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Aliases for NAPB Gene

Aliases for NAPB Gene

  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Beta 2 3
  • SNAP-BETA 3 4
  • SNAPB 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Beta 4

External Ids for NAPB Gene

Previous GeneCards Identifiers for NAPB Gene

  • GC17U990129
  • GC20M023303
  • GC20M023350
  • GC20M023319
  • GC20M023355

Summaries for NAPB Gene

GeneCards Summary for NAPB Gene

NAPB (N-Ethylmaleimide-Sensitive Factor Attachment Protein, Beta) is a Protein Coding gene. Diseases associated with NAPB include amyotrophy, hereditary neuralgic. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPA.

UniProtKB/Swiss-Prot for NAPB Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPB Gene

Genomics for NAPB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NAPB Gene

Chromosome:
20
Start:
23,374,519 bp from pter
End:
23,421,519 bp from pter
Size:
47,001 bases
Orientation:
Minus strand

Genomic View for NAPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPB Gene

Proteins for NAPB Gene

  • Protein details for NAPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H115-SNAB_HUMAN
    Recommended name:
    Beta-soluble NSF attachment protein
    Protein Accession:
    Q9H115
    Secondary Accessions:
    • B4DK44
    • Q4G0M0
    • Q4G187
    • Q5JXF9
    • Q8N3C4

    Protein attributes for NAPB Gene

    Size:
    298 amino acids
    Molecular mass:
    33557 Da
    Quaternary structure:
    • Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.

    Alternative splice isoforms for NAPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NAPB Gene

Proteomics data for NAPB Gene at MOPED

Post-translational modifications for NAPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NAPB Gene

No data available for DME Specific Peptides for NAPB Gene

Domains & Families for NAPB Gene

Protein Domains for NAPB Gene

Graphical View of Domain Structure for InterPro Entry

Q9H115

UniProtKB/Swiss-Prot:

SNAB_HUMAN :
  • Belongs to the SNAP family.
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPB: view

No data available for Gene Families for NAPB Gene

Function for NAPB Gene

Molecular function for NAPB Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for NAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005483 soluble NSF attachment protein activity IBA --
GO:0005515 protein binding IPI 21516116
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with NAPB: view
genes like me logo Genes that share phenotypes with NAPB: view

Animal Models for NAPB Gene

MGI Knock Outs for NAPB:

miRNA for NAPB Gene

miRTarBase miRNAs that target NAPB

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NAPB Gene

Localization for NAPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPB Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPB Gene COMPARTMENTS Subcellular localization image for NAPB gene
Compartment Confidence
extracellular 5
vacuole 3

Gene Ontology (GO) - Cellular Components for NAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005774 vacuolar membrane IBA --
GO:0031201 SNARE complex IBA --
GO:0043209 myelin sheath --
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with NAPB: view

Pathways & Interactions for NAPB Gene

genes like me logo Genes that share pathways with NAPB: view

Gene Ontology (GO) - Biological Process for NAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0010807 regulation of synaptic vesicle priming --
GO:0035249 synaptic transmission, glutamatergic --
GO:0035494 SNARE complex disassembly IBA --
GO:0061025 membrane fusion IBA --
genes like me logo Genes that share ontologies with NAPB: view

No data available for SIGNOR curated interactions for NAPB Gene

Drugs & Compounds for NAPB Gene

No Compound Related Data Available

Transcripts for NAPB Gene

Unigene Clusters for NAPB Gene

N-ethylmaleimide-sensitive factor attachment protein, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NAPB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - -
SP14: -
SP15: - -
SP16:

ExUns: 13b · 13c · 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for NAPB Gene

GeneLoc Exon Structure for
NAPB
ECgene alternative splicing isoforms for
NAPB

Expression for NAPB Gene

mRNA expression in normal human tissues for NAPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NAPB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.9), Brain - Anterior cingulate cortex (BA24) (x6.4), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for NAPB Gene

This gene is overexpressed in Brain (25.0), Frontal cortex (14.7), Retina (8.6), and Spinal cord (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NAPB Gene



SOURCE GeneReport for Unigene cluster for NAPB Gene Hs.269471

genes like me logo Genes that share expression patterns with NAPB: view

Protein tissue co-expression partners for NAPB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NAPB Gene

Orthologs for NAPB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAPB 35
  • 89.15 (n)
  • 99.33 (a)
NAPB 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPB 35
  • 93.85 (n)
  • 99.66 (a)
NAPB 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napb 35
  • 91.16 (n)
  • 100 (a)
Napb 16
Napb 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAPB 35
  • 99.89 (n)
  • 100 (a)
NAPB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napb 35
  • 92.06 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia NAPB 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NAPB 35
  • 83 (n)
  • 96.96 (a)
NAPB 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NAPB 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia napb 35
  • 83.33 (n)
  • 95.95 (a)
Str.15567 35
zebrafish
(Danio rerio)
Actinopterygii zgc:158643 35
  • 78.76 (n)
  • 87.46 (a)
NAPB (2 of 2) 36
  • 88 (a)
OneToMany
napba 36
  • 80 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.936 35
fruit fly
(Drosophila melanogaster)
Insecta Snap 37
  • 63 (a)
Snap 36
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea D1014.3 37
  • 50 (a)
snap-1 36
  • 49 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC17 36
  • 35 (a)
OneToMany
SEC17 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2218 36
  • 59 (a)
OneToMany
Species with no ortholog for NAPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPB Gene

ENSEMBL:
Gene Tree for NAPB (if available)
TreeFam:
Gene Tree for NAPB (if available)

Paralogs for NAPB Gene

Paralogs for NAPB Gene

(1) SIMAP similar genes for NAPB Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NAPB: view

Variants for NAPB Gene

Sequence variations from dbSNP and Humsavar for NAPB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs8615 -- 23,374,786(-) GTGGC(A/G)TCACT utr-variant-3-prime, nc-transcript-variant
rs16435 -- 23,374,819(+) AAAAT(-/ACT)GCTTT cds-indel
rs743020 -- 23,421,088(-) CGCGC(C/G)CTCCA intron-variant
rs743021 -- 23,421,070(-) CACAG(A/G)CCCCC intron-variant
rs743022 -- 23,420,492(+) TCCCC(C/G)GCGGG intron-variant

Variation tolerance for NAPB Gene

Residual Variation Intolerance Score: 45.21% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPB Gene

HapMap Linkage Disequilibrium report
NAPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NAPB Gene

Disorders for NAPB Gene

MalaCards: The human disease database

(1) MalaCards diseases for NAPB Gene - From: OMIM

Disorder Aliases PubMed IDs
amyotrophy, hereditary neuralgic
  • brachial plexus neuritis
- elite association
Search NAPB in MalaCards View complete list of genes associated with diseases

Relevant External Links for NAPB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPB
genes like me logo Genes that share disorders with NAPB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NAPB Gene

Publications for NAPB Gene

  1. The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs. (PMID: 9697855) Osten P. … Ziff E.B. (Neuron 1998) 23 67
  2. SNAP family of NSF attachment proteins includes a brain-specific isoform. (PMID: 8455721) Whiteheart S.W. … Rothman J.E. (Nature 1993) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 67

Products for NAPB Gene

Sources for NAPB Gene

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