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Aliases for NAPG Gene

Aliases for NAPG Gene

  • NSF Attachment Protein Gamma 2 3
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Gamma 2 3 5
  • Gamma SNAP 2 3
  • SNAP-Gamma 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Gamma 4
  • Soluble NSF Attachment Protein 3
  • SNAPG 4

External Ids for NAPG Gene

Previous GeneCards Identifiers for NAPG Gene

  • GC18P010683
  • GC18P010582

Summaries for NAPG Gene

Entrez Gene Summary for NAPG Gene

  • This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

GeneCards Summary for NAPG Gene

NAPG (NSF Attachment Protein Gamma) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Transport to the Golgi and subsequent modification. GO annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity.

UniProtKB/Swiss-Prot for NAPG Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPG Gene

Genomics for NAPG Gene

Regulatory Elements for NAPG Gene

Enhancers for NAPG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAPG on UCSC Golden Path with GeneCards custom track

Promoters for NAPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAPG on UCSC Golden Path with GeneCards custom track

Genomic Location for NAPG Gene

10,525,876 bp from pter
10,552,769 bp from pter
26,894 bases
Plus strand

Genomic View for NAPG Gene

Genes around NAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPG Gene

Proteins for NAPG Gene

  • Protein details for NAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-soluble NSF attachment protein
    Protein Accession:
    Secondary Accessions:
    • B4DFC9
    • Q9BUV1

    Protein attributes for NAPG Gene

    312 amino acids
    Molecular mass:
    34746 Da
    Quaternary structure:
    • Binds RIP11. Interacts with VTI1A (By similarity).

    Alternative splice isoforms for NAPG Gene


neXtProt entry for NAPG Gene

Proteomics data for NAPG Gene at MOPED

Post-translational modifications for NAPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAPG Gene

No data available for DME Specific Peptides for NAPG Gene

Domains & Families for NAPG Gene

Protein Domains for NAPG Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SNAP family.
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPG: view

No data available for Gene Families for NAPG Gene

Function for NAPG Gene

Molecular function for NAPG Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
genes like me logo Genes that share phenotypes with NAPG: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPG Gene

Localization for NAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPG Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for NAPG Gene COMPARTMENTS Subcellular localization image for NAPG gene
Compartment Confidence
extracellular 5
lysosome 5
mitochondrion 5
vacuole 5
cytosol 4
plasma membrane 2
endosome 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with NAPG: view

Pathways & Interactions for NAPG Gene

genes like me logo Genes that share pathways with NAPG: view

Gene Ontology (GO) - Biological Process for NAPG Gene


No data available for SIGNOR curated interactions for NAPG Gene

Drugs & Compounds for NAPG Gene

(3) Drugs for NAPG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NAPG: view

Transcripts for NAPG Gene

Unigene Clusters for NAPG Gene

N-ethylmaleimide-sensitive factor attachment protein, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP3: -

Relevant External Links for NAPG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NAPG Gene

mRNA expression in normal human tissues for NAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPG Gene

This gene is overexpressed in Bone (19.2) and Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAPG Gene

SOURCE GeneReport for Unigene cluster for NAPG Gene Hs.464622

genes like me logo Genes that share expression patterns with NAPG: view

Protein tissue co-expression partners for NAPG Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPG Gene

Orthologs for NAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for NAPG Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NAPG 35
  • 86 (n)
  • 95.19 (a)
  • 95 (a)
(Canis familiaris)
Mammalia NAPG 35
  • 91.85 (n)
  • 96.78 (a)
  • 96 (a)
(Mus musculus)
Mammalia Napg 35
  • 88.25 (n)
  • 98.08 (a)
Napg 16
Napg 36
  • 98 (a)
(Pan troglodytes)
Mammalia NAPG 35
  • 99.79 (n)
  • 100 (a)
  • 100 (a)
(Monodelphis domestica)
Mammalia NAPG 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia NAPG 36
  • 89 (a)
(Gallus gallus)
Aves NAPG 35
  • 80.24 (n)
  • 89.74 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia NAPG 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia napg 35
  • 77.09 (n)
  • 86.97 (a)
(Danio rerio)
Actinopterygii napg 35
  • 70.98 (n)
  • 74.11 (a)
napg 36
  • 74 (a)
napgl 36
  • 75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6208 37
  • 32 (a)
gammaSnap 37
  • 38 (a)
gammaSnap 35
  • 49.72 (n)
  • 39.8 (a)
CG6208 36
  • 30 (a)
gammaSnap 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005632 35
  • 49.55 (n)
  • 41.84 (a)
(Caenorhabditis elegans)
Secernentea Y59A8B.8 37
  • 32 (a)
CELE_Y59A8B.8 35
  • 48.96 (n)
  • 36.46 (a)
Y59A8B.25 36
  • 29 (a)
Y59A8B.8 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for NAPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPG Gene

Gene Tree for NAPG (if available)
Gene Tree for NAPG (if available)

Paralogs for NAPG Gene Pseudogenes for NAPG Gene

genes like me logo Genes that share paralogs with NAPG: view

No data available for Paralogs for NAPG Gene

Variants for NAPG Gene

Sequence variations from dbSNP and Humsavar for NAPG Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2305370 - 10,550,124(-) TTCTT(C/G)TTGAT reference, missense
VAR_052027 -
rs9317 -- 10,552,475(+) TGTCT(C/T)CCAGA utr-variant-3-prime
rs10207 -- 10,551,785(-) CACCC(A/G)AGACC utr-variant-3-prime
rs14587 -- 10,552,666(-) AGAGT(A/T)GGGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAPG Gene

Variant ID Type Subtype PubMed ID
esv2667923 CNV Deletion 23128226

Variation tolerance for NAPG Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.90% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NAPG Gene

Disorders for NAPG Gene

Relevant External Links for NAPG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPG Gene

Publications for NAPG Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons P.P. … Whiteheart S.W. (Blood 1997) 2 3 4 23 67
  2. Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. (PMID: 16395123) Weller A.E. … Berrettini W.H. (Psychiatr. Genet. 2006) 3 23
  3. Mapping of functional domains of gamma-SNAP. (PMID: 12554740) Tani K. … Tagaya M. (J. Biol. Chem. 2003) 3 23
  4. Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. (PMID: 11278501) Chen D. … Whiteheart S.W. (J. Biol. Chem. 2001) 3 23
  5. SNAP family of NSF attachment proteins includes a brain-specific isoform. (PMID: 8455721) Whiteheart S.W. … Rothman J.E. (Nature 1993) 3 23

Products for NAPG Gene

Sources for NAPG Gene