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NAPA Gene

protein-coding   GIFtS: 58
GCID: GC19M047990

N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Ethylmaleimide-Sensitive Factor Attachment Protein, Alpha1 2     Alpha-Soluble NSF Attachment Protein2
SNAPA2 3     SNAP-alpha3
Alpha SNAP1     N-Ethylmaleimide-Sensitive Factor Attachment Protein Alpha3
alpha-SNAP2     S5

External Ids:    HGNC: 76411   Entrez Gene: 87752   Ensembl: ENSG000001054027   OMIM: 6032155   UniProtKB: P549203   

Export aliases for NAPA gene to outside databases

Previous GC identifers: GC19M048637 GC19M048381 GC19M052666 GC19M052682 GC19M052658 GC19M044419


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NAPA Gene:
This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role
in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. The encoded
protein plays a role in the completion of membrane fusion by mediating the interaction of
N-ethylmaleimide-sensitive factor (NSF) with the vesicle-associated and membrane-associated SNAP receptor (SNARE)
complex, and stimulating the ATPase activity of NSF. Alternatively spliced transcript variants have been observed
for this gene. (provided by RefSeq, Jun 2011)

GeneCards Summary for NAPA Gene:
NAPA (N-ethylmaleimide-sensitive factor attachment protein, alpha) is a protein-coding gene. Diseases associated with NAPA include periventricular heterotopia, and lyme disease. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is NAPB.

UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Gene Wiki entry for NAPA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NAPA gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNAPA promoter sequence
   Search Chromatin IP Primers for NAPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

NAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047990:  view genomic region     (about GC identifiers)

Start:
47,990,891 bp from pter      End:
48,018,515 bp from pter
Size:
27,625 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for NAPA

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920 (See protein sequence)
Recommended Name: Alpha-soluble NSF attachment protein  
Size: 295 amino acids; 33233 Da
Subunit: Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the
internalization of GRIA2. Found in a complex with VAMP8 (By similarity). Component of a SNARE-like complex that
contains at least ZW10, USE1L, RINT1, STX18 and NAPA/SNAP-alpha. Interacts with VTI1A. Interacts with STX12 (By
similarity)
Secondary accessions: A8K879 Q96IK3 Q9BVJ3

Explore the universe of human proteins at neXtProt for NAPA: NX_P54920

Explore proteomics data for NAPA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys22, Lys153, Lys227
  • Modification sites at PhosphoSitePlus

  • See NAPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003818.2  
    ENSEMBL proteins: 
     ENSP00000263354   ENSP00000472235   ENSP00000471520   ENSP00000470654   ENSP00000472667  
     ENSP00000471261   ENSP00000470665   ENSP00000470946   ENSP00000471018   ENSP00000470954  
    Reactome Protein details: P54920

    NAPA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NAPA
    OriGene Protein Over-expression Lysate for NAPA
    OriGene MassSpec for NAPA
    OriGene Custom Protein Services for NAPA
    GenScript Custom Purified and Recombinant Proteins Services for NAPA
    Novus Biologicals NAPA Proteins
    Novus Biologicals NAPA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NAPA
    Browse Proteins at Cloud-Clone Corp.

    NAPA Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NAPA Antibodies
    Abcam antibodies for NAPA (P54920, Q9H115)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NAPA
    LSBio Antibodies in human, mouse, rat for NAPA

    NAPA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NAPA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NAPA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000744 NSF_attach
     IPR011990 TPR-like_helical

    Graphical View of Domain Structure for InterPro Entry P54920

    ProtoNet protein and cluster: P54920

    1 Blocks protein domain: IPB000744 NSF attachment protein signature

    UniProtKB/Swiss-Prot: SNAA_HUMAN, P54920
    Similarity: Belongs to the SNAP family


    NAPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SNAA_HUMAN, P54920
    Function: Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding ----
    GO:0005515protein binding IPI15029241
    GO:0019905syntaxin binding IEA--
         
    NAPA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NAPA:
     Decreased Hepatitis C virus re  Decreased viability of wild-ty 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Napa):
     behavior/neurological  craniofacial  hearing/vestibular/ear  mortality/aging  nervous system 
     skeleton 

    NAPA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NAPA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NAPA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NAPA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NAPA

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NAPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAPA (see all 9):
    hsa-miR-4324 hsa-miR-1301 hsa-miR-548t hsa-miR-649 hsa-miR-1184 hsa-miR-1207-3p hsa-miR-628-5p hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAPA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NAPA
    Predesigned siRNA for gene silencing in human, mouse, rat NAPA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NAPA

    Clone
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    OriGene clones in human, mouse for NAPA (see all 6)
    OriGene ORF clones in mouse, rat for NAPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAPA (NM_003827)
    Sino Biological Human cDNA Clone for NAPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPA

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NAPA
    Browse ESI BIO Cell Lines and PureStem Progenitors for NAPA 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SNAA_HUMAN, P54920: Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    golgi apparatus2
    nucleus2
    plasma membrane2
    vacuole2
    endoplasmic reticulum1
    endosome1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0070044synaptobrevin 2-SNAP-25-syntaxin-1a complex IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    NAPA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NAPA About    
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NAPA
        Synaptic Vesicle Pathway


    1 Reactome Pathway for NAPA
        Golgi Associated Vesicle Biogenesis


    1 Kegg Pathway  (Kegg details for NAPA):
        Synaptic vesicle cycle


    NAPA for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAPA
    Interactions:

        GeneGlobe Interaction Network for NAPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NAPA (P549201, 2, 3 ENSP000002633544) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NSFP464591, 2, 3, ENSP000003812934EBI-749652,EBI-712251 MINT-8217389 I2D: score=8 STRING: ENSP00000381293
    STX4Q128461, 2, 3, ENSP000003177144EBI-749652,EBI-744942 MINT-68367 I2D: score=6 STRING: ENSP00000317714
    RTN4Q9NQC32, 3, ENSP000003378384MINT-67570 I2D: score=5 STRING: ENSP00000337838
    STX5Q131902, 3, ENSP000002941794MINT-67752 I2D: score=5 STRING: ENSP00000294179
    SNAP23O001611, 3, ENSP000002496474EBI-749652,EBI-745000 I2D: score=4 STRING: ENSP00000249647
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport IEA--
    GO:0006891intra-Golgi vesicle-mediated transport TAS8455721
    GO:0006892post-Golgi vesicle-mediated transport TAS--
    GO:0007420brain development IEA--
    GO:0010807regulation of synaptic vesicle priming IEA--

    NAPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NAPA (SNAA)

    7 Novoseek inferred chemical compound relationships for NAPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    n-ethylmaleimide 66.2 5 11279210 (1), 7835334 (1), 10716927 (1), 10601471 (1) (see all 5)
    mgatp 50 2 9362506 (1)
    atp 36.9 9 9325254 (2), 7957884 (1), 8744944 (1), 8702750 (1) (see all 5)
    catecholamine 10.9 2 7835334 (1), 10662817 (1)
    cysteine 5.87 3 10662817 (1), 11604405 (1)
    lipid 0 7 9230135 (3), 17922004 (2), 10716927 (1)
    calcium 0 6 7835334 (1), 19208619 (1), 8876242 (1), 7501022 (1)



    NAPA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NAPA gene: 
    NM_003827.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000263354(uc002phd.2 uc002pha.2 uc002phc.2 uc010elf.2 uc002phe.3 uc010elg.2)
    ENST00000597778 ENST00000594217 ENST00000597271 ENST00000595227 ENST00000594001
    ENST00000593761 ENST00000593905 ENST00000594155 ENST00000601208 ENST00000598615
    ENST00000602082 ENST00000602174 ENST00000595826 ENST00000597118 ENST00000596892
    ENST00000594288 ENST00000594740
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NAPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NAPA (see all 9):
    hsa-miR-4324 hsa-miR-1301 hsa-miR-548t hsa-miR-649 hsa-miR-1184 hsa-miR-1207-3p hsa-miR-628-5p hsa-miR-490-3p
    SwitchGear 3'UTR luciferase reporter plasmidNAPA 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NAPA
    Predesigned siRNA for gene silencing in human, mouse, rat NAPA
    Clone
    Products:
         
    OriGene clones in human, mouse for NAPA (see all 6)
    OriGene ORF clones in mouse, rat for NAPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NAPA (NM_003827)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NAPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NAPA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NAPA
    OriGene qSTAR qPCR primer pairs in human, mouse for NAPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAPA
      QuantiTect SYBR Green Assays in human, mouse, rat NAPA
      QuantiFast Probe-based Assays in human, mouse, rat NAPA

    Selected AceView cDNA sequences (see all 725):

    AI659911 BU634122 BQ128368 BQ670041 AI133500 AI097319 BX378243 AI751472 
    BM310269 CR624444 BU579824 BX399331 CD107311 BU070452 BE256425 BM762198 
    BP369198 BM511611 AI952100 BM823025 BQ426000 AW591617 BM453185 AU076757 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NAPA (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12 ^ 13a ·
    SP1:                                -                 -           -     -     -           -           -           -                 -     -     -               
    SP2:                                -     -           -           -     -     -           -           -           -                 -     -     -               
    SP3:                                -     -           -           -     -     -           -           -           -     -     -     -     -     -           -   
    SP4:                                -     -           -     -     -     -     -           -           -           -                                             
    SP5:                                -     -           -           -     -     -           -           -                                                         

    ExUns: 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          


    ECgene alternative splicing isoforms for NAPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NAPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NAPA Expression
    About this image


    NAPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    NAPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NAPA Protein Expression
        Custom PCR Arrays for NAPA
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NAPA
    OriGene qSTAR qPCR primer pairs in human, mouse for NAPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NAPA
    QuantiTect SYBR Green Assays in human, mouse, rat NAPA
    QuantiFast Probe-based Assays in human, mouse, rat NAPA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NAPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NAPA gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Napa1 , 5 N-ethylmaleimide sensitive fusion protein attachment more1, 5 90.51(n)1
    98.31(a)1
      7 (8.74 cM)5
    1081241  NM_025898.31  NP_080174.11 
     160984585 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    90(a)
    89(a)
    many → 1
    many → 1
    GL343564.1(177726-203956)
    2(193191407-193192297)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.167592 Xenopus laevis transcribed sequence with moderate similarity more 78.74(n)    CA791648.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa26c042 wufa26c04 76.66(n)   327082  AY398385.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Snap1 , 3 ER to Golgi transport soluble NSF
    attachment protein3
    Soluble NSF attachment protein1
    61(a)3
    65.58(n)1
    62.32(a)1
      3 77B33
    402331  NM_079456.41  NP_524180.11 
    worm
    (Caenorhabditis elegans)
    Secernentea D1014.33
    snap-11
    alpha-SNAP protein3
    snap-11
    51(a)3
    55.35(n)1
    52.35(a)1
      V(8132963-8135654)3
    1791931  NM_072698.31  NP_505099.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SEC171 SEC17 47.09(n)
    36.06(a)
      852230   NP_009503.1 


    ENSEMBL Gene Tree for NAPA (if available)
    TreeFam Gene Tree for NAPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NAPA gene
    NAPB2  
    1 SIMAP similar gene for NAPA using alignment to 10 protein entries:     SNAA_HUMAN (see all proteins):
    NAPB

    NAPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NAPA (see all 277)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1895386921,2
    --48005368(+) TGGCAC/TGTGCC 3 -- int10--------
    rs105692951,2
    C--48005495(+) gtctc-/A/AA/AAA/AA
    AAA
    /AAAAAAAAAA
    aaaaa
    4 -- int1 cds11NA 2
    rs1474614531,2
    C--48005495(+) AAAAA-/AATTTCA 3 -- int10--------
    rs1160492141,2
    F--48005549(+) TTACCG/AGGGGG 3 -- int12Minor allele frequency- A:0.03WA NA 238
    rs1443737821,2
    --48005626(+) CACCTA/GTGTAA 3 -- int10--------
    rs1148472961,2
    C,F--48005716(+) CACAAC/TGTATT 3 -- int11Minor allele frequency- T:0.02WA 118
    rs1478597091,2
    --48005717(+) ACAACA/GTATTT 3 -- int10--------
    rs81064551,2
    C,F,A,H--48005996(+) GCCTGC/TAGGGA 3 -- int117Minor allele frequency- T:0.15NS EA NA WA 2336
    rs1414178091,2
    --48006132(+) CTGAAC/TCTTGG 3 -- int10--------
    rs1453939741,2
    --48006134(+) GAATCA/TTGGTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for NAPA (47990891 - 48018515 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NAPA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718664CNV Deletion23290073
    esv2718665CNV Deletion23290073
    esv2131971CNV Deletion18987734
    nsv912202CNV Loss21882294
    nsv138407CNV Loss16902084
    nsv428366CNV Loss18775914
    dgv1107e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NAPA
    DNA2.0 Custom Variant and Variant Library Synthesis for NAPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603215    OMIM disorders: --

    10 diseases for NAPA:    
    About MalaCards
    periventricular heterotopia    lyme disease    hydrocephalus    tetanus
    down syndrome    neuroblastoma    endotheliitis    malaria
    pancreatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NAPA:
    Hydrocephalus

    NAPA for disorders           About GeneDecksing


    Export disorders for NAPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NAPA gene, integrated from 10 sources (see all 113):
    (articles sorted by number of sources associating them with NAPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. (PubMed id 9269766)1, 2, 3 Lemons P.P.... Whiteheart S.W. (Blood 1997)
    2. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. (PubMed id 15029241)1, 2 Hirose H.... Tagaya M. (EMBO J. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Stimulation of NSF ATPase activity by alpha-SNAP is required for SNARE complex disassembly and exocytosis. (PubMed id 9362506)1, 9 Barnard R.J....Burgoyne R.D. (J. Cell Biol. 1997)
    5. G alpha12 interaction with alphaSNAP induces VE-cadherin localization at endothelial junctions and regulates barrier function. (PubMed id 15980433)1, 9 Andreeva A.V....Voyno-Yasenetskaya T. (J. Biol. Chem. 2005)
    6. The N-ethylmaleimide-sensitive fusion protein and alpha-SNAP induce a conformational change in syntaxin. (PubMed id 7622514)1, 9 Hanson P.I....Jahn R. (J. Biol. Chem. 1995)
    7. N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex. (PubMed id 9325254)1, 9 Subramaniam V.N....Hong W. (J. Biol. Chem. 1997)
    8. alpha-SNAP and NSF are required in a priming step during the human sperm acrosome reaction. (PubMed id 15542541)1, 9 Tomes C.N....Mayorga L.S. (Mol. Hum. Reprod. 2005)
    9. Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. (PubMed id 15272311)1, 9 Nakajima K.... Tagaya M. (EMBO J. 2004)
    10. Syntaxin 12, a member of the syntaxin family localized to the endosome. (PubMed id 9507000)1, 9 Tang B.L....Hong W. (J. Biol. Chem. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8775 HGNC: 7641 AceView: NAPA Ensembl:ENSG00000105402 euGenes: HUgn8775
    ECgene: NAPA Kegg: 8775 H-InvDB: NAPA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NAPA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NAPA gene:
    Search GeneIP for patents involving NAPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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