Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NAPRT Gene

Aliases for NAPRT Gene

  • Nicotinate Phosphoribosyltransferase 2 3 5
  • Nicotinate Phosphoribosyltransferase Domain-Containing Protein 1 3 4
  • Nicotinate Phosphoribosyltransferase Domain Containing 1 2 3
  • FHA-HIT-Interacting Protein 3 4
  • NAPRTase 3 4
  • NAPRT1 3 4
  • Nicotinic Acid Phosphoribosyltransferase 3
  • EC 2.4.2.11 61
  • EC 6.3.4.21 4
  • PP3856 3
  • FHIP 4

External Ids for NAPRT Gene

Previous HGNC Symbols for NAPRT Gene

  • NAPRT1

Summaries for NAPRT Gene

Entrez Gene Summary for NAPRT Gene

  • Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]

GeneCards Summary for NAPRT Gene

NAPRT (Nicotinate Phosphoribosyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include ligase activity and nicotinate phosphoribosyltransferase activity.

UniProtKB/Swiss-Prot for NAPRT Gene

  • Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.

  • Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPRT Gene

Genomics for NAPRT Gene

Regulatory Elements for NAPRT Gene

Enhancers for NAPRT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143601 1.3 FANTOM5 ENCODE 60 -22.6 -22624 2.0 PKNOX1 ARID4B SIN3A GLIS2 DEK SP3 MXD4 ZHX2 REST ZNF592 NAPRT LOC105375798 GSDMD SLC39A4 EEF1D PYCRL
GH08F143595 1.1 ENCODE 59.9 -18.3 -18306 5.1 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 NAPRT C8orf82 GSDMD ZNF623 VPS28 AK3P2 LOC105375798 EEF1D TIGD5
GH08F143576 1 ENCODE 46.1 +1.3 1270 4.0 ATF1 SIN3A ZNF2 YY1 ZNF121 GLIS2 KLF7 DEK REST SMARCA4 NAPRT GSDMD LRRC14 LOC105375803 JRK ZNF696 ZNF623 CYHR1 VPS28 SLC39A4
GH08F143607 1.1 ENCODE 37.2 -30.0 -29996 3.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 NAPRT LOC105375798 ENSG00000255050 TOP1MT GSDMD SLC39A4 PYCRL EEF1D
GH08F143570 1 ENCODE 29.9 +6.3 6332 4.6 ATF1 PKNOX1 ZNF133 ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2 GLIS2 NAPRT GSDMD ZNF623 VPS28 AK3P2 MROH6 ENSG00000255050
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAPRT on UCSC Golden Path with GeneCards custom track

Promoters for NAPRT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404175 1526 1401 ATF1 SIN3A ZNF2 YY1 ZNF121 GLIS2 KLF7 DEK REST ZNF610

Genomic Location for NAPRT Gene

Chromosome:
8
Start:
143,574,664 bp from pter
End:
143,579,626 bp from pter
Size:
4,963 bases
Orientation:
Minus strand

Genomic View for NAPRT Gene

Genes around NAPRT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPRT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPRT Gene

Proteins for NAPRT Gene

  • Protein details for NAPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XQN6-PNCB_HUMAN
    Recommended name:
    Nicotinate phosphoribosyltransferase
    Protein Accession:
    Q6XQN6
    Secondary Accessions:
    • A7BFI3
    • Q6PJL1
    • Q6XQN4
    • Q6XQN5
    • Q8N5E8
    • Q9BRG0

    Protein attributes for NAPRT Gene

    Size:
    538 amino acids
    Molecular mass:
    57578 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06284.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH32466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAPRT Gene

    Alternative splice isoforms for NAPRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAPRT Gene

Selected DME Specific Peptides for NAPRT Gene

Q6XQN6:
  • AVGVRLDSGDLLQQA
  • GLRRAQGP
  • LQLAEEP

Post-translational modifications for NAPRT Gene

  • Ubiquitination at Lys 396, Lys 407, and Lys 421
  • Modification sites at PhosphoSitePlus

Domains & Families for NAPRT Gene

Suggested Antigen Peptide Sequences for NAPRT Gene

Graphical View of Domain Structure for InterPro Entry

Q6XQN6

UniProtKB/Swiss-Prot:

PNCB_HUMAN :
  • Belongs to the NAPRTase family.
Family:
  • Belongs to the NAPRTase family.
genes like me logo Genes that share domains with NAPRT: view

No data available for Gene Families for NAPRT Gene

Function for NAPRT Gene

Molecular function for NAPRT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=44.3 uM for nicotinic acid (in the presence of 3 mM ATP) {ECO:0000269 PubMed:21742010}; KM=22.1 uM for 5-phosphoribosyl-1-pyrophosphate (in the presence of 3 mM ATP) {ECO:0000269 PubMed:21742010}; KM=27.3 uM for nicotinic acid (in the presence of inorganic phosphate) {ECO:0000269 PubMed:21742010}; KM=38.2 uM for 5-phosphoribosyl-1-pyrophosphate (in the presence of inorganic phosphate) {ECO:0000269 PubMed:21742010};
UniProtKB/Swiss-Prot CatalyticActivity:
Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.
UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

Enzyme Numbers (IUBMB) for NAPRT Gene

Gene Ontology (GO) - Molecular Function for NAPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA --
GO:0004516 nicotinate phosphoribosyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with NAPRT: view
genes like me logo Genes that share phenotypes with NAPRT: view

Animal Model Products

miRNA for NAPRT Gene

miRTarBase miRNAs that target NAPRT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPRT Gene

Localization for NAPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPRT Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPRT gene
Compartment Confidence
extracellular 5
cytosol 5
lysosome 4
nucleus 3
golgi apparatus 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for NAPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAPRT: view

Pathways & Interactions for NAPRT Gene

genes like me logo Genes that share pathways with NAPRT: view

UniProtKB/Swiss-Prot Q6XQN6-PNCB_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.

Gene Ontology (GO) - Biological Process for NAPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006769 nicotinamide metabolic process TAS --
GO:0006979 response to oxidative stress IMP 17604275
GO:0009435 NAD biosynthetic process IEA --
GO:0019358 nicotinate nucleotide salvage IEA --
GO:0019363 pyridine nucleotide biosynthetic process IEA --
genes like me logo Genes that share ontologies with NAPRT: view

No data available for SIGNOR curated interactions for NAPRT Gene

Drugs & Compounds for NAPRT Gene

(3) Drugs for NAPRT Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist 906,906
GNE-617 Pharma NAMPT inhibitor 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for NAPRT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nicotinate beta-D-ribonucleotide
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
321-02-8
Phosphoribosyl pyrophosphate
  • 5-Phospho-a-D-ribose-1-diphosphate
  • 5-Phospho-a-D-ribosyl pyrophosphate
  • 5-Phospho-alpha-D-ribose 1-diphosphate
  • 5-Phospho-alpha-D-ribose-1-diphosphate
  • 5-Phospho-alpha-D-ribosyl pyrophosphate
7540-64-9
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(1) ApexBio Compounds for NAPRT Gene

Compound Action Cas Number
GNE-617 NAMPT inhibitor 1362154-70-8
genes like me logo Genes that share compounds with NAPRT: view

Transcripts for NAPRT Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPRT Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: - - -
SP10:

Relevant External Links for NAPRT Gene

GeneLoc Exon Structure for
NAPRT
ECgene alternative splicing isoforms for
NAPRT

Expression for NAPRT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NAPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPRT Gene

This gene is overexpressed in Liver, secretome (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAPRT Gene



Protein tissue co-expression partners for NAPRT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAPRT Gene:

NAPRT
genes like me logo Genes that share expression patterns with NAPRT: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPRT Gene

Orthologs for NAPRT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAPRT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPRT1 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia NAPRT1 34 35
  • 86.96 (n)
dog
(Canis familiaris)
Mammalia NAPRT1 34 35
  • 84.42 (n)
mouse
(Mus musculus)
Mammalia Naprt1 34 35
  • 81.96 (n)
Naprt 16
rat
(Rattus norvegicus)
Mammalia Naprt1 34
  • 81.46 (n)
oppossum
(Monodelphis domestica)
Mammalia NAPRT1 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPRT1 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAPRT1 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 58 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naprt1 34
  • 65.44 (n)
zebrafish
(Danio rerio)
Actinopterygii naprt1 34 35
  • 58.62 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008516 34
  • 54.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3714 34 35
  • 53.45 (n)
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.17 34 35
  • 50.06 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NAPRT1 34
  • 49.3 (n)
rice
(Oryza sativa)
Liliopsida Os03g0837300 34
  • 52.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToOne
Species where no ortholog for NAPRT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPRT Gene

ENSEMBL:
Gene Tree for NAPRT (if available)
TreeFam:
Gene Tree for NAPRT (if available)

Paralogs for NAPRT Gene

No data available for Paralogs for NAPRT Gene

Variants for NAPRT Gene

Sequence variations from dbSNP and Humsavar for NAPRT Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090485 -- 143,580,060(+) CCCAC(C/T)TTGTC upstream-variant-2KB, reference, synonymous-codon
rs10095885 -- 143,579,225(+) CCACG(C/T)TCTGG downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1062391 -- 143,580,183(-) ATGGC(C/T)CAGCT upstream-variant-2KB, reference, synonymous-codon
rs1062400 -- 143,580,059(-) ACAAG(A/G)TGGGG upstream-variant-2KB, reference, missense
rs1062401 -- 143,580,058(-) CAAGG(A/T)GGGGA upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NAPRT Gene

Variant ID Type Subtype PubMed ID
nsv950013 CNV deletion 24416366
nsv824770 CNV gain 20364138
nsv612813 CNV loss 21841781
nsv612812 CNV loss 21841781
nsv612793 CNV loss 21841781
nsv612777 CNV gain 21841781
nsv612774 CNV loss 21841781
nsv516210 CNV loss 19592680
nsv470248 CNV gain 18288195
nsv470247 CNV loss 18288195
nsv466000 CNV loss 19166990
nsv1161810 CNV deletion 26073780
nsv1161809 CNV deletion 26073780
nsv1147655 CNV deletion 26484159
esv2738022 CNV deletion 23290073
esv2738021 CNV deletion 23290073
esv2738020 CNV deletion 23290073
dgv7336n100 CNV gain 25217958
dgv12418n54 CNV loss 21841781
dgv12410n54 CNV loss 21841781

Variation tolerance for NAPRT Gene

Residual Variation Intolerance Score: 84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPRT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPRT Gene

Disorders for NAPRT Gene

Relevant External Links for NAPRT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPRT

No disorders were found for NAPRT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPRT Gene

Publications for NAPRT Gene

  1. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site- directed mutagenesis. (PMID: 21742010) Galassi L. … Magni G. (Biochimie 2012) 2 3 4 64
  2. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. (PMID: 17604275) Hara N. … Tsuchiya M. (J. Biol. Chem. 2007) 2 3 4 64
  3. Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. (PMID: 26675378) Duarte-Pereira S. … Silva R.M. (Oncotarget 2016) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for NAPRT Gene

Sources for NAPRT Gene

Content
Loading form....