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Aliases & Descriptions for NAPG
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| GAMMASNAP 2 | | SNAP-gamma 3 | | SNAPG 3 |
| | | Descriptions |
|---|
| N-ethylmaleimide-sensitive factor attachment protein gamma 3 | | N-ethylmaleimide-sensitive factor attachment protein, gamma 2 | | gamma SNAP 2 | | soluble NSF attachment protein 2 |
|
| | Search outside databases for aliases for NAPG genePrevious GC identifers: GC18P010683 GC18P010582 |
Summaries for NAPG(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for NAPG: This gene encodes soluble NSF attachment protein gamma. The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused. The product of this gene mediates platelet exocytosis and controls the membrane fusion events of this process. UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatusGene Wiki entry for NAPG |
Genomic Location for NAPG
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the NAPG gene 
Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.21NAPG Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P010516:
(about GC identifiers)
Start:
|
10,516,031 bp from pter |
End:
|
10,540,372 bp from pter |
Size:
|
24,342 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000018.8 NT_010859.14
| Proteins for NAPG
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747 (See
protein sequence)Recommended Name: Gamma-soluble NSF attachment protein Size: 312 amino acids; 34746 Da
Subunit: Binds RIP11
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: Q9BUV1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003817.1
ENSEMBL proteins: ENSP00000324628
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NAPG 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for NAPG: Assays for NAPG: | Protein
Domains/ Families for NAPG(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99747
ProtoNet protein and cluster: Q99747 UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747Similarity: Belongs to the SNAP family | Gene Function for NAPG
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003826
Applied Biosystems Silencer® siRNAs for NAPG
Sigma-Aldrich siRNA for NAPG  Sigma-Aldrich shRNA for NAPG  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003826                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003826                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003826 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003826
UniProtKB/Swiss-Prot: SNAG_HUMAN, Q99747Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for NAPG
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for NAPG (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for NAPG 
--5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for NAPG(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for NAPG 2 Novoseek chemical compound relationships for NAPG gene
About this table
|
Transcripts for NAPG(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003826
Sigma-Aldrich siRNA for NAPG  Sigma-Aldrich shRNA for NAPG  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003826 REFSEQ mRNAs for NAPG gene: NM_003826.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003826               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003826                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003826                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003826  Additional cDNA sequence: AF131752.1 AK023725.1 AK294038.1 AK314495.1 BC001889.1 CR536554.1 CR602036.1 U78107.1 9 DOTS entries: DT.97843470 DT.412344 DT.100775687 DT.100001089 DT.100661614 DT.100812344 DT.40213778 DT.91647160 DT.92422036 24/231 AceView cDNA sequences (see all 231
):CR536554 AA767196 BC001889 AA485349 AA760853 BF060754 N90028 CA447657 BI760705 BQ045235 AW152374 AL559231 AK126942 R06227 AA921903 BI084064 AA972946 CB960558 BU173657 AW451167 BX486893 AI597642 AA903085 CA312045
highest scoring ESTs for NAPG:U78107 AA010503 AA127677 AA258463 AI159800 AI467980 AI628298 AI683876 AI942385 AL580888 Unigene Cluster for NAPG: N-ethylmaleimide-sensitive factor attachment protein, gamma Hs.464622 [show with all ESTs]Unigene Representative Sequence: NM_003826
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NAPG
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for NAPG
1 Ensembl transcript including schematic representation: ENST00000322897
|
Expression for NAPG
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| NAPG expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for NAPG
1 / 2 / 3 6 probe-sets matching NAPG gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATATGCTCA
SOURCE GeneReport for Unigene cluster: Hs.464622
Expression variation in blood from EXPOLDB for NAPG |
Orthologs for NAPG
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NAPG gene from 5/13 species (see all 13
)
About this table Species with no ortholog for NAPG
ENSEMBL Gene Tree for NAPG | Paralogs for NAPG(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for NAPG(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for NAPG (up to first 250kb)
|
Disorders & Mutations for NAPG
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603216
Human Genome Epidemiology Navigator: NAPG (3 documents)
|
Medical News for NAPG(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for NAPG (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/70 PubMed articles for NAPG gene (see all 70
):- Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PubMed id 9269766)1, 2, 3, 4 Lemons P.P.... Whiteheart S.W. (1997)
- Gaf-1, a gamma-SNAP-binding protein associated with the mitochondria. (PubMed id 11278501)1, 3, 4 Chen D.... Whiteheart S.W. (2001)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Mapping of functional domains of gamma-SNAP. (PubMed id 12554740)1, 3 Tani K....Tagaya M. (2003)
- Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder. (PubMed id 16395123)1, 3 Weller A.E....Berrettini W.H. (2006)
- SNAP family of NSF attachment proteins includes a brain-specific isoform. (PubMed id 8455721)1, 3 Whiteheart S.W....Rothman J.E. (1993)
- Association study on the NAPG gene and bipolar disorder in the Chinese Han population. (PubMed id 19429185)3 Li X....He G. (2009)
- Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. (PubMed id 19328558)3 Yosifova A....Nakamura Y. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
|
Search for NAPG
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NAPG
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing NAPG
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NAPG(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for NAPG(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for NAPG:

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