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Aliases for NAPA Gene

Aliases for NAPA Gene

  • N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha 2 3
  • SNAPA 3 4
  • N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha 4
  • Alpha-Soluble NSF Attachment Protein 3
  • Alpha SNAP 2
  • Alpha-SNAP 3
  • SNAP-Alpha 4
  • S 6

External Ids for NAPA Gene

Summaries for NAPA Gene

Entrez Gene Summary for NAPA Gene

  • This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jun 2011]

GeneCards Summary for NAPA Gene

NAPA (N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is NAPB.

UniProtKB/Swiss-Prot for NAPA Gene

  • Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Wiki entry for NAPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NAPA Gene

Genomics for NAPA Gene

Genomic Location for NAPA Gene

Start:
47,487,634 bp from pter
End:
47,515,258 bp from pter
Size:
27,625 bases
Orientation:
Minus strand

Genomic View for NAPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NAPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NAPA Gene

Regulatory Elements for NAPA Gene

Proteins for NAPA Gene

  • Protein details for NAPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54920-SNAA_HUMAN
    Recommended name:
    Alpha-soluble NSF attachment protein
    Protein Accession:
    P54920
    Secondary Accessions:
    • A8K879
    • Q96IK3
    • Q9BVJ3

    Protein attributes for NAPA Gene

    Size:
    295 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    • Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity).

neXtProt entry for NAPA Gene

Proteomics data for NAPA Gene at MOPED

Post-translational modifications for NAPA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys22, Lys153, and Lys227

Other Protein References for NAPA Gene

No data available for DME Specific Peptides for NAPA Gene

Domains for NAPA Gene

Protein Domains for NAPA Gene

UniProtKB/Swiss-Prot:

SNAA_HUMAN
Family:
  • Belongs to the SNAP family.:
    • P54920
genes like me logo Genes that share domains with NAPA: view

No data available for Gene Families for NAPA Gene

Function for NAPA Gene

Molecular function for NAPA Gene

UniProtKB/Swiss-Prot Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Ontology (GO) - Molecular Function for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding --
GO:0005483 soluble NSF attachment protein activity IBA --
GO:0005515 protein binding IPI 15029241
GO:0019905 syntaxin binding IBA --
genes like me logo Genes that share ontologies with NAPA: view
genes like me logo Genes that share phenotypes with NAPA: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NAPA Gene

Localization for NAPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for NAPA Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NAPA Gene COMPARTMENTS Subcellular localization image for NAPA gene
Compartment Confidence
cytosol 4
golgi apparatus 2
nucleus 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005774 vacuolar membrane IBA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0031201 SNARE complex IBA --
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA --
genes like me logo Genes that share ontologies with NAPA: view

Pathways for NAPA Gene

genes like me logo Genes that share pathways with NAPA: view

Pathways by source for NAPA Gene

Gene Ontology (GO) - Biological Process for NAPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006891 intra-Golgi vesicle-mediated transport TAS 8455721
GO:0006892 post-Golgi vesicle-mediated transport TAS --
GO:0007420 brain development IEA --
GO:0010807 regulation of synaptic vesicle priming IEA --
genes like me logo Genes that share ontologies with NAPA: view

Compounds for NAPA Gene

(7) Novoseek inferred chemical compound relationships for NAPA Gene

Compound -log(P) Hits PubMed IDs
n-ethylmaleimide 66.2 5
mgatp 50 1
atp 36.9 6
catecholamine 10.9 2
cysteine 5.87 2
genes like me logo Genes that share compounds with NAPA: view

Transcripts for NAPA Gene

Unigene Clusters for NAPA Gene

N-ethylmaleimide-sensitive factor attachment protein, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NAPA Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: - - - - - - - - - - -
SP14: - - - -
SP15: - - - - - - - - - -
SP16: - -
SP17:
SP18:

ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18: - -

Relevant External Links for NAPA Gene

GeneLoc Exon Structure for
NAPA
ECgene alternative splicing isoforms for
NAPA

Expression for NAPA Gene

mRNA expression in normal human tissues for NAPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NAPA Gene

SOURCE GeneReport for Unigene cluster for NAPA Gene Hs.730799

genes like me logo Genes that share expressions with NAPA: view

Orthologs for NAPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NAPA 36
  • 99.66 (n)
  • 100 (a)
NAPA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NAPA 36
  • 92.09 (n)
  • 98.98 (a)
NAPA 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NAPA 36
  • 92.54 (n)
  • 97.29 (a)
NAPA 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Napa 36
  • 90.51 (n)
  • 98.31 (a)
Napa 16
Napa 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NAPA 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Napa 36
  • 90.73 (n)
  • 98.31 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 89 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.16759 36
tropical clawed frog
(Silurana tropicalis)
Amphibia napa 36
  • 80 (n)
  • 90.85 (a)
Str.15791 36
zebrafish
(Danio rerio)
Actinopterygii napa 37
  • 84 (a)
OneToMany
NAPA (2 of 2) 37
  • 75 (a)
OneToMany
napab 36
  • 75.82 (n)
  • 84.07 (a)
wufa26c04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003192 36
  • 65.94 (n)
  • 67.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Snap 36
  • 65.58 (n)
  • 62.32 (a)
Snap 37
  • 61 (a)
OneToMany
Snap 38
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea snap-1 36
  • 55.35 (n)
  • 52.35 (a)
snap-1 37
  • 50 (a)
OneToMany
D1014.3 38
  • 51 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR155C 36
  • 49.76 (n)
  • 33.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC17 36
  • 47.09 (n)
  • 36.06 (a)
SEC17 37
  • 35 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05919g 36
  • 45.77 (n)
  • 34.06 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01674 36
  • 49.94 (n)
  • 37.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sec17 36
  • 47.45 (n)
  • 37.96 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2218 37
  • 59 (a)
OneToMany
Species with no ortholog for NAPA:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NAPA Gene

ENSEMBL:
Gene Tree for NAPA (if available)
TreeFam:
Gene Tree for NAPA (if available)

Paralogs for NAPA Gene

Paralogs for NAPA Gene

Selected SIMAP similar genes for NAPA Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with NAPA: view

Variants for NAPA Gene

Sequence variations from dbSNP and Humsavar for NAPA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs698699 -- 47,508,291(-) CCCAG(C/T)TCCAG intron-variant
rs698700 -- 47,508,106(-) GCAGC(C/T)CCAGC intron-variant
rs698707 -- 47,515,603(-) AGTTC(A/C/G/T)AGTAC upstream-variant-2KB
rs830136 -- 47,517,160(-) gagac(A/G)gagtc upstream-variant-2KB
rs830137 -- 47,514,077(-) GAGGC(C/G)GGGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NAPA Gene

Variant ID Type Subtype PubMed ID
dgv1107e1 CNV Complex 17122850
nsv428366 CNV Loss 18775914
nsv912202 CNV Loss 21882294
esv2718664 CNV Deletion 23290073
esv2131971 CNV Deletion 18987734
esv2718665 CNV Deletion 23290073
nsv138407 CNV Loss 16902084

Relevant External Links for NAPA Gene

HapMap Linkage Disequilibrium report
NAPA

Disorders for NAPA Gene

(1) University of Copenhagen DISEASES for NAPA Gene

genes like me logo Genes that share disorders with NAPA: view

No data available for UniProtKB/Swiss-Prot for NAPA Gene

Publications for NAPA Gene

  1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PMID: 9269766) Lemons P.P. … Whiteheart S.W. (Blood 1997) 2 3 4
  2. N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PMID: 9325254) Subramaniam V.N. … Hong W. (J. Biol. Chem. 1997) 3 23
  3. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PMID: 15272311) Nakajima K. … Tagaya M. (EMBO J. 2004) 3 23
  4. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PMID: 15542541) Tomes C.N. … Mayorga L.S. (Mol. Hum. Reprod. 2005) 3 23
  5. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PMID: 15980433) Andreeva A.V. … Voyno-Yasenetskaya T. (J. Biol. Chem. 2005) 3 23

Products for NAPA Gene

Sources for NAPA Gene

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