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Aliases for NAPSA Gene

Aliases for NAPSA Gene

  • Napsin A Aspartic Peptidase 2 3
  • NAP1 3 4 6
  • NAPA 3 4 6
  • Kidney-Derived Aspartic Protease-Like Protein 2 3
  • Aspartyl Protease 4 3 4
  • TA01/TA02 3 4
  • Napsin-1 3 4
  • SNAPA 3 6
  • Asp 4 3 4
  • ASP4 3 4
  • CTB-191K22.6 3
  • EC 63
  • Pronapsin A 3
  • EC 63
  • EC 63
  • EC 3.4.23.- 4
  • EC 3.4.23 63
  • Napsin-A 3
  • KDAP 3
  • KAP 3

External Ids for NAPSA Gene

Previous GeneCards Identifiers for NAPSA Gene

  • GC19M055554
  • GC19M055555
  • GC19M050861
  • GC19M047199

Summaries for NAPSA Gene

Entrez Gene Summary for NAPSA Gene

  • The activation peptides of aspartic proteinases plays role as inhibitors of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus. [provided by RefSeq, Jul 2008]

GeneCards Summary for NAPSA Gene

NAPSA (Napsin A Aspartic Peptidase) is a Protein Coding gene. Diseases associated with NAPSA include sarcomatoid mesothelioma and lung squamous cell carcinoma. Among its related pathways are Lysosome and Clathrin derived vesicle budding. GO annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is BACE1.

UniProtKB/Swiss-Prot for NAPSA Gene

  • May be involved in processing of pneumocyte surfactant precursors

Gene Wiki entry for NAPSA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSA Gene

Genomics for NAPSA Gene

Regulatory Elements for NAPSA Gene

Genomic Location for NAPSA Gene

50,358,477 bp from pter
50,365,830 bp from pter
7,354 bases
Minus strand

Genomic View for NAPSA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSA Gene

Proteins for NAPSA Gene

  • Protein details for NAPSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8WWD9

    Protein attributes for NAPSA Gene

    420 amino acids
    Molecular mass:
    45387 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAPSA Gene

Proteomics data for NAPSA Gene at MOPED

Selected DME Specific Peptides for NAPSA Gene

Post-translational modifications for NAPSA Gene

  • Glycosylation at Asn90, Asn133, and Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for NAPSA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for NAPSA Gene

Suggested Antigen Peptide Sequences for NAPSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O96009
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with NAPSA: view

No data available for Gene Families for NAPSA Gene

Function for NAPSA Gene

Molecular function for NAPSA Gene

UniProtKB/Swiss-Prot Function: May be involved in processing of pneumocyte surfactant precursors

Enzyme Numbers (IUBMB) for NAPSA Gene

Gene Ontology (GO) - Molecular Function for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 14766755
GO:0004190 aspartic-type endopeptidase activity NAS 9877162
GO:0005515 protein binding --
GO:0008233 peptidase activity IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPSA

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAPSA Gene

Localization for NAPSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPSA Gene


Subcellular locations from

Jensen Localization Image for NAPSA Gene COMPARTMENTS Subcellular localization image for NAPSA gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18216060
GO:0005764 lysosome IDA 14766755
GO:0070062 extracellular exosome IDA 19056867
GO:0097208 alveolar lamellar body IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

Pathways for NAPSA Gene

genes like me logo Genes that share pathways with NAPSA: view

Pathways by source for NAPSA Gene

Interacting Proteins for NAPSA Gene

Gene Ontology (GO) - Biological Process for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 9877162
GO:0033619 membrane protein proteolysis IDA 14766755
GO:0043129 surfactant homeostasis IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

Transcripts for NAPSA Gene

Unigene Clusters for NAPSA Gene

Napsin A aspartic peptidase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPSA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NAPSA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for NAPSA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAPSA Gene

mRNA expression in normal human tissues for NAPSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAPSA Gene

This gene is overexpressed in Lung (39.1) and Kidney - Cortex (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NAPSA Gene

SOURCE GeneReport for Unigene cluster for NAPSA Gene Hs.512843

mRNA Expression by UniProt/SwissProt for NAPSA Gene

Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes
genes like me logo Genes that share expressions with NAPSA: view

In Situ Assay Products

Orthologs for NAPSA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPSA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAPSA 35
  • 99.29 (n)
  • 98.57 (a)
  • 99 (a)
(Bos Taurus)
Mammalia NAPSA 35
  • 85.12 (n)
  • 80.94 (a)
  • 77 (a)
(Canis familiaris)
Mammalia NAPSA 35
  • 84.41 (n)
  • 79.35 (a)
  • 77 (a)
(Mus musculus)
Mammalia Napsa 35
  • 78.45 (n)
  • 72.18 (a)
Napsa 16
Napsa 36
  • 70 (a)
(Monodelphis domestica)
Mammalia NAPSA 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NAPSA 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Napsa 35
  • 78.56 (n)
  • 71.86 (a)
(Gallus gallus)
Aves -- 36
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 39 (a)
(Danio rerio)
Actinopterygii NAPSA 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta cathD 36
  • 48 (a)
CG10104 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea asp-4 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8194 36
  • 45 (a)
Species with no ortholog for NAPSA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAPSA Gene

Gene Tree for NAPSA (if available)
Gene Tree for NAPSA (if available)

Paralogs for NAPSA Gene

Paralogs for NAPSA Gene

Selected SIMAP similar genes for NAPSA Gene using alignment to 2 proteins: Pseudogenes for NAPSA Gene

genes like me logo Genes that share paralogs with NAPSA: view

Variants for NAPSA Gene

Sequence variations from dbSNP and Humsavar for NAPSA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs599100 -- 50,364,472(+) tagcc(A/G)ggcgt intron-variant
rs634713 -- 50,359,928(-) CTGGC(A/G)ATACC intron-variant
rs638294 -- 50,359,766(-) GTCCC(C/T)GCCTA synonymous-codon, reference
rs676314 - 50,362,278(-) CAGGA(C/T)CCTGA missense, reference
rs873834 -- 50,365,745(-) GTCAC(C/T)TGCGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAPSA Gene

Variant ID Type Subtype PubMed ID
dgv3976n71 CNV Loss 21882294
nsv2529 CNV Insertion 18451855
nsv912281 CNV Loss 21882294
nsv912282 CNV Loss 21882294

Relevant External Links for NAPSA Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPSA Gene

Disorders for NAPSA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NAPSA Gene including...

Search for NAPSA Gene in MalaCards »

(2) University of Copenhagen DISEASES for NAPSA Gene

(7) Novoseek inferred disease relationships for NAPSA Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma lung 75.5 11
lung carcinoma 67.8 3
adenocarcinoma 51.5 16
carcinoma renal cell 38.6 3
metastasis 31.4 3
genes like me logo Genes that share disorders with NAPSA: view

No data available for UniProtKB/Swiss-Prot for NAPSA Gene

Publications for NAPSA Gene

  1. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. (PMID: 10580105) Chuman Y. … Linder S. (FEBS Lett. 1999) 3 4 23
  2. Human napsin A: expression, immunochemical detection, and tissue localization. (PMID: 10580106) Schauer-Vukasinovic V. … Giller T. (FEBS Lett. 1999) 3 23
  3. Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. (PMID: 12698189) Ueno T. … Elmberger G. (Br. J. Cancer 2003) 3 23
  4. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. (PMID: 13129928) Brasch F. … Buhling F. (J. Biol. Chem. 2003) 3 23
  5. Napsins: new human aspartic proteinases. Distinction between two closely related genes. (PMID: 9877162) Tatnell P.J. … Kay J. (FEBS Lett. 1998) 3 4

Products for NAPSA Gene

Sources for NAPSA Gene

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