSB Gene

This gene is overexpressed in Spleen (x11.0), Whole Blood (x9.0), and Small Intestine - Terminal Ileum (x4.3).

Protein differential expression in normal tissues from HIPED for NAPSB Gene

This gene is overexpressed in Lung (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for NAPSB Gene



Protein tissue co-expression partners for NAPSB Gene

NURSA nuclear receptor signaling pathways regulating expression of NAPSB Gene:

NAPSB

SOURCE GeneReport for Unigene cluster for NAPSB Gene:

Hs.636624
genes like me logo Genes that share expression patterns with NAPSB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPSB Gene

Orthologs for NAPSB Gene

Evolution for NAPSB Gene

ENSEMBL:
Gene Tree for NAPSB (if available)
TreeFam:
Gene Tree for NAPSB (if available)

No data available for Orthologs for NAPSB Gene

Paralogs for NAPSB Gene

No data available for Paralogs for NAPSB Gene

Variants for NAPSB Gene

Sequence variations from dbSNP and Humsavar for NAPSB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000088982 -- 50,335,703(+) TCTTG(A/G)GTGGG intron-variant, upstream-variant-2KB
rs1000121439 -- 50,335,519(+) CGAAG(G/T)TGTGA intron-variant
rs1000451456 -- 50,341,441(+) GTTTT(A/G)TTAGA intron-variant
rs1000752533 -- 50,336,812(+) CTGGA(C/G)CCAAG intron-variant, upstream-variant-2KB
rs1000819043 -- 50,346,107(+) CCTCA(C/T)GATCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAPSB Gene

Variant ID Type Subtype PubMed ID
nsv1066389 CNV gain 25217958
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv2529 CNV insertion 18451855
nsv523948 CNV gain 19592680
nsv953603 CNV deletion 24416366
nsv978835 CNV duplication 23825009

Relevant External Links for NAPSB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPSB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NAPSB Gene

Disorders for NAPSB Gene

Relevant External Links for NAPSB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPSB

No disorders were found for NAPSB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPSB Gene

Publications for NAPSB Gene

  1. Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PMID: 12151090) Cook M. … Kay J. (Biochim. Biophys. Acta 2002) 3 22 64
  2. Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity. (PMID: 10591213) Yan R. … Gurney M.E. (Nature 1999) 2 3 64
  3. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PMID: 9877162) Tatnell P.J. … Kay J. (FEBS Lett. 1998) 2 3 64
  4. Structural and phylogenetic comparison of napsin genes: the duplication, loss of function and human-specific pseudogenization of napsin B. (PMID: 23333608) Nishishita K. … Tsukuba T. (Gene 2013) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for NAPSB Gene

Sources for NAPSB Gene

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