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Aliases for NAPSA Gene

Aliases for NAPSA Gene

  • Napsin A Aspartic Peptidase 2 3
  • Kidney-Derived Aspartic Protease-Like Protein 2 3
  • Aspartyl Protease 4 3 4
  • TA01/TA02 3 4
  • Napsin-1 3 4
  • Asp 4 3 4
  • NAP1 3 4
  • ASP4 3 4
  • NAPA 3 4
  • CTB-191K22.6 3
  • EC 3.4.23.15 63
  • Pronapsin A 3
  • EC 3.4.23.5 63
  • EC 3.4.23.3 63
  • EC 3.4.23.- 4
  • EC 3.4.23 63
  • SNAPA 3
  • KDAP 3
  • KAP 3

External Ids for NAPSA Gene

Previous GeneCards Identifiers for NAPSA Gene

  • GC19M055554
  • GC19M055555
  • GC19M050861
  • GC19M047199
  • GC19M050366

Summaries for NAPSA Gene

Entrez Gene Summary for NAPSA Gene

  • The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAPSA Gene

NAPSA (Napsin A Aspartic Peptidase) is a Protein Coding gene. Diseases associated with NAPSA include ovarian clear cell adenofibroma and thymus adenocarcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Lysosome. GO annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for NAPSA Gene

  • May be involved in processing of pneumocyte surfactant precursors

Gene Wiki entry for NAPSA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSA Gene

Genomics for NAPSA Gene

Regulatory Elements for NAPSA Gene

Genomic Location for NAPSA Gene

Chromosome:
19
Start:
50,358,472 bp from pter
End:
50,369,331 bp from pter
Size:
10,860 bases
Orientation:
Minus strand

Genomic View for NAPSA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSA Gene

Proteins for NAPSA Gene

  • Protein details for NAPSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96009-NAPSA_HUMAN
    Recommended name:
    Napsin-A
    Protein Accession:
    O96009
    Secondary Accessions:
    • Q8WWD9

    Protein attributes for NAPSA Gene

    Size:
    420 amino acids
    Molecular mass:
    45387 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAPSA Gene

Proteomics data for NAPSA Gene at MOPED

Selected DME Specific Peptides for NAPSA Gene

Post-translational modifications for NAPSA Gene

  • Glycosylation at Asn 90, Asn 133, and Asn 336
  • Modification sites at PhosphoSitePlus

Other Protein References for NAPSA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for NAPSA Gene

Suggested Antigen Peptide Sequences for NAPSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O96009

UniProtKB/Swiss-Prot:

NAPSA_HUMAN :
  • Contains 1 peptidase A1 domain.
  • Belongs to the peptidase A1 family.
Domain:
  • Contains 1 peptidase A1 domain.
Family:
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with NAPSA: view

No data available for Gene Families for NAPSA Gene

Function for NAPSA Gene

Molecular function for NAPSA Gene

UniProtKB/Swiss-Prot Function:
May be involved in processing of pneumocyte surfactant precursors

Enzyme Numbers (IUBMB) for NAPSA Gene

Gene Ontology (GO) - Molecular Function for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 14766755
GO:0004190 aspartic-type endopeptidase activity NAS 9877162
GO:0005515 protein binding --
GO:0008233 peptidase activity IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view
genes like me logo Genes that share phenotypes with NAPSA: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPSA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAPSA Gene

Localization for NAPSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPSA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPSA Gene COMPARTMENTS Subcellular localization image for NAPSA gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18216060
GO:0005764 lysosome IDA 14766755
GO:0070062 extracellular exosome IDA 19056867
GO:0097208 alveolar lamellar body IDA 18216060
GO:0097486 multivesicular body lumen TAS --
genes like me logo Genes that share ontologies with NAPSA: view

Pathways & Interactions for NAPSA Gene

genes like me logo Genes that share pathways with NAPSA: view

Pathways by source for NAPSA Gene

Interacting Proteins for NAPSA Gene

Gene Ontology (GO) - Biological Process for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 9877162
GO:0030163 protein catabolic process IBA --
GO:0033619 membrane protein proteolysis IDA 14766755
GO:0043129 surfactant homeostasis IDA 18216060
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with NAPSA: view

No data available for SIGNOR curated interactions for NAPSA Gene

Drugs & Compounds for NAPSA Gene

(1) Drugs for NAPSA Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pepstatin A Pharma Aspartic proteinases inhibitor 0
genes like me logo Genes that share compounds with NAPSA: view

Transcripts for NAPSA Gene

Unigene Clusters for NAPSA Gene

Napsin A aspartic peptidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPSA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5:
SP6:

Relevant External Links for NAPSA Gene

GeneLoc Exon Structure for
NAPSA
ECgene alternative splicing isoforms for
NAPSA

Expression for NAPSA Gene

mRNA expression in normal human tissues for NAPSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAPSA Gene

This gene is overexpressed in Lung (x39.1) and Kidney - Cortex (x9.7).

Protein differential expression in normal tissues from HIPED for NAPSA Gene

This gene is overexpressed in Urine (42.8) and Lung (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAPSA Gene



SOURCE GeneReport for Unigene cluster for NAPSA Gene Hs.512843

mRNA Expression by UniProt/SwissProt for NAPSA Gene

O96009-NAPSA_HUMAN
Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes
genes like me logo Genes that share expression patterns with NAPSA: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for NAPSA Gene

Orthologs for NAPSA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPSA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAPSA 35
  • 85.12 (n)
  • 80.94 (a)
NAPSA 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPSA 35
  • 84.41 (n)
  • 79.35 (a)
NAPSA 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napsa 35
  • 78.45 (n)
  • 72.18 (a)
Napsa 16
Napsa 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAPSA 35
  • 99.29 (n)
  • 98.57 (a)
NAPSA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napsa 35
  • 78.56 (n)
  • 71.86 (a)
oppossum
(Monodelphis domestica)
Mammalia NAPSA 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPSA 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii NAPSA 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cathD 36
  • 48 (a)
ManyToMany
CG10104 36
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea asp-4 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8194 36
  • 45 (a)
ManyToMany
Species with no ortholog for NAPSA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAPSA Gene

ENSEMBL:
Gene Tree for NAPSA (if available)
TreeFam:
Gene Tree for NAPSA (if available)

Paralogs for NAPSA Gene

Paralogs for NAPSA Gene

(7) SIMAP similar genes for NAPSA Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NAPSA Gene

genes like me logo Genes that share paralogs with NAPSA: view

Variants for NAPSA Gene

Sequence variations from dbSNP and Humsavar for NAPSA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs599100 -- 50,364,472(+) tagcc(A/G)ggcgt intron-variant
rs634713 -- 50,359,928(-) CTGGC(A/G)ATACC intron-variant
rs638294 -- 50,359,766(-) GTCCC(C/T)GCCTA synonymous-codon, reference
rs676314 - 50,362,278(-) CAGGA(C/T)CCTGA missense, reference
rs873834 -- 50,365,745(-) GTCAC(C/T)TGCGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NAPSA Gene

Variant ID Type Subtype PubMed ID
dgv3976n71 CNV Loss 21882294
nsv2529 CNV Insertion 18451855
nsv912281 CNV Loss 21882294
nsv912282 CNV Loss 21882294

Variation tolerance for NAPSA Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPSA Gene

HapMap Linkage Disequilibrium report
NAPSA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPSA Gene

Disorders for NAPSA Gene

MalaCards: The human disease database

(5) MalaCards diseases for NAPSA Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell adenofibroma
thymus adenocarcinoma
  • adenocarcinoma of the thymus
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
lung cancer susceptibility 3
  • lung adenocarcinoma
lung cancer
  • lung cancer, protection against
- elite association
Search NAPSA in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAPSA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPSA
genes like me logo Genes that share disorders with NAPSA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPSA Gene

Publications for NAPSA Gene

  1. A study of immunohistochemical differential expression in pulmonary and mammary carcinomas. (PMID: 20173733) Yang M. … Nonaka D. (Mod. Pathol. 2010) 23 67
  2. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. (PMID: 19740516) Bishop J.A. … Illei P.B. (Hum. Pathol. 2010) 23 67
  3. Proteomic analysis of laser-microdissected paraffin-embedded tissues: (2) MRM assay for stage-related proteins upon non-metastatic lung adenocarcinoma. (PMID: 19944198) Nishimura T. … Kato H. (J Proteomics 2010) 23 67
  4. Identification and characterization of an androgen-responsive Kap promoter enhancer located in the intron II region of human angiotensinogen gene. (PMID: 20153828) Fan L.Q. … Li S.X. (J. Steroid Biochem. Mol. Biol. 2010) 23 67
  5. Resistance of Haemophilus influenzae to reactive nitrogen donors and gamma interferon-stimulated macrophages requires the formate-dependent nitrite reductase regulator-activated ytfE gene. (PMID: 19289513) Harrington J.C. … Akerley B.J. (Infect. Immun. 2009) 23 67

Products for NAPSA Gene

Sources for NAPSA Gene

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