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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAPSA Gene

protein-coding   GIFtS: 56
GCID: GC19M050861

napsin A aspartic peptidase
 Explore 17 diseases affiliated with
NAPSA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NAPSA    

Aliases
for NAPSA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Napsin A Aspartic Peptidase1 2     Kidney-Derived Aspartic Protease-Like Protein2
NAP11 2 3 5     Napsin-13
NAPA1 2 3 5     Napsin-A1
KAP1 2     Pronapsin A2
Kdap1 2     EC 3.4.23.-3
Asp 42 3     Napsin-13
Aspartyl Protease 42 3     EC 3.4.238
ASP42 3     EC 3.4.23.158
TA01/TA022 3     EC 3.4.23.38
SNAPA2 5     EC 3.4.23.58

External Ids:    HGNC: 133951   Entrez Gene: 94762   Ensembl: ENSG000001314007   OMIM: 6056315   UniProtKB: O960093   

Export aliases for NAPSA gene to outside databases

Previous GC identifers: GC19M055554 GC19M055555 GC19M047199


Summaries
for NAPSA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NAPSA:
The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or
pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase
zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to
be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18
residues at its C-terminus. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
Function: May be involved in processing of pneumocyte surfactant precursors

Gene Wiki entry for NAPSA


Genomic Views
for NAPSA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAPSA gene promoter:
         Elk-1   HOXA3   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAPSA promoter sequence
   Search SABiosciences Chromatin IP Primers for NAPSA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPSA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

NAPSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPSA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050861:  view genomic region     (about GC identifiers)

Start:
 50,861,734 bp from pter      End:
 50,868,931 bp from pter
Size:
 7,198 bases      Orientation:
 minus strand

Proteins
for NAPSA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009 (See protein sequence)
Recommended Name: Napsin-A precursor  
Size: 420 amino acids; 45387 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q8WWD9

Explore the universe of human proteins at neXtProt for NAPSA: NX_O96009

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O96009

    • 4/8 DME Specific Peptides for NAPSA (O96009) (see all 8)
     VLGGSDP  PVFSFYL  ILGDVFL  AYWQIHM 

    NAPSA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004842.1  
    ENSEMBL proteins: 
     ENSP00000253719  

    Human Recombinant Protein Products: 
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    Novus Biologicals NAPSA Protein
    Novus Biologicals NAPSA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NAPSA

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA18216060
    GO:0005764lysosome IDA14766755
    GO:0042599lamellar body ----
    GO:0097208alveolar lamellar body IDA18216060


    NAPSA for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NAPSA

    Protein Domains /
    Families
    for NAPSA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NAPSA for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR021109 Peptidase_aspartic
     IPR001461 Peptidase_A1
     IPR001969 Peptidase_aspartic_AS

    Graphical View of Domain Structure for InterPro Entry O96009

    ProtoNet protein and cluster: O96009

    1 Blocks protein family: IPB001461 Pepsin (A1) aspartic protease family signature

    UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
    Similarity: Belongs to the peptidase A1 family


    Function
    for NAPSA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
    Function: May be involved in processing of pneumocyte surfactant precursors

    Enzyme Numbers (IUBMB): EC 3.4.232 EC 3.4.23.52 EC 3.4.23.32 EC 3.4.23.-1 EC 3.4.23.152

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAPSA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAPSA (see all 7)
    OriGene shRNA RFP: NAPSA
    OriGene siRNA: NAPSA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPSA

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NAPSA

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAPSA (see all 3)
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    Search LifeMap BioReagents cell lines for NAPSA

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity IDA14766755
    GO:0004190aspartic-type endopeptidase activity NAS9877162
    GO:0008233peptidase activity IDA18216060


    NAPSA for ontologies           About GeneDecksing



    Pathways & Interactions
    for NAPSA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Lysosome
    		Lysosome1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for NAPSA):
        Lysosome


    NAPSA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAPSA

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for NAPSA (O960092, 3 ENSP000002537194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3318098 I2D: score=1 STRING: ENSP00000309503
    --ENSP000003060434STRING: ENSP00000306043
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS9877162
    GO:0033619membrane protein proteolysis IDA14766755
    GO:0043129surfactant homeostasis IDA18216060


    NAPSA for ontologies           About GeneDecksing



    Drugs & Compounds
    for NAPSA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAPSA
    Search CenterWatch for drugs/clinical trials and news about NAPSA 

    Transcripts
    for NAPSA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NAPSA gene: 
    NM_004851.1  

    Unigene Cluster for NAPSA:

    Napsin A aspartic peptidase
    Hs.512843  [show with all ESTs]
    Unigene Representative Sequence: AF098484
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000253719(uc002prx.3)

    miRNA
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    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAPSA (see all 7)
    OriGene shRNA RFP: NAPSA
    OriGene siRNA: NAPSA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPSA
    Clone
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    Additional cDNA sequence: 

    AF090386.1 AF098484.1 AF200345.1 AK308013.1 AK314364.1 BC017842.1 BC029397.1 

    9 DOTS entries:

    DT.100023953  DT.97846383  DT.115036  DT.40206656  DT.95244686  DT.91642990  DT.95244706  DT.121420516 
    DT.95244712 

    24/215 AceView cDNA sequences (see all 215):

    AI734145 BQ030449 AF200344 BI823670 BU541597 AI500067 BC065203 AF090387 
    BM992609 NM_004851 BM996247 CA435746 BE675393 AI218262 AF098484 AI005080 
    BG540257 BQ019267 BQ058202 BC019048 AA485027 BC032360 AI086028 AF200345 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:              -     -                 -                                                   
    SP2:                                -     -                                                   
    SP3:              -     -           -     -                                                   
    SP4:                                      -     -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NAPSA

    Expression
    for NAPSA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAPSA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGCAGCGGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NAPSA expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyLoop of HenleLoop of Henle CellsKidney
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyLoop of HenleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NAPSA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAPSA

    SOURCE GeneReport for Unigene cluster: Hs.512843

    UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
    Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low
    levels in adult spleen and very low levels in peripheral blood leukocytes

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    In Situ
    Assay Products:     
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    Orthologs
    for NAPSA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAPSA gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Napsa1 , 5 napsin A aspartic peptidase1, 5 77.89(n)1
    71.95(a)1    		   7 (28.84 cM)5
    165411  NM_008437.11  NP_032463.11 
     445724325 
    lizard
    (Anolis carolinensis)    		 Reptilia NAPSA6
    		 --
    		 44(a)
    		 1 ↔ 1
    		 GL343287.1(260983-282680)
    fruit fly
    (Drosophila melanogaster)    		 Insecta cathD6
    CG101046
    (see all 12)    		 --
    		 48(a)
    41(a)
    (see all 12)    		 many ↔ many
    many ↔ many
    (see all 12)    		 2R(3709615-3711073)
    2R(10278291-10279831)
    worm
    (Caenorhabditis elegans)    		 Secernentea asp-46
    asp-36
    		 Aspartic protease 3
    		 40(a)
    39(a)
    		 many ↔ many
    many ↔ many
    		 X(13218908-13221400)
    X(6791025-6792676)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G220506
    APA16
    (see all 4)    		 aspartic proteinase A1
    (see all 4)    		 35(a)
    33(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 4(11683865-11685644)
    1(4016784-4020983)
    rice
    (Oryza sativa)    		 Liliopsida D12777.12   -- 71.88(n)    D12777.1 


    ENSEMBL Gene Tree for NAPSA (if available)
    TreeFam Gene Tree for NAPSA (if available) 

    Paralogs
    for NAPSA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAPSA gene
    PGA52  BACE12  CTSD2  PGA32  BACE22  ENSG000002659692  PGA42  REN2  
    ENSG000002506442  CTSE2  PGC2  
    7 SIMAP similar genes for NAPSA using alignment to 2 protein entries:     NAPSA_HUMAN (see all proteins):
    CTSD    CTSE    REN    PGA3    PGA4    PGA5
    PGC

    NAPSA for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NAPSA
    PGOHUM00000258062


    Genomic Variants
    for NAPSA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/209 NCBI SNPs in NAPSA are shown (see all 209)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs764327081,2
    		F,--50861252(+) GGAAGG/ATAGCG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1902546551,2
    		--50861257(+) GTAGCG/TTAGGC 1 -- ds50010--------
    rs1455570391,2
    		--50861260(+) GCGTAA/GGCGAG 1 -- ds50010--------
    rs765037071,2
    		F,--50861388(+) TTATTA/GTTTTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1825319921,2
    		--50861428(+) GAGTGC/TAATGG 1 -- ds50010--------
    rs1148319771,2
    		F,--50861702(+) AGTACG/ACTCTG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1850867971,2
    		--50861705(+) ACGCTC/GTGAAA 1 -- ds50010--------
    rs1129962641,2
    		C,F,--50861851(+) TCCGAG/CGTCCG 2 /L /V mis12Minor allele frequency- C:0.01CSA NA 2444
    rs2021097801,2
    		C,--50861884(+) CAGGCC/TCACCC 2 S G mis10--------
    rs1812294821,2
    		C,--50862004(+) GAAACA/CGGACA 2 G C mis10--------

    HapMap Linkage Disequilibrium report for NAPSA (50861734 - 50868931 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NAPSA: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAPSA
    DNA2.0 Custom Variant and Variant Library Synthesis for NAPSA

    Disorders / Diseases
    for NAPSA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NAPSA for disorders           About GeneDecksing

    OMIM gene information: 605631    OMIM disorders: --

    17 diseases for NAPSA:    About MalaCards
    non-small cell lung carcinoma    sarcomatoid mesothelioma    sclerosing hemangioma    haemophilus influenzae
    malignant mesothelioma    lung carcinoma    hemangioma    influenza
    adenocarcinoma    lung adenocarcinoma    carcinoma    alzheimer's disease
    colorectal cancer    lung cancer    thyroiditis    malaria
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for NAPSA:
    Adenocarcinoma     Lung cancer

    7 Novoseek disease relationships for NAPSA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma lung 75.5 12 16259111 (6), 11050472 (1), 15221555 (1), 10580105 (1) (see all 6)
    lung carcinoma 67.8 4 16259111 (2), 20173733 (1)
    adenocarcinoma 51.5 21 16259111 (4), 19740516 (4), 17636482 (2), 20173733 (2) (see all 8)
    carcinoma renal cell 38.6 3 19740516 (3)
    metastasis 31.4 3 17636482 (1), 20173733 (1), 19944198 (1)
    cancer lung 30.6 1 12151090 (1)
    tumors 14.9 6 19740516 (2), 15221555 (1), 15754301 (1), 17636482 (1) (see all 5)


    Export disorders for NAPSA gene to outside databases

    Publications
    for NAPSA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAPSA gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with NAPSA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. (PubMed id 10580105)1, 2, 9 Chuman Y.... Linder S. (1999)
    2. Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity. (PubMed id 10591213)1, 2 Yan R.... Gurney M.E. (1999)
    3. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PubMed id 9877162)1, 2 Tatnell P.J.... Kay J. (1998)
    4. Napsin A and thyroid transcription factor-1 expressio n in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and mali gnant mesothelioma. (PubMed id 19740516)1, 9 Bishop J.A....Illei P.B. (2010)
    5. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. (PubMed id 13129928)1, 9 Brasch F....Buhling F. (2003)
    6. Human napsin A: expression, immunochemical detection, and tissue localization. (PubMed id 10580106)1, 9 Schauer-Vukasinovic V....Giller T. (1999)
    7. The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. (PubMed id 18195689)1, 9 Ueno T....Linder S. (2008)
    8. Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PubMed id 12151090)1, 9 Cook M....Kay J. (2002)
    9. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. (PubMed id 18216060)1, 9 Woischnik M....Griese M. (2008)
    10. Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. (PubMed id 12698189)1, 9 Ueno T....Elmberger G. (2003)

    External Searches for NAPSA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NAPSA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9476 HGNC: 13395 AceView: NAPSAandNAPSB Ensembl:ENSG00000131400 euGenes: HUgn9476
    ECgene: NAPSA Kegg: 9476 H-InvDB: NAPSA

    Other Databases showing NAPSA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NAPSA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAPSA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NAPSA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NAPSA gene:
    Search GeneIP for patents involving NAPSA

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