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Aliases for NAPRT Gene

Aliases for NAPRT Gene

  • Nicotinate Phosphoribosyltransferase 2 3
  • Nicotinate Phosphoribosyltransferase Domain-Containing Protein 1 3 4
  • Nicotinate Phosphoribosyltransferase Domain Containing 1 2 3
  • FHA-HIT-Interacting Protein 3 4
  • NAPRTase 3 4
  • NAPRT1 3 4
  • Nicotinic Acid Phosphoribosyltransferase 3
  • EC 2.4.2.11 63
  • EC 6.3.4.21 4
  • PP3856 3
  • FHIP 4

External Ids for NAPRT Gene

Previous HGNC Symbols for NAPRT Gene

  • NAPRT1

Summaries for NAPRT Gene

Entrez Gene Summary for NAPRT Gene

  • Nicotinic acid (NA; niacin) is converted by nicotinic acid phosphoribosyltransferase (NAPRT; EC 2.4.2.11) to NA mononucleotide (NaMN), which is then converted to NA adenine dinucleotide (NaAD), and finally to nicotinamide adenine dinucleotide (NAD), which serves as a coenzyme in cellular redox reactions and is an essential component of a variety of processes in cellular metabolism including response to stress (Hara et al., 2007).[supplied by OMIM, Mar 2008]

GeneCards Summary for NAPRT Gene

NAPRT (Nicotinate Phosphoribosyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism of vitamins and cofactors. GO annotations related to this gene include ligase activity and nicotinate phosphoribosyltransferase activity.

UniProtKB/Swiss-Prot for NAPRT Gene

  • Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.

  • Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPRT Gene

Genomics for NAPRT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAPRT Gene

Chromosome:
8
Start:
143,574,664 bp from pter
End:
143,579,626 bp from pter
Size:
4,963 bases
Orientation:
Minus strand

Genomic View for NAPRT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPRT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPRT Gene

No data available for Regulatory Elements for NAPRT Gene

Proteins for NAPRT Gene

  • Protein details for NAPRT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XQN6-PNCB_HUMAN
    Recommended name:
    Nicotinate phosphoribosyltransferase
    Protein Accession:
    Q6XQN6
    Secondary Accessions:
    • A7BFI3
    • Q6PJL1
    • Q6XQN4
    • Q6XQN5
    • Q8N5E8
    • Q9BRG0

    Protein attributes for NAPRT Gene

    Size:
    538 amino acids
    Molecular mass:
    57578 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH06284.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH32466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NAPRT Gene

    Alternative splice isoforms for NAPRT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAPRT Gene

Proteomics data for NAPRT Gene at MOPED

Selected DME Specific Peptides for NAPRT Gene

Post-translational modifications for NAPRT Gene

  • Ubiquitination at Lys 396, Lys 407, and Lys 421
  • Modification sites at PhosphoSitePlus

Domains & Families for NAPRT Gene

Suggested Antigen Peptide Sequences for NAPRT Gene

Graphical View of Domain Structure for InterPro Entry

Q6XQN6

UniProtKB/Swiss-Prot:

PNCB_HUMAN :
  • Belongs to the NAPRTase family.
Family:
  • Belongs to the NAPRTase family.
genes like me logo Genes that share domains with NAPRT: view

No data available for Gene Families for NAPRT Gene

Function for NAPRT Gene

Molecular function for NAPRT Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=44.3 uM for nicotinic acid (in the presence of 3mM ATP) {ECO:0000269 PubMed:21742010}; KM=22.1 uM for 5-phosphoribosyl-1-pyrophosphate (in the presence of 3mM ATP) {ECO:0000269 PubMed:21742010}; KM=27.3 uM for nicotinic acid (in the presence of inorganic phosphate) {ECO:0000269 PubMed:21742010}; KM=38.2 uM for 5-phosphoribosyl-1-pyrophosphate (in the presence of inorganic phosphate) {ECO:0000269 PubMed:21742010};
UniProtKB/Swiss-Prot CatalyticActivity:
Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate
UniProtKB/Swiss-Prot Function:
Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells.
UniProtKB/Swiss-Prot Function:
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.

Enzyme Numbers (IUBMB) for NAPRT Gene

Gene Ontology (GO) - Molecular Function for NAPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA --
GO:0004516 nicotinate phosphoribosyltransferase activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with NAPRT: view

Phenotypes for NAPRT Gene

GenomeRNAi human phenotypes for NAPRT:
genes like me logo Genes that share phenotypes with NAPRT: view

miRNA for NAPRT Gene

miRTarBase miRNAs that target NAPRT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPRT

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NAPRT Gene

Localization for NAPRT Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPRT Gene

Cytoplasm, cytosol.

Gene Ontology (GO) - Cellular Components for NAPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NAPRT: view

No data available for Subcellular locations from COMPARTMENTS for NAPRT Gene

Pathways & Interactions for NAPRT Gene

genes like me logo Genes that share pathways with NAPRT: view

UniProtKB/Swiss-Prot Q6XQN6-PNCB_HUMAN

  • Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1

Gene Ontology (GO) - Biological Process for NAPRT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006769 nicotinamide metabolic process TAS --
GO:0006979 response to oxidative stress IMP 17604275
GO:0009435 NAD biosynthetic process IEA --
genes like me logo Genes that share ontologies with NAPRT: view

No data available for SIGNOR curated interactions for NAPRT Gene

Drugs & Compounds for NAPRT Gene

(5) Drugs for NAPRT Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist 340,340
Diphosphate Experimental Pharma 0
Phosphoribosyl pyrophosphate Experimental Pharma 0
GNE-617 Pharma NAMPT inhibitor 0
NAD Pharma Agonist, Activator 0

(2) Additional Compounds for NAPRT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
nicotinate beta-D-ribonucleotide
Nicotinic acid mononucleotide
  • 3-Carboxy-1-(5-O-phosphono-b-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-D-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-(5-O-phosphono-beta-delta-ribofuranosyl)-Pyridinium inner salt
  • 3-Carboxy-1-beta-D-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
  • 3-Carboxy-1-beta-delta-ribofuranosylpyridinium hydroxide 5'-phosphate inner salt
321-02-8
genes like me logo Genes that share compounds with NAPRT: view

Transcripts for NAPRT Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPRT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPRT Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: - - - -
SP7: - - -
SP8: - - -
SP9: - - -
SP10:

Relevant External Links for NAPRT Gene

GeneLoc Exon Structure for
NAPRT
ECgene alternative splicing isoforms for
NAPRT

Expression for NAPRT Gene

mRNA expression in normal human tissues for NAPRT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPRT Gene

This gene is overexpressed in Liver, secretome (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAPRT Gene



genes like me logo Genes that share expression patterns with NAPRT: view

Protein tissue co-expression partners for NAPRT Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPRT Gene

Orthologs for NAPRT Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NAPRT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAPRT1 35
  • 86.96 (n)
  • 89.6 (a)
NAPRT1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPRT1 35
  • 84.42 (n)
  • 86.57 (a)
NAPRT1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Naprt1 35
  • 81.96 (n)
  • 84.46 (a)
Naprt1 16
Naprt1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAPRT1 35
  • 99.16 (n)
  • 99.03 (a)
NAPRT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Naprt1 35
  • 81.46 (n)
  • 81.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NAPRT1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPRT1 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAPRT1 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 58 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia naprt1 35
  • 65.44 (n)
  • 61.01 (a)
zebrafish
(Danio rerio)
Actinopterygii naprt1 35
  • 58.62 (n)
  • 56.7 (a)
naprt1 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008516 35
  • 54.97 (n)
  • 46.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3714 35
  • 53.45 (n)
  • 47.13 (a)
CG3714 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y54G2A.17 35
  • 50.06 (n)
  • 44.47 (a)
Y54G2A.17 36
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons NAPRT1 35
  • 49.3 (n)
  • 46.36 (a)
rice
(Oryza sativa)
Liliopsida Os03g0837300 35
  • 52.62 (n)
  • 48.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for NAPRT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPRT Gene

ENSEMBL:
Gene Tree for NAPRT (if available)
TreeFam:
Gene Tree for NAPRT (if available)

Paralogs for NAPRT Gene

No data available for Paralogs for NAPRT Gene

Variants for NAPRT Gene

Sequence variations from dbSNP and Humsavar for NAPRT Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs744650 -- 143,576,560(-) CTCCC(C/T)AACTT reference, synonymous-codon
rs872935 -- 143,576,541(-) TCGCC(C/G/T)TGGCC reference, missense, synonymous-codon
rs896949 -- 143,578,405(-) CAAAC(C/G)GCACG upstream-variant-2KB, utr-variant-5-prime
rs896950 - 143,578,149(-) CTTGG(C/T)AGCCG reference, missense
rs896951 -- 143,578,148(-) TTGGT(A/C/G)GCCGG synonymous-codon, reference

Variation tolerance for NAPRT Gene

Residual Variation Intolerance Score: 84.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPRT Gene

HapMap Linkage Disequilibrium report
NAPRT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAPRT Gene

Disorders for NAPRT Gene

Relevant External Links for NAPRT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPRT
genes like me logo Genes that share disorders with NAPRT: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPRT Gene

Publications for NAPRT Gene

  1. Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site- directed mutagenesis. (PMID: 21742010) Galassi L. … Magni G. (Biochimie 2012) 2 67
  2. The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. (PMID: 19703994) Watson M. … Beauparlant P. (Mol. Cell. Biol. 2009) 23 67
  3. Elevation of cellular NAD levels by nicotinic acid and involvement of nicotinic acid phosphoribosyltransferase in human cells. (PMID: 17604275) Hara N. … Tsuchiya M. (J. Biol. Chem. 2007) 2 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for NAPRT Gene

Sources for NAPRT Gene

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