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Aliases & Descriptions for NAPSA
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ASP4 3 | | EC 3.4.23.- 3 | | KAP 1, 2 | | Kdap 1, 2 | | NAP1 1, 2, 3 | | NAPA 1, 2, 3 | | Napsin-1 3 | | SNAPA 2 | | TA01/TA02 3 |
| | | Descriptions |
|---|
| Asp 4 3 | | Aspartyl protease 4 3 | | napsin A 2 | | napsin A aspartic peptidase 2 | | pronapsin A 2 |
|
| | Search outside databases for aliases for NAPSA genePrevious GC identifer: GC19M055554 |
Summaries for NAPSA(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAPSA: The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq] UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009Function: May be involved in processing of pneumocyte surfactant precursorsGene Wiki entry for NAPSA |
Genomic Location for NAPSA
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAPSA gene 
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33NAPSA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M055555:
(about GC identifiers)
Start:
|
55,553,546 bp from pter |
End:
|
55,560,743 bp from pter |
Size:
|
7,198 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for NAPSA
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009 (See
protein sequence)Recommended Name: Napsin-A precursor Size: 420 amino acids; 45387 Da
Secondary accessions: Q8WWD9REFSEQ proteins: NP_004842.1
ENSEMBL proteins: ENSP00000253719
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for NAPSA: Assays for NAPSA: | Protein
Domains/ Families for NAPSA(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O96009
ProtoNet protein and cluster: O96009 1 Blocks protein family: IPB001461 Pepsin (A1) aspartic protease family signature
UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009Similarity: Belongs to the peptidase A1 family | Gene Function for NAPSA
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004851
Applied Biosystems Silencer® siRNAs for NAPSA
Sigma-Aldrich siRNA and siRNA Panels for NAPSA  Sigma-Aldrich shRNA for NAPSA  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004851                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004851                                  untagged cDNA clone in CMV expression vector: NM_004851 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004851
UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009Function: May be involved in processing of pneumocyte surfactant precursorsEnzyme Number (IUBMB): EC 3.4.23.- 2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for NAPSA
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for NAPSA (O960092 ENSP000002537193) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for NAPSA(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAPSA
|
Transcripts for NAPSA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004851
Sigma-Aldrich siRNA and siRNA Panels for NAPSA  Sigma-Aldrich shRNA for NAPSA  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004851 REFSEQ mRNAs for NAPSA gene: NM_004851.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004851               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004851                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004851                                  untagged cDNA clone in CMV expression vector: NM_004851  Additional cDNA sequence: AF090386.1 AF098484.1 AF200345.1 AK308013.1 AK314364.1 BC017842.1 BC029397.1 CR619860.1 9 DOTS entries: DT.100023953 DT.97846383 DT.115036 DT.95244686 DT.40206656 DT.91642990 DT.95244706 DT.121420516 DT.95244712 24/215 AceView cDNA sequences (see all 215
):AI734145 BM996247 BU541597 AW139459 BM972069 BQ712631 AI005080 BI823670 AW183525 BQ058202 BU688522 AF090386 AF098484 BP340501 BM992609 BQ055704 AA279744 BM921728 BQ019267 BC006149 BC040958 BC053864 AF200345 BG540257
highest scoring ESTs for NAPSA:AA359075 AF090386 AF098484 AF200345 AW025398 BC017842 BF869544 BG537203 BG540257 BG541671 Unigene Cluster for NAPSA: Napsin A aspartic peptidase Hs.714418 [show with all ESTs]Unigene Representative Sequence: AF098484
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA (see all 6
)
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | |
| SP1: | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAPSA
1 Ensembl transcript including schematic representation: ENST00000253719
|
Expression for NAPSA
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAPSA expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAPSA
1 / 2 / 3 3 probe-sets matching NAPSA gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CGCAGCGGGT
SOURCE GeneReport for Unigene cluster: Hs.714418 UniProtKB/Swiss-Prot: NAPSA_HUMAN, O96009Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes |
Orthologs for NAPSA
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAPSA gene from 5/6 species (see all 6
)
About this table Species with no ortholog for NAPSA
ENSEMBL Gene Tree for NAPSA | Paralogs for NAPSA(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for NAPSA gene
- NAPSB2 BACE12 CTSD2 BACE22
|
SNPs/Variants for NAPSA(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAPSA (up to first 250kb)
|
Disorders & Mutations for NAPSA
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605631
6 Novoseek disease relationships for NAPSA gene
About this table
|
Medical News for NAPSA(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAPSA (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/35 PubMed articles for NAPSA gene (see all 35
):- Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. (PubMed id 10580105)1, 3, 4 Chuman Y.... Linder S. (1999)
- Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PubMed id 9877162)3, 4 Tatnell P.J.... Kay J. (1998)
- Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. (PubMed id 13129928)1, 3 Brasch F....Buhling F. (2003)
- Human napsin A: expression, immunochemical detection, and tissue localization. (PubMed id 10580106)1, 3 Schauer-Vukasinovic V....Giller T. (1999)
- The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. (PubMed id 18195689)1, 3 Ueno T....Linder S. (2008)
- Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells. (PubMed id 12151090)1, 3 Cook M....Kay J. (2002)
- Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. (PubMed id 18216060)1, 3 Woischnik M....Griese M. (2008)
- Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. (PubMed id 12698189)1, 3 Ueno T....Elmberger G. (2003)
- Abi1 is essential for the formation and activation of a WAVE2 signalling complex. (PubMed id 15048123)3 Innocenti M....Scita G. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for NAPSA
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAPSA
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAPSA
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAPSA(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAPSA(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAPSA:

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Incremental update: 13 Oct 2009
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