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Aliases & Descriptions for NAPEPLD
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases C7orf18 1 , 3 DKFZp781D1098 2 EC 3.1.4.- 3 FMP30 1 , 2 NAPE-PLD 1 , 2 , 3
Descriptions N-acyl phosphatidylethanolamine phospholipase D 2 , 3 N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D 2 NAPE-hydrolyzing phospholipase D 3
Search outside databases for aliases for NAPEPLD gene
Summaries for NAPEPLD (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for NAPEPLD : NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE)from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis ofN-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM] UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20 Function : Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs)and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine),the ligand of cannabinoid and vanilloid receptors (By similarity)
Genomic Location for NAPEPLD
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22.1 NAPEPLD Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure
GeneLoc location for GC07M102528:
(about GC identifiers )
Start:
102,527,459 bp from pter
End:
102,576,749 bp from pter
Size:
49,291 bases
Orientation:
minus strand
1 alternative location : Chr 7-,CRA_TCAG 102,100,589-102,149,871
RefSeq DNA sequence: NC_000007.12 NT_007933.14 NT_079596.2 Proteins for NAPEPLD
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20 (See
protein sequence )Recommended Name: N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D Size : 393 amino acids; 45596 Da
Cofactor : Binds 1 or 2 zinc ions per subunit (By similarity)
Subunit : Monomer (By similarity)
Subcellular location : Membrane (By similarity)
Secondary accessions : Q5CZ87 Q769K1
REFSEQ proteins (2 alternative transcripts):
NP_001116310.1 NP_945341.3 ENSEMBL proteins: ENSP00000340093 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: NAPEPLD 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA --
About this table Antibodies for NAPEPLD: Assays for NAPEPLD:
Protein
Domains/ Families for NAPEPLD(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q6IQ20
UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20 Similarity : Belongs to the NAPE-PLD family
Gene Function for NAPEPLD
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): XM_168636 Applied Biosystems Silencer ® siRNAs for NAPEPLD Sigma-Aldrich siRNA for NAPEPLD Sigma-Aldrich shRNA for NAPEPLD Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001122838                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001122838                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001122838  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_198990 UniProtKB/Swiss-Prot: NAPEP_HUMAN, Q6IQ20 Function : Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs)and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine),the ligand of cannabinoid and vanilloid receptors (By similarity) Enzyme regulation : Activity is stimulated by divalent cations (By similarity)Enzyme Number (IUBMB): EC 3.1.4.-
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Napepld) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for NAPEPLD
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5 Sigma-Aldrich "Your Favorite Gene" Pathways for NAPEPLD (Your Favorite Gene powered by Ingenuity) 5/6 Interacting proteins for NAPEPLD (ENSP00000340093 3 ) via UniProtKB, MINT, and/or STRING (see all 6
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006629 lipid metabolic process
IEA -- GO:0009395 phospholipid catabolic process
IEA --
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Drugs & Compounds for NAPEPLD (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for NAPEPLD
Transcripts for NAPEPLD(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): XM_168636 Sigma-Aldrich siRNA for NAPEPLD Sigma-Aldrich shRNA for NAPEPLD Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001122838 NM_198990
REFSEQ mRNAs for NAPEPLD gene (2 alternative transcripts): NM_001122838.1 NM_198990.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001122838 NM_198990
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001122838                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001122838                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001122838  
Additional cDNA sequence: AB112352.1 AK000801.1 AK023244.1 AK304644.1 AY357337.1 BC037350.2 BC057294.1 BC071604.1 CR615836.1 CR936639.1
12 DOTS entries : DT.100686975 DT.100670302 DT.99983730 DT.100710941 DT.91798318 DT.101969415 DT.102842703 DT.422759 DT.121073908 DT.121073766 DT.40131984 DT.86841791
24/108 AceView cDNA sequences (see all 108
):AA322501 BU169519 Z40218 BX091822 AI460037 AB112352 CR615836 AI209134 BM148178 AW072626 AY357337 AA864799 AW445108 AA360843 AI399802 AI369945 BU507368 N78417 BG742468 AI435063 H29395 BG426843 BQ025325 BQ214521
Unigene Cluster for NAPEPLD: N-acyl phosphatidylethanolamine phospholipase D Hs.324271 [show with all ESTs ] Unigene Representative Sequence: NM_001122838 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for NAPEPLD ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 SP1 :                     SP2 :   -   -   -               SP3 :       -              
About this scheme ECgene alternative splicing isoforms for NAPEPLD 1 Ensembl transcript including schematic representation : ENST00000341533
Expression for NAPEPLD
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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NAPEPLD expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for NAPEPLD 1 / 2
13 probe-sets matching NAPEPLD gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCAGGGGTTASOURCE GeneReport for Unigene cluster: Hs.324271
Orthologs for NAPEPLD
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for NAPEPLD gene from 5/14 species (see all 14
)
About this table Species with no ortholog for NAPEPLD ENSEMBL Gene Tree for NAPEPLD Paralogs for NAPEPLD (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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--
SNPs/Variants for NAPEPLD (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for NAPEPLD (up to first 250kb)
Disorders & Mutations for NAPEPLD
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 612334
Medical News for NAPEPLD (Possibly Related Articles in
Doctor's Guide )
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Publications for NAPEPLD (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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8 PubMed articles for NAPEPLD gene :
Search for NAPEPLD
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NAPEPLD
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing NAPEPLD
(According to HUGE )
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Specialized Databases showing NAPEPLD (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
Wikipedia http://en.wikipedia.org/wiki/N-acyl_phosphatidylethanolamine-specific_phospholipase_D
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-- Services for NAPEPLD (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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