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Aliases for NAPG Gene

Aliases for NAPG Gene

  • NSF Attachment Protein Gamma 2 3 5
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Gamma 2 3
  • SNAP-Gamma 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Gamma 4
  • Gamma-Soluble NSF Attachment Protein 3
  • Soluble NSF Attachment Protein 3
  • Gamma SNAP 2
  • GAMMASNAP 3
  • SNAPG 4

External Ids for NAPG Gene

Previous GeneCards Identifiers for NAPG Gene

  • GC18P010683
  • GC18P010582

Summaries for NAPG Gene

Entrez Gene Summary for NAPG Gene

  • This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process.[provided by RefSeq, Dec 2008]

GeneCards Summary for NAPG Gene

NAPG (NSF Attachment Protein Gamma) is a Protein Coding gene. Among its related pathways are Golgi-to-ER retrograde transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity.

UniProtKB/Swiss-Prot for NAPG Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPG Gene

Additional gene information for NAPG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPG Gene

Genomics for NAPG Gene

Regulatory Elements for NAPG Gene

Enhancers for NAPG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H010524 1.1 ENCODE 51.5 +0.2 240 3.3 FOXA2 ATF1 ARID4B SIN3A YBX1 DMAP1 YY1 ETS1 GLIS2 ELK1 NAPG PIR40228
GH18H010529 0.9 ENCODE 51.4 +4.0 4022 1.5 HDAC1 HDGF PKNOX1 ATF1 ZBTB40 BATF ATF7 SMARCA5 ZBTB11 ELF1 NAPG PIR40228
GH18H010518 1.1 Ensembl ENCODE 41.5 -6.6 -6550 2.4 RB1 MLX ZNF76 BMI1 DNMT3B ZNF2 RAD21 RARA ZNF143 FOS NAPG GC18M010465
GH18H010481 1.3 Ensembl ENCODE dbSUPER 22 -43.0 -43046 2.5 CTCF BACH1 BMI1 EBF1 BATF POLR2A ATF7 RUNX3 CREM CHD2 NAPG APCDD1 GC18M010465
GH18H010490 0.8 ENCODE 34.8 -34.9 -34885 0.9 SOX13 CTCF PKNOX1 SAP130 RAD21 TEAD3 SMC3 ZNF143 RUNX3 IKZF2 NAPG APCDD1 GC18M010465
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NAPG on UCSC Golden Path with GeneCards custom track

Promoters for NAPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000100768 624 1801 FOXA2 ATF1 SIN3A ARID4B DMAP1 YY1 ETS1 ELK1 ZNF143 ZNF207

Genomic Locations for NAPG Gene

Genomic Locations for NAPG Gene
chr18:10,525,876-10,552,769
(GRCh38/hg38)
Size:
26,894 bases
Orientation:
Plus strand
chr18:10,525,873-10,552,766
(GRCh37/hg19)

Genomic View for NAPG Gene

Genes around NAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPG Gene

Proteins for NAPG Gene

  • Protein details for NAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99747-SNAG_HUMAN
    Recommended name:
    Gamma-soluble NSF attachment protein
    Protein Accession:
    Q99747
    Secondary Accessions:
    • B4DFC9
    • Q9BUV1

    Protein attributes for NAPG Gene

    Size:
    312 amino acids
    Molecular mass:
    34746 Da
    Quaternary structure:
    • Binds RIP11. Interacts with VTI1A (By similarity).

    Alternative splice isoforms for NAPG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAPG Gene

Post-translational modifications for NAPG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAPG Gene

No data available for DME Specific Peptides for NAPG Gene

Domains & Families for NAPG Gene

Gene Families for NAPG Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NAPG Gene

Graphical View of Domain Structure for InterPro Entry

Q99747

UniProtKB/Swiss-Prot:

SNAG_HUMAN :
  • Belongs to the SNAP family.
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPG: view

Function for NAPG Gene

Molecular function for NAPG Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Phenotypes From GWAS Catalog for NAPG Gene

Gene Ontology (GO) - Molecular Function for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005483 soluble NSF attachment protein activity IBA --
GO:0005515 protein binding IPI 11278501
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with NAPG: view
genes like me logo Genes that share phenotypes with NAPG: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NAPG Gene

Localization for NAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPG Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NAPG gene
Compartment Confidence
extracellular 5
mitochondrion 5
lysosome 5
cytosol 4
plasma membrane 2
golgi apparatus 2
nucleus 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IDA 11278501
GO:0005765 lysosomal membrane IDA 17897319
GO:0016020 membrane IEA --
GO:0031201 SNARE complex IBA --
genes like me logo Genes that share ontologies with NAPG: view

Pathways & Interactions for NAPG Gene

genes like me logo Genes that share pathways with NAPG: view

Gene Ontology (GO) - Biological Process for NAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly NAS 11278501
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IBA,IEA --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8455721
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NAPG: view

No data available for SIGNOR curated interactions for NAPG Gene

Drugs & Compounds for NAPG Gene

(3) Drugs for NAPG Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NAPG: view

Transcripts for NAPG Gene

Unigene Clusters for NAPG Gene

N-ethylmaleimide-sensitive factor attachment protein, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for NAPG Gene

GeneLoc Exon Structure for
NAPG
ECgene alternative splicing isoforms for
NAPG

Expression for NAPG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPG Gene

This gene is overexpressed in Bone (19.2) and Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAPG Gene



Protein tissue co-expression partners for NAPG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NAPG Gene:

NAPG

SOURCE GeneReport for Unigene cluster for NAPG Gene:

Hs.464622

Evidence on tissue expression from TISSUES for NAPG Gene

  • Nervous system(4.9)
  • Liver(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with NAPG: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NAPG Gene

Orthologs for NAPG Gene

This gene was present in the common ancestor of animals.

Orthologs for NAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPG 33 34
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia NAPG 33 34
  • 91.85 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NAPG 34
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napg 33 16 34
  • 88.25 (n)
oppossum
(Monodelphis domestica)
Mammalia NAPG 34
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAPG 34 33
  • 86 (n)
OneToOne
chicken
(Gallus gallus)
Aves NAPG 33 34
  • 80.24 (n)
lizard
(Anolis carolinensis)
Reptilia NAPG 34
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia napg 33
  • 77.09 (n)
zebrafish
(Danio rerio)
Actinopterygii napgl 34
  • 75 (a)
OneToMany
napg 33 34
  • 70.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta gammaSnap 35 33 34
  • 49.72 (n)
CG6208 35 34
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005632 33
  • 49.55 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y59A8B.8 33
  • 48.96 (n)
Y59A8B.8 35 34
  • 32 (a)
Y59A8B.25 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 44 (a)
OneToOne
Species where no ortholog for NAPG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPG Gene

ENSEMBL:
Gene Tree for NAPG (if available)
TreeFam:
Gene Tree for NAPG (if available)

Paralogs for NAPG Gene

genes like me logo Genes that share paralogs with NAPG: view

No data available for Paralogs for NAPG Gene

Variants for NAPG Gene

Sequence variations from dbSNP and Humsavar for NAPG Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000087769 -- 10,535,765(+) CAAAG(-/TAA)TAATA intron-variant
rs1000139316 -- 10,542,075(+) CCATT(-/G)TTTTA intron-variant
rs1000408137 -- 10,524,300(+) TAATA(A/T)ATCTA upstream-variant-2KB
rs1000544444 -- 10,535,501(+) CATGC(C/T)TGTAA intron-variant
rs1000549051 -- 10,551,005(+) TTTTG(G/T)TTTTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAPG Gene

Variant ID Type Subtype PubMed ID
nsv1059110 CNV gain 25217958
esv2667923 CNV deletion 23128226

Variation tolerance for NAPG Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPG Gene

Disorders for NAPG Gene

Relevant External Links for NAPG

Genetic Association Database (GAD)
NAPG
Human Genome Epidemiology (HuGE) Navigator
NAPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPG

No disorders were found for NAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPG Gene

Publications for NAPG Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons PP … Whiteheart SW (Blood 1997) 2 3 4 22 60
  2. Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. (PMID: 16395123) Weller AE … Berrettini WH (Psychiatric genetics 2006) 3 22 45 60
  3. Gaf-1, a gamma -SNAP-binding protein associated with the mitochondria. (PMID: 11278501) Chen D … Whiteheart SW (The Journal of biological chemistry 2001) 3 4 22 60
  4. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PMID: 19328558) Yosifova A … Nakamura Y (Journal of affective disorders 2009) 3 45 60
  5. Association study on the NAPG gene and bipolar disorder in the Chinese Han population. (PMID: 19429185) Li X … He G (Neuroscience letters 2009) 3 45 60

Products for NAPG Gene

Sources for NAPG Gene

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