Aliases for NAPSA Gene
External Ids for NAPSA Gene
Previous GeneCards Identifiers for NAPSA Gene
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]
GeneCards Summary for NAPSA Gene
NAPSA (Napsin A Aspartic Peptidase) is a Protein Coding gene. Diseases associated with NAPSA include Ovarian Clear Cell Adenofibroma and Krukenberg Carcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Surfactant metabolism. GO annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is CTSD.
UniProtKB/Swiss-Prot for NAPSA Gene
May be involved in processing of pneumocyte surfactant precursors.