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NAPEPLD Gene

protein-coding   GIFtS: 59
GCID: GC07M102742

N-Acyl Phosphatidylethanolamine Phospholipase D

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Acyl Phosphatidylethanolamine Phospholipase D1 2 3     FMP302
N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D1 2     C7orf183
NAPE-PLD2 3     EC 3.1.4.543
NAPE-Hydrolyzing Phospholipase D2 3     EC 3.1.48
Chromosome 7 Open Reading Frame 181     

External Ids:    HGNC: 216831   Entrez Gene: 2222362   Ensembl: ENSG000001610487   OMIM: 6123345   UniProtKB: Q6IQ203   

Export aliases for NAPEPLD gene to outside databases

Previous GC identifers: GC07M102528 GC07M097103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAPEPLD Gene:
NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from
N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et
al., 2004 (PubMed 14634025)).(supplied by OMIM, Oct 2008)

GeneCards Summary for NAPEPLD Gene:
NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D) is a protein-coding gene. GO annotations related to this gene include NAPE-specific phospholipase D activity.

UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20
Function: Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and
phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of
cannabinoid and vanilloid receptors (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007933.16  NT_187559.1  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAPEPLD gene promoter:
         TBP   COUP-TF1   SRF   SRF (504 AA)   COUP   HNF-4alpha2   AP-4   POU6F1 (c2)   HNF-4alpha1   COUP-TF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NAPEPLD promoter sequence
   Search Chromatin IP Primers for NAPEPLD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAPEPLD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22.1

NAPEPLD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPEPLD gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M102742:  view genomic region     (about GC identifiers)

Start:
102,740,023 bp from pter      End:
102,790,007 bp from pter
Size:
49,985 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 102,100,389-102,149,935     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20 (See protein sequence)
Recommended Name: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D  
Size: 393 amino acids; 45596 Da
Cofactor: Binds 1 or 2 zinc ions per subunit (By similarity)
Subunit: Monomer (By similarity)
Secondary accessions: Q5CZ87 Q769K1

Explore the universe of human proteins at neXtProt for NAPEPLD: NX_Q6IQ20

Explore proteomics data for NAPEPLD at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys73, Lys296
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NAPEPLD (Q6IQ20) (see all 7)
     ALNERFG  MVEMDELI  MGPKRFRR  SHNHYDHLD 


    See NAPEPLD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116310.1  NP_945341.3  

    ENSEMBL proteins: 
     ENSP00000340093   ENSP00000407112   ENSP00000412376   ENSP00000419188   ENSP00000395138  
     ENSP00000392775   ENSP00000404391   ENSP00000414778   ENSP00000414364  
    Reactome Protein details: Q6IQ20

    NAPEPLD Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NAPEPLD

     
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    Search eBioscience for ELISAs for NAPEPLD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: N-Acylphosphatidylethanolamine-phospholipase D
    Endocannabinoid turnover

    2 InterPro protein domains:
     IPR001279 Beta-lactamas-like
     IPR024884 NAPE-PLD

    Graphical View of Domain Structure for InterPro Entry Q6IQ20

    ProtoNet protein and cluster: Q6IQ20

    UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20
    Similarity: Belongs to the NAPE-PLD family


    Find genes that share domains with NAPEPLD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NAPEP_HUMAN, Q6IQ20
    Function: Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and
    phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of
    cannabinoid and vanilloid receptors (By similarity)
    Catalytic activity: An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol
    3-phosphate
    Enzyme regulation: Activity is stimulated by divalent cations (By similarity)

         Enzyme Numbers (IUBMB): EC 3.1.42 EC 3.1.4.541

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004620phospholipase activity ----
    GO:0008270zinc ion binding IEA--
    GO:0070290NAPE-specific phospholipase D activity IEA--
         
    Find genes that share ontologies with NAPEPLD           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Napepld):
     homeostasis/metabolism  nervous system  no phenotypic analysis 

    Find genes that share phenotypes with NAPEPLD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NAPEPLD: Napepldtm1.1Rpa Napepldtm1Crv Napepldtm1.2Itl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAPEPLD
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    miRNA
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    miRTarBase miRNAs that target NAPEPLD:
    hsa-mir-17-5p (MIRT050896), hsa-mir-1229-3p (MIRT036340)

    Block miRNA regulation of human, mouse, rat NAPEPLD using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAPEPLD (see all 77):
    hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-371-5p hsa-miR-877* hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidNAPEPLD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAPEPLD
    Predesigned siRNA for gene silencing in human, mouse, rat NAPEPLD

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NAPEP_HUMAN, Q6IQ20: Membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042622photoreceptor outer segment membrane TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with NAPEPLD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAPEPLD About    
    See pathways by source

    SuperPathContained pathways About
    1Diseases associated with visual transduction
    Diseases associated with visual transduction0.43
    Retinoid cycle disease events0.00
    Biosynthesis of A2E, implicated in retinal degradation0.00
    2Circadian entrainment
    Retrograde endocannabinoid signaling0.51
    3phospholipases
    Anandamide biosynthesis and metabolism0.34
    4Disease
    Disease


    Find genes that share SuperPaths with NAPEPLD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for NAPEPLD
        Anandamide biosynthesis and metabolism

    1 Reactome Pathway for NAPEPLD
        Biosynthesis of A2E, implicated in retinal degradation


    1 Kegg Pathway  (Kegg details for NAPEPLD):
        Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAPEPLD
    Interactions:

        Search GeneGlobe Interaction Network for NAPEPLD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAPEPLD (Q6IQ203 ENSP000003400934) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRLS1Q9UJA23, ENSP000003681404I2D: score=1 STRING: ENSP00000368140
    MTIF2P461993, ENSP000002636294I2D: score=1 STRING: ENSP00000263629
    RHOT1Q8IXI23, ENSP000003511324I2D: score=1 STRING: ENSP00000351132
    PISDQ9UG563, ENSP000002660954I2D: score=1 STRING: ENSP00000266095
    PHB2Q996233, ENSP000003823624I2D: score=1 STRING: ENSP00000382362
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009395phospholipid catabolic process IEA--

    Find genes that share ontologies with NAPEPLD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAPEPLD (NAPEP)

    Selected HMDB Compounds for NAPEPLD (see all 1088)    About this table
    CompoundSynonyms CAS #PubMed Ids
    PE(O-16:1(1Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 15)--12486725
    PE(O-18:1(1Z)/20:4(5Z,8Z,11Z,14Z))1-alkenyl-2-acyl-glycerophosphoethanolamine (see all 19)103597-60-012486725
    PE(P-16:0e/0:0)2-azaniumylethyl [(2R)-3-[(E)-hexadec-1-enoxy]-2-hydroxy-propyl] phosphate;1-(1Z-hexadecenyl)-sn-glycero-3-phosphoethanolamine ;LysoPE(dm16:0e) --12486725
    PE(P-16:0e/18:1(9Z))2-(9Z-octadecanoyl)-1-hexadecyl-sn-glycero-3-phosphoethanolamine --12486725
    AnandamideAnandamide (20.4, n-6) (see all 13)94421-68-8--
    PA(16:0/16:0)Dipalmitoylphosphatidic acid (see all 25)7091-44-3--
    PA(16:0/18:1(11Z))PA(16:0/18:1n7) (see all 10)----
    PA(16:0/18:1(9Z))PA(16:0/18:1n9) (see all 10)----
    PA(16:0/18:2(9Z,12Z))PA(34:2) (see all 10)----
    PA(16:0e/18:0)2-octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate ;PA(o-16:0/18:0) ----



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NAPEPLD gene (2 alternative transcripts): 
    NM_001122838.1  NM_198990.4  

    Unigene Cluster for NAPEPLD:

    N-acyl phosphatidylethanolamine phospholipase D
    Hs.324271  [show with all ESTs]
    Unigene Representative Sequence: NM_001122838
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414118 ENST00000341533(uc003vbc.2 uc003vbe.2) ENST00000417955(uc003vbd.2 uc011klj.1)
    ENST00000422589 ENST00000465647 ENST00000420631 ENST00000427257 ENST00000418294
    ENST00000479761(uc003vbf.3) ENST00000425379 ENST00000455523
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NAPEPLD (see all 77):
    hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-15a hsa-miR-106a hsa-miR-371-5p hsa-miR-877* hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidNAPEPLD 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAPEPLD
      QuantiTect SYBR Green Assays in human, mouse, rat NAPEPLD
      QuantiFast Probe-based Assays in human, mouse, rat NAPEPLD

    Additional mRNA sequence: 

    AB112352.1 AK000801.1 AK023244.1 AK304644.1 AY357337.1 BC037350.2 BC057294.1 BC071604.1 
    CR936639.1 

    12 DOTS entries:

    DT.100686975  DT.100670302  DT.99983730  DT.100710941  DT.101969415  DT.91798318  DT.102842703  DT.422759 
    DT.121073908  DT.121073766  DT.40131984  DT.86841791 

    Selected AceView cDNA sequences (see all 108):

    Z40218 BU169519 AA864799 AB112352 BM148178 AI399802 AA322501 AI369945 
    AI209134 AW445108 AW072626 AI460037 AA360843 CR615836 BU507368 BX091822 
    AY357337 AI864213 AW362038 BQ224588 BU685273 AI815075 AI857635 BG618080 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NAPEPLD    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
    SP1:                                                            
    SP2:        -     -     -                                       
    SP3:                    -                                       


    ECgene alternative splicing isoforms for NAPEPLD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAPEPLD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGGGTTA
    NAPEPLD Expression
    About this image


    NAPEPLD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    NAPEPLD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAPEPLD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.324271
        Custom PCR Arrays for NAPEPLD
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NAPEPLD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPEPLD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAPEPLD gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Napepld1 , 5 N-acyl phosphatidylethanolamine phospholipase D1, 5 83.97(n)1
    89.31(a)1
      5 (9.97 cM)5
    2428641  NM_178728.51  NP_848843.11 
     216629015 
    chicken
    (Gallus gallus)
    Aves NAPEPLD1 N-acyl phosphatidylethanolamine phospholipase D 76.78(n)
    80.98(a)
      417719  NM_001030730.1  NP_001025901.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAPEPLD6
    N-acyl phosphatidylethanolamine phospholipase D
    78(a)
    1 ↔ 1
    5(95316212-95332540)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.339582 Xenopus laevis transcribed sequence with weak similarity more 78.28(n)    CA793413.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc56b112 wufc56b11 74.71(n)   325131  57051008 
    worm
    (Caenorhabditis elegans)
    Secernentea nape-21 nape-2 51.5(n)
    44.58(a)
      177136  NM_171307.3  NP_741361.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FMP30(YPL103C)4 Mitochondrial inner membrane protein with a role in more   --   16(359406-358000) 856001  NP_015222.1 


    ENSEMBL Gene Tree for NAPEPLD (if available)
    TreeFam Gene Tree for NAPEPLD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAPEPLD gene

    Find genes that share paralogs with NAPEPLD           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for NAPEPLD
    PGOHUM00000236354


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAPEPLD (see all 932)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs69501001,2
    H--102740906(+) TTTTTA/TACTAC 2 -- ut314Minor allele frequency- T:0.00NS EA 416
    rs1400730771,2
    --102740946(+) TCCTAC/TGTAGG 2 -- ut310--------
    rs1164337251,2
    C,F--102740955(+) GGTCAC/TGGCAT 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs1443422131,2
    --102740989(+) TTTCTC/TCTAAT 2 -- ut310--------
    rs74559891,2
    H--102741004(+) GACCCA/CCCCTA 2 -- ut31 ese34Minor allele frequency- C:0.00NS EA 420
    rs77838561,2
    C,F,A,H--102741034(+) AAAGTG/ATTCCT 2 -- ut3118Minor allele frequency- A:0.24NS EA NA WA 1558
    rs77843371,2
    C,F,A,H--102741093(+) TTCACA/GAAGAG 2 -- ut31 trp326Minor allele frequency- G:0.22NS NA EA WA 1808
    rs1444841391,2
    C--102741175(+) AGAGAA/TTGGAT 2 -- ut310--------
    rs763757511,2
    C,F--102741177(+) AGAATG/AGATTT 2 -- ut311Minor allele frequency- A:0.03WA 118
    rs37354391,2
    H--102741331(+) AGTGTA/GGAAAG 2 -- ut31 ese34Minor allele frequency- G:0.00NS EA 420

    HapMap Linkage Disequilibrium report for NAPEPLD (102740023 - 102790007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NAPEPLD:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674575CNV Deletion23128226
    nsv5882CNV Insertion18451855
    esv2752138CNV Loss17911159
    nsv831084CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612334    OMIM disorders: --


    Find genes that share disorders with NAPEPLD           About GenesLikeMe

    Genetic Association Database (GAD): NAPEPLD
    Human Genome Epidemiology (HuGE) Navigator: NAPEPLD (1 document)

    Export disorders for NAPEPLD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAPEPLD gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NAPEPLD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PubMed id 15820312)1, 2, 3 Curtiss N.P.... Shannon K.M. (Genomics 2005)
    2. Molecular characterization of a phospholipase D generating anandamide and its congeners. (PubMed id 14634025)1, 2, 3 Okamoto Y.... Ueda N. (J. Biol. Chem. 2004)
    3. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. (PubMed id 18067139)1, 3 EgertovA! M....Elphick M.R. (J. Comp. Neurol. 2008)
    4. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PubMed id 23080069)1 Esteves S.L....da Cruz e Silva E.F. (J. Mol. Neurosci. 2013)
    5. Differential expression of endocannabinoid system in normal and preeclamptic placentas: effects on nitric oxide synthesis. (PubMed id 23122699)1 AbA!n C....Farina M.G. (Placenta 2013)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. (PubMed id 22827915)1 Long L.E....Weickert C.S. (BMC Neurosci 2012)
    8. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Cannabinoid receptor and N-acyl phosphatidylethanolamine phospholipase D--evidence for altered expression in multiple sclerosis. (PubMed id 21251115)1 Zhang H....Zajicek J. (Brain Pathol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 222236 HGNC: 21683 AceView: NAPE-PLD Ensembl:ENSG00000161048 euGenes: HUgn222236
    ECgene: NAPEPLD Kegg: 222236 H-InvDB: NAPEPLD

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NAPEPLD Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/N-acyl_phosphatidylethanolamine-specific_phospholipase_D

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAPEPLD gene:
    Search GeneIP for patents involving NAPEPLD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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