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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAPA Gene

protein-coding   GIFtS: 60
GCID: GC19M047990

N-ethylmaleimide-sensitive factor attachment protein, alpha
 Explore 9 diseases affiliated with
NAPA via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NAPA    

Aliases
for NAPA gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha1 2     SNAP-Alpha1
SNAPA2 3     N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha3
Alpha-SNAP1     S5
Alpha-Soluble NSF Attachment Protein2     

External Ids:    HGNC: 76411   Entrez Gene: 87752   Ensembl: ENSG000001054027   OMIM: 6032155   UniProtKB: P549203   
ORGUL members:         
NONCODE:n410995 n410994    

Export aliases for NAPA gene to outside databases

Previous GC identifers: GC19M048637 GC19M048381 GC19M052666 GC19M052682 GC19M052658 GC19M044419


Summaries
for NAPA gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NAPA:
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in
the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded protein
plays a role in the completion of membrane fusion by mediating the interaction of N-ethylmaleimide-sensitive factor
(NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE) complex, and stimulating the ATPase
activity of NSF. Alternatively spliced transcript variants have been observed for this gene. (provided by RefSeq, Jun
2011)

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Wiki entry for NAPA


Genomic Views
for NAPA gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAPA gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NAPA promoter sequence
   Search SABiosciences Chromatin IP Primers for NAPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

NAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047990:  view genomic region     (about GC identifiers)

Start:
 47,990,891 bp from pter      End:
 48,018,497 bp from pter
Size:
 27,607 bases      Orientation:
 minus strand
ORGUL member locations:
Legend (see complete legend)

  • n410994
  • n410995
47990890 48004703 48018515 chr19

Proteins
for NAPA gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920 (See protein sequence)
Recommended Name: Alpha-soluble NSF attachment protein  
Size: 295 amino acids; 33233 Da
Subunit: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization
of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that contains at least
ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By similarity)
Subcellular location: Membrane; Peripheral membrane protein
Secondary accessions: A8K879 Q96IK3 Q9BVJ3

Explore the universe of human proteins at neXtProt for NAPA: NX_P54920

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54920

    • NAPA Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003818.2  
    ENSEMBL proteins: 
     ENSP00000263354  
    Reactome Protein details: P54920
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: NAPA
    OriGene Protein Over-expression Lysate: NAPA
    OriGene Custom Protein Services for NAPA 
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    Novus Biologicals NAPA Proteins
    Novus Biologicals NAPA Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NAPA
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA--


    NAPA for ontologies           About GeneDecksing



    NAPA Antibody Products: 
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    ThermoFisher Antibody for NAPA

    Assay Products for NAPA: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for NAPA gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NAPA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000744 NSF_attach
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry P54920

    ProtoNet protein and cluster: P54920

    1 Blocks protein family: IPB000744 NSF attachment protein signature

    UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
    Similarity: Belongs to the SNAP family


    Function
    for NAPA gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
    Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NAPA (see all 9):
    hsa-miR-4324 hsa-miR-1301 hsa-miR-548t hsa-miR-649 hsa-miR-1184 hsa-miR-1207-3p hsa-miR-628-5p hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NAPA 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAPA (see all 7)
    OriGene shRNA RFP: NAPA
    OriGene siRNA: NAPA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPA

    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for NAPA

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI16189514
    GO:0019905syntaxin binding IEA--


    NAPA for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NAPA:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty 

    Animal Models:
         6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Napa):
     behavior/neurological  craniofacial  hearing/vestibular/ear  mortality/aging  nervous system 
     skeleton 

    NAPA for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NAPA gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin derived vesicle budding
    		trans-Golgi Network Vesicle Budding1.00
    		Golgi Associated Vesicle Biogenesis0.89
    		Clathrin derived vesicle budding1.00
    2Membrane Trafficking
    		Membrane Trafficking1.00
    3Synaptic Vesicle Pathway
    		Synaptic Vesicle Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for NAPA 
        Synaptic Vesicle Pathway

    4        Reactome Pathways for NAPA
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding



    NAPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for NAPA (P549201, 2, 3 ENSP000002633544) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX4Q128461, 2, 3, ENSP000003177144EBI-749652,EBI-744942 MINT-68367 I2D: score=6 STRING: ENSP00000317714
    NSFP464592, 3, ENSP000003812934MINT-8217389 I2D: score=8 STRING: ENSP00000381293
    RTN4Q9NQC32, 3, ENSP000003378384MINT-67570 I2D: score=5 STRING: ENSP00000337838
    STX5Q131902, 3, ENSP000002941794MINT-67752 I2D: score=5 STRING: ENSP00000294179
    SNAP23O001611, 3, ENSP000002496474EBI-749652,EBI-745000 I2D: score=4 STRING: ENSP00000249647
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006891intra-Golgi vesicle-mediated transport TAS8455721
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0006944cellular membrane fusion TAS8455721
    GO:0007420brain development IEA--


    NAPA for ontologies           About GeneDecksing



    Drugs & Compounds
    for NAPA gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAPA
    7 Novoseek chemical compound relationships for NAPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 66.2 5 11279210 (1), 7835334 (1), 10716927 (1), 10601471 (1) (see all 5)
    mgatp 50 2 9362506 (1)
    atp 36.9 9 9325254 (2), 7957884 (1), 8744944 (1), 8702750 (1) (see all 5)
    catecholamine 10.9 2 7835334 (1), 10662817 (1)
    cysteine 5.87 3 10662817 (1), 11604405 (1)
    lipid 0 7 9230135 (3), 17922004 (2), 10716927 (1)
    calcium 0 6 7835334 (1), 19208619 (1), 8876242 (1), 7501022 (1)

    Search CenterWatch for drugs/clinical trials and news about NAPA / SNAA 

    Transcripts
    for NAPA gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NAPA gene: 
    NM_003827.3  

    Unigene Cluster for NAPA:

    N-ethylmaleimide-sensitive factor attachment protein, alpha
    Hs.730799  [show with all ESTs]
    Unigene Representative Sequence: NM_003827
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263354(uc002phd.2 uc002pha.2 uc002phc.2 uc010elf.2 uc002phe.3 uc010elg.2)


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NAPA
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NAPA (see all 9):
    hsa-miR-4324 hsa-miR-1301 hsa-miR-548t hsa-miR-649 hsa-miR-1184 hsa-miR-1207-3p hsa-miR-628-5p hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmid: NAPA 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NAPA (see all 7)
    OriGene shRNA RFP: NAPA
    OriGene siRNA: NAPA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NAPA
    Clone
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    GenScript: all cDNA clones in your preferred vector: NAPA (NM_003827)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NAPA
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPA

    Additional cDNA sequence: 

    AK098401.1 AK292244.1 AK308633.1 AK310114.1 AK310185.1 AY927608.1 AY927609.1 AY927610.1 
    BC001165.1 BC007432.2 BC028234.1 BC091511.1 BT019568.1 NR_038456.1 NR_038457.1 U39412.1 

    24/37 DOTS entries (see all 37):

    DT.219085  DT.100880773  DT.100880761  DT.95235725  DT.95231931  DT.95253523  DT.102834206  DT.100760885 
    DT.121497234  DT.40316388  DT.121497297  DT.92455399  DT.121497264  DT.435399  DT.95173659  DT.95173673 
    DT.100880760  DT.101984713  DT.40266091  DT.95173652  DT.121497214  DT.121497215  DT.92455388  DT.100809518 

    24/725 AceView cDNA sequences (see all 725):

    BG675047 BM674424 BU168063 BQ936966 BQ688226 BQ877679 BM696160 AI608616 
    CB152113 CR600985 BM793615 BE780183 BQ270496 BU782697 BQ948081 CR590241 
    BQ422985 BM667919 BF965926 CR604334 BQ549677 CR596698 CR622644 BM837073 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for NAPA (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
    SP1:                                -                 -           -     -     -           -           -           -                 -     -     -               
    SP2:                                -     -           -           -     -     -           -           -           -                 -     -     -               
    SP3:                                -     -           -           -     -     -           -           -           -     -     -     -     -     -           -   
    SP4:                                -     -           -     -     -     -     -           -           -           -                                             
    SP5:                                -     -           -           -     -     -           -           -                                                         

    ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NAPA

    Expression
    for NAPA gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See NAPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAPA

    SOURCE GeneReport for Unigene cluster: Hs.730799
        SABiosciences Custom PCR Arrays for NAPA
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPA
    In Situ
    Assay Products:     
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    Orthologs
    for NAPA gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NAPA gene from 9/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Napa1 , 5 N-ethylmaleimide sensitive fusion protein attachment more1, 5 90.51(n)1
    98.31(a)1    		   7 (8.74 cM)5
    1081241  NM_025898.31  NP_080174.11 
     160984585 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 90(a)
    89(a)
    		 many → 1
    many → 1
    		 GL343564.1(178497-203956)
    2(193191407-193192297)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.167592 Xenopus laevis transcribed sequence with moderate similarity more 78.74(n)    CA791648.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa26c042 wufa26c04 76.66(n)   327082  AY398385.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Snap1 , 3 ER to Golgi transport soluble NSF attachment
    protein3
    Soluble NSF attachment protein1    		 61(a)3
    66.09(n)1
    61.81(a)1    		   3 77B33
    402331  NM_079456.31  NP_524180.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea D1014.33
    snap-11    		 alpha-SNAP protein3
    Protein SNAP-11    		 51(a)3
    55.02(n)1
    51.71(a)1    		   V(8132963-8135654)3
    1791931  NM_072698.21  NP_505099.21 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes SEC171 Sec17p 46.74(n)
    35.66(a)    		   852230   NP_009503.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ASNAP6
    ALPHA-SNAP16
    		 alpha-soluble NSF attachment protein 1
    		 42(a)
    22(a)
    		 many ↔ many
    many ↔ many
    		 3(20845674-20848534)
    3(20930557-20932869)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 alpha-soluble NSF attachment protein, putative, ex...
    		 40(a)
    		 1 → many
    		 8(11101728-11107281)


    ENSEMBL Gene Tree for NAPA (if available)
    TreeFam Gene Tree for NAPA (if available) 

    Paralogs
    for NAPA gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAPA gene
    NAPB2  
    1 SIMAP similar gene for NAPA using alignment to 10 protein entries:     SNAA_HUMAN (see all proteins):
    NAPB

    NAPA for paralogs           About GeneDecksing



    Genomic Variants
    for NAPA gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/500 NCBI SNPs in NAPA are shown (see all 500)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs735703241,2
    		C,--47990500(+) TTCCTG/ACCAGA 4 -- ds5001 int12Minor allele frequency- A:0.04WA 120
    rs1155980501,2
    		F,--47990637(+) GGAAAT/CCAAGG 4 -- ds5001 int11Minor allele frequency- C:0.04WA 118
    rs1918376921,2
    		--47990657(+) CCCAAA/GAACCC 4 -- ds5001 int10--------
    rs1825878511,2
    		--47990721(+) GGCCCA/GCCGTC 4 -- ds5001 int10--------
    rs730431691,2
    		C,--47990723(+) CCCACC/TGTCCC 4 -- ds5001 int10--------
    rs1144301621,2
    		F,--47990737(+) GTCTCC/GCCCAC 4 -- ds5001 int11Minor allele frequency- G:0.02WA 118
    rs1869103521,2
    		--47990740(+) TCCCCC/TACCTA 4 -- ds5001 int10--------
    rs1929175701,2
    		--47990784(+) GCATGC/TGCCTG 4 -- ds5001 int10--------
    rs1852392031,2
    		--47990789(+) CGCCTC/GACCTC 4 -- ds5001 int10--------
    rs558005891,2
    		C,F,--47990889(+) GAAGAG/CAGACT 4 -- ds5001 int11Minor allele frequency- C:0.12NA 120

    HapMap Linkage Disequilibrium report for NAPA (47990891 - 48018497 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NAPA
         1 CNV: 4083

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NAPA
    DNA2.0 Custom Variant and Variant Library Synthesis for NAPA

    Disorders / Diseases
    for NAPA gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NAPA for disorders           About GeneDecksing

    OMIM gene information: 603215    OMIM disorders: --

    9 diseases for NAPA:    About MalaCards
    periventricular heterotopia    heterotopia    lyme disease    down syndrome
    tetanus    neuroblastoma    pancreatitis    malaria
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NAPA:
    Hydrocephalus

    Export disorders for NAPA gene to outside databases

    Publications
    for NAPA gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAPA gene, integrated from 9 sources (see all 103):
    (articles sorted by number of sources associating them with NAPA)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PubMed id 9269766)1, 2, 3 Lemons P.P.... Whiteheart S.W. (1997)
    2. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2 Hirose H.... Tagaya M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. (PubMed id 9362506)1, 9 Barnard R.J....Burgoyne R.D. (1997)
    5. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PubMed id 15980433)1, 9 Andreeva A.V....Voyno-Yasenetskaya T. (2005)
    6. The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. (PubMed id 7622514)1, 9 Hanson P.I....Jahn R. (1995)
    7. N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PubMed id 9325254)1, 9 Subramaniam V.N....Hong W. (1997)
    8. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PubMed id 15542541)1, 9 Tomes C.N....Mayorga L.S. (2005)
    9. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 9 Nakajima K.... Tagaya M. (2004)
    10. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PubMed id 9507000)1, 9 Tang B.L....Hong W. (1998)

    External Searches for NAPA gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NAPA gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8775 HGNC: 7641 AceView: NAPA Ensembl:ENSG00000105402 euGenes: HUgn8775
    ECgene: NAPA H-InvDB: NAPA

    Other Databases showing NAPA gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NAPA gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAPA Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NAPA gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NAPA gene:
    Search GeneIP for patents involving NAPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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