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Aliases for NAPEPLD Gene

Aliases for NAPEPLD Gene

  • N-Acyl Phosphatidylethanolamine Phospholipase D 2 3 4
  • N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D 2 3
  • NAPE-Hydrolyzing Phospholipase D 3 4
  • NAPE-PLD 3 4
  • Chromosome 7 Open Reading Frame 18 2
  • EC 3.1.4.54 4
  • EC 3.1.4 64
  • C7orf18 4
  • FMP30 3

External Ids for NAPEPLD Gene

Summaries for NAPEPLD Gene

Entrez Gene Summary for NAPEPLD Gene

  • NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

GeneCards Summary for NAPEPLD Gene

NAPEPLD (N-Acyl Phosphatidylethanolamine Phospholipase D) is a Protein Coding gene. Among its related pathways are Disease and Diseases associated with visual transduction. GO annotations related to this gene include N-acylphosphatidylethanolamine-specific phospholipase D activity.

UniProtKB/Swiss-Prot for NAPEPLD Gene

  • Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPEPLD Gene

Genomics for NAPEPLD Gene

Genomic Location for NAPEPLD Gene

Start:
103,099,576 bp from pter
End:
103,150,631 bp from pter
Size:
51,056 bases
Orientation:
Minus strand

Genomic View for NAPEPLD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPEPLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPEPLD Gene

Regulatory Elements for NAPEPLD Gene

Proteins for NAPEPLD Gene

  • Protein details for NAPEPLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ20-NAPEP_HUMAN
    Recommended name:
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
    Protein Accession:
    Q6IQ20
    Secondary Accessions:
    • Q5CZ87
    • Q769K1

    Protein attributes for NAPEPLD Gene

    Size:
    393 amino acids
    Molecular mass:
    45596 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 or 2 zinc ions per subunit.;
    Quaternary structure:
    • Monomer.

neXtProt entry for NAPEPLD Gene

Proteomics data for NAPEPLD Gene at MOPED

Post-translational modifications for NAPEPLD Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys73 and Lys296

Other Protein References for NAPEPLD Gene

Domains for NAPEPLD Gene

Protein Domains for NAPEPLD Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NAPEP_HUMAN
Family:
  • Belongs to the NAPE-PLD family.:
    • Q6IQ20
genes like me logo Genes that share domains with NAPEPLD: view

Function for NAPEPLD Gene

Molecular function for NAPEPLD Gene

UniProtKB/Swiss-Prot CatalyticActivity: An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is stimulated by divalent cations.
UniProtKB/Swiss-Prot Function: Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).

Enzyme Numbers (IUBMB) for NAPEPLD Gene

Gene Ontology (GO) - Molecular Function for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity --
GO:0008270 zinc ion binding IEA --
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity IEA --
genes like me logo Genes that share ontologies with NAPEPLD: view

Phenotypes for NAPEPLD Gene

genes like me logo Genes that share phenotypes with NAPEPLD: view

Animal Models for NAPEPLD Gene

MGI Knock Outs for NAPEPLD:

miRNA for NAPEPLD Gene

miRTarBase miRNAs that target NAPEPLD

No data available for Transcription Factor Targeting and HOMER Transcription for NAPEPLD Gene

Localization for NAPEPLD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPEPLD Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPEPLD Gene COMPARTMENTS Subcellular localization image for NAPEPLD gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0042622 photoreceptor outer segment membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAPEPLD: view

Pathways for NAPEPLD Gene

genes like me logo Genes that share pathways with NAPEPLD: view

Pathways by source for NAPEPLD Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for NAPEPLD Gene
1 KEGG pathway for NAPEPLD Gene

Gene Ontology (GO) - Biological Process for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0007603 phototransduction, visible light TAS --
GO:0009395 phospholipid catabolic process IEA --
genes like me logo Genes that share ontologies with NAPEPLD: view

Compounds for NAPEPLD Gene

(1088) HMDB Compounds for NAPEPLD Gene

Compound Synonyms Cas Number PubMed IDs
Anandamide
  • Anandamide (20.4, n-6)
94421-68-8
PA(16:0/16:0)
  • Dipalmitoylphosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • PA(16:0/18:1n7)
Not Available
PA(16:0/18:1(9Z))
  • PA(16:0/18:1n9)
Not Available
PA(16:0/18:2(9Z,12Z))
  • PA(34:2)
Not Available
genes like me logo Genes that share compounds with NAPEPLD: view

Transcripts for NAPEPLD Gene

Unigene Clusters for NAPEPLD Gene

N-acyl phosphatidylethanolamine phospholipase D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPEPLD Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1:
SP2: - - -
SP3: -

Relevant External Links for NAPEPLD Gene

GeneLoc Exon Structure for
NAPEPLD
ECgene alternative splicing isoforms for
NAPEPLD

Expression for NAPEPLD Gene

mRNA expression in normal human tissues for NAPEPLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NAPEPLD Gene

SOURCE GeneReport for Unigene cluster for NAPEPLD Gene Hs.324271

genes like me logo Genes that share expressions with NAPEPLD: view

Orthologs for NAPEPLD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPEPLD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPEPLD 36
  • 99.41 (n)
  • 98.98 (a)
NAPEPLD 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAPEPLD 36
  • 88.29 (n)
  • 90.77 (a)
NAPEPLD 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPEPLD 36
  • 79.55 (n)
  • 86.08 (a)
NAPEPLD 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napepld 36
  • 83.97 (n)
  • 89.31 (a)
Napepld 16
Napepld 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAPEPLD 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPEPLD 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napepld 36
  • 83.97 (n)
  • 90.59 (a)
chicken
(Gallus gallus)
Aves NAPEPLD 36
  • 76.78 (n)
  • 80.98 (a)
NAPEPLD 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAPEPLD 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33958 36
tropical clawed frog
(Silurana tropicalis)
Amphibia napepld 36
  • 72.96 (n)
  • 76.02 (a)
Str.17648 36
zebrafish
(Danio rerio)
Actinopterygii napepld 36
  • 64.1 (n)
  • 64.67 (a)
napepld 37
  • 55 (a)
OneToOne
wufc56b11 36
worm
(Caenorhabditis elegans)
Secernentea nape-1 37
  • 41 (a)
OneToMany
nape-2 36
  • 51.5 (n)
  • 44.58 (a)
nape-2 37
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP30 37
  • 26 (a)
OneToOne
FMP30 39
bread mold
(Neurospora crassa)
Ascomycetes NCU07271 36
  • 48.96 (n)
  • 43.59 (a)
Species with no ortholog for NAPEPLD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPEPLD Gene

ENSEMBL:
Gene Tree for NAPEPLD (if available)
TreeFam:
Gene Tree for NAPEPLD (if available)

Paralogs for NAPEPLD Gene

Pseudogenes.org Pseudogenes for NAPEPLD Gene

genes like me logo Genes that share paralogs with NAPEPLD: view

No data available for Paralogs for NAPEPLD Gene

Variants for NAPEPLD Gene

Sequence variations from dbSNP and Humsavar for NAPEPLD Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs952521 -- 103,130,762(+) GGCTA(A/G)TTTTT intron-variant, upstream-variant-2KB
rs1064843 -- 103,118,329(+) AATTA(G/T)AAAAG intron-variant
rs1477159 -- 103,139,192(-) TTACA(A/G)GTAAT intron-variant
rs1477160 -- 103,138,445(-) AAAGT(G/T)GGAAC intron-variant
rs1477161 -- 103,138,419(-) AAGAA(G/T)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAPEPLD Gene

Variant ID Type Subtype PubMed ID
esv2752138 CNV Loss 17911159
esv2674575 CNV Deletion 23128226
nsv831084 CNV Gain 17160897
nsv5882 CNV Insertion 18451855

Relevant External Links for NAPEPLD Gene

HapMap Linkage Disequilibrium report
NAPEPLD

Disorders for NAPEPLD Gene

Relevant External Links for NAPEPLD

Genetic Association Database (GAD)
NAPEPLD
Human Genome Epidemiology (HuGE) Navigator
NAPEPLD
genes like me logo Genes that share disorders with NAPEPLD: view

No data available for UniProtKB/Swiss-Prot for NAPEPLD Gene

Publications for NAPEPLD Gene

  1. Molecular characterization of a phospholipase D generating anandamide and its congeners. (PMID: 14634025) Okamoto Y. … Ueda N. (J. Biol. Chem. 2004) 2 3 4
  2. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss N.P. … Shannon K.M. (Genomics 2005) 2 3 4
  3. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. (PMID: 18067139) EgertovA! M. … Elphick M.R. (J. Comp. Neurol. 2008) 2 3
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  5. Effect of synthetic and natural phospholipids on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D activity. (PMID: 19715685) Petersen G. … Hansen H.S. (Chem. Phys. Lipids 2009) 3

Products for NAPEPLD Gene

Sources for NAPEPLD Gene

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