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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAPB Gene

protein-coding   GIFtS: 51
GCID: GC20M023355

N-Ethylmaleimide-Sensitive Factor Attachment Protein, Beta

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Ethylmaleimide-Sensitive Factor Attachment Protein, Beta1 2
SNAPB2 3
SNAP-BETA2
Beta-Soluble NSF Attachment Protein2
SNAP-beta3
N-Ethylmaleimide-Sensitive Factor Attachment Protein Beta3

External Ids:    HGNC: 157511   Entrez Gene: 639082   Ensembl: ENSG000001258147   OMIM: 6112705   UniProtKB: Q9H1153   

Export aliases for NAPB gene to outside databases

Previous GC identifers: GC17U990129 GC20M023303 GC20M023350 GC20M023319


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NAPB Gene: 
NAPB (N-ethylmaleimide-sensitive factor attachment protein, beta) is a protein-coding gene. Diseases associated with NAPB include hyperargininemia. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is NAPA.

UniProtKB/Swiss-Prot: SNAB_HUMAN, Q9H115
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By
similarity)

Gene Wiki entry for NAPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011387.8  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAPB gene promoter:
         STAT1   RREB-1   STAT1beta   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   RelA   STAT1alpha   AREB6   ATF6   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAPB promoter sequence
   Search SABiosciences Chromatin IP Primers for NAPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.3-p11.21   Ensembl cytogenetic band:  20p11.21   HGNC cytogenetic band: 20p12.3-p11.21

NAPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M023355:  view genomic region     (about GC identifiers)

Start:
23,355,156 bp from pter      End:
23,402,156 bp from pter
Size:
47,001 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNAB_HUMAN, Q9H115 (See protein sequence)
Recommended Name: Beta-soluble NSF attachment protein  
Size: 298 amino acids; 33557 Da
Subunit: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the
internalization of GRIA2 (By similarity)
Subcellular location: Membrane; Peripheral membrane protein (By similarity)
Secondary accessions: Q4G187 Q5JXF9 Q8N3C4

Explore the universe of human proteins at neXtProt for NAPB: NX_Q9H115

Explore proteomics data for NAPB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H115

  • NAPB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAPB Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001269947.1  NP_001269949.1  NP_001269955.1  NP_071363.1  

    ENSEMBL proteins: 
     ENSP00000366225   ENSP00000413600   ENSP00000381459  

    Human Recombinant Protein Products for NAPB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NAPB
    OriGene Protein Over-expression Lysate for NAPB
    OriGene MassSpec for NAPB 
    OriGene Custom Protein Services for NAPB
    GenScript Custom Purified and Recombinant Proteins Services for NAPB
    Novus Biologicals NAPB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA--

    NAPB for ontologies           About GeneDecksing



    NAPB Antibody Products: 
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    Assay Products for NAPB: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NAPB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000744 NSF_attach
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry Q9H115

    ProtoNet protein and cluster: Q9H115

    1 Blocks protein domain: IPB000744 NSF attachment protein signature

    UniProtKB/Swiss-Prot: SNAB_HUMAN, Q9H115
    Similarity: Belongs to the SNAP family


    NAPB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNAB_HUMAN, Q9H115
    Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (By
    similarity)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0019905syntaxin binding IEA--
         
    NAPB for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Napb):
     behavior/neurological  mortality/aging  nervous system 

    NAPB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Napbtm1Rhee for NAPB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAPB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NAPB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAPB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAPB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAPB
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NAPB (see all 30):
    hsa-miR-448 hsa-miR-607 hsa-miR-3607-5p hsa-miR-429 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-513c
    SwitchGear 3'UTR luciferase reporter plasmidNAPB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAPB
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NAPB

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NAPB (see all 7)
    OriGene ORF clones in mouse, rat for NAPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAPB (NM_022080)
    Sino Biological Human cDNA Clone for NAPB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPB
    Sirion Biotech Customized lentivirus for stable overexpression of NAPB 
                         Customized lentivirus expression plasmids for stable overexpression of NAPB 

    Cell Line
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    Search LifeMap BioReagents cell lines for NAPB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/86 Interacting proteins for NAPB (Q9H1153 ENSP000003662254) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464593, ENSP000003812934I2D: score=4 STRING: ENSP00000381293
    BNIP1Q129813, ENSP000002316684I2D: score=1 STRING: ENSP00000231668
    STX12Q86Y823, ENSP000003630544I2D: score=1 STRING: ENSP00000363054
    YKT6O154983, ENSP000002233694I2D: score=2 STRING: ENSP00000223369
    SCFD1Q8WVM83, ENSP000003907834I2D: score=4 STRING: ENSP00000390783
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0010807regulation of synaptic vesicle priming IEA--
    GO:0035249synaptic transmission, glutamatergic IEA--
    GO:0035494SNARE complex disassembly IEA--

    NAPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAPB (SNAB)

    Search CenterWatch for drugs/clinical trials and news about NAPB / SNAB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NAPB gene (4 alternative transcripts): 
    NM_001283018.1  NM_001283020.1  NM_001283026.1  NM_022080.2  

    Unigene Cluster for NAPB:

    N-ethylmaleimide-sensitive factor attachment protein, beta
    Hs.269471  [show with all ESTs]
    Unigene Representative Sequence: NM_022080
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377026(uc010zss.1 uc002wta.3 uc002wtc.3 uc002wtb.3 uc002wtd.4 uc010zst.1)
    ENST00000472855 ENST00000468128 ENST00000487502 ENST00000432543 ENST00000398425

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAPB
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate NAPB (see all 30):
    hsa-miR-448 hsa-miR-607 hsa-miR-3607-5p hsa-miR-429 hsa-miR-29c hsa-miR-29a hsa-miR-767-5p hsa-miR-513c
    SwitchGear 3'UTR luciferase reporter plasmidNAPB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NAPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPB
    Clone
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    OriGene clones in human, mouse for NAPB (see all 7)
    OriGene ORF clones in mouse, rat for NAPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAPB (NM_022080)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPB
    Sirion Biotech Customized lentivirus for stable overexpression of NAPB 
                         Customized lentivirus expression plasmids for stable overexpression of NAPB 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NAPB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAPB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAPB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPB

    Additional mRNA sequence: 

    AK022817.1 AK124876.1 AK294703.1 AK295791.1 AK296385.1 AK307709.1 AL834445.1 BC008463.1 
    BC026310.1 BC047426.1 BC060840.1 BX648330.1 

    15 DOTS entries:

    DT.449099  DT.101983121  DT.101983122  DT.99946862  DT.101983124  DT.100031457  DT.100781796  DT.97786086 
    DT.120839147  DT.97842873  DT.120839158  DT.120839159  DT.120839173  DT.120839174  DT.120839182 

    24/203 AceView cDNA sequences (see all 203):

    F09971 BQ694031 BM704222 CB069717 BE327058 AA975324 AK124876 AA953489 
    AI305251 F13158 T33462 CB127322 BM930893 BU184334 AI306486 BM717893 
    CK819291 AI278427 AW207670 T31188 AA351671 BM699534 H91664 AL834445 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NAPB (see all 16)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
    SP1:                                      -                 -     -     -                                         -                 -                 -         
    SP2:                                      -     -           -     -     -                                         -                 -                 -         
    SP3:                                      -     -           -     -     -     -                                   -                 -                 -         
    SP4:                                      -     -           -     -     -     -                                   -                 -                 -         
    SP5:                                                                                                              -                 -                 -         

    ExUns: 13b · 13c · 13d
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NAPB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAPB expression in normal human tissues (normalized intensities)      NAPB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAACAATA
    NAPB Expression
    About this image


    NAPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Ovary (Reproductive System)

    See NAPB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAPB

    SOURCE GeneReport for Unigene cluster: Hs.269471
        SABiosciences Custom PCR Arrays for NAPB
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NAPB
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAPB gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Napb1 , 5 N-ethylmaleimide sensitive fusion protein attachment more1, 5 91.16(n)1
    100(a)1
      2 (73.53 cM)5
    179571  NM_019632.31  NP_062606.11 
     1486939855 
    chicken
    (Gallus gallus)
    Aves NAPB1 N-ethylmaleimide-sensitive factor attachment protein, more 83(n)
    96.96(a)
      421231  NM_001199430.1  NP_001186359.1 
    lizard
    (Anolis carolinensis)
    Reptilia NAPB6
    Uncharacterized protein
    91(a)
    1 ↔ 1
    1(129678337-129708573)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.155672 Transcribed sequence with moderate similarity to protein more 78.75(n)    BX720447.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1586431 zgc:158643 78.76(n)
    87.46(a)
      791220  NM_001080702.1  NP_001074171.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Snap3 ER to Golgi transport soluble NSF
    attachment protein
    63(a)   3 77B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea D1014.33 alpha-SNAP protein 50(a)   V(8132963-8135654)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC17(YBL050W)4 Peripheral membrane protein required for vesicular more   --   2(125125-126119) 852230  NP_009503.1 


    ENSEMBL Gene Tree for NAPB (if available)
    TreeFam Gene Tree for NAPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAPB gene
    NAPA2  
    1 SIMAP similar gene for NAPB using alignment to 3 protein entries:     SNAB_HUMAN (see all proteins):
    NAPA

    NAPB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1092 SNPs in NAPB are shown (see all 1092)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887317571,2
    --23354716(+) AAATTA/CAAATA 1 -- ds50010--------
    rs22528241,2
    C,F,O,A,H--23354748(+) GTTGAG/ATGGTA 1 -- ds500126Minor allele frequency- A:0.28EA NS NA WA 4232
    rs1403867971,2
    --23354761(+) TTCTTA/GGGGTA 1 -- ds50010--------
    rs61326051,2
    C,F,A,H--23354839(+) TTTGCA/CAGTAA 1 -- ds500112Minor allele frequency- C:0.16NS EA NA 794
    rs1149665301,2
    C,F--23354975(+) CATTAC/TGGTGC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1455893071,2
    --23354976(+) ATTACA/GGTGCC 1 -- ds50010--------
    rs1510356711,2
    --23355120(+) TACTGA/GTAATT 1 -- ds50010--------
    rs60830961,2
    C--23355171(+) GCTAAA/GGTAGA 1 -- ut310--------
    rs60830971,2
    H--23355234(+) ACTCAG/AGACTC 1 -- ut31 ese34Minor allele frequency- A:0.00NS EA 418
    rs758625241,2
    C--23355295(+) GTCACA/GGGGGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NAPB (23355156 - 23402156 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NAPB: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NAPB
    DNA2.0 Custom Variant and Variant Library Synthesis for NAPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611270    OMIM disorders: --

    2 diseases for NAPB:    About MalaCards
    hyperargininemia    


    NAPB for disorders           About GeneDecksing


    Export disorders for NAPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAPB gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with NAPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    3. SNAP family of NSF attachment proteins includes a brain-specific isoform. (PubMed id 8455721)1, 3 Whiteheart S.W....Rothman J.E. (1993)
    4. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. (PubMed id 9697855)1, 9 Osten P....Ziff E.B. (1998)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. (PubMed id 20639865)1 Xu G....Jaffrey S.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63908 HGNC: 15751 AceView: NAPB Ensembl:ENSG00000125814 euGenes: HUgn63908
    ECgene: NAPB H-InvDB: NAPB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAPB gene:
    Search GeneIP for patents involving NAPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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