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NAPSA Gene

protein-coding   GIFtS: 59
GCID: GC19M050861

Napsin A Aspartic Peptidase

  See NAPSA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Napsin A Aspartic Peptidase1 2     Kdap2
NAP12 3 5     napsin-12
NAPA2 3 5     napsin-A2
Kidney-Derived Aspartic Protease-Like Protein1 2     Pronapsin A2
Asp 42 3     EC 3.4.23.-3
Aspartyl Protease 42 3     Napsin-13
ASP42 3     EC 3.4.238
TA01/TA022 3     EC 3.4.23.158
SNAPA2 5     EC 3.4.23.38
KAP2     EC 3.4.23.58

External Ids:    HGNC: 133951   Entrez Gene: 94762   Ensembl: ENSG000001314007   OMIM: 6056315   UniProtKB: O960093   
ORGUL members:         

Export aliases for NAPSA gene to outside databases

Previous GC identifers: GC19M055554 GC19M055555 GC19M047199


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAPSA Gene:
The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide
segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of
aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation
product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif
and an additional 18 residues at its C-terminus. (provided by RefSeq, Jul 2008)

GeneCards Summary for NAPSA Gene:
NAPSA (napsin A aspartic peptidase) is a protein-coding gene. Diseases associated with NAPSA include sarcomatoid mesothelioma, and lung squamous cell carcinoma. GO annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
Function: May be involved in processing of pneumocyte surfactant precursors

Gene Wiki entry for NAPSA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAPSA gene promoter:
         Elk-1   HOXA3   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAPSA promoter sequence
   Search Chromatin IP Primers for NAPSA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAPSA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

NAPSA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPSA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050861:  view genomic region     (about GC identifiers)

Start:
50,861,734 bp from pter      End:
50,869,087 bp from pter
Size:
7,354 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009 (See protein sequence)
Recommended Name: Napsin-A precursor  
Size: 420 amino acids; 45387 Da
Secondary accessions: Q8WWD9

Explore the universe of human proteins at neXtProt for NAPSA: NX_O96009

Explore proteomics data for NAPSA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn90, Asn133, Asn336
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NAPSA (O96009) (see all 8)
     VLGGSDP  PVFSFYL  ILGDVFL  WILGDVF 


    See NAPSA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004842.1  
    ENSEMBL proteins: 
     ENSP00000253719   ENSP00000469061   ENSP00000469763  

    NAPSA Human Recombinant Protein Products:

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    antibodies-online proteins for NAPSA (3 products) 

     
    antibodies-online peptides for NAPSA

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    antibodies-online kits for NAPSA (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR021109 Peptidase_aspartic_dom
     IPR001969 Aspartic_peptidase_AS
     IPR001461 Aspartic_peptidase

    Graphical View of Domain Structure for InterPro Entry O96009

    ProtoNet protein and cluster: O96009

    1 Blocks protein domain: IPB001461 Pepsin (A1) aspartic protease family signature

    UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
    Similarity: Belongs to the peptidase A1 family


    Find genes that share domains with NAPSA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAPSA_HUMAN, O96009
    Function: May be involved in processing of pneumocyte surfactant precursors

         Enzyme Numbers (IUBMB): EC 3.4.232 EC 3.4.23.52 EC 3.4.23.32 EC 3.4.23.-1 EC 3.4.23.152

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004175endopeptidase activity IDA14766755
    GO:0004190aspartic-type endopeptidase activity NAS9877162
    GO:0005515protein binding ----
    GO:0008233peptidase activity IDA18216060
         
    Find genes that share ontologies with NAPSA           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NAPSA

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAPSA_HUMAN, O96009: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome5
    vacuole5
    cytosol1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA18216060
    GO:0005764lysosome IDA14766755
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0097208alveolar lamellar body IDA18216060

    Find genes that share ontologies with NAPSA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAPSA About    
    See pathways by source

    SuperPathContained pathways About
    1Lysosome
    Lysosome


    Find genes that share SuperPaths with NAPSA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for NAPSA):
        Lysosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAPSA
    Interactions:

        Search GeneGlobe Interaction Network for NAPSA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAPSA (O960092, 3 ENSP000002537194) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAZP631042, 3, ENSP000003095034MINT-3318098 I2D: score=1 STRING: ENSP00000309503
    SYVN1ENSP000003663954STRING: ENSP00000366395
    USO1ENSP000004116984STRING: ENSP00000411698
    SMAD4ENSP000003415514STRING: ENSP00000341551
    SSBP1ENSP000002653044STRING: ENSP00000265304
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS9877162
    GO:0033619membrane protein proteolysis IDA14766755
    GO:0043129surfactant homeostasis IDA18216060

    Find genes that share ontologies with NAPSA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAPSA



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAPSA gene: 
    NM_004851.1  

    Unigene Cluster for NAPSA:

    Napsin A aspartic peptidase
    Hs.512843  [show with all ESTs]
    Unigene Representative Sequence: AF098484
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253719(uc002prx.3) ENST00000598044 ENST00000599181 ENST00000598915
    ENST00000599233 ENST00000596653 ENST00000597378
    miRNA
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    Inhib. RNA
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAPSA (NM_004851)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPSA
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      QuantiTect SYBR Green Assays in human, mouse, rat NAPSA
      QuantiFast Probe-based Assays in human, mouse, rat NAPSA

    Additional mRNA sequence: 

    AF090386.1 AF098484.1 AF200345.1 AK308013.1 AK314364.1 BC017842.1 BC029397.1 

    9 DOTS entries:

    DT.100023953  DT.97846383  DT.115036  DT.40206656  DT.95244686  DT.91642990  DT.95244706  DT.121420516 
    DT.95244712 

    Selected AceView cDNA sequences (see all 215):

    BU688522 BM992609 BQ058202 BC032360 BM988961 AI056559 AI734145 AA485027 
    AF090387 BC065203 BQ019267 BU541597 AF200344 BC019048 BC053864 BM921728 
    CA307403 BE675393 BI823670 AI218262 BX111968 AF090386 BM996247 AF098485 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
    SP1:              -     -                 -                                                   
    SP2:                                -     -                                                   
    SP3:              -     -           -     -                                                   
    SP4:                                      -     -                                             
    SP5:                                                                                          


    ECgene alternative splicing isoforms for NAPSA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAPSA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCAGCGGGT
    NAPSA Expression
    About this image


    NAPSA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 6 entries
             Loop of Henle Cells Loop of Henle
             Metanephros
     
     Epithelial Cells
             Loop of Henle Cells Loop of Henle
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    NAPSA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAPSA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512843

    UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009
    Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low
    levels in adult spleen and very low levels in peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPSA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAPSA gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Napsa1 , 5 napsin A aspartic peptidase1, 5 78.45(n)1
    72.18(a)1
      7 (28.84 cM)5
    165411  NM_008437.11  NP_032463.11 
     445724325 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    40(a)
    many ↔ many
    1(35479654-35487259)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    39(a)
    many ↔ many
    GL343287.1(260983-282680)
    zebrafish
    (Danio rerio)
    Actinopterygii NAPSA6
    napsin A aspartic peptidase
    47(a)
    1 ↔ 1
    3(25222423-25234511) ENSDARG00000009313
    fruit fly
    (Drosophila melanogaster)
    Insecta cathD6
    CG101046
    --
    48(a)
    41(a)
    many ↔ many
    many ↔ many
    2R(3709615-3711073)
    2R(10278291-10279831)
    worm
    (Caenorhabditis elegans)
    Secernentea asp-46
    Protein ASP-4 (asp-4) mRNA, complete cds
    40(a)
    1 → many
    X(13218977-13221469) WBGene00000217
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PEP46
    Vacuolar aspartyl protease (proteinase A), require...
    39(a)
    1 → many
    XVI(259714-260931) YPL154C
    rice
    (Oryza sativa)
    Liliopsida D12777.12   -- 71.88(n)    D12777.1 


    ENSEMBL Gene Tree for NAPSA (if available)
    TreeFam Gene Tree for NAPSA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAPSA gene
    BACE12  CTSD2  PGA32  BACE22  CTSE2  PGC2  PGA52  REN2  
    PGA42  
    7 SIMAP similar genes for NAPSA using alignment to 2 protein entries:     NAPSA_HUMAN (see all proteins):
    CTSD    CTSE    PGA3    REN    PGA4    PGA5
    PGC

    Find genes that share paralogs with NAPSA           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NAPSA
    PGOHUM00000258062


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAPSA (see all 283)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs764327081,2
    F--50861252(+) GGAAGG/ATAGCG 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1902546551,2
    C--50861257(+) GTAGCG/TTAGGC 1 -- ds50010--------
    rs1455570391,2
    --50861260(+) GCGTAA/GGCGAG 1 -- ds50010--------
    rs765037071,2
    F--50861388(+) TTATTA/GTTTTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1825319921,2
    --50861428(+) GAGTGC/TAATGG 1 -- ds50010--------
    rs1148319771,2
    C,F--50861702(+) AGTACG/ACTCTG 1 -- ds50011Minor allele frequency- A:0.07WA 118
    rs1850867971,2
    --50861705(+) ACGCTC/GTGAAA 1 -- ds50010--------
    rs1129962641,2
    C,F--50861851(+) TCCGAG/CGTCCG 2 /L /V mis12Minor allele frequency- C:0.01CSA NA 2444
    rs2021097801,2
    C--50861884(+) CAGGCC/TCACCC 2 S G mis10--------
    rs1812294821,2
    C--50862004(+) GAAACA/CGGACA 2 G C mis10--------

    HapMap Linkage Disequilibrium report for NAPSA (50861734 - 50869087 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NAPSA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2529CNV Insertion18451855
    nsv912281CNV Loss21882294
    dgv3976n71CNV Loss21882294
    nsv912282CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605631    OMIM disorders: --

    3 diseases for NAPSA:    
    About MalaCards
    sarcomatoid mesothelioma    lung squamous cell carcinoma    lung adenocarcinoma

    2 diseases from the University of Copenhagen DISEASES database for NAPSA:
    Adenocarcinoma     Lung cancer

    Find genes that share disorders with NAPSA           About GenesLikeMe

    7 Novoseek inferred disease relationships for NAPSA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma lung 75.5 12 16259111 (6), 11050472 (1), 15221555 (1), 10580105 (1) (see all 6)
    lung carcinoma 67.8 4 16259111 (2), 20173733 (1)
    adenocarcinoma 51.5 21 16259111 (4), 19740516 (4), 17636482 (2), 20173733 (2) (see all 8)
    carcinoma renal cell 38.6 3 19740516 (3)
    metastasis 31.4 3 17636482 (1), 20173733 (1), 19944198 (1)
    cancer lung 30.6 1 12151090 (1)
    tumors 14.9 6 19740516 (2), 15221555 (1), 15754301 (1), 17636482 (1) (see all 5)


    Export disorders for NAPSA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAPSA gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with NAPSA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. (PubMed id 10580105)1, 2, 9 Chuman Y.... Linder S. (FEBS Lett. 1999)
    2. Membrane-anchored aspartyl protease with Alzheimer's disease beta- secretase activity. (PubMed id 10591213)1, 2 Yan R.... Gurney M.E. (Nature 1999)
    3. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PubMed id 9877162)1, 2 Tatnell P.J.... Kay J. (FEBS Lett. 1998)
    4. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. (PubMed id 19740516)1, 9 Bishop J.A....Illei P.B. (Hum. Pathol. 2010)
    5. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. (PubMed id 13129928)1, 9 Brasch F....Buhling F. (J. Biol. Chem. 2003)
    6. Human napsin A: expression, immunochemical detection, and tissue localization. (PubMed id 10580106)1, 9 Schauer-Vukasinovic V....Giller T. (FEBS Lett. 1999)
    7. The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. (PubMed id 18195689)1, 9 Ueno T....Linder S. ( a journal of technical methods and pathology 2008)
    8. Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PubMed id 12151090)1, 9 Cook M....Kay J. (Biochim. Biophys. Acta 2002)
    9. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. (PubMed id 18216060)1, 9 Woischnik M....Griese M. (Eur. Respir. J. 2008)
    10. Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. (PubMed id 12698189)1, 9 Ueno T....Elmberger G. (Br. J. Cancer 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9476 HGNC: 13395 AceView: NAPSAandNAPSB Ensembl:ENSG00000131400 euGenes: HUgn9476
    ECgene: NAPSA Kegg: 9476 H-InvDB: NAPSA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAPSA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NAPSA gene:
    Search GeneIP for patents involving NAPSA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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