NAPG Gene
protein-coding GIFtS: 51
GCID: GC18P010516
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|
N-ethylmaleimide-sensitive factor attachment protein, gamma
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Aliases
for NAPG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Ethylmaleimide-Sensitive Factor Attachment Protein, Gamma1 2 | | Gamma-Soluble NSF Attachment Protein2 | | SNAP-Gamma1 | | Soluble NSF Attachment Protein2 | | GAMMASNAP2 | | SNAPG3 | | Gamma SNAP2 | | N-Ethylmaleimide-Sensitive Factor Attachment Protein Gamma3 |
Export aliases for NAPG gene to outside databasesPrevious GC identifers: GC18P010683 GC18P010582 |
Summaries
for NAPG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NAPG:
This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enableN-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be generalcomponents of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must becontrolled by SNAP receptors particular to the membranes being fused. The product of this gene mediates plateletexocytosis and controls the membrane fusion events of this process.(provided by RefSeq, Dec 2008)
UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus
Gene Wiki entry for NAPG
|
Genomic Views
for NAPG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NAPG gene promoter:
HOXA9 C/EBPbeta Pax-5 E2F E2F-1 FOXO1a POU3F2 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NAPG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.21NAPG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P010516: view genomic region
(about GC identifiers)
Start:
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10,525,873 bp from pter |
End:
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10,552,766 bp from pter |
Size:
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26,894 bases |
Orientation:
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plus strand |
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Proteins
for NAPG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747 (See
protein sequence)Recommended Name: Gamma-soluble NSF attachment protein Size: 312 amino acids; 34746 Da
Subunit: Binds RIP11. Interacts with VTI1A (By similarity)
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: Q9BUV1Explore the universe of human proteins at neXtProt for NAPG: NX_Q99747
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99747
NAPG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003817.1
ENSEMBL proteins: ENSP00000464496 ENSP00000463265 ENSP00000324628 ENSP00000463018 ENSP00000442849
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NAPG for ontologies About GeneDecksing
NAPG Antibody Products:
Assay Products for NAPG: |
Protein
Domains /
Families
for NAPG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NAPG for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99747ProtoNet protein and cluster: Q99747 UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747Similarity: Belongs to the SNAP family |
Function
for NAPG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAPG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAPG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NAPG | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPG |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPG |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
NAPG for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NAPG:
|
Pathways & Interactions
for NAPG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAPG
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for NAPG (Q997473 ENSP000003246284) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
NAPG for ontologies About GeneDecksing
|
Drugs & Compounds
for NAPG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NAPG for compounds About GeneDecksing
 Browse Tocris compounds for NAPG
3 Novoseek chemical compound relationships for NAPG gene About this table
Search CenterWatch for drugs/clinical trials and news about NAPG / SNAG
|
Transcripts
for NAPG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NAPG gene: NM_003826.2 Unigene Cluster for NAPG: N-ethylmaleimide-sensitive factor attachment protein, gamma Hs.464622 [show with all ESTs]Unigene Representative Sequence: NM_0038268 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000580483 ENST00000580224 ENST00000322897(uc002kon.3 uc010wzr.2)
ENST00000582978 ENST00000580746 ENST00000582472 ENST00000583367(uc002kop.3)
ENST00000542979
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAPG (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAPG
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NAPG (NM_003826) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NAPG | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPG |
Additional cDNA sequence: AF131752.1 AK023725.1 AK294038.1 AK314495.1 BC001889.1 CR536554.1 U78107.1 9 DOTS entries: DT.97843470 DT.412344 DT.100775687 DT.100001089 DT.100661614 DT.100812344 DT.40213778 DT.91647160 DT.92422036 24/231 AceView cDNA sequences (see all 231): AL708551 AA261908 BM512461 BM977835 CA312045 N90028 AI597642 AA760853 AA767196 BI760705 AA485349 BI084064 BU684546 BM998189 BQ221138 CA430838 F09199 BF448939 CA446333 AA908316 BQ188284 BM807739 AI968169 AA284132
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NAPG About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
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| SP1: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NAPG
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Expression
for NAPG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NAPG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATGCTCA
About this image
See NAPG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NAPG
SOURCE GeneReport for Unigene cluster: Hs.464622
SABiosciences Custom PCR Arrays for NAPG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAPG
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAPG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAPG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPG | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPG |
Orthologs
for NAPG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NAPG gene from 8/25 species (see all 25) About this table
ENSEMBL Gene Tree for NAPG (if available)
TreeFam Gene Tree for NAPG (if available) |
Paralogs
for NAPG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NAPG gene
NAPG for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for NAPG
PGOHUM00000238878 PGOHUM00000260122
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Genomic Variants
for NAPG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NAPG (10525873 - 10552766 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NAPG: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAPG |
|
Disorders
/ Diseases
for NAPG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NAPG for disorders About GeneDecksing
OMIM gene information: 603216
OMIM disorders: --
5  diseases for NAPG: About MalaCardshirschsprung's disease bipolar disorder down syndrome tetanus
alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: NAPG (3 documents)
Export disorders for NAPG gene to outside databases
|
Publications
for NAPG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NAPG gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with NAPG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PubMed id 9269766)1, 2, 3, 9 Lemons P.P.... Whiteheart S.W. (1997)
- Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. (PubMed id 11278501)1, 2, 9 Chen D.... Whiteheart S.W. (2001)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mapping of functional domains of gamma-SNAP. (PubMed id 12554740)1, 9 Tani K....Tagaya M. (2003)
- Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. (PubMed id 16395123)1, 9 Weller A.E....Berrettini W.H. (2006)
- SNAP family of NSF attachment proteins includes a brain-specific isoform. (PubMed id 8455721)1, 9 Whiteheart S.W....Rothman J.E. (1993)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The 18p11.22 locus is associated with never smoker non -small cell lung cancer susceptibility in Korean populations. (PubMed id 21866343)1 Ahn M.J....Park K. (2012)
- NAPG may not be a common risk gene shared by bipolar d isorder and schizophrenia in Chinese population. (PubMed id 22113424)1 Li X.W....He G. (2012)
|
External Searches for NAPG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NAPG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NAPG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAPG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NAPG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NAPG gene:
Search GeneIP for patents involving NAPG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NAPG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NAPG | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAPG | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NAPG | | | OriGene Protein Over-expression Lysate for NAPG | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NAPG | | OriGene 3'-UTR Clone for NAPG | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NAPG | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NAPG | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NAPG | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NAPG | | OriGene Custom Protein Services for NAPG | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NAPG | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAPG | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPG | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPG | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPG | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAPG |
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| |  |  |  |  | | | | | | Recombinant Protein for NAPG |
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|  |  |  | | | | ThermoFisher Antibodies for NAPG |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPG |
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