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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NAP1L6 Gene

protein-coding   GIFtS: 30
GCID: GC0XM072345

Nucleosome Assembly Protein 1-Like 6

  Search for NAP1L6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nucleosome Assembly Protein 1-Like 61 2

External Ids:    HGNC: 317061   Entrez Gene: 6459962   Ensembl: ENSG000002041187   UniProtKB: A6NFF23   
ORGUL members:         
NONCODE14:n385781      

Export aliases for NAP1L6 gene to outside databases

Previous GC identifers: GC0XM072262 GC0XM065979


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NAP1L6 Gene: 
NAP1L6 (nucleosome assembly protein 1-like 6) is a protein-coding gene, and is affiliated with the lncRNA class. An important paralog of this gene is NAP1L3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NAP1L6 gene promoter:
         HOXA9   HOXA9B   HNF-1A   Evi-1   Meis-1b   HNF-1   NF-kappaB1   Meis-1   En-1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NAP1L6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13.2

NAP1L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NAP1L6 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM072345:  view genomic region     (about GC identifiers)

Start:
72,345,876 bp from pter      End:
72,347,919 bp from pter
Size:
2,044 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NP1L6_HUMAN, A6NFF2 (See protein sequence)
Recommended Name: Putative nucleosome assembly protein 1-like 6  
Size: 107 amino acids; 12045 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for NAP1L6: NX_A6NFF2

Explore proteomics data for NAP1L6 at MOPED 

NAP1L6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

NAP1L6 Protein Expression

ENSEMBL proteins: 
 ENSP00000362617  

Human Recombinant Protein Products for NAP1L6: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

NAP1L6 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR002164 NAP_family

Graphical View of Domain Structure for InterPro Entry A6NFF2

ProtoNet protein and cluster: A6NFF2

UniProtKB/Swiss-Prot: NP1L6_HUMAN, A6NFF2
Similarity: Belongs to the nucleosome assembly protein (NAP) family


NAP1L6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for NAP1L6:
 Synthetic lethal with Ras 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NAP1L6

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006334nucleosome assembly IEA--

NAP1L6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for NAP1L6 (NP1L6)

Search CenterWatch for drugs/clinical trials and news about NAP1L6 / NP1L6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

Unigene Cluster for NAP1L6:

Nucleosome assembly protein 1-like 6
Hs.617486  [show with all ESTs]
Unigene Representative Sequence: AK090915
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000373518(uc004ebh.1)
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Additional mRNA sequence: 

AK090915.1 NR_027291.1 

1 DOTS entry:

DT.99933128 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NAP1L6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTTTTGTCA
NAP1L6 Expression
About this image


See NAP1L6 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.617486
    SABiosciences Custom PCR Arrays for NAP1L6
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for NAP1L6 gene from 4/6 species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
--
9(a)
9(a)
possible ortholog
possible ortholog
X(79858700-79859594)
X(79603965-79605517)
fruit fly
(Drosophila melanogaster)
Insecta Nap16
CG37086
(see all 3)
--
7(a)
6(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
2R(19792698-19794837)
X(822831-824131)
worm
(Caenorhabditis elegans)
Secernentea nap-16
Protein NAP-1
8(a)
1 → many
IV(8377705-8379321)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAP16
Protein that interacts with mitotic cyclin Clb2p; ...
5(a)
1 → many
XI(525387-526640)


ENSEMBL Gene Tree for NAP1L6 (if available)
TreeFam Gene Tree for NAP1L6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for NAP1L6 gene
NAP1L32  NAP1L22  NAP1L42  NAP1L12  
5 SIMAP similar genes for NAP1L6 using alignment to 1 protein entry:     NP1L6_HUMAN:
NAP1L2    NAP1L1    NAP1L4b    NAP1L4    DKFZp434K0835

NAP1L6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/54 SNPs in NAP1L6 are shown (see all 54)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1911576361,2
--72353623(+) CCCAGC/TGAAAT 1 -- ds50010--------
rs1834759401,2
--72353659(+) CAGAAA/GGAACA 1 -- ds50010--------
rs1877626271,2
--72353790(+) GCATAC/TGTTAA 1 -- ds50010--------
rs732203761,2
C--72353980(+) TTATTC/TTTATA 1 -- ds50010--------
rs104821071,2
C,F,A,H--72353991(+) CTAGCA/GGCTTC 1 -- ds500124Minor allele frequency- G:0.69NS EA NA 2619
rs78886711,2
C,F,H--72354246(+) CATACA/GTTGAG 1 -- nc-transcript-variantese312Minor allele frequency- G:0.50NS EA NA WA 639
rs732203771,2
C--72354299(+) GGAGTC/GCTAGA 1 -- nc-transcript-variant0--------
rs1842508471,2
--72354311(+) GAAATA/GCATTG 1 -- nc-transcript-variant0--------
rs1881523851,2
--72354314(+) ATGCAC/TTGTTA 1 -- nc-transcript-variant0--------
rs78889561,2
C,F,H--72354482(+) CCTGGG/CAGTTT 1 -- nc-transcript-variantese36Minor allele frequency- C:0.42NS EA WA NA 405

HapMap Linkage Disequilibrium report for NAP1L6 (72345876 - 72347919 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for NAP1L6: --

Locus Specific Mutation Databases (LSDB): NAP1L6
SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for NAP1L6 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NAP1L6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 645996 HGNC: 31706 Ensembl:ENSG00000204118 euGenes: HUgn645996 ECgene: NAP1L6
H-InvDB: NAP1L6

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for NAP1L6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for NAP1L6 gene:
Search GeneIP for patents involving NAP1L6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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