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Aliases for NAPA Gene

Aliases for NAPA Gene

  • NSF Attachment Protein Alpha 2 3 5
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha 2 3
  • Alpha Soluble NSF Attachment Protein 2 3
  • SNAPA 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha 4
  • Alpha SNAP 2
  • Alpha-SNAP 3
  • SNAP-Alpha 4

External Ids for NAPA Gene

Previous GeneCards Identifiers for NAPA Gene

  • GC19M048637
  • GC19M048381
  • GC19M052666
  • GC19M052682
  • GC19M052658
  • GC19M047990
  • GC19M044419

Summaries for NAPA Gene

Entrez Gene Summary for NAPA Gene

  • This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NAPA Gene

NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPB.

UniProtKB/Swiss-Prot for NAPA Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPA Gene

Genomics for NAPA Gene

Regulatory Elements for NAPA Gene

Promoters for NAPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NAPA on UCSC Golden Path with GeneCards custom track

Genomic Location for NAPA Gene

Chromosome:
19
Start:
47,487,634 bp from pter
End:
47,515,258 bp from pter
Size:
27,625 bases
Orientation:
Minus strand

Genomic View for NAPA Gene

Genes around NAPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPA Gene

Proteins for NAPA Gene

  • Protein details for NAPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54920-SNAA_HUMAN
    Recommended name:
    Alpha-soluble NSF attachment protein
    Protein Accession:
    P54920
    Secondary Accessions:
    • A8K879
    • Q96IK3
    • Q9BVJ3

    Protein attributes for NAPA Gene

    Size:
    295 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    • Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity).

neXtProt entry for NAPA Gene

Proteomics data for NAPA Gene at MOPED

Post-translational modifications for NAPA Gene

  • Ubiquitination at Lys 22 and Lys 227
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NAPA Gene

Domains & Families for NAPA Gene

Protein Domains for NAPA Gene

Suggested Antigen Peptide Sequences for NAPA Gene

Graphical View of Domain Structure for InterPro Entry

P54920

UniProtKB/Swiss-Prot:

SNAA_HUMAN :
  • Belongs to the SNAP family.
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPA: view

No data available for Gene Families for NAPA Gene

Function for NAPA Gene

Molecular function for NAPA Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
genes like me logo Genes that share phenotypes with NAPA: view

Animal Models for NAPA Gene

MGI Knock Outs for NAPA:

Animal Model Products

  • Taconic Biosciences Mouse Models for NAPA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NAPA Gene

Localization for NAPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPA Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPA Gene COMPARTMENTS Subcellular localization image for NAPA gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
vacuole 4
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NAPA: view

Pathways & Interactions for NAPA Gene

genes like me logo Genes that share pathways with NAPA: view

Pathways by source for NAPA Gene

Gene Ontology (GO) - Biological Process for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010807 regulation of synaptic vesicle priming IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0030182 neuron differentiation IEA --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with NAPA: view

No data available for SIGNOR curated interactions for NAPA Gene

Drugs & Compounds for NAPA Gene

(4) Drugs for NAPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for NAPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAPA: view

Transcripts for NAPA Gene

Unigene Clusters for NAPA Gene

N-ethylmaleimide-sensitive factor attachment protein, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - -
SP16: - -
SP17:
SP18:

ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -

Relevant External Links for NAPA Gene

GeneLoc Exon Structure for
NAPA
ECgene alternative splicing isoforms for
NAPA

Expression for NAPA Gene

mRNA expression in normal human tissues for NAPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPA Gene

This gene is overexpressed in Bone (10.1) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAPA Gene



SOURCE GeneReport for Unigene cluster for NAPA Gene Hs.730799

genes like me logo Genes that share expression patterns with NAPA: view

Protein tissue co-expression partners for NAPA Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPA Gene

Orthologs for NAPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NAPA 35
  • 92.09 (n)
  • 98.98 (a)
NAPA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPA 35
  • 92.54 (n)
  • 97.29 (a)
NAPA 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napa 35
  • 90.51 (n)
  • 98.31 (a)
Napa 16
Napa 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NAPA 35
  • 99.66 (n)
  • 100 (a)
NAPA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napa 35
  • 90.73 (n)
  • 98.31 (a)
oppossum
(Monodelphis domestica)
Mammalia NAPA 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia napa 35
  • 80 (n)
  • 90.85 (a)
Str.15791 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16759 35
zebrafish
(Danio rerio)
Actinopterygii napab 35
  • 75.82 (n)
  • 84.07 (a)
wufa26c04 35
napa 36
  • 84 (a)
OneToMany
NAPA (2 of 2) 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Snap 37
  • 61 (a)
Snap 35
  • 65.58 (n)
  • 62.32 (a)
Snap 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003192 35
  • 65.94 (n)
  • 67.39 (a)
worm
(Caenorhabditis elegans)
Secernentea D1014.3 37
  • 51 (a)
snap-1 35
  • 55.35 (n)
  • 52.35 (a)
snap-1 36
  • 50 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR155C 35
  • 49.76 (n)
  • 33.7 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05919g 35
  • 45.77 (n)
  • 34.06 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC17 35
  • 47.09 (n)
  • 36.06 (a)
SEC17 36
  • 35 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01674 35
  • 49.94 (n)
  • 37.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec17 35
  • 47.45 (n)
  • 37.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2218 36
  • 59 (a)
OneToMany
Species with no ortholog for NAPA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPA Gene

ENSEMBL:
Gene Tree for NAPA (if available)
TreeFam:
Gene Tree for NAPA (if available)

Paralogs for NAPA Gene

Paralogs for NAPA Gene

(1) SIMAP similar genes for NAPA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with NAPA: view

Variants for NAPA Gene

Sequence variations from dbSNP and Humsavar for NAPA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1075683 -- 47,505,659(+) ACCAG(C/T)GATCA intron-variant
rs698699 -- 47,508,291(-) CCCAG(C/T)TCCAG intron-variant
rs698700 -- 47,508,106(-) GCAGC(C/T)CCAGC intron-variant
rs698707 -- 47,515,603(-) AGTTC(A/C/G/T)AGTAC upstream-variant-2KB
rs2037735 -- 47,509,212(-) TTTGT(A/G)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NAPA Gene

Variant ID Type Subtype PubMed ID
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912202 CNV Loss 21882294
esv2718664 CNV Deletion 23290073
esv2131971 CNV Deletion 18987734
esv2718665 CNV Deletion 23290073
nsv138407 CNV Loss 16902084

Variation tolerance for NAPA Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPA Gene

HapMap Linkage Disequilibrium report
NAPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPA Gene

Disorders for NAPA Gene

Relevant External Links for NAPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPA

No disorders were found for NAPA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPA Gene

Publications for NAPA Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons P.P. … Whiteheart S.W. (Blood 1997) 2 3 4 67
  2. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PMID: 15542541) Tomes C.N. … Mayorga L.S. (Mol. Hum. Reprod. 2005) 3 23
  3. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PMID: 15980433) Andreeva A.V. … Voyno-Yasenetskaya T. (J. Biol. Chem. 2005) 3 23
  4. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 3 23
  5. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PMID: 9507000) Tang B.L. … Hong W. (J. Biol. Chem. 1998) 3 23

Products for NAPA Gene

Sources for NAPA Gene

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