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Aliases for NAPEPLD Gene

Aliases for NAPEPLD Gene

  • N-Acyl Phosphatidylethanolamine Phospholipase D 2 3 4 5
  • NAPE-Hydrolyzing Phospholipase D 3 4
  • NAPE-PLD 3 4
  • N-Acyl-Phosphatidylethanolamine-Hydrolyzing Phospholipase D 2
  • Chromosome 7 Open Reading Frame 18 2
  • EC 3.1.4.54 4
  • EC 3.1.4 63
  • C7orf18 4
  • FMP30 3

External Ids for NAPEPLD Gene

Previous GeneCards Identifiers for NAPEPLD Gene

  • GC07M102528
  • GC07M102742
  • GC07M097103

Summaries for NAPEPLD Gene

Entrez Gene Summary for NAPEPLD Gene

  • NAPEPLD is a phospholipase D type enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE) in the second step of the biosynthesis of N-acylethanolamine (Okamoto et al., 2004 [PubMed 14634025]).[supplied by OMIM, Oct 2008]

GeneCards Summary for NAPEPLD Gene

NAPEPLD (N-Acyl Phosphatidylethanolamine Phospholipase D) is a Protein Coding gene. Among its related pathways are Circadian entrainment and Diseases associated with visual transduction. GO annotations related to this gene include phospholipase activity and N-acylphosphatidylethanolamine-specific phospholipase D activity.

UniProtKB/Swiss-Prot for NAPEPLD Gene

  • Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPEPLD Gene

Genomics for NAPEPLD Gene

Regulatory Elements for NAPEPLD Gene

Enhancers for NAPEPLD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NAPEPLD on UCSC Golden Path with GeneCards custom track

Promoters for NAPEPLD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAPEPLD on UCSC Golden Path with GeneCards custom track

Genomic Location for NAPEPLD Gene

Chromosome:
7
Start:
103,099,576 bp from pter
End:
103,149,560 bp from pter
Size:
49,985 bases
Orientation:
Minus strand

Genomic View for NAPEPLD Gene

Genes around NAPEPLD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPEPLD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPEPLD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPEPLD Gene

Proteins for NAPEPLD Gene

  • Protein details for NAPEPLD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ20-NAPEP_HUMAN
    Recommended name:
    N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
    Protein Accession:
    Q6IQ20
    Secondary Accessions:
    • Q5CZ87
    • Q769K1

    Protein attributes for NAPEPLD Gene

    Size:
    393 amino acids
    Molecular mass:
    45596 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NAPEPLD Gene

neXtProt entry for NAPEPLD Gene

Proteomics data for NAPEPLD Gene at MOPED

Post-translational modifications for NAPEPLD Gene

  • Ubiquitination at Lys 73 and Lys 296
  • Modification sites at PhosphoSitePlus

Domains & Families for NAPEPLD Gene

Gene Families for NAPEPLD Gene

Protein Domains for NAPEPLD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NAPEPLD Gene

Graphical View of Domain Structure for InterPro Entry

Q6IQ20

UniProtKB/Swiss-Prot:

NAPEP_HUMAN :
  • Belongs to the NAPE-PLD family.
Family:
  • Belongs to the NAPE-PLD family.
genes like me logo Genes that share domains with NAPEPLD: view

Function for NAPEPLD Gene

Molecular function for NAPEPLD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An N-acylphosphatidylethanolamine + H(2)O = an N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity is stimulated by divalent cations.
UniProtKB/Swiss-Prot Function:
Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).

Enzyme Numbers (IUBMB) for NAPEPLD Gene

genes like me logo Genes that share phenotypes with NAPEPLD: view

Animal Models for NAPEPLD Gene

MGI Knock Outs for NAPEPLD:

Animal Model Products

  • Taconic Biosciences Mouse Models for NAPEPLD

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NAPEPLD Gene

Localization for NAPEPLD Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPEPLD Gene

Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPEPLD Gene COMPARTMENTS Subcellular localization image for NAPEPLD gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 4
nucleus 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NAPEPLD: view

Pathways & Interactions for NAPEPLD Gene

genes like me logo Genes that share pathways with NAPEPLD: view

Pathways by source for NAPEPLD Gene

Gene Ontology (GO) - Biological Process for NAPEPLD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009395 phospholipid catabolic process IEA --
genes like me logo Genes that share ontologies with NAPEPLD: view

No data available for SIGNOR curated interactions for NAPEPLD Gene

Drugs & Compounds for NAPEPLD Gene

(1) Drugs for NAPEPLD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Anandamide Pharma Antagonist, Pore Blocker 0

(17) Additional Compounds for NAPEPLD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PA(16:0/16:0)
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate
  • 1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid
  • 1,2-Dihexadecanoyl-rac-phosphatidic acid
  • 1,2-Dipalmitoyl-3-sn-phosphatidate
  • 1,2-Dipalmitoyl-3-sn-phosphatidic acid
7091-44-3
PA(16:0/18:1(11Z))
  • 1-Hexadecanoyl-2-(11Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-vaccenoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n7)
  • PA(16:0/18:1w7)
PA(16:0/18:1(9Z))
  • 1-Hexadecanoyl-2-(9Z-octadecenoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:1)
  • PA(16:0/18:1n9)
  • PA(16:0/18:1w9)
PA(16:0/18:2(9Z,12Z))
  • 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-phosphatidic acid
  • 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphate
  • PA(16:0/18:2)
  • PA(16:0/18:2n6)
  • PA(16:0/18:2w6)
PA(16:0e/18:0)
  • 2-Octadecanoyl-1-hexadecyl-sn-glycero-3-phosphate
  • PA(O-16:0/18:0)
genes like me logo Genes that share compounds with NAPEPLD: view

Transcripts for NAPEPLD Gene

Unigene Clusters for NAPEPLD Gene

N-acyl phosphatidylethanolamine phospholipase D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPEPLD Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1:
SP2: - - -
SP3: -

Relevant External Links for NAPEPLD Gene

GeneLoc Exon Structure for
NAPEPLD
ECgene alternative splicing isoforms for
NAPEPLD

Expression for NAPEPLD Gene

mRNA expression in normal human tissues for NAPEPLD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPEPLD Gene

This gene is overexpressed in Frontal cortex (28.0), Bone marrow mesenchymal stem cell (12.6), Brain (8.3), and Adipocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAPEPLD Gene



SOURCE GeneReport for Unigene cluster for NAPEPLD Gene Hs.324271

genes like me logo Genes that share expression patterns with NAPEPLD: view

Protein tissue co-expression partners for NAPEPLD Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPEPLD Gene

Orthologs for NAPEPLD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPEPLD Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAPEPLD 35
  • 88.29 (n)
  • 90.77 (a)
NAPEPLD 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPEPLD 35
  • 79.55 (n)
  • 86.08 (a)
NAPEPLD 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napepld 35
  • 83.97 (n)
  • 89.31 (a)
Napepld 16
Napepld 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAPEPLD 35
  • 99.41 (n)
  • 98.98 (a)
NAPEPLD 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napepld 35
  • 83.97 (n)
  • 90.59 (a)
oppossum
(Monodelphis domestica)
Mammalia NAPEPLD 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NAPEPLD 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves NAPEPLD 35
  • 76.78 (n)
  • 80.98 (a)
NAPEPLD 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAPEPLD 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia napepld 35
  • 72.96 (n)
  • 76.02 (a)
Str.17648 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33958 35
zebrafish
(Danio rerio)
Actinopterygii napepld 35
  • 64.1 (n)
  • 64.67 (a)
wufc56b11 35
napepld 36
  • 55 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nape-2 35
  • 51.5 (n)
  • 44.58 (a)
nape-1 36
  • 41 (a)
OneToMany
nape-2 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FMP30 36
  • 26 (a)
OneToOne
FMP30 38
bread mold
(Neurospora crassa)
Ascomycetes NCU07271 35
  • 48.96 (n)
  • 43.59 (a)
Species with no ortholog for NAPEPLD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPEPLD Gene

ENSEMBL:
Gene Tree for NAPEPLD (if available)
TreeFam:
Gene Tree for NAPEPLD (if available)

Paralogs for NAPEPLD Gene

Pseudogenes.org Pseudogenes for NAPEPLD Gene

genes like me logo Genes that share paralogs with NAPEPLD: view

No data available for Paralogs for NAPEPLD Gene

Variants for NAPEPLD Gene

Sequence variations from dbSNP and Humsavar for NAPEPLD Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3181009 - 103,103,446(-) ATAAT(A/G)ATGAT reference, missense
rs12540583 - 103,120,064(+) ACGAG(A/C)GCTAA reference, missense
rs952521 -- 103,130,762(+) GGCTA(A/G)TTTTT intron-variant
rs6947777 -- 103,133,146(+) TAACC(C/T)TACCC intron-variant
rs6950100 -- 103,100,459(+) TTTTT(A/T)ACTAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NAPEPLD Gene

Variant ID Type Subtype PubMed ID
esv2752138 CNV Loss 17911159
esv2674575 CNV Deletion 23128226
nsv831084 CNV Gain 17160897
nsv5882 CNV Insertion 18451855

Variation tolerance for NAPEPLD Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPEPLD Gene

HapMap Linkage Disequilibrium report
NAPEPLD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPEPLD Gene

Disorders for NAPEPLD Gene

Relevant External Links for NAPEPLD

Genetic Association Database (GAD)
NAPEPLD
Human Genome Epidemiology (HuGE) Navigator
NAPEPLD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPEPLD

No disorders were found for NAPEPLD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPEPLD Gene

Publications for NAPEPLD Gene

  1. Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. (PMID: 15820312) Curtiss N.P. … Shannon K.M. (Genomics 2005) 2 3 4 67
  2. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. (PMID: 18067139) EgertovA! M. … Elphick M.R. (J. Comp. Neurol. 2008) 2 3
  3. Molecular characterization of a phospholipase D generating anandamide and its congeners. (PMID: 14634025) Okamoto Y. … Ueda N. (J. Biol. Chem. 2004) 2 3
  4. Structure of human N-acylphosphatidylethanolamine-hydrolyzing phospholipase D: regulation of fatty acid ethanolamide biosynthesis by bile acids. (PMID: 25684574) Magotti P. … Garau G. (Structure 2015) 3
  5. Protein phosphatase 1I^ isoforms linked interactions in the brain. (PMID: 23080069) Esteves S.L. … da Cruz e Silva E.F. (J. Mol. Neurosci. 2013) 3

Products for NAPEPLD Gene

Sources for NAPEPLD Gene

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