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NAPA Gene

protein-coding GIFtS: 56

GC19M052658

N-ethylmaleimide-sensitive factor attachment protein, alpha
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
S ^⁵
SNAP-alpha ^³
SNAPA ^², ³
alpha-SNAP ^²

Descriptions
N-ethylmaleimide-sensitive factor attachment protein alpha ^³
N-ethylmaleimide-sensitive factor attachment protein, alpha ^²

External Ids
HGNC: 7641¹
Entrez Gene: 8775²
UniProtKB: P54920³
Ensembl: ENSG00000105402⁷

Search outside databases for aliases for NAPA gene

Previous GC identifers: GC19M048637 GC19M048381 GC19M052666 GC19M052682

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NAPA:

The 'SNARE hypothesis' is a model explaining the process of docking and fusion of

vesicles to their target membranes. According to this model, membrane proteins from the vesicle

(v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle

targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other,

they form a complex that recruits the general elements of the fusion apparatus, namely NSF

(N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of

membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide

range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted

295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences

of yeast, Drosophila, and squid alpha-SNAP, respectively. Platelets contain some of the same

proteins, including NSF, p115/TAP, alpha-SNAP, gamma-SNAP, and the t-SNAREs syntaxin-2 and

syntaxin-4, that are used in many vesicular transport processes in other cell types. Platelet

exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as

neurons, although the proteins used by the platelet and their modes of regulation may be quite

different. [provided by RefSeq]

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920

Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi

apparatus

Gene Wiki entry for NAPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NAPA gene

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.33

NAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M052658: (about GC identifiers)

Start:	52,682,703 bp from pter
End:	52,710,309 bp from pter
Size:	27,607 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920 (See protein sequence)

Recommended Name: Alpha-soluble NSF attachment protein

Size: 295 amino acids; 33233 Da

Subunit: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to

the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a

SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha

Subcellular location: Membrane; Peripheral membrane protein

Secondary accessions: Q96IK3 Q9BVJ3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003818.2

ENSEMBL proteins:

ENSP00000263354

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Alpha SNAP, alpha+beta SNAP)
	Human Recombinant Proteins from Abnova (NAPA)

OriGene Purified Recombinant Human Protein: NAPA

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--

About this table

Antibodies for NAPA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for NAPA
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Alpha SNAP, alpha+beta SNAP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for NAPA

Assays for NAPA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P54920

ProtoNet protein and cluster: P54920

1 Blocks protein family: IPB000744 NSF attachment protein signature

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920

Similarity: Belongs to the SNAP family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAPA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003827

Applied Biosystems Silencer® siRNAs for NAPA

Sigma-Aldrich siRNA for NAPA

Sigma-Aldrich shRNA for NAPA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NAPA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003827
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003827
untagged cDNA clone in CMV expression vector: NM_003827

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003827

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920

Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi

apparatus

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Napa):

behavior/neurological	craniofacial	hearing/vestibular/ear	lethality-prenatal/perinatal	life span-post-weaning/aging
nervous system	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16189514
GO:0019905	syntaxin binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for NAPA (Your Favorite Gene powered by Ingenuity)

Huntington's Disease Signaling

GeneDecks NAPA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NAPA

5/13 Interacting proteins for NAPA (P54920¹ ENSP00000263354³) via UniProtKB, MINT, and/or STRING (see all 13 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STX4	Q12846¹, ENSP00000317714³	EBI-749652, EBI-744942 STRING (score=.72)
SNAP23	O00161¹	EBI-749652, EBI-745000
STX6	ENSP00000258301³	STRING (score=.95)
NSF	ENSP00000225282³	STRING (score=.907)
STX7	ENSP00000309600³	STRING (score=.88)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006886	intracellular protein transport	IEA	--
GO:0006891	intra-Golgi vesicle-mediated transport	TAS	8455721
GO:0006944	membrane fusion	TAS	8455721
GO:0007420	brain development	IEA	--
GO:0016192	vesicle-mediated transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for NAPA
5 Novoseek chemical compound relationships for NAPA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mgatp	50.49	2	9362506 (1)
atp	35.04	9	9325254 (2), 7957884 (1), 8744944 (1), 8702750 (1) (see all 5)
catecholamine	11.67	2	7835334 (1), 10662817 (1)
lipid	0.00	7	9230135 (3), 17922004 (2), 10716927 (1)
calcium	0.00	6	7835334 (1), 19208619 (1), 8876242 (1), 7501022 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NAPA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003827

Sigma-Aldrich siRNA for NAPA

Sigma-Aldrich shRNA for NAPA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003827

REFSEQ mRNAs for NAPA gene:

NM_003827.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003827

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003827
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003827
                                 untagged cDNA clone in CMV expression vector: NM_003827

Additional cDNA sequence:

AK098401.1 AK292244.1 AK308633.1 AK310114.1 AK310185.1 AY927522.1 AY927608.1 AY927609.1

AY927610.1 BC001165.1 BC007432.2 BC028234.1 BC091511.1 BT019568.1 CR590241.1 CR590968.1

CR591989.1 CR593591.1 CR595321.1 CR595466.1 CR595865.1 CR596698.1 CR597857.1 CR600985.1

CR603138.1 CR603798.1 CR604334.1 CR605446.1 CR605749.1 CR606227.1 CR607595.1 CR612768.1

CR613630.1 CR613768.1 CR615344.1 CR617474.1 CR620868.1 CR622385.1 CR622644.1 CR624444.1

CR624846.1 U39412.1

24/37 DOTS entries (see all 37 ):

DT.219085 DT.100880773 DT.95235725 DT.100880761 DT.95231931 DT.95253523 DT.100760885 DT.102834206

DT.40316388 DT.435399 DT.92455399 DT.121497234 DT.121497297 DT.100809518 DT.121497264 DT.40266091

DT.95173652 DT.95173659 DT.95173673 DT.100880760 DT.101984713 DT.121497214 DT.121497215 DT.92455388

24/725 AceView cDNA sequences (see all 725 ):

AI751472 BM547283 AI076126 CR605446 BU163298 BC001165 BF965926 BE894926

BM664442 BP370365 BE780183 BE264255 BQ549677 CF265000 AI097319 BG474369

BU069484 BQ128368 AA632239 BU787527 BU527654 AJ713063 BM512442 BQ668660

highest scoring ESTs for NAPA:

U39412 AA171407 AA459161 AA879443 AA928239 AK098401 AL040292 AL536478 AL553335 AU076757

Unigene Cluster for NAPA:

N-ethylmaleimide-sensitive factor attachment protein, alpha

Hs.719083 [show with all ESTs]

Unigene Representative Sequence: NM_003827

GeneLoc Exon Structure

5/18 Alternative Splicing Database (ASD) splice patterns (SP) for NAPA (see all 18 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	·	11c	·	11d	·	11e	^	12	^	13a	·
SP1:											-						-				-		-		-				-				-				-						-		-		-
SP2:											-		-				-				-		-		-				-				-				-						-		-		-
SP3:											-		-				-				-		-		-				-				-				-		-		-		-		-		-				-
SP4:											-		-				-		-		-		-		-				-				-				-
SP5:											-		-				-				-		-		-				-				-

ExUns:	13b	^	14	^	15a	·	15b	·	15c	·	15d	^	16
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NAPA

1 Ensembl transcript including schematic representation:

ENST00000263354

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

NAPA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NAPA

¹ / ² / ³

5 probe-sets matching NAPA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36977_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U39412	1.00	1.00	1.00	1
208751_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC001165	0.80	1.00	0.91	1
206491_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003827	0.60	1.00	0.82	1
208751_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206491_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.719083
Expression variation in blood from EXPOLDB for NAPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NAPA gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NAPA¹	--	N-ethylmaleimide-sensitive factor attachment protein, more	92.54(n) 97.29(a)	612960 XM_847061.1 XP_852154.1
chimpanzee (Pan troglodytes)	NAPA¹	--	N-ethylmaleimide-sensitive factor attachment protein, more	99.55(n) 100(a)	456168 XM_512785.2 XP_512785.2
rat (Rattus norvegicus)	Napa¹	--	N-ethylmaleimide-sensitive factor attachment protein, more	90.73(n) 98.31(a)	140673 NM_080585.1 NP_542152.1
mouse (Mus musculus)	Napa^{1, 5}	7 (15.20 cM)⁵	N-ethylmaleimide sensitive fusion protein attachment more^{1, 5}	90.51(n)¹ 98.31(a)¹	108124¹ NM_025898.2¹ NP_080174.1¹ AI838341⁵ AK004826⁵ (see all 20)
zebrafish (Danio rerio)	wufa26c04²	--	wufa26c04	76.66(n)	327082 AY398385.1

About this table Species with no ortholog for NAPA

ENSEMBL Gene Tree for NAPA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NAPA gene

NAPB²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/179 NCBI SNPs in NAPA are shown (see all 179 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs698707^1,2	C,F,H	52710672(-)	`AGTTCC/TAGTAC`	1	--	ng3¹		9		EU EA WA NA MN	892
	rs10853789^1,2	A,C,F	52683263(-)	`TCCCAT/CCTGGG`	1	--	ut3¹		1		MN	184
--	rs830136^1,2	A,C	52712229(-)	`gagacA/Ggagtc`	1	--	ng3¹		0	--	--	--	--
--	rs830149^1,2	C,F	52683253(-)	`GGAGTC/GCCGCG`	1	--	ut3¹ ese³		1		MN	184
--	rs10426242^1,2	C	52712215(+)	`ggggaC/Taagag`	1	--	ng3¹		0	--	--	--	--
--	rs10425345^1,2	C	52711813(+)	`ttaacA/Ctcaac`	1	--	ng3¹		0	--	--	--	--
--	rs12462794^1,2	C	52711186(+)	`tcaagA/Tcccgc`	1	--	ng3¹		0	--	--	--	--
--	rs10426196^1,2	C	52712148(+)	`aggatA/Cacttg`	1	--	ng3¹		0	--	--	--	--
--	rs10221539^1,2	C	52711944(+)	`ctcaaA/Cactgt`	1	--	ng3¹		0	--	--	--	--
	rs830146^1,2	A,C,F,H,O	52698909(-)	`TAGCGT/CGCCTG`	1	--	int¹		8		EA NA EU WA	1862

About this table

HapMap Linkage Disequilibrium images for NAPA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603215

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/84 PubMed articles for NAPA gene (see all 84 ):

Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PubMed id 9269766)^{2, 3, 4} Lemons P.P.... Whiteheart S.W. (1997)
Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)^{3, 4} Hirose H....Tagaya M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. (PubMed id 9362506)^{1, 3} Barnard R.J....Burgoyne R.D. (1997)
G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PubMed id 15980433)^{1, 3} Andreeva A.V....Voyno-Yasenetskaya T. (2005)
The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. (PubMed id 7622514)^{1, 3} Hanson P.I....Jahn R. (1995)
N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PubMed id 9325254)^{1, 3} Subramaniam V.N....Hong W. (1997)
alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PubMed id 15542541)^{1, 3} Tomes C.N....Mayorga L.S. (2005)
Syntaxin 12, a member of the syntaxin family localized to the endosome. (PubMed id 9507000)^{1, 3} Tang B.L....Hong W. (1998)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8775	HGNC: 7641	AceView: NAPA	Ensembl:ENSG00000105402	euGenes: HUgn8775
ECgene: NAPA	H-InvDB: NAPA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for NAPA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for NAPA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NAPA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NAPA		Antibodies for NAPA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NAPA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NAPA)
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Alpha SNAP, alpha+beta SNAP)
	Antibodies (Alpha SNAP, alpha+beta SNAP)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for NAPA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for NAPA

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

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NAPA Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for NAPA

Summaries
for NAPA

Genomic Location
for NAPA

Proteins
for NAPA

Protein Domains/
Families
for NAPA

Gene Function
for NAPA

Pathways & Interactions
for NAPA

Drugs & Compounds
for NAPA

Transcripts
for NAPA

Expression
for NAPA

Orthologs
for NAPA

Paralogs
for NAPA

SNPs/Variants
for NAPA

Disorders & Mutations
for NAPA

Medical News
for NAPA

Publications
for NAPA

Search for NAPA

Genome Databases showing NAPA

Other Databases showing NAPA

Specialized Databases showing NAPA

Licensable Technologies
for NAPA

Services
for NAPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NAPA Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor NAPA

Summariesfor NAPA

Genomic Locationfor NAPA

Proteinsfor NAPA

Protein Domains/Familiesfor NAPA

Gene Functionfor NAPA

Pathways & Interactionsfor NAPA

Drugs & Compoundsfor NAPA

Transcriptsfor NAPA

Expression for NAPA

Orthologsfor NAPA

Paralogsfor NAPA

SNPs/Variantsfor NAPA

Disorders & Mutationsfor NAPA

Medical Newsfor NAPA

Publicationsfor NAPA

Search for NAPA

Genome Databases showing NAPA

Other Databases showing NAPA

Specialized Databases showing NAPA

Licensable Technologiesfor NAPA

Servicesfor NAPA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NAPA

Summaries
for NAPA

Genomic Location
for NAPA

Proteins
for NAPA

Protein Domains/
Families
for NAPA

Gene Function
for NAPA

Pathways & Interactions
for NAPA

Drugs & Compounds
for NAPA

Transcripts
for NAPA

Expression
for NAPA

Orthologs
for NAPA

Paralogs
for NAPA

SNPs/Variants
for NAPA

Disorders & Mutations
for NAPA

Medical News
for NAPA

Publications
for NAPA

Licensable Technologies
for NAPA

Services
for NAPA