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Aliases for NAPA Gene

Aliases for NAPA Gene

  • NSF Attachment Protein Alpha 2 3 5
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha 2 3
  • SNAPA 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha 4
  • Alpha Soluble NSF Attachment Protein 2
  • Alpha-Soluble NSF Attachment Protein 3
  • Alpha SNAP 2
  • Alpha-SNAP 3
  • SNAP-Alpha 4

External Ids for NAPA Gene

Previous GeneCards Identifiers for NAPA Gene

  • GC19M048637
  • GC19M048381
  • GC19M052666
  • GC19M052682
  • GC19M052658
  • GC19M047990
  • GC19M044419

Summaries for NAPA Gene

Entrez Gene Summary for NAPA Gene

  • This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NAPA Gene

NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include syntaxin binding and soluble NSF attachment protein activity. An important paralog of this gene is NAPB.

UniProtKB/Swiss-Prot for NAPA Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Wiki entry for NAPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPA Gene

Genomics for NAPA Gene

Regulatory Elements for NAPA Gene

Enhancers for NAPA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F047598 1.1 FANTOM5 Ensembl ENCODE 13 -85.0 -84962 4.2 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 FOS ZNF541 NAPA GLTSCR2 SNORD23 BBC3 GLTSCR1 INAFM1 GC19P047605 GC19P047592
GH19F047312 0.9 FANTOM5 ENCODE 13 +201.7 201714 1.7 HDGF ATF1 ARNT CREB3L1 MLX ARID4B DMAP1 ZNF48 ZNF121 GTF3C2 DHX34 C5AR2 ZC3H4 CCDC9 GLTSCR1 C5AR1 NAPA GLTSCR2-AS1 BBC3
GH19F047329 1.5 FANTOM5 Ensembl ENCODE 12.2 +184.2 184213 3.5 BCOR GTF2F1 TBP CBX3 TAF1 ZMYM3 MAX RAD21 TEAD3 POLR3A NAPA C5AR1 C5AR2 ZC3H4 DHX34 CCDC9 GLTSCR1 GLTSCR2
GH19F047595 0.9 Ensembl ENCODE 11.6 -80.7 -80672 1.1 ZNF316 EMSY NAPA ZNF541 GLTSCR2 SNORD23 GLTSCR1 GC19P047592 GC19P047605
GH19F047775 1 ENCODE 10 -263.5 -263468 5.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SELENOW ZC3H4 GRWD1 CCDC9 KDELR1 GLTSCR2-AS1 GLTSCR1 SLC1A5 GLTSCR2 SNORD23
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NAPA on UCSC Golden Path with GeneCards custom track

Promoters for NAPA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044974 358 2601 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 ZNF207

Genomic Location for NAPA Gene

Chromosome:
19
Start:
47,487,634 bp from pter
End:
47,515,258 bp from pter
Size:
27,625 bases
Orientation:
Minus strand

Genomic View for NAPA Gene

Genes around NAPA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NAPA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NAPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPA Gene

Proteins for NAPA Gene

  • Protein details for NAPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54920-SNAA_HUMAN
    Recommended name:
    Alpha-soluble NSF attachment protein
    Protein Accession:
    P54920
    Secondary Accessions:
    • A8K879
    • Q96IK3
    • Q9BVJ3

    Protein attributes for NAPA Gene

    Size:
    295 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    • Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity).

neXtProt entry for NAPA Gene

Post-translational modifications for NAPA Gene

  • Ubiquitination at Lys 22 and Lys 227
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NAPA Gene

Domains & Families for NAPA Gene

Protein Domains for NAPA Gene

Suggested Antigen Peptide Sequences for NAPA Gene

Graphical View of Domain Structure for InterPro Entry

P54920

UniProtKB/Swiss-Prot:

SNAA_HUMAN :
  • Belongs to the SNAP family.
Family:
  • Belongs to the SNAP family.
genes like me logo Genes that share domains with NAPA: view

No data available for Gene Families for NAPA Gene

Function for NAPA Gene

Molecular function for NAPA Gene

UniProtKB/Swiss-Prot Function:
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IEA,ISS --
GO:0005483 soluble NSF attachment protein activity IBA --
GO:0005515 protein binding IPI 15029241
GO:0019905 syntaxin binding IBA --
GO:0032403 protein complex binding ISS --
genes like me logo Genes that share ontologies with NAPA: view
genes like me logo Genes that share phenotypes with NAPA: view

Animal Models for NAPA Gene

MGI Knock Outs for NAPA:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NAPA Gene

Localization for NAPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPA Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPA Gene COMPARTMENTS Subcellular localization image for NAPA gene
Compartment Confidence
cytosol 5
extracellular 5
golgi apparatus 5
vacuole 4
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IEA --
GO:0005774 vacuolar membrane IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with NAPA: view

Pathways & Interactions for NAPA Gene

genes like me logo Genes that share pathways with NAPA: view

Gene Ontology (GO) - Biological Process for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA,IBA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8455721
genes like me logo Genes that share ontologies with NAPA: view

No data available for SIGNOR curated interactions for NAPA Gene

Drugs & Compounds for NAPA Gene

(4) Drugs for NAPA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for NAPA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NAPA: view

Transcripts for NAPA Gene

Unigene Clusters for NAPA Gene

N-ethylmaleimide-sensitive factor attachment protein, alpha:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NAPA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - -
SP16: - -
SP17:
SP18:

ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -

Relevant External Links for NAPA Gene

GeneLoc Exon Structure for
NAPA
ECgene alternative splicing isoforms for
NAPA

Expression for NAPA Gene

mRNA expression in normal human tissues for NAPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NAPA Gene

This gene is overexpressed in Bone (10.1) and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NAPA Gene



Protein tissue co-expression partners for NAPA Gene

NURSA nuclear receptor signaling pathways regulating expression of NAPA Gene:

NAPA

SOURCE GeneReport for Unigene cluster for NAPA Gene:

Hs.730799
genes like me logo Genes that share expression patterns with NAPA: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NAPA Gene

Orthologs for NAPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPA 34 35
  • 99.66 (n)
oppossum
(Monodelphis domestica)
Mammalia NAPA 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPA 34 35
  • 92.54 (n)
cow
(Bos Taurus)
Mammalia NAPA 34 35
  • 92.09 (n)
rat
(Rattus norvegicus)
Mammalia Napa 34
  • 90.73 (n)
mouse
(Mus musculus)
Mammalia Napa 34 16 35
  • 90.51 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 90 (a)
OneToMany
-- 35
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia napa 34
  • 80 (n)
Str.15791 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16759 34
zebrafish
(Danio rerio)
Actinopterygii napa 35
  • 84 (a)
OneToMany
napab 34
  • 75.82 (n)
NAPA (2 of 2) 35
  • 75 (a)
OneToMany
wufa26c04 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003192 34
  • 65.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta Snap 36 34 35
  • 65.58 (n)
worm
(Caenorhabditis elegans)
Secernentea snap-1 34 35
  • 55.35 (n)
D1014.3 36
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR155C 34
  • 49.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC17 34 35
  • 47.09 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05919g 34
  • 45.77 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2218 35
  • 59 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01674 34
  • 49.94 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec17 34
  • 47.45 (n)
Species where no ortholog for NAPA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPA Gene

ENSEMBL:
Gene Tree for NAPA (if available)
TreeFam:
Gene Tree for NAPA (if available)

Paralogs for NAPA Gene

Paralogs for NAPA Gene

(1) SIMAP similar genes for NAPA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with NAPA: view

Variants for NAPA Gene

Sequence variations from dbSNP and Humsavar for NAPA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10221539 -- 47,516,875(+) ctcaa(A/C)actgt upstream-variant-2KB
rs10408883 -- 47,489,762(+) AATTT(C/T)TGCAA intron-variant, splice-acceptor-variant
rs10418003 -- 47,500,033(+) CTCTT(C/T)GGGAG intron-variant
rs10419267 -- 47,494,737(+) tctca(A/C)aaaaa intron-variant
rs10425345 -- 47,516,744(+) ttaac(A/C)tcaac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAPA Gene

Variant ID Type Subtype PubMed ID
esv2131971 CNV deletion 18987734
esv2718664 CNV deletion 23290073
esv2718665 CNV deletion 23290073
esv2758765 CNV loss 17122850
esv3346749 CNV duplication 20981092
esv3556493 CNV deletion 23714750
nsv1056887 CNV gain 25217958
nsv1116643 CNV deletion 24896259
nsv138407 CNV deletion 16902084
nsv428366 CNV loss 18775914
nsv579888 CNV gain 21841781
nsv953591 CNV deletion 24416366

Variation tolerance for NAPA Gene

Residual Variation Intolerance Score: 25.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NAPA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NAPA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NAPA Gene

Disorders for NAPA Gene

Relevant External Links for NAPA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NAPA

No disorders were found for NAPA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NAPA Gene

Publications for NAPA Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons P.P. … Whiteheart S.W. (Blood 1997) 2 3 4 64
  2. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PMID: 15542541) Tomes C.N. … Mayorga L.S. (Mol. Hum. Reprod. 2005) 3 22 64
  3. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PMID: 15980433) Andreeva A.V. … Voyno-Yasenetskaya T. (J. Biol. Chem. 2005) 3 22 64
  4. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PMID: 15029241) Hirose H. … Tagaya M. (EMBO J. 2004) 3 4 64
  5. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 3 22 64

Products for NAPA Gene

Sources for NAPA Gene

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