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NAP1L6 Gene

protein-coding   GIFtS: 30
GCID: GC0XM072345

Nucleosome Assembly Protein 1-Like 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleosome Assembly Protein 1-Like 61 2

External Ids:    HGNC: 317061   Entrez Gene: 6459962   Ensembl: ENSG000002041187   UniProtKB: A6NFF23   

Export aliases for NAP1L6 gene to outside databases

Previous GC identifers: GC0XM072262 GC0XM065979


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NAP1L6 Gene:
NAP1L6 (nucleosome assembly protein 1-like 6) is a protein-coding gene. An important paralog of this gene is NAP1L3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011651.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NAP1L6 gene promoter:
         HOXA9   HOXA9B   HNF-1A   Evi-1   Meis-1b   HNF-1   NF-kappaB1   Meis-1   En-1   
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NAP1L6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13.2

NAP1L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAP1L6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM072345:  view genomic region     (about GC identifiers)

Start:
72,345,876 bp from pter      End:
72,347,919 bp from pter
Size:
2,044 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NP1L6_HUMAN, A6NFF2 (See protein sequence)
Recommended Name: Putative nucleosome assembly protein 1-like 6  
Size: 107 amino acids; 12045 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NAP1L6: NX_A6NFF2

Explore proteomics data for NAP1L6 at MOPED


See NAP1L6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


ENSEMBL proteins: 
 ENSP00000362617  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry A6NFF2

ProtoNet protein and cluster: A6NFF2

UniProtKB/Swiss-Prot: NP1L6_HUMAN, A6NFF2
Similarity: Belongs to the nucleosome assembly protein (NAP) family


Find genes that share domains with NAP1L6           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for NAP1L6:
 Synthetic lethal with Ras 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for NAP1L6

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with NAP1L6           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NAP1L6
Interactions:

    Search GeneGlobe Interaction Network for NAP1L6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NAP1L6 (ENSP000003626174) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
InteractantInteraction Details
GeneCardExternal ID(s)
IPO9ENSP000003547424STRING: ENSP00000354742
SDAD1ENSP000003485964STRING: ENSP00000348596
H2AFVENSP000003084054STRING: ENSP00000308405
H2AFZENSP000002964174STRING: ENSP00000296417
RPS6ENSP000003697574STRING: ENSP00000369757
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IEA--

Find genes that share ontologies with NAP1L6           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Tocris compounds for NAP1L6 (NP1L6)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for NAP1L6:

Nucleosome assembly protein 1-like 6
Hs.617486  [show with all ESTs]
Unigene Representative Sequence: AK090915
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000373518(uc004ebh.1)
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Additional mRNA sequence: 

AK090915.1 NR_027291.1 

1 DOTS entry:

DT.99933128 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NAP1L6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTTTTGTCA
NAP1L6 Expression
About this image

NAP1L6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NAP1L6 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.617486
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L6 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
11(a)
1 → many
1(37871087-37885437)
lizard
(Anolis carolinensis)
Reptilia --
--
11(a)
1 → many
5(40559945-40619366)
zebrafish
(Danio rerio)
Actinopterygii nap1l16
nucleosome assembly protein 1, like 1
11(a)
1 → many
4(2216012-2241310) ENSDARG00000002400
fruit fly
(Drosophila melanogaster)
Insecta CG50176
Nap16
(see all 3)
Nucleosome assembly protein 1
(see all 3)
6(a)
6(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
3R(23738169-23739507)
2R(19792698-19794837)
worm
(Caenorhabditis elegans)
Secernentea nap-16
Protein NAP-1 (nap-1) mRNA, complete cds
9(a)
1 → many
IV(8377705-8379319) WBGene00017075
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP16
Protein that interacts with mitotic cyclin Clb2p; ...
5(a)
1 → many
XI(525387-526640) YKR048C
        Species with no ortholog for NAP1L6

ENSEMBL Gene Tree for NAP1L6 (if available)
TreeFam Gene Tree for NAP1L6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NAP1L6 gene
NAP1L32  NAP1L22  NAP1L42  NAP1L12  
4 SIMAP similar genes for NAP1L6 using alignment to 1 protein entry:     NP1L6_HUMAN:
NAP1L2    NAP1L1    NAP1L4    DKFZp434K0835

Find genes that share paralogs with NAP1L6           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for NAP1L6 (see all 54)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1911576361,2
--72353623(+) CCCAGC/TGAAAT 1 -- ds50010--------
rs1834759401,2
--72353659(+) CAGAAA/GGAACA 1 -- ds50010--------
rs1877626271,2
--72353790(+) GCATAC/TGTTAA 1 -- ds50010--------
rs732203761,2
C--72353980(+) TTATTC/TTTATA 1 -- ds50010--------
rs104821071,2
C,F,A,H--72353991(+) CTAGCA/GGCTTC 1 -- ds500124Minor allele frequency- G:0.69NS EA NA 2619
rs78886711,2
C,F,H--72354246(+) CATACA/GTTGAG 1 -- nc-transcript-variantese312Minor allele frequency- G:0.50NS EA NA WA 639
rs732203771,2
C--72354299(+) GGAGTC/GCTAGA 1 -- nc-transcript-variant0--------
rs1842508471,2
--72354311(+) GAAATA/GCATTG 1 -- nc-transcript-variant0--------
rs1881523851,2
--72354314(+) ATGCAC/TTGTTA 1 -- nc-transcript-variant0--------
rs78889561,2
C,F,H--72354482(+) CCTGGG/CAGTTT 1 -- nc-transcript-variantese36Minor allele frequency- C:0.42NS EA WA NA 405

HapMap Linkage Disequilibrium report for NAP1L6 (72345876 - 72347919 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NAP1L6: --
Locus Specific Mutation Databases (LSDB): NAP1L6

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NAP1L6 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NAP1L6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 645996 HGNC: 31706 Ensembl:ENSG00000204118 euGenes: HUgn645996 ECgene: NAP1L6
H-InvDB: NAP1L6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for NAP1L6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NAP1L6 gene:
Search GeneIP for patents involving NAP1L6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 antibodies-online kits for NAP1L6 (2 products)
  Search antibodies-online for peptides for NAP1L6
 antibodies-online proteins for NAP1L6
       
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