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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NAPRT1 Gene

protein-coding GIFtS: 55
GCID: GC08M144656

nicotinate phosphoribosyltransferase domain containing 1

Explore 6 diseases affiliated with
NAPRT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nicotinate Phosphoribosyltransferase Domain Containing 1¹ ²		EC 2.4.2.11³ ⁸
PP3856¹ ²		Nicotinate Phosphoribosyltransferase²
Nicotinate Phosphoribosyltransferase Domain-Containing Protein 1² ³		Nicotinic Acid Phosphoribosyltransferase²
NAPRTase² ³		FHIP³
FHA-HIT-Interacting Protein² ³

External Ids:	HGNC: 30450¹	Entrez Gene: 93100²	Ensembl: ENSG00000147813⁷	OMIM: 611552⁵	UniProtKB: Q6XQN6³

Export aliases for NAPRT1 gene to outside databases

Previous GC identifers: GC08M144730 GC08M139908

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAPRT1:

Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA

mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine

dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety

of processes in cellular metabolism including response to stress (Hara et al., 2007).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6

Function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase

cellular NAD levels and prevent oxidative stress of the cells

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NAPRT1 gene promoter:
NF-1/L NF-1 Elk-1 GCNF AP-4 HNF-4alpha1 YY1 CP2 E2F E2F-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAPRT1 promoter sequence

Search SABiosciences Chromatin IP Primers for NAPRT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPRT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3

NAPRT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPRT1 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M144656: view genomic region (about GC identifiers)

Start:	144,656,955 bp from pter	End:	144,660,819 bp from pter
Size:	3,865 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6 (See protein sequence)

Recommended Name: Nicotinate phosphoribosyltransferase

Size: 538 amino acids; 57578 Da

Subcellular location: Cytoplasm, cytosol

Sequence caution: Sequence=AAH06284.2; Type=Erroneous initiation; Sequence=AAH32466.1; Type=Erroneous initiation;

Secondary accessions: A7BFI3 Q6PJL1 Q6XQN4 Q6XQN5 Q8N5E8 Q9BRG0

Alternative splicing: 3 isoforms: Q6XQN6-1 Q6XQN6-2 Q6XQN6-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NAPRT1: NX_Q6XQN6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6XQN6

3 DME Specific Peptides for NAPRT1 (Q6XQN6)

LQLAEEP

GLRRAQGP

AVGVRLDSGDLLQQA

NAPRT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_660202.3

ENSEMBL proteins:

ENSP00000405670 ENSP00000401508 ENSP00000341136 ENSP00000390949 ENSP00000437102

ENSP00000433245 ENSP00000276844

Reactome Protein details: Q6XQN6
Human Recombinant Protein Products for NAPRT1:

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	Novus Biologicals NAPRT1 Protein Novus Biologicals NAPRT1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NAPRT1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005794	Golgi apparatus	IDA	--
GO:0005829	cytosol	TAS	--

NAPRT1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NAPRT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NAPRT1 for domains About GeneDecksing

4 InterPro domains/families:

IPR002638 Quinolinate_PRibosylTrfase_C

IPR007229 Nic_PRibTrfase-rel

IPR006405 Nic_PRibTrfase_put

IPR015977 Nic_PRibTrfase-like

Graphical View of Domain Structure for InterPro Entry Q6XQN6

ProtoNet protein and cluster: Q6XQN6

1 Blocks protein family: IPB007229 Nicotinate phosphoribosyltransferase and related

UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6

Similarity: Belongs to the NAPRTase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: PNCB_HUMAN, Q6XQN6

Function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase

cellular NAD levels and prevent oxidative stress of the cells

Catalytic activity: Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose

1-diphosphate

Enzyme Number (IUBMB): EC 2.4.2.11¹ ²

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA	--
GO:0004516	nicotinate phosphoribosyltransferase activity	TAS	--

NAPRT1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NAPRT1:

Increased HPV18 LCR reporter a

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NAPRT1

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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAPRT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAPRT1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPRT1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Vitamin B5 (pantothenate) metabolism

Metabolism of vitamins and cofactors

0.21

Metabolism of water-soluble vitamins and cofactors

0.21

Nicotinamide salvaging

Nicotinamide salvaging

1.00

Nicotinate metabolism

Nicotinate metabolism

1.00

NAD metabolism

Nicotinate and nicotinamide metabolism

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

5 Reactome Pathways for NAPRT1

	Nicotinamide salvaging
	Nicotinate metabolism
	Metabolism
	Metabolism of vitamins and cofactors
	Metabolism of water-soluble vitamins and cofactors

2 Kegg Pathways (Kegg details for NAPRT1):

	Nicotinate and nicotinamide metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6

Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1

NAPRT1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NAPRT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/19 Interacting proteins for NAPRT1 (Q6XQN6³ ENSP00000401508⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 19)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RBL1	P28749³	I2D: score=1
NMNAT1	ENSP00000366410⁴	STRING: ENSP00000366410
NMNAT2	ENSP00000287713⁴	STRING: ENSP00000287713
NMNAT3	ENSP00000340523⁴	STRING: ENSP00000340523
NUDT12	ENSP00000230792⁴	STRING: ENSP00000230792

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006766	vitamin metabolic process	TAS	--
GO:0006767	water-soluble vitamin metabolic process	TAS	--
GO:0006769	nicotinamide metabolic process	TAS	--
GO:0006979	response to oxidative stress	IMP	17604275
GO:0009435	NAD biosynthetic process	IEA	--

NAPRT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NAPRT1

2 HMDB Compounds for NAPRT1 About this table

Compound	Synonyms	CAS #	PubMed Ids
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
Nicotinic acid mononucleotide	3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt (see all 23)	321-02-8	--

Search CenterWatch for drugs/clinical trials and news about NAPRT1 / PNCB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NAPRT1 gene:

NM_145201.4

Unigene Cluster for NAPRT1:

Nicotinate phosphoribosyltransferase domain containing 1

Hs.493164 [show with all ESTs]

Unigene Representative Sequence: AY214325

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000529179 ENST00000460623 ENST00000435154(uc003yyn.4 uc011lkh.2 uc003yyo.4)

ENST00000449291(uc003yym.4) ENST00000498076 ENST00000464332 ENST00000340490

ENST00000426292 ENST00000525583 ENST00000488096 ENST00000532645 ENST00000480946

ENST00000491904 ENST00000462059 ENST00000276844

miRNA Products:		OriGene 3'-UTR Clone: NAPRT1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAPRT1
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against NAPRT1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAPRT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAPRT1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AB242230.1 AF258565.1 AK097002.1 AY214325.1 AY214326.1 AY214327.1 BC006284.2 BC032466.1

14 DOTS entries:

DT.95293101 DT.97813675 DT.75101665 DT.100751570 DT.100682281 DT.75101664 DT.120634731 DT.412214

DT.95120888 DT.100751572 DT.120634822 DT.92058858 DT.95213902 DT.97813644

22 AceView cDNA sequences:

AW751138 BM818808 BG824256 BG746868 CR592925 AW516824 CR591708 BM768570

BM826760 BC006284 CA407797 AW806779 AW806800 AI871064 BG746945 AI458775

BM818957 AI476528 AW806799 CD671444 AW806801 NM_145201

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAPRT1 (see all 10) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13	^	14a	·	14b
SP1:							-														-																		-
SP2:							-														-
SP3:							-														-
SP4:							-														-
SP5:

ECgene alternative splicing isoforms for NAPRT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NAPRT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCAGTTAG

About this image

NAPRT1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NAPRT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAPRT1

SOURCE GeneReport for Unigene cluster: Hs.493164

SABiosciences Custom PCR Arrays for NAPRT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAPRT1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPRT1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPRT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAPRT1 gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Naprt1^{1 , 5}	nicotinate phosphoribosyltransferase domain containing more^{1, 5}	81.96(n)¹ 84.46(a)¹		15 (35.05 cM)⁵ 223646¹ NM_172607.3¹ NP_766195.2¹ 75890964⁵
chicken (Gallus gallus)	Aves	NAPRT1⁶	nicotinate phosphoribosyltransferase domain contai...	56(a)	1 ↔ 1	2(154533071-154538627)
lizard (Anolis carolinensis)	Reptilia	-- --	--	57(a) 52(a)	many → 1 many → 1	GL343511.1(23715-56478) GL345033.1(1-11972)
zebrafish (Danio rerio)	Actinopterygii	naprt1¹	nicotinate phosphoribosyltransferase domain containing more	58.33(n) 56.05(a)		393864 NM_200890.1 NP_957184.1
fruit fly (Drosophila melanogaster)	Insecta	CG3714⁶	--	36(a)	1 ↔ 1	2L(4189497-4198058)
worm (Caenorhabditis elegans)	Secernentea	Y54G2A.17⁶	Nicotinate phosphoribosyltransferase	41(a)	1 ↔ 1	IV(2872217-2890447)
thale cress (Arabidopsis thaliana)	eudicotyledons	NAPRT1⁶ NAPRT2⁶	nicotinate phosphoribosyltransferase	43(a) 43(a)	many → 1 many → 1	4(17416855-17420252) 2(9971701-9975192)
rice (Oryza sativa)	Liliopsida	-- --	nicotinate phosphoribosyltransferase family domain... nicotinate phosphoribosyltransferase family domain...	44(a) 43(a)	many → 1 many → 1	3(35183664-35190433) 4(21138484-21146301)

ENSEMBL Gene Tree for NAPRT1 (if available)
TreeFam Gene Tree for NAPRT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72691478^1,2	C	--	144656732(+)	`TAGTGG/TGGGAT`	2	--	us2k¹ int¹		0	--	--	--	--
rs4606077^1,2	C,F,A,H	--	144656754(+)	`CAGCCC/TACCCA`	2	--	us2k¹ int¹		26		NS EA NA WA CSA	2351
rs58774517^1,2	C	--	144656764(+)	`AAAGCC/TGGGGA`	2	--	us2k¹ int¹		3		NA EA	242
rs1869434^1,2	C,F,A,H	--	144656765(-)	`TTCCCT/CGGCTT`	2	--	int¹ us2k¹		13		NA WA CSA EA	377
rs191092724^1,2		--	144656898(+)	`CAGCCC/TGGGAG`	2	--	us2k¹ int¹		0	--	--	--	--
rs78452615^1,2	C,F	--	144656977(+)	`GATTCG/CTGTTG`	1	--	ut3¹		3		WA NA EU	814
rs184508642^1,2		--	144656998(+)	`GCCCCA/GCTCCG`	1	--	ut3¹		0	--	--	--	--
rs190345767^1,2		--	144657002(+)	`CGCTCC/TGAGTC`	1	--	ut3¹		0	--	--	--	--
rs115590341^1,2	F	--	144657123(+)	`CGCACA/GGGGCA`	1	--	int¹		1		WA	118
rs77951814^1,2	C	--	144657152(+)	`CCCCCC/GAACCT`	1	--	int¹		3		NA EA	242

HapMap Linkage Disequilibrium report for NAPRT1 (144656955 - 144660819 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for NAPRT1
6 CNVs: 4612 52423 30302 52421 30297 52422
Human Gene Mutation Database (HGMD): NAPRT1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NAPRT1 for disorders           About GeneDecksing

OMIM gene information: 611552    OMIM disorders: --

6 diseases for NAPRT1:    About MalaCards

attention deficit hyperactivity disorder pellagra pneumonia tuberculosis

malaria mycobacterium tuberculosis

Export disorders for NAPRT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NAPRT1 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NAPRT1)

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Elevation of Cellular NAD Levels by Nicotinic Acid and Involvement of Nicotinic Acid Phosphoribosyltransferase in Human Cells. (PubMed id 17604275)^{1, 2} Hara N.... Tsuchiya M. (2007)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Inhibition of nicotinamide phosphoribosyltransferase ( NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS )-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. (PubMed id 22570471)¹ Cerna D....Yoo S.S. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Expression patterns of nicotinamide phosphoribosyltra nsferase and nicotinic acid phosphoribosyltransferase in human malignant lympho mas. (PubMed id 21492230)¹ Olesen U.H....Sehested M. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 93100	HGNC: 30450	AceView: PP3856	Ensembl:ENSG00000147813	euGenes: HUgn93100
ECgene: NAPRT1	Kegg: 93100	H-InvDB: NAPRT1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NAPRT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NAPRT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NAPRT1 gene:
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GeneCards and IP:
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nicotinate phosphoribosyltransferase domain containing 1

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nicotinate phosphoribosyltransferase domain containing 1

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