Aliases for NAPSA Gene
External Ids for NAPSA Gene
Previous GeneCards Identifiers for NAPSA Gene
The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]
GeneCards Summary for NAPSA Gene
NAPSA (Napsin A Aspartic Peptidase) is a Protein Coding gene. Diseases associated with NAPSA include sarcomatoid mesothelioma and lung squamous cell carcinoma. Among its related pathways are Lysosome and Clathrin derived vesicle budding. GO annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.
UniProtKB/Swiss-Prot for NAPSA Gene
May be involved in processing of pneumocyte surfactant precursors