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Aliases & Descriptions for NAPRT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.4.2.11 3 | | FHIP 3 | | NAPRTase 3 | | PP3856 1, 2 |
| | | Descriptions |
|---|
| FHA-HIT-interacting protein 3 | Nicotinate phosphoribosyltransferase domain-containing protein 1 3 | | nicotinate phosphoribosyltransferase domain containing 1 2 | | nicotinic acid phosphoribosyltransferase 2 |
|
| | Search outside databases for aliases for NAPRT1 gene |
Summaries for NAPRT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAPRT1: Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM] UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6Function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells |
Genomic Location for NAPRT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAPRT1 gene 
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3NAPRT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M144730:
(about GC identifiers)
Start:
|
144,728,098 bp from pter |
End:
|
144,731,651 bp from pter |
Size:
|
3,554 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000008.9 NT_023684.17
| Proteins for NAPRT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6 (See
protein sequence)Recommended Name: Nicotinate phosphoribosyltransferase Size: 538 amino acids; 57578 Da
Subcellular location: Cytoplasm, cytosol
Secondary accessions: A7BFI3 Q6PJL1 Q6XQN4 Q6XQN5 Q8N5E8 Q9BRG0Alternative splicing: 4 isoforms: Q6XQN6-1 Q6XQN6-2 Q6XQN6-3 Q6XQN6-4 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_660202.3
ENSEMBL proteins: ENSP00000341136 ENSP00000276844
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NAPRT1: Assays for NAPRT1: | Protein
Domains/ Families for NAPRT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6XQN6
ProtoNet protein and cluster: Q6XQN6 1 Blocks protein family: IPB007229 Nicotinate phosphoribosyltransferase and related
UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6Similarity: Belongs to the NAPRTase family | Gene Function for NAPRT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145201
Applied Biosystems Silencer® siRNAs for NAPRT1
Sigma-Aldrich siRNA for NAPRT1  Sigma-Aldrich shRNA for NAPRT1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145201                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145201                                  untagged cDNA clones in CMV expression vector (see all 2): AK097002 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_145201
UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6Function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cellsCatalytic activity: Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphateEnzyme Number (IUBMB): EC 2.4.2.11 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004516 | nicotinate phosphoribosyltransferase activity |
IDA | 17604275 | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- | About this table | Pathways & Interactions for NAPRT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for NAPRT1 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: PNCB_HUMAN, Q6XQN6Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate ribonucleotide from nicotinate: step 1/1 2 Interacting proteins for NAPRT1 (ENSP000002768443) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006979 | response to oxidative stress |
IMP | 17604275 | | GO:0019363 | pyridine nucleotide biosynthetic process |
IEA | -- | About this table
|
Drugs & Compounds for NAPRT1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAPRT1
|
Transcripts for NAPRT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145201
Sigma-Aldrich siRNA for NAPRT1  Sigma-Aldrich shRNA for NAPRT1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_145201 REFSEQ mRNAs for NAPRT1 gene: NM_145201.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_145201               OriGene GFP tagged cDNA clone in CMV expression vector: NM_145201                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_145201                                  untagged cDNA clones in CMV expression vector (see all 2): AK097002  Additional cDNA sequence: AB242230.1 AF258565.1 AK097002.1 AY214325.1 AY214326.1 AY214327.1 BC006284.2 BC032466.1 CR591708.1 CR592925.1 14 DOTS entries: DT.95293101 DT.97813675 DT.75101665 DT.100751570 DT.100682281 DT.75101664 DT.120634731 DT.412214 DT.95120888 DT.100751572 DT.120634822 DT.92058858 DT.95213902 DT.97813644 22 AceView cDNA sequences:AW806799 BM826760 CA407797 AW806800 AI458775 CR591708 AW806801 AI476528 CR592925 BM818808 AW751138 BC006284 AW516824 AI871064 BG746945 CD671444 BM768570 AW806779 BM818957 BG824256 BG746868 NM_145201
highest scoring ESTs for NAPRT1:AI871064 AW516824 BC006284 BG746868 BG746945 BG824256 AA621834 AA649311 AI185086 AI431636 Unigene Cluster for NAPRT1: Nicotinate phosphoribosyltransferase domain containing 1 Hs.493164 [show with all ESTs]Unigene Representative Sequence: AY214325
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NAPRT1 (see all 10
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14a | · | 14b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAPRT1
2 Ensembl transcripts including schematic representations: ENST00000340490
ENST00000276844
|
Expression for NAPRT1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAPRT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAPRT1
1 / 2 / 3 4 probe-sets matching NAPRT1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGCAGTTAG
SOURCE GeneReport for Unigene cluster: Hs.493164
|
Orthologs for NAPRT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAPRT1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for NAPRT1
ENSEMBL Gene Tree for NAPRT1 | Paralogs for NAPRT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for NAPRT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAPRT1 (up to first 250kb)
|
Disorders & Mutations for NAPRT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611552
|
Medical News for NAPRT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAPRT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 7 PubMed articles for NAPRT1 gene: |
Search for NAPRT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAPRT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAPRT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAPRT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAPRT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAPRT1:

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| | | | Search Tocris compounds for NAPRT1 |
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Incremental update: 13 Oct 2009
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