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Aliases for NAPSA Gene

Aliases for NAPSA Gene

  • Napsin A Aspartic Peptidase 2 3 5
  • Kidney-Derived Aspartic Protease-Like Protein 2 3
  • Aspartyl Protease 4 3 4
  • TA01/TA02 3 4
  • Napsin-1 3 4
  • Asp 4 3 4
  • NAP1 3 4
  • ASP4 3 4
  • NAPA 3 4
  • EC 61
  • Pronapsin A 3
  • EC 61
  • EC 61
  • EC 3.4.23.- 4
  • EC 3.4.23 61
  • Napsin-A 3
  • SNAPA 3
  • KDAP 3
  • KAP 3

External Ids for NAPSA Gene

Previous GeneCards Identifiers for NAPSA Gene

  • GC19M055554
  • GC19M055555
  • GC19M050861
  • GC19M047199
  • GC19M050366
  • GC19M050367
  • GC19M050368
  • GC19M050369
  • GC19M050370

Summaries for NAPSA Gene

Entrez Gene Summary for NAPSA Gene

  • This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma. [provided by RefSeq, Feb 2016]

GeneCards Summary for NAPSA Gene

NAPSA (Napsin A Aspartic Peptidase) is a Protein Coding gene. Diseases associated with NAPSA include Ovarian Clear Cell Adenofibroma and Krukenberg Carcinoma. Among its related pathways are Metabolism of proteins and Surfactant metabolism. GO annotations related to this gene include peptidase activity and aspartic-type endopeptidase activity. An important paralog of this gene is CTSD.

UniProtKB/Swiss-Prot for NAPSA Gene

  • May be involved in processing of pneumocyte surfactant precursors.

Gene Wiki entry for NAPSA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPSA Gene

Genomics for NAPSA Gene

Regulatory Elements for NAPSA Gene

Enhancers for NAPSA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G050346 1.2 Ensembl ENCODE 12.8 +21.3 21302 3.9 PKNOX1 ATF1 FOXA2 ARID4B DMAP1 ZNF48 ZNF143 JUNB MIER2 TBX21 NAPSB KCNC3 NAPSA POLD1 JOSD2 ASPDH EMC10 FAM71E1 KLK2 ENSG00000269392
GH19G050479 1.1 ENCODE dbSUPER 11.8 -110.2 -110180 0.7 ELF3 HDGF PKNOX1 CBX3 RB1 ARID4B SIN3A RAD21 ZNF2 ZNF48 NAPSA NR1H2 CLEC11A LOC100506114 FAM71E1 GC19P050481
GH19G050537 1.2 ENCODE dbSUPER 10.7 -168.5 -168548 0.1 SIN3A ZNF2 ZNF48 ZNF143 KLF13 REST ZNF592 ZNF579 MEF2D SMARCA4 ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
GH19G050538 0.9 dbSUPER 10.7 -168.1 -168108 0.7 HDAC1 PTBP1 RB1 ZSCAN4 SIN3A ZNF2 THRB RAD21 ZEB1 ZNF143 ASPDH JOSD2 LRRC4B GPR32 SNORD88A SNORD88B SNORD88C NAPSA NR1H2 C19orf48
GH19G050410 0.7 ENCODE 12.4 -41.6 -41620 1.3 CTCF CHD4 ZMYM3 ZNF384 ZNF488 ZNF48 TBX3 ZNF366 POLR2A SMARCA4 NAPSB NAPSA NR1H2 EMC10 FAM71E1 ENSG00000142539 GC19P050397
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAPSA on UCSC Golden Path with GeneCards custom track

Promoters for NAPSA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111054 231 1001 ARNT SIN3A ZNF2 ZNF48 YY1 ZNF143 ZNF207 REST KAT8 SMARCA4

Genomic Location for NAPSA Gene

50,358,472 bp from pter
50,369,331 bp from pter
10,860 bases
Minus strand

Genomic View for NAPSA Gene

Genes around NAPSA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPSA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPSA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPSA Gene

Proteins for NAPSA Gene

  • Protein details for NAPSA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8WWD9

    Protein attributes for NAPSA Gene

    420 amino acids
    Molecular mass:
    45387 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NAPSA Gene

Selected DME Specific Peptides for NAPSA Gene


Post-translational modifications for NAPSA Gene

  • Glycosylation at Asn90, posLast=133133, and Asn336
  • Modification sites at PhosphoSitePlus

Other Protein References for NAPSA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NAPSA (NAPSA)

Domains & Families for NAPSA Gene

Suggested Antigen Peptide Sequences for NAPSA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase A1 family.
  • Belongs to the peptidase A1 family.
genes like me logo Genes that share domains with NAPSA: view

No data available for Gene Families for NAPSA Gene

Function for NAPSA Gene

Molecular function for NAPSA Gene

UniProtKB/Swiss-Prot Function:
May be involved in processing of pneumocyte surfactant precursors.

Enzyme Numbers (IUBMB) for NAPSA Gene

Gene Ontology (GO) - Molecular Function for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 14766755
GO:0004190 aspartic-type endopeptidase activity NAS,IEA 9877162
GO:0008233 peptidase activity TAS,IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NAPSA: view
genes like me logo Genes that share phenotypes with NAPSA: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NAPSA

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NAPSA Gene

Localization for NAPSA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPSA Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPSA gene
Compartment Confidence
extracellular 5
lysosome 5
endosome 4
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 18216060
GO:0005764 lysosome IDA 14766755
GO:0070062 extracellular exosome IDA 19056867
GO:0097208 alveolar lamellar body IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

Pathways & Interactions for NAPSA Gene

genes like me logo Genes that share pathways with NAPSA: view

Pathways by source for NAPSA Gene

2 Reactome pathways for NAPSA Gene
1 KEGG pathway for NAPSA Gene

Gene Ontology (GO) - Biological Process for NAPSA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS,IEA 9877162
GO:0006914 autophagy IBA --
GO:0030163 protein catabolic process IBA --
GO:0033619 membrane protein proteolysis IDA 14766755
GO:0043129 surfactant homeostasis IDA 18216060
genes like me logo Genes that share ontologies with NAPSA: view

No data available for SIGNOR curated interactions for NAPSA Gene

Drugs & Compounds for NAPSA Gene

(1) Drugs for NAPSA Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pepstatin A Pharma Aspartic proteinases inhibitor 0

(1) ApexBio Compounds for NAPSA Gene

Compound Action Cas Number
Pepstatin A Aspartic proteinases inhibitor 26305-03-3
genes like me logo Genes that share compounds with NAPSA: view

Drug Products

Transcripts for NAPSA Gene

Unigene Clusters for NAPSA Gene

Napsin A aspartic peptidase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPSA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - -

Relevant External Links for NAPSA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAPSA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPSA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAPSA Gene

This gene is overexpressed in Lung (x39.1) and Kidney - Cortex (x9.7).

Protein differential expression in normal tissues from HIPED for NAPSA Gene

This gene is overexpressed in Urine (42.8) and Lung (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAPSA Gene

NURSA nuclear receptor signaling pathways regulating expression of NAPSA Gene:


SOURCE GeneReport for Unigene cluster for NAPSA Gene:


mRNA Expression by UniProt/SwissProt for NAPSA Gene:

Tissue specificity: Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for NAPSA Gene

  • Lung(4.8)
  • Kidney(4.5)
  • Liver(4)
genes like me logo Genes that share expression patterns with NAPSA: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPSA Gene

Orthologs for NAPSA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPSA Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NAPSA 34 35
  • 99.29 (n)
(Bos Taurus)
Mammalia NAPSA 34 35
  • 85.12 (n)
(Canis familiaris)
Mammalia NAPSA 34 35
  • 84.41 (n)
(Rattus norvegicus)
Mammalia Napsa 34
  • 78.56 (n)
(Mus musculus)
Mammalia Napsa 34 16 35
  • 78.45 (n)
(Monodelphis domestica)
Mammalia NAPSA 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia NAPSA 35
  • 55 (a)
(Gallus gallus)
Aves -- 35
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 39 (a)
(Danio rerio)
Actinopterygii NAPSA 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta cathD 35
  • 48 (a)
CG10104 35
  • 41 (a)
(Caenorhabditis elegans)
Secernentea asp-4 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PEP4 35
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8194 35
  • 45 (a)
Species where no ortholog for NAPSA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NAPSA Gene

Gene Tree for NAPSA (if available)
Gene Tree for NAPSA (if available)

Paralogs for NAPSA Gene

Paralogs for NAPSA Gene

(7) SIMAP similar genes for NAPSA Gene using alignment to 2 proteins: Pseudogenes for NAPSA Gene

genes like me logo Genes that share paralogs with NAPSA: view

Variants for NAPSA Gene

Sequence variations from dbSNP and Humsavar for NAPSA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000184052 -- 50,360,406(+) TAGGA(C/T)TTTCT intron-variant
rs1000219894 -- 50,370,604(+) AGTAG(C/G)TGGGA intron-variant, upstream-variant-2KB
rs1000481143 -- 50,366,500(+) CAGCT(A/T)TTTTA intron-variant, upstream-variant-2KB
rs1001187549 -- 50,359,257(+) CTTAC(A/G)CAGTC intron-variant
rs1001782738 -- 50,370,071(+) CGCCA(C/T)CCCAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAPSA Gene

Variant ID Type Subtype PubMed ID
nsv1066389 CNV gain 25217958
nsv1133010 OTHER inversion 24896259
nsv1140251 OTHER inversion 24896259
nsv1152956 OTHER inversion 26484159
nsv2529 CNV insertion 18451855

Variation tolerance for NAPSA Gene

Residual Variation Intolerance Score: 80.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPSA Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPSA Gene

Disorders for NAPSA Gene

MalaCards: The human disease database

(17) MalaCards diseases for NAPSA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian clear cell adenofibroma
krukenberg carcinoma
  • krukenberg neoplasm
lung cancer susceptibility 3
  • lung adenocarcinoma
ovarian clear cell carcinoma
  • clear-cell ovarian carcinoma
sarcomatoid mesothelioma
  • malignant fibrous mesothelioma
- elite association - COSMIC cancer census association via MalaCards
Search NAPSA in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAPSA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NAPSA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPSA Gene

Publications for NAPSA Gene

  1. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. (PMID: 10580105) Chuman Y. … Linder S. (FEBS Lett. 1999) 3 4 22 64
  2. Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma. (PMID: 19740516) Bishop J.A. … Illei P.B. (Hum. Pathol. 2010) 3 22 64
  3. The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. (PMID: 18195689) Ueno T. … Linder S. (Lab. Invest. 2008) 3 22 64
  4. Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis. (PMID: 18216060) Woischnik M. … Griese M. (Eur. Respir. J. 2008) 3 22 64
  5. Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma. (PMID: 12698189) Ueno T. … Elmberger G. (Br. J. Cancer 2003) 3 22 64

Products for NAPSA Gene

Sources for NAPSA Gene

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