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Aliases for NAPG Gene

Aliases for NAPG Gene

  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Gamma 2 3
  • Gamma SNAP 2 3
  • SNAP-Gamma 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Gamma 4
  • Gamma-Soluble NSF Attachment Protein 3
  • Soluble NSF Attachment Protein 3
  • GAMMASNAP 3
  • SNAPG 4

External Ids for NAPG Gene

Previous GeneCards Identifiers for NAPG Gene

  • GC18P010683
  • GC18P010582

Summaries for NAPG Gene

Entrez Gene Summary for NAPG Gene

  • This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

GeneCards Summary for NAPG Gene

NAPG (N-Ethylmaleimide-Sensitive Factor Attachment Protein, Gamma) is a Protein Coding gene.

UniProtKB/Swiss-Prot for NAPG Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Wiki entry for NAPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPG Gene

Genomics for NAPG Gene

Regulatory Elements for NAPG Gene

Genomic Location for NAPG Gene

Start:
10,525,876 bp from pter
End:
10,552,769 bp from pter
Size:
26,894 bases
Orientation:
Plus strand

Genomic View for NAPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPG Gene

Proteins for NAPG Gene

  • Protein details for NAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99747-SNAG_HUMAN
    Recommended name:
    Gamma-soluble NSF attachment protein
    Protein Accession:
    Q99747
    Secondary Accessions:
    • B4DFC9
    • Q9BUV1

    Protein attributes for NAPG Gene

    Size:
    312 amino acids
    Molecular mass:
    34746 Da
    Quaternary structure:
    • Binds RIP11. Interacts with VTI1A (By similarity).

    Alternative splice isoforms for NAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAPG Gene

Proteomics data for NAPG Gene at MOPED

Post-translational modifications for NAPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAPG Gene

No data available for DME Specific Peptides for NAPG Gene

Domains for NAPG Gene

Protein Domains for NAPG Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99747

UniProtKB/Swiss-Prot:

SNAG_HUMAN :
  • Q99747
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPG: view

No data available for Gene Families for NAPG Gene

Function for NAPG Gene

Molecular function for NAPG Gene

UniProtKB/Swiss-Prot Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Ontology (GO) - Molecular Function for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005483 soluble NSF attachment protein activity IBA --
GO:0005515 protein binding IPI 11278501
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with NAPG: view

Phenotypes for NAPG Gene

genes like me logo Genes that share phenotypes with NAPG: view

miRNA for NAPG Gene

miRTarBase miRNAs that target NAPG

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NAPG Gene

Localization for NAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPG Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPG Gene COMPARTMENTS Subcellular localization image for NAPG gene
Compartment Confidence
mitochondrion 5
cytosol 3
golgi apparatus 2
endosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 11278501
GO:0005765 lysosomal membrane IDA 17897319
GO:0031201 SNARE complex IBA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with NAPG: view

Pathways for NAPG Gene

SuperPathways for NAPG Gene

No Data Available

Gene Ontology (GO) - Biological Process for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 11278501
GO:0006886 intracellular protein transport IBA --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8455721
GO:0050821 protein stabilization NAS 11278501
GO:0061025 membrane fusion IBA --
genes like me logo Genes that share ontologies with NAPG: view

No data available for Pathways by source for NAPG Gene

Compounds for NAPG Gene

(3) Novoseek inferred chemical compound relationships for NAPG Gene

Compound -log(P) Hits PubMed IDs
n-ethylmaleimide 64.4 3
atp 48.7 6
calcium 0.663 1
genes like me logo Genes that share compounds with NAPG: view

Transcripts for NAPG Gene

Unigene Clusters for NAPG Gene

N-ethylmaleimide-sensitive factor attachment protein, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for NAPG Gene

GeneLoc Exon Structure for
NAPG
ECgene alternative splicing isoforms for
NAPG

Expression for NAPG Gene

mRNA expression in normal human tissues for NAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAPG Gene

SOURCE GeneReport for Unigene cluster for NAPG Gene Hs.464622

genes like me logo Genes that share expressions with NAPG: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPG Gene

Orthologs for NAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for NAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPG 35
  • 99.79 (n)
  • 100 (a)
NAPG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAPG 35
  • 86 (n)
  • 95.19 (a)
NAPG 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPG 35
  • 91.85 (n)
  • 96.78 (a)
NAPG 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napg 35
  • 88.25 (n)
  • 98.08 (a)
Napg 16
Napg 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAPG 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPG 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAPG 35
  • 80.24 (n)
  • 89.74 (a)
NAPG 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAPG 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia napg 35
  • 77.09 (n)
  • 86.97 (a)
zebrafish
(Danio rerio)
Actinopterygii napg 35
  • 70.98 (n)
  • 74.11 (a)
napg 36
  • 74 (a)
OneToMany
napgl 36
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005632 35
  • 49.55 (n)
  • 41.84 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6208 36
  • 30 (a)
OneToMany
gammaSnap 35
  • 49.72 (n)
  • 39.8 (a)
gammaSnap 36
  • 39 (a)
OneToMany
gammaSnap 37
  • 38 (a)
CG6208 37
  • 32 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y59A8B.8 35
  • 48.96 (n)
  • 36.46 (a)
Y59A8B.25 36
  • 29 (a)
OneToMany
Y59A8B.8 36
  • 34 (a)
OneToMany
Y59A8B.8 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for NAPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPG Gene

ENSEMBL:
Gene Tree for NAPG (if available)
TreeFam:
Gene Tree for NAPG (if available)

Paralogs for NAPG Gene

Pseudogenes.org Pseudogenes for NAPG Gene

genes like me logo Genes that share paralogs with NAPG: view

No data available for Paralogs for NAPG Gene

Variants for NAPG Gene

Sequence variations from dbSNP and Humsavar for NAPG Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs9317 -- 10,552,475(+) TGTCT(C/T)CCAGA utr-variant-3-prime
rs10207 -- 10,551,785(-) CACCC(A/G)AGACC utr-variant-3-prime
rs14587 -- 10,552,666(-) AGAGT(A/T)GGGAA utr-variant-3-prime
rs15937 -- 10,551,605(-) TACTT(C/T)GGCAG utr-variant-3-prime
rs483995 -- 10,533,305(-) TCTAT(A/T)ACGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAPG Gene

Variant ID Type Subtype PubMed ID
esv2667923 CNV Deletion 23128226

Relevant External Links for NAPG Gene

HapMap Linkage Disequilibrium report
NAPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPG Gene

Disorders for NAPG Gene

Relevant External Links for NAPG

Genetic Association Database (GAD)
NAPG
Human Genome Epidemiology (HuGE) Navigator
NAPG
genes like me logo Genes that share disorders with NAPG: view

No data available for UniProtKB/Swiss-Prot for NAPG Gene

Publications for NAPG Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons P.P. … Whiteheart S.W. (Blood 1997) 2 3 4 23
  2. Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. (PMID: 16395123) Weller A.E. … Berrettini W.H. (Psychiatr. Genet. 2006) 3 23 48
  3. Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. (PMID: 11278501) Chen D. … Whiteheart S.W. (J. Biol. Chem. 2001) 3 4 23
  4. Mapping of functional domains of gamma-SNAP. (PMID: 12554740) Tani K. … Tagaya M. (J. Biol. Chem. 2003) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NAPG Gene

Sources for NAPG Gene

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