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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAPA Gene

protein-coding   GIFtS: 61
GCID: GC19M047990

N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 5

Aliases
N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha1 2     Alpha-Soluble NSF Attachment Protein2
SNAPA2 3     SNAP-alpha3
Alpha SNAP1     N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha3
alpha-SNAP2     S5

External Ids:    HGNC: 76411   Entrez Gene: 87752   Ensembl: ENSG000001054027   OMIM: 6032155   UniProtKB: P549203   
ORGUL members:    fRNAdb10:FR099564      
NCBI13:AY927608    
NONCODE14:n336906 n410994 n410995      
RNAdb15:LIT3598    

Export aliases for NAPA gene to outside databases

Previous GC identifers: GC19M048637 GC19M048381 GC19M052666 GC19M052682 GC19M052658 GC19M044419


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NAPA Gene:
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role
in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded
protein plays a role in the completion of membrane fusion by mediating the interaction of
N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE)
complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed
for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for NAPA Gene: 
NAPA (N-ethylmaleimide-sensitive factor attachment protein, alpha) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NAPA include periventricular heterotopia, and lyme disease, and among its related super-pathways are Synaptic Vesicle Pathway and Golgi Associated Vesicle Biogenesis. GO annotations related to this gene include protein binding and syntaxin binding. An important paralog of this gene is NAPB.

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Wiki entry for NAPA Gene

fRNAdb sequence ontology for NAPA:
mature_transcript - A transcript which has undergone the necessary modifications, if any, for its function. In eukaryotes this includes, for example, processing of introns, cleavage, base modification, and modifications to the 5' and/or the 3' ends, other than addition of bases. In bacteria functional mRNAs are usually not modified.

View fRNAdb secondary structures for NAPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAPA gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAPA promoter sequence
   Search SABiosciences Chromatin IP Primers for NAPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

NAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047990:  view genomic region     (about GC identifiers)

Start:
47,990,891 bp from pter      End:
48,018,515 bp from pter
Size:
27,625 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NAPA

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920 (See protein sequence)
Recommended Name: Alpha-soluble NSF attachment protein  
Size: 295 amino acids; 33233 Da
Subunit: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the
internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that
contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By
similarity)
Subcellular location: Membrane; Peripheral membrane protein
Secondary accessions: A8K879 Q96IK3 Q9BVJ3

Explore the universe of human proteins at neXtProt for NAPA: NX_P54920

Explore proteomics data for NAPA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P54920

  • NAPA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NAPA Protein Expression
    REFSEQ proteins: NP_003818.2  
    ENSEMBL proteins: 
     ENSP00000263354   ENSP00000472235   ENSP00000471520   ENSP00000470654   ENSP00000472667  
     ENSP00000471261   ENSP00000470665   ENSP00000470946   ENSP00000471018   ENSP00000470954  
    Reactome Protein details: P54920
    Human Recombinant Protein Products for NAPA: 
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    Novus Biologicals NAPA Proteins
    Novus Biologicals NAPA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NAPA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA--

    NAPA for ontologies           About GeneDecksing



    NAPA Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR000744 NSF_attach
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry P54920

    ProtoNet protein and cluster: P54920

    1 Blocks protein domain: IPB000744 NSF attachment protein signature

    UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
    Similarity: Belongs to the SNAP family


    NAPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNAA_HUMAN, P54920
    Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI15029241
    GO:0019905syntaxin binding IEA--
         
    NAPA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAPA:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Napa):
     behavior/neurological  craniofacial  hearing/vestibular/ear  mortality/aging  nervous system 
     skeleton 

    NAPA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NAPA 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAPA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAPA 

    miRNA
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    hsa-miR-4324 hsa-miR-1301 hsa-miR-548t hsa-miR-649 hsa-miR-1184 hsa-miR-1207-3p hsa-miR-628-5p hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAPA 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NAPA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic vesicle cycle0.50
    Synaptic Vesicle Pathway0.50
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    3Membrane Trafficking
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NAPA
        Synaptic Vesicle Pathway


    4        Reactome Pathways for NAPA
        Membrane Trafficking
    Clathrin derived vesicle budding
    Golgi Associated Vesicle Biogenesis
    trans-Golgi Network Vesicle Budding


    1         Kegg Pathway  (Kegg details for NAPA):
        Synaptic vesicle cycle


    NAPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NAPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/54 Interacting proteins for NAPA (P549201, 2, 3 ENSP000002633544) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STX4Q128461, 2, 3, ENSP000003177144EBI-749652,EBI-744942 MINT-68367 I2D: score=6 STRING: ENSP00000317714
    NSFP464592, 3, ENSP000003812934MINT-8217389 I2D: score=8 STRING: ENSP00000381293
    RTN4Q9NQC32, 3, ENSP000003378384MINT-67570 I2D: score=5 STRING: ENSP00000337838
    STX5Q131902, 3, ENSP000002941794MINT-67752 I2D: score=5 STRING: ENSP00000294179
    SNAP23O001611, 3, ENSP000002496474EBI-749652,EBI-745000 I2D: score=4 STRING: ENSP00000249647
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006891intra-Golgi vesicle-mediated transport TAS8455721
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0007420brain development IEA--
    GO:0010807regulation of synaptic vesicle priming IEA--

    NAPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NAPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NAPA (SNAA)

    7 Novoseek inferred chemical compound relationships for NAPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 66.2 5 11279210 (1), 7835334 (1), 10716927 (1), 10601471 (1) (see all 5)
    mgatp 50 2 9362506 (1)
    atp 36.9 9 9325254 (2), 7957884 (1), 8744944 (1), 8702750 (1) (see all 5)
    catecholamine 10.9 2 7835334 (1), 10662817 (1)
    cysteine 5.87 3 10662817 (1), 11604405 (1)
    lipid 0 7 9230135 (3), 17922004 (2), 10716927 (1)
    calcium 0 6 7835334 (1), 19208619 (1), 8876242 (1), 7501022 (1)

    Search CenterWatch for drugs/clinical trials and news about NAPA / SNAA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for NAPA gene: 
    NM_003827.3  

    Unigene Cluster for NAPA:

    N-ethylmaleimide-sensitive factor attachment protein, alpha
    Hs.730799  [show with all ESTs]
    Unigene Representative Sequence: NM_003827
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000263354(uc002phd.2 uc002pha.2 uc002phc.2 uc010elf.2 uc002phe.3 uc010elg.2)
    ENST00000597778 ENST00000594217 ENST00000597271 ENST00000595227 ENST00000594001
    ENST00000593761 ENST00000593905 ENST00000594155 ENST00000601208 ENST00000598615
    ENST00000602082 ENST00000602174 ENST00000595826 ENST00000597118 ENST00000596892
    ENST00000594288 ENST00000594740
    miRNA
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    hsa-miR-4324 hsa-miR-1301 hsa-miR-548t hsa-miR-649 hsa-miR-1184 hsa-miR-1207-3p hsa-miR-628-5p hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAPA 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NAPA

    Additional mRNA sequence: 

    AK098401.1 AK292244.1 AK308633.1 AK310114.1 AK310185.1 AY927608.1 AY927609.1 AY927610.1 
    BC001165.1 BC007432.2 BC028234.1 BC091511.1 BT019568.1 NR_038456.1 NR_038457.1 U39412.1 

    24/37 DOTS entries (see all 37):

    DT.219085  DT.100880773  DT.100880761  DT.95235725  DT.95231931  DT.95253523  DT.102834206  DT.435399 
    DT.100760885  DT.121497234  DT.40316388  DT.121497297  DT.92455399  DT.121497264  DT.95173659  DT.95173673 
    DT.100880760  DT.101984713  DT.40266091  DT.95173652  DT.121497214  DT.121497215  DT.92455388  DT.95173658 

    24/725 AceView cDNA sequences (see all 725):

    CD108027 BP370365 BM762198 BM559181 BQ422985 BF965926 BM667919 CR604334 
    BQ549677 CR622644 AA321510 CR596698 BM837073 AI819965 BE894926 BE264255 
    BM837607 BQ930054 BI767822 BU163298 AI952100 BP372701 CR617474 CD107311 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for NAPA (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
    SP1:                                -                 -           -     -     -           -           -           -                 -     -     -               
    SP2:                                -     -           -           -     -     -           -           -           -                 -     -     -               
    SP3:                                -     -           -           -     -     -           -           -           -     -     -     -     -     -           -   
    SP4:                                -     -           -     -     -     -     -           -           -           -                                             
    SP5:                                -     -           -           -     -     -           -           -                                                         

    ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NAPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NAPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NAPA Expression
    About this image


    See NAPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NAPA

    SOURCE GeneReport for Unigene cluster: Hs.730799
        SABiosciences Custom PCR Arrays for NAPA
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAPA gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Napa1 , 5 N-ethylmaleimide sensitive fusion protein attachment more1, 5 90.51(n)1
    98.31(a)1
      7 (8.74 cM)5
    1081241  NM_025898.31  NP_080174.11 
     160984585 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    90(a)
    89(a)
    many → 1
    many → 1
    GL343564.1(177726-203956)
    2(193191407-193192297)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167592 Xenopus laevis transcribed sequence with moderate similarity more 78.74(n)    CA791648.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa26c042 wufa26c04 76.66(n)   327082  AY398385.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Snap1 , 3 ER to Golgi transport soluble NSF
    attachment protein3
    Soluble NSF attachment protein1
    61(a)3
    66.09(n)1
    61.81(a)1
      3 77B33
    402331  NM_079456.31  NP_524180.11 
    worm
    (Caenorhabditis elegans)
    Secernentea D1014.33
    snap-11
    alpha-SNAP protein3
    Protein SNAP-11
    51(a)3
    55.02(n)1
    51.71(a)1
      V(8132963-8135654)3
    1791931  NM_072698.21  NP_505099.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC171 Sec17p 46.74(n)
    35.66(a)
      852230   NP_009503.1 


    ENSEMBL Gene Tree for NAPA (if available)
    TreeFam Gene Tree for NAPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NAPA gene
    NAPB2  
    1 SIMAP similar gene for NAPA using alignment to 10 protein entries:     SNAA_HUMAN (see all proteins):
    NAPB

    NAPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/277 SNPs in NAPA are shown (see all 277)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895386921,2
    --48005368(+) TGGCAC/TGTGCC 3 -- int10--------
    rs105692951,2
    C--48005495(+) gtctc-/A/AA/AAA/AA
    AAA
    /AAAAAAAAAA
    aaaaa
    4 -- int1 cds11NA 2
    rs1474614531,2
    C--48005495(+) AAAAA-/AATTTCA 3 -- int10--------
    rs1160492141,2
    F--48005549(+) TTACCG/AGGGGG 3 -- int12Minor allele frequency- A:0.03WA NA 238
    rs1443737821,2
    --48005626(+) CACCTA/GTGTAA 3 -- int10--------
    rs1148472961,2
    C,F--48005716(+) CACAAC/TGTATT 3 -- int11Minor allele frequency- T:0.02WA 118
    rs1478597091,2
    --48005717(+) ACAACA/GTATTT 3 -- int10--------
    rs81064551,2
    C,F,A,H--48005996(+) GCCTGC/TAGGGA 3 -- int117Minor allele frequency- T:0.15NS EA NA WA 2336
    rs1414178091,2
    --48006132(+) CTGAAC/TCTTGG 3 -- int10--------
    rs1453939741,2
    --48006134(+) GAATCA/TTGGTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for NAPA (47990891 - 48018515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NAPA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718664CNV Deletion23290073
    esv2718665CNV Deletion23290073
    esv2131971CNV Deletion18987734
    nsv912202CNV Loss21882294
    nsv138407CNV Loss16902084
    nsv428366CNV Loss18775914
    dgv1107e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603215OMIM information:   
    9 diseases for NAPA:    About MalaCards
    periventricular heterotopia    lyme disease    hydrocephalus    tetanus
    down syndrome    neuroblastoma    endotheliitis    pancreatitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NAPA:
    Hydrocephalus

    NAPA for disorders           About GeneDecksing


    Export disorders for NAPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NAPA gene, integrated from 9 sources (see all 109):
    (articles sorted by number of sources associating them with NAPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PubMed id 9269766)1, 2, 3 Lemons P.P.... Whiteheart S.W. (1997)
    2. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2 Hirose H.... Tagaya M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. (PubMed id 9362506)1, 9 Barnard R.J....Burgoyne R.D. (1997)
    5. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PubMed id 15980433)1, 9 Andreeva A.V....Voyno-Yasenetskaya T. (2005)
    6. The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. (PubMed id 7622514)1, 9 Hanson P.I....Jahn R. (1995)
    7. N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PubMed id 9325254)1, 9 Subramaniam V.N....Hong W. (1997)
    8. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PubMed id 15542541)1, 9 Tomes C.N....Mayorga L.S. (2005)
    9. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 9 Nakajima K.... Tagaya M. (2004)
    10. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PubMed id 9507000)1, 9 Tang B.L....Hong W. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8775 HGNC: 7641 AceView: NAPA Ensembl:ENSG00000105402 euGenes: HUgn8775
    ECgene: NAPA Kegg: 8775 H-InvDB: NAPA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NAPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NAPA gene:
    Search GeneIP for patents involving NAPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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